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https://www.readbyqxmd.com/read/29909599/survival-of-aggressive-variants-of-papillary-thyroid-carcinoma-in-patients-under-55-years-old-a-seer-population-based-retrospective-analysis
#1
Jianhua Feng, Fei Shen, Wensong Cai, Xiaoxiong Gan, Xingyan Deng, Bo Xu
BACKGROUND: Patients younger than 55 years of age with papillary thyroid carcinoma (PTC) have excellent survival. Diffuse sclerosing variant (DSV) and tall cell variant (TCV) of PTC are associated with aggressiveness; the survival of patients <55 years of age with these variants is still unclear. We aim to investigate the clinicopathological features and survival of these variants in the age group <55 years. METHODS: All adult patients (<55 years old) with DSV, TCV and conventional PTC (CPTC) came from the Surveillance, Epidemiology, and End Results program (1988-2013)...
June 16, 2018: Endocrine
https://www.readbyqxmd.com/read/29909564/organized-screening-detects-breast-cancer-at-earlier-stage-regardless-of-molecular-phenotype
#2
Claire M B Holloway, Li Jiang, Marlo Whitehead, Jennifer M Racz, Patti A Groome
PURPOSE: Mortality reduction attributable to organized breast screening is modest. Screening may be less effective at detecting more aggressive cancers at an earlier stage. This study was conducted to determine the relative efficacy of screening mammography to detect cancers at an earlier stage by molecular phenotype. METHODS: We identified 2882 women with primary invasive breast cancer diagnosed between January 1, 2008 and December 31, 2012 and who had a mammogram through the Ontario Breast Screening Program in the 28 months before diagnosis...
June 16, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29909563/community-pharmacists-perspectives-on-implementation-of-medicines-use-review-in-slovenia
#3
Urska Nabergoj Makovec, Mitja Kos, Nina Pisk
Background In December 2014 Slovene Chamber of Pharmacies defined procedures for Medicines Use Review (MUR) in Slovenia, together with an educational program and certification to ensure pharmacists' competency to perform MUR. The first 15 pharmacists were certified in June 2015 and implemented the service in their practices. Objective This study aimed to understand the implementation of MUR from the perspectives of the first community pharmacists providing the service in practice. Methods A focus group with first MUR providers took place in February 2016, 6 months after the first pharmacists were certified to provide MUR service...
June 16, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29909497/a-retrospective-chart-review-of-children-with-asd-s-individual-education-plans-compared-to-subsequent-independent-psychological-evaluations
#4
Nicholas W Gelbar, Mary Beth Bruder, Emily DeBiase, John D Molteni
The heterogeneity of Autism Spectrum Disorder (ASD) makes it difficult for school-based professionals to develop effective Individual Education Plans (IEP) for this group. Limited research exists on the quality of IEP programs for individuals with ASD. This article summarizes the results of a retrospective chart review from an outpatient diagnostic center. Researchers collected data from IEPs and subsequent psychological evaluations of 75 individuals diagnosed with ASD. The implications of these results for future research and practice are discussed...
June 16, 2018: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29909429/task-set-control-chunking-and-hierarchical-timing-in-rhythm-production
#5
Lars D Hestermann, Johan Wagemans, Ralf T Krampe
We investigated task-set control processes and chunking in 16 novices and 16 amateur musicians, who produced unimanual rhythms in three experimental conditions: low-level timing tasks required isochronous tapping at constant target durations; sequencing tasks consisted of individual rhythmic patterns comprising multiple target durations; the task-set control condition required alternations between two rhythmic patterns. According to our hierarchical timing control model conditions differed in their task-set control demands necessary to provide rhythm programs for the sequencing of individual intervals...
June 16, 2018: Psychological Research
https://www.readbyqxmd.com/read/29909355/understanding-direct-neuronal-reprogramming-from-pioneer-factors-to-3d-chromatin
#6
REVIEW
Jovica Ninkovic, Magdalena Götz
Cell replacement therapies aim at reestablishment of neuronal circuits after brain injury, stroke or neurodegeneration. Recently, direct reprogramming of resident glial cells into the affected neuronal subtypes has become a feasible and promising option for central nervous system regeneration. Direct reprogramming relies on the implementation of a new transcriptional program defining the desired neuronal identity in fully differentiated glial cells implying the more or less complete down-regulation of the program for the former identity of the glial cell...
June 14, 2018: Current Opinion in Genetics & Development
https://www.readbyqxmd.com/read/29909237/glycosylation-as-new-pharmacological-strategies-for-diseases-associated-with-excessive-angiogenesis
#7
REVIEW
Simon Bousseau, Luisa Vergori, Raffaella Soleti, Guy Lenaers, M Carmen Martinez, Ramaroson Andriantsitohaina
Angiogenesis is a complex process describing the growth of new blood vessels from existing vasculature, and is triggered by local pro-angiogenic factors, such as vascular endothelial growth factor (VEGF), which increase the metabolism of endothelial cells (ECs). Angiogenesis takes part in various physiological conditions such as embryogenesis, placental growth, and in pathological conditions such as tumor growth, diabetic retinopathy, rheumatoid arthritis (RA) and ischemic diseases. Current therapies against excessive angiogenesis target vascular growth signaling...
June 14, 2018: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29909230/postural-stability-and-trunk-muscle-responses-to-the-static-and-perturbed-balance-tasks-in-individuals-with-and-without-symptomatic-degenerative-lumbar-disease
#8
Yun-Chung Lin, Chi-Chien Niu, Mohammad Nikkhoo, Meng-Ling Lu, Wen-Chien Chen, Chen-Ju Fu, Chih-Hsiu Cheng
BACKGROUND: Degenerative lumbar diseases (DLDs) are characterized by motor functional deficits and postural instability. In this study, we investigated the differences in the trunk muscle responses to postural control between the presurgical DLD patients and healthy individuals while performing the static and perturbed balance tasks. METHODS: Thirty-five DLD patients (aged 61.1 ± 8.0 years) and thirty-five asymptomatic controls (aged 62.9 ± 3.7 years) participated in this study...
June 11, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29909200/epigenetic-control-of-variation-and-stochasticity-in-metabolic-disease
#9
REVIEW
Ilaria Panzeri, John Andrew Pospisilik
BACKGROUND: The alarming rise of obesity and its associated comorbidities represents a medical burden and a major global health and economic issue. Understanding etiological mechanisms underpinning susceptibility and therapeutic response is of primary importance. Obesity, diabetes, and metabolic diseases are complex trait disorders with only partial genetic heritability, indicating important roles for environmental programing and epigenetic effects. SCOPE OF THE REVIEW: We will highlight some of the reasons for the scarce predictability of metabolic diseases...
May 18, 2018: Molecular Metabolism
https://www.readbyqxmd.com/read/29909164/-is-it-possible-to-practice-sports-with-an-implantable-cardioverter-defibrillator
#10
Charles Guenancia, Rodrigue Garcia
Why? The potential risks of sport for an ICD recipient include appropriate and inappropriate shocks, device damage and worsening of the underlying cardiopathy. These risks should be compared to the physical and psychological benefits of exercise. Where? Due to different medico-legal contexts and considering the results of recent studies, the new US guidelines are more permissive than the European guidelines regarding sport practice in ICD recipients. Who? The underlying context (structural or electrical cardiopathy, psychological impact) should be assessed before any decision is taken...
June 13, 2018: La Presse Médicale
https://www.readbyqxmd.com/read/29909049/high-speed-resistance-training-in-elderly-women-effects-of-cluster-training-sets-on-functional-performance-and-quality-of-life
#11
Rodrigo Ramirez-Campillo, Cristian Alvarez, Antonio Garcìa-Hermoso, Carlos Celis-Morales, Robinson Ramirez-Velez, Paulo Gentil, Mikel Izquierdo
OBJECTIVE: To compare the effects of 12 weeks of high-speed resistance training on functional performance and quality of life in elderly women when using either a traditional-set (TS) or a cluster-set (CS) configuration for inter-set rest. METHODS: Three groups of subjects were formed by block-design randomization as follows: (i) control group (CG, n = 17; age, 66.5 ± 5.4 years); (ii) 12-week high-speed resistance training group under a CS configuration (CSG, n = 15; age, 67...
June 14, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29909022/a-review-on-healthy-ageing-interventions-addressing-physical-mental-and-social-health-of-independent-community-dwelling-older-adults
#12
Betsy Seah, Yanika Kowitlawakul, Ying Jiang, Emily Ang, Srinivasan Chokkanathan, Wenru Wang
Healthy ageing is a multi-dimensional concept which appertains to all older adults. This study reviewed the intervention characteristics, intervention content and effectiveness of multi-dimensional healthy ageing interventions (MHAIs) addressing physical, mental and social health among independent community-dwelling older adults. A search was conducted in PubMed, CINAHL, Embase, Scopus, and PsycINFO for studies published from Jan 2007 to October 2016. 18 publications were included, accounting for 15 studies...
June 13, 2018: Geriatric Nursing
https://www.readbyqxmd.com/read/29909013/impact-and-prevalence-of-physical-and-verbal-violence-toward-healthcare-workers
#13
Lisa J Rosenthal, Ashley Byerly, Adrienne D Taylor, Zoran Martinovich
BACKGROUND: Threatening and assaultive behaviors against healthcare workers is a growing national concern.1,2,3 To assess the incidence and impact of aggression against healthcare workers, a safety and quality improvement project was initiated in an academic, tertiary care, and urban hospital. METHODS: Through the Northwestern Academy of Quality and Safety Initiatives program, an invitation to complete an online survey was sent to healthcare workers. The survey inquired about prevalence, location, and type of experience of physical or verbal abuse by patients or families...
May 9, 2018: Psychosomatics
https://www.readbyqxmd.com/read/29908940/a-nomogram-integrating-hepatic-reserve-and-tumor-characteristics-for-hepatocellular-carcinoma-following-curative-liver-resection
#14
Bin-Bin Cai, Ke-Qing Shi, Peng Li, Bi-Cheng Chen, Liang Shi, Philip J Johnson, Paul Lai, Hidenori Toyoda, Meng-Tao Zhou
BACKGROUND: Because of the mutual influence of liver dysfunction and malignancy, overall survival (OS) is a composite clinical endpoint in hepatocellular carcinoma (HCC). We developed a nomogram integrating albumin-bilirubin (ALBI) grade, a new index of hepatic reserve, and tumor characteristics of HCC for predicting OS following curative liver resection. METHODS: The nomogram was built to estimate the probabilities of 1, 3, and 5-y OS based on training cohort of 709 HCC, which was validated in an international independent dataset...
June 14, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29908932/comparison-of-open-and-closed-hand-fractures-and-the-effect-of-urgent-operative-intervention
#15
Shobhit V Minhas, Louis W Catalano
PURPOSE: To establish and compare the incidence of 30-day postoperative infection in surgically managed open and closed metacarpal and phalangeal fractures, and to determine whether open fractures treated urgently had a lower incidence of postoperative infection. METHODS: We conducted a retrospective analysis of patient demographics, comorbidities, and 30-day infection rates of patients undergoing operative fixation of metacarpal, proximal, or middle phalanx fractures from 2008 to 2015 using the American College of Surgeons' National Surgical Quality Improvement Program database...
June 13, 2018: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29908931/cost-of-surgical-treatment-for-distal-radius-fractures-and-the-implications-of-episode-based-bundled-payments
#16
Helen E Huetteman, Lin Zhong, Kevin C Chung
PURPOSE: To examine the cost of care of surgical treatment for a distal radius fracture (DRF) and develop episodes that may be used to develop future bundled payment programs. METHODS: Using 2009 to 2015 claims data from the Truven MarketScan Databases, we examined the cost of care for surgical treatment of DRFs among adult patients in the United States. We excluded patients with concurrent fractures, patients who required complex care, and patients in assisted living facilities...
June 13, 2018: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29908853/exercise-programs-may-be-effective-in-preventing-a-new-episode-of-neck-pain-a-systematic-review-and-meta-analysis
#17
Tarcisio F de Campos, Chris G Maher, Daniel Steffens, Joel T Fuller, Mark J Hancock
QUESTION: What is the effectiveness of interventions that aim to prevent a new episode of neck pain? DESIGN: Systematic review and meta-analysis of randomised, controlled trials. PARTICIPANTS: People without neck pain at study entry. INTERVENTION: Any intervention aiming to prevent a future episode of neck pain. OUTCOME MEASURES: New episode of neck pain. RESULTS: Five trials including a total of 3852 individuals met the inclusion criteria...
June 13, 2018: Journal of Physiotherapy
https://www.readbyqxmd.com/read/29908812/short-communication-lack-of-intramammary-niche-recolonization-during-a-sanitation-program-for-the-contagious-mastitis-pathogen-staphylococcus-aureus-genotype-b
#18
C Sartori, V Perreten, I Ivanovic, M C Härdi-Landerer, H U Graber
In Switzerland, sanitation programs of dairy herds infected with the contagious mastitis pathogen Staphylococcus aureus genotype B (GTB) have been established for several years. In recent years, Streptococcus uberis and non-aureus staphylococci have emerged as the bacteria most frequently isolated from bovine milk samples. The latter cause subclinical mastitis, and some species are more persistent or pathogenic than others. The present study aimed to investigate the developments in the intramammary colonization spectrum of 5 dairy herds undergoing a sanitation program for Staph...
June 13, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29908807/hepatic-phosphorylation-status-of-serine-threonine-kinase-1-mammalian-target-of-rapamycin-signaling-proteins-and-growth-rate-in-holstein-heifer-calves-in-response-to-maternal-supply-of-methionine
#19
T Xu, A S M Alharthi, F Batistel, A Helmbrecht, C Parys, E Trevisi, X Shen, J J Loor
The study investigated whether methionine supply during late pregnancy is associated with liver mammalian target of rapamycin (MTOR) pathway phosphorylation, plasma biomarkers, and growth in heifer calves born to cows fed a control diet (CON) or the control diet plus ethylcellulose rumen-protected methionine (MET; 0.09% of dry matter intake) for the last 28 d prepartum. Calves were fed and managed similarly during the first 56 d of age. Plasma was harvested at birth and 2, 7, 21, 42, and 50 d of age and was used for biomarker profiling...
June 13, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29908806/preweaned-heifer-management-on-us-dairy-operations-part-ii-factors-associated-with-colostrum-quality-and-passive-transfer-status-of-dairy-heifer-calves
#20
C B Shivley, J E Lombard, N J Urie, D M Haines, R Sargent, C A Kopral, T J Earleywine, J D Olson, F B Garry
Passive transfer of immunity is essential for the short- and long-term health of dairy calves. The objective of this study was to evaluate factors associated with colostrum quality and passive transfer status of US heifer calves. This study included 104 operations in 13 states that participated in the calf component of the National Animal Health Monitoring System's Dairy 2014 study. This 18-mo longitudinal study included 1,972 Holstein heifer calves from birth to weaning. Multivariable mixed linear regression models were selected using backward elimination model selection after univariate screening to determine which factors were associated with colostrum IgG and serum IgG concentrations...
June 13, 2018: Journal of Dairy Science
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