Verusca Najara de Carvalho Cunha, Thiago Dos Santos Rosa, Marcelo Magalhães Sales, Caio Victor Sousa, Samuel da Silva Aguiar, Lysleine Alves Deus, Herbert Gustavo Simoes, Rosangela Vieira de Andrade
Telomere shortening is associated to sarcopenia leading to functional impairment during aging. There are mechanisms associated with telomere attrition, as well to its protection and repair. Physical training is a factor that attenuates telomere shortening, but little is known about the effects of different exercise intensities on telomere biology. Thus, we evaluated the effects of exercise intensity (moderate vs. high-intensity domain) on gene expression of senescence markers Checkpoint kinase 2 and tumor suppressor ( Chk2 and p53 , respectively), shelterin telomere repeat binding 1 and 2 ( Trf1 / Trf2 ), DNA repair ( Xrcc5 ), telomerase reverse transcriptase ( mTERT ) and telomere length in middle aged mice...
September 2018: International Journal of Sports Medicine