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Adnexal tumor skin

Marcela R Jiménez, Helena Rocchetto, Paula S Ferreira, Martin Sangueza, Silvia V Lourenço, Marcello M S Nico
Syringomas are benign adnexal tumors that are characterized histologically by the presence of small solid and cystic epithelial structures in the upper half of the reticular dermis. Reflectance confocal microscopy is a noninvasive diagnostic method that enables in vivo visualization of tissues with a resolution that approximates that of conventional histopathology. The use of this method in skin imaging over the past several years has improved dermatological diagnoses, creating the potential for its wide application in such diagnoses, especially for benign and malignant skin tumors...
October 18, 2016: American Journal of Dermatopathology
Cintia Arjona Aguilera, Raquel De la Varga Martínez, Lidia Ossorio García, David Jiménez-Gallo, Cristina Albarrán Planelles, Mario Linares Barrios
Brooke-Spiegler Syndrome (BSS) is a rare genodermatosis characterized by the progressive formation of adnexal skin tumors in the scalp and face, mainly trichoepitheliomas, cylindromas, and spiradenomas. It has also been associated with salivary glands neoplasms. It is due to mutations in the tumor suppressor gene cylindromatosis (CYLD gene) localized on chromosome 16q12-q13. Around 93 mutations have been described. The study of CYLD gene in patients and their relatives is of vital importance to establish the molecular diagnosis and offer appropriate genetic counseling...
September 2016: Indian Journal of Dermatology
Eman Aljufairi, Fayek Alhilli
Merkel cell carcinoma is a rare aggressive primary cutaneous neuroendocrine tumor. It is associated mostly with malignant skin lesions. Rare cases in the literature described its association with benign skin adnexal lesions. We present here an additional case of Merkel cell carcinoma arising from an epidermal cyst located in the left arm of a 57-year-old male. The tumor was composed of lobules of monotonous round cells with dusty chromatin. It was positive for cytokeratin 20 and neuroendocrine markers. Patient was treated with surgical resection and radiation to the axilla...
September 26, 2016: American Journal of Dermatopathology
Justin A Bishop, Janis M Taube, Albert Su, Scott W Binder, Dmitry V Kazakov, Michal Michal, William H Westra
Mammary analogue secretory carcinoma is a low-grade salivary gland carcinoma that exhibits analogous features to secretory carcinoma of the breast including the presence of a t(12;15) translocation resulting in the ETV6-NTRK3 gene fusion. Rare cases of purported secretory carcinoma of the skin adnexa have been reported, but their relationship to true secretory carcinoma of the breast and salivary glands is unclear, as they generally do not harbor ETV6 rearrangements. Cases of cutaneous neoplasms with histologic features identical to secretory carcinoma of the breast and salivary glands were identified from the consultation files of 3 academic medical institutions...
September 14, 2016: American Journal of Surgical Pathology
Katherine C Rappazzo, Philip R Cohen
BACKGROUND: Hidrocystomas are benign tumors of apocrine or eccrine epithelium. They most commonly occur on the head and neck, especially periorbitally. Albeit rare, these adnexal tumors may present as pigmented lesions. PURPOSE: To describe a patient with a pigmented eccrine hidrocystoma of his nose and to review the features of other individuals with pigmented hidrocystoma of the nasal epithelium. MATERIAL AND METHODS: PubMed was used to search the follow terms: hidrocystoma and pigmented...
2016: Dermatology Online Journal
Fatima Zahra Nasreddine, Fouzia Hali, Soumiya Chiheb
Pilomatricoma is a common and benign skin tumor of childhood arising from the hair follicle matrix. It is an often misunderstood adnexal tumor, confused with other skin lesions. The most common sites of pilomatricome are the head and the neck. The aim of this study was to report a series of 22 cases with unusual forms collected in the dermatology department from January 2006 to May 2015. The study included 16 women and 6 men. The average age was 23.3 years (4- 80 years). Cervicofacial location was observed in 12 cases, 2 patients had multiple locations, a 4 year-old boy had frontotemporal location, a 14 year-old girl had face and forearm location and a 48 year-old patient had subungual location...
2016: Pan African Medical Journal
Nicola di Meo, Giuseppe Stinco, Alessandro Gatti, Mattia Fadel, Silvia Vichi, Giusto Trevisan
Dear Editor, Apocrine hidradenoma is a rare benign adnexal tumor related to the more common poroma, as they both originate from sweat glands. Hidradenoma usually has an eccrine differentiation, but an apocrine differentiation is possible. Due to its rarity and non-specific clinical appearance it is difficult to differentiate it from other malignant cutaneous lesions. In this challenging task, dermatoscopy could be particularly helpful to better describe, recognize, and differentiate these lesions. Unfortunately, the literature offers only few dermatoscopic descriptions of this rare cutaneous neoplasm...
June 2016: Acta Dermatovenerologica Croatica: ADC
Priyanka Chand, Pratima Khare, Renu Gupta, Sonam Kumar Pruthi, Mukta Ahuja, Aditi Jha
BACKGROUND: The diagnosis of skin adnexal tumors is usually based on histopathology. However, fine-needle aspiration cytology (FNAC) can be of great help and shows a high degree of correlation to the final diagnosis. It is helpful in many situations where skin lesions are a manifestation of certain systemic syndromes and aids to the formation of precise treatment plans. MATERIALS AND METHODS: This prospective study was carried out to assess the diagnosis of skin adnexal tumors based on FNAC and their comparison with histopathological diagnoses...
2016: Acta Cytologica
Marino Antonio Capurso-García, Verónica Bautista-Piña, Alan Pomerantz, Javier Andrés Galnares-Olalde, Ruben Blachman-Braun, Sergio Rodríguez-Rodríguez, Monica Goldberg-Murow
Proliferating trichilemmal tumors (PTTs) are benign adnexal skin neoplasms that arise from the outer root sheath of the hair follicle. These tumors are most commonly observed on the scalp and occur, most of the time, in elderly women. Malignant transformation of these neoplasms is a rare event; less than 50 cases have been reported in the English medical literature. We present the case of a 39-year-old Hispanic woman with a tumor located on the skin of one of her breasts that in her third surgical procedure the histologic examination revealed the presence of a malignant proliferating trichilemmal tumor (MPTT)...
2016: Case Reports in Oncological Medicine
A M Stowman, M M Griffin, W A Kanner, G Tchernev, A A Chokoeva, U Wollina, T Lotti, M Fioranelli, M G Roccia, G K Maximov, J W Patterson
Trichilemmoma and trichoblastoma are benign adnexal neoplasms derived from the hair follicle unit. While trichilemmomas are closely associated with the epidermis, trichoblastomas are found within the dermis and subcutaneous tissue. Both tumors have been reported to arise within nevus sebaceus of Jadassohn (NSJ). We present a 42-year-old white male with a 5 mm crusted, erythematous papule on the right occipital scalp that had been present for years. A shave biopsy was performed and read as trichilemmoma involving the biopsy base...
April 2016: Journal of Biological Regulators and Homeostatic Agents
Hazem M Abdel Tawab, Khalid F Amish, Ibrahim A Sulaiman, Rubyath C Rajib
Syringocystadenomapapilliferum is an extremely rare benign adnexal tumor of the scalp and face region. This is a report of the case of a female patient with syringocystadenomapapilliferum originating from the bony cartilaginous junction of the external auditory canal. A provisional diagnosis of an inflammatory polyp was made based on the clinical and radiological findings. Diagnosis was established only after the histopathological examination. This article represents a report of a rare skin disease and a rare site of affection...
April 2016: Journal of International Advanced Otology
Indu Manicketh, Rekha Singh, Prasit Kumar Ghosh
Cylindroma is a benign skin adnexal tumor of eccrine differentiation. Clinically, they are disfiguring lesions that can mimic a malignancy. Cylindromas can be single or multiple and commonly involve the scalp (turban tumor) and face. Multiple cylindromas can have a syndromic association as seen in Brooke-Spiegler syndrome and familial cylindromatosis. We present a case of non familial cylindroma of the face that clinically mimicked a basal cell carcinoma. The histopathology was confirmatory. Herein we also highlight the utility of a simple and inexpensive histochemical stain Periodic Acid Schiff in supporting the diagnosis...
May 2016: Indian Dermatology Online Journal
Anne M Mills, Maria Luisa C Policarpio-Nicholas, Abbas Agaimy, Mark R Wick, Stacey E Mills
Microcystic adnexal carcinoma (MAC) occurs predominantly in the centrofacial skin and has been only rarely reported in mucosal surfaces. We here present a 5 case series of tumors closely resembling MAC occurring in the mucosal surfaces of the head and neck, which we have termed sclerosing microcystic adenocarcinomas. These tumors showed a predilection for women (4:1) with an average patient age of 52.6 years (range 41-73 years). Location included the tongue (n = 2), the floor of the mouth (n = 2), and the nasopharynx/clivus (n = 1)...
May 27, 2016: Head and Neck Pathology
Maria J Suarez, Roxana Rivera-Michlig, Sander Dubovy, Fausto J Rodriguez
BACKGROUND: Patients with xeroderma pigmentosum (XP) are strongly predisposed to the development of numerous cutaneous cancers. However, the extent of ocular pathology in these patients has not been adequately studied. METHODS: We conducted a retrospective study of tumors involving the ocular surface and ocular adnexa from 6 XP patients. Histopathological evaluation and immunohistochemistry was performed using antibodies directed against the most common mutated proteins in XP (XPA, XPC, and XPD)...
December 2015: Ocular Oncology and Pathology
Paul Ikgan Sia, Edwin Figueira, Alexandra Allende, Dinesh Selva
Malignant hair follicle tumors are rare skin adnexal malignancies that have a predilection for the head and neck region. They can be categorized into a number of different subtypes. Histologically, they are distinct from their benign counterpart. To the best of our knowledge, there is no extensive review of these malignancies, especially in the periorbital region. We aim to provide a literature review and a guideline for management of these malignant tumors in the periorbital region. Database from Medline, PubMed, Embase, and Google Scholar were consulted...
June 2016: Orbit
Manuela Hirz, Christiane Herden
The diagnosis of malignant melanoma can be difficult because these tumors can be amelanotic and may contain diverse variants and divergent differentiations, of which the signet-ring cell subtype is very rare and has only been described in humans, dogs, cats, and a hamster. We describe herein histopathologic and immunohistochemical approaches taken to diagnose a case of signet-ring cell malignant melanoma with myofibroblastic differentiation in a cat. A tumor within the abdominal skin of a 2-year-old cat was composed of signet-ring cells and irregularly interwoven streams of spindle cells...
July 2016: Journal of Veterinary Diagnostic Investigation
Jonathan J Lopez, Beiyun Chen, Karthik Ghosh, Margot S Peters
Malignant proliferating tricholemmal tumor (MPTT) is a rare adnexal neoplasm most commonly located on the scalp. We a 62-year-old woman who presented to her local physician with a palpable but not visible nodule of the left breast, initially diagnosed as squamous cell carcinoma. Histopathological evaluation of the reexcision specimen incidentally revealed ductal carcinoma in situ. On referral to our institution, the skin biopsy specimen was reviewed and interpreted as a low-grade MPTT. This patient and 2 previously reported cases of MPTT involving breast skin highlight presentation of a rare tumor at an unusual site and the potential for misdiagnosis as squamous cell carcinoma...
October 2016: American Journal of Dermatopathology
Jacob Pe'er
The eyelids are composed of four layers: skin and subcutaneous tissue including its adnexa, striated muscle, tarsus with the meibomian glands, and the palpebral conjunctiva. Benign and malignant tumors can arise from each of the eyelid layers. Most eyelid tumors are of cutaneous origin, mostly epidermal, which can be divided into epithelial and melanocytic tumors. Benign epithelial lesions, cystic lesions, and benign melanocytic lesions are very common. The most common malignant eyelid tumors are basal cell carcinoma in Caucasians and sebaceous gland carcinoma in Asians...
March 2016: Indian Journal of Ophthalmology
Erica R Ghareeb, Brittany O Dulmage, John A Vargo, Goundappa K Balasubramani, Sushil Beriwal
BACKGROUND: Consensus guidelines have defined select less common skin cancers appropriate for Mohs micrographic surgery (MMS), as these tumors are characterized by asymmetric growth patterns that challenge conventional surgical extirpation of disease. OBJECTIVE: The authors aimed to define surgical patterns of care and to identify factors affecting treatment selection in the United States. MATERIALS AND METHODS: Retrospective cohort analysis of nonmetastatic nonmelanoma skin cancers deemed appropriate for MMS by American Academy of Dermatology/American College of Mohs Surgery/American Society for Dermatologic Surgery Association/American Society for Mohs Surgery appropriate use criteria from the National Cancer Data Base from 1998 to 2012...
May 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
Lisa M Rooper, Jeffrey S Iding, Jonathan D Cuda, Syed Z Ali
BACKGROUND: Fine-needle aspiration (FNA) is well-established as an accurate technique for the diagnosis of palpable breast masses. While the differential diagnosis of such lesions usually focuses on benign or malignant mammary proliferations, a subset of breast neoplasms arises from skin and soft tissue. Skin adnexal neoplasms such as hidradenoma can pose a particular pitfall on breast FNA cytology (FNAC) as epithelial proliferations that are not of ductal or lobular origin. CASE: A 59-year-old female presented with a superficial breast mass...
2016: Acta Cytologica
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