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https://www.readbyqxmd.com/read/28195265/solid-papillary-carcinoma-of-the-nipple-an-in-situ-carcinoma-or-an-expansive-growth-tumor
#1
D Tacchini, L Vassallo, M A G M Butorano, V Mancini, T Megha
Papillary breast lesions are a heterogeneous group of tumors which mainly arise in the central mammary region, ranging from benign to malignant. Among them, solid papillary carcinoma (SPC) represents a very uncommon variant with indolent clinical behavior and excellent prognosis. The categorization of papillary lesions as benign, atypical or malignant is often difficult even for experienced pathologists. Furthermore, for prognostic purposes, to decide whether to consider a lesions as in situ when it is not associated with frank invasive foci of carcinoma may be problematic...
September 2016: Pathologica
https://www.readbyqxmd.com/read/28182081/cytopathologic-features-of-an-unusual-case-of-multiple-eccrine-spiradenomas-misdiagnosed-as-a-malignant-round-cell-tumor
#2
Bharat Rekhi, Archi Agarwal
A 28-year-old lady presented with multiple swellings in her left shoulder, associated with intermittent pain since last one and a half years. Radiologic imaging revealed multiple, well-defined, subcutaneous lesions in her left supraclavicular region. Fine needle aspiration cytology (FNAC) smears were initially reported as Ewing sarcoma, elsewhere. On review, the smears showed cohesive clusters of round-to-oval cells with scant cytoplasm, which were focally arranged in an acinar-rosetting pattern around hyaline "droplets/bodies," along with few scattered lymphocytes against a background of red blood cells...
January 2017: Journal of Cytology
https://www.readbyqxmd.com/read/28178009/isolated-ectopic-cutaneous-atypical-meningioma-of-the-scalp-another-mimicker-of-primary-adnexal-tumor
#3
Jonathan Konopinski, Victor G Prieto, Doina Ivan, Priyadharsini Nagarajan, Michael T Tetzlaff, Jonathan L Curry, Carlos A Torres-Cabala, Gregory N Fuller, Phyu P Aung
Cutaneous meningiomas are rare tumors most commonly located in the skin and soft tissue of the scalp. They may be congenital (type I), acquired and derived from ectopic arachnoid tissue in the skin (type II), or arise through direct extension from an intracranial meningioma (type III). Despite their well-established documentation in the literature, they may escape recognition when classic features are not present. Herein, we present a case of a cutaneous atypical meningioma (≥4 mitotic figures/10 High Power Fields (HPF)) on the posterior scalp of a 31-year-old man with histologic features mimicking a malignant adnexal tumor...
January 25, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28121520/a-rare-case-of-hydrocystoma-of-the-labial-commissure-histopathology-and-clinical-picture
#4
Francesca Angiero, Franco Ferrante, Rolando Crippa, Andrea Ottonello, Stefania Mauro, Maria Gabriella Valente
OBJECTIVE: Hydrocystomas (HCs) are rare, benign, skin adnexal cystic tumors that may be either eccrine or apocrine. BACKGROUND DATA: Apocrine-HCs are cystic lesions that arise from the apocrine secretory coil, whereas eccrine-HCs are retention cysts of the eccrine duct. The commonest site is around the eyes, on the ears, scalp, chest, shoulders, or feet; HCs of the oral cavity are very rare. METHODS: The case is reported of a 36 year-old man with a nodular lesion that was 7 × 5 mm in size on the labial commissure...
January 24, 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/28027201/incidence-and-clinical-features-of-rare-cutaneous-malignancies-in-olmsted-county-minnesota-2000-to-2010
#5
Stanislav N Tolkachjov, Adam R Schmitt, John G Muzic, Amy L Weaver, Christian L Baum
BACKGROUND: The incidence of rare cutaneous malignancies is unknown. Current estimates of rare cutaneous malignancy incidences are based on broad epidemiologic data or single institution experiences, not population-based data. OBJECTIVE: To determine the incidence of several rare nonmelanoma skin cancers. MATERIALS AND METHODS: The authors conducted a retrospective chart review of a population-based cohort between the years 2000 and 2010. Residents of Olmsted County, Minnesota, who were diagnosed with a biopsy-proven nonmelanoma skin cancer-excluding basal cell carcinoma and squamous cell carcinoma-were included in this study...
January 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28000303/primary-cutaneous-histiocytoid-carcinoma-with-distant-metastasis
#6
Rebecca Philips, Leila Langston, Helena Hwang, Travis Vandergriff, Tanya Trynosky, Alma C Berlingeri-Ramos
Distinguishing primary cutaneous adnexal carcinoma from metastatic carcinoma of unknown primary can be a diagnostic challenge due to the frequent overlap of histologic and immunohistochemical features. A 58-year-old man presented with a tender, indurated plaque on axillary skin. Biopsy revealed infiltrating atypical cells throughout the dermis, without connection to the epidermis. Tumor cells had a histiocytoid appearance and displayed mild pleomorphism. The tumor was discohesive and had areas with a single file pattern...
December 21, 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27759695/evaluation-of-syringomas-by-in-vivo-reflectance-confocal-microscopy-a-report-of-two-cases
#7
Marcela R Jiménez, Helena Rocchetto, Paula S Ferreira, Martin Sangueza, Silvia V Lourenço, Marcello M S Nico
Syringomas are benign adnexal tumors that are characterized histologically by the presence of small solid and cystic epithelial structures in the upper half of the reticular dermis. Reflectance confocal microscopy is a noninvasive diagnostic method that enables in vivo visualization of tissues with a resolution that approximates that of conventional histopathology. The use of this method in skin imaging over the past several years has improved dermatological diagnoses, creating the potential for its wide application in such diagnoses, especially for benign and malignant skin tumors...
October 18, 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/27688459/heterozygous-cylindromatosis-gene-mutation-c-1628_1629delct-in-a-family-with-brook-spiegler-syndrome
#8
Cintia Arjona Aguilera, Raquel De la Varga Martínez, Lidia Ossorio García, David Jiménez-Gallo, Cristina Albarrán Planelles, Mario Linares Barrios
Brooke-Spiegler Syndrome (BSS) is a rare genodermatosis characterized by the progressive formation of adnexal skin tumors in the scalp and face, mainly trichoepitheliomas, cylindromas, and spiradenomas. It has also been associated with salivary glands neoplasms. It is due to mutations in the tumor suppressor gene cylindromatosis (CYLD gene) localized on chromosome 16q12-q13. Around 93 mutations have been described. The study of CYLD gene in patients and their relatives is of vital importance to establish the molecular diagnosis and offer appropriate genetic counseling...
September 2016: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/27673388/merkel-cell-carcinoma-arising-in-an-epidermal-cyst
#9
Eman Aljufairi, Fayek Alhilli
Merkel cell carcinoma is a rare aggressive primary cutaneous neuroendocrine tumor. It is associated mostly with malignant skin lesions. Rare cases in the literature described its association with benign skin adnexal lesions. We present here an additional case of Merkel cell carcinoma arising from an epidermal cyst located in the left arm of a 57-year-old male. The tumor was composed of lobules of monotonous round cells with dusty chromatin. It was positive for cytokeratin 20 and neuroendocrine markers. Patient was treated with surgical resection and radiation to the axilla...
September 26, 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/27631515/secretory-carcinoma-of-the-skin-harboring-etv6-gene-fusions-a-cutaneous-analogue-to-secretory-carcinomas-of-the-breast-and-salivary-glands
#10
Justin A Bishop, Janis M Taube, Albert Su, Scott W Binder, Dmitry V Kazakov, Michal Michal, William H Westra
Mammary analogue secretory carcinoma is a low-grade salivary gland carcinoma that exhibits analogous features to secretory carcinoma of the breast including the presence of a t(12;15) translocation resulting in the ETV6-NTRK3 gene fusion. Rare cases of purported secretory carcinoma of the skin adnexa have been reported, but their relationship to true secretory carcinoma of the breast and salivary glands is unclear, as they generally do not harbor ETV6 rearrangements. Cases of cutaneous neoplasms with histologic features identical to secretory carcinoma of the breast and salivary glands were identified from the consultation files of 3 academic medical institutions...
January 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27617522/pigmented-hidrocystoma-of-nasal-epithelium-phone-report-of-a-man-with-a-pigmented-hidrocystoma-of-his-nose-and-literature-review
#11
Katherine C Rappazzo, Philip R Cohen
BACKGROUND: Hidrocystomas are benign tumors of apocrine or eccrine epithelium. They most commonly occur on the head and neck, especially periorbitally. Albeit rare, these adnexal tumors may present as pigmented lesions. PURPOSE: To describe a patient with a pigmented eccrine hidrocystoma of his nose and to review the features of other individuals with pigmented hidrocystoma of the nasal epithelium. MATERIAL AND METHODS: PubMed was used to search the follow terms: hidrocystoma and pigmented...
May 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/27516819/-pilomatricoma-a-study-of-22-cases
#12
Fatima Zahra Nasreddine, Fouzia Hali, Soumiya Chiheb
Pilomatricoma is a common and benign skin tumor of childhood arising from the hair follicle matrix. It is an often misunderstood adnexal tumor, confused with other skin lesions. The most common sites of pilomatricome are the head and the neck. The aim of this study was to report a series of 22 cases with unusual forms collected in the dermatology department from January 2006 to May 2015. The study included 16 women and 6 men. The average age was 23.3 years (4- 80 years). Cervicofacial location was observed in 12 cases, 2 patients had multiple locations, a 4 year-old boy had frontotemporal location, a 14 year-old girl had face and forearm location and a 48 year-old patient had subungual location...
2016: Pan African Medical Journal
https://www.readbyqxmd.com/read/27477180/dermoscopy-of-skin-adnexal-neoplasms-a-continuous-challenge
#13
Nicola di Meo, Giuseppe Stinco, Alessandro Gatti, Mattia Fadel, Silvia Vichi, Giusto Trevisan
Dear Editor, Apocrine hidradenoma is a rare benign adnexal tumor related to the more common poroma, as they both originate from sweat glands. Hidradenoma usually has an eccrine differentiation, but an apocrine differentiation is possible. Due to its rarity and non-specific clinical appearance it is difficult to differentiate it from other malignant cutaneous lesions. In this challenging task, dermatoscopy could be particularly helpful to better describe, recognize, and differentiate these lesions. Unfortunately, the literature offers only few dermatoscopic descriptions of this rare cutaneous neoplasm...
June 2016: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/27450457/diagnostic-evaluation-of-skin-adnexal-tumors-by-fine-needle-aspiration-cytology
#14
Priyanka Chand, Pratima Khare, Renu Gupta, Sonam Kumar Pruthi, Mukta Ahuja, Aditi Jha
BACKGROUND: The diagnosis of skin adnexal tumors is usually based on histopathology. However, fine-needle aspiration cytology (FNAC) can be of great help and shows a high degree of correlation to the final diagnosis. It is helpful in many situations where skin lesions are a manifestation of certain systemic syndromes and aids to the formation of precise treatment plans. MATERIALS AND METHODS: This prospective study was carried out to assess the diagnosis of skin adnexal tumors based on FNAC and their comparison with histopathological diagnoses...
2016: Acta Cytologica
https://www.readbyqxmd.com/read/27403361/atypical-proliferating-trichilemmal-cyst-with-malignant-breast-skin-transformation-a-case-report-and-review-of-the-literature
#15
Marino Antonio Capurso-García, Verónica Bautista-Piña, Alan Pomerantz, Javier Andrés Galnares-Olalde, Ruben Blachman-Braun, Sergio Rodríguez-Rodríguez, Monica Goldberg-Murow
Proliferating trichilemmal tumors (PTTs) are benign adnexal skin neoplasms that arise from the outer root sheath of the hair follicle. These tumors are most commonly observed on the scalp and occur, most of the time, in elderly women. Malignant transformation of these neoplasms is a rare event; less than 50 cases have been reported in the English medical literature. We present the case of a 39-year-old Hispanic woman with a tumor located on the skin of one of her breasts that in her third surgical procedure the histologic examination revealed the presence of a malignant proliferating trichilemmal tumor (MPTT)...
2016: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/27373129/coexistent-trichilemmoma-and-trichoblastoma-without-associated-nevus-sebaceus
#16
A M Stowman, M M Griffin, W A Kanner, G Tchernev, A A Chokoeva, U Wollina, T Lotti, M Fioranelli, M G Roccia, G K Maximov, J W Patterson
Trichilemmoma and trichoblastoma are benign adnexal neoplasms derived from the hair follicle unit. While trichilemmomas are closely associated with the epidermis, trichoblastomas are found within the dermis and subcutaneous tissue. Both tumors have been reported to arise within nevus sebaceus of Jadassohn (NSJ). We present a 42-year-old white male with a 5 mm crusted, erythematous papule on the right occipital scalp that had been present for years. A shave biopsy was performed and read as trichilemmoma involving the biopsy base...
April 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/27340997/syringocystadenomapapilliferum-arising-from-the-external-auditory-canal-a-rare-tumor-in-a-rare-site
#17
Hazem M Abdel Tawab, Khalid F Amish, Ibrahim A Sulaiman, Rubyath C Rajib
Syringocystadenomapapilliferum is an extremely rare benign adnexal tumor of the scalp and face region. This is a report of the case of a female patient with syringocystadenomapapilliferum originating from the bony cartilaginous junction of the external auditory canal. A provisional diagnosis of an inflammatory polyp was made based on the clinical and radiological findings. Diagnosis was established only after the histopathological examination. This article represents a report of a rare skin disease and a rare site of affection...
April 2016: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/27294061/eccrine-cylindroma-of-the-face-and-scalp
#18
Indu Manicketh, Rekha Singh, Prasit Kumar Ghosh
Cylindroma is a benign skin adnexal tumor of eccrine differentiation. Clinically, they are disfiguring lesions that can mimic a malignancy. Cylindromas can be single or multiple and commonly involve the scalp (turban tumor) and face. Multiple cylindromas can have a syndromic association as seen in Brooke-Spiegler syndrome and familial cylindromatosis. We present a case of non familial cylindroma of the face that clinically mimicked a basal cell carcinoma. The histopathology was confirmatory. Herein we also highlight the utility of a simple and inexpensive histochemical stain Periodic Acid Schiff in supporting the diagnosis...
May 2016: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/27233253/sclerosing-microcystic-adenocarcinoma-of-the-head-and-neck-mucosa-a-neoplasm-closely-resembling-microcystic-adnexal-carcinoma
#19
Anne M Mills, Maria Luisa C Policarpio-Nicholas, Abbas Agaimy, Mark R Wick, Stacey E Mills
Microcystic adnexal carcinoma (MAC) occurs predominantly in the centrofacial skin and has been only rarely reported in mucosal surfaces. We here present a 5 case series of tumors closely resembling MAC occurring in the mucosal surfaces of the head and neck, which we have termed sclerosing microcystic adenocarcinomas. These tumors showed a predilection for women (4:1) with an average patient age of 52.6 years (range 41-73 years). Location included the tongue (n = 2), the floor of the mouth (n = 2), and the nasopharynx/clivus (n = 1)...
December 2016: Head and Neck Pathology
https://www.readbyqxmd.com/read/27172099/clinicopathological-features-of-ophthalmic-neoplasms-arising-in-the-setting-of-xeroderma-pigmentosum
#20
Maria J Suarez, Roxana Rivera-Michlig, Sander Dubovy, Fausto J Rodriguez
BACKGROUND: Patients with xeroderma pigmentosum (XP) are strongly predisposed to the development of numerous cutaneous cancers. However, the extent of ocular pathology in these patients has not been adequately studied. METHODS: We conducted a retrospective study of tumors involving the ocular surface and ocular adnexa from 6 XP patients. Histopathological evaluation and immunohistochemistry was performed using antibodies directed against the most common mutated proteins in XP (XPA, XPC, and XPD)...
December 2015: Ocular Oncology and Pathology
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