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Adnexal tumor skin

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https://www.readbyqxmd.com/read/28937387/malignant-chondroid-syringoma-of-thigh-with-late-metastasis-to-lung-a-very-rare-case-report
#1
Mayur Kothiya, Neha Mittal, Rajiv Kumar, Shubhada Kane
Mixed/biphasic tumors include epithelial-myoepithelial tumors, pleomorphic adenoma, matrix-producing tumors, cutaneous mixed tumors such as chondroid syringoma (CS), malignant mixed tumors (carcinosarcomas), pulmonary blastomas (in lung), and many others. Morphology may show overlap between various mixed tumors. At any particular site, whether these tumors are primary or metastasis from other sites is difficult to determine, more so if primary is unknown or not disclosed. CS is a rare benign mixed/biphasic skin adnexal tumor, considered as cutaneous counterpart of pleomorphic adenoma...
July 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/28841778/dermatopathology-101-part-2-skin-tumors
#2
Julia Liersch, Amelie von Köckritz, Jörg Schaller
The present CME article highlights fundamental aspects with respect to the histopathology of the most common skin tumors (epidermal, adnexal, melanocytic, and mesenchymal), their laboratory workup, as well as the importance of supplementary immunohistochemical and molecular studies. The information provided is meant to assist experienced clinicians in choosing the correct biopsy technique and in interpreting dermatopathology reports, and to provide dermatology residents with a better understanding of dermatopathology...
September 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28794552/histopathological-analysis-of-skin-adnexal-tumors-a-three-year-study-of-110-cases-at-a-tertiary-care-center
#3
Kanwalpreet Kaur, Karuna Gupta, Deepika Hemrajani, Ajay Yadav, Kalpana Mangal
BACKGROUND: Skin adnexal tumors (SAT) encompass wide spectrum of benign and malignant tumors that differentiate toward one or more adnexal structures found in normal skin. Overall incidence of SATs is low yet they can be challenging to diagnose. AIMS: The aim of this study is to study the spectrum and microscopic features of SATs. MATERIALS AND METHODS: It was a retrospective cross-sectional, descriptive study conducted over a period of 3 years...
July 2017: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/28772003/case-of-chondroid-syringoma-mimicking-as-nodular-hidradenoma-a-diagnostic-pitfall-on-cytopathology
#4
Bahadur Shalini, Katyal Akshi, Nargotra Namrata, Soni Shilpi, Nain Manupriya
Limited literature is available on the use of fine needle aspiration (FNA) for skin tumors. Awareness of cytological features of these lesions is important to prevent misdiagnosis. A 45-year-old male, presented with slowly growing swelling over the thigh since 4 years. FNA from multiple sites yielded highly cellular smears with a dual cell population consisting of cells with small round nucleus scanty cytoplasm and polygonal cells with moderate to abundant cytoplasm. Extracellular basement membrane like material was also noted...
August 3, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28681210/sebaceous-carcinoma-a-review-of-the-scientific-literature
#5
REVIEW
Thomas Knackstedt, Faramarz H Samie
Sebaceous carcinoma is a rare and potentially aggressive cutaneous malignancy. Commonly reported in the periocular area and the head and neck region, sebaceous carcinoma can arise from any sebaceous gland in the skin. The clinical presentation may be nonspecific, and a biopsy is important to establish a diagnosis and to differentiate from mimickers including benign sebaceous neoplasms, other adnexal tumors, and basal cell carcinoma. A diagnosis of Muir Torre syndrome should be considered in patients presenting with a sebaceous neoplasm...
August 2017: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/28570391/spiradenocarcinoma-a-comprehensive-data-review
#6
Roxane D Staiger, Birgit Helmchen, Claudia Papet, Diana Mattiello, Urs Zingg
INTRODUCTION: Spiradenocarcinomas (SCs) are rare and potentially aggressive skin adnexal tumors. Optimal treatment has not yet been established. Experiences with this carcinoma are mostly presented in case reports and few case series. OBJECTIVE: To generate to a synopsis of published data on SC with regard to diagnostic procedures, treatment, and outcome. RESULTS: Median patient age was 60 years and sex distribution was balanced. Tumor manifestations were evenly distributed within the sweat gland carrying skin...
October 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28561682/advances-in-the-treatment-of-advanced-extracutaneous-melanomas-and-nonmelanoma-skin-cancers
#7
Kimberly M Komatsubara, Joanne Jeter, Richard D Carvajal, Kim Margolin, Dirk Schadendorf, Axel Hauschild
Cutaneous malignancies make up the greatest proportion of all human cancers and include melanomas as well as nonmelanoma skin cancers (NMSCs) such as basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC), as well as less common Merkel cell carcinoma (MCC), cutaneous lymphomas, cutaneous adnexal tumors, Kaposi sarcomas, and other sarcomas. Each of these NMSCs differ significantly in biology, clinical behavior, and optimal treatment recommendations from each other and from cutaneous melanoma...
2017: American Society of Clinical Oncology Educational Book
https://www.readbyqxmd.com/read/28503344/adnexal-tumors-of-skin-an-experience-at-a-tertiary-care-center-at-delhi
#8
M Pujani, G B Madaan, Z S Jairajpuri, S Jetley, M J Hassan, S Khan
BACKGROUND: Adnexal skin tumors are a heterogeneous group of uncommon tumors usually misdiagnosed clinically due to a huge variety of types and their variants. Histopathology usually helps in establishing the diagnosis. AIMS: The study was undertaken to analyze the morphological, clinical, and histological features of adnexal tumors (ATs) of the skin at our center over a period of 4 years. SUBJECTS AND METHODS: retrospective study was conducted over a period of 4 years (April 2010-March 2014), comprising 25 ATs of skin diagnosed in the Department of Pathology, Hamdard Institute of Medical Sciences and Research, Jamia Hamdard, New Delhi...
September 2016: Annals of Medical and Health Sciences Research
https://www.readbyqxmd.com/read/28497640/polarizable-crystals-in-apocrine-sweat-gland-tumors-a-series-of-3-cases
#9
Gina Johnson, Jerad M Gardner, Sara C Shalin
Polarizable calcium oxalate (CaOx) crystals have been well documented in breast biopsies, generally associated with benign apocrine metaplasia. In contrast, polarizable crystals are only rarely reported in skin adnexal neoplasms. We report 3 different cases of sweat gland tumors with polarizable crystals morphologically suggestive of CaOx: 1 apocrine hidrocystoma and 2 tubular apocrine adenomas. The histologic features were examined in 3 cases. Clinical presentation summary included 2 males and 1 female, ages 53 to 74 years, with lesions located on the left cheek, inferior vertex scalp and the left eyebrow...
May 12, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28475519/genomic-assessment-of-blitz-nevi-suggests-classification-as-a-subset-of-blue-nevus-rather-than-spitz-nevus-clinical-histopathologic-and-molecular-analysis-of-18-cases
#10
Maria C Isales, Alexandra M Haugh, Jeffrey Bubley, Anna E Verzì, Bin Zhang, Emily Kudalkar, Christina Y Lee, Pedram Yazdan, Joan Guitart, Pedram Gerami
Blitz nevi/tumors are a distinct subset of melanocytic neoplasia which show mixed morphologic features of Spitz and blue nevus. Genomically, most blue nevi have GNAQ or GNA11 mutations while most Spitzoid neoplasms have either an HRAS mutation or translocations involving MET, ROS, BRAF, ALK1, NTRK1, and RET. The criteria used for the assessment of malignancy in blue and Spitzoid lesions are different, and these lesions have different prognostic markers. In this study, we assess the clinical, morphological, and genomic changes in 18 cases of Blitz nevi/tumors to better characterize this subset of neoplasms and determine their optimal genomic classification...
April 27, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28474476/fine-needle-aspiration-cytology-in-primary-cutaneous-tumors
#11
Vani Bharani, Rajesh Kumar, Nalini Gupta, Radhika Srinivasan, Arvind Rajwanshi, Uma Nahar, Pranab Dey
BACKGROUND: Fine-needle aspiration biopsy (FNAB) is occasionally used in the evaluation of primary skin tumors. However, in routine evaluation of any soft tissue swelling we encounter the cases of skin lesions. It is essential to know FNAB features of skin lesions. MATERIALS AND METHODS: We present detailed cytomorphologic features with histologic correlation of 28 primary skin tumors, evaluated over a period of 4 years. RESULT: An accurate diagnosis was provided in 42...
May 4, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28417484/well-differentiated-neuroendocrine-tumors-in-skin-terminology-and-diagnostic-utility-of-cytokeratin-5-6-and-p63
#12
Gauri Panse, Shawn E Cowper, David J Leffell, Melissa Pulitzer, Christine J Ko
BACKGROUND: Well-differentiated neuroendocrine tumors (WDNETs) in skin include metastases from visceral primary sites and very uncommonly, primary cutaneous carcinoid tumors. Cutaneous WDNET may present a diagnostic challenge and in particular can be mistaken for a benign skin adnexal tumor. In contrast to cutaneous adnexal tumors, metastatic adenocarcinomas to the skin are cytokeratin 5/6 (CK5/6) and p63 negative in the majority of cases. It is unclear if failure to stain with CK5/6 and p63 would be helpful in differentiating WDNETs from cutaneous adnexal neoplasms...
June 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28414587/non-melanoma-skin-cancer-new-and-future-synthetic-drug-treatments
#13
REVIEW
Teresa Amaral, Claus Garbe
Non-melanoma skin cancers (NMSC) mainly comprise two different entities: basal cell carcinoma (BCC) and squamous cell carcinoma (SCC); beneath these two entities, Merkel cell carcinoma, adnexal tumors, dermatofibrosarcoma protuberans, angiosarcoma, and cutaneous lymphoma belong to NMSC. These rare skin tumors are not the topic of this review. BCC and SCC are the most common cancers diagnosed in humans. The preferred treatment is surgery, which in most cases is curative. Although a high recurrence rate is seen, these cancers rarely metastasize...
May 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/28394798/sox10-and-dog1-expression-in-primary-adnexal-tumors-of-the-skin
#14
Cecilia Lezcano, Jonhan Ho, Raja R Seethala
Primary skin adnexal tumors can be challenging to classify and must be discerned from cutaneous adenocarcinoma metastases from various sites. We evaluated expression of Sox10 and DOG1 in normal cutaneous adnexa and in 194 primary skin adnexal tumors, and compared their performance in discriminating primary skin adnexal tumors from cutaneous metastatic adenocarcinomas with that of p40 and p63. In normal skin adnexa, we noted Sox10 expression in both the secretory and myoepithelial cells in eccrine glands, but only in myoepithelial cells in apocrine glands...
March 27, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28342837/-malignant-cutaneous-adnexal-neoplasms-of-the-face-and-scalp-diagnostic-and-therapeutic-update
#15
M Romeu, J M Foletti, C Chossegros, J P Dales, P Berbis, B Cribier, L Guyot
INTRODUCTION: Malignant cutaneous adnexal neoplasms are rare and have been characterized only recently. They can occur at any age but preferentially in elderly. There are 3 of them: trichoblastic carcinoma, trichilemmal carcinoma and malignant pilomatricoma. The aim of our study was to make a diagnostic and therapeutic update about these tumors when located at the face or at the scalp. MATERIALS AND METHODS: A bibliographic research was made on PubMed using following keywords: appendage skin carcinoma AND pathology AND/OR therapeutic...
April 2017: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28299221/endocrine-mucin-producing-sweat-gland-carcinoma-a-histological-challenge
#16
Mary Anne Brett, Samih Salama, Gabriella Gohla, Salem Alowami
Endocrine mucin-producing sweat gland carcinoma (EMPSGC) is a rare adnexal tumor of the skin with low-grade cytological features and neuroendocrine differentiation. It has a predilection for the skin of the eyelid, but has also been reported in the face and rarely extra-facial locations. The tumor is seen more frequently in women and on average affects the elderly. It is histologically and immunohistochemically analogous to solid papillary carcinoma of the breast/endocrine ductal carcinoma in situ with a nodular, solid, papillary, and/or cribriforming architecture, neuroendocrine differentiation, and mucin production...
2017: Case Reports in Pathology
https://www.readbyqxmd.com/read/28284233/retrospective-study-of-rare-cutaneous-malignant-adnexal-tumors-of-the-head-and-neck-in-a-tertiary-care-cancer-hospital-a-case-series
#17
Omer Waqas, Muhammad Faisal, Irfan Haider, Awais Amjad, Arif Jamshed, Raza Hussain
BACKGROUND: Adnexal tumors of the skin are a large and diverse group of benign and malignant neoplasms, which exhibit morphological differentiation toward one of the different types of adnexal epithelium present in normal skin and they pose a diagnostic challenge. The purpose of this study is to share our experience with these rare but aggressive tumors at a tertiary care cancer hospital in a developing country. A retrospective review of 11 patients diagnosed with rare adnexal tumors and their variants from January 2005 to December 2014, treated either surgically or non-surgically, was performed to describe the clinicopathological characteristics and outcome of the disease...
March 12, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28195265/solid-papillary-carcinoma-of-the-nipple-an-in-situ-carcinoma-or-an-expansive-growth-tumor
#18
D Tacchini, L Vassallo, M A G M Butorano, V Mancini, T Megha
Papillary breast lesions are a heterogeneous group of tumors which mainly arise in the central mammary region, ranging from benign to malignant. Among them, solid papillary carcinoma (SPC) represents a very uncommon variant with indolent clinical behavior and excellent prognosis. The categorization of papillary lesions as benign, atypical or malignant is often difficult even for experienced pathologists. Furthermore, for prognostic purposes, to decide whether to consider a lesions as in situ when it is not associated with frank invasive foci of carcinoma may be problematic...
September 2016: Pathologica
https://www.readbyqxmd.com/read/28182081/cytopathologic-features-of-an-unusual-case-of-multiple-eccrine-spiradenomas-misdiagnosed-as-a-malignant-round-cell-tumor
#19
Bharat Rekhi, Archi Agarwal
A 28-year-old lady presented with multiple swellings in her left shoulder, associated with intermittent pain since last one and a half years. Radiologic imaging revealed multiple, well-defined, subcutaneous lesions in her left supraclavicular region. Fine needle aspiration cytology (FNAC) smears were initially reported as Ewing sarcoma, elsewhere. On review, the smears showed cohesive clusters of round-to-oval cells with scant cytoplasm, which were focally arranged in an acinar-rosetting pattern around hyaline "droplets/bodies," along with few scattered lymphocytes against a background of red blood cells...
January 2017: Journal of Cytology
https://www.readbyqxmd.com/read/28178009/isolated-ectopic-cutaneous-atypical-meningioma-of-the-scalp-another-mimicker-of-primary-adnexal-tumor
#20
Jonathan Konopinski, Victor G Prieto, Doina Ivan, Priyadharsini Nagarajan, Michael T Tetzlaff, Jonathan L Curry, Carlos A Torres-Cabala, Gregory N Fuller, Phyu P Aung
Cutaneous meningiomas are rare tumors most commonly located in the skin and soft tissue of the scalp. They may be congenital (type I), acquired and derived from ectopic arachnoid tissue in the skin (type II), or arise through direct extension from an intracranial meningioma (type III). Despite their well-established documentation in the literature, they may escape recognition when classic features are not present. Herein, we present a case of a cutaneous atypical meningioma (≥4 mitotic figures/10 High Power Fields (HPF)) on the posterior scalp of a 31-year-old man with histologic features mimicking a malignant adnexal tumor...
January 25, 2017: American Journal of Dermatopathology
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