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https://www.readbyqxmd.com/read/29651355/cutaneous-adnexal-cylindroma-of-breast-epithelial-immunoreactivities-for-gata-3-mammaglobin-and-e-cadherin-do-not-equate-to-a-mammary-ductal-neoplasm
#1
A Halima, A M Pannunzio, E M Erstine, J S Ko, W F Bergfeld, R M Malaya, M B Frankel, B C Calhoun, C D Sturgis
Cylindromas are benign epithelial neoplasms derived from cutaneous eccrine adnexal structures. These tumors are most commonly encountered on the head, neck, and scalp of older women. In rare instances, solitary cylindromas may arise at other body sites. In the current case, a cylindroma of the skin of the breast was diagnosed by complete excision. Immunohistochemical studies confirmed the tumor cells to be immunoreactive with cytokeratin AE1/3, cytokeratin 5/6, cytokeratin 7, p63, and SOX10. The neoplastic cells were also noted to be immunoreactive with markers typically expected to be positive in ductal epithelium of the breast including GATA3, mammaglobin, and E-cadherin...
2018: Case Reports in Pathology
https://www.readbyqxmd.com/read/29629953/utility-of-ber-ep4-and-moc-31-in-basaloid-skin-tumor-detection
#2
Pavandeep Gill, Christopher Naugler, Marie S Abi Daoud
Ber-EP4 has been the traditional immunostain used for the detection of basaloid skin tumors. Recently, MOC-31 has shown be superior to Ber-EP4 in the detection of basosquamous basal cell carcinoma (BCC) and many centers are now using both Ber-EP4 and MOC-31 antibodies together to detect these lesions. The objective of this study was to compare the utility of using both Ber-EP4 and MOC-31 immunostains in the detection of basaloid skin tumors and to better characterize the previously unknown staining properties of MOC-31 in cutaneous lesions...
April 7, 2018: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/29624700/sarcomatoid-pilomatrix-carcinoma
#3
Angel Fernandez-Flores, David S Cassarino
Pilomatrical (pilomatrix) carcinoma is a rare cutaneous adnexal tumor with matrical differentiation and recurrent and metastatic potential. Sarcomatoid pilomatrix carcinoma is a rare variant which shows a sarcomatoid component intermingling with the epithelial one. There are only four cases previously published. We present an additional case on the hand of a 78 year-old man which appeared as a 6 mm hyperkeratotic ─focally ulcerated─ plaque. A shave biopsy demonstrated a dermal infiltrative neoplasm, composed of markedly atypical-appearing basaloid cells with focal necrotic/ghost cells, as well as an intimately associated population of atypical oval to spindle-shaped cells...
April 6, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29622469/-microcystic-adnexal-carcinoma-a-case-report
#4
Bastien Jean-Jacques, Jean-Jacques Michels, Alexis Veyssiere, Dima Haidar
We report a case of microcystic adnexal carcinoma in a 80-year-old woman. This is a rare malignant adnexal cutaneous tumor with glandular and follicular differentiation, rare, often asymptomatic, with late diagnosis and slow growth, locally aggressive and rarely metastatic. The distinction with other benign and malignant skin tumors is difficult.
April 2, 2018: Annales de Pathologie
https://www.readbyqxmd.com/read/29620585/ovarian-sertoli-leydig-cell-tumor-with-heterologous-hepatocytes-and-a-hepatocellular-carcinomatous-element
#5
Sohei Yamamoto, Yu Sakai
Sertoli-Leydig cell tumors are a group of tumors composed of variable proportions of Sertoli cells, Leydig cells, and sometimes heterologous elements. We describe the case of a 68-yr-old woman who presented with abdominal distention. A computed tomographic scan revealed a large right adnexal mass without evidence of intrahepatic tumors, and a complete cytoreductive surgery was performed. Pathologic examination revealed a moderately differentiated Sertoli-Leydig cell tumor with various heterologous elements, including gastrointestinal-type glands, insular carcinoid, and aggregations of hepatocytes without significant cytologic atypia...
April 3, 2018: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/29607824/lymphoid-proliferation-in-eyelid-a-primary-follicular-lymphoma-case
#6
Deivy Cruzado-Sánchez, Walter Andree Tellez, Solon Serpa-Frias, Grisnery Maquera
Ocular adnexal lymphoma (OAL) constitutes 8% of all extranodal lymphomas, being rare in the eyelids (5-20%). The objective was to report a case of eyelid follicular lymphoma in a young adult woman. A 35-year-old female with swelling in left lower eyelid with development for 2 months. The visual acuity was 20/20 in both eyes, the tumor mass was 3 cm wide and 1.5 cm long. The contrast-enhanced computed tomography showed a soft-tissue injury in the left lower eyelid but had no signs of local spread according to description...
January 2018: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/29607000/basaloid-follicular-hamartoma-a-case-report-and-a-novel-cosmetic-treatment
#7
Kelly Segars, Hassie Cooper, Daniel J Hogan, Richard Miller, Michael Heaphy, James Spencer
Introduction: Basaloid follicular hamartoma (BFH) is a rare, benign neoplasm of the hair follicle, characterized by multiple brown papules involving the face, scalp, and trunk. It is described by multiple clinical forms, and can present as localized or generalized. Diagnosis is made histologically via biopsy, which is important in order to distinguish BFH from basal cell carcinoma (BCC) or other malignant epithelial neoplasms. Correct diagnosis allows for the avoidance of unnecessary surgeries to remove benign lesions...
March 2018: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/29588264/prognostic-effect-of-isolated-paraaortic-nodal-spread-in-endometrial-cancer
#8
Osman Türkmen, Derman Başaran, Alper Karalok, Günsu Cömert Kimyon, Tolga Taşçı, Işın Üreyen, Gökhan Tulunay, Taner Turan
OBJECTIVE: To evaluate the prognostic effect of isolated paraaortic lymph node metastasis in endometrial cancer (EC). MATERIALS AND METHODS: This retrospective study included patients with FIGO 2009 stage IIIC2 disease due to isolated paraaortic lymph node metastasis (LNM). Patients with sarcomatous histology, synchronous gynecologic cancers and patients with concurrent pelvic lymph node metastases or patients that have intraabdominal tumor spread were excluded...
March 28, 2018: Journal of the Turkish German Gynecological Association
https://www.readbyqxmd.com/read/29567896/syringocystadenoma-papilliferum-and-trichoblastoma-arising-in-the-nevus-sebaceous
#9
Feifei Wang, Yatong Wu, Zhancai Zheng, Yanping Bai
Nevus sebaceous (NS) is a clinically common benign tumor and has a high potential to develop into a great diversity of neoplasms of epidermal and adnexal origins. However, it is a rare phenomenon of the coexistence in a single NS with two or more skin tumors. We report a case of a 58-year-old woman with two kinds of neoplastic proliferation including syringocystadenoma papilliferum and trichoblastoma arising in NS on the scalp.
January 2018: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29538195/one-stage-surgery-for-removal-of-intravascular-leiomyomatosis-extending-to-right-ventricle
#10
Ching-Shu Chiang, Po-Lin Chen, Tzu-Ting Kuo, I-Ming Chen, Nai-Yuan Wu, Hsiao-Huang Chang
RATIONALE: Intravascular leiomyomatosis (IVL) is a rare nonmalignant tumor that can be fatal if untreated. PATIENT CONCERNS: A 49-year-old nulliparous Asian woman who underwent hysterectomy and left salpingo-oophorectomy for multiple uterine leiomyomas 18 months prior presented complaining of intermittent palpitation and chest tightness for approximately 1 month. Echocardiography revealed a large mobile tumor mass extending from the inferior vena cava (IVC) to the right atrium that partially obstructed IVC flow and tricuspid inflow...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29533280/polymorphous-sweat-gland-carcinoma-an-immunohistochemical-and-molecular-study
#11
Shira Ronen, Irene Aguilera-Barrantes, Tamara Giorgadze, Petr Šteiner, Petr Grossmann, Saul Suster
Polymorphous sweat gland carcinoma is an uncommon low-grade malignant adnexal tumor with a marked predilection for the distal extremities. Histologically, the lesions are characterized by a cellular proliferation showing a combination of growth patterns, including trabecular, solid, tubular, cribriform, or adenoid cystic and pseudopapillary. The immunohistochemical and molecular profile of these tumors has not yet been properly addressed. We have studied 3 cases of polymorphous sweat gland carcinoma using a broad panel of immunohistochemical markers including cytokeratin AE1/AE3, CK5/6, MOC31, p40, p63, p16, chromogranin, synaptophysin, CD56, MIB-1, estrogen receptor, progesterone receptor, androgen receptor, BER-EP4, smooth muscle actin, epithelial membrane antigen, carcinoembryonic antigen, CD117, S100 protein, HBME-1, DOG1, vimentin, and mammaglobin...
March 6, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29523662/a-novel-prkar1b-braf-fusion-in-gastrointestinal-stromal-tumor-guides-adjuvant-treatment-decision-making-during-pregnancy
#12
Lindsey M Charo, Adam M Burgoyne, Paul T Fanta, Hitendra Patel, Juliann Chmielecki, Jason K Sicklick, Michael T McHale
Gastrointestinal stromal tumors (GISTs) are rare in pregnancy, with only 11 reported cases. Adjuvant imatinib therapy, which targets the most common driver mutations in GIST ( KIT and PDGFRA) , is recommended for patients with high-risk GIST, but it has known teratogenicity in the first trimester. A 34-year-old G3P2 woman underwent exploratory laparotomy at 16 weeks' gestation for a presumed adnexal mass. Surgical findings included normal adnexa and a 14-cm solid small bowel mass. The mass was resected en bloc with a segment of jejunum followed by a primary anastomosis...
March 2018: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/29518640/the-prevalence-of-occult-endometrial-cancer-in-women-undergoing-hysterectomy-for-benign-indications
#13
Lavanya H Palavalli Parsons, Rebecca Pedersen, Debra L Richardson, Kimberly A Kho
OBJECTIVE: To estimate the frequency of occult endometrial cancer in women undergoing hysterectomy for benign indications. STUDY DESIGN: We performed a retrospective review of all patients undergoing hysterectomies for benign indications at our institution from 2006 to 2014. A departmental database was used to identify all hysterectomies performed, and institutional tumor registry was used to identify cases of endometrial carcinoma. Occult carcinomas were defined as cases with no suspicion preoperatively and histopathologic diagnosis of endometrial cancer postoperatively...
February 21, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29517680/an-ovarian-leydig-cell-tumor-of-ultrasound-negative-in-a-postmenopausal-woman-with-hirsutism-and-hyperandrogenism-a-case-report
#14
Min Chen, Weibin Zhou, Zhe Zhang, Yuting Zou, Chengjiang Li
RATIONALE: The incidence of severe hyperandrogenism associated with masculinity in women is very low. While rare and difficult to diagnose, androgen secreting tumors should be suspected in women with hyperandrogenism and hirsutism, especially in the postmenopausal population. Herein we present one case of ovarian Leydig cell tumor (LCT) with markedly elevated serum testosterone levels and frank hirsutism. PATIENT CONCERNS: A 60-year-old woman, presented with increased hair growth and androgenic alopecia and the hormonal laboratory examination showed that she had elevated serum testosterone level and normal dehydroepiandrosterone sulfate (DHEAS), androstenedione, 17- hydroxyprogesterone, cortisol and thyroid stimulating hormone (TSH)...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29494347/apocrine-axillary-adenocarcinoma-an-aggressive-adnexal-tumor-in-middle-age-individuals
#15
Stanislav N Tolkachjov, Jerry D Brewer, Alina G Bridges
No abstract text is available yet for this article.
November 22, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29484084/radiological-findings-of-two-neoplasms-with-perivascular-epithelioid-cell-differentiation
#16
Timothy Diestelkamp, Zachary Mikes, Robin Wilson-Smith, Pauline Germaine
Perivascular epithelioid cell tumors (PEComas) constitute a rare subset of mesenchymal neoplasms classified by the World Health Organization in 2002. We present two cases of PEComas; the first is a cervical PEComa in a 35-year-old woman with no known past medical history who presented with a palpable pelvic mass; the second is an adnexal PEComa in a 39-year-old woman with a history of colitis who presented with abdominal pain and diarrhea. The rarity of these tumors has led to little information about imaging characteristics which we hope these two cases will help expand...
December 2017: Radiology Case Reports
https://www.readbyqxmd.com/read/29484014/once-in-a-blue-moon-%C3%A2-rare-adnexal-tumor-from-the-clinical-and-videodermoscopical-aspects-to-the-mohs-surgery-and-the-histological-diagnosis
#17
Miriam Rovesti, Francesca Satolli, Roberto Ricci, Roberta Manuguerra, Alfredo Zucchi, Marco Gandolfi, Serena Gianfaldoni, Feliciani Claudio, Uwe Wollina, Georgi Tchernev, Torello Lotti
The adnexal tumours are a very heterogeneous group of lesions, more and more studied in the literature. The squamoid eccrine ductal carcinoma (SEDC) is a rare malignant variant that combines ductal structures with squamous differentiation. We report a case of dermoscopic and histological diagnosis of SEDC, treated with Mohs Surgery and with no recurrence of a tumour after 12 months of follow up.
January 25, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29480762/indeterminate-adnexal-cysts-at-us-prevalence-and-characteristics-of-ovarian-cancer
#18
Elizabeth A Sadowski, Viktoriya Paroder, Krupa Patel-Lippmann, Jessica B Robbins, Lisa Barroilhet, Elizabeth Maddox, Timothy McMahon, Emmanuel Sampene, Ashish P Wasnik, Alexander D Blaty, Katherine E Maturen
Purpose To assess the prevalence of indeterminate adnexal cysts in women presenting to academic medical centers for pelvic ultrasonography (US), determine the incidence of malignancy, and identify cyst and patient characteristics that are predictive of malignancy. Materials and Methods A multicenter study of US-detected adnexal cysts with appropriate follow-up (surgical pathologic examination, imaging and/or clinical examination) was conducted from January 2008 to June 2012. Indeterminate cysts were classified as category 1 (typical benign appearing cysts >5 cm) or category 2 (cysts with avascular solid components) on the basis of a combination of definitions in the existing literature...
February 26, 2018: Radiology
https://www.readbyqxmd.com/read/29477759/unusual-cystic-lesion-of-the-eyebrow-a-case-report-of-malignant-chondroid-syringoma
#19
J Chauvel-Picard, A Pierrefeu, O Harou, P Breton, N Sigaux
INTRODUCTION: Malignant chondroid syringomas, also known as cutaneous malignant mixed tumors, are rare neoplasms that most frequently occur on the torso or extremities of women. Here we present an illustrated case of a facial malignant chondroid syringoma. MATERIALS AND METHODS: A 32-year-old female patient with no notable medical history presented with an approximately 1cm-wide, painless, palpably-mobile subcutaneous nodule, suggestive of a sebaceous cyst, just above the middle third of the right eyebrow...
February 22, 2018: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29475925/normal-size-ovary-carcinoma-syndrome-with-inguinal-ovarian-cancer-lymph-node-metastases-a-case-report-and-literature-review
#20
Nicolae Bacalbasa, Irina Balescu, Cristian Balalau, Olivia Ionescu, Claudia Stoica
Inguinal lymph node mass as the first sign in patients with ovarian cancer represents a rare situation, with only few cases being reported so far. We present the case of a 46-year-old patient who presented for the apparition of bilateral inguinal tumoral masses in the absence of any other pathological signs. The biopsy revealed the presence of an adenocarcinoma with probable genital origin; however, neither the gynaecological examination nor the computed tomography demonstrated the presence of any suspect lesion...
March 2018: In Vivo
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