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Adnexal tumor

Sidsel Arnspang Pedersen, Sigrun Alba Johannesdottir Schmidt, Lisbet Rosenkrantz Hölmich, Søren Friis, Anton Pottegård, David Gaist
BACKGROUND: Hydrochlorothiazide use has been associated with markedly increased risk of squamous cell carcinoma. No previous studies have investigated the association between hydrochlorothiazide use and the risk of Merkel cell carcinoma (MCC) and malignant adnexal skin tumors (MAST). OBJECTIVE: To examine the association between hydrochlorothiazide use and the risk of MCC and MAST. METHODS: Using Danish nationwide health registries, we identified all patients with incident MCC or MAST during 2004-2015 and matched cases individually to cancer-free population controls by risk set sampling...
June 15, 2018: Journal of the American Academy of Dermatology
Chung-Yuan Lee, Yeh Giin Ngo, Meng-Chih Lee, Yu-Che Ou, Chin-Jung Wang
No abstract text is available yet for this article.
June 13, 2018: Journal of Minimally Invasive Gynecology
Marki E Klapperich, Brittany A Buhalog, Molly A Hinshaw
A male in his twenties presented with a tender finger nodule that had been present for 3 months. Histopathological examination revealed a dermis with nodules of necrotic, athypical epithelaia cells with high nuclear to cytoplasmic ratios. Glandular formation was present with lumens lined by columnar epithelium, consistent with digital papillary adenocarcinoma. Digital papilary adenocarcinoma is a rare malignant adnexal tumor arising from sweat glands and requires further work-up.
April 15, 2018: Dermatology Online Journal
Raoudha Doghri, Salma Chaabouni, Yoldez Houcine, Lamia Charfi, Nadia Boujelbene, Maha Driss, Karima Mrad
The aim of the study was to investigate whether the tumor free distance (TFD), which is the distance in millimeters between the deepest point of invasion and the serosal surface, and absolute depth of invasion (DMI), the distance in millimeters between the endomyometrial junction and the deepest point of myometrial invasion, are useful in surgical staging and in predicting prognosis. The present study retrospectively analyzed 62 cases of endometrial carcinoma with complete surgical staging, carried out over a 4 and half-year period (January 2003 to June 2007)...
July 2018: Molecular and Clinical Oncology
Stephanie Ding, Oded Sagiv, Yunxia Guo, Thomas J Kandl, Sudip D Thakar, Bita Esmaeli
PURPOSE: To evaluate the frequency and nature of changes in T category when eyelid carcinomas are staged using the criteria in the 8th edition instead of the 7th edition of the American Joint Committee on Cancer staging manual. METHODS: Following Institutional Review Board approval, a retrospective review was conducted for all consecutive patients with the diagnosis of eyelid carcinoma treated by the senior author from January 2012 through December 2016. After a review of the clinical and pathologic data, each patient's disease was staged using both the 7th-edition and 8th-edition American Joint Committee on Cancer criteria for eyelid carcinomas...
June 5, 2018: Ophthalmic Plastic and Reconstructive Surgery
Angelo Cassisa, Francesco Colpani, Rosa Rinaldi, Luca Cima
Primary cutaneous follicle center lymphoma is the most frequent cutaneous B-cell lymphoma despite the fact that is an uncommon disease. Mild biological behavior and good prognosis characterized this neoplasm with a low aggressiveness compared with classic nodal follicular lymphoma (FL). Rare histological variants have been described. We present the case of a 72-year-old man who underwent surgery for a cutaneous nodule on his left scapula. The biopsy showed a dermal clear cell proliferation arranged in a nodular and diffuse pattern...
May 30, 2018: American Journal of Dermatopathology
Nabil Abdalla, Robert Piorkowski, Michal Bachanek, Pawel Stanirowski, Krzysztof Cendrowski, Wlodzimierz Sawicki
Aim: This study compared the diagnostic performance of the Risk of Ovarian Malignancy Algorithm (ROMA) and HE4 and CA125 for the presurgical differentiation of adnexal tumors. Material and Methods: This prospective study included 302 patients admitted for surgical treatment due to adnexal tumors. The ROMA was calculated depending on CA125, HE4, and menopausal status. Results: Fifty patients were diagnosed with malignant disease. In the differentiation of malignant from nonmalignant adnexal tumors, the area under curve (AUC) was higher for ROMA and HE4 than that for CA125 in both the premenopausal and postmenopausal subgroups...
2018: Disease Markers
Tolutope Oyasiji, Wei Tan, John Kane, Joseph Skitzki, Valerie Francescutti, Kilian Salerno, Nikhil I Khushalani
BACKGROUND: Malignant adnexal tumors of the skin (MATS) are rare. We aimed to measure the survival of patients with MATS and identify predictors of improved survival. METHODS: A retrospective review of MATS treated at our institution from 1990 to 2012. RESULTS: There were 50 patients within the time period. Median age was 59.5 years (range 22-95); primary site was the head and neck (52%); most common histologic subtypes were skin appendage carcinoma (20%) and eccrine adenocarcinoma (20%); and the vast majority were T1 (44%)...
May 30, 2018: World Journal of Surgical Oncology
Rattapon Amampai, Prapaporn Suprasert
Objective: To determine the percentage of rising serum cancer antigen (CA-125) in singleton pregnant women whose ultrasonographical findings were normal. Methods: Singleton pregnant women who received antenatal care at our institute with a normal ultrasonographical examination in their first and/or second trimester were invited to participate in blood testing for CA-125. The conditions that might affect the CA-125 level were excluded. The normal level of CA-125 was defined as ≤35 U/ml...
2018: Obstetrics and Gynecology International
Alejandra Tomás-Velázquez, Pedro Redondo
Importance: Forehead reconstruction after Mohs surgery has become a challenge for dermatology surgeons, and achieving an excellent cosmetic and functional result is imperative in this location. Objective: To highlight the utility of a frontalis myocutaneous transposition flap (FMTF) for forehead reconstruction after Mohs surgery. Design, Setting, and Participants: Surgical technique case series including 12 patients with large forehead defects recruited between January 2010 and June 2017 at the Dermatology Department of the University Clinic of Navarra, Spain...
May 16, 2018: JAMA Dermatology
Timothy VandenBoom, Victor L Quan, Bin Zhang, Erin M Garfield, Betty Y Kong, Maria C Isales, Elnaz Panah, Catherine Igartua, Timothy Taxter, Nike Beaubier, Kevin White, Pedram Gerami
Recent molecular studies of spitzoid neoplasms have identified mutually exclusive kinase fusions involving ROS1, ALK, RET, BRAF, NTRK1, MET, and NTRK3 as early initiating genomic events. Pigmented spindle cell nevus (PSCN) of Reed is a morphologic variant of Spitz and may be very diagnostically challenging, having histologic features concerning for melanoma. Their occurrence in younger patients, lack of association to sun exposure, and rapid early growth phase similar to Spitz nevi suggest fusions may also play a significant role in these lesions...
May 22, 2018: American Journal of Surgical Pathology
Aida Valencia-Guerrero, Karen Dresser, Kristine M Cornejo
The distinction between primary adnexal carcinoma (PAC) from metastatic breast carcinoma (BrCa) to skin and squamous cell carcinoma (SCC), particularly those with ductal differentiation (SCCDD), can be quite challenging, despite adequate history. The aim of the study was to determine the utility of an immunohistochemistry (IHC) panel to differentiate these entities and apply them to ambiguous tumors. Twenty-seven PAC, 7 metastatic BrCa, 28 SCC, and 16 ambiguous cases (SCCDD vs. PAC, n = 13 and metastatic BrCa vs...
June 2018: American Journal of Dermatopathology
Kanae Fukutsu, Satoru Kase, Kan Ishijima, Rumiko Kinoshita, Susumu Ishida
BACKGROUND: To examine the clinical features of radiation cataract in patients with ocular adnexal mucosa-associated lymphoid tissue (MALT) lymphoma. METHODS: Twenty-one patients with 26 eyes diagnosed with ocular adnexal MALT lymphoma (26 eyes), who were treated in Hokkaido University Hospital, were retrospectively reviewed based on medical records. RESULTS: Out of the 21 patients, 16 patients (21 eyes) received radiation therapy (RT) with a total dose of 30 Gy...
May 16, 2018: Radiation Oncology
Sefa Kurt, Hüseyin Aytuğ Avşar, Ömer Erbil Doğan, Hasan Bahadır Saatli, Uğur Saygılı
OBJECTIVE: Examining the cases of mature cystic teratoma (MCT) that are diagnosed and treated in our clinic regarding their association with fertility; and detecting the rate of malignant degeneration and the types of malignancies. MATERIAL AND METHODS: Patients, operated due to adnexal mass between April 2012 and August 2017 and diagnosed with MCT, were retrospectively examined. Mean age of the 80 cases, which met the criteria, was 30.60±10.5. 9 were suffering from infertility, according to hospital records...
May 14, 2018: Journal of the Turkish German Gynecological Association
Patricia Benavent Correro, Marta Sáenz Valls, Ana García Cano, Lucía Jiménez Mendiguchia, Esther Moreno Moreno, Manuel Luque-Ramírez
BACKGROUND: Virilism is a female disorder in which secondary male sexual characteristics develop, caused by an excessive adrenal or ovarian androgen secretion. CASE PRESENTATION: Here, we report an unusual case of an ovarian steroid cell tumor, not otherwise specified (NOS), in a 68-year-old female who presented with androgenic alopecia, clitoromegaly and an increased muscle mass. Laboratory investigations revealed both ovarian and adrenal hyperandrogenism with an elevation of androgen precursors mimicking congenital adrenal hyperplasia...
May 12, 2018: Diagnosis
Dipankar Das, Harsha Bhattacharjee, Apurba Deka, Panna Deka, Samir Serasiya, Kasturi Bhattacharjee, Jayanta Kumar Das, Ganesh Chandra Kuri, Eknath Pawar, Rushil Kumar Saxena
Background & objectives: Ocular and adnexal tumours are important causes of morbidity in India and globally. Immunohistochemistry (IHC) is a vital molecular pathology tool, which helps to diagnose a tumour with more accuracy. The present study was undertaken to document the profile of ocular and adnexal tumour with IHC at a tertiary eye care center in Northeast India. Methods: This was a prospective and laboratory-based study. Histopathological and IHC study of the ocular and adnexal tumour was carried out from 2012 to 2014...
January 2018: Indian Journal of Medical Research
Shira Ronen, Alejandro A Gru, Mary M Noland, David M Rowe, Mark R Wick
Sclerosing squamous cell carcinoma (SCC), also known as "desmoplastic" SCC, is a rare subtype of cutaneous malignancy. This variant is clinically significant because it is associated with an increased risk of local recurrence and metastasis. We herein present 16 examples of sclerotic SCC of the skin in 8 men and 3 women, with a median age of 66 years. The most common site of origin for this tumor is the skin of the head and neck, including the scalp (5 tumors in 2 different patients), forehead (3 cases), nasal ala (2 cases), neck (2 cases in the same patient), ear (2 cases), cheek (1 case), and chest (1 case)...
May 8, 2018: American Journal of Dermatopathology
Tianjiao Chen, Jianchu Li, Xiao Yang, Huifang Huang, Sheng Cai
RATIONALE: Ultrasound features of lobulated ovaries are rarely described in the literature. Here, we report a case of pathologically proven lobulated ovaries. PATIENT CONCERNS: A 22-year-old female with irregular menstrual cycles for 9 years came to our hospital because of endless menstruation and anemia for 1 month. DIAGNOSES: Ultrasound and computed tomography revealed pelvic masses. But diagnosing or excluding neoplasms based on imaging findings was difficult...
May 2018: Medicine (Baltimore)
Erdogan Nohuz
BACKGROUND: The IOTA (International Ovarian Tumour Analysis) group has developed the ADNEX (Assessment of Different NEoplasias in the adneXa) model to predict the risk that an ovarian mass is benign, borderline or malignant. This study aimed to test reliability of these risks prediction models to improve the performance of pelvic ultrasound and discriminate between benign and malignant cysts. MATERIAL AND METHODS: Postmenopausal women with an adnexal mass (including ovarian, para-ovarian and tubal) and who underwent a standardized ultrasound examination before surgery were included...
April 27, 2018: Journal of Gynecology Obstetrics and Human Reproduction
Jennifer N Stall, Robert H Young
Sixteen adult granulosa cell tumors which had conspicuous zones of cells with pale cytoplasm imparting a resemblance to thecoma are reported. The neoplasms occurred in patients from 38 to 86 yr of age, the majority being over 55 yr of age. Ten tumors were incidental findings, the remainder being associated with symptoms or signs related to an adnexal mass. All the tumors were unilateral, typically small, usually under 5 cm, with only 3 being larger. With 1 exception they were uniformly solid and were typically entirely or focally yellow on sectioning...
April 27, 2018: International Journal of Gynecological Pathology
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