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Adnexal tumor

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https://www.readbyqxmd.com/read/28323779/gata3-and-myb-expression-in-cutaneous-adnexal-neoplasms
#1
Joana Pardal, Uma Sundram, M Angelica Selim, Mai P Hoang
Knowledge of staining pattern of certain immunostains might be useful in the classification of cutaneous adnexal tumors that can have clinical importance. We studied GATA3 and MYB expression in archival materials of 220 adnexal tumors comprised of sebaceous carcinomas, follicular tumors, apocrine carcinoma, predominantly apocrine tumors, predominantly eccrine tumors, and others including adenoid cystic carcinomas. Nuclear GATA3 expression was seen in 70% (153/220) of cases, including sebaceous carcinoma (93%), apocrine carcinoma (93%), follicular neoplasms (100%), and predominantly apocrine neoplasms (69%), yet only 38% of predominantly eccrine neoplasms...
April 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28315929/adnexal-masses-associated-with-peritoneal-involvement-diagnosis-with-ct-and-mri
#2
REVIEW
Audrey Ognong-Boulemo, Anthony Dohan, Christine Hoeffel, Agatha Stanek, François Golfier, Olivier Glehen, Pierre-Jean Valette, Pascal Rousset
Given the unique intra-peritoneal anatomic location of the adnexa, tubo-ovarian diseases can commonly spread into the peritoneal cavity. Peritoneal seeding may occur in a spectrum of adnexal conditions including infectious diseases, endometriosis, and benign or malignant primary or secondary ovarian tumors. CT is usually the imaging modality on which the concomitant involvement of the peritoneum and the ovary is depicted. The first diagnosis to be considered by the radiologist is generally peritoneal carcinomatosis from ovarian cancer but other conditions cited above have also to be borne in mind and may be suggested on the basis of careful assessment of CT findings or on further MR findings...
March 18, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28300863/an-aggressive-microcystic-adnexal-carcinoma-infiltrating-the-sternum
#3
Laura F Sandoval, Howard Steinman
Microcystic adnexal carcinoma is a rare cutaneous tumor that is often misdiagnosed and has the potential to be aggressive. Mohs surgery is the treatment of choice to prevent recurrences. We present a case of a large recurrent microcystic adnexal carcinoma on the sternum, initially diagnosed as a basal cell carcinoma. This tumor infiltrated the muscle and bone and was unresectable with Mohs surgery. <p><em>J Drugs Dermatol. 2017;16(2):180-181.</em></p>.
February 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28299221/endocrine-mucin-producing-sweat-gland-carcinoma-a-histological-challenge
#4
Mary Anne Brett, Samih Salama, Gabriella Gohla, Salem Alowami
Endocrine mucin-producing sweat gland carcinoma (EMPSGC) is a rare adnexal tumor of the skin with low-grade cytological features and neuroendocrine differentiation. It has a predilection for the skin of the eyelid, but has also been reported in the face and rarely extra-facial locations. The tumor is seen more frequently in women and on average affects the elderly. It is histologically and immunohistochemically analogous to solid papillary carcinoma of the breast/endocrine ductal carcinoma in situ with a nodular, solid, papillary, and/or cribriforming architecture, neuroendocrine differentiation, and mucin production...
2017: Case Reports in Pathology
https://www.readbyqxmd.com/read/28290977/actinomyces-related-tubo-ovarian-abscess-in-a-poorly-controlled-type-ii-diabetic-with-a-copper-intrauterine-device
#5
Ashley L Sawtelle, Nicole P Chappell, Caela R Miller
BACKGROUND: The historic association of Actinomyces israelii infection with intrauterine devices (IUDs) has long been recognized. In recent years, the risk of developing pelvic inflammatory disease with a copper or levonorgestrel IUD has been less than 1% in women who are low risk for sexually transmitted infections. IUD-related pelvic infections secondary to actinomyces have largely vanished from contemporary practice. CASE: A 49-year-old using a copper IUD for contraception with poorly controlled type II diabetes mellitus was admitted for suspected tubo-ovarian abscess on the basis of abdominopelvic pain, leukocytosis, and computed tomography findings...
March 2017: Military Medicine
https://www.readbyqxmd.com/read/28288706/ocular-adnexal-marginal-zone-lymphoma-clinical-presentation-pathogenesis-diagnosis-prognosis-and-treatment
#6
REVIEW
Marianna Sassone, Maurilio Ponzoni, Andrés J M Ferreri
Ocular adnexal marginal zone lymphoma (OAML) represents 1-2% of all non Hodgkin lymphomas. In the last few years many advances in understanding the pathogenesis and the molecular basis involved in its development have been done. Many potential risk factors have been proposed; a dysregulation of immune response in association with a chronic antigenic stimulation, have been hypothesized as possible pathogenic mechanism. In particular, Chlamydia psittaci infection has been related to OAML arising, and eradicating antibiotic therapy has been addressed as a safe and cost-effective approach...
March 2017: Best Practice & Research. Clinical Haematology
https://www.readbyqxmd.com/read/28286683/low-grade-appendiceal-mucinous-neoplasm-presenting-as-an-adnexal-mass
#7
P Panagopoulos, T Tsokaki, E Misiakos, V Domi, C Christodoulaki, D Sioutis, N Papantoniou
Appendiceal tumors are rare, late diagnosed neoplasms that may not be differentiated from adnexal masses even by advanced imaging methods and other diagnostic procedures. They may be asymptomatic and remain undiagnosed until surgery. We report a case of an 80-year-old postmenopausal woman presenting with a pelvic mass and a history of weight loss. The patient underwent laparotomy which revealed an appendiceal mucocele, for which she received a full oncological procedure. The histology report showed a low-grade appendiceal mucinous neoplasm, and the patient underwent six cycles of chemotherapy...
2017: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28284233/retrospective-study-of-rare-cutaneous-malignant-adnexal-tumors-of-the-head-and-neck-in-a-tertiary-care-cancer-hospital-a-case-series
#8
Omer Waqas, Muhammad Faisal, Irfan Haider, Awais Amjad, Arif Jamshed, Raza Hussain
BACKGROUND: Adnexal tumors of the skin are a large and diverse group of benign and malignant neoplasms, which exhibit morphological differentiation toward one of the different types of adnexal epithelium present in normal skin and they pose a diagnostic challenge. The purpose of this study is to share our experience with these rare but aggressive tumors at a tertiary care cancer hospital in a developing country. A retrospective review of 11 patients diagnosed with rare adnexal tumors and their variants from January 2005 to December 2014, treated either surgically or non-surgically, was performed to describe the clinicopathological characteristics and outcome of the disease...
March 12, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28277338/endometrioid-adenocarcinoma-arising-in-a-paratubal-cyst-a-case-report-and-review-of-the-literature
#9
Catherine Chang, Koji Matsuo, Paulette Mhawech-Fauceglia
A 56-year-old G3P3 postmenopausal woman presented with a 5 month history of abnormal uterine bleeding and pelvic pain. A computed tomographic scan revealed a 5 cm right adnexal cystic mass in addition to a thickened, heterogenous endometrium and leiomyomatous uterus. A total laparascopic hysterectomy and bilateral salpingo-oophorectomy with omental and peritoneal biopsy were performed. Gross examination revealed a 12 week size uterus with small fibroids, normal bilateral atrophic ovaries, and a right paratubal cyst...
March 2017: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/28266033/first-international-consensus-report-on-adnexal-masses-management-recommendations
#10
Phyllis Glanc, Beryl Benacerraf, Tom Bourne, Douglas Brown, Beverly G Coleman, Christopher Crum, Jason Dodge, Deborah Levine, Edward Pavlik, Dirk Timmerman, Frederick R Ueland, Wendy Wolfman, Steven R Goldstein
The First International Consensus Conference on Adnexal Masses was convened to thoroughly examine the state of the science and to formulate recommendations for clinical assessment and management. The panel included representatives of societies in the fields of gynecology, gynecologic oncology, radiology, and pathology and clinicians from Europe, Canada, and the United States. In the United States, there are approximately 9.1 surgeries per malignancy compared to the European International Ovarian Tumor Analysis center trials, with only 2...
March 7, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28225558/cutaneous-adnexal-adenocarcinoma-with-exquisite-sensitivity-to-trastuzumab
#11
Timothy J Brown, David J Sher, Lucien A Nedzi, Randall S Hughes, Muhammad S Beg, Jason Mull, Venetia R Sarode, Saad A Khan
BACKGROUND: Cutaneous adnexal adenocarcinoma is a rare cancer that is occasionally human epidermal growth factor receptor-2 (HER-2)-positive, and demonstrates variable response to HER-2 inhibitors. METHODS: We report a case of adnexal adenocarcinoma of the scalp in a 56-year-old man. He underwent wide local excision with cervical node dissection followed by radiation, but had extensive local recurrence. RESULTS: Pathology demonstrated a poorly differentiated adnexal adenocarcinoma with HER-2 overexpression by immunohistochemistry (IHC) and high HER-2 gene amplification by fluorescence in situ hybridization...
February 22, 2017: Head & Neck
https://www.readbyqxmd.com/read/28217669/single-port-access-laparoscopic-surgery-for-large-adnexal-tumors-initial-51-cases-of-a-single-institute
#12
Bo Ra Cho, Jae Won Han, Tae Hyun Kim, Ae Ra Han, Sung Eun Hur, Sung Ki Lee, Chul Jung Kim
OBJECTIVE: Investigation of initial 51 cases of single port access (SPA) laparoscopic surgery for large adnexal tumors and evaluation of safety and feasibility of the surgical technique. METHODS: We retrospectively reviewed the medical records of the first 51 patients who received SPA laparoscopic surgery for large adnexal tumors greater than 10 cm, from July 2010 to February 2015. RESULTS: SPA adnexal surgeries were successfully completed in 51 patients (100%)...
January 2017: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/28216544/surgery-and-electrochemotherapy-treatment-of-incompletely-excised-mammary-carcinoma-in-two-male-pet-rats-rattus-norvegicus
#13
Andrea Lanza, Michela Pettorali, Alfonso Baldi, Enrico P Spugnini
Two male rats (Rattus norvegicus; 18 and 24 months old), were referred for treatment of large masses located in the axillary area. Following total body radiography and hematological and serum biochemical analysis, the rats were anesthetized, and the masses were surgically removed. Both lesions were diagnosed as mammary carcinoma based on histopathological diagnosis. The tumor beds were treated with two sessions of electrochemotherapy (ECT), two weeks apart. ECT involved cisplatin administration in the tumor bed, followed by a series of eight biphasic electric pulses...
February 18, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28203164/successful-treatment-of-advanced-primary-cutaneous-apocrine-carcinoma-on-the-scrotum-with-systemic-chemotherapy-and-radiotherapy-followed-by-denosumab
#14
Sadanori Furudate, Taku Fujimura, Akira Tsukada, Yota Sato, Takanori Hidaka, Kayo Tanita, Yumi Kambayashi, Takahiro Haga, Akira Hashimoto, Setsuya Aiba
Primary cutaneous apocrine carcinoma (PCAC) is a rare and highly aggressive cutaneous adnexal type of tumor that has a high metastasis rate and a poor prognosis. Although there are several case reports describing the successful treatment of PCAC with chemoradiotherapy or molecular targeting therapy, no standard therapy for the treatment of advanced PCAC has been established yet. Since receptor activator of nuclear factor kappa-B ligand (RANKL) is expressed in cancers of apocrine origin, leading to immunosuppression at the tumor site, we hypothesized that targeting RANKL with denosumab might be useful for the treatment of PCAC...
January 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/28195265/solid-papillary-carcinoma-of-the-nipple-an-in-situ-carcinoma-or-an-expansive-growth-tumor
#15
D Tacchini, L Vassallo, M A G M Butorano, V Mancini, T Megha
Papillary breast lesions are a heterogeneous group of tumors which mainly arise in the central mammary region, ranging from benign to malignant. Among them, solid papillary carcinoma (SPC) represents a very uncommon variant with indolent clinical behavior and excellent prognosis. The categorization of papillary lesions as benign, atypical or malignant is often difficult even for experienced pathologists. Furthermore, for prognostic purposes, to decide whether to consider a lesions as in situ when it is not associated with frank invasive foci of carcinoma may be problematic...
September 2016: Pathologica
https://www.readbyqxmd.com/read/28182081/cytopathologic-features-of-an-unusual-case-of-multiple-eccrine-spiradenomas-misdiagnosed-as-a-malignant-round-cell-tumor
#16
Bharat Rekhi, Archi Agarwal
A 28-year-old lady presented with multiple swellings in her left shoulder, associated with intermittent pain since last one and a half years. Radiologic imaging revealed multiple, well-defined, subcutaneous lesions in her left supraclavicular region. Fine needle aspiration cytology (FNAC) smears were initially reported as Ewing sarcoma, elsewhere. On review, the smears showed cohesive clusters of round-to-oval cells with scant cytoplasm, which were focally arranged in an acinar-rosetting pattern around hyaline "droplets/bodies," along with few scattered lymphocytes against a background of red blood cells...
January 2017: Journal of Cytology
https://www.readbyqxmd.com/read/28178009/isolated-ectopic-cutaneous-atypical-meningioma-of-the-scalp-another-mimicker-of-primary-adnexal-tumor
#17
Jonathan Konopinski, Victor G Prieto, Doina Ivan, Priyadharsini Nagarajan, Michael T Tetzlaff, Jonathan L Curry, Carlos A Torres-Cabala, Gregory N Fuller, Phyu P Aung
Cutaneous meningiomas are rare tumors most commonly located in the skin and soft tissue of the scalp. They may be congenital (type I), acquired and derived from ectopic arachnoid tissue in the skin (type II), or arise through direct extension from an intracranial meningioma (type III). Despite their well-established documentation in the literature, they may escape recognition when classic features are not present. Herein, we present a case of a cutaneous atypical meningioma (≥4 mitotic figures/10 High Power Fields (HPF)) on the posterior scalp of a 31-year-old man with histologic features mimicking a malignant adnexal tumor...
January 25, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28169867/germinotropic-onychocytic-matricoma-a-new-histopathologic-subtype-of-onychocytic-matricoma-in-the-light-of-the-microanatomy-of-the-normal-nail-unit-with-special-reference-to-nail-mesenchyme
#18
Christophe Perrin
Onychocytic matricoma (OCM) is a benign tumor of adnexal keratinocytes in which there is complete cytodifferentiation toward the germinative cells of the nail matrix, the keratogenous zone cells, and cells of the nail plate. Several microscopic variants of OCM were initially recognized; acanthotic type, acanthotic and papillomatous type, keratogenous type, and melanocytic as slight proliferation of dendritic melanocytes within the basaloid cells. This study reports an additional histopathologic variant of OCM...
February 2, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28165350/sebaceous-carcinoma-treated-with-mohs-micrographic-surgery
#19
Kimberly L Brady, Eva A Hurst
BACKGROUND: Sebaceous carcinoma is a rare and potentially aggressive adnexal neoplasm with historic data indicating high rates of recurrence, metastasis, and cancer-specific mortality. OBJECTIVE: To evaluate the incidence of local recurrence, metastasis, disease-specific mortality, and all-cause mortality and to identify work-up approaches. PATIENTS AND METHODS/MATERIALS: Retrospective review of patients with sebaceous carcinoma treated with Mohs micrographic surgery between 2001 and 2013 at one institution...
February 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28137453/ovarian-preservation-from-tumors-and-torsions-in-girls-prospective-diagnostic-study
#20
Z B Stanković, K Sedlecky, D Savić, B J Lukač, I Mažibrada, S Perovic
STUDY OBJECTIVE: To develop a new decision tree system (DTS) for the management of adnexal masses in prepubertal and adolescent girls, aimed to improve the distinction between benign and malignant masses, help preserve affected ovaries during surgery and reduce the rate of surgical management of uncomplicated functional ovarian cysts. DESIGN: A prospective diagnostic study using clinical and ultrasound data collected for all patients under 19 years of age with adnexal masses managed between 2006 and 2015...
January 27, 2017: Journal of Pediatric and Adolescent Gynecology
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