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https://www.readbyqxmd.com/read/28225285/multi-scale-modeling-of-the-effects-of-salt-and-perfume-raw-materials-on-the-rheological-properties-of-commercial-thread-like-micellar-solutions
#1
Xueming Tang, Weizhong Zou, Peter H Koenig, Shawn D McConaughy, Michael R Weaver, David Michael Eike, Michael J Schmidt, Ronald G Larson
We link micellar structures to rheological properties for two surfactant body-wash formulations at various concentrations of salts and perfume raw materials (PRMs) using molecular simulations and micellar-scale modeling as well as traditional surfactant packing arguments. The two body washes, named BW-1EO and BW-3EO, are composed of sodium lauryl ethylene glycol ether sulfate (SLEnS, where n is the average number of ethylene glycol repeat units), cocamidopropyl betaine (CAPB), ACCORD (which is a mixture of six PRMs), and NaCl salt...
February 22, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28222859/determination-of-benzimidazoles-in-meat-samples-by-capillary-zone-electrophoresis-tandem-mass-spectrometry-following-dispersive-liquid-liquid-microextraction
#2
Carmen Tejada-Casado, David Moreno-González, Francisco J Lara, Ana M García-Campaña, Monsalud Del Olmo-Iruela
A novel method based on capillary zone electrophoresis-tandem mass spectrometry has been proposed and validated for the identification and simultaneous quantification of twelve benzimidazoles in meat samples. Electrophoretic separation was carried out using 500mM formic acid (pH 2.2) as background electrolyte and applying a voltage of 25kV at 25°C. In order to improve the sensitivity, stacking mode injection was applied, using as injection solvent a mixture of 30:70 acetonitrile/water at 50mbar for 75s. Sensitivity enhancement factors from 74 to 317 were obtained under these conditions...
February 14, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28221358/ionic-solutions-of-two-dimensional-materials
#3
Patrick L Cullen, Kathleen M Cox, Mohammed K Bin Subhan, Loren Picco, Oliver D Payton, David J Buckley, Thomas S Miller, Stephen A Hodge, Neal T Skipper, Vasiliki Tileli, Christopher A Howard
Strategies for forming liquid dispersions of nanomaterials typically focus on retarding reaggregation, for example via surface modification, as opposed to promoting the thermodynamically driven dissolution common for molecule-sized species. Here we demonstrate the true dissolution of a wide range of important 2D nanomaterials by forming layered material salts that spontaneously dissolve in polar solvents yielding ionic solutions. The benign dissolution advantageously maintains the morphology of the starting material, is stable against reaggregation and can achieve solutions containing exclusively individualized monolayers...
March 2017: Nature Chemistry
https://www.readbyqxmd.com/read/28220917/ditopic-receptors-containing-urea-groups-for-solvent-extraction-of-cu-ii-salts
#4
Israel Carreira-Barral, Marta Mato-Iglesias, Andrés de Blas, Carlos Platas-Iglesias, Peter A Tasker, David Esteban-Gómez
The ditopic receptor L3 [1-(2-((7-(4-(tert-butyl)benzyl)-1,4,7,10-tetraazacyclododecan-1-yl)methyl)phenyl)-3-(3-nitrophenyl)urea] containing a macrocyclic cyclen unit for Cu(ii)-coordination and a urea moiety for anion binding was designed for recognition of metal salts. The X-ray structure of [CuL3(SO4)] shows that the sulfate anion is involved in cooperative binding via coordination to the metal ion and hydrogen-bonding to the urea unit. This behaviour is similar to that observed for the related receptor L1 [1-(2-((bis(pyridin-2-ylmethyl)amino)methyl)phenyl)-3-(3-nitrophenyl)urea], which forms a dimeric [CuL1(μ-SO4)]2 structure in the solid state...
February 21, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28217334/structural-characterization-of-two-tetra-chlorido-zincate-salts-of-4-carb-oxy-1h-imidazol-3-ium-a-salt-hydrate-and-a-co-crystal-salt-hydrate
#5
Sean J Martens, David K Geiger
Imidazole-containing compounds exhibit a myriad of pharmacological activities. Two tetra-chlorido-zincate salts of 4-carb-oxy-1H-imidazol-3-ium, ImHCO2H(+), are reported. Bis(4-carb-oxy-1H-imidazol-3-ium) tetra-chlorido-zincate monohydrate, (C4H5N2O2)2[ZnCl4]·H2O, (I), crystallizes as a monohydrate salt, while bis-(4-carb-oxy-1H-imidazol-3-ium) tetra-chlorido-zincate bis-(1H-imidazol-3-ium-4-carboxyl-ato) monohydrate, (C4H5N2O2)2[ZnCl4]·2C4H4N2O2·H2O, (II), is a co-crystal salt with six residues: two ImHCO2H(+) cations, two formula units of the zwitterionic 1H-imidazol-3-ium-4-carboxyl-ate, ImHCO2, one tetra-chlorido-zincate anion and one water mol-ecule disordered over two sites in a 0...
February 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/28217276/synthesis-and-biological-evaluation-of-benzocyclooctene-based-and-indene-based-anticancer-agents-that-function-as-inhibitors-of-tubulin-polymerization
#6
Christine A Herdman, Tracy E Strecker, Rajendra P Tanpure, Zhi Chen, Alex Winters, Jeni Gerberich, Li Liu, Ernest Hamel, Ralph P Mason, David J Chaplin, Mary Lynn Trawick, Kevin G Pinney
The natural products colchicine and combretastatin A-4 (CA4) have been inspirational for the design and synthesis of structurally related analogues and spin-off compounds as inhibitors of tubulin polymerization. The discovery that a water-soluble phosphate prodrug salt of CA4 (referred to as CA4P) is capable of imparting profound and selective damage to tumor-associated blood vessels paved the way for the development of a new therapeutic approach for cancer treatment utilizing small-molecule inhibitors of tubulin polymerization that also act as vascular disrupting agents (VDAs)...
December 1, 2016: MedChemComm
https://www.readbyqxmd.com/read/28207023/chelated-bis-nhc-complexes-of-saturated-imidazolin-2-ylidene-nhc-ligands-structural-authentication-and-facile-ligand-fragmentation
#7
Michael G Gardiner, David S McGuinness, Catriona R Vanston
The CH2-linked bis(NHC) complexes [{((S)MesIm)2CH2}PdBr2] and [{((S)MesIm)2CH2}Pd(NCMe)2][PF6]2 are reported. These represent the first structurally characterized chelated, saturated bis(NHC) complexes. The complexes are subject to facile ligand fragmentation during their synthesis. Longer (CH2)n-linkers in the imidazolin-2-ylidene-based series of ligands afforded the pendant imidazolinium mono(NHC) complexes [{((S)MesImH)((S)MesIm)(CH2)n}PdBr3] by reaction of the diimidazolinium salts (n = 2, 3) with palladium acetate...
February 16, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28198593/electrochemical-behavior-of-pedot-lignin-in-ionic-liquid-electrolytes-suitable-cathode-electrolyte-system-for-sodium-batteries
#8
Nerea Casado, Matthias Hilder, Cristina Pozo-Gonzalo, Maria Forsyth, David Mecerreyes
Biomass derived polymers, such as lignin, contain redox quinone/hydroquinone redox moieties that can be used to store charge. Composites based on the biopolymer lignin and several conjugated polymers have shown good charge storage properties. However, their performance has been just studied in acidic aqueous media limiting the applications mainly to supercapacitors. Here we show that PEDOT/Lignin biopolymers are electroactive in aprotic ionic liquids and we move a step further by assembling sodium full cell batteries using PEDOT/Lignin as electrode material and ionic liquid electrolytes...
February 15, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28195710/palladium-catalyzed-hydrohalogenation-of-1-6-enynes-hydrogen-halide-salts-and-alkyl-halides-as-convenient-hx-surrogates
#9
David A Petrone, Ivan Franzoni, Juntao Ye, Jose F Rodriguez, Amalia I Poblador-Bahamonde, Mark Lautens
Difficulties associated with the handling H2 and CO in metal-catalyzed processes has led to the development of chemical surrogates to these species. Despite many successful examples using this strategy, the application of convenient hydrogen halide (HX) surrogates in catalysis has lagged behind considerably. We now report the use of ammonium halides as HX surrogates to accomplish a novel Pd-catalyzed hydrohalogenation of enynes. These safe and practical salts avoid many drawbacks associated with traditional HX sources including toxicity and corrosiveness...
February 14, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28193667/whole-genome-sequencing-of-a-large-panel-of-contemporary-neisseria-gonorrhoeae-clinical-isolates-indicates-that-a-wild-type-mtra-gene-is-common-implications-for-inducible-antimicrobial-resistance
#10
Eshaw Vidyaprakash, A Jeanine Abrams, William M Shafer, David L Trees
Previous studies (1) have shown that the expression of the mtrCDE efflux pump operon is inducible at the transcriptional level in gonococci during incubation in sub-lethal concentrations of the nonionic detergent Triton X-100, which along with antibiotics, bile salts, progesterone and antimicrobial peptides, is a substrate of the MtrCDE efflux pump (2).….
February 13, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28192441/cyclic-amp-regulates-postnatal-development-of-neural-and-behavioral-responses-to-nacl-in-rats
#11
Jie Qian, Shobha Mummalaneni, Tam-Hao T Phan, Gerard L Heck, John A DeSimone, David West, Sunila Mahavadi, Deanna Hojati, Karnam S Murthy, Mee-Ra Rhyu, Andrew I Spielman, Mehmet Hakan Özdener, Vijay Lyall
During postnatal development rats demonstrate an age-dependent increase in NaCl chorda tympani (CT) responses and the number of functional apical amiloride-sensitive epithelial Na+ channels (ENaCs) in salt sensing fungiform (FF) taste receptor cells (TRCs). Currently, the intracellular signals that regulate the postnatal development of salt taste have not been identified. We investigated the effect of cAMP, a downstream signal for arginine vasopressin (AVP) action, on the postnatal development of NaCl responses in 19-23 day old rats...
2017: PloS One
https://www.readbyqxmd.com/read/28186725/small-molecules-engage-hot-spots-through-cooperative-binding-to-inhibit-a-tight-protein-protein-interaction
#12
Degang Liu, David Xu, Min Liu, William Eric Knabe, Cai Yuan, Donghui Zhou, Mingdong Huang, Samy O Meroueh
Protein-protein interactions drive every aspect of cell signaling, yet there exist only few small-molecule inhibitors of these interactions. Despite our ability to identify critical residues known as hot spots, little is known about how to effectively engage them to disrupt protein-protein interactions. Here, we take advantage of the ease of preparation and stability of pyrrolinone 1, a small-molecule inhibitor of the tight uPAR•uPA interaction, to synthesize more than 40 derivatives and explore their effect on the protein-protein interaction...
February 10, 2017: Biochemistry
https://www.readbyqxmd.com/read/28179952/nucleophilic-displacement-reactions-of-5-derivatised-nucleosides-in-a-vibration-ball-mill
#13
Olga Eguaogie, Patrick F Conlon, Francesco Ravalico, Jamie S T Sweet, Thomas B Elder, Louis P Conway, Marc E Lennon, David R W Hodgson, Joseph S Vyle
Vibration ball-milling in a zirconia-lined vessel afforded clean and quantitative nucleophilic displacement reactions between 4-methoxybenzylthiolate salts and nucleoside 5'-halides or 5'-tosylates in five to 60 minutes. Under these conditions, commonly-encountered nucleoside cyclisation byproducts (especially of purine nucleosides) were not observed. Liquid-assisted grinding of the same 5'-iodide and 5'-tosylate substrates with potassium selenocyanate in the presence of DMF produced the corresponding 5'-selenocyanates in variable yields over the course of between one and eleven hours thereby avoiding the preparation and use of hygroscopic tetrabutylammonium salts...
2017: Beilstein Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28179257/interplay-between-renal-endothelin-and-purinergic-signaling-systems
#14
Eman Y Gohar, Malgorzata Kasztan, David M Pollock
Alterations in extracellular fluid volume regulation and sodium balance may result in the development and maintenance of salt-dependent hypertension, a major risk factor for cardiovascular disease. Numerous pathways contribute to the regulation of sodium excretion and blood pressure, including endothelin and purinergic signaling. Increasing evidence suggests a link between purinergic receptor activation and endothelin production within the renal collecting duct as a means of promoting natriuresis. A better understanding of the relationship between these two systems, especially in regard to sodium homeostasis, will fill a significant knowledge gap and may provide novel antihypertensive treatment options...
February 8, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28177594/investigation-of-chemosensitivity-during-and-after-an-acute-cold
#15
Robert Pellegrino, Ute Walliczek-Dworschak, Gudrun Winter, David Hull, Thomas Hummel
BACKGROUND: Viral rhinitis (the "common" cold) is a frequent worldwide disease. Olfactory dysfunction is one complication that arises during infection, which in most cases heals up spontaneously upon recovery, whereas in some cases it may persist as a partial or total loss of olfaction. The aim of this prospective study was to investigate the change of other chemosensory systems during a cold. METHODS: Fifty-eight patients (age 18 to 69 years) with an acute cold were compared to a healthy control group (n = 59; age 19 to 63 years)...
February 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28174300/calmodulin-lobes-facilitate-dimerization-and-activation-of-estrogen-receptor-%C3%AE
#16
Zhigang Li, Yonghong Zhang, Andrew C Hedman, James B Ames, David B Sacks
Estrogen receptor alpha (ER-α) is a nuclear hormone receptor that controls selected genes, thereby regulating proliferation and differentiation of target tissues, such as breast. Gene expression controlled by ER-α is modulated by Ca2+ via calmodulin (CaM). Here we present the NMR structure of Ca2+-CaM bound to two molecules of ER-α (residues 287-305). The two lobes of CaM bind to the same site on two separate ER-α molecules (residues 292, 296, 299, 302 and 303), which explains why CaM binds two molecules of ER-α in a 1:2 complex and stabilizes ER-α dimerization...
February 7, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28174298/the-startle-disease-mutation-e103k-impairs-activation-of-human-homomeric-%C3%AE-1-glycine-receptors-by-disrupting-an-intersubunit-salt-bridge-across-the-agonist-binding-site
#17
Fatemah Safar, Elliot Hurdiss, Marios Erotocritou, Timo Greiner, Remigijus Lape, Mark W Irvine, Guangyu Fang, David Jane, Rilei Yu, Marc A Dämgen, Philip C Biggin, Lucia G Sivilotti
Glycine receptors (GlyR) belong to the pentameric ligand gated ion channel (pLGIC) superfamily and mediate fast inhibitory transmission in the vertebrate CNS. Disruption of glycinergic transmission by inherited mutations produces startle disease in man. Many startle mutations are in GlyRs and provide useful clues to the function of the channel domains. E103K is one of few startle mutations found in the extracellular agonist binding site of the channel, in loop A of the principal side of the subunit interface...
February 7, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28169515/fabrication-of-patterned-superhydrophobic-hydrophilic-substrates-by-laser-micromachining-for-small-volume-deposition-and-droplet-based-fluorescence-detection
#18
Kyle John Bachus, Lili Mats, Heeyoon W Choi, Graham T T Gibson, Richard David Oleschuk
The deposition of nanoliter and sub-nanoliter volumes is important in chemical and biochemical droplet-based microfluidic systems. There are several techniques that have been established for the deposition/generation of small volumes including the use of surfaces with patterned differences in wettability. Many such methods require complex and time-consuming lithographic techniques. Here, we present a facile method for the fabrication of superhydrophobic surfaces with patterned hydrophilic regions by laser micromachining...
February 7, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28152197/effect-of-salt-and-ethanol-addition-on-zein-starch-dough-and-bread-quality
#19
Brennan M Smith, Scott R Bean, Gordon Selling, David Sessa, Fadi M Aramouni
Development of viscoelastic doughs from non-wheat proteins allows for a wider range of gluten-free products. Little work has been completed to describe mechanisms of zein functionality in food systems. To identify factors responsible for dough development in zein-starch mixtures and their influence on zein bread quality, a mixture of 20% zein-80% maize starch was mixed with water and various reagents. Salts, NaSCN, NaCl, and Na2 SO4 were evaluated at concentrations from 0 to 2M for their influence on the properties of zein-starch dough systems...
February 2, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28132967/kidney-cadmium-toxicity-diabetes-and-high-blood-pressure-the-perfect-storm
#20
Soisungwan Satarug, David A Vesey, Glenda C Gobe
Cadmium (Cd) is an environmental toxicant of widespread exposure and pervasive toxicity. Absorption, systemic transport and uptake of Cd are mediated by metal transporters that the body uses for acquisition of physiologically-essential elements, notably of iron, zinc and calcium. Currently, human exposure to Cd is known to damage the kidneys, especially the proximal tubular cells that actively reabsorb Cd along with zinc, glucose and amino acids in the glomerular filtrate. Severe kidney damage, glycosuria and proteinuria are known outcomes after high dietary Cd intake (> 200 µg/day)...
2017: Tohoku Journal of Experimental Medicine
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