keyword
MENU ▼
Read by QxMD icon Read
search

Salt DE

keyword
https://www.readbyqxmd.com/read/28634266/30-years-of-the-mineralocorticoid-receptor-the-brain-mineralocorticoid-receptor-a-saga-in-three-episodes
#1
REVIEW
Marian Joëls, E Ronald de Kloet
In 1968, Bruce McEwen discovered that (3)H-corticosterone administered to adrenalectomised rats is retained in neurons of hippocampus rather than those of hypothalamus. This discovery signalled the expansion of endocrinology into the science of higher brain regions. With this in mind, our contribution highlights the saga of the brain mineralocorticoid receptor (MR) in three episodes. First, the precloning era dominated by the conundrum of two types of corticosterone-binding receptors in the brain, which led to the identification of the high-affinity corticosterone receptor as the 'promiscuous' MR cloned in 1987 by Jeff Arriza and Ron Evans in addition to the classical glucocorticoid receptor (GR)...
July 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28624952/endocrine-functions-of-the-renal-interstitium
#2
REVIEW
Armin Kurtz
This review aims to summarize the knowledge about the sensor and endocrine response functions of resident interstitial cells of the kidney. By the production of renin, erythropoietin and arachidonate metabolites (medullipin) subsets of renal interstitial fibroblasts and pericytes in different kidney zones play a central role in salt, blood pressure and oxygen homeostasis of the body. Common to these endocrine functions is that their regulation mainly occurs by (de)recruitment of active cells.
June 17, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/28624744/optimization-of-the-synthesis-of-pd-au-nanoalloys-confined-in-mesoporous-carbonaceous-materials
#3
Alicia Martinez de Yuso, Amandine Maetz, Yassine Oumellal, Claudia Zlotea, Jean-Marc Le Meins, Camelia Matei Ghimbeu
Pd-Au nanoalloys confined in mesoporous carbonaceous materials were synthesized by a rapid one-pot microwave assisted approach. Green polymer resins based on phloroglucinol/glyoxylic acid or glyoxal were co-assembled in the presence of a template and metallic salts followed by microwave treatment between 40 and 80°C and subsequent thermal annealing, allowing simultaneous formation of mesoporous carbonaceous materials with in-situ confined Pd-Au nanoparticles. Several Pd-Au compositions were prepared (PdxAu100-x, where x=90; 80; 70 and 50) and their impact on the alloy structure and particle size/distribution evaluated...
June 10, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28619124/multiplex-tests-to-identify-gastrointestinal-bacteria-viruses-and-parasites-in-people-with-suspected-infectious-gastroenteritis-a-systematic-review-and-economic-analysis
#4
Karoline Freeman, Hema Mistry, Alexander Tsertsvadze, Pam Royle, Noel McCarthy, Sian Taylor-Phillips, Rohini Manuel, James Mason
BACKGROUND: Gastroenteritis is a common, transient disorder usually caused by infection and characterised by the acute onset of diarrhoea. Multiplex gastrointestinal pathogen panel (GPP) tests simultaneously identify common bacterial, viral and parasitic pathogens using molecular testing. By providing test results more rapidly than conventional testing methods, GPP tests might positively influence the treatment and management of patients presenting in hospital or in the community. OBJECTIVE: To systematically review the evidence for GPP tests [xTAG(®) (Luminex, Toronto, ON, Canada), FilmArray (BioFire Diagnostics, Salt Lake City, UT, USA) and Faecal Pathogens B (AusDiagnostics, Beaconsfield, NSW, Australia)] and to develop a de novo economic model to compare the cost-effectiveness of GPP tests with conventional testing in England and Wales...
April 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28613859/donepezil-based-central-acetylcholinesterase-inhibitors-by-means-of-a-bio-oxidizable-prodrug-strategy-design-synthesis-and-in-vitro-biological-evaluation
#5
Ludovic Peauger, Rabah Azzouz, Vincent Gembus, Mihaela-Liliana Tintas, Jana Sopková-de Oliveira Santos, Pierre Bohn, Cyril Papamicaël, Vincent Levacher
With the aim of reducing side effects of acetylcholinesterase inhibitors (AChEIs) during symptomatic treatment of Alzheimer's disease, we report herein a new class of donepezil-based "bio-oxidizable" prodrugs 1 designed to be converted into dual binding site AChEIs 2. While most of indanone-derived N-benzylpyridinium salts 2 revealed to be highly potent dual binding site hAChEIs (IC50 up to 3 nM), outperforming the standard drug donepezil (IC50 = 11 nM), most of the corresponding 1,4-dihydropyridines 1 were found to be inactive...
June 14, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28611124/endothelial-senescence-contributes-to-heart-failure-with-preserved-ejection-fraction-in-an-aging-mouse-model
#6
Andreas B Gevaert, Hadis Shakeri, Arthur J Leloup, Cor E Van Hove, Guido R Y De Meyer, Christiaan J Vrints, Katrien Lemmens, Emeline M Van Craenenbroeck
BACKGROUND: Because of global aging, the prevalence of heart failure with preserved ejection fraction (HFpEF) continues to rise. Although HFpEF pathophysiology remains incompletely understood, endothelial inflammation is stated to play a central role. Cellular senescence is a process of cellular growth arrest linked with aging and inflammation. We used mice with accelerated aging to investigate the role of cellular senescence in HFpEF development. METHODS AND RESULTS: Senescence-accelerated mice (SAM, n=18) and control mice with normal senescence (n=15) were fed normal chow or a high-fat, high-salt diet (WD)...
June 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28604863/dual-gold-photoredox-catalyzed-bis-arylative-cyclization-of-chiral-homopropargyl-sulfonamides-with-diazonium-salts-rapid-access-to-enantioenriched-2-3-dihydropyrroles
#7
Ze-Shu Wang, Tong-De Tan, Cai-Ming Wang, Ding-Qiang Yuan, Te Zhang, Pengfei Zhu, Chunyin Zhu, Jin-Mei Zhou, Long-Wu Ye
A novel dual gold/photoredox-catalyzed bis-arylative cyclization of chiral homopropargyl sulfonamides with diazonium salts has been developed, allowing the facile synthesis of various enantioenriched 2,3-dihydropyrroles in generally moderate to good yields with excellent enantioselectivities under very mild conditions without using any strong oxidants. The reaction is proposed to undergo an Au(I)/Au(III) redox cycle promoted by visible-light photoredox catalysis.
June 12, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28603945/grafting-response-to-excess-boron-and-expression-analysis-of-genes-coding-boron-transporters-in-tomato
#8
Francesco Di Gioia, Alessio Aprile, Erika Sabella, Pietro Santamaria, Alberto Pardossi, Antonio Miceli, Luigi De Bellis, Eliana Nutricati
Boron (B) is essential for plant growth, however its excess in soil and/or in irrigation water can severely compromise plant growth and yield. The goal of this work was to determine whether grafting onto 'Arnold', a commercial interspecific hybrid (Solanum lycopersicum × S. habrochaites) rootstock, which in a previous study was found to be tolerant to salt stress, could improve tomato (S. lycopersicum L. 'Ikram') tolerance to excess B, and whether this effect is associated with an exclusion mechanism. Non-grafted, self-grafted, and grafted plants were hydroponically grown in a greenhouse with B concentration in the nutrient solution of 0...
June 12, 2017: Plant Biology
https://www.readbyqxmd.com/read/28597422/bnaabf2-a-bzip-transcription-factor-from-rapeseed-brassica-napus-l-enhances-drought-and-salt-tolerance-in-transgenic-arabidopsis
#9
Bi-Yan Zhao, Yu-Feng Hu, Juan-Juan Li, Xuan Yao, Ke-de Liu
BACKGROUND: Abiotic stresses such as drought and salt stresses have a negative effect on the growth and productivity of plants. Improvement of stress tolerance through genetic engineering in plants has been reported in intense studies. Transcription factors play vital roles in plant adaptation to stresses by regulating expression of a great deal of target genes. A family of Arabidopsis basic region leucine zipper (bZIP) transcription factors that can recognize and bind to the abscisic acid (ABA)-responsive elements (ABREs) in promoter is named as ABRE binding factors (ABFs)/ABRE binding proteins (AREBs)...
December 2016: Botanical Studies (Taipei, Taiwan)
https://www.readbyqxmd.com/read/28597411/comparative-proteomic-analysis-of-alfalfa-revealed-new-salt-and-drought-stress-related-factors-involved-in-seed-germination
#10
Qiaoli Ma, Junmei Kang, Ruicai Long, Tiejun Zhang, Junbo Xiong, Kun Zhang, Tenghua Wang, Qingchuan Yang, Yan Sun
Salinity and drought are two major environmental factors that limit the growth and yield of many forage crops in semi-arid and arid regions. Alfalfa (Medicago sativa L.) is one of the most important forage crops in many countries. We aim to investigate the molecular mechanisms of alfalfa in response to salt and drought stresses in this study. Physiological and proteomic analyses were applied to examine the Zhongmu NO.3 alfalfa seed germination stage with 200 mM NaCl and 180 g·L(-1) polyethylene glycol (PEG) treatments...
June 9, 2017: Molecular Biology Reports
https://www.readbyqxmd.com/read/28596554/salt-intake-blood-pressure-and-socioeconomic-disparities-among-government-employees-in-sri-lanka-a-cross-sectional-study
#11
Anuji Upekshika Gamage, Rohini De Alwis Seneviratne, Fahad S Hanna
Our study estimated salt intake, examined the association between blood pressure (BP) and salt intake, and explored the socioeconomic variations in salt intake among administrators (government employees). This is a cross-sectional study. We studied 168 randomly selected administrators aged 30-60 years attached to government offices in Colombo, Sri Lanka. Self-administered questionnaire gathered information on socio-demographic, work-related information, lifestyle practices, and medical history. BP, 24-hour urine collection, and anthropometric indices were measured...
June 8, 2017: Journal of Public Health Policy
https://www.readbyqxmd.com/read/28594955/inorganic-salts-and-intracellular-polyphosphate-inclusions-play-a-role-in-the-thermotolerance-of-the-immunobiotic-lactobacillus-rhamnosus-crl-1505
#12
María A Correa Deza, Mariana Grillo-Puertas, Susana Salva, Viviana A Rapisarda, Carla L Gerez, Graciela Font de Valdez
In this work, the thermotolerance of Lactobacillus rhamnosus CRL1505, an immunobiotic strain, was studied as a way to improve the tolerance of the strain to industrial processes involving heat stress. The strain displayed a high intrinsic thermotolerance (55°C, 20 min); however, after 5 min at 60°C in phosphate buffer a two log units decrease in cell viability was observed. Different heat shock media were tested to improve the cell survival. Best results were obtained in the mediumcontaining inorganic salts (KH2PO4, Na2HPO4, MnSO4, and MgSO4) likely as using 10% skim milk...
2017: PloS One
https://www.readbyqxmd.com/read/28594849/high-sodium-diet-converts-renal-proteoglycans-into-pro-inflammatory-mediators-in-rats
#13
Ryanne S Hijmans, Pragyi Shrestha, Kwaku A Sarpong, Saleh Yazdani, Rana El Masri, Wilhelmina H A de Jong, Gerjan Navis, Romain R Vivès, Jacob van den Born
BACKGROUND: High dietary sodium aggravates renal disease by affecting blood pressure and by its recently shown pro-inflammatory and pro-fibrotic effects. Moreover, pro-inflammatory modification of renal heparan sulfate (HS) can induce tissue remodeling. We aim to investigate if high sodium intake in normotensive rats converts renal HS into a pro-inflammatory phenotype, able to bind more sodium and orchestrate inflammation, fibrosis and lymphangiogenesis. METHODS: Wistar rats received a normal diet for 4 weeks, or 8% NaCl diet for 2 or 4 weeks...
2017: PloS One
https://www.readbyqxmd.com/read/28594277/metabolomics-analysis-of-rice-responses-to-salinity-stress-revealed-elevation-of-serotonin-and-gentisic-acid-levels-in-leaves-of-tolerant-varieties
#14
Poulami Gupta, Bratati De
A GC-MS based analytical approach was undertaken in order to understand the metabolomic responses of seedlings of two salt sensitive (Sujala and MTU 7029) and two tolerant varieties (Bhutnath, and Nonabokra) of indica rice (Oryza sativa L.) to NaCl induced stress. The four varieties responded differently to NaCl treatment with respect to the conserved primary metabolites (sugars, polyols, amino acids, organic acids and certain purine derivatives) of the leaf of rice seedlings. However, there were significant differences in salt induced production of chorismic acid derivatives...
June 8, 2017: Plant Signaling & Behavior
https://www.readbyqxmd.com/read/28592561/vaccine-priming-is-restricted-to-draining-lymph-nodes-and-controlled-by-adjuvant-mediated-antigen-uptake
#15
Frank Liang, Gustaf Lindgren, Kerrie J Sandgren, Elizabeth A Thompson, Joseph R Francica, Anja Seubert, Ennio De Gregorio, Susan Barnett, Derek T O'Hagan, Nancy J Sullivan, Richard A Koup, Robert A Seder, Karin Loré
The innate immune mechanisms by which adjuvants enhance the potency and protection of vaccine-induced adaptive immunity are largely unknown. We introduce a model to delineate the steps of how adjuvant-driven innate immune activation leads to priming of vaccine responses using rhesus macaques. Fluorescently labeled HIV-1 envelope glycoprotein (Env) was administered together with the conventional aluminum salt (alum) adjuvant. This was compared to Env given with alum with preabsorbed Toll-like receptor 7 (TLR7) ligand (alum-TLR7) or the emulsion MF59 because they show superiority over alum for qualitatively and quantitatively improved vaccine responses...
June 7, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28591618/exploring-drug-solubility-in-fasted-human-intestinal-fluid-aspirates-impact-of-inter-individual-variability-sampling-site-and-dilution
#16
Mariangeles Pérez de la Cruz-Moreno, Consuelo Montejo, Antonio Aguilar-Ros, Walthère Dewe, Benoît Beck, Jef Stappaerts, Jan Tack, Patrick Augustijns
One of the main factors defining intestinal drug absorption is the solubility of the compound in the gastrointestinal environment. This study reports the solubility of a series of 27 commonly used acidic, neutral and basic drugs in human intestinal fluid samples collected from the duodenum or jejunum of healthy volunteers under fasted state conditions. The interindividual variability as well as the impact of factors such as pH, sampling site and bile salts on the solubility in human intestinal fluids was investigated...
June 4, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28591350/factors-associated-with-chronic-back-pain-in-adults-in-brazil
#17
Deborah Carvalho Malta, Max Moura de Oliveira, Silvânia Suely Caribé de Araújo Andrade, Waleska Teixeira Caiaffa, Maria de Fatima Marinho de Souza, Regina Tomie Ivata Bernal
OBJECTIVE: To identify associations of chronic back pain with sociodemographic characteristics, lifestyles, body mass index, self-reported chronic diseases and health assessment, according to sex. METHODS: We analyzed data from the 2013 National Health Survey, estimated the prevalence and their respective 95% confidence intervals (95%CI) of chronic back pain, according to selected variables and performed adjustment by age and education. RESULTS: 18...
June 1, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/28589715/self-propagated-flaming-synthesis-of-highly-active-layered-cuo-%C3%AE-mno2-hybrid-composites-for-catalytic-total-oxidation-of-toluene-pollutant
#18
Luming Li, Jingjie Luo, Yuefeng Liu, Fangli Jing, Dangsheng Su, Wei Chu
A new self-propagated flaming (SPF) technique was applied to the synthesis of highly active layered CuO-δ-MnO2 hybrid composites, for the de-polluting catalytic total oxidation of gaseous toluene vapor. Other transition metal oxide-doped MnO2 hybrid composites were also successfully prepared and investigated, ensuring a feasible strategy for the fabrication of various layered MOx-δ-MnO2 (M=Co, Ni or Zn) hybrids. By changing the molar ratio of the precursors (KMnO4 and acetate salt) and the type of transition metal oxide introduced, it is possible to control the crystal structure and reducibility of the sheet-like hybrid composites as well as the catalytic activity for the total oxidation of toluene...
June 7, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28587715/diffusion-weighted-whole-body-mri-for-evaluation-of-early-response-in-multiple-myeloma
#19
C Lacognata, F Crimì, A Guolo, C Varin, E De March, S Vio, A Ponzoni, G Barilà, A Lico, A Branca, E De Biasi, F Gherlinzoni, V Scapin, E Bissoli, T Berno, R Zambello
AIM: To evaluate the modifications of the apparent diffusion coefficient (ADC) in myelomatous lesions before and after induction treatment and the correlation with patient response to therapy according to International Myeloma Working Group (IMWG) criteria. MATERIALS AND METHODS: A homogeneous group of 18 patients with a diagnosis of symptomatic multiple myeloma who underwent whole-body MRI with diffusion-weighted imaging (DWI-MRI) before and after bortezomib-based induction chemotherapy were evaluated prospectively...
June 3, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28582700/effects-of-road-salt-on-larval-amphibian-susceptibility-to-parasitism-through-behavior-and-immunocompetence
#20
Dino Milotic, Marin Milotic, Janet Koprivnikar
Large quantities of road salts are used for de-icing in temperate climates but often leach into aquatic ecosystems where they can cause harm to inhabitants, including reduced growth and survival. However, the implications of road salt exposure for aquatic animal susceptibility to pathogens and parasites have not yet been examined even though infectious diseases can significantly contribute to wildlife population declines. Through a field survey, we found a range of NaCl concentrations (50-560mg/L) in ponds known to contain larval amphibians, with lower levels found in sites close to gravel- rather than hard-surfaced roads...
May 31, 2017: Aquatic Toxicology
keyword
keyword
97313
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"