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https://www.readbyqxmd.com/read/29771683/an-individualized-strategy-to-estimate-the-effect-of-deformable-registration-uncertainty-on-accumulated-dose-in-the-upper-abdomen
#1
Yibing Wang, Steven F Petit, Eliana Vasquez Osorio, Vikas Gupta, Alejandra Méndez Romero, Ben J M Heijmen
In the abdomen, it is challenging to assess the accuracy of deformable image registration (DIR) for individual patients, due to the lack of clear anatomical landmarks, which can hamper clinical applications that require high accuracy DIR, such as adaptive radiotherapy. In this study, we propose and evaluate a methodology for estimating the impact of uncertainties in DIR on calculated accumulated dose in the upper abdomen, in order to aid decision making in adaptive treatment approaches. 
 Sixteen liver metastasis patients treated with SBRT were evaluated...
May 17, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29750538/stereotactic-body-radiation-therapy-for-liver-oligometastases-predictive-factors-of-local-response-by-18f-fdg-pet-ct
#2
Rosario Mazzola, Sergio Fersino, Pierpaolo Alongi, Gioacchino Di Paola, Fabiana Gregucci, Dario Aiello, Umberto Tebano, Stefano Pasetto, Ruggero Ruggieri, Matteo Salgarello, Filippo Alongi
OBJECTIVE: to investigate metabolic parameters as predictive of local response after Stereotactic Body Radiation Therapy (SBRT) for liver-oligometastases Methods: Inclusion criteria of the present retrospective study were: a) liver oligometastases with controlled primary tumor; b) absence of progressive disease ≥6 months; c) metastases ≤ 3; d) evaluation of SBRT-response by means of 18-FDG-PET/CT for at least two subsequent evaluations; e) Karnofsky performance status >80; f) life-expectancy >6 months...
May 11, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29750133/use-of-indirect-target-gating-in-magnetic-resonance-guided-liver-stereotactic-body-radiotherapy-case-report-of-an-oligometastatic-patient
#3
Luca Boldrini, Francesco Cellini, Stefania Manfrida, Giuditta Chiloiro, Stefania Teodoli, Davide Cusumano, Bruno Fionda, Gian Carlo Mattiucci, Anna Maria De Gaetano, Luigi Azario, Vincenzo Valentini
The case of a 73-year-old woman affected by anal canal cancer with concomitant liver metastases is presented here. The patient was addressed to stereotactic body radiotherapy (SBRT) on two hepatic secondary lesions after the first radiochemotherapy treatment of the primary tumor. A Tri-60-Co magnetic resonance hybrid radiotherapy unit was used for SBRT treatment delivery. Both liver lesions were not clearly visible on the setup magnetic resonance imaging (MRI) due to their limited dimensions (maximum diameter 13 mm); however, the presence of two cysts adjacent to the metastases allowed the use of an indirect target gating approach...
March 9, 2018: Curēus
https://www.readbyqxmd.com/read/29688858/additional-chemotherapy-improved-local-control-and-overall-survival-after-stereotactic-body-radiation-therapy-for-patients-with-oligo-recurrence
#4
Masaki Nakamura, Naoki Hashimoto, Hiroshi Mayahara, Haruka Uezono, Aya Harada, Ryo Nishikawa, Yoshiro Matsuo, Hiroki Kawaguchi, Hideki Nishimura
BACKGROUND: Oligo-recurrence has been considered to confer improved prognosis than other oligometastatic conditions, and stereotactic body radiation therapy (SBRT) is considered as an option of local therapy for lung or liver metastases. The purpose of this study was to investigate the efficacy and safety of SBRT for lung and liver oligo-recurrent lesions and evaluate predictive factors for local control and prognosis. METHODS: This retrospective study included patients who presented with 1-3 matachronous lung or liver metastases, and treated with SBRT between May 2013 and March 2016 at a single institution...
April 23, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29606523/influence-of-deformable-image-registration-on-4d-dose-simulation-for-extracranial-sbrt-a-multi-registration-framework-study
#5
Nik Mogadas, Thilo Sothmann, Tobias Knopp, Tobias Gauer, Cordula Petersen, René Werner
BACKGROUND AND PURPOSE: To evaluate the influence of deformable image registration approaches on correspondence model-based 4D dose simulation in extracranial SBRT by means of open source deformable image registration (DIR) frameworks. MATERIAL AND METHODS: Established DIR algorithms of six different open source DIR frameworks were considered and registration accuracy evaluated using freely available 4D image data. Furthermore, correspondence models (regression-based correlation of external breathing signal measurements and internal structure motion field) were built and model accuracy evaluated...
March 29, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29559289/a-prospective-cohort-study-of-gated-stereotactic-liver-radiation-therapy-using-continuous-internal-electromagnetic-motion-monitoring
#6
Esben S Worm, Morten Høyer, Rune Hansen, Lars P Larsen, Britta Weber, Cai Grau, Per R Poulsen
PURPOSE: Intrafraction motion can compromise the treatment accuracy in liver stereotactic body radiation therapy (SBRT). Respiratory gating can improve treatment delivery; however, gating based on external motion surrogates is inaccurate. The present study reports the use of Calypso-based internal electromagnetic motion monitoring for gated liver SBRT. METHODS AND MATERIALS: Fifteen patients were included in a study of 3-fraction respiratory gated liver SBRT guided by 3 implanted electromagnetic transponders...
February 13, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29553972/stereotactic-body-radiation-therapy-sbrt-for-hepatocellular-carcinoma-high-rates-of-local-control-with-low-toxicity
#7
Brian C Baumann, Jenny Wei, John P Plastaras, John N Lukens, Nevena Damjanov, Maarouf Hoteit, Christine Hsu, Matthew Levine, Jeffrey Mondschein, Gregory Nadolski, Kim Olthoff, Kim A Reiss, Mark Rosen, Evan Siegelman, James M Metz, Edgar Ben-Josef
OBJECTIVES: Stereotactic body radiotherapy (SBRT) is potentially curative treatment for small hepatocellular carcinomas (HCC), but data are limited on its efficacy and toxicity. We hypothesized that SBRT can achieve excellent local control (LC) with acceptable toxicity treating HCC lesions, even in advanced cirrhosis. MATERIALS AND METHODS: Thirty-seven nonmetastatic HCC patients received SBRT to 43 lesions between October 2012 and April 2016. Median dose was 50 Gy/5 fractions...
March 16, 2018: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29542260/comparative-analysis-for-renal-stereotactic-body-radiotherapy-using-cyberknife-vmat-and-proton-therapy-based-treatment-planning
#8
Atallah Baydoun, Neha Vapiwala, Lee E Ponsky, Musaddiq Awan, Ali Kassaee, David Sutton, Tarun K Podder, Yuxia Zhang, Donald Dobbins, Raymond F Muzic, Bryan Traughber, Mitchell Machtay, Rodney Ellis
PURPOSE: We conducted this dosimetric analysis to evaluate the feasibility of a multi-center stereotactic body radiation therapy (SBRT) trial for renal cell carcinoma (RCC) using different SBRT platforms. MATERIALS/METHODS: The computed tomography (CT) simulation images of 10 patients with unilateral RCC previously treated on a Phase 1 trial at Institution 1 were anonymized and shared with Institution 2 after IRB approval. Treatment planning was generated through five different platforms aiming a total dose of 48 Gy in three fractions...
March 14, 2018: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29534687/the-sbrt-database-initiative-of-the-german-society-for-radiation-oncology-degro-patterns-of-care-and-outcome-analysis-of-stereotactic-body-radiotherapy-sbrt-for-liver-oligometastases-in-474-patients-with-623-metastases
#9
N Andratschke, H Alheid, M Allgäuer, G Becker, O Blanck, J Boda-Heggemann, T Brunner, M Duma, S Gerum, M Guckenberger, G Hildebrandt, R J Klement, V Lewitzki, C Ostheimer, A Papachristofilou, C Petersen, T Schneider, R Semrau, S Wachter, D Habermehl
BACKGROUND: The intent of this pooled analysis as part of the German society for radiation oncology (DEGRO) stereotactic body radiotherapy (SBRT) initiative was to analyze the patterns of care of SBRT for liver oligometastases and to derive factors influencing treated metastases control and overall survival in a large patient cohort. METHODS: From 17 German and Swiss centers, data on all patients treated for liver oligometastases with SBRT since its introduction in 1997 has been collected and entered into a centralized database...
March 13, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29516868/automatic-online-and-real-time-tumour-motion-monitoring-during-stereotactic-liver-treatments-on-a-conventional-linac-by-combined-optical-and-sparse-monoscopic-imaging-with-kilovoltage-x-rays-cosmik
#10
Jenny Bertholet, Jakob Toftegaard, Rune Hansen, Esben S Worm, Hanlin Wan, Parag J Parikh, Britta Weber, Morten Høyer, Per R Poulsen
The purpose of this study was to develop, validate and clinically demonstrate fully automatic tumour motion monitoring on a conventional linear accelerator by combined optical and sparse monoscopic imaging with kilovoltage x-rays (COSMIK). COSMIK combines auto-segmentation of implanted fiducial markers in cone-beam computed tomography (CBCT) projections and intra-treatment kV images with simultaneous streaming of an external motion signal. A pre-treatment CBCT is acquired with simultaneous recording of the motion of an external marker block on the abdomen...
March 8, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29493095/evaluation-of-the-intra-and-interfractional-tumor-motion-and-variability-by-fiducial-based-real-time-tracking-in-liver-stereotactic-body-radiation-therapy
#11
Zhiwen Liang, Hongyuan Liu, Jun Xue, Bin Hu, Bin Zhu, Qin Li, Sheng Zhang, Gang Wu
PURPOSE: Tumor motion amplitude varies during treatment. The purpose of the study was to evaluate the intra- and interfraction tumor motion and variability in patients with liver cancer treated with fiducial-based real-time tracking stereotactic body radiotherapy (SBRT). METHODS: Fourteen liver patients were treated with SBRT using a CyberKnife. Two to four fiducial markers implanted near the tumor were used for real-time monitoring using the Synchrony system. The tumor motion information during treatment was extracted from the log files recorded by the Synchrony system...
February 28, 2018: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29491079/dose-function-histogram-evaluation-using-99m-tc-gsa-spect-ct-images-for-stereotactic-body-radiation-therapy-planning-for-hepatocellular-carcinoma-patients-a-dosimetric-parameter-comparison
#12
COMPARATIVE STUDY
Ryo Toya, Tetsuo Saito, Shinya Shiraishi, Yudai Kai, Ryuji Murakami, Tomohiko Matsuyama, Takahiro Watakabe, Fumi Sakamoto, Noriko Tsuda, Yoshinobu Shimohigashi, Yasuyuki Yamashita, Natsuo Oya
BACKGROUND/AIM: We evaluated the influence of previous treatments on the parametric discrepancies between dose-volume histograms (DVHs) and dose-function histograms (DFHs) generated based on 99m Tc-GSA SPECT images of hepatocellular carcinoma (HCC) patients treated with stereotactic body radiation therapy (SBRT). PATIENTS AND METHODS: Twelve patients underwent SBRT at 30-40 Gy. Registration between planning CT and SPECT/CT images was performed, and DFH parameters were calculated as follows: Fx=(sum of the counts within the liver volume receiving a dose of more than x Gy/sum of the counts within the whole liver volume) ×100...
March 2018: Anticancer Research
https://www.readbyqxmd.com/read/29485074/comparison-of-stereotactic-body-radiation-therapy-and-radiofrequency-ablation-in-the-treatment-of-intrahepatic-metastases
#13
William C Jackson, Yebin Tao, Mishal Mendiratta-Lala, Latifa Bazzi, Dan R Wahl, Matthew J Schipper, Mary Feng, Kyle C Cuneo, Theodore S Lawrence, Dawn Owen
PURPOSE: Stereotactic body radiation therapy (SBRT) and radiofrequency ablation (RFA) are widely used therapies for the treatment of intrahepatic metastases; however, direct comparisons are lacking. We sought to compare outcomes for these 2 modalities. METHODS AND MATERIALS: From 2000 to 2015, 161 patients with 282 pathologically diagnosed unresectable liver metastases were treated with RFA (n = 112) or SBRT (n = 170) at a single institution. The primary outcome was freedom from local progression (FFLP)...
March 15, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29482870/radiation-dose-volume-effects-for-liver-sbrt
#14
Moyed Miften, Yevgeniy Vinogradskiy, Vitali Moiseenko, Jimm Grimm, Ellen Yorke, Andrew Jackson, Wolfgang A Tomé, Randall K Ten Haken, Nitin Ohri, Alejandra Méndez Romero, Karyn A Goodman, Lawrence B Marks, Brian Kavanagh, Laura A Dawson
Stereotactic body radiation therapy (SBRT) has emerged as an effective, noninvasive treatment option for primary liver cancer and metastatic disease occurring in the liver. Although SBRT can be highly effective for establishing local control in hepatic malignancies, a tradeoff exists between tumor control and normal tissue complications. The objective of the present study was to review the normal tissue dose-volume effects for SBRT-induced liver and gastrointestinal toxicities and derive normal tissue complication probability models...
January 6, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29480814/estimation-of-patient-specific-imaging-dose-for-real-time-tumour-monitoring-in-lung-patients-during-respiratory-gated-radiotherapy
#15
Takehiro Shiinoki, Ryota Onizuka, Daisuke Kawahara, Tatsuhiko Suzuki, Yuki Yuasa, Koya Fujimoto, Takuya Uehara, Hideki Hanazawa, Keiko Shibuya
PURPOSE: To quantify the patient-specific imaging dose for real-time tumour monitoring in the lung during respiratory-gated stereotactic body radiotherapy (SBRT) in clinical cases using SyncTraX. METHODS AND MATERIALS: Ten patients who underwent respiratory-gated SBRT with SyncTraX were enrolled in this study. The imaging procedure for real-time tumour monitoring using SyncTraX was simulated using Monte Carlo. We evaluated the dosimetric effect of a real-time tumour monitoring in a critical organ at risk (OAR) and the planning target volume (PTV) over the course of treatment...
March 21, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29472086/image-quality-of-four-dimensional-cone-beam-computed-tomography-obtained-at-various-gantry-rotation-speeds-for-liver-stereotactic-body-radiation-therapy-with-fiducial-markers
#16
Yoshinobu Shimohigashi, Fujio Araki, Masato Maruyama, Keisuke Yonemura, Yuji Nakaguchi, Yudai Kai, Ryo Toya
In this study, qualities of 4D cone-beam CT (CBCT) images obtained using various gantry rotation speeds (GRSs) for liver stereotactic body radiation therapy (SBRT) with fiducial markers were quantitatively evaluated. Abdominal phantom containing a fiducial marker was moved along a sinusoidal waveform, and 4D-CBCT images were acquired with GRSs of 50-200° min-1 . We obtained the 4D-CBCT projection data from six patients who underwent liver SBRT and generated 4D-CBCT images at GRSs of 67-200° min-1 , by varying the number of projection data points...
January 2018: Physica Medica: PM
https://www.readbyqxmd.com/read/29463958/interfractional-diaphragm-changes-during-breath-holding-in-stereotactic-body-radiotherapy-for-liver-cancer
#17
Daisuke Kawahara, Shuichi Ozawa, Takeo Nakashima, Shintaro Tsuda, Yusuke Ochi, Takuro Okumura, Hirokazu Masuda, Kazunari Hioki, Tathsuhiko Suzuki, Yoshimi Ohno, Tomoki Kimura, Yuji Murakami, Yasushi Nagata
Aim and background: IGRT based on bone matching may produce a large target positioning error in terms of the reproducibility of expiration breath-holding on SBRT for liver cancer. We evaluated the intrafractional and interfractional errors using the diaphragm position at the end of expiration by utilising Abches and analysed the factor of the interfractional error. Materials and methods: Intrafractional and interfractional errors were measured using a couple of frontal kV images, planning computed tomography (pCT) and daily cone-beam computed tomography (CBCT)...
March 2018: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/29463266/unresectable-hepatic-pecoma-a-rare-malignancy-treated-with-stereotactic-body-radiation-therapy-sbrt-followed-by-complete-resection
#18
Simon Kirste, Gian Kayser, Anne Zipfel, Anca-Ligia Grosu, Thomas Brunner
BACKGROUND: Perivascular epithelioid cell tumors (PEComas) are rare mesenchymal tumors occurring in various anatomic regions. Although diagnostic criteria and treatment management are not established, current treatment options consist of surgery and chemotherapy including mTOR inhibitors. Stereotactic body radiation therapy (SBRT) is a non-invasive ablative treatment which has shown excellent control rates for more common types of unresectable liver tumors and metastases. In this report we present a rare case of PEComa of the liver that was treated by stereotactic radiotherapy followed by resection...
February 20, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29450985/effect-of-secondary-electron-generation-on-dose-enhancement-in-lipiodol-with-and-without-a-flattening-filter
#19
Daisuke Kawahara, Shuichi Ozawa, Akito Saito, Tomoki Kimura, Tatsuhiko Suzuki, Masato Tsuneda, Sodai Tanaka, Takeo Nakashima, Yoshimi Ohno, Yuji Murakami, Yasushi Nagata
PURPOSE: Lipiodol, which was used in transcatheter arterial chemoembolization before liver stereotactic body radiation therapy (SBRT), remains in SBRT. Previous we reported the dose enhancement in Lipiodol using 10 MV (10×) FFF beam. In this study, we compared the dose enhancement in Lipiodol and evaluated the probability of electron generation (PEG) for the dose enhancement using flattening filter (FF) and flattening filter free (FFF) beams. METHODS: FF and FFF for 6 MV (6×) and 10× beams were delivered by TrueBeam...
March 2018: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29439707/stereotactic-body-radiotherapy-sbrt-for-liver-metastasis-clinical-outcomes-from-the-international-multi-institutional-rssearch%C3%A2-patient-registry
#20
Anand Mahadevan, Oliver Blanck, Rachelle Lanciano, Anuj Peddada, Srinath Sundararaman, David D'Ambrosio, Sanjeev Sharma, David Perry, James Kolker, Joanne Davis
BACKGROUND: Stereotactic body radiotherapy (SBRT) is an emerging treatment option for liver metastases in patients unsuitable for surgery. We investigated factors associated with clinical outcomes for liver metastases treated with SBRT from a multi-center, international patient registry. METHODS: Patients with liver metastases treated with SBRT were identified in the RSSearch® Patient Registry. Patient, tumor and treatment characteristics associated with treatment outcomes were assessed...
February 13, 2018: Radiation Oncology
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