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fluconazole abdominal surgery

Ingmar Fortmann, Annika Hartz, Pia Paul, Ferdinand Pulzer, Andreas Müller, Ralf Böttger, Hans Proquitté, Kristin Dawczynski, Arne Simon, Jan Rupp, Egbert Herting, Wolfgang Göpel, Christoph Härtel
INTRODUCTION: The diagnostic proof of fungal infection in preterm infants is difficult. Antifungal treatment (AFT) is often initiated empirically when infants with suspected infection do not improve despite broad spectrum antibiotic therapy. It was the aim of our study to determine the rate of exposure to empirical AFT in a large cohort of very low birth weight infants (VLBWI) of the German Neonatal Network (GNN) and to address associated risks and outcomes. METHODS: The epidemiological database consisted of n= 13...
March 29, 2018: Pediatric Infectious Disease Journal
Cigdem Mermutluoglu, Ozcan Deveci, Saim Dayan, Emel Aslan, Fatma Bozkurt, Recep Tekin
OBJECTIVE: This study aimed to investigate the antifungal susceptibility, typology, and risk factors of candidemia among adult and pediatric inpatients at a university hospital. MATERIALS AND METHODS: A case-control study was designed, and data collected between December 2013 and December 2014 were retrospectively evaluated. The case group consisted of patients with candidemia. The control group was selected from the inpatients that did not develop candidemia but were admitted in the same clinic and during the same period as the candidemia group...
October 2016: Eurasian Journal of Medicine
Renata Toth, Adel Toth, Csaba Vagvolgyi, Attila Gacser
The prevalence of Candida parapsilosis, an opportunistic human pathogenic fungal species, is increasing at an alarming rate in the hospital environment. Patients at risk for C. parapsilosis infection include those with immunosuppression, such as individuals with cancer, AIDS, and low birth weight premature neonates as well as patients that had undergone abdominal surgery. Neonatal candidiasis caused by C. parapsilosis has been widely reported across the globe. Various reports have shown that, compared to other Candida species, certain C...
2017: Current Protein & Peptide Science
Agathe Herb, Marcela Sabou, Jean-Baptiste Delhorme, Patrick Pessaux, Didier Mutter, Ermanno Candolfi, Valérie Letscher-Bru
Pseudozyma aphidis is an environmental Basidiomycete yeast, and has been involved in the ten past years in rare cases of invasive infection. Pseudozyma species are naturally resistant to caspofungin and often present decreased susceptibility or resistance to fluconazole. This fungus may be difficult to recognize and misidentifications are reported with conventional phenotypical methods. We report a case of P. aphidis invasive infection in an adult with a metastatic ampulloma who had gone through digestive surgery...
June 2015: Medical Mycology Case Reports
Lindsay Tangeman, Danielle Davignon, Reema Patel, Meryl Littman
Canine cryptococcosis cases are typically reported as neurologic, disseminated, or both. There have been few reports of other parenchymal organ involvement. Dogs infected with Cryptococcus spp. are likely to develop central nervous system involvement, and those that are severely affected are treated aggressively with surgery and/or amphotericin B. This report describes two cases of canine abdominal cryptococcosis: one boxer with primary alimentary cryptococcosis alone and one miniature schnauzer with pancreatic and disseminated cryptococcosis...
March 2015: Journal of the American Animal Hospital Association
Patricia Fernanda Herkert, Renata Rodrigues Gomes, Marisol Dominguez Muro, Rosangela Lameira Pinheiro, Gheniffer Fornari, Vânia Aparecida Vicente, Flávio Queiroz-Telles
BACKGROUND: Candida species are the main cause of hospital acquired fungal bloodstream infections. The main risk factors for candidemia include parenteral nutrition, long-term intensive care, neutropenia, diabetes, abdominal surgery and the use of central venous catheters. The antifungal drugs used to treat candidemia are mainly the echinocandins, however some isolates may be resistant to these drugs. AIMS: This work aims to evaluate the in vitro susceptibility patterns of various Candida species isolated from blood samples and provide their identification by molecular characterization...
October 2015: Revista Iberoamericana de Micología
L Klingspor, A M Tortorano, J Peman, B Willinger, P Hamal, B Sendid, A Velegraki, C Kibbler, J F Meis, R Sabino, M Ruhnke, S Arikan-Akdagli, J Salonen, I Dóczi
A prospective, observational, multicentre study of invasive candidosis (IC) in surgical patients in intensive care units (ICUs) was conducted from 2006 to 2008 in 72 ICUs in 14 European countries. A total of 779 patients (62.5% males, median age 63 years) with IC were included. The median rate of candidaemia was 9 per 1000 admissions. In 10.8% the infection was already present at the time of admission to ICU. Candida albicans accounted for 54% of the isolates, followed by Candida parapsilosis 18.5%, Candida glabrata 13...
January 2015: Clinical Microbiology and Infection
Marya Zilberberg, Hsing-Ting Yu, Paresh Chaudhari, Matthew F Emons, Nikhil Khandelwal, Andrew F Shorr
INTRODUCTION: Historically, Candida albicans has represented the most common cause of candidemia. However, the proportion of bloodstream infections due to non-albicans Candida species has increased. Because of the risk for candidemia in intra-abdominal surgical patients, some experts advocate the use of fluconazole prophylaxis. The impact of this practice on the distribution of Candida species isolated in breakthrough fungal infections in this population is unknown. We examined the association of fluconazole prophylaxis with the distribution of Candida species in intra-abdominal surgery patients...
October 29, 2014: Critical Care: the Official Journal of the Critical Care Forum
Guillermo Quindós
Invasive candidiasis is a leading cause of mortality. Candidaemia is the most common clinical presentation of invasive candidiasis but more that 30% of these infections do not yield positive blood cultures. Candida albicans remains the predominant aetiology, accounting for 50% of all cases. However, there has been an epidemiological shift in the last decades. Some species of Candida different to C. albicans have emerged as an important cause of severe candidaemia as they can exhibit resistance to fluconazole and other antifungal agents...
January 2014: Revista Iberoamericana de Micología
Maiken Cavling Arendrup
In our part of the world invasive fungal infections include invasive yeast infections with Candida as the absolutely dominating pathogen and invasive mould infections with Aspergillus as the main organism. Yeasts are part of our normal micro-flora and invasive infections arise only when barrier leakage or impaired immune function occurs. On the contrary, moulds are ubiquitous in the nature and environment and their conidia inhaled at a daily basis. Hence invasive mould infections typically arise from the airways whereas invasive yeast infections typically enter the bloodstream causing fungaemia...
November 2013: Danish Medical Journal
Matteo Bassetti, Monia Marchetti, Arunaloke Chakrabarti, Sergio Colizza, Jose Garnacho-Montero, Daniel H Kett, Patricia Munoz, Francesco Cristini, Anastasia Andoniadou, Pierluigi Viale, Giorgio Della Rocca, Emmanuel Roilides, Gabriele Sganga, Thomas J Walsh, Carlo Tascini, Mario Tumbarello, Francesco Menichetti, Elda Righi, Christian Eckmann, Claudio Viscoli, Andrew F Shorr, Olivier Leroy, George Petrikos, Francesco Giuseppe De Rosa
INTRODUCTION: intra-abdominal candidiasis (IAC) may include Candida involvement of peritoneum or intra-abdominal abscess and is burdened by high morbidity and mortality rates in surgical patients. Unfortunately, international guidelines do not specifically address this particular clinical setting due to heterogeneity of definitions and scant direct evidence. In order to cover this unmet clinical need, the Italian Society of Intensive Care and the International Society of Chemotherapy endorsed a project aimed at producing practice recommendations for the management of immune-competent adult patients with IAC...
December 2013: Intensive Care Medicine
W Hasibeder, M Halabi
BACKGROUND: Fungal infections including Candida peritonitis (CP) are being observed with increasing frequency in the ICU. We summarize current knowledge on epidemiology, risk factors, diagnostic tests and treatment options in the previously immunocompetent patient suffering from CP. METHODS: An electronic medical database search using "Candida" and "Peritonitis" as main search terms in conjunction with specific key words relevant to the topic. RESULTS: CP is associated with high mortality particularly after complicated abdominal surgery and in the presence of severe sepsis or septic shock...
April 2014: Minerva Anestesiologica
Chun-fang Ma, Fang-qiu Li, Li-ning Shi, Yu-an Hu, Ying Wang, Mei Huang, Qian-qian Kong
BACKGROUND: Bloodstream infections due to Candida species cause significant morbidity and mortality, and the epidemiology of Candida infection is changing. Surveillance for candidemia is necessary to detect trends in species distribution and antifungal resistance. METHODS: The medical and electronic records of all patients who had candidemia at the authors' hospital from 2009 to 2011 were reviewed for demographic data and clinical information, including the infecting Candida species, resistance to antifungals and survival, and the presence of risk factors associated with candidemia...
2013: BMC Infectious Diseases
Emilio Maseda, Santiago Ernesto Denis, Ana Riquelme, Fernando Gilsanz
Intra-abdominal infection (IAI) is a frequent complication found in surgical intensive care unit (SICU) and continues to be associated with considerable mortality. Tigecycline, the first-in-class glycylcycline has demonstrated a broad spectrum of activity against a wide range of bacteria commonly found in IAI. This observational retrospective study aimed to describe the experience with tigecycline for serious nosocomial IAI in the SICU. Data were collected from 23 consecutive patients admitted to SICU with serious nococomial IAI who had received empirical treatment with tigecycline...
March 2013: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
A Pérez-Lanzac, J Soto-Villalva, M J Ledo-Cepero, R Garcia-Baquero, J Rosety-Rodriguez, B Madurga-Patuel, J L Alvarez-Ossorio-Fernández
INTRODUCTION: Laparoscopic surgery is following a natural course as it decreases surgical aggression on the abdominal wall without undermining the curative and functional results. Although it is still being developed, single port surgery has meant an advance in this sense. MATERIAL AND METHODS: We present the first single port laparoscopic pyelolithectomy surgery in horseshoe kidney, using conventional rigid instruments. The case of an 18-year old patient with BMI of 19 in whom the imaging tests (urogram and computed tomography) showed a horseshoe kidney with left coralliform lithiasis and discrete calyceal ectasia is presented...
May 2013: Actas Urologicas Españolas
Małgorzata Mikulska, Valerio Del Bono, Sandra Ratto, Claudio Viscoli
Candida is one of the most common causes of nosocomial bloodstream infections. Candidemia is not confined to hematological patients, intensive care units or abdominal surgery wards, but it is remarkably frequent in the internal medicine setting. High mortality associated with candidemia can be reduced by prompt, appropriate antifungal therapy. The epidemiology of species has been shifting toward non-albicans strains. Significant improvements in nonculture-based diagnostic methods, such as serological markers, have been made in recent years, and novel diagnostic techniques should be further studied to enable early pre-emptive therapy...
November 2012: Expert Review of Clinical Immunology
O A Cornely, M Bassetti, T Calandra, J Garbino, B J Kullberg, O Lortholary, W Meersseman, M Akova, M C Arendrup, S Arikan-Akdagli, J Bille, E Castagnola, M Cuenca-Estrella, J P Donnelly, A H Groll, R Herbrecht, W W Hope, H E Jensen, C Lass-Flörl, G Petrikkos, M D Richardson, E Roilides, P E Verweij, C Viscoli, A J Ullmann
This part of the EFISG guidelines focuses on non-neutropenic adult patients. Only a few of the numerous recommendations can be summarized in the abstract. Prophylactic usage of fluconazole is supported in patients with recent abdominal surgery and recurrent gastrointestinal perforations or anastomotic leakages. Candida isolation from respiratory secretions alone should never prompt treatment. For the targeted initial treatment of candidaemia, echinocandins are strongly recommended while liposomal amphotericin B and voriconazole are supported with moderate, and fluconazole with marginal strength...
December 2012: Clinical Microbiology and Infection
Anastasia Spiliopoulou, Evangelos D Anastassiou, Myrto Christofidou
Rhodotorula species are commensal yeasts that have emerged as a cause of life-threatening fungemia in severely immunocompromised patients. A case of Rhodotorula mucilaginosa fungemia in a 48-year-old woman that had undergone consecutive abdominal surgeries due to ovarian cancer and bowel necrosis while she was receiving fluconazole prophylaxis is presented. Several risk factors were identified such as presence of central venous catheters, solid organ neoplasm, abdominal surgery and administration of antibiotics...
October 2012: Mycopathologia
Stefan Weichert, Konrad Reinshagen, Katrin Zahn, Gernot Geginat, Annebärbel Dietz, Anna Kristina Kilian, Horst Schroten, Tobias Tenenbaum
BACKGROUND: Systemic Candidia infections are of major concern in neonates, especially in those with risk factors such as longer use of broad spectrum antibiotics. Recent studies showed that also term babies with underlying gastrointestinal or urinary tract abnormalities are much more prone to systemic Candida infection. We report a very rare case of candidiasis caused by Candida kefyr in a term neonate. CASE PRESENTATION: Renal agenesis on the left side was diagnosed antenatally and anal atresia postnatally...
March 18, 2012: BMC Infectious Diseases
M Ruhnke, J A Paiva, W Meersseman, J Pachl, I Grigoras, G Sganga, F Menichetti, P Montravers, G Auzinger, G Dimopoulos, M Borges Sá, P J Miller, T Marček, M Kantecki
A prospective, multicentre, phase IIIb study with an exploratory, open-label design was conducted to evaluate efficacy and safety of anidulafungin for the treatment of candidaemia/invasive candidiasis (C/IC) in specific ICU patient populations. Adult ICU patients with confirmed C/IC meeting ≥ 1 of the following criteria were enrolled: post-abdominal surgery, solid tumour, renal/hepatic insufficiency, solid organ transplant, neutropaenia, and age ≥ 65 years. Patients received anidulafungin (200 mg on day 1, 100 mg/day thereafter) for 10-42 days, optionally followed by oral voriconazole/fluconazole...
July 2012: Clinical Microbiology and Infection
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