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the st george respiratory questionnaire

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https://www.readbyqxmd.com/read/28740376/fluticasone-propionate-formoterol-for-copd-management-a-randomized-controlled-trial
#1
A Papi, D Dokic, W Tzimas, I Mészáros, A Olech-Cudzik, Z Koroknai, K McAulay, S Mersmann, P S Dalvi, T Overend
PURPOSE: To evaluate fluticasone propionate/formoterol (FP/FORM) in COPD. PATIENTS AND METHODS: COPD patients with forced expiratory volume in 1 s (FEV1) ≤50% predicted and ≥1 moderate/severe COPD exacerbation in the last 12 months were randomized to FP/FORM 500/20 or 250/10 µg bid, or formoterol (FORM) 12 µg bid for 52 weeks. The primary outcome was the annualized rate of moderate/severe COPD exacerbations. RESULTS: In total, 1,765 patients were randomized...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28733270/evaluating-a-web-based-coaching-program-using-electronic-health-records-for-patients-with-chronic-obstructive-pulmonary-disease-in-china-randomized-controlled-trial
#2
Lan Wang, Lin He, Yanxia Tao, Li Sun, Hong Zheng, Yashu Zheng, Yuehao Shen, Suyan Liu, Yue Zhao, Yaogang Wang
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is now the fourth leading cause of death in the world, and it continues to increase in developing countries. The World Health Organization expects COPD to be the third most common cause of death in the world by 2020. Effective and continuous postdischarge care can help patients to maintain good health. The use of electronic health records (EHRs) as an element of community health care is new technology in China. OBJECTIVE: The aim of this study was to develop and evaluate a Web-based coaching program using EHRs for physical function and health-related quality of life for patients with COPD in China...
July 21, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28732839/exacerbations-and-duration-of-smoking-abstinence-are-associated-with-the-annual-loss-of-fev1-in-individuals-with-pizz-alpha-1-antitrypsin-deficiency
#3
Sebastian Fähndrich, Nikolas Bernhard, Philipp M Lepper, Claus Vogelmeier, Martina Seibert, Stefan Wagenpfeil, Robert Bals
BACKGROUND: Alpha-1-antitrypsin deficiency (AATD) is a genetic disorder that is associated with a higher risk of chronic obstructive pulmonary disease (COPD) and emphysema. The annual declines in lung function (FEV1) and transfer factor of the lung for carbon monoxide (TLCO) predict all-cause mortality. MATERIAL AND METHODS: We investigated the longitudinal follow-up data over 11 years (mean follow-up period of 4.89 years) from the German AATD registry and analyzed the relationship between annual loss of FEV1 and TLCO and sex, age, body mass index (BMI), nicotine consumption, occupational dust exposure, St...
August 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28728439/translation-of-the-leicester-cough-questionnaire-into-swedish-and-validity-and-reliability-in-chronic-obstructive-pulmonary-disease
#4
Pernilla Sönnerfors, Gun Faager, Ulrika Einarsson
PURPOSE: The purpose of this study was to translate and culturally adapt the Leicester Cough Questionnaire into Swedish and to test the validity and reliability of the Swedish version, in patients with chronic obstructive pulmonary disease. METHODS: The original Leicester Cough Questionnaire was translated into Swedish by a method, which followed an established forward-backward procedure, including cross-cultural adaptation and pretest. To test the validity of the final version of Leicester Cough Questionnaire in Swedish, the St George's Respiratory Questionnaire and the COPD Assessment Test were used (n =112) and to test reliability, the questionnaire was repeated (n = 86)...
July 20, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28727669/differential-pulmonary-rehabilitation-outcomes-in-patients-with-and-without-copd-role-of-gender
#5
Lam-Phuong Nguyen, Emily Beck, Katherine Cayetano, Chin-Shang Li, Kimberly Hardin
PURPOSE: Individuals with all forms of pulmonary disease are referred for pulmonary rehabilitation. This study examines pulmonary rehabilitation outcomes between individuals with chronic obstructive lung disease (COPD) and non-COPD disease and the impact of gender. METHODS: This is a retrospective study at a tertiary center. The primary endpoint was the difference in 6-min walk test distance. Secondary measurements included treadmill and NuStep minutes; biceps curls and front arm raises load; quality of life measured by the St George's Respiratory Questionnaire; and University of California San Diego-Shortness of Breath Questionnaire (UCSD-SOBQ) scores...
July 19, 2017: Journal of Cardiopulmonary Rehabilitation and Prevention
https://www.readbyqxmd.com/read/28720336/baseline-symptom-score-impact-on-benefits-of-glycopyrrolate-formoterol-mdi-in-copd
#6
Fernando J Martinez, Leonardo M Fabbri, Gary T Ferguson, Chad Orevillo, Patrick Darken, Ubaldo J Martin, Colin Reisner
BACKGROUND: Chronic obstructive pulmonary disease (COPD) clinical severity is presently categorized by symptom burden and exacerbation risk. Previous 24-week Phase III trials (NCT01854645 and NCT01854658) that demonstrated better improvement of lung function with GFF MDI, a metered dose inhaler fixed-dose combination of glycopyrrolate/formoterol fumarate 18/9.6 μg, over individual monocomponent MDIs included a cross-section of patients with moderate-to-very severe airflow limitation and a broad range of COPD symptoms...
July 15, 2017: Chest
https://www.readbyqxmd.com/read/28709421/health-related-quality-of-life-in-patients-with-idiopathic-pulmonary-fibrosis-in-clinical-practice-insights-ipf-registry
#7
Michael Kreuter, Jeff Swigris, David Pittrow, Silke Geier, Jens Klotsche, Antje Prasse, Hubert Wirtz, Dirk Koschel, Stefan Andreas, Martin Claussen, Christian Grohé, Henrike Wilkens, Lars Hagmeyer, Dirk Skowasch, Joachim F Meyer, Joachim Kirschner, Sven Gläser, Felix J F Herth, Tobias Welte, Claus Neurohr, Martin Schwaiblmair, Matthias Held, Thomas Bahmer, Marion Frankenberger, Jürgen Behr
BACKGROUND: The INSIGHTS-IPF registry provides one of the largest data sets of clinical data and self-reported patient related outcomes including health related quality of life (QoL) on patients with idiopathic pulmonary fibrosis (IPF). We aimed to describe associations of various QoL instruments between each other and with patient characteristics at baseline. METHODS: Six hundred twenty-three IPF patients with available QoL data (St George's Respiratory Questionnaire SGRQ, UCSD Shortness-of-Breath Questionnaire SoB, EuroQol visual analogue scale and index EQ-5D, Well-being Index WHO-5) were analysed...
July 14, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28707983/signs-of-gas-trapping-in-normal-lung-density-regions-in-smokers
#8
Sandeep Bodduluri, Joseph M Reinhardt, Eric A Hoffman, John D Newell, Hrudaya Nath, Mark T Dransfield, Surya P Bhatt
RATIONALE: A substantial proportion of subjects without overt airflow obstruction have significant respiratory morbidity and structural abnormalities on computed tomography (CT). Whether regions of the lung that appear normal using traditional CT criteria have mild disease is not known. OBJECTIVE: To identity subthreshold structural disease in normal appearing lung regions in smokers. METHODS: We analyzed 8034 subjects with complete inspiratory and expiratory CT data participating in COPDGene including 103 lifetime non-smokers...
July 14, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28694695/relationship-between-blood-eosinophils-clinical-characteristics-and-mortality-in-patients-with-copd
#9
Maeva Zysman, Gaëtan Deslee, Denis Caillaud, Pascal Chanez, Roger Escamilla, Isabelle Court-Fortune, Pascale Nesme-Meyer, Thierry Perez, Jean-Louis Paillasseur, Christophe Pinet, Gilles Jebrak, Nicolas Roche, Pierre-Régis Burgel
In patients with COPD, there is controversy regarding the association of blood eosinophil (Eos) levels with 1) exacerbation frequency and 2) the effect of inhaled corticosteroids for prevention of exacerbations. To determine whether Eos define subgroups of patients exhibiting attributes of COPD clinical phenotypes, we compared clinical features and mortality rates in COPD patients from the Initiatives BPCO French cohort categorized using different thresholds of blood Eos levels. The following data were collected at inclusion: medical and smoking history, occupational exposures, dyspnea, cough and sputum production, exacerbations in the previous year, history of allergy and asthma, nasal symptoms, body mass index, St George Respiratory Questionnaire (SGRQ) total score, post-bronchodilator spirometry, comorbidities, and medications...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28680567/the-safety-and-tolerability-of-inhaled-treprostinil-in-patients-with-pulmonary-hypertension-and-chronic-obstructive-pulmonary-disease
#10
Abubakr A Bajwa, Adil Shujaat, Minal Patel, Colleen Thomas, Franck Rahaghi, Charles D Burger
The primary aim was to explore the safety and tolerability of inhaled treprostinil when used in patients with pulmonary hypertension (PH) with concomitant chronic obstructive pulmonary disease (COPD). Patients with a diagnosis of pre-capillary PH (defined as pulmonary artery mean pressure of ≥ 25 mmHg and pulmonary artery wedge pressure or left ventricular end diastolic pressure of ≤ 15 mmHg) who were being initiated on inhaled treprostinil and had concomitant COPD (defined as FEV1/FVC ratio ≤ 70% with FEV1 ≥ 40% predicted) were considered for inclusion in this pilot study...
March 2017: Pulmonary Circulation
https://www.readbyqxmd.com/read/28677357/asthma-copd-overlap-shows-favorable-clinical-outcomes-compared-to-pure-copd-in-a-korean-copd-cohort
#11
Hye Jung Park, Min Kwang Byun, Hyung Jung Kim, Chul Min Ahn, Jin Hwa Lee, Kyeong Cheol Shin, Soo Taek Uh, Seung Won Ra, Kwang Ha Yoo, Ki Suck Jung
PURPOSE: Comparisons of the characteristics of chronic obstructive pulmonary disease (COPD) and asthma-COPD overlap syndrome (ACOS) have been the focus of several studies since the diseases were defined by the Global Initiative for Asthma and Global Initiative for Chronic Obstructive Lung Disease guidelines. However, no consensus is available yet. In this study, we aimed to compare the characteristics of asthma-COPD overlap (ACO) and COPD. METHODS: We retrospectively reviewed 1,504 patients with COPD in a Korean COPD Subtype Study cohort...
September 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28674350/depression-is-significantly-associated-with-the-health-status-in-patients-with-idiopathic-pulmonary-fibrosis
#12
Toshiaki Matsuda, Hiroyuki Taniguchi, Masahiko Ando, Yasuhiro Kondoh, Tomoki Kimura, Kensuke Kataoka, Koichi Nishimura, Osamu Nishiyama, Koji Sakamoto, Yoshinori Hasegawa
Objective Depression is reported to be relatively common in idiopathic pulmonary fibrosis (IPF) patients. Thus far, however, whether or not depression independently determines the health-related quality of life (HRQOL) has not been evaluated exclusively in IPF patients. We designed this study to identify independent determinants of the St. George' s Respiratory Questionnaire (SGRQ) score among various factors, including a depression scale, in IPF patients. Methods We retrospectively analyzed consecutive subjects with IPF who completed a systematic evaluation including pulmonary function tests, PaO2 at rest, 6-minute walk test (6MWT), SGRQ, Baseline Dyspnea Index (BDI), and Hospital Anxiety and Depression Scale (HADS)...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28664834/design-of-a-randomised-placebo-controlled-clinical-trial-of-nintedanib-in-patients-with-systemic-sclerosis-associated-interstitial-lung-disease-senscis%C3%A2
#13
Oliver Distler, Kevin K Brown, Jörg H W Distler, Shervin Assassi, Toby M Maher, Vincent Cottin, John Varga, Carl Coeck, Martina Gahlemann, Wiebke Sauter, Hendrik Schmidt, Kristin B Highland
OBJECTIVES: Nintedanib is a tyrosine kinase inhibitor approved for the treatment of idiopathic pulmonary fibrosis (IPF). The pathological pathways involved in fibrogenesis in IPF and interstitial lung disease associated with systemic sclerosis (SSc-ILD) show commonalities; both involve fibroblast activation, myofibroblast accumulation and deposition of extracellular matrix. The SENSCIS™ trial is a randomised, placebo-controlled Phase III trial that will evaluate the efficacy and safety of nintedanib in patients with SSc-ILD (NCT02597933)...
June 29, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28654201/long-acting-beta2-agonists-versus-long-acting-muscarinic-antagonists-in-patients-with-stable-copd-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#14
REVIEW
Wang-Chun Chen, Chi-Hsien Huang, Chau-Chyun Sheu, Inn-Wen Chong, Kuo-An Chu, Yung-Che Chen, Jong-Rung Tsai, Cheng-Hung Lee, Yu-Feng Wei
Several long-acting bronchodilators have been developed and are widely used as first-line treatment in patients with stable chronic obstructive pulmonary disease (COPD). However, the initial choice of therapy is still uncertain. The aim of this study was to examine the clinical efficacy and safety of long-acting muscarinic antagonist (LAMA) and long-acting beta2-agonist (LABA) in patients with stable COPD. We searched several databases and manufacturers' websites to identify relevant randomized clinical trials for meta-analysis...
June 27, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28645458/pulmonary-3-he-magnetic-resonance-imaging-biomarkers-of-regional-airspace-enlargement-in-alpha-1-antitrypsin-deficiency
#15
Eric Lessard, Heather M Young, Anurag Bhalla, Damien Pike, Khadija Sheikh, David G McCormack, Alexei Ouriadov, Grace Parraga
RATIONALE AND OBJECTIVES: Thoracic x-ray computed tomography (CT) and hyperpolarized (3)He magnetic resonance imaging (MRI) provide quantitative measurements of airspace enlargement in patients with emphysema. For patients with panlobular emphysema due to alpha-1 antitrypsin deficiency (AATD), sensitive biomarkers of disease progression and response to therapy have been difficult to develop and exploit, especially those biomarkers that correlate with outcomes like quality of life. Here, our objective was to generate and compare CT and diffusion-weighted inhaled-gas MRI measurements of emphysema including apparent diffusion coefficient (ADC) and MRI-derived mean linear intercept (Lm) in patients with AATD, chronic obstructive pulmonary disease (COPD) ex-smokers, and elderly never-smokers...
June 20, 2017: Academic Radiology
https://www.readbyqxmd.com/read/28631387/umeclidinium-bromide-versus-placebo-for-people-with-chronic-obstructive-pulmonary-disease-copd
#16
REVIEW
Han Ni, Aung Htet, Soe Moe
BACKGROUND: People with chronic obstructive pulmonary disease (COPD) have poor quality of life, reduced survival, and accelerated decline in lung function, especially associated with acute exacerbations, leading to high healthcare costs. Long-acting bronchodilators are the mainstay of treatment for symptomatic improvement, and umeclidinium is one of the new long-acting muscarinic antagonists approved for treatment of patients with stable COPD. OBJECTIVES: To assess the efficacy and safety of umeclidinium bromide versus placebo for people with stable COPD...
June 20, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28623944/the-effect-of-combining-manual-therapy-with-exercise-for-mild-chronic-obstructive-pulmonary-disease-study-protocol-for-a-randomised-controlled-trial
#17
Roger M Engel, Jaxson Wearing, Peter Gonski, Subramanyam Vemulpad
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a major cause of disability and hospital admission. Current management strategies have not been successful in altering the loss of lung function typically seen as the disease progresses. A recent systematic review into the use of spinal manipulative therapy (SMT) in the management of COPD concluded that there was low level evidence to support the view that a combination of SMT and exercise had the potential to improve lung function more than exercise alone in people with moderate to severe COPD...
June 17, 2017: Trials
https://www.readbyqxmd.com/read/28618190/relation-between-upper-limb-muscle-strength-with-exercise-capacity-quality-of-life-and-dyspnea-in-patients-with-severe-chronic-obstructive-pulmonary-disease
#18
Dicle Kaymaz, İpek Çaylı Candemir, Pınar Ergün, Neşe Demir, Filiz Taşdemir, Pervin Demir
INTRODUCTION: In chronic obstructive pulmonary disease (COPD), skeletal muscle weakness is characterized by reduced muscle strength, reduced muscle endurance and the presence of muscle fatigue especially in lower limbs. There has been little research into the upper limb skeletal muscles. OBJECTIVES: In this study, we aimed to investigate the relation of upper limb muscle strength with pulmonary function, exercise capacity, quality of life (QoL) and dyspnea sensation...
June 15, 2017: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/28615931/inhaled-indacaterol-for-the-treatment-of-copd-patients-with-destroyed-lung-by-tuberculosis-and-moderate-to-severe-airflow-limitation-results-from-the-randomized-infinity-study
#19
Cheong-Ju Kim, Hyoung-Kyu Yoon, Myung-Jae Park, Kwang-Ha Yoo, Ki-Suck Jung, Jeong-Woong Park, Seong Yong Lim, Jae Jeong Shim, Yong Chul Lee, Young-Sam Kim, Yeon-Mok Oh, Song Kim, Chul-Gyu Yoo
BACKGROUND AND OBJECTIVE: Pulmonary tuberculosis (TB) is a risk factor for chronic obstructive pulmonary disease (COPD); however, few clinical studies have investigated treatment effectiveness in COPD patients with destroyed lung by TB. The Indacaterol effectiveness in COPD patients with Tuberculosis history (INFINITY) study assessed the efficacy and safety of once-daily inhaled indacaterol 150 µg for the treatment of Korean COPD patients with destroyed lung by TB and moderate-to-severe airflow limitation...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28610668/evaluation-of-the-psychometric-properties-of-the-st-george-s-respiratory-questionnaire-in-patients-with-severe-asthma
#20
Linda M Nelsen, Margaret Vernon, Hector Ortega, Sarah M Cockle, Steven W Yancey, Guy Brusselle, Frank C Albers, Paul W Jones
PURPOSE: Limited data exist on the quantitative validity of the St George's Respiratory Questionnaire (SGRQ) in asthma populations. This study evaluated the psychometric properties of the SGRQ in patients with severe asthma. METHODS: This was a post-hoc analysis of pooled data from MENSA (N = 576; NCT01691508) and SIRIUS (N = 135; NCT01691521), two randomized, placebo controlled trials of mepolizumab in patients with severe asthma. Patients completed the SGRQ at Baseline and Exit (MENSA Week 32; SIRIUS Week 24)...
July 2017: Respiratory Medicine
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