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https://www.readbyqxmd.com/read/29457316/assessment-of-pulmonary-structure-function-relationships-in-young-children-and-adolescents-with-cystic-fibrosis-by-multivolume-proton-mri-and-ct
#1
Francesca Pennati, David J Roach, John P Clancy, Alan S Brody, Robert J Fleck, Andrea Aliverti, Jason C Woods
BACKGROUND: Lung disease is the most frequent cause of morbidity and mortality in patients with cystic fibrosis (CF), and there is a shortage of sensitive biomarkers able to regionally monitor disease progression and to assess early responses to therapy. PURPOSE: To determine the feasibility of noncontrast-enhanced multivolume MRI, which assesses intensity changes between expiratory and inspiratory breath-hold images, to detect and quantify regional ventilation abnormalities in CF lung disease, with a focus on the structure-function relationship...
February 19, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29456738/recurrence-of-adenoid-cystic-carcinoma-of-the-trachea-treated-with-radical-radiotherapy-a-case-report
#2
Konrad Pawlewicz, Zbigniew Szutkowski, Andrzej Kawecki
Adenoid cystic carcinoma (ACC) of the trachea is a relatively rare tumor among thoracic diseases. The present study reports the case of a 23-year-old woman with ACC of the trachea who underwent surgical resection of the tumor in The National Institute of Tuberculosis and Lung Diseases (Warsaw, Poland). Histopathological examination revealed that the tumor was not completely resected (R2 resection) and strict observation of the patient was therefore prescribed. After ~9 years of follow-up, clinical and histopathological tumor progression was confirmed and the patient was referred to the Centre of Oncology in Warsaw...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29456361/upper-cervical-bronchogenic-cyst-a-rare-condition-at-a-rare-location
#3
Ranjeet Kumar Jha, Chandan B Mohanty, Chandrashekhar E Deopujari, Salman Tehran Shaikh
Intraspinal bronchogenic cyst (SBC) is a rare but important cause of spinal cord compression, commonly seen in the cervicothoracic spine. We report a case of a 43-year-old male, presenting with complaints of neck pain, radiating to right shoulder, with numbness of right hand and fingers. Magnetic resonance imaging of the cervical spine revealed an intradural extramedullary, ventral cystic lesion extending from C2 to C4 vertebral levels. Complete surgical excision was performed, and the patient had a complete relief of symptoms postoperatively...
January 2018: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/29454860/velocity-landscape-correlation-resolves-multiple-flowing-protein-populations-from-fluorescence-image-time-series
#4
Elvis Pandžić, Asmahan Abu-Arish, Renee W Whan, John W Hanrahan, Paul W Wiseman
Molecular, vesicular and organellar flows are of fundamental importance for the delivery of nutrients and essential components used in cellular functions such as motility and division. With recent advances in fluorescence/super-resolution microscopy modalities we can resolve the movements of these objects at higher spatio-temporal resolutions and with better sensitivity. Previously, spatio-temporal image correlation spectroscopy has been applied to map molecular flows by correlation analysis of fluorescence fluctuations in image series...
February 15, 2018: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/29450207/fixation-of-traumatic-chondral-only-fragments-of-the-knee-in-pediatric-and-adolescent-athletes-a-retrospective-multicenter-report
#5
Peter D Fabricant, Yi-Meng Yen, Dennis E Kramer, Mininder S Kocher, Lyle J Micheli, J Todd R Lawrence, Theodore J Ganley, Benton E Heyworth
Background: While traditional biological principles have suggested that fragments consisting of cartilage alone cannot be reaffixed to bone with expectable long-term healing, case reports of successful healing after fixation in younger patients indicate that this concept remains incompletely explored. Purpose: To evaluate the presenting features, techniques, healing rates, and clinical and radiological results in a cohort of pediatric and adolescent athletes who underwent fixation of traumatic chondral-only fragments in the knee...
February 2018: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29449283/clinical-validation-of-a-predictive-model-for-the-presence-of-cervical-lymph-node-metastasis-in-papillary-thyroid-cancer
#6
N U Patel, K E Lind, K McKinney, T J Clark, S S Pokharel, J M Meier, E R Stamm, K Garg, B Haugen
BACKGROUND AND PURPOSE: Ultrasound is a standard technique to detect lymph node metastasis in papillary thyroid cancer. Cystic changes and microcalcifications are the most specific features of metastasis, but with low sensitivity. This prospective study compared the diagnostic accuracy of a predictive model for sonographic evaluation of lymph nodes relative to the radiologist's standard assessment in detecting papillary thyroid cancer metastasis in patients after thyroidectomy. MATERIALS AND METHODS: Cervical lymph node sonographic images were reported by a radiologist (R method) per standard practice...
February 15, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29444709/mucinous-cystic-neoplasm-of-the-liver-with-extrahepatic-growth-presenting-with-ascending-cholangitis-diagnosed-by-endoscopic-ultrasound-features-a-case-report
#7
Tanawat Pattarapuntakul, Bancha Ovartlarnporn, Jaksin Sottisuporn
BACKGROUND: Mucinous cystic neoplasm of the liver with extrahepatic growth is a rare benign epithelial neoplasm of the biliary system that presents with a mass effect or is incidentally found on imaging. The tumor affects mostly the common hepatic duct, which is difficult to diagnose preoperatively by radiology, endoscopy, or cystic fluid analysis. Endoscopic ultrasound is a noninvasive tool for the evaluation of features of a cystic lesion and the extent of disease. Optimal treatment is complete tumor resection...
February 15, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29443754/multiple-extra-articular-synovial-cysts-accompanied-by-rheumatoid-arthritis-in-the-bilateral-elbow-joints-a-case-report
#8
Jingfeng Zhang, Junli Wang, Xiongwei Mao, Zhengang Li
RATIONALE: Synovial cysts are well known in rheumatoid arthritis (RA), and most common in the popliteal fossa. They may produce lots of local symptoms and complaints, which may present initially as an unrelated clinical condition. Few studies have reported multiple extra-articular synovial cysts (MESCs) in the RA patients. Early diagnosis is crucial for patient treatment. PATIENT CONCERNS: A 50-year-old man without any special clinical histories found a soya bean size bump at the left elbow medially, then multiple lumps were found at bilateral elbows and gradually increasing...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29443360/swept-source-oct-angiography-of-full-thickness-macular-holes-appearance-and-artifacts
#9
Zofia Michalewska, Jerzy Nawrocki
BACKGROUND AND OBJECTIVE: To evaluate swept-source optical coherence tomography angiography (SS-OCTA) images in full-thickness macular holes (FTMHs). PATIENTS AND METHODS: SS-OCTA of FTMHs was performed before or after surgery. Vitrectomy with the temporal inverted internal limiting membrane flap technique was used. The authors measured the diameter and area of the foveal avascular zone (FAZ) in superficial and deep retina vasculature. RESULTS: In 88 patients, two artifact types were observed...
February 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/29439906/dermoid-cysts-of-the-conus-medullaris-clinical-review-case-series-and-management-strategies
#10
Salah G Aoun, Mary Ashley Liu, Megan Still, Tarek Y El Ahmadieh, Mazin Al Tamimi, Wayne Gluf
BACKGROUND: The management of dermoid cysts can be tedious as they have a tendency to recur, and respond poorly to chemotherapy and radiation. Management is especially difficult for tumors involving highly eloquent areas such as the conus medullaris. OBJECTIVE: We aim to provide a summary of the pathology, clinical presentation, and operative management strategies of dermoid cysts involving the conus medullaris. METHODS: Two clinical cases of dermoid cysts of the conus are presented, as well as a commented surgical video...
February 10, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29437060/degenerative-subtalar-joints-complicated-by-medial-plantar-intraneural-cysts-cutting-the-cystic-articular-branch-prevents-recurrence
#11
P Laumonerie, F Lapègue, N Reina, M Tibbo, M Rongières, M Faruch, P Mansat
AIMS: The pathogenesis of intraneural ganglion cysts is controversial. Recent reports in the literature described medial plantar intraneural ganglion cysts (mIGC) with articular branches to subtalar joints. The aim of the current study was to provide further support for the principles underlying the articular theory, and to explain the successes and failures of treatment of mICGs. PATIENTS AND METHODS: Between 2006 and 2017, five patients with five mICGs were retrospectively reviewed...
February 2018: Bone & Joint Journal
https://www.readbyqxmd.com/read/29436846/effect-of-dimethyl-fumarate-on-renal-disease-progression-in-a-genetic-ortholog-of-nephronophthisis
#12
Oliver Oey, Padmashree Rao, Magdalena Luciuk, Carly Mannix, Natasha M Rogers, Priyanka Sagar, Annette Wong, Gopala Rangan
Dimethyl fumarate is an FDA-approved oral immunomodulatory drug with anti-inflammatory properties that induces the upregulation of the anti-oxidant transcription factor, nuclear factor erythroid-derived factor 2. The aim of this study was to determine the efficacy of dimethyl fumarate on interstitial inflammation and renal cyst growth in a preclinical model of nephronophthisis. Four-week-old female Lewis polycystic kidney disease (a genetic ortholog of human nephronophthisis-9) rats received vehicle (V), 10 mg/kg (D10) or 30 mg/kg (D30) ( n = 8-9 each) dimethyl fumarate in drinking water for eight weeks...
January 1, 2018: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29436307/cancers-of-the-major-salivary-gland
#13
Eugene Son, Aru Panwar, Charles H Mosher, Daniel Lydiatt
Salivary gland malignancies are rare tumors that comprise multiple histologic entities with diverse clinical behavior. Mucoepidermoid carcinoma is the most frequent primary salivary malignancy, followed by adenoid cystic and acinic cell carcinoma. Although most salivary malignancies are asymptomatic, presentation with a rapidly enlarging mass may be accompanied by pain, functional neurologic deficits, soft-tissue invasion, or nodal enlargement. Assessment of clinical behavior and physical exam greatly contributes to diagnostic workup...
February 2018: Journal of Oncology Practice
https://www.readbyqxmd.com/read/29435299/multilocular-cystic-renal-cell-carcinoma-a-case-report-and-review-of-the-literature
#14
Jia Hu, Lu Jin, Yifan Li, Tao He, Jiaju Liu, Bentao Shi, Shangqi Yang, Yaoting Gui, Xiangming Mao, Yongqing Lai, Liangchao Ni
Multilocular cystic renal cell carcinoma (MCRCC), which exhibits low-stage and low-grade characteristics, is a special type of RCC. MCRCC is extremely rare and generally develops at ages >50 years. We herein report a case of MCRCC in a 28-year-old man, which, to the best of our knowledge, is the youngest case reported worldwide to date. The patient presented with irritative bladder symptoms for 1 year. Dynamic enhanced computed tomography (CT) imaging revealed a mass with inhomogeneous enhancement in the left kidney, with a rich blood supply...
February 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29427441/the-utility-of-the-ankle-spect-ct-scan-to-predict-functional-and-clinical-outcomes-in-supramalleolar-osteotomy-patients
#15
Christopher E Gross, William Barfield, Christine Schweizer, Helmut Rasch, Michael T Hirschmann, Beat Hintermann, Markus Knupp
Combined single-photon emission computed tomography and conventional computed tomography (SPECT/CT) is a hybrid imaging modality that shows a combination of metabolic and structural information about the ankle, including arthritis. We hypothesize that uptake in specific locations within the ankle joint can be associated with both clinical outcomes and may help predict which patients will have a successful SMO. Eighty-five pre-operative SMO patients with varus (37), valgus (41), or neutral (7) alignment of the hindfoot were assessed using SPECT/CT...
February 10, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29425276/giant-cell-tumor-of-bone-in-patients-55-years-and-older-a-study-of-34-patients
#16
Cory J Broehm, Carrie Y Inwards, Alyaa Al-Ibraheemi, Doris E Wenger, Sarah M Jenkins, Long Jin, Andre M Oliveira, Riyam T Zreik, Jodi M Carter, Jennifer M Boland, Karen J Fritchie
Objectives: Most giant cell tumors of bone (GCTs) occur in patients aged 20 to 40 years. We analyzed features of GCT in patients 55 years or older. Methods: GCTs were examined for fibrosis, matrix, cystic change, histiocytes, mitoses, and necrosis. Clinical/radiologic data were collected. Results: Thirty-four (5%) of 710 GCTs occurred in patients older than 55 years (14/20 male/female; 56-83 years) in long bones (n = 24), vertebrae (n = 6), pelvis (n = 3), and metacarpal (n = 1)...
February 7, 2018: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29415686/prenatal-and-accurate-perinatal-diagnosis-of-type-2-h-or-ductular-duplicate-gallbladder
#17
Umberto Maggi, Giorgio Farris, Alessandra Carnevali, Irene Borzani, Paola Clerici, Massimo Agosti, Giorgio Rossi, Ernesto Leva
BACKGROUND: Double gallbladder is a rare biliary anomaly. Perinatal diagnosis of the disorder has been reported in only 6 cases, and in 5 of them the diagnosis was based on ultrasound imaging only. However, the ultrasound technique alone does not provide a sufficiently precise description of cystic ducts and biliary anatomy, an information that is crucial for a correct classification and for a possible future surgery. CASE PRESENTATION: At 21 weeks of gestational age of an uneventful pregnancy in a 38 year old primipara mother, a routine ultrasound screening detected a biliary anomaly in the fetus suggestive of a double gallbladder...
February 7, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29412515/l-methionine-anti-biofilm-activity-against-pseudomonas-aeruginosa-is-enhanced-by-the-cystic-fibrosis-transmembrane-conductance-regulator-potentiator-ivacaftor
#18
Do-Yeon Cho, Dong-Jin Lim, Calvin Mackey, Christopher G Weeks, Jaime A Peña Garcia, Daniel Skinner, Jessica W Grayson, Harrison S Hill, David K Alexander, Shaoyan Zhang, Bradford A Woodworth
BACKGROUND: Biofilms may contribute to refractory chronic rhinosinusitis (CRS), as they lead to antibiotic resistance and failure of effective clinical treatment. l-Methionine is an amino acid with reported biofilm-inhibiting properties. Ivacaftor is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator with mild antimicrobial activity via inhibition of bacterial DNA gyrase and topoisomerase IV. The objective of this study was to evaluate whether co-treatment with ivacaftor and l-methionine can reduce the formation of Pseudomonas aeruginosa biofilms...
February 7, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29411052/-spinal-cysts-diagnostic-workup-and-therapy
#19
REVIEW
A Simgen
CLINICAL ISSUE: Spinal cysts can be classified as meningeal, not meningeal, and tumor-associated cysts. Due to the widespread availability of high-resolution computed tomography and magnet resonance imaging, spinal cysts can be detected with high sensitivity these days. Concerning the variety of potential cystic differential diagnoses, a precise classification is difficult and can often only be realized after surgical inspection or histological examination. PRACTICAL RECOMMENDATIONS: Spinal cysts are generally incidental findings during a routine diagnostic workup and need no further therapy...
February 2018: Der Radiologe
https://www.readbyqxmd.com/read/29410694/multiparametric-ultrasound-findings-in-a-patient-with-polyorchidism
#20
Vasileios Rafailidis, Mary Arvaniti, Dimitrios Rafailidis, Dimitrios Sfoungaris
Polyorchidism is a rare condition usually incidentally discovered in young patients investigated with ultrasound for unrelated reasons. It is characterized by the presence of unilateral or, rarely, bilateral supernumerary testes which, depending on the type of polyorchidism, may have their own epididymis and vas deferens. Ultrasound, including B-mode and color Doppler technique, represents the primary imaging modality for the evaluation of scrotal diseases, including the characterization of supernumerary testes, which normally appear identical to the ipsilateral testicular parenchyma on every ultrasonographic technique performed...
August 2017: Ultrasound: Journal of the British Medical Ultrasound Society
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