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ferrous sulphate

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https://www.readbyqxmd.com/read/28800117/iron-fortification-of-lentil-lens-culinaris-medik-to-address-iron-deficiency
#1
Rajib Podder, Bunyamin Tar'an, Robert T Tyler, Carol J Henry, Diane M DellaValle, Albert Vandenberg
Iron (Fe) deficiency is a major human health concern in areas of the world in which diets are often Fe deficient. In the current study, we aimed to identify appropriate methods and optimal dosage for Fe fortification of lentil (Lens culinaris Medik.) dal with FeSO₄·7H₂O (ferrous sulphate hepta-hydrate), NaFeEDTA (ethylenediaminetetraacetic acid iron (III) sodium salt) and FeSO₄·H₂O (ferrous sulphate mono-hydrate). We used a colorimetric method to determine the appearance of the dal fortified with fortificants at different Fe concentrations and under different storage conditions...
August 11, 2017: Nutrients
https://www.readbyqxmd.com/read/28763945/oxidative-stability-of-iron-fortified-goat-and-cow-milk-and-their-peptide-isolates
#2
A Smialowska, L Matia-Merino, A J Carr
The oxidation potential of iron fortified goat and cow milks and casein phosphopeptides obtained from each species of milk was determined using malondialdehyde as an oxidation product marker. There was a reduction in oxidation when iron was 'bound' to milk or peptides compared to free ferrous sulphate in solution. However, goat milk produced significantly lower amounts of malondialdehyde of 0.46±0.04μgMDA/ml after 3days at 30°C compared to the blank of 1.25±0.16μgMDA/ml. The goat peptides produced non-significantly different levels of malondialdehyde compared to the blank containing no ferrous sulphate...
December 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28762362/prevalence-and-pattern-of-potential-drug-drug-interactions-among-chronic-kidney-disease-patients-in-south-western-nigeria
#3
J Fasipe Olumuyiwa, A Akinbodewa Akinwumi, O Adejumo Ademola, B Akawa Oluwole, E Okaka Ibiene
BACKGROUND: Management of chronic kidney disease (CKD) patients often requires the use of multiple drugs due to a high number of cardiovascular risk factors and complications associated with the disease. Multiple drugs predispose to potential drug-drug interactions (DDIs) which may be associated with increased morbidity, mortality, length of hospital stay and health-care cost. OBJECTIVES: This study determined the prevalence and pattern of potential DDIs among CKD patients attending Kidney Care Centre, in Ondo City, Nigeria...
April 2017: Nigerian Postgraduate Medical Journal
https://www.readbyqxmd.com/read/28755971/efficacy-of-standardized-extract-of-hibiscus-sabdariffa-l-malvaceae-in-improving-iron-status-of-adults-in-malaria-endemic-area-a-randomized-controlled-trial
#4
Emanuel L Peter, Susan F Rumisha, Kijakazi O Mashoto, Omary Ms Minzi, Sayoki Mfinanga
ETHNOPHARMACOLOGICAL RELEVANCE: Indigenous community of Mkuranga district have been using aqueous extract of H. sabdariffa L. for treating anemia. However, there have been neither safety nor efficacy studies to validate this medicinal product in anemia. AIM: The purpose of this study was to establish efficacy and safety of standardized aqueous extract of H. sabdariffa L. in anemic adults. MATERIALS AND METHODS: This was a randomized controlled clinical trial in which 130 adults' men and women aged 18-50 years were involved after meeting the inclusion criteria...
July 26, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28738702/combined-effects-of-whey-protein-hydrolysates-and-probiotics-on-oxidative-stress-induced-by-an-iron-overloaded-diet-in-rats
#5
Eunju Park, Hyun-Dong Paik, Seung-Min Lee
Whey proteins possess antioxidant properties, and probiotics have various health-promoting effects. We investigated the effects of whey protein hydrolysates (WPHs) and probiotics in rats exposed to oxidative stress induced by iron-overload diet (IOL). Rats were divided into control (CTRL), IOL (0.2% ferrous sulphate), WPH (10%), probiotic (PB) mixture (Lactococcus lactis NK34 and B. polyfermenticus SCD), and WPH + PB group for 6 weeks. Average leukocytes and colonocytes tail moments were increased in IOL compared to CTRL but decreased in other groups...
July 25, 2017: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/28728456/quillaja-saponaria-bark-saponin-protects-wistar-rats-against-ferrous-sulphate-induced-oxidative-and-inflammatory-liver-damage
#6
Mustafa Ahmed Abdel-Reheim, Basim Anwar Shehata Messiha, Ali Ahmed Abo-Saif
CONTEXT: Saponins from different sources are historically reported in Chinese medicine to possess many beneficial effects. However, insufficient experimental data are available regarding the hepatoprotective potential of Quillaja bark saponin. OBJECTIVE: The protective effect of Quillaja saponaria Molina (Quillajaceae) bark triterpenoid saponin against iron-induced hepatotoxicity is compared to the standard N-acetylcysteine in adult male Wistar rats. MATERIALS AND METHODS: Animals were divided into (six) groups, namely a normal control, an N-acetylcysteine control (300 mg/kg/day, p...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28724166/iron-pharmacokinetics-in-women-with-iron-deficiency-anaemia-following-a-single-oral-dose-of-a-novel-formulation-of-tardyferon-prolonged-release-ferrous-sulphate
#7
Andrew Leary, Laurence Barthe, Thierry Clavel, Claudie Sanchez, Zahida Issiakhem, Bruno Paillard, Jean-Marc Edmond
Numerous iron-containing preparations are available on the market; these vary in dosage, salt, chemical state of iron (ferric or ferrous) and in the iron delivery process (immediate or prolonged-release). Tardyferon® is a prolonged-release tablet containing 80 mg ferrous sulphate. The formulation has recently been modified; changes to the excipients which constitute the inert formulation matrix have allowed a decrease in tablet size for easier swallowing. The aim of this multicenter open-label study was to characterize the serum pharmacokinetics of iron in non-pregnant women aged 23-45 years with iron deficiency anaemia (IDA) following single oral administration of 160 mg Tardyferon® under fasting conditions...
July 19, 2017: Drug Research
https://www.readbyqxmd.com/read/28689123/pyrolysis-of-attapulgite-clay-blended-with-yak-dung-enhances-pasture-growth-and-soil-health-characterization-and-initial-field-trials
#8
Muhammad Khalid Rafiq, Stephen D Joseph, Fei Li, Yanfu Bai, Zhanhuan Shang, Aditya Rawal, James M Hook, Paul R Munroe, Scott Donne, Sara Taherymoosavi, David R G Mitchell, Ben Pace, Mohanad Mohammed, Joseph Horvat, Christopher E Marjo, Avital Wagner, Yanlong Wang, Jun Ye, Rui-Jun Long
Recent studies have shown that the pyrolysis of biomass combined with clay can result in both lower cost and increase in plant yields. One of the major sources of nutrients for pasture growth, as well as fuel and building materials in Tibet is yak dung. This paper reports on the initial field testing in a pasture setting in Tibet using yak dung, biochar, and attapulgite clay/yak dung biochars produced at ratios of 10/90 and 50/50 clay to dung. We found that the treatment with attapulgite clay/yak dung (50/50) biochar resulted in the highest pasture yields and grass nutrition quality...
July 19, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28669072/free-and-immobilized-aspergillus-oryzae-sbs50-producing-protease-resistant-and-thermostable-phytase
#9
Sapna, Bijender Singh
Optimization for enhanced phytase production by Aspergillus oryzae SBS50 in submerged fermentation was investigated using Taguchi design. In first step design, starch, beef extract, magnesium sulphate, ferrous sulphate and Tween 80 were identified as significant factors affecting phytase production. These significant factors were further optimized at four different levels using a second Taguchi design and were observed that 1% starch, 2% beef extact, 3% Tween 80, 0.1% magnesium sulphate and 0.225% ferrous sulphate supported maximum phytase production (47,432 U/L)...
July 2017: 3 Biotech
https://www.readbyqxmd.com/read/28667040/mitochondrial-iron-accumulation-in-parietal-and-chief-cells-in-iron-pill-gastritis-following-billroth-ii-gastrectomy-case-report-including-electron-microscopic-examination
#10
Khurram Shafique, James L Araujo, Rajesh Veluvolu, Nicholas Cassai, Fidelina Desoto-Lapaix, Matthew R Pincus, Rosemary L Wieczorek
Iron pill gastritis has been shown to be associated with superficial gastric erosion and deposition of iron in lamina propria and gastric antral glands. However, iron absorption in gastric parietal and chief cells is rare. We present a case of a 62-year-old man with iron deficiency anemia. His past medical history is significant for Billroth II surgery. His medications include ferrous sulphate 325mg. Esophagogastroduodenoscopy showed diffuse circumferential abnormal mucosa at the gastro-jejunal anastomosis...
May 2017: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/28427623/degradation-of-reactive-blue-13-using-hydrodynamic-cavitation-effect-of-geometrical-parameters-and-different-oxidizing-additives
#11
Sunil Rajoriya, Swapnil Bargole, Virendra Kumar Saharan
Decolorization of reactive blue 13 (RB13), a sulphonated azo dye, was investigated using hydrodynamic cavitation (HC). The aim of research article is to check the influence of geometrical parameters (total flow area, the ratio of throat perimeter to its cross-sectional area, throat shape and size, etc.) and configuration of the cavitating devices on decolorization of RB13 in aqueous solution. For this purpose, eight cavitating devices i.e. Circular and slit venturi, and six orifice plates having different flow area and perimeter were used in the present work...
July 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28406909/sustained-effectiveness-of-weekly-iron-folic-acid-supplementation-and-regular-deworming-over-6-years-in-women-in-rural-vietnam
#12
Gerard J Casey, Ta T Tinh, Nong T Tien, Sarah Hanieh, Luca T Cavalli-Sforza, Antonio Montresor, Beverley-Ann Biggs
BACKGROUND: Weekly iron-folic acid (IFA) supplementation and regular deworming is effective for the prevention of iron deficiency and anaemia in women of child-bearing age. Between 2006 and 2013, a program of weekly IFA and biannual deworming was implemented in Yen Bai province, Vietnam. In this study we aimed to determine the effectiveness of the program in reducing anaemia and the prevalence of hookworm infection after 72 months (six years). METHODS: This prospective cohort study followed up a cohort of 389 women of child-bearing age from baseline until six years after the introduction of the weekly IFA (one tablet containing 200 mg ferrous sulphate, 0...
April 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28335378/bioavailability-of-microencapsulated-iron-from-fortified-bread-assessed-using-piglet-model
#13
Malgorzata A Bryszewska, Luca Laghi, Augusta Zannoni, Andrea Gianotti, Francesca Barone, Danielle L Taneyo Saa, Maria L Bacci, Domenico Ventrella, Monica Forni
The aim of this study was to investigate the influence of oral iron supplementation, in the form of fortified breads, on the growth performance, health, iron status parameters, and fecal metabolome of anemic piglets. A study was conducted on 24 hybrid (Large White × Landrace × Duroc) piglets. From day 44, the post-natal 12 piglets were supplemented with 100 g of one of two experimental breads, each fortified with 21 mg of ferrous sulphate, either encapsulated or not. After one week of oral supplementation, hematological parameters (hematocrit value, hemoglobin, and red blood cells) showed statistically significant differences (p ≤ 0...
March 13, 2017: Nutrients
https://www.readbyqxmd.com/read/28228777/natural-mineral-waters-chemical-characteristics-and-health-effects
#14
REVIEW
Sara Quattrini, Barbara Pampaloni, Maria Luisa Brandi
Water contributes significantly to health and a daily intake of 1.5 to 2 liters of water should be guaranteed, because a good hydration is essential to maintain the body water equilibrium, although needs may vary among people. However, worldwide population is far from the Recommended Allowance for water intake. Among the waters for human uses, there are 'waters (treated or not), intended for drinking, used for the food and beverages preparation or for other domestic purposes' and natural mineral waters, that are 'originated from an aquifer or underground reservoir, spring from one or more natural or bore sources and have specific hygienic features and, eventually, healthy properties'...
September 2016: Clinical Cases in Mineral and Bone Metabolism
https://www.readbyqxmd.com/read/28209442/the-maturation-state-of-the-auditory-nerve-and-brainstem-in-rats-exposed-to-lead-acetate-and-supplemented-with-ferrous-sulfate
#15
Fernanda Zucki, Thais C Morata, Josilene L Duarte, Maria Cecília F Ferreira, Manoel H Salgado, Kátia F Alvarenga
INTRODUCTION: The literature has reported the association between lead and auditory effects, based on clinical and experimental studies. However, there is no consensus regarding the effects of lead in the auditory system, or its correlation with the concentration of the metal in the blood. OBJECTIVE: To investigate the maturation state of the auditory system, specifically the auditory nerve and brainstem, in rats exposed to lead acetate and supplemented with ferrous sulfate...
January 23, 2017: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28102948/use-of-parallel-plate-ionization-chambers-in-reference-dosimetry-of-novac-and-liac-%C3%A2-mobile-electron-linear-accelerators-for-intraoperative-radiotherapy-a-multi-center-survey
#16
Paolo Scalchi, Alessia Ciccotelli, Giuseppe Felici, Assunta Petrucci, Raffaella Massafra, Valeria Piazzi, Paola D'Avenia, Francesca Cavagnetto, Federica Cattani, Raffaella Romagnoli, Antonella Soriani
PURPOSE: LIAC(®) and NOVAC are two mobile linear accelerators dedicated to intraoperative radiation therapy (IORT), generating electron beams in the energy range of 3-12 MeV. Due to high dose-per-pulse (up to 70 mGy per pulse), in 2003 the Italian National Institute of Health (ISS) stated that "for the measure of dose to water in reference conditions, ionization chambers cannot be employed and no published dosimetry protocol can be used". As a consequence, ferrous sulphate (or, alternatively alanine) dosimetry was recommended...
January 2017: Medical Physics
https://www.readbyqxmd.com/read/28092401/randomized-clinical-trial-of-preoperative-oral-versus-intravenous-iron-in-anaemic-patients-with-colorectal-cancer
#17
B D Keeler, J A Simpson, O Ng, H Padmanabhan, M J Brookes, A G Acheson
BACKGROUND: Treatment of preoperative anaemia is recommended as part of patient blood management, aiming to minimize perioperative allogeneic red blood cell transfusion. No clear evidence exists outlining which treatment modality should be used in patients with colorectal cancer. The study aimed to compare the efficacy of preoperative intravenous and oral iron in reducing blood transfusion use in anaemic patients undergoing elective colorectal cancer surgery. METHODS: Anaemic patients with non-metastatic colorectal adenocarcinoma were recruited at least 2 weeks before surgery and randomized to receive oral (ferrous sulphate) or intravenous (ferric carboxymaltose) iron...
February 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28054602/identification-of-guanosine-5-diphosphate-as-potential-iron-mobilizer-preventing-the-hepcidin-ferroportin-interaction-and-modulating-the-interleukin-6-stat-3-pathway
#18
Stanzin Angmo, Neha Tripathi, Sheenu Abbat, Shailesh Sharma, Shelley Sardul Singh, Avishek Halder, Kamalendra Yadav, Geeta Shukla, Rajat Sandhir, Vikas Rishi, Prasad V Bharatam, Hariom Yadav, Nitin Kumar Singhal
Hepcidin, a peptide hormone, is a key regulator in mammalian iron homeostasis. Increased level of hepcidin due to inflammatory conditions stimulates the ferroportin (FPN) transporter internalization, impairing the iron absorption; clinically manifested as anemia of inflammation (AI). Inhibiting hepcidin-mediated FPN degradation is proposed as an important strategy to combat AI. A systematic approach involving in silico, in vitro, ex vivo and in vivo studies is employed to identify hepcidin-binding agents. The virtual screening of 68,752 natural compounds via molecular docking resulted into identification of guanosine 5'-diphosphate (GDP) as a promising hepcidin-binding agent...
January 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/27932449/oral-iron-treatment-response-and-predictors-in-anaemic-adolescents-and-adults-with-ibd-a-prospective-controlled-open-label-trial
#19
David S Rampton, James R Goodhand, Neerav M Joshi, Abu-Bakarr Karim, Yasmine Koodun, Farah M Barakat, Lucia Macken, Douglas G Ward, Tariq H Iqbal, Jenny Epstein, John M Fell, Ian R Sanderson
Background: Because of previous concerns about the efficacy and safety of oral iron for treating iron deficiency anaemia in inflammatory bowel disease [IBD], particularly in young people, we compared the effects of ferrous sulphate on haemoglobin response, disease activity and psychometric scores in adolescents and adults with IBD. We also assessed the relation of baseline serum hepcidin to haemoglobin response. Methods: We undertook a prospective, open-label, 6-week non-inferiority trial of the effects of ferrous sulphate 200 mg twice daily on haemoglobin, iron status, hepcidin, disease activity (Harvey-Bradshaw Index, Simple Colitis Clinical Activity Index, C-reactive protein [CRP]), faecal calprotectin and psychometric scores in 45 adolescents [age 13-18 years] and 43 adults [>18 years]...
June 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/27808258/significant-glial-alterations-in-response-to-iron-loading-in-a-novel-organotypic-hippocampal-slice-culture-model
#20
Sinead Healy, Jill McMahon, Peter Owens, Una FitzGerald
Aberrant iron deposition in the brain is associated with neurodegenerative disorders including Multiple Sclerosis, Alzheimer's disease and Parkinson's disease. To study the collective response to iron loading, we have used hippocampal organotypic slices as a platform to develop a novel ex vivo model of iron accumulation. We demonstrated differential uptake and toxicity of iron after 12 h exposure to 10 μM ferrous ammonium sulphate, ferric citrate or ferrocene. Having established the supremacy of ferrocene in this model, the cultures were then loaded with 0...
November 3, 2016: Scientific Reports
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