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intramuscular injection of vitamin k

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https://www.readbyqxmd.com/read/27774418/nephroprotective-effect-of-ethanolic-extract-of-azima-tetracantha-root-in-glycerol-induced-acute-renal-failure-in-wistar-albino-rats
#1
Venugopala Rao Konda, Ruckmani Arunachalam, Madhavi Eerike, Ramesh Rao K, Arun Kumar Radhakrishnan, Lakshmipathy Prabhu Raghuraman, Vinayak Meti, Sobita Devi
The gravity of the impact of renal failure on human health is well known and as there is no specific pharmacotherapy for renal failure, the current study was undertaken to evaluate the effect of root extract of Azima tetracantha, an ancient medicinal plant used in Siddha and Ayurvedhic systems of medicine. The experiment was done in glycerol-induced acute renal failure in Wistar albino rats. Thirty rats were divided into five groups. Group 1 was given normal saline (10 ml/kg) per oral, group 2 with single dose of hypertonic glycerol (8 ml/kg) by intramuscular injection into the hind limbs, group 3 with glycerol and ethanolic extract of A...
October 2016: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/27665006/effects-of-dietary-vitamin-e-type-on-the-growth-performance-and-antioxidant-capacity-in-cyclophosphamide-immunosuppressed-broilers
#2
K Cheng, Z H Song, X C Zheng, H Zhang, J F Zhang, L L Zhang, Y M Zhou, T Wang
Reactive oxygen species and free radicals play multiple roles in some immune-pathological events. Vitamin E, as a very potent antioxidant, perhaps deceases the potentially negative effects of such oxidative stress to prevent immune-pathological damage to broilers. Therefore, the current study investigated the effects of dietary natural (D-α-tocopherol) and synthetic (DL-α-tocopherol acetate) vitamin E on the growth performance and antioxidant capacity in cyclophosphamide (CY) immunosuppressed broilers. 192 one-day-old male Arbor Acre broilers were randomly distributed into 4 groups: 1) non-CY-challenged control; 2) CY-challenged control; 3) CY-challenged group+20 IU DL-α-tocopherol acetate per kg feed; and 4) CY-challenged group+20 IU D-α-tocopherol per kg feed...
September 24, 2016: Poultry Science
https://www.readbyqxmd.com/read/27146501/comparison-between-different-intramuscular-vitamin-b12-supplementation-regimes-a-retrospective-matched-cohort-study
#3
H J M Smelt, S Pouwels, M Said, K A Berghuis, A K Boer, J F Smulders
BACKGROUND: The incidence of vitamin B12 deficiency after bariatric surgery can range from 26 to 70 %. There is no consensus on optimal vitamin B12 supplementation in postbariatric patients. The objective of this study was to compare three different regimes. METHODS: In this retrospective matched cohort study, we included 63 patients with methylmalonic acid (MMA) levels ≥300 nmol/L. Group A (n = 21) received 6 intramuscular (im) vitamin B12 injections including a loading dose, group B (n = 21) received 3 im vitamin B12 injections without loading dose and group C (n = 21) received no im vitamin B12 injections...
May 5, 2016: Obesity Surgery
https://www.readbyqxmd.com/read/27050049/prevention-of-vitamin-k-deficiency-bleeding-in-newborn-infants-a-position-paper-by-the-espghan-committee-on-nutrition
#4
Walter A Mihatsch, Christian Braegger, Jiri Bronsky, Cristina Campoy, Magnus Domellöf, Mary Fewtrell, Nataša F Mis, Iva Hojsak, Jessie Hulst, Flavia Indrio, Alexandre Lapillonne, Christian Mlgaard, Nicholas Embleton, Johannes van Goudoever
Vitamin K deficiency bleeding (VKDB) due to physiologically low vitamin K plasma concentrations is a serious risk for newborn and young infants and can be largely prevented by adequate vitamin K supplementation. The aim of this position paper is to define the condition, describe the prevalence, discuss current prophylaxis practices and outcomes, and to provide recommendations for the prevention of VKDB in healthy term newborns and infants. All newborn infants should receive vitamin K prophylaxis and the date, dose, and mode of administration should be documented...
July 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/26530713/improving-bariatric-patient-aftercare-outcome-by-improved-detection-of-a-functional-vitamin-b12-deficiency
#5
H J M Smelt, J F Smulders, M Said, S W Nienhuijs, A K Boer
BACKGROUND: Vitamin B12 deficiency is common after bariatric surgery. Vitamin B12 is a poor predictor of functional vitamin B12 status, since deficiencies might even occur within the reference limits. Therefore, vitamin B12 deficiencies with serum vitamin B12 levels are between 140 and 200 pmol/L remain undetected. Methylmalonic acid (MMA), however, will detect these deficiencies as accumulates due to functional intracellular vitamin B12 deficiencies. MMA is a relative expensive analysis and is therefore not generally available...
July 2016: Obesity Surgery
https://www.readbyqxmd.com/read/26440032/evaluation-of-multiple-ancillary-therapies-used-in-combination-with-an-antimicrobial-in-newly-received-high-risk-calves-treated-for-bovine-respiratory-disease
#6
RANDOMIZED CONTROLLED TRIAL
B K Wilson, D L Step, C L Maxwell, J J Wagner, C J Richards, C R Krehbiel
Ancillary therapy (ANC) is commonly provided in conjunction with an antimicrobial when treating calves for suspected bovine respiratory disease (BRD) in an attempt to improve the response to a suspected BRD challenge. The first experiment evaluated the effects of 3 ANC in combination with an antimicrobial in high-risk calves treated for BRD during a 56-d receiving period. Newly received crossbred steers (n = 516; initial BW = 217 ± 20 kg) were monitored by trained personnel for clinical signs of BRD. Calves that met antimicrobial treatment criteria (n = 320) were then randomly assigned to experimental ANC treatment (80 steers/experimental ANC treatment): intravenous flunixin meglumine injection (NSAID), intranasal viral vaccination (VACC), intramuscular vitamin C injection (VITC), or no ANC (NOAC)...
July 2015: Journal of Animal Science
https://www.readbyqxmd.com/read/25433907/vitamin-k3-increased-bmd-at-1-and-2-months-post-surgery-and-the-maximum-stress-of-the-middle-femur-in-the-rat
#7
You-jia Hong, Sheng Liu, Ning-yi Jiang, Sen Jiang, Jiu-gen Liang
The therapeutic effects of vitamin K3 (VK3) on osteoporosis are still unknown. In this study, we hypothesized that VK3 possesses therapeutic effects on osteoporosis; to verify this hypothesis, the ovariectomized rat was used as an osteoporosis model. Fifty-six Sprague-Dawley female rats aged 8 to 9 months were randomly assigned to 4 groups: sham surgery, ovariectomy with saline, ovariectomy with low-dose VK3, and ovariectomy with high-dose VK3. Intramuscular injection of VK3 was performed every other day beginning 1 month postoperatively...
February 2015: Nutrition Research
https://www.readbyqxmd.com/read/25117994/treatment-of-vitamin-b12-deficiency-methylcobalamine-cyancobalamine-hydroxocobalamin-clearing-the-confusion
#8
K Thakkar, G Billa
Vitamin B12 (cyancobalamin, Cbl) has two active co-enzyme forms, methylcobalamin (MeCbl) and adenosylcobalamin (AdCbl). There has been a paradigm shift in the treatment of vitamin B12 deficiency such that MeCbl is being extensively used and promoted. This is despite the fact that both MeCbl and AdCbl are essential and have distinct metabolic fates and functions. MeCbl is primarily involved along with folate in hematopiesis and development of the brain during childhood. Whereas deficiency of AdCbl disturbs the carbohydrate, fat and amino-acid metabolism, and hence interferes with the formation of myelin...
January 2015: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/24793247/should-vitamin-b12-tablets-be-included-in-more-canadian-drug-formularies-an-economic-model-of-the-cost-saving-potential-from-increased-utilisation-of-oral-versus-intramuscular-vitamin-b12-maintenance-therapy-for-alberta-seniors
#9
COMPARATIVE STUDY
Sherilyn K D Houle, Michael R Kolber, Anderson W Chuck
OBJECTIVE: The aim of this study was to estimate the cost-savings attainable if all patients aged ≥65 years in Alberta, Canada, currently on intramuscular therapy were switched to oral therapy, from the perspective of a provincial ministry of health. SETTING: Primary care setting in Alberta, Canada. PARTICIPANTS: Seniors of age 65 years and older currently receiving intramuscular vitamin B12 therapy. INTERVENTION: Oral vitamin B12 therapy at 1000 μg/day versus intramuscular therapy at 1000 μg/month...
May 2, 2014: BMJ Open
https://www.readbyqxmd.com/read/24406570/impact-of-supplemental-vitamin-k1-administration-on-postoperative-blood-component-requirements-after-craniosynostosis-repair-a-prospective-placebo-controlled-randomized-blinded-study
#10
RANDOMIZED CONTROLLED TRIAL
Jennifer S Kicker, Douglas F Willson, Robin L Kelly, John A Jane, Sarah E Roberts, Mark R Conaway
Total cranial vault craniosynostosis repairs often require additional blood transfusions in the intensive care unit. Vitamin K1 participates in hepatic production of procoagulant proteins, and body stores of vitamin K1 are limited and dietary dependent. Surgical stress and diet interference may place infants at risk for vitamin K deficiency. Through design of a surgically stratified, randomized, placebo-controlled, blinded pilot study, we evaluated impact of vitamin K1 supplementation on coagulation parameters in infants after craniosynostosis repair...
January 2014: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/24401754/a-randomized-controlled-trial-on-safety-and-efficacy-of-single-intramuscular-versus-staggered-oral-dose-of-600-000iu-vitamin-d-in-treatment-of-nutritional-rickets
#11
RANDOMIZED CONTROLLED TRIAL
Krishanu Mondal, Anju Seth, Raman K Marwaha, Dinesh Dhanwal, Satinder Aneja, Ritu Singh, Pitambar Sonkar
OBJECTIVE: Comparison of efficacy and safety of two different regimens of vitamin D-600 000 IU as a single intramuscular dose, and 60 000IU orally once a week for 10 weeks-in treatment of nutritional rickets. METHODS: Children with nutritional rickets (age: 0.5-5 years, n = 61) were randomized to receive either 60 000IU vitamin D orally once a week for 10 weeks or 600 000IU single intramuscular injection. Serum calcium, phosphate, alkaline phosphatase, urinary calcium/creatinine ratio, serum 25 hydroxy vitamin D and radiological score were compared at 12-week follow-up...
June 2014: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/24226627/notes-from-the-field-late-vitamin-k-deficiency-bleeding-in-infants-whose-parents-declined-vitamin-k-prophylaxis-tennessee-2013
#12
(no author information available yet)
Vitamin K deficiency bleeding (VKDB) is a coagulopathy that develops in infants who do not have sufficient vitamin K stores to support production of clotting factors. In adults, vitamin K is absorbed from food and from vitamin K synthesized by gut bacteria. However, placental transfer in humans is limited; cord blood and infant liver reserve levels of vitamin K are substantially below adult levels. As a result, infants are predisposed to develop VKDB, which is classified as early, classic, and late, according to when it presents...
November 15, 2013: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/24059412/anaphylactic-shock-due-to-vitamin-k-in-a-newborn-and-review-of-literature
#13
REVIEW
Esad Koklu, Tuncay Taskale, Selmin Koklu, Erdal Avni Ariguloglu
Newborn infants are born with an immature innate immunity. They are less likely to develop anaphylaxis since their immune system is weaker than older infants and children. There are only a few reports of side effects after vitamin K injection in neonates although prophylaxis against hemorrhagic disease of the newborn with this drug has been in routine practice in all over the world for many years. We herein report a case of anaphylactic shock developing after the intramuscular administration of vitamin K1 in a newborn...
July 2014: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/23661838/effects-of-consumer-and-provider-moral-hazard-at-a-municipal-hospital-out-patient-department-on-ghana-s-national-health-insurance-scheme
#14
A E Yawson, R B Biritwum, P K Nimo
BACKGROUND: In 2003, Ghana introduced the national health insurance scheme (NHIS) to promote access to healthcare. This study determines consumer and provider factors which most influence the NHIS at a municipal health facility in Ghana. METHOD: This is an analytical cross-sectional study at the Winneba Municipal Hospital (WHM) in Ghana between January-March 2010. A total of 170 insured and 175 uninsured out-patients were interviewed and information extracted from their folders using a questionnaire...
December 2012: Ghana Medical Journal
https://www.readbyqxmd.com/read/23206235/management-of-methylergonovine-induced-respiratory-depression-in-a-newborn-with-naloxone
#15
R Sullivan, J Nelsen, S Duggineni, M Holland
INTRODUCTION: We report a case of a female neonate who developed respiratory depression following the unintentional administration of methylergonovine. The respiratory depression appeared to improve after the administration of bag mask ventilation, stimulation, and naloxone; and the baby was able to be managed without endotracheal intubation and prolonged positive-pressure ventilation. CASE: A full-term female neonate was delivered vaginally without issue. Approximately 10 min after delivery, the infant was inadvertently administered 0...
January 2013: Clinical Toxicology
https://www.readbyqxmd.com/read/23104564/management-of-nutritional-rickets-in-indian-children-a-randomized-controlled-trial
#16
RANDOMIZED CONTROLLED TRIAL
Varun Aggarwal, Anju Seth, Raman K Marwaha, Bhavna Sharma, Pitamber Sonkar, Satveer Singh, Satinder Aneja
INTRODUCTION: Rickets is usually attributed to vitamin D deficiency. However, recent studies have implicated dietary calcium deficiency in its etiology. Information on relative efficacy of calcium, vitamin D or both together in healing of rickets is limited. OBJECTIVE: To study effect of treatment with calcium, vitamin D or a combination of these two on healing of nutritional rickets in young children. DESIGN: Randomized controlled trial. METHODS: Sixty-seven cases of nutritional rickets in the age group of 6 months to 5 years were randomly allocated to receive vitamin D (600 000 IU single intramuscular dose), calcium (75 mg/kg/day elemental calcium orally) or a combination of the above two for a period of 12 weeks...
April 2013: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/23070343/differences-between-uni-and-multidimensional-scales-for-assessing-pain-in-term-newborn-infants-at-the-bedside
#17
Maria Carmenza Cuenca Arias, Ruth Guinsburg
OBJECTIVES: This study sought to determine the level of agreement between behavioral and multidimensional pain assessment scales in term newborn infants submitted to an acute nociceptive stimulus. METHODS: This cross-sectional study was performed on 400 healthy term newborns who received an intramuscular injection of vitamin K during the first 6 hours of life. Two behavioral pain scales (the Neonatal Facial Coding System and the Behavioral Indicators of Infant Pain) and one multidimensional tool (the Premature Infant Pain Profile) were applied by a single observer before the procedure, during cleansing, during injection and two minutes after injection...
October 2012: Clinics
https://www.readbyqxmd.com/read/22619475/use-of-oral-vitamin-k-for-prevention-of-late-vitamin-k-deficiency-bleeding-in-neonates-when-injectable-vitamin-k-is-not-available
#18
REVIEW
Heather J Ipema
OBJECTIVE: To evaluate the literature describing use of oral vitamin K(1) (phytonadione) to prevent late vitamin K deficiency bleeding (VKDB) in neonates when injectable vitamin K preparations are not available. DATA SOURCES: Articles were retrieved through MEDLINE (1946-February 2012) using the terms vitamin K, vitamin K deficiency bleeding, newborn, neonate, and prophylaxis. Reference citations from publications identified were reviewed. STUDY SELECTION AND DATA EXTRACTION: All articles published in English on the use of prophylactic oral vitamin K in neonates were evaluated...
June 2012: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/22572965/no-change-in-calcium-absorption-in-adult-pakistani-population-before-and-after-vitamin-d-administration-using-strontium-as-surrogate
#19
A H Khan, D K Rohra, S A Saghir, S K Udani, R J Wood, A Jabbar
UNLABELLED: Vitamin D, parathyroid hormone levels and calcium absorption was assessed before and after cholecalciferol using Strontium as a surrogate. Increase in 25OHD, lowering of iPTH with no effect on Sr absorption was seen, suggesting the possibility that maximal Ca absorption had already been achieved in these volunteers. INTRODUCTION: This paper discusses the determination of calcium (Ca) absorption, using strontium (Sr) as a surrogate, before and after a single IM injection of vitamin D(3) (600,000 IU)...
March 2013: Osteoporosis International
https://www.readbyqxmd.com/read/22515745/maternal-and-infant-characteristics-by-mode-of-vitamin-k-prophylaxis-administration
#20
COMPARATIVE STUDY
Amina Z Khambalia, Christine L Roberts, Jennifer R Bowen, Natasha Nassar
AIM:   The aim of this study was to compare maternal and infant characteristics by mode of VK administration. METHODS:   De-identified computerised birth files of all babies born in New South Wales (NSW), Australia between January 2007 and December 2009 (when VK prophylaxis was measured) were included in the present study. The outcome variable, mode of VK prophylaxis, was recorded by checkbox as oral, IM injection, none or not stated. RESULTS:   We analysed population-based birth data from 2007 to 2009 in NSW, Australia and found that IM injection was the most prevalent mode of administration (96...
August 2012: Journal of Paediatrics and Child Health
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