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https://www.readbyqxmd.com/read/27924072/p53-and-murine-double-mimute-2-mdm2-expression-changes-and-significance-in-different-types-of-endometrial-lesions
#1
Zhongyong Jiang, Wanqing Xu, Gang Dan, Yuan Liu, Jie Xiong
BACKGROUND Endometrial lesions are common in obstetrics and gynecology, including endometrial polyps, uterine adenomyosis, and malignant endometrial adenocarcinoma. Endometrial lesions seriously affect women's health, fertility, quality of life, and life safety. As a pro-apoptosis gene, p53 is considered to be closely related with human tumors. Murine double mimute 2 (MDM2) is an oncogene that can promote tumor occurrence and development. P53 and MDM2 expression and significance in different types of endometrial lesions have not been fully elucidated...
December 7, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27914969/endometrial-polyps-and-abnormal-uterine-bleeding-aub-p-what-is-the-relationship-how-are-they-diagnosed-and-how-are-they-treated
#2
REVIEW
T Justin Clark, Helen Stevenson
The diagnosis and treatment of endometrial polyps will be familiar to most gynaecologists. However, the aetiology and natural history of these focal intrauterine lesions are yet to be elucidated. This lack of clarity is also true with regard to their clinical significance; whilst endometrial polyps are highly prevalent in all types of abnormal uterine bleeding (AUB), they are also commonly found in women without AUB. These controversies will be discussed along with current thoughts on the diagnosis and treatment of endometrial polyps...
October 1, 2016: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/27904953/endometrial-preparation-with-dienogest-before-hysteroscopic-surgery-a-systematic-review
#3
Antonio Simone Laganà, Salvatore Giovanni Vitale, Vincenzo Muscia, Paola Rossetti, Massimo Buscema, Onofrio Triolo, Agnese Maria Chiara Rapisarda, Loretta Giunta, Vittorio Palmara, Roberta Granese, Helena Ban Frangež, Andrea Romano
PURPOSE: Hysteroscopic surgery is considered the gold standard for the minimal invasive treatment of many endouterine diseases such as endometrial polyps or submucous myomas. Recently, many studies have evaluated the effect of preoperative administration of a number of drugs to reduce endometrial thickness and achieve important intraoperative advantages. The purpose of this systematic review is to summarize the available evidence about the use of Dienogest, an orally administrable progestin, for endometrial preparation before hysteroscopic surgery...
November 30, 2016: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/27902476/stromal-p16-expression-is-significantly-increased-in-endometrial-carcinoma
#4
Gun Yoon, Chang Won Koh, Nara Yoon, Ji-Ye Kim, Hyun-Soo Kim
p16 is a negative regulator of cell proliferation and is considered a tumor suppressor protein. Alterations in p16 protein expression are associated with tumor development and progression. However, the p16 expression status in the peritumoral stroma has not been investigated in the endometrium. Therefore, we evaluated stromal p16 expression in different types of endometrial lesions using immunohistochemistry. Differences in the p16 expression status according to the degree of malignancy and histological type were analyzed...
November 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27862684/injury-to-the-endometrium-prior-to-the-frozen-thawed-embryo-transfer-cycle-improves-pregnancy-rates-in-patients-with-repeated-implantation-failure
#5
Emiko Kanazawa, Akira Nakashima, Koji Yonemoto, Misako Otsuka, Naomi Yoshioka, Takeshi Kuramoto, Hiroshi Mitao, Hiroto Imaishi, Kan Komai, Kimio Ushijima
AIM: This retrospective cohort study evaluated the effectiveness of injury to the endometrium prior to the frozen-thawed embryo transfer (FET) cycle in patients with repeated implantation failure (RIF) in our clinic. METHODS: Included in this study were 173 patients, aged ≤ 41 years, who failed to become pregnant after repeating fair and/or good embryo transfer more than twice between February 2012 and February 2015. The patients were divided into three groups: Group A (n = 38) underwent soft curettage to the endometrium twice, prior to the FET cycle; Group B (n = 45) underwent hysteroscopy prior to the FET cycle, with no significant factors, such as endometrial polyp; and Group C (n = 90) was the no-treatment group...
November 12, 2016: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/27862503/accuracy-of-saline-contrast-sonohysterography-in-detection-of-endometrial-polyps-and-submucosal-leiomyoma-in-women-at-reproductive-age-with-abnormal-uterine-bleeding-a-systematic-review-and-meta-analysis
#6
REVIEW
Carolina Abdou Bittencourt, Ricardo Dos Santos Simões, Wanderley Marques Bernardo, Luiz Fernando Portugal Fuchs, José Maria Soares Junior, Ayrton Roberto Pastore, Edmund Chada Baracat
OBJECTIVE: To analyze the diagnostic accuracy of 2D and 3D saline contrast sonohysterography compared to hysteroscopy in the detection of endometrial polyps and submucosal myomas in women during reproductive age with abnormal uterine bleeding. METHOD: A systematic review of diagnostic studies that compared saline contrast sonohysterography with hysteroscopy was conducted according to the PRISMA and SEDATE recommendations. Only studies that compared two and/or three dimensional saline contrast sonohysterography with hysteroscopy and anatomopathology were included...
November 15, 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27861704/is-outpatient-hysteroscopy-the-new-gold-standard-results-from-an-11-year-prospective-observational-study
#7
Tony Ma, Emma Readman, Lauren Hicks, Jenny Porter, Melissa Cameron, Lenore Ellett, Kate Mcilwaine, Janine Manwaring, Peter Maher
BACKGROUND: In Australia, gynaecologists continue to investigate women with abnormal bleeding and suspected intrauterine pathology with inpatient hysteroscopy despite some evidence in the literature that that there is no difference in safety and outcome when compared to an outpatient procedure. AIMS: This prospective study assessed the safety, effectiveness and acceptability of outpatient hysteroscopy over 11 years at a tertiary hospital in Australia. Resource savings were then calculated...
November 15, 2016: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/27858862/utility-of-t-cell-interferon-%C3%AE-release-assays-for-the-diagnosis-of-female-genital-tuberculosis-in-a-tertiary-referral-hospital-in-beijing-china
#8
Xiaoqing Liu, Sainan Bian, Xinhe Cheng, Wenze Wang, Qinjie Tian, Lifan Zhang, Yueqiu Zhang, Xiaochun Shi, Yao Zhang, Zhiyong Liang
Diagnosis of female genital tuberculosis (FGTB) remains a challenge. The aim of this study was to evaluate the diagnostic value of T-SPOT.TB on peripheral blood mononuclear cells (PBMCs) for diagnosing FGTB in an area with high TB burden.Patients with suspected FGTB were enrolled consecutively between August 2010 and August 2015. T-SPOT.TB on PBMCs and histopathology were performed in all patients. T-SPOT.TB results were evaluated against patients' final diagnosis of FGTB which was made based on clinical manifestations, radiology, microbiological and histopathological evaluation, and response to anti-TB treatment...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27849337/the-role-of-oxidative-stress-markers-in-development-of-endometrial-polyp
#9
Mehmet Çınar, Özlem Gün Eryılmaz, Şule Özel, Rahime Bedir Fındık, Hatice Kansu, Gülnur Özakşit
OBJECTIVE: To evaluate the association of the oxidative stress markers in patients with endometrial polyp. METHODS: A total of forty nine patients between 28-47 years of ages who have a suspect evidence of endometrial polyp on transvaginal sonography were enrolled for the study. Hysterosonography was applied all of the patients and patients then were divided into two groups in terms of their hysteroscopic findings. Group 1(control group, n=27) defined who has no endometrial pathology and group 2 (study group, n=22) defined has one or more endometrial polyp on hysteroscopy with guided biopsy...
November 2016: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/27834479/-resectoscope-versus-small-diameter-hysteroscopy-for-endometrial-polypectomy-in-patients-with-unfavorable-cervix
#10
Pasquale De Franciscis, Flavio Grauso, Enrico M Messalli, Maria T Schettino, Gloria Calagna, Antonino Perino, Nicola Colacurci, Marco Torella
BACKGROUND: To compare resectoscopic and small-diameter hysteroscopic techniques for endometrial polypectomy in patients with "unfavorable" cervix. METHODS: Eighty women with a single 2-4 cm sized endometrial polyp, with unfavorable cervical anatomical conditions were enrolled in the study. Forty patients were treated with a 26F resectoscope requiring cervical dilatation (group A), forty patients were treated with a 5-mm hysteroscope requiring vaginoscopic approach (group B)...
November 11, 2016: Minerva Ginecologica
https://www.readbyqxmd.com/read/27834002/feasibility-of-hysteroscopic-endometrial-polypectomy-using-a-new-dual-wavelengths-laser-system-dwls-preliminary-results-of-a-pilot-study
#11
Luigi Nappi, Felice Sorrentino, Stefano Angioni, Alessandro Pontis, Pietro Litta, Pantaleo Greco
PURPOSE: Currently, endometrial polyps may be successfully treated in an outpatient setting with 5 Fr mechanical and bipolar instruments. Our aim is to evaluate the benefits of minimally invasive techniques in hysteroscopy, focusing on the use of a new dual wavelengths laser system in the treatment of endometrial polyps in an outpatient setting. METHODS: Between September 2012 and December 2014, all consecutive patients of reproductive and menopausal age with ultrasound diagnosis of endometrial polyp with maximum diameter ≤2...
November 11, 2016: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/27829198/role-of-diffusion-weighted-mri-in-the-differential-diagnosis-of-endometrial-cancer-polyp-hyperplasia-and-physiological-thickening
#12
Baris Bakir, Sükrü Sanli, Vuslat Lale Bakir, Selcuk Ayas, Sevda Ozel Yildiz, Ahmet Cem Iyibozkurt, Merve Gülbiz Kartal, Ekrem Yavuz
Our purpose was to evaluate the role of diffusion-weighted imaging (DWI) in the diagnosis of various common pathologies of the uterine cavity, by comparing them with contrast-enhanced MRI findings. One hundred sixty-four patients with lesions in endometrial cavity were included in the study. The patients were grouped in four (one malignant and three benign groups). We have observed that the differences of the apparent diffusion coefficient, b1000q, and Cq values between various common benign and malignant lesions were statistically significant (P<...
October 20, 2016: Clinical Imaging
https://www.readbyqxmd.com/read/27818130/structured-imaging-technique-in-the-gynecologic-office-for-the-diagnosis-of-abnormal-uterine-bleeding
#13
REVIEW
Margit Dueholm, Ina Marie D Hjorth
: The aim in the diagnosis of abnormal uterine bleeding (AUB) is to identify the bleeding cause, which can be classified by the PALM-COEIN (Polyp, Adenomyosis, Leiomyoma, Malignancy (and hyperplasia), Coagulopathy, Ovulatory disorders, Endometrial, Iatrogenic and Not otherwise classified) classification system. In a gynecologic setting, the first step is most often to identify structural abnormalities (PALM causes). Common diagnostic options for the identification of the PALM include ultrasonography, endometrial sampling, and hysteroscopy...
October 1, 2016: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/27801761/endometrial-thickness-as-measured-by-transvaginal-ultrasound-and-the-corresponding-histopathologic-diagnosis-in-women-with-postmenopausal-bleeding
#14
Vatsal Patel, Edward J Wilkinson, Srikar Chamalan, Xiaomin Lu, Jacqueline Costagno, Demaretta Rush
Endometrial thickness as measured by transvaginal ultrasound (TVUS) is being increasingly used as a first-line method to evaluate patients with vaginal bleeding. Our study aims to examine correlation between the histopathologic diagnosis and the results of TVUS and find a threshold that could reliably exclude carcinoma. We included women, age 55 years and above, who presented with postmenopausal bleeding and had a TVUS within 30 days of their endometrial biopsy. Total of 304 patients met our criteria and were divided into 4 groups...
October 31, 2016: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/27769260/submucous-uterine-adenosarcoma-minimally-invasive-treatment
#15
H Krentel, R L De Wilde
BACKGROUND: Uterine adenosarcomas are rare malignant gynaecological tumours. Due to its submucous localization, they can be easily confound with benign tumours like endometrial polyps or submucous myomas. However, the treatment of uterine adenosarcomas requires an oncologic surgical approach. CASE PRESENTATION: In the following case report, we present the minimally invasive treatment of a uterine adenosarcoma by hysteroscopy and laparoscopy in a 37-year-old patient and discuss the special role of hysteroscopy in such cases...
October 21, 2016: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27769088/accuracy-of-transvaginal-ultrasonography-hysteroscopy-and-uterine-curettage-in-evaluating-endometrial-pathologies
#16
Miriam da Silva Wanderley, Miriam Monteiro Álvares, Maria de Fátima Brito Vogt, Lizandra Moura Paravidine Sazaki
Objective To evaluate the accuracy of transvaginal ultrasonography, hysteroscopy and uterine curettage in the diagnosis of endometrial polyp, submucous myoma and endometrial hyperplasia, using as gold standard the histopathological analysis of biopsy samples obtained during hysteroscopy or uterine curettage. Methods Cross-sectional study performed at the Hospital Universitário de Brasília (HUB). Data were obtained from the charts of patients submitted to hysteroscopy or uterine curettage in the period from July 2007 to July 2012...
October 2016: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/27746268/association-of-ovarian-hyperthecosis-with-endometrial-polyp-endometrial-hyperplasia-and-endometrioid-adenocarcinoma-in-postmenopausal-women-a-clinicopathologic-study-of-238-cases
#17
Cunxian Zhang, C James Sung, M Ruhul Quddus, Rochelle A Simon, Tarek Jazaerly, W Dwayne Lawrence
Ovarian hyperthecosis, a source of estrogen, may occur in postmenopausal women. In this study, we evaluated the possible association of ovarian hyperthecosis with endometrial polyp, endometrial hyperplasia, and endometrioid adenocarcinoma in postmenopausal women. Our study consisted of 238 postmenopausal women: 108 with endometrioid adenocarcinoma and 130 without endometrial carcinoma. The International Federation of Gynecology and Obstetrics system was used to grade endometrioid adenocarcinoma. Within the endometrioid adenocarcinoma cases, 48 (44...
October 13, 2016: Human Pathology
https://www.readbyqxmd.com/read/27738813/-endometritis-rare-disease-with-clinical-importance
#18
S F Lax
Endometritis is nowadays rare in developed countries and typically shows a subclinical or mild course; therefore, there are probably more cases of endometritis than diagnosed but they lack clinical relevance. In the fertile period of life it can be the reason for vaginal bleeding and infertility. The most common causes for non-specific endometritis are residual placental tissue after abortion or childbirth, intrauterine interventions, lesions within the uterine cavity, such as endometrial polyps, endometrial hyperplasia and neoplasms, intrauterine devices (IUD) and cervical stenosis...
October 13, 2016: Der Pathologe
https://www.readbyqxmd.com/read/27738097/sarcoidosis-in-an-endometrial-polyp
#19
Mohamed Rizwan Haroon Al Rasheed, Oluwatobi Adelaja, Gabor Tarjan
No abstract text is available yet for this article.
October 13, 2016: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27734113/through-thick-and-thin-a-pictorial-review-of-the-endometrium
#20
Melanie P Caserta, Candice Bolan, M Jennings Clingan
The purpose of this pictorial review is to describe the normal appearance of the endometrium and to provide radiologists with an overview of endometrial pathology utilizing case examples. The normal appearance of the endometrium varies by age, menstrual phase, and hormonal status with differing degrees of acceptable endometrial thickness. Endometrial pathology most often manifests as either focal or diffuse endometrial thickening, and patients frequently present with abnormal vaginal bleeding. Endovaginal ultrasound (US) is the first-line modality for imaging the endometrium...
October 12, 2016: Abdominal Radiology
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