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https://www.readbyqxmd.com/read/28214732/persistent-rna-virus-infections-do-pamps-drive-chronic-disease
#1
REVIEW
Mary K McCarthy, Thomas E Morrison
Chronic disease associated with persistent RNA virus infections represents a key public health concern. While human immunodeficiency virus-1 and hepatitis C virus are perhaps the most well-known examples of persistent RNA viruses that cause chronic disease, evidence suggests that many other RNA viruses, including re-emerging viruses such as chikungunya virus, Ebola virus and Zika virus, establish persistent infections. The mechanisms by which RNA viruses drive chronic disease are poorly understood. Here, we discuss how the persistence of viral RNA may drive chronic disease manifestations via the activation of RNA sensing pathways...
February 16, 2017: Current Opinion in Virology
https://www.readbyqxmd.com/read/28208277/ultrasensitive-ebola-virus-detection-based-on-electroluminescent-nanospheres-and-immunomagnetic-separation
#2
Zhen Wu, Jiao Hu, Tao Zeng, Zhi-Ling Zhang, Jianjun Chen, Gary Wong, Xiangguo Qiu, Wenjun Liu, George F Gao, Yuhai Bi, Dai-Wen Pang
The 2014-16 Ebola virus (EBOV) outbreak in West Africa has attracted widespread concern. Rapid and sensitive detection methods are urgently needed for diagnosis and treatment of the disease. Here, we propose a novel method for EBOV detection based on efficient amplification of electroluminescent nanospheres (ENs) coupled with immunomagnetic separation. Uniform ENs are made by embedding abundant amounts of CdSe/ZnS quantum dots (QDs) into copolymer nanospheres through simple ultrasound. Compared to QDs, ENs can enhance electroluminescence (ECL) signals by approximately 85-fold, achieving a signal-to-background ratio high enough for EBOV detection...
February 7, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28207078/emerging-infectious-diseases-animals-and-future-epidemics
#3
Herbert L DuPont
Emerging and reemerging infections have become prevalent in the United States since the 1970s, causing illness, death, and fear among the public. The published literature was reviewed to offer a perspective on risk factors for disease acquisition and to allow a prediction of the next microbial assault after Ebola and Zika. Four well-integrated factors likely will contribute simultaneously: animals colonized or infected by pathogens capable of human transmission, microbes recurrently changing their virulence, a growing number of susceptible people, and climatic and environmental factors encouraging disease transmission...
February 1, 2017: Texas Medicine
https://www.readbyqxmd.com/read/28207062/impact-of-interventions-and-the-incidence-of-ebola-virus-disease-in-liberia-implications-for-future-epidemics
#4
Thomas D Kirsch, Heidi Moseson, Moses Massaquoi, Tolbert G Nyenswah, Rachel Goodermote, Isabel Rodriguez-Barraquer, Justin Lessler, Derek A T Cumings, David H Peters
No abstract text is available yet for this article.
March 1, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/28205617/an-empirical-analysis-of-the-ebola-outbreak-in-west-africa
#5
Abdul Khaleque, Parongama Sen
The data for the Ebola outbreak that occurred in 2014-2016 in three countries of West Africa are analysed within a common framework. The analysis is made using the results of an agent based Susceptible-Infected-Removed (SIR) model on a Euclidean network, where nodes at a distance l are connected with probability P(l) ∝ l(-δ), δ determining the range of the interaction, in addition to nearest neighbors. The cumulative (total) density of infected population here has the form , where the parameters depend on δ and the infection probability q...
February 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28205249/exploration-micromechanism-of-vp35-iid-interaction-and-recognition-dsrna-a-molecular-dynamics-simulation
#6
Yan-Jun Zhang, Jing-Na Ding, Hui Zhong, Ju-Guang Han
Multifunctional viral protein (VP35) encoded by the highly pathogenic Ebola viruses (EBOVs) can antagonize host double-stranded RNA (dsRNA) sensors and immune response because of the simultaneous recognition of dsRNA backbone and blunt ends. Mutation of select hydrophobic conserved basic residues within the VP35 inhibitory domain (IID) abrogates its dsRNA-binding activity, and impairs VP35-mediated interferon (IFN) antagonism. Herein the detailed binding mechanism between dsRNA and WT, single mutant, and double mutant were investigated by all-atom molecular dynamics (MD) simulation and binding energy calculation...
February 16, 2017: Proteins
https://www.readbyqxmd.com/read/28202764/trim25-is-required-for-the-antiviral-activity-of-zinc-finger-antiviral-protein-zap
#7
Xiaojiao Zheng, Xinlu Wang, Fan Tu, Qin Wang, Zusen Fan, Guangxia Gao
Zinc-finger antiviral protein (ZAP) is a host factor that specifically inhibits the replication of certain viruses by binding to viral mRNAs, and repressing the translation and/or promoting the degradation of target mRNA. In addition, ZAP regulates the expression of certain cellular genes. Here, we report that tripartite motif-containing protein 25 (TRIM25), a ubiquitin E3 ligase, is required for the antiviral activity of ZAP. Downregulation of endogenous TRIM25 abolished ZAP's antiviral activity. The E3 ligase activity of TRIM25 is required for this regulation...
February 15, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28202592/extinction-pathways-and-outbreak-vulnerability-in-a-stochastic-ebola-model
#8
Garrett T Nieddu, Lora Billings, James H Kaufman, Eric Forgoston, Simone Bianco
A zoonotic disease is a disease that can be passed from animals to humans. Zoonotic viruses may adapt to a human host eventually becoming endemic in humans, but before doing so punctuated outbreaks of the zoonotic virus may be observed. The Ebola virus disease (EVD) is an example of such a disease. The animal population in which the disease agent is able to reproduce in sufficient number to be able to transmit to a susceptible human host is called a reservoir. There is little work devoted to understanding stochastic population dynamics in the presence of a reservoir, specifically the phenomena of disease extinction and reintroduction...
February 2017: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/28202435/post-ebola-reforms-deserve-support
#9
EDITORIAL
Margaret F C Chan
No abstract text is available yet for this article.
February 15, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28200119/changes-associated-with-ebola-virus-adaptation-to-novel-species
#10
Morena Pappalardo, Ian Reddin, Diego Cantoni, Jeremy S Rossman, Martin Michaelis, Mark N Wass
No abstract text is available yet for this article.
February 15, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28199801/trial-of-zmapp-for-ebola-virus-infection
#11
LETTER
(no author information available yet)
No abstract text is available yet for this article.
16, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28198759/how-specialty-certification-influences-professional-practice
#12
Sharon Vanairsdale
Certified Nurses Day (March 19) honors nurses worldwide who contribute to better patient outcomes through board certification in their specialty. In this month's Magnet® Perspectives column, Sharon Vanairsdale, MS, APRN, ACNS-BC, NP-C, CEN, program director for Emory University Hospital's Serious Communicable Diseases Unit, discusses the value of certification, what it means to her professional practice, and how it helps to champion her work. Ms Vanairsdale is triple certified as a certified emergency nurse, an adult clinical nurse specialist, and an adult nurse practitioner...
March 2017: Journal of Nursing Administration
https://www.readbyqxmd.com/read/28197405/on-the-helix-propensity-in-generalized-born-solvent-descriptions-of-modeling-the-dark-proteome
#13
Mark A Olson
Intrinsically disordered proteins that populate the so-called "Dark Proteome" offer challenging benchmarks of atomistic simulation methods to accurately model conformational transitions on a multidimensional energy landscape. This work explores the application of parallel tempering with implicit solvent models as a computational framework to capture the conformational ensemble of an intrinsically disordered peptide derived from the Ebola virus protein VP35. A recent X-ray crystallographic study reported a protein-peptide interface where the VP35 peptide underwent a folding transition from a disordered form to a helix-β-turn-helix topological fold upon molecular association with the Ebola protein NP...
2017: Frontiers in Molecular Biosciences
https://www.readbyqxmd.com/read/28197401/lack-of-cultural-competency-in-international-aid-responses-the-ebola-outbreak-in-liberia
#14
Hannah Grace Southall, Sarah E DeYoung, Curt Andrew Harris
A cornerstone of effective disaster management is that response should always begin and end at the local level (1). The response to the Ebola virus disease (EVD) outbreak in Liberia, West Africa, was a combination of independent efforts by many nations and organizations. Many of these independent efforts ignored or were not able to work with the local levels of emergency management in Liberia. This oversight occurred because of the Liberian's mistrust of both their government and foreign aid groups, as well as the lack of cultural competency demonstrated by the aid groups...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28197304/ester-prodrugs-of-ihvr-19029-with-enhanced-oral-exposure-and-prevention-of-gastrointestinal-glucosidase-interaction
#15
Julia Ma, Shuo Wu, Xuexiang Zhang, Fang Guo, Katherine Yang, Jia Guo, Qing Su, Huagang Lu, Patrick Lam, Yuhuan Li, Zhengyin Yan, William Kinney, Ju-Tao Guo, Timothy M Block, Jinhong Chang, Yanming Du
IHVR-19029 (6) is a lead endoplasmic reticulum α-glucosidases I and II inhibitor, which efficiently protected mice from lethal Ebola and Marburg virus infections via injection route, but suffered from low bioavailability and off-target interactions with gut glucosidases when administered orally. In an effort to improve efficacious exposure levels and avoid side effects, we designed and synthesized ester prodrugs. Not only were the prodrugs stable in simulated gastric and intestinal fluids and were inactive against glucosidases but they also exhibited antiviral activities against dengue virus infection in a cell based assay...
February 9, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28196864/mechanistic-understanding-of-n-glycosylation-in-ebola-virus-glycoprotein-maturation-and-function
#16
Bin Wang, Yujie Wang, Dylan A Frabutt, Xihe Zhang, Xiaoyu Yao, Dan Hu, Zhuo Zhang, Chaonan Liu, Shimin Zheng, Shi-Hua Xiang, Yong-Hui Zheng
The Ebola virus (EBOV) trimeric envelope glycoprotein (GP) precursors are cleaved into the receptor-binding GP1 and the fusion-mediating GP2 subunits and incorporated into virions to initiate infection. GP1 and GP2 form heterodimers, which have 15 or 2 N-glycosylation sites (NGSs), respectively. Here, we investigated the mechanism of how N-glycosylation contributes to GP expression, maturation, and function. As reported before, we found that although GP1 NGSs are not critical, the two GP2 NGSs, N563 and N618, are essential to the GP function...
February 14, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28195145/the-nexus-between-forest-fragmentation-in-africa-and-ebola-virus-disease-outbreaks
#17
Maria Cristina Rulli, Monia Santini, David T S Hayman, Paolo D'Odorico
Tropical forests are undergoing land use change in many regions of the world, including the African continent. Human populations living close to forest margins fragmented and disturbed by deforestation may be particularly exposed to zoonotic infections because of the higher likelihood for humans to be in contact with disease reservoirs. Quantitative analysis of the nexus between deforestation and the emergence of Ebola virus disease (EVD), however, is still missing. Here we use land cover change data in conjunction with EVD outbreak records to investigate the association between recent (2004-2014) outbreaks in West and Central Africa, and patterns of land use change in the region...
February 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28193880/spatial-and-temporal-dynamics-of-superspreading-events-in-the-2014-2015-west-africa-ebola-epidemic
#18
Max S Y Lau, Benjamin Douglas Dalziel, Sebastian Funk, Amanda McClelland, Amanda Tiffany, Steven Riley, C Jessica E Metcalf, Bryan T Grenfell
The unprecedented scale of the Ebola outbreak in Western Africa (2014-2015) has prompted an explosion of efforts to understand the transmission dynamics of the virus and to analyze the performance of possible containment strategies. Models have focused primarily on the reproductive numbers of the disease that represent the average number of secondary infections produced by a random infectious individual. However, these population-level estimates may conflate important systematic variation in the number of cases generated by infected individuals, particularly found in spatially localized transmission and superspreading events...
February 13, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28193386/the-ebola-suspect-s-dilemma
#19
Eugene T Richardson, Mohamed Bailor Barrie, Cameron T Nutt, J Daniel Kelly, Raphael Frankfurter, Mosoka P Fallah, Paul E Farmer
No abstract text is available yet for this article.
March 2017: Lancet Global Health
https://www.readbyqxmd.com/read/28193382/persistence-of-immune-responses-induced-by-ebola-virus-vaccines
#20
Matthew D Snape
No abstract text is available yet for this article.
March 2017: Lancet Global Health
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