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https://www.readbyqxmd.com/read/28081225/fighting-ebola-a-window-for-vaccine-re-evaluation
#1
Keith J Chappell, Daniel Watterson
No abstract text is available yet for this article.
January 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28076420/chaperone-mediated-autophagy-protein-bag3-negatively-regulates-ebola-and-marburg-vp40-mediated-egress
#2
Jingjing Liang, Cari A Sagum, Mark T Bedford, Sachdev S Sidhu, Marius Sudol, Ziying Han, Ronald N Harty
Ebola (EBOV) and Marburg (MARV) viruses are members of the Filoviridae family which cause outbreaks of hemorrhagic fever. The filovirus VP40 matrix protein is essential for virus assembly and budding, and its PPxY L-domain motif interacts with WW-domains of specific host proteins, such as Nedd4 and ITCH, to facilitate the late stage of virus-cell separation. To identify additional WW-domain-bearing host proteins that interact with VP40, we used an EBOV PPxY-containing peptide to screen an array of 115 mammalian WW-domain-bearing proteins...
January 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28075069/ebola-vaccination-using-a-dna-vaccine-coated-on-plga-pll-%C3%AE-pga-nanoparticles-administered-using-a-microneedle-patch
#3
Hung-Wei Yang, Ling Ye, Xin Dong Guo, Chinglai Yang, Richard W Compans, Mark R Prausnitz
Ebola DNA vaccine is incorporated into PLGA-PLL/γPGA nanoparticles and administered to skin using a microneedle (MN) patch. The nanoparticle delivery system increases vaccine thermostability and immunogenicity compared to free vaccine. Vaccination by MN patch produces stronger immune responses than intramuscular administration.
January 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28074834/corrigendum-differential-transcriptional-responses-to-ebola-and-marburg-virus-infection-in-bat-and-human-cells
#4
Martin Hölzer, Verena Krähling, Fabian Amman, Emanuel Barth, Stephan H Bernhart, Victor A O Carmelo, Maximilian Collatz, Gero Doose, Florian Eggenhofer, Jan Ewald, Jörg Fallmann, Lasse M Feldhahn, Markus Fricke, Juliane Gebauer, Andreas J Gruber, Franziska Hufsky, Henrike Indrischek, Sabina Kanton, Jörg Linde, Nelly Mostajo, Roman Ochsenreiter, Konstantin Riege, Lorena Rivarola-Duarte, Abdullah H Sahyoun, Sita J Saunders, Stefan E Seemann, Andrea Tanzer, Bertram Vogel, Stefanie Wehner, Michael T Wolfinger, Rolf Backofen, Jan Gorodkin, Ivo Grosse, Ivo Hofacker, Steve Hoffmann, Christoph Kaleta, Peter F Stadler, Stephan Becker, Manja Marz
No abstract text is available yet for this article.
January 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28073859/experimental-therapies-for-ebola-virus-disease-what-have-we-learned
#5
EDITORIAL
Frederick G Hayden, Martin Friede, Daniel G Bausch
No abstract text is available yet for this article.
January 9, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28073857/first-newborn-baby-to-receive-experimental-therapies-survives-ebola-virus-disease
#6
Jenny Dörnemann, Chiara Burzio, Axelle Ronsse, Armand Sprecher, Hilde De Clerck, Michel Van Herp, Marie-Claire Kolié, Vesselina Yosifiva, Severine Caluwaerts, Anita K McElroy, Annick Antierens
A neonate born to an Ebola virus-positive woman was diagnosed with Ebola virus infection on her first day of life. The patient was treated with monoclonal antibodies (ZMapp), a buffy coat transfusion from an Ebola survivor, and the broad-spectrum antiviral GS-5734. On day 20, a venous blood specimen tested negative for Ebola virus by quantitative reverse-transcription polymerase chain reaction. The patient was discharged in good health on day 33 of life. Further follow-up consultations showed age-appropriate weight gain and neurodevelopment at the age of 12 months...
January 9, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28073029/multiplexed-efficient-on-chip-sample-preparation-and-sensitive-amplification-free-detection-of-ebola-virus
#7
K Du, H Cai, M Park, T A Wall, M A Stott, K J Alfson, A Griffiths, R Carrion, J L Patterson, A R Hawkins, H Schmidt, R A Mathies
An automated microfluidic sample preparation multiplexer (SPM) has been developed and evaluated for Ebola virus detection. Metered air bubbles controlled by microvalves are used to improve bead-solution mixing thereby enhancing the hybridization of the target Ebola virus RNA with capture probes bound to the beads. The method uses thermally stable 4-formyl benzamide functionalized (4FB) magnetic beads rather than streptavidin coated beads with a high density of capture probes to improve the target capture efficiency...
January 3, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28065333/preparedness-planning-and-care-of-patients-under-investigation-for-or-with-ebola-virus-disease-a-survey-of-physicians-in-north-america
#8
Jessica D Lewis, Kyle B Enfield, Trish M Perl, Costi D Sifri
The West African Ebola virus disease (EVD) epidemic of 2014-2015 required North American hospitals to undertake comprehensive planning and training for the potential need to care for patients with EVD. Here we describe physician contributions to EVD preparedness planning and the care of persons under investigation for or patients with EVD.
January 1, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28064527/child-violence-experiences-in-institutionalised-orphanage-care
#9
Lorraine Sherr, Kathryn J Roberts, Natasha Gandhi
Institutions are not necessarily good environments for children. In the face of challenges such as HIV, Ebola, poverty, conflict and disaster the numbers have grown rather than reduced. Some countries have closed institutions down -driven by findings that cognitive developmental delay is associated with institutional care. Yet insight into abuse and violence within institutionalised settings is neglected. Maltreatment -violence and abuse -may be an issue. This systematic review series addresses violence and abuse experiences in institutionalised care, exploring firstly the frequency of abuse/violence in institutions, secondly any interventions to reduce such violence or abuse and thirdly the perpetrators of such violence or abuse...
January 9, 2017: Psychology, Health & Medicine
https://www.readbyqxmd.com/read/28063566/lignes-directrices-quant-%C3%A3-la-prise-en-charge-au-canada-d-une-femme-enceinte-ayant-%C3%A3-t%C3%A3-expos%C3%A3-e-%C3%A3-la-maladie-%C3%A3-virus-ebola-ou-ayant-%C3%A3-t%C3%A3-infect%C3%A3-e-par-ce-virus
#10
Deborah Money
No abstract text is available yet for this article.
December 2016: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28061463/prevalence-of-psychological-symptoms-among-ebola-survivors-and-healthcare-workers-during-the-2014-2015-ebola-outbreak-in-sierra-leone-a-cross-sectional-study
#11
Dong Ji, Ying-Jie Ji, Xue-Zhang Duan, Wen-Gang Li, Zhi-Qiang Sun, Xue-Ai Song, Yu-Hua Meng, Hong-Mei Tang, Fang Chu, Xiao-Xia Niu, Guo-Feng Chen, Jin Li, Hui-Juan Duan
The 2014-2015 Ebola epidemic was considered to be the largest and most complex outbreak, which caused 11,310 reported deaths. The epidemic disease can cause a mental health crisis, however, there is only a small amount of scientific literature available related to this health issue so far. We evaluated the psychological symptoms of 161 participants including Ebola survivors and healthcare workers in Sierra Leone, analyzed the impact of job classification, education level on psychological status. We found that the order of total general severity index (GSI) scores from high to low was EVD survivors, SL medical staff, SL logistic staff, SL medical students, and Chinese medical staff...
January 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28057259/modified-vaccinia-virus-ankara-history-value-in-basic-research-and-current-perspectives-for-vaccine-development
#12
A Volz, G Sutter
Safety tested Modified Vaccinia virus Ankara (MVA) is licensed as third-generation vaccine against smallpox and serves as a potent vector system for development of new candidate vaccines against infectious diseases and cancer. Historically, MVA was developed by serial tissue culture passage in primary chicken cells of vaccinia virus strain Ankara, and clinically used to avoid the undesirable side effects of conventional smallpox vaccination. Adapted to growth in avian cells MVA lost the ability to replicate in mammalian hosts and lacks many of the genes orthopoxviruses use to conquer their host (cell) environment...
2017: Advances in Virus Research
https://www.readbyqxmd.com/read/28057165/current-and-future-diagnostic-tests-for-ebola-virus-disease
#13
Bharti Singh, Advaita Ganguly, Hoon H Sunwoo
Ebola virus disease (EVD) is a major public health concern with a high mortality rate in infected individuals. Outbreaks of Ebola have been widespread-there is no rapid, sensitive, specific, and affordable diagnostic test for the virus, nor there is any treatment for the disease. Overlapping symptoms of other endemic diseases, such as malaria and cholera, make it difficult to diagnose EVD. For clinical management, outbreak investigation, and proper surveillance, EVD requires a detection system, which should be fast, sensitive, specific, efficient, affordable, and user-friendly with in-country staff...
October 2016: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28056096/detection-of-viral-rna-in-tissues-following-plasma-clearance-from-an-ebola-virus-infected-patient
#14
Mirella Biava, Claudia Caglioti, Licia Bordi, Concetta Castilletti, Francesca Colavita, Serena Quartu, Emanuele Nicastri, Francesco Nicola Lauria, Nicola Petrosillo, Simone Lanini, Thomas Hoenen, Gary Kobinger, Alimuddin Zumla, Antonino Di Caro, Giuseppe Ippolito, Maria Rosaria Capobianchi, Eleonora Lalle
An unprecedented Ebola virus (EBOV) epidemic occurred in 2013-2016 in West Africa. Over this time the epidemic exponentially grew and moved to Europe and North America, with several imported cases and many Health Care Workers (HCW) infected. Better understanding of EBOV infection patterns in different body compartments is mandatory to develop new countermeasures, as well as to fully comprehend the pathways of human-to-human transmission. We have longitudinally explored the persistence of EBOV-specific negative sense genomic RNA (neg-RNA) and the presence of positive sense RNA (pos-RNA), including both replication intermediate (antigenomic-RNA) and messenger RNA (mRNA) molecules, in the upper and lower respiratory tract, as compared to plasma, in a HCW infected with EBOV in Sierra Leone, who was hospitalized in the high isolation facility of the National Institute for Infectious Diseases "Lazzaro Spallanzani" (INMI), Rome, Italy...
January 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28053360/countries-response-to-who-s-travel-recommendations-during-the-2013-2016-ebola-outbreak
#15
Wendy Rhymer, Rick Speare
OBJECTIVE: To determine how, during the 2013-2016 Ebola outbreak in western Africa, States Parties to the World Health Organization's (WHO) 2005 International Health Regulations (IHR) followed the IHR's international travel recommendations. METHODS: In 2015, we used the Google search engine to investigate the 196 States Parties to the 2005 IHR. Information detailing Ebola-related travel regulations or restrictions of each State Party was sourced first from official government websites and then from travel and news websites...
January 1, 2017: Bulletin of the World Health Organization
https://www.readbyqxmd.com/read/28052985/experiences-of-using-life-histories-with-health-workers-in-post-conflict-and-crisis-settings-methodological-reflections
#16
Sophie Witter, Justine Namakula, Alvaro Alonso-Garbayo, Haja Wurie, Sally Theobald, Wilson Mashange, Bandeth Ros, Stephen Buzuzi, Richard Mangwi, Tim Martineau
INTRODUCTION: Life history is a research tool which has been used primarily in sociology and anthropology to document experiences of marginalized individuals and communities. It has been less explored in relation to health system research. In this paper, we examine our experience of using life histories to explore health system trajectories coming out of conflict through the eyes of health workers. METHODS: Life histories were used in four inter-related projects looking at health worker incentives, the impact of Ebola on health workers, deployment policies, and gender and leadership in the health sector...
January 4, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/28051966/operational-perspective-of-lessons-learned-from-the-ebola-crisis
#17
Zygmunt F Dembek, Jerry L Mothershead, Tesema Chekol, David B Myers, Ronald G Meris, Dana Meranus, Aiguo Wu
Given its potential to quickly spread internationally and initially uncontrollable nature, the 2014 to 2015 Ebola outbreak has implications for global biosecurity. The Defense Threat Reduction Agency's Technical Reachback provided near real-time analysis and recommendations as outbreak-relevant events unfolded. Our review of often-conflicting or incomplete information was required to answer policy decision makers about the expanding Ebola epidemic, and enable the formulation of best-possible U.S. Department of Defense and Government response...
January 2017: Military Medicine
https://www.readbyqxmd.com/read/28051304/censored-regression-modelling-to-predict-virus-inactivation-in-wastewaters
#18
Julii Brainard, Katherine Pond, Paul R Hunter
Among the many uncertainties presented by poorly studied pathogens is possible transmission via human faecal material or wastewaters. Such worries were a documented concern during the 2013 Ebola outbreak in West Africa. Using published experimental data on virus inactivation rates in wastewater and similar matrices, we extracted data to construct a model predicting the T90 (1 x log10 inactivation measured in seconds) of a virus. Extracted data were: RNA or DNA genome, enveloped or not, primary transmission pathway, temperature, pH, light levels and matrix...
January 4, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28050868/field-assessment-of-the-new-rapid-diagnostic-test-ebola-ezyscreen-%C3%A2
#19
F Gallais, F Gay-Andrieu, V Picot, N Magassouba, S Mély, C N Peyrefitte, L Bellanger
During the Ebola virus disease outbreak in West Africa in 2014, the World Health Organization has pointed out the need for rapid diagnostic tests (RDT) affordable, sensitive, specific, user-friendly, rapid, equipment-free, and deliverable. The rapid diagnostic test (Lateral Flow Assay) Ebola eZYSCREEN(®) was developed in this emergency frame using monoclonal antibodies against the envelope glycoprotein of the virus. Two distinct versions have been industrialized, one for whole-blood samples and the other for serum/plasma samples...
January 3, 2017: Bulletin de la Société de Pathologie Exotique
https://www.readbyqxmd.com/read/28049495/the-link-between-the-west-african-ebola-outbreak-and-health-systems-in-guinea-liberia-and-sierra-leone-a-systematic-review
#20
REVIEW
Haitham Shoman, Emilie Karafillakis, Salman Rawaf
BACKGROUND: An Ebola outbreak started in December 2013 in Guinea and spread to Liberia and Sierra Leone in 2014. The health systems in place in the three countries lacked the infrastructure and the preparation to respond to the outbreak quickly and the World Health Organisation (WHO) declared a public health emergency of international concern on August 8 2014. OBJECTIVE: The aim of this study was to determine the effects of health systems' organisation and performance on the West African Ebola outbreak in Guinea, Liberia and Sierra Leone and lessons learned...
January 4, 2017: Globalization and Health
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