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https://www.readbyqxmd.com/read/29768938/double-blind-placebo-controlled-randomized-clinical-trial-of-ginger-zingiber-officinale-rosc-addition-in-migraine-acute-treatment
#1
Laís Bhering Martins, Ana Maria Dos Santos Rodrigues, Débora Fernandes Rodrigues, Luana Caroline Dos Santos, Antônio Lúcio Teixeira, Adaliene Versiani Matos Ferreira
Background Previous studies have demonstrated the analgesic effects of ginger in different conditions, but evidence about its efficacy in migraine treatment is scarce. Objective This study aimed to evaluate the potential of ginger to improve acute migraine as an add-on strategy to standard treatment. Methods A double-blind placebo-controlled randomized clinical trial in the emergency room of a general hospital was conducted. Patients who sought medical care at the time of migraine attack were enrolled in this study...
January 1, 2018: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/29765659/self-assembly-behaviours-of-peptide-drug-conjugates-influence-of-multiple-factors-on-aggregate-morphology-and-potential-self-assembly-mechanism
#2
Qin Fan, Yujie Ji, Jingjing Wang, Li Wu, Weidong Li, Rui Chen, Zhipeng Chen
Peptide-drug conjugates (PDCs) as self-assembly prodrugs have the unique and specific features to build one-component nanomedicines. Supramolecular structure based on PDCs could form various morphologies ranging from nanotube, nanofibre, nanobelt to hydrogel. However, the assembly process of PDCs is too complex to predict or control. Herein, we investigated the effects of extrinsic factors on assembly morphology and the possible formation of nanostructures based on PDCs. To this end, we designed a PDC consisting of hydrophobic drug ( S )-ketoprofen (Ket) and valine-glutamic acid dimeric repeats peptide (L-VEVE) to study their assembly behaviour...
April 2018: Royal Society Open Science
https://www.readbyqxmd.com/read/29763781/inhibition-of-vegf-gene-expression-in-osteoblast-cells-by-different-nsaids
#3
Francisco Javier Manzano-Moreno, Victor Javier Costela-Ruiz, Lucía Melguizo-Rodríguez, Rebeca Illescas-Montes, Olga García-Martínez, Concepción Ruiz, Javier Ramos-Torrecillas
OBJECTIVE: To determine the effect of different nonsteroidal anti-inflammatory drugs (NSAIDs) on vascular endothelial growth factor (VEGF) gene expression in two osteoblast cell populations. DESIGN: Osteoblasts obtained by primary culture (HOp) and human osteosarcoma cell line MG63 (MG-63), which were treated with 10 μM doses of acetaminophen, indomethacin, ketoprofen, diclofenac, ibuprofen, ketorolac, naproxen or piroxicam. At 24 h of treatment, their gene expression of VEGF was evaluated by real-time polymerase chain reaction (RT-PCR) and compared with the expression in untreated cells (control group)...
May 9, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/29759249/in-line-carbon-nanofiber-reinforced-hollow-fiber-mediated-liquid-phase-microextraction-using-a-3d-printed-extraction-platform-as-a-front-end-to-liquid-chromatography-for-automatic-sample-preparation-and-analysis-a-proof-of-concept-study
#4
Chanatda Worawit, David J Cocovi-Solberg, Pakorn Varanusupakul, Manuel Miró
A novel concept for automation of nanostructured hollow-fiber supported microextraction, combining the principles of liquid-phase microextraction (LPME) and sorbent microextraction synergically, using mesofluidic platforms is proposed herein for the first time, and demonstrated with the determination of acidic drugs (namely, ketoprofen, ibuprofen, diclofenac and naproxen) in urine as a proof-of-concept applicability. Dispersed carbon nanofibers (CNF) are immobilized in the pores of a single-stranded polypropylene hollow fiber (CNF@HF) membrane, which is thereafter accommodated in a stereolithographic 3D-printed extraction chamber without glued components for ease of assembly...
August 1, 2018: Talanta
https://www.readbyqxmd.com/read/29759229/evaluation-of-polar-organic-chemical-integrative-and-hollow-fibre-samplers-for-the-determination-of-a-wide-variety-of-organic-polar-compounds-in-seawater
#5
Leire Mijangos, Haizea Ziarrusta, Ailette Prieto, Oihane Zugazua, Olatz Zuloaga, Maitane Olivares, Aresatz Usobiaga, Albrecht Paschke, Nestor Etxebarria
The calibration of two passive samplers for the determination of 20 emerging organic compounds in seawater is described in this work: i) a new version of polar organic chemical integrative sampler (POCIS) containing 100 mg of mixed-mode anion exchanger (Strata X-AW) and 100 mg of polymeric HLB (Plexa) sorbent materials and using a highly porous Nylon membrane (30-μm pore size) and ii) polyethersulfone (PES) hollow fibre. Among the studied contaminants, herbicides, hormones, life style products (stimulants and artificial sweeteners), industrial chemicals (corrosion inhibitor and fluorinated compounds), personal care products and several pharmaceuticals were included...
August 1, 2018: Talanta
https://www.readbyqxmd.com/read/29755544/physicochemical-stress-degradation-evaluation-and-pharmacokinetic-study-of-azgh101-a-new-synthesized-cox2-inhibitor-after-i-v-and-oral-administration-in-male-and-female-rats
#6
Hoda Bahmanof, Simin Dadashzadeh, Afshin Zarghi, Alireza Shafaati, Seyed Mohsen Foroutan
Nonsteroidal anti-inflammatory drugs (NSAIDs) act mainly via inhibition of prostaglandins synthesis by inhibition of cyclooxygenase (COX) isoenzymes (COX-1 and COX-2). Selective COX-2 inhibitors which are also known as coxibs provide the main therapeutic effects of NSAIDs. Zarghi et al . reported 6-benzoyl-2-(4-(methylsulfonyl) phenyl) quinoline-4-carboxylic acid (AZGH101) as a novel derivative of ketoprofen with improved selectivity index (COX-1/COX-2 inhibitory potency) in comparison with ketoprofen. In this study, the log P and stability of AZGH101 were evaluated and the pharmacokinetic characteristics of this compound were investigated following intravenous (10 mg/kg), and oral administration (20 mg/kg), to Wistar rats...
2018: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/29751415/seasonal-and-ageing-effect-on-the-behaviour-of-86-drugs-in-a-full-scale-surface-treatment-wetland-removal-efficiencies-and-distribution-in-plants-and-sediments
#7
Maximilien Nuel, Julien Laurent, Paul Bois, Dimitri Heintz, Adrien Wanko
The presence of human drugs in the aquatic environment is partly due to an incomplete and insufficient removal process of wastewater treatment plants (WWTPs). Thus, drug traces are observed at different concentrations in water bodies, sediments and aquatic plants all over the world. At the same time, Surface Flow Treatment Wetlands (SFTWs) at the outlet of WWTPs are commonly observed in small municipalities as complementary treatment. However, little is known regarding the role of SFTWs in the complementary mitigation of emerging contaminants, such as drugs, and the interactions between drugs, plants and sediment throughout the seasons...
February 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29746127/discovery-of-novel-nonsteroidal-anti-inflammatory-drugs-and-carbonic-anhydrase-inhibitors-hybrids-nsaids-cais-for-the-management-of-rheumatoid-arthritis
#8
Ozlem Akgul, Lorenzo Di Cesare Mannelli, Daniela Vullo, Andrea Angeli, Carla Ghelardini, Gianluca Bartolucci, Abdulmalik Saleh Alfawaz Altamimi, Andrea Scozzafava, Claudiu T Supuran, Fabrizio Carta
Herein we report the design as well as the synthesis of a new series of dual hybrid compounds consisting of the therapeutically used Nonsteroidal-Anti-Inflammatory Drugs (NSAIDs ;i.e. indometacin, sulindac, ketoprofen, ibuprofen, diclofenac, ketorolac, etc., cyclooxygenase inhibitors) and the Carbonic Anhydrase Inhibitor (CAIs) fragments of the sulfonamide type. Such compounds are proposed as new tools for the management of ache symptoms associated to rheumatoid arthritis (RA) and related inflammation diseases...
May 10, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29729862/a-comprehensive-study-of-a-new-versatile-microchip-device-based-liquid-phase-microextraction-for-stopped-flow-and-double-flow-conditions
#9
María Ramos Payán, Elia Santigosa Murillo, Jordi Coello, Miguel Ángel Bello López
A new geometry for a versatile microfluidic-chip device based liquid phase microextraction was developed in order to enhance the preconcentration in microfluidic chips and also to enable double-flow and stopped-flow working modes. The microchip device was combined with a HPLC procedure for the simultaneous determination of two different families as model analytes, which were parabens and non-steroidal anti-inflammatories (NSAIDs): Ethyl 4-hydroxybenzoate (Et-P), Propyl 4-hydroxybenzoate (Pr-P), Butyl 4-hydroxybenzoate (Bu-P), IsoButyl 4-hydroxybenzoate (iBu-P), salycilic acid (SAC), ketoprofen (KET), naproxen (NAX), diclofenac (DIC) and ibuprofen (IBU) in urine samples...
April 30, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29710617/illicit-drugs-and-pharmaceuticals-in-swimming-pool-waters
#10
G Fantuzzi, G Aggazzotti, E Righi, G Predieri, S Castiglioni, F Riva, E Zuccato
The occurrence of illicit drugs (cocaine, opioids, amphetamines and cannabis derivatives), some of their metabolites and 48 pharmaceuticals, was investigated in pool and source waters in ten Italian indoor swimming pools. The samples were analyzed by highperformance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS), after solid phase extraction (SPE). Cocaine and its metabolites were found in nine swimming pools, at concentrations from 0.3 to 4.2 ng/L for cocaine, 1.1 to 48.7 ng/L for norcocaine, 0...
April 20, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29705907/impact-of-selected-drugs-and-their-binary-mixtures-on-the-germination-of-sorghum-bicolor-sorgo-seeds
#11
Monika Wieczerzak, Błażej Kudłak, Jacek Namieśnik
The aim of this study was to assess the toxicological potential of binary drug mixtures and individual drugs under different pH conditions with different inorganic ion additions on the germination of Sorghum bicolor (sorgo) seeds. To assess whether the given drug mixtures were more phytotoxic than the individual compounds, concentration addition (CA) and independent action (IA) approaches were applied to estimate the predicted phytotoxicity values, followed by calculations of the MDR (model deviation factor) to determine the deviation from the predicted values...
April 29, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29704783/detection-of-bisphenol-a-in-aqueous-medium-by-screen-printed-carbon-electrodes-incorporating-electrochemical-molecularly-imprinted-polymers
#12
Vitalys Mba Ekomo, Catherine Branger, Raphaël Bikanga, Ana-Mihaela Florea, Georges Istamboulie, Carole Calas-Blanchard, Thierry Noguer, Andrei Sarbu, Hugues Brisset
Electrochemical molecularly imprinted polymers (e-MIPs) were for the first time introduced in screen-printed carbon electrodes (SPCE) as the sensing element for the detection of an organic pollutant. To play this sensing role, a redox tracer was incorporated inside the binding cavities of a cross-linked MIP, as a functional monomer during the synthesis step. Ferrocenylmethyl methacrylate was used for this purpose. It was associated with 4-vinylpyridine as a co-functional monomer and ethylene glycol dimethacrylate as cross-linker for the recognition of the endocrine disruptor, Bisphenol A (BPA), as a target...
April 21, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29702595/optical-detection-of-ketoprofen-by-its-electropolymerization-on-an-indium-tin-oxide-coated-optical-fiber-probe
#13
Robert Bogdanowicz, Paweł Niedziałkowski, Michał Sobaszek, Dariusz Burnat, Wioleta Białobrzeska, Zofia Cebula, Petr Sezemsky, Marcin Koba, Vitezslav Stranak, Tadeusz Ossowski, Mateusz Śmietana
In this work an application of optical fiber sensors for real-time optical monitoring of electrochemical deposition of ketoprofen during its anodic oxidation is discussed. The sensors were fabricated by reactive magnetron sputtering of indium tin oxide (ITO) on a 2.5 cm-long core of polymer-clad silica fibers. ITO tuned in optical properties and thickness allows for achieving a lossy-mode resonance (LMR) phenomenon and it can be simultaneously applied as an electrode in an electrochemical setup. The ITO-LMR electrode allows for optical monitoring of changes occurring at the electrode during electrochemical processing...
April 27, 2018: Sensors
https://www.readbyqxmd.com/read/29685034/nano-structures-in-n-octanol-equilibrated-with-additives-and-or-water
#14
Gregor Cevc, Ida Berts, Stefan F Fischer, Joachim O Rädler, Bert Nickel
Fluid fatty alcohols are believed to be nanostructured but broadly amorphous, i.e. non-crystalline, fluids and solvents, including the most popular fatty tissue mimetic: hydrated n-octanol (i.e., hydro-octanol). To check this premise, we studied dry octanol and hydro-octanol, as a model of relatively short fluid n-alkanols, with small angle X- rays scattering (SAXS). We also combined this alkanol with the matching alkane (i.e., octane) and with a common anti-inflammatory pain-killer, ketoprofen. This revealed that (hydro)octanol, and arguably any other short fatty alcohol, forms a mesophase...
April 24, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29668764/population-scale-retrospective-analysis-reveals-distinctive-antidepressant-and-anxiolytic-effects-of-diclofenac-ketoprofen-and-naproxen-in-patients-with-pain
#15
Tigran Makunts, Isaac V Cohen, Kelly C Lee, Ruben Abagyan
Currently approved monoamine modulating antidepressant and anxiolytic pharmaceutics fail in over one third of patients due to delayed and variable therapeutic effect, adverse reactions preceding the therapeutic action, and adherence issues. Even with adequate adherence to the regimen and tolerability, one third of the patients do not respond to any class of antidepressants. There is a strong correlation between treatment resistant depression and increase in inflammatory cytokines in plasma and cerebrospinal fluid...
2018: PloS One
https://www.readbyqxmd.com/read/29665554/inhibition-by-non-steroidal-anti-inflammatory-drugs-of-compound-action-potentials-in-frog-sciatic-nerve-fibers
#16
Rika Suzuki, Tsugumi Fujita, Kotaro Mizuta, Eiichi Kumamoto
AIMS: Although antinociception produced by non-steroidal anti-inflammatory drugs (NSAIDs) is partly attributed to nerve conduction inhibition, this has not been thoroughly examined yet. The aim of the present study was to reveal quantitatively how various types of NSAIDs affect compound action potentials (CAPs), a measure of nerve conduction. MAIN METHODS: CAPs were recorded from the frog sciatic nerve by using the air-gap method. KEY FINDINGS: Soaking the sciatic nerve with acetic acid-based NSAIDs (diclofenac and aceclofenac) reduced the peak amplitude of CAP in a concentration-dependent manner; their IC50 values were 0...
April 14, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29651679/biodegradable-ingredient-based-emulgel-loaded-with-ketoprofen-nanoparticles
#17
Rabia Gul, Naveed Ahmed, Naseem Ullah, Muhammad Ijaz Khan, Abdelhamid Elaissari, Asim Ur Rehman
Biodegradable materials are extensively employed to design nanocarriers that mimic extracellular environment in arthritis. The aim of this study was to formulate and characterize biocompatible, biodegradable ketoprofen-loaded chitosan-chondroitin sulfate (CHS-CS) nanoparticles with natural ingredients for transdermal applications. Polymers used in the design of nanocarriers are biodegradable and produce synergistic anti-inflammatory effect for the treatment of arthritis. For transdermal application, argan oil-based emulgel is utilized to impart viscosity to the formulation...
April 12, 2018: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29626791/biotransformation-and-oxidative-stress-responses-in-rat-hepatic-cell-line-h4iie-exposed-to-racemic-ketoprofen-rs-kp-and-its-enantiomer-dexketoprofen-s-kp
#18
Elvira Mennillo, Åse Krøkje, Carlo Pretti, Valentina Meucci, Augustine Arukwe
Pharmaceuticals such as racemate ketoprofen (RS-KP) and its enantiomer, dexketoprofen (S(+)-KP) are highly detectable non-steroidal anti-inflammatory drugs (NSAIDs) in the aquatic environment and therefore are designated as one of the most emerging groups of pollutants that can affect environmental and human health. The potential impact of these pharmaceuticals was assessed for the first time in vitro using a rat hepatocellular carcinoma cell line (H4IIE). Cells were exposed to low and high concentrations of these drugs...
March 30, 2018: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29624535/comparison-of-intraoperative-sedation-with-dexmedetomidine-versus-propofol-on-acute-postoperative-pain-in-total-knee-arthroplasty-under-spinal-anesthesia-a-randomized-trial
#19
Hyun-Jung Shin, Sang-Hwan Do, Jae-Sung Lee, Tae-Kyun Kim, Hyo-Seok Na
BACKGROUND: In patients undergoing total knee arthroplasty under spinal anesthesia, we compared the postoperative analgesic effect of intraoperative sedation with dexmedetomidine versus propofol. We hypothesized that sedation with dexmedetomidine would result in lower postoperative opioid analgesic consumption than with propofol. METHODS: Forty-eight patients were enrolled and randomly assigned to either a dexmedetomidine group (n = 24), which received a loading dose of 1 μg/kg dexmedetomidine over 10 minutes, followed by a continuous infusion of 0...
April 5, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29607510/analgesic-effect-of-s-flurbiprofen-plaster-in-a-rat-model-of-knee-arthritis-analysis-of-gait-and-synovial-fluid-prostaglandin-e-2-levels
#20
Ayaka Fukumoto, Kyoko Tajima, Miyuki Hori, Yoshihisa Toda, Shinsuke Kaku, Hideo Matsumoto
OBJECTIVES: We developed S (+)-flurbiprofen plaster (SFPP), a novel NSAID patch containing S (+)-flurbiprofen (SFP), a potent cyclooxygenase (COX) inhibitor. The purpose of this study was to assess efficacy of SFPP by analysing its effect on the gait disturbance and measuring the prostaglandin E2 (PGE2 ) production in synovial fluid in a rat model of knee arthritis. METHODS: Knee inflammation was induced in rats by intra-articular injection of a yeast suspension...
April 1, 2018: Journal of Pharmacy and Pharmacology
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