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https://www.readbyqxmd.com/read/29154881/influence-of-polymer-ratio-and-surfactants-on-controlled-drug-release-from-cellulosic-microsponges
#1
Yasser Shahzad, Sidra Saeed, Muhammad Usman Ghori, Tariq Mahmood, Abid Mehmood Yousaf, Muhammad Jamshaid, Rizwan Sheikh, Syed A A Rizvi
Microsponge refers to a highly cross-linked particle system with a capacity to adsorb (like a dry sponge) pharmaceutical materials. There are various methods available to prepare microsponge formulations, in this study we used quasi emulsion-solvent diffusion method with a combination of hydrophobic (ethyl cellulose) and hydrophilic polymers (hydroxypropyl methylcellulose) mediated via Tween 80 and polyvinyl alcohol. Various ratios and amounts of the polymers and surfactants were used to prepare microsponge formulations using ketoprofen as a model drug and extensively characterised...
November 14, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29131239/effectiveness-of-a-novel-boswellic-acids-delivery-form-casperome%C3%A2-in-the-management-of-grade-ii-ankle-sprains-due-to-sport-trauma-a-registry-study
#2
B Feragalli, E Ippolito, M Dugall, M Cacchio, G Belcaro, M R Cesarone, M Abdel-Tawab, A Riva, S Togni, R Eggenhoffner, L Giacomelli
OBJECTIVE: In this study, we evaluated a novel delivery form of boswellic acids (Casperome®) in the management of signs and symptoms associated with ankle sprain grade II due to sport trauma. PATIENTS AND METHODS: In this supplement registry study, 72 otherwise healthy subjects with grade II ankle sprain induced by sport activities were advised to either follow a standard management (SM, 37 subjects) for the condition or the SM with the additional daily intake of 1 tablet containing 250 mg Casperome® (35 subjects)...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29127620/potential-of-the-strain-raoultella-sp-kdf8-for-removal-of-analgesics
#3
Andrea Palyzová, Jiří Zahradník, Helena Marešová, Lucie Sokolová, Eva Kyslíková, Michal Grulich, Václav Štěpánek, Tomáš Řezanka, Pavel Kyslík
The bacterial strain KDF8 capable of growth in the presence of diclofenac and codeine analgesics was obtained after chemical mutagenesis of nature isolates from polluted soils. The strain KDF8 was identified as Raoultella sp. based on its morphology, biochemical properties, and 16S rRNA gene sequence. It was deposited in the Czech Collection of Microorganisms under the number CCM 8678. A growing culture efficiently removed diclofenac (92% removal) and partially also codeine (about 30% degradation) from culture supernatants within 72 h at 28 °C...
November 11, 2017: Folia Microbiologica
https://www.readbyqxmd.com/read/29124963/relevance-and-bio-catalytic-strategies-for-the-kinetic-resolution-of-ketoprofen-towards-dexketoprofen
#4
María Victoria Toledo, Laura Estefanía Briand
This review presents the most relevant investigations concerning the biocatalytic kinetic resolution of racemic ketoprofen to dexketoprofen for the last 22 years. The advantages related to the administration of the dex-enantiomer in terms of human health, the so called "chiral switch" in the pharmaceutical industry and the sustainability of biotransformations have been the driving forces to develop innovative technology to obtain dexketoprofen. In particular, the kinetic resolution of racemic ketoprofen through enantiomeric esterification and hydrolysis using lipases as biocatalysts are thoroughly revised and commented upon...
November 10, 2017: Critical Reviews in Biotechnology
https://www.readbyqxmd.com/read/29104055/improving-the-direct-penetration-into-tissues-underneath-the-skin-with-iontophoresis-delivery-of-a-ketoprofen-cationic-prodrug
#5
Shabbir Lobo, Guang Yan
Current topical nonsteroidal anti-inflammatory drugs (NSAIDs) showed marginal efficacy in treatment of musculoskeletal disorders due to their fast clearance by skin blood flow and thus little direct penetration into the underlying muscle and joint tissues. Using ketoprofen (Kt) as a model NSAID and converting it to a cationic ester prodrug ketoprofen choline chloride (KCC), this study was to investigate the iontophoresis delivery of the prodrug KCC for improving the drug retention in the skin and the direct penetration into underlying tissues...
November 14, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29102060/multifunctionalized-mesoporous-silica-as-an-efficient-reversed-phase-anion-exchange-mixed-mode-sorbent-for-solid-phase-extraction-of-four-acidic-nonsteroidal-anti-inflammatory-drugs-in-environmental-water-samples
#6
Yun Li, Chaonan Huang, Jiajia Yang, Junyu Peng, Jing Jin, Huilian Ma, Jiping Chen
A mesoporous silica Santa Barbara Amorphous-15 (SBA-15) has been first functionalized with 3-[2-(2-aminoethylamino)ethylamino]propyl-trimethoxysilane (a silane with three amines) and then reacted with an excess of phenyl glycidyl ether to generate a mixed-mode anion-exchanger containing both anion-exchange (three amines) and reversed-phase (multiple ether-linked phenyls) functionalities in a single branched ligand. The resulting material has been characterized by scanning electron microscopy, transmission electron microscopy, nitrogen adsorption-desorption measurements, Fourier-transform infrared spectroscopy, and elemental analysis...
October 23, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29092677/cooperativity-effect-involving-drug-dna-rna-intermolecular-interaction-a-b3lyp-d3-and-mp2-theoretical-investigation-on-ketoprofen%C3%A2-%C3%A2-%C3%A2-cytosine%C3%A2-%C3%A2-%C3%A2-h2o-system
#7
Jun-Ping Zhen, Xiao-Chun Wei, Wen-Jing Shi, Zhu-Yuan Huang, Bo Jin, Yu-Kun Zhou
In order to examine the origin of the drug action and design new DNA/RNA-targeted drugs, the cooperativity effect involving drug-DNA/RNA intermolecular interaction in ketoprofen∙∙∙cytosine∙∙∙H2O ternary system were investigated by the B3LYP, B3LYP-D3 and MP2 methods with the 6-311++G(2d,p) basis set. The thermodynamic cooperativity was also evaluated at 310.15 K. The N-H∙∙∙O, O-H∙∙∙O, O-H∙∙∙N, C-H∙∙∙N, and C-H∙∙∙O H-bonds coexist in ternary complexes. The intermolecular interactions obtained by B3LYP-D3 are close to those calculated by MP2...
November 1, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29072664/-the-application-of-different-non-steroidal-anti-inflammatory-drugs-for-the-elimination-of-pain-syndrome-during-the-early-postoperative-period-in-the-children-following-the-surgical-interventions-on-palatine-tonsils
#8
E P Karpova, D A Tulupov, F A Fedotov
The present clinical study included 120 children at the age varying from 6 to 18 tears who had undergone radiowave tonsillotomy followed by symptomatic therapy during the early postoperative period with the application of different non-steroidal anti-inflammatory drugs. All the patients were randomly allocated to four groups each comprised of the equal number of patients. Those of group 1 were treated with ketoprofen lysine salt (КLS) in the form of a solution for oral intake in case of complaints of severe pain in the throat...
2017: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/29057479/ketoprofen-pharmacokinetics-of-r-and-s-isomers-in-juvenile-loggerhead-sea-turtles-caretta-caretta-after-single-intravenous-and-single-and-multidose-intramuscular-administration
#9
K A Thompson, M G Papich, B Higgins, J Flanagan, E F Christiansen, C A Harms
Ketoprofen is a nonsteroidal anti-inflammatory and analgesic agent that nonselectively inhibits cyclooxygenase, with both COX-1 and COX-2 inhibition. Recent studies on COX receptor expression in reptiles suggest that nonselective COX inhibitors may be more appropriate than more selective inhibitors in some reptiles, but few pharmacokinetic studies are available. The goal of this study was to determine single- and multidose (three consecutive days) pharmacokinetics of racemic ketoprofen administered intravenously and intramuscularly at 2 mg/kg in healthy juvenile loggerhead turtles (Caretta caretta)...
October 22, 2017: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29056774/glucocorticoid-management-in-rheumatoid-arthritis-morning-or-night-low-dose
#10
REVIEW
Sabrina Paolino, Maurizio Cutolo, Carmen Pizzorni
Morning symptoms of rheumatoid arthritis (RA) are linked to circadian increase of night inflammation, supported by inadequate cortisol secretion in active disease. Therefore, exogenous glucocorticoid administration in RA is recommended by EULAR and ACR from the beginning of the diagnosis, since may partially act like a "replacement therapy". In addition, the prevention/treatment of the night up-regulation of the immune/inflammatory reaction has been shown more effective when exogenous glucocorticoid administration is managed with a night-time-release formulation...
2017: Reumatologia
https://www.readbyqxmd.com/read/29054373/from-concept-to-in-vivo-testing-microcontainers-for-oral-drug-delivery
#11
Chiara Mazzoni, Fabio Tentor, Sophie Andersen Strindberg, Line Hagner Nielsen, Stephan Sylvest Keller, Tommy Sonne Alstrøm, Carsten Gundlach, Anette Müllertz, Paolo Marizza, Anja Boisen
This work explores the potential of polymeric micrometer sized devices (microcontainers) as oral drug delivery systems (DDS). Arrays of detachable microcontainers (D-MCs) were fabricated on a sacrificial layer to improve the handling and facilitate the collection of individual D-MCs. A model drug, ketoprofen, was loaded into the microcontainers using supercritical CO2 impregnation, followed by deposition of an enteric coating to protect the drug from the harsh gastric environment and to provide a fast release in the intestine...
October 18, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29048490/a-simple-method-for-the-simultaneous-determination-of-pharmaceuticals-and-personal-care-products-in-river-sediment-by-ultrasound-assisted-extraction-followed-by-solid-phase-microextraction-coupled-with-gas-chromatography-mass-spectrometry
#12
Alejandro Díaz, Araceli Peña-Alvarez
A simple method was developed using ultrasound-assisted extraction (UAE) combined with solid-phase microextraction (SPME) coupled with gas chromatography-mass spectrometry (GC-MS) for the simultaneous determination of eight different pharmaceuticals and personal care products (PPCPs) (ibuprofen, 2-benzyl-4-chlorophenol, naproxen, triclosan, ketoprofen, diclofenac, bisphenol A and estrone) in river sediment. UAE conditions were optimized involving extraction variables such as extraction solvent, extraction time, sample amount, extraction temperature, pH and salt addition...
October 1, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/29043859/gastrointestinal-bleeding-associated-with-chronic-excessive-use-overdosing-with-topical-ketoprofen-patch-in-elderly-patient
#13
Sakiko Hirose, Kana Matsuura, Hiroko Kato-Hayashi, Akio Suzuki, Koichi Ohata, Ryo Kobayashi, Takashi Ibuka, Hiroshi Araki, Masahito Shimizu, Yoshinori Itoh
PURPOSE: Topical ketoprofen patch has been developed to reduce the risk of systemic adverse effects such as gastrointestinal injury and renal toxicity. MATERIALS AND METHODS: We reported here a case of lower intestinal bleeding associated with chronic excessive use of topical ketoprofen patch in an elderly patient. RESULTS: A 74-year-old female visited to the outpatient clinic of the Gifu University Hospital and admitted thereafter. She had fecal occult blood and anemia...
October 18, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29039320/pharmacokinetic-and-bioequivalence-studies-of-fast-dispersible-ketoprofen-tablets-in-healthy-volunteers
#14
Farya Zafar, Muhammad Harris Shoaib, Rabia Ismail Yousuf, Huma Ali, Rabia Bushra
In the present study the pharmacokinetic and bioequivalence parameter of Ketoprofen 100 mg fast dispersible tablets (test) were measured with marketed (reference) product. This study was accomplished following FDA guidance. A single dose, open labeled, cross over (two way), randomized study design was used to conduct investigation on 12 Pakistani healthy volunteers. At various time points blood samples (10mL) were drawn i.e. at 0.25, 0.5, 1, 1.5, 2, 3, 4, 8, 12 and 13hr. Plasma was then separated and ketoprofen concentrations were estimated by validated HPLC technique using LC 20A pump (Shimadzu Corp, Japan) and Spectrophotometric SPD-20Adetector (Shimadzu Corp, Japan)...
July 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29032095/a-review-on-environmental-monitoring-of-water-organic-pollutants-identified-by-eu-guidelines
#15
REVIEW
João C G Sousa, Ana R Ribeiro, Marta O Barbosa, M Fernando R Pereira, Adrián M T Silva
The contamination of fresh water is a global concern. The huge impact of natural and anthropogenic organic substances that are constantly released into the environment, demands a better knowledge of the chemical status of Earth's surface water. Water quality monitoring studies have been performed targeting different substances and/or classes of substances, in different regions of the world, using different types of sampling strategies and campaigns. This review article aims to gather the available dispersed information regarding the occurrence of priority substances (PSs) and contaminants of emerging concern (CECs) that must be monitored in Europe in surface water, according to the European Union Directive 2013/39/EU and the Watch List of Decision 2015/495/EU, respectively...
October 3, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29026333/analgesic-efficacy-and-safety-of-epidural-oxycodone-in-patients-undergoing-total-hip-arthroplasty-a-pilot-study
#16
Bogumił Olczak, Grzegorz Kowalski, Wojciech Leppert, Agnieszka Bienert, Artur Teżyk, Michał Adamski, Stanisław Rzymski, Katarzyna Wieczorowska-Tobis
BACKGROUND AND OBJECTIVES: Oxycodone is poorly studied as an adjuvant to central blockades. The aim of this pilot study was to assess the efficacy and safety of oxycodone hydrochloride in epidural blockade among patients undergoing total hip arthroplasty (THA). PATIENTS AND METHODS: In 11 patients (American Society of Anesthesiologists physical status classification system II/III, age range: 59-82 years), THA was conducted with an epidural blockade using 15 mL 0...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28991796/continuous-transformation-of-chiral-pharmaceuticals-in-enzymatic-membrane-bioreactors-for-advanced-wastewater-treatment
#17
Luong N Nguyen, Faisal I Hai, James A McDonald, Stuart J Khan, William E Price, Long D Nghiem
This study demonstrates continuous enantiomeric inversion and further biotransformation of chiral profens including ibuprofen, naproxen and ketoprofen by an enzymatic membrane bioreactor (EMBR) dosed with laccase. The EMBR showed non-enantioselective transformations, with high and consistent transformation of both (R)- and (S)-ibuprofen (93 ± 6%, n = 10), but lower removals of both enantiomers of naproxen (46 ± 16%, n = 10) and ketoprofen (48 ± 17%, n = 10). Enantiomeric analysis revealed a bidirectional but uneven inversion of the profens, for example 14% inversion of (R)- to (S)- compared to 4% from (S)- to (R)-naproxen...
October 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28987537/tuning-the-rheological-properties-of-an-ammonium-methacrylate-copolymer-for-the-design-of-adhesives-suitable-for-transdermal-patches
#18
Gaia M G Quaroni, Chiara G M Gennari, Francesco Cilurzo, Guylaine Ducouret, Costantino Creton, Paola Minghetti
Eudragit® RL (EuRL) matrices have been proposed to release a drug to the skin. However, no information is available on both viscoelastic and adhesive properties of such compositions. This work focuses on the evaluation of both rheological and texture properties of EuRL differently plasticized with tributyl citrate (TBC) or triacetin (TRI) in order to design a pressure sensitive adhesive suitable for transdermal patch preparation. The patch adhesive properties (i.e. tack, peel adhesion and shear adhesion) as well as its in vitro biopharmaceutical performances were determined after loading ibuprofen, ketoprofen or flurbiprofen...
October 5, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28966257/recombinant-human-serum-albumin-containing-3-copies-of-domain-i-has-significant-in-vitro-antioxidative-capacity-compared-to-the-wild-type
#19
Sadaharu Matsushita, Koji Nishi, Yasunori Iwao, Yu Ishima, Hiroshi Watanabe, Kazuaki Taguchi, Keishi Yamasaki, Toru Maruyama, Masaki Otagiri
Human serum albumin (HSA), the most abundant protein in serum, functions as carrier of drugs and contributes to maintaining serum colloid osmotic pressure. We report herein on the preparation of a genetic recombinant HSA, in which domains II and III were changed to domain I (triple domain I; TDI). Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) results indicated that the purity of the TDI was equivalent to that of the wild type (WT). Both far- and near-UV circular dichroism (CD) spectra of the TDI showed that its structural characteristics were similar to the WT...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28965059/degradation-of-ketoprofen-by-sulfate-radical-based-advanced-oxidation-processes-kinetics-mechanisms-and-effects-of-natural-water-matrices
#20
Yiping Feng, Qingyun Song, Wenying Lv, Guoguang Liu
Ketoprofen (KET) is a mostly used nonsteroidal anti-inflammatory drug that has been frequently detected in wastewater effluents and surface waters. In this study, we investigated the degradation of KET by sulfate radical (SO4(-)) based advanced oxidation processes (SR-AOPs) in aqueous solution. The degradation kinetics, mechanisms, and effects of natural water matrices on thermally activated persulfate (TAP) oxidation of KET were systematically investigated. Increasing the temperature and persulfate (PS) concentrations greatly enhanced the degradation of KET...
September 25, 2017: Chemosphere
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