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https://www.readbyqxmd.com/read/28633956/a-time-adjustable-pulsatile-release-system-for-ketoprofen-in-vitro-and-in-vivo-investigation-in-a-pharmacokinetic-study-and-an-ivivc-evaluation
#1
Haiying Wang, Lizhen Cheng, Haoyang Wen, Caiyan Li, Yuenan Li, Xiaoyu Zhang, Yongfei Wang, Yanyan Wang, Tuanjie Wang, Weisan Pan, Xinggang Yang
A time-adjustable pulsatile release system (TAPS) containing ketoprofen (KF) as an active pharmaceutical agent was developed having been designed for bedtime dosing and releasing drug in the early morning to control the symptoms of rheumatoid arthritis (RA). The formulation involved a tablet core (KF) and a control-release layer, and the coating membrane was composed of EC and Eudragit L100. A single-factor study, a central composite design and a response surface method were selected to optimize the formula and the optimum prescription was as follows: tablet core (KF 50mg, MCC 70mg, lactose 40mg, L-HPC 38mg), and film (EC 7...
June 17, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28603129/pharmaceutical-and-in-vitro-therapeutic-equivalence-studies-of-ketoprofen-enteric-coated-100-mg-tablets
#2
Farya Zafar, Muhammad Harris Shoaib, Huma Ali, Rabia Ismail Yousuf, Ghazala Raza Naqvi, Zebun Nisa, Yusra Shafiq
The objective of this study was to assess the quality of six different brands of enteric coated Ketoprofen 100 mg tablets, KPB2 to KPB6 are available in commercial market of Karachi, Pakistan, while KPB1 was obtained from international source. We performed different physico-chemical assessments i.e. weight variation, diameter, hardness, friability, thickness, disintegration, content uniformity, assay and dissolution test. Results of all the investigations were found to be in adequate limits. Also pharmaceutical equivalence was determined by selecting different tests and assay assessment...
January 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28589306/application-of-a-biodegradable-polyesteramide-derived-from-l-alanine-as-novel-excipient-for-controlled-release-matrix-tablets
#3
Ana Dora Bonillo Martínez, Inés Carmen Rodríguez Galán, María Victoria Margarit Bellver
This pre-formulation study assays the capacity of the polyesteramide PADAS, poly (L-alanine-dodecanediol-L-alanine-sebacic), as an insoluble tablet excipient matrix for prolonged drug release. The flow properties of PADAS were suitable for tableting, and the compressibility of tablets containing exclusively PADAS was evaluated by ESEM observation of the microstructure. The tablets were resistant to crushing and non-friable and they did not undergo disintegration (typical features of an inert matrix). Tablets containing 33...
June 6, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28578813/multiclass-method-for-the-determination-of-pharmaceuticals-and-personal-care-products-in-compost-from-sewage-sludge-using-ultrasound-and-salt-assisted-liquid-liquid-extraction-followed-by-ultrahigh-performance-liquid-chromatography-tandem-mass-spectrometry
#4
A Luque-Muñoz, J L Vílchez, A Zafra-Gómez
An analytical method for the analysis of 16 pharmaceuticals and personal care products in compost from sewage sludge is successfully validated. Ultrasound assisted extraction with a mixture of acetonitrile:ethyl acetate (1:1, v/v) containing 10% (v/v) of acetic acid was carried out. Two cycles of extraction of 10min were applied. A clean-up of the extracts using salt-assisted liquid-liquid extraction (SALLE) was also included. Experimental design was used for the optimization of the main parameters involved in the extraction and cleaned-up steps...
May 26, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28561772/chiral-derivatives-of-xanthones-investigation-of-the-effect-of-enantioselectivity-on-inhibition-of-cyclooxygenases-cox-1-and-cox-2-and-binding-interaction-with-human-serum-albumin
#5
Carla Fernandes, Andreia Palmeira, Inês I Ramos, Carlos Carneiro, Carlos Afonso, Maria Elizabeth Tiritan, Honorina Cidade, Paula C A G Pinto, M Lúcia M F S Saraiva, Salette Reis, Madalena M M Pinto
Searching of new enantiomerically pure chiral derivatives of xanthones (CDXs) with potential pharmacological properties, particularly those with anti-inflammatory activity, has remained an area of interest of our group. Herein, we describe in silico studies and in vitro inhibitory assays of cyclooxygenases (COX-1 and COX-2) for different enantiomeric pairs of CDXs. The evaluation of the inhibitory activities was performed by using the COX Inhibitor Screening Assay Kit. Docking simulations between the small molecules (CDXs; known ligands and decoys) and the enzyme targets were undertaken with AutoDock Vina embedded in PyRx-Virtual Screening Tool software...
May 31, 2017: Pharmaceuticals
https://www.readbyqxmd.com/read/28558906/carbamoylated-azithromycin-incorporated-zirconia-hybrid-monolith-for-enantioseparation-of-acidic-chiral-drugs-using-non-aqueous-capillary-electrochromatography
#6
Shuchi Dixit, Il Seung Lee, Jung Hag Park
Carbamoylated derivatives of two antibiotics, namely, clindamycin phosphate (CLIP) and erythromycin (ERY) were successfully employed as co-precursors, in combination of zirconium tetrabutoxide as a precursor, to prepare chiral organic-zirconia hybrid monoliths (i.e., CLIP-ZHMs and ERY-ZHMs, respectively) via a single-step in-situ sol-gel approach in our previous works. Their superiority over chiral organic-zirconia/silica monoliths, prepared by post-modification approach, in terms of better enantioresolution and enhanced stability inspired us to prepare ZHMs based on an another antibiotic, azithromycin (i...
May 23, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28542002/assessment-of-behavioral-disruption-in-rats-with-abdominal-inflammation-using-visual-cue-titration-and-the-five-choice-serial-reaction-time-task
#7
Thomas J Martin, Tracy J Strassburg, Amanda L Grigg, Susy A Kim, Douglas G Ririe, James C Eisenach
BACKGROUND: Both acute and chronic pain result in a number of behavioral symptoms in patients, including cognitive effects such as decreased attention and working memory. Intraperitoneal administration of dilute lactic acid in rodents has been used to induce abdominal inflammation and produce effects in behavioral assays of both sensory-discriminative and affective pain modalities. METHODS: Intraperitoneal injection of dilute lactic acid was used to study the impact of abdominal inflammation on an operant task requiring sustained visual attention in rats (N = 7 to 15/group) that adapts dynamically to performance ability...
May 25, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28540716/single-dose-oral-ketoprofen-or-dexketoprofen-for-acute-postoperative-pain-in-adults
#8
REVIEW
Helen Gaskell, Sheena Derry, Philip J Wiffen, R Andrew Moore
BACKGROUND: This review is an update of "Single dose oral ketoprofen and dexketoprofen for acute postoperative pain in adults" last updated in Issue 4, 2009. Ketoprofen is a non-selective nonsteroidal anti-inflammatory drug (NSAID) used to treat acute and chronic painful conditions. Dexketoprofen is the (S)-enantiomer, which is believed to confer analgesia. Theoretically dexketoprofen is expected to provide equivalent analgesia to ketoprofen at half the dose, with a consequent reduction in gastrointestinal adverse events...
May 25, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28535462/pharmaceutical-substances-in-ambient-particulates-a-preliminary-assessment
#9
Angelo Cecinato, Paola Romagnoli, Mattia Perilli, Catia Balducci
Till now, no attention has been paid to pharmaceuticals (PCs) in the air, though they are known to affect waters, soils, foods and biota. This paper describes the first attempt to characterize the PC occurrence in the air. Airborne particulates (PM10 or PM2.5 fractions, from Amsterdam, Netherland, Rome and Rende, Italy) were sampled on quartz fiber filter by means of pumping systems operating at medium-volume conditions (16 or 38.5 L min(-1)). The samples were solvent extracted through sonication with a dichloromethane:acetone:methanol mixture and reduced close to dryness; three fractions of the residue were separated through column chromatography; they comprised non polar, low polar and very polar organic compounds, respectively, and PCs were in the third one...
May 18, 2017: Chemosphere
https://www.readbyqxmd.com/read/28531763/beneficial-effect-of-nanoparticles-over-standard-form-of-zinc-oxide-in-enhancing-the-anti-inflammatory-activity-of-ketoprofen-in-rats
#10
Magdalena Olbert, Joanna Gdula-Argasińska, Gabriel Nowak, Tadeusz Librowski
BACKGROUND: Zinc is known as an anti-inflammatory agent. Recent studies demonstrated the usage of zinc ions for enhancing the anti-inflammatory effect of Non-Steroidal Anti-inflammatory Drugs (NSAIDs). METHODS: This study compares the influence of chronic administration of zinc oxide nanoparticles (ZnO-NPs) and zinc oxide standard form (ZnO-S) on the anti-inflammatory and gastric activity of ketoprofen in rats. Both ZnO-S and ZnO-NPs were administered at doses of 7 or 14mg/kg (intraperitoneally (ip) and per os (po)) for 2 weeks followed by single po ketoprofen administration (in three doses: 5, 10, and 20mg/kg)...
February 9, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28502064/optimization-of-water-oil-surfactant-system-for-preparation-of-medium-chain-length-poly-3-hydroxyalkanoates-mcl-pha-incorporated-nanoparticles-via-nanoemulsion-templating-technique
#11
K A Ishak, M Suffian M Annuar, N Ahmad
Polymeric nanoparticles gain a widespread interest in food and pharmaceutical industries as delivery systems that encapsulate, protect, and release lipophilic compounds such as omega-3 fatty acids, fat-soluble vitamins, carotenoids, carvedilol, cyclosporine, and ketoprofen. In this study, medium-chain-length poly-3-hydroxyalkanoate (mcl-PHA)-incorporated nanoparticle was developed via facile organic solvent-free nanoemulsion templating technique. The water content (W/surfactant-to-oil (S/O)), S/O, and Cremophor EL-to-Span 80 (Cremo/Sp80) ratios were first optimized using response surface methodology (RSM) to obtain nanoemulsion template prior to incorporation of mcl-PHA...
May 13, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28497473/topical-analgesics-for-acute-and-chronic-pain-in-adults-an-overview-of-cochrane-reviews
#12
REVIEW
Sheena Derry, Philip J Wiffen, Eija A Kalso, Rae F Bell, Dominic Aldington, Tudor Phillips, Helen Gaskell, R Andrew Moore
BACKGROUND: Topical analgesic drugs are used for a variety of painful conditions. Some are acute, typically strains or sprains, tendinopathy, or muscle aches. Others are chronic, typically osteoarthritis of hand or knee, or neuropathic pain. OBJECTIVES: To provide an overview of the analgesic efficacy and associated adverse events of topical analgesics (primarily nonsteroidal anti-inflammatory drugs (NSAIDs), salicylate rubefacients, capsaicin, and lidocaine) applied to intact skin for the treatment of acute and chronic pain in adults...
May 12, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28496358/analgesic-efficacy-adverse-effects-and-safety-of-oxycodone-administered-as-continuous-intravenous-infusion-in-patients-after-total-hip-arthroplasty
#13
Bogumił Olczak, Grzegorz Kowalski, Wojciech Leppert, Iwona Zaporowska-Stachowiak, Katarzyna Wieczorowska-Tobis
BACKGROUND: Total hip arthroplasty (THA) causes extensive tissue damage and severe pain. This study aimed to assess the analgesic efficacy, adverse effects (AEs), and safety of continuous intravenous (iv) oxycodone infusion with ketoprofen (injected into the iv line) in patients after THA, and to assay serum oxycodone levels. PATIENTS AND METHODS: Fourteen patients, aged 59‒82 years with American Society of Anesthesiologists (ASA) classification I or III, underwent THA with intrathecal analgesia and sedation induced by iv propofol...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28494300/behaviour-of-the-main-nonsteroidal-anti-inflammatory-drugs-in-a-membrane-bioreactor-treating-urban-wastewater-at-high-hydraulic-and-sludge-retention-time
#14
D M González-Pérez, J I Pérez, M A Gómez
The behaviour and removal efficiency of ibuprofen (IBU), diclofenac (DCF), ketoprofen (KPF), and naproxen (NPX) during the real urban wastewater treatment by an experimental full-scale MBR working at high sludge and hydraulic retention time (SRT, HRT) were determined. The MBR worked in denitrification/nitrification conformation at 35.4h of HRT (Q=0.45m(3)/h), 37 d of SRT and a recirculation flow rate of 4Q. The experiments were made under steady-state conditions, reaching a biodegradable organic matter removal higher than 99...
April 26, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28490670/leukotriene-b4-antagonism-ameliorates-experimental-lymphedema
#15
Wen Tian, Stanley G Rockson, Xinguo Jiang, Jeanna Kim, Adrian Begaye, Eric M Shuffle, Allen B Tu, Matthew Cribb, Zhanna Nepiyushchikh, Abdullah H Feroze, Roham T Zamanian, Gundeep S Dhillon, Norbert F Voelkel, Marc Peters-Golden, Jan Kitajewski, J Brandon Dixon, Mark R Nicolls
Acquired lymphedema is a cancer sequela and a global health problem currently lacking pharmacologic therapy. We have previously demonstrated that ketoprofen, an anti-inflammatory agent with dual 5-lipoxygenase and cyclooxygenase inhibitory properties, effectively reverses histopathology in experimental lymphedema. We show that the therapeutic benefit of ketoprofen is specifically attributable to its inhibition of the 5-lipoxygenase metabolite leukotriene B4 (LTB4). LTB4 antagonism reversed edema, improved lymphatic function, and restored lymphatic architecture in the murine tail model of lymphedema...
May 10, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28480594/nanostructured-dpa-mpc-dpa-triblock-copolymer-gel-for-controlled-drug-release-of-ketoprofen-and-spironolactone
#16
Bahaa Azmy, Guy Standen, Petra Kristova, Andrew Flint, Andrew L Lewis, Jonathan P Salvage
OBJECTIVE: Uncontrolled rapid release of drugs can reduce their therapeutic efficacy and cause undesirable toxicity; however, controlled release from reservoir materials helps overcome this issue. The aims of this study were to determine the release profiles of ketoprofen and spironolactone from a pH-responsive self-assembling DPA-MPC-DPA triblock copolymer gel and elucidate underlying physiochemical properties. METHODS: Drug release profiles from DPA50 -MPC250 -DPA50 gel (pH 7...
May 7, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28474616/ketoprofen-induced-photoallergic-dermatitis
#17
REVIEW
Tiffany Yvonne Loh, Philip R Cohen
Drug-induced photosensitivity reactions are significant adverse effects. Ketoprofen is one of the most common drugs that can cause skin rash in sun-exposed areas. Non-steroidal anti-inflammatory drugs (NSAIDs), such as ketoprofen, are often used for a variety of symptoms, including pain and fever. An understanding of the presentation and clinical course of ketoprofen-induced photosensitivity is necessary to correctly diagnose and manage this condition. Ketoprofen-induced photosensitivity reactions usually present as photoallergic dermatitis, which is a cell-mediated immune process...
December 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/28450165/effect-of-guest-drug-character-encapsulated-in-the-cavity-and-intermolecular-spaces-of-%C3%AE-cyclodextrins-on-the-dissolution-property-of-ternary-%C3%AE-cyclodextrin-complex
#18
Nan Liu, Kenjirou Higashi, Keisuke Ueda, Kunikazu Moribe
Various ternary Guest 2/(Guest 1/γ-cyclodextrin (CD)) complexes were prepared using a cogrinding and subsequent heating method, wherein Guest 1 was incorporated in the cavity of γ-CD and Guest 2 was incorporated into the intermolecular spaces between γ-CD columns. Dissolution fluxes of Guest 1 and Guest 2 from all ternary complexes were almost identical. The dissolution flux of flurbiprofen (Guest 1) from the ternary complexes depended on the solubility of Guest 2 drugs (naproxen < ketoprofen < ethenzamide) in the dissolution medium of pH 1...
April 24, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28436310/synthesis-and-characterization-of-poly-n-vinylcaprolactam-based-spray-dried-microparticles-exhibiting-temperature-and-ph-sensitive-properties-for-controlled-release-of-ketoprofen
#19
Simone F Medeiros, Milene V Lopes, Bartira Rossi-Bergmann, Maria Inês Ré, Amilton M Santos
Poly(N-vinylcaprolactam) (PNVCL) and poly(N-vinylcaprolactam-co-acrylic acid) (poly(NVCL-co-AA)) were synthesized by solution-free radical polymerization and displayed thermo-responsive behavior, with lower critical solution temperatures (LCSTs) of 35 °C and 39 °C, respectively. The incorporation of AA unities made the poly(NVCL-co-AA) sensitive to both pH and temperature. They were exploited in this work in preparing microparticles loaded with ketoprofen via spray-drying to modulate the drug release rate by changing pH or temperature...
May 19, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28433767/temporal-dynamics-of-human-excreted-pollutants-in-wastewater-treatment-plant-influents-toward-a-better-knowledge-of-mass-load-fluctuations
#20
Thomas Thiebault, Laëtitia Fougère, Emilie Destandau, Maxime Réty, Jérémy Jacob
The occurrence of 25 drug target residues (illicit drugs or pharmaceutically active compounds) was investigated during 85 consecutive days in the influents of a wastewater treatment plant in the Region Centre-Val de Loire, France. This long tracking period allowed a better understanding of the patterns affecting the occurrence of this type of contaminants. Among them, 2 were never detected (i.e. heroin and amphetamine). Concerning illicit drugs two patterns were found. Cocaine and ecstasy median loads varied considerably between weekdays and weekend days (i...
April 20, 2017: Science of the Total Environment
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