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https://www.readbyqxmd.com/read/29329745/poly-methyl-methacrylate-salt-as-film-forming-material-to-design-orodispersible-films
#1
Umberto M Musazzi, Francesca Selmin, Silvia Franzé, Chiara G M Gennari, Paolo Rocco, Paola Minghetti, Francesco Cilurzo
This work aims to evaluate the possible use of a poly(sodium methacrylate, methyl methacrylate) (NaPMM2) plasticized by PEG400 in design orodispersible films (ODF). Placebo ODF prepared by solvent casting were intended to study the impact of the polymer/plasticizer ratio and residual moisture on disintegration time, stickiness and mechanical properties. The drug loading capacity was assessed using ketoprofen and paracetamol. Placebo ODF containing PEG400 in the 10-30% w/w range and 10-15% of residual moisture content were easy-to-handle, packed without failures and completely dissolved within 30 s...
January 9, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29329564/phytochemical-analysis-antioxidant-and-anti-inflammatory-potential-of-feretia-apodanthera-root-bark-extracts
#2
Oluwayinka Olufunmilayo Owolabi, Dorcas Bolanle James, Ibrahim Sani, Binda T Andongma, Opeoluwa O Fasanya, Barnabas Kure
BACKGROUND: Inflammation has been implicated in many disorders, including cancer and available therapies elicit adverse effects. Plants of the family Rubiaceae have shown potency against inflammation. The anti-inflammatory and anti-oxidant potential of Feretia apodanthera was investigated in this study to evaluate its effectiveness. METHODS: The phytochemical, antioxidant and anti-inflammatory potential of root bark (n-Hexane, diethyl ether, ethanol and aqueous) extracts of Feretia apodanthera was investigated in this study...
January 12, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29327191/iron-impregnated-zeolite-catalyst-for-efficient-removal-of-micropollutants-at-very-low-concentration-from-meurthe-river
#3
Hawraa Ayoub, Thibault Roques-Carmes, Olivier Potier, Bachar Koubaissy, Steve Pontvianne, Audrey Lenouvel, Cédric Guignard, Emmanuel Mousset, Hélène Poirot, Joumana Toufaily, Tayssir Hamieh
In this paper, for the first time, faujasite Y zeolite impregnated with iron (III) was employed as a catalyst to remove a real cocktail of micropollutants inside real water samples from the Meurthe river by the means of the heterogeneous photo-Fenton process. The catalyst was prepared by the wet impregnation method using iron (III) nitrate nonahydrate as iron precursor. First, an optimization of the process parameters was conducted using phenol as model macro-pollutant. The hydrogen peroxide concentration, the light wavelength (UV and visible) and intensity, the iron loading immobilized, as well as the pH of the solution were investigated...
January 11, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29326367/organic-anion-transporter-2-mediates-hepatic-uptake-of-tolbutamide-a-cytochrome-p450-2c9-probe-drug
#4
Yi-An Bi, Sumathy Mathialagan, Laurie Tylaska, Myra Fu, Julie Keefer, Anna Vildhede, Chester Costales, A David Rodrigues, Manthena Varma
Tolbutamide is primarily metabolized by cytochrome P450 (CYP)2C9, and thus, frequently applied as a clinical probe substrate for CYP2C9 activity. However, there is a marked discrepancy in the in vitro-in vivo extrapolation of its metabolic clearance implying potential for additional clearance mechanisms. The goal of this study was to evaluate the role of hepatic uptake transport in the pharmacokinetics of tolbutamide and identify the molecular mechanism thereof. Transport studies using singly-transfected cells expressing six major hepatic uptake transporters showed that tolbutamide is a substrate to organic anion transporter (OAT)2 alone -- with transporter affinity (Km) of 19...
January 11, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29310282/use-of-polymer-inclusion-membranes-pims-as-support-for-electromembrane-extraction-of-non-steroidal-anti-inflammatory-drugs-and-highly-polar-acidic-drugs
#5
Román-Hidalgo Cristina, Martín-Valero María Jesús, Fernández-Torres Rut, Bello-López Miguel Ángel
The use of polymer inclusion membranes (PIMs) as support of 1-octanol liquid membrane in electromembrane extraction (EME) procedure is proposed. Synthesis of PIMs were optimized to a composition of 29% (w/w) of cellulose triacetate as base polymer and 71% (w/w) of Aliquat®336 as cationic carrier. Flat PIMs of 25µm thickness and 6mm diameter were used. EME protocol was implemented for the simultaneous extraction of four non-steroidal anti-inflammatory drugs (NSAIDs) (salicylic acid, ketoprofen, naproxen and ibuprofen) and four highly polar acidic drugs (anthranilic acid, nicotinic acid, amoxicillin and hippuric acid)...
March 1, 2018: Talanta
https://www.readbyqxmd.com/read/29287688/anti-inflammatory-effect-of-atb-352-a-h2s-releasing-ketoprofen-derivative-on-lipopolysaccharide-induced-periodontitis-in-rats
#6
Enrico Gugliandolo, Roberta Fusco, Ramona D'Amico, Angela Militi, Giacomo Oteri, John L Wallace, Rosanna Di Paola, Salvatore Cuzzocrea
Periodontal disease is the most common cause of tooth loss in humans, is an inflammatory disease initiated by oral microbial biofilm. Given the involvement of the inflammatory pathway in this type of pathology, the main pharmacological strategy for the treatment of periodontitis, is the inhibition of the inflammatory process in order to prevent tissue destruction and bone resorption, a condition associated with a painful state. To do this, the best class of drugs are Non-steroidal anti-inflammatory drugs (NSAIDs), however, the presence of side effects, especially at the gastrointestinal tract, limits their use for long-term therapy...
December 26, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29241956/magnetic-sporopollenin-cyanopropyltriethoxysilane-dispersive-micro-solid-phase-extraction-coupled-with-high-performance-liquid-chromatography-for-the-determination-of-selected-non-steroidal-anti-inflammatory-drugs-in-water-samples
#7
Siti Munirah Abd Wahib, Wan Aini Wan Ibrahim, Mohd Marsin Sanagi, Muhammad Afzal Kamboh, Aemi S Abdul Keyon
A facile dispersive-micro-solid phase extraction (D-μ-SPE) method coupled with HPLC for the analysis of selected non-steroidal anti-inflammatory drugs (NSAIDs) in water samples was developed using a newly prepared magnetic sporopollenin-cyanopropyltriethoxysilane (MS-CNPrTEOS) sorbent. Sporopollenin homogenous microparticles of Lycopodium clavatum spores possessed accessible functional groups that facilitated surface modification. Simple modification was performed by functionalization with 3-cyanopropyltriethoxysilane (CNPrTEOS) and magnetite was introduced onto the biopolymer to simplify the extraction process...
November 26, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29233741/cyclooxygenase-enzyme-activity-does-not-impair-respiratory-motor-plasticity-after-one-night-of-intermittent-hypoxia
#8
Adrianne G Huxtable, Elizabeth Kopp, Brendan J Doughtery, Jyoti J Watters, Gordon S Mitchell
Although inflammation is prevalent in many clinical disorders challenging breathing, we are only beginning to understand the impact of inflammation on neural mechanisms of respiratory control. We recently demonstrated one form of respiratory motor plasticity is extremely sensitive to even mild inflammation induced by a single night (8 h) of intermittent hypoxia (IH-1), mimicking aspects of obstructive sleep apnea. Specifically, phrenic long-term facilitation (pLTF) following moderate acute intermittent hypoxia (AIH) is abolished by IH-1, but restored by high doses of the non-steroidal anti-inflammatory drug, ketoprofen...
December 9, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/29227893/targeted-eco-pharmacovigilance-for-ketoprofen-in-the-environment-need-strategy-and-challenge
#9
REVIEW
Jun Wang, Shu-Qi Zhao, Meng-Ya Zhang, Bing-Shu He
Implementing "targeted" eco-pharmacovigilance(EPV) which focuses on individual or specific pharmaceuticals on a prioritised basis is a feasible, economical and customized approach to reduce the environmental concentrations and risks of pharmaceuticals. Non-steroidal anti-inflammatory drugs(NSAIDs) remaining in environment are a kind of priority hazard substances, due to a notable case that diclofenac residues caused the loss of more than 99% of vultures across the Indian sub-continent. Ketoprofen, as another widely used NSAID with comparable or even higher global consumption than diclofenac, in the environment has been shown to present a potential risk to non-target terrestrial and aquatic species...
December 6, 2017: Chemosphere
https://www.readbyqxmd.com/read/29209105/effects-of-nsaids-on-the-release-of-calcitonin-gene-related-peptide-and-prostaglandin-e2-from-rat-trigeminal-ganglia
#10
Vittorio Vellani, Giorgia Moschetti, Silvia Franchi, Chiara Giacomoni, Paola Sacerdote, Giada Amodeo
Nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently used to treat migraine, but the mechanisms of their effects in this pathology are not fully elucidated. The trigeminal ganglia and calcitonin gene-related peptide (CGRP) have been implicated in the pathophysiology of migraine. The release of CGRP and prostaglandin E2 (PGE2) from freshly isolated rat trigeminal ganglia was evaluated after oral administration of nimesulide, etoricoxib, and ketoprofen, NSAIDs with different pharmacological features. Thirty minutes after oral administration, nimesulide, 10 mg/Kg, decreased the GCRP release induced by an inflammatory soup, while the other NSAIDs were ineffective at this point in time...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/29199239/evaluation-of-drug-induced-photosensitivity-using-the-japanese-adverse-drug-event-report-jader-database
#11
Satoshi Nakao, Haruna Hatahira, Sayaka Sasaoka, Shiori Hasegawa, Yumi Motooka, Natsumi Ueda, Junko Abe, Akiho Fukuda, Misa Naganuma, Hiroyuki Kanoh, Mariko Seishima, Motoyuki Ishiguro, Yasutomi Kinosada, Mitsuhiro Nakamura
Drug-induced photosensitivity (DIP) refers to the development of cutaneous disorders caused by the combined effects of different medications and light. The aim of this study was to obtain new information on drug risk comparisons and on DIP onset profiles, including seasonal variations, for clinically used prescription drugs. We analyzed reports of DIP recorded in the Japanese Adverse Drug Event Report (JADER) database using a reporting odds ratio (ROR). We also used Weibull proportional-hazards models for each drug to examine the patterns of DIP...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29174986/correlation-between-glucuronidation-and-covalent-adducts-formation-with-proteins-of-nonsteroidal-anti-inflammatory-drugs
#12
Hiroaki Shimada, Yuri Kobayashi, Sakiko Tanahashi, Atsushi Kawase, Taro Ogiso, Masahiro Iwaki
Nonsteroidal anti-inflammatory drugs (NSAIDs) can cause idiosyncratic liver injury. Mechanisms involved in NSAID-induced liver injury are complex. Previous studies have suggested that acyl glucuronide of NSAIDs (NSAIDs-Glu) plays an important role in the development of liver injury via covalently binds to proteins and the resultant adduct induces immunological toxicity. As only some NSAIDs-Glu are commercially available, the evaluation of covalent protein adduct formation using ready-made NSAIDs-Glu is difficult and inconvenient...
November 22, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29174135/analyses-of-simulated-moving-bed-with-internal-temperature-gradients-for-binary-separation-of-ketoprofen-enantiomers-using-multi-objective-optimization-linear-equilibria
#13
Xiaoxiao Jiang, Lei Zhu, Bei Yu, Qi Su, Jin Xu, Weifang Yu
Gradient operation of a simulated moving bed (SMB) can improve the separation and purification performance by adjusting adsorption strength in each individual zone according to its functional role. The feasibility of an internal temperature gradient (ITG) established by a difference between feed and desorbent temperatures for binary separation of ketoprofen enantiomers was investigated based on simultaneous optimization of purity and productivity of S-ketoprofen, the preferentially adsorbed species and desired product...
November 21, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29172026/effect-of-non-prohibited-drugs-on-the-phase-ii-metabolic-profile-of-morphine-an-in-vitro-investigation-for-doping-control-purposes
#14
Gabriella Ambrosio, Xavier de la Torre, Monica Mazzarino, Maria K Parr, Francesco Botrè
The potential consequences of drug-drug interaction on the strategies adopted by the anti-doping laboratories to report an adverse analytical finding for morphine were investigated. We have evaluated in vitro the effects of fourteen drugs on the principal metabolic pathways of morphine. The selected drugs are among those most commonly used by the athletes, none of them presently included in the World Anti-Doping Agency Prohibited List. The non-prohibited drugs included four antifungals (fluconazole, itraconazole, ketoconazole and miconazole), six benzodiazepines (alprazolam, bromazepam, clonazepam, lorazepam, lormetazepam and triazolam), and four non-steroidal anti-inflammatory drugs (diclofenac, ibuprofen, ketoprofen and nimesulide)...
November 24, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/29154881/influence-of-polymer-ratio-and-surfactants-on-controlled-drug-release-from-cellulosic-microsponges
#15
Yasser Shahzad, Sidra Saeed, Muhammad Usman Ghori, Tariq Mahmood, Abid Mehmood Yousaf, Muhammad Jamshaid, Rizwan Sheikh, Syed A A Rizvi
Microsponge refers to a highly cross-linked particle system with a capacity to adsorb (like a dry sponge) pharmaceutical materials. There are various methods available to prepare microsponge formulations, in this study we used quasi emulsion-solvent diffusion method with a combination of hydrophobic (ethyl cellulose) and hydrophilic polymers (hydroxypropyl methylcellulose) mediated via Tween 80 and polyvinyl alcohol. Various ratios and amounts of the polymers and surfactants were used to prepare microsponge formulations using ketoprofen as a model drug and extensively characterised...
November 14, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29131239/effectiveness-of-a-novel-boswellic-acids-delivery-form-casperome%C3%A2-in-the-management-of-grade-ii-ankle-sprains-due-to-sport-trauma-a-registry-study
#16
B Feragalli, E Ippolito, M Dugall, M Cacchio, G Belcaro, M R Cesarone, M Abdel-Tawab, A Riva, S Togni, R Eggenhoffner, L Giacomelli
OBJECTIVE: In this study, we evaluated a novel delivery form of boswellic acids (Casperome®) in the management of signs and symptoms associated with ankle sprain grade II due to sport trauma. PATIENTS AND METHODS: In this supplement registry study, 72 otherwise healthy subjects with grade II ankle sprain induced by sport activities were advised to either follow a standard management (SM, 37 subjects) for the condition or the SM with the additional daily intake of 1 tablet containing 250 mg Casperome® (35 subjects)...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29127620/potential-of-the-strain-raoultella-sp-kdf8-for-removal-of-analgesics
#17
Andrea Palyzová, Jiří Zahradník, Helena Marešová, Lucie Sokolová, Eva Kyslíková, Michal Grulich, Václav Štěpánek, Tomáš Řezanka, Pavel Kyslík
The bacterial strain KDF8 capable of growth in the presence of diclofenac and codeine analgesics was obtained after chemical mutagenesis of nature isolates from polluted soils. The strain KDF8 was identified as Raoultella sp. based on its morphology, biochemical properties, and 16S rRNA gene sequence. It was deposited in the Czech Collection of Microorganisms under the number CCM 8678. A growing culture efficiently removed diclofenac (92% removal) and partially also codeine (about 30% degradation) from culture supernatants within 72 h at 28 °C...
November 11, 2017: Folia Microbiologica
https://www.readbyqxmd.com/read/29124963/relevance-and-bio-catalytic-strategies-for-the-kinetic-resolution-of-ketoprofen-towards-dexketoprofen
#18
María Victoria Toledo, Laura Estefanía Briand
This review presents the most relevant investigations concerning the biocatalytic kinetic resolution of racemic ketoprofen to dexketoprofen for the last 22 years. The advantages related to the administration of the dex-enantiomer in terms of human health, the so called "chiral switch" in the pharmaceutical industry and the sustainability of biotransformations have been the driving forces to develop innovative technology to obtain dexketoprofen. In particular, the kinetic resolution of racemic ketoprofen through enantiomeric esterification and hydrolysis using lipases as biocatalysts are thoroughly revised and commented upon...
November 10, 2017: Critical Reviews in Biotechnology
https://www.readbyqxmd.com/read/29104055/improving-the-direct-penetration-into-tissues-underneath-the-skin-with-iontophoresis-delivery-of-a-ketoprofen-cationic-prodrug
#19
Shabbir Lobo, Guang Yan
Current topical nonsteroidal anti-inflammatory drugs (NSAIDs) showed marginal efficacy in treatment of musculoskeletal disorders due to their fast clearance by skin blood flow and thus little direct penetration into the underlying muscle and joint tissues. Using ketoprofen (Kt) as a model NSAID and converting it to a cationic ester prodrug ketoprofen choline chloride (KCC), this study was to investigate the iontophoresis delivery of the prodrug KCC for improving the drug retention in the skin and the direct penetration into underlying tissues...
November 14, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29102060/multifunctionalized-mesoporous-silica-as-an-efficient-reversed-phase-anion-exchange-mixed-mode-sorbent-for-solid-phase-extraction-of-four-acidic-nonsteroidal-anti-inflammatory-drugs-in-environmental-water-samples
#20
Yun Li, Chaonan Huang, Jiajia Yang, Junyu Peng, Jing Jin, Huilian Ma, Jiping Chen
A mesoporous silica Santa Barbara Amorphous-15 (SBA-15) has been first functionalized with 3-[2-(2-aminoethylamino)ethylamino]propyl-trimethoxysilane (a silane with three amines) and then reacted with an excess of phenyl glycidyl ether to generate a mixed-mode anion-exchanger containing both anion-exchange (three amines) and reversed-phase (multiple ether-linked phenyls) functionalities in a single branched ligand. The resulting material has been characterized by scanning electron microscopy, transmission electron microscopy, nitrogen adsorption-desorption measurements, Fourier-transform infrared spectroscopy, and elemental analysis...
October 23, 2017: Journal of Chromatography. A
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