Marcel Henrique Marcondes Sari, Camila Parcianello Saccol, Vanessa Neuenschwander Custódio, Lucas Saldanha da Rosa, Juliê Silveira da Costa, André Ricardo Fajardo, Luana Mota Ferreira, Letícia Cruz
Ketoprofen (KET), commonly used for inflammation in clinical settings, leads to systemic adverse effects with prolonged use, mitigated by topical administration. Nanotechnology-based cutaneous forms, like films, may enhance KET efficacy. Therefore, this study aimed to prepare and characterize films containing KET nanoemulsions (F-NK) regarding mechanical properties, chemical composition and interactions, occlusive potential, bioadhesion, drug permeation in human skin, and safety. The films were prepared using a κ-carrageenan and xanthan gum blend (2 % w/w, ratio 3: 1) plasticized with glycerol through the solvent casting method...
March 15, 2024: International Journal of Biological Macromolecules