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ketoprofen

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https://www.readbyqxmd.com/read/28343346/molecularly-imprinted-polymer-prepared-with-polyhedral-oligomeric-silsesquioxane-through-reversible-addition-fragmentation-chain-transfer-polymerization
#1
Shu-Ping Gao, Xue Zhang, Li-Shun Zhang, Yan-Ping Huang, Zhao-Sheng Liu
Polyhedral oligomeric silsesquioxane (POSS) was utilized to prepare imprinted polymer through reversible addition-fragmentation chain transfer polymerization (RAFT) successfully. The imprinted polymer was made with a mixture of RAFT agent, 4-vinylpyridine (4-VP), POSS monomer [PSS-(1-propylmethacrylate)-heptaisobutyl substituted, MA 0702], and ethylene glycol dimethacrylate (EDMA), with ketoprofen (KET) as template. The influence of polymerization variables, the amount of RAFT agent and POSS monomer, the ratio of KET to 4-VP, and the ratio of 4-VP to EDMA, were investigated on the retention factor and imprinting effect...
March 25, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28337899/substance-p-expression-in-the-gingival-tissue-after-upper-third-molar-extraction-effect-of-ketoprofen-a-preliminary-study
#2
G M Abbate, A Mangano, P Sacerdote, G Amodeo, G Moschetti, L Levrini
The aim of this study was to evaluate substance P (SP) levels and the effect of a non-steroidal anti-inflammatory drug (NSAID), ketoprofen, on SP in the pericoronal gingival tissue after extraction of upper third molars. A sample of 20 young non-smoking systemically healthy adults of both sexes, with a healthy upper third molar to extract for orthodontic purposes, was selected. After extraction, a sample of the gingival tissue of the pericoronal region was collected with a sterile scalpel, placed into test tubes and kept frozen at -20°C until the SP determination...
January 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28285173/peptide-dendrimer-conjugates-of-ketoprofen-synthesis-and-ex-vivo-and-in-vivo-evaluations-of-passive-diffusion-sonophoresis-and-iontophoresis-for-skin-delivery
#3
Aswathi R Hegde, Prarthana V Rewatkar, Jyothsna Manikkath, Karnaker Tupally, Harendra S Parekh, Srinivas Mutalik
The aim of this study was to evaluate skin delivery of ketoprofen when covalently tethered to mildly cationic (2(+) or 4(+)) peptide dendrimers prepared wholly by solid phase peptide synthesis. The amino acids glycine, arginine and lysine formed the dendrimer with ketoprofen tethered either to the lysine side-arm (Nε) or periphery of dendrimeric branches. Passive diffusion, sonophoresis- and iontophoresis-assisted permeation of each peptide dendrimer-drug conjugate (D1-D4) was studied across mouse skin, both in vitro and in vivo...
March 8, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28266283/biochemical-histopathologic-physiologic-and-behavioral-effects-of-nonsteroidal-antiinflammatory-drugs-in-rainbow-trout-oncorhynchus-mykiss
#4
Amy L Rizzo Gregory A Wooster Luce E Guanzini Christine M Peterson Karryssa S Fenderson Hollis N Erb Paul R Bowser And Mary E Martin
Because the number of fish being used in research is increasing rapidly, evaluating the analgesic and pathologic effects of NSAIDin fish is essential. To determine the biochemical, histopathologic, physiologic and behavioral effects of 3 NSAID, 48 rainbow trout underwent anesthesia with tricaine methanesulfonate and exploratory celiotomy and were randomly assigned to receive flunixin(0.5 mg/kg IM), ketorolac (0.5 mg/kg IM), ketoprofen (2 mg/kg IM), or saline. Clinical pathologic variables were assessed 1 wk before surgery and 48 h after surgery...
March 6, 2017: Comparative Medicine
https://www.readbyqxmd.com/read/28262313/high-performance-liquid-chromatography-mass-spectrometry-analysis-of-the-parent-drugs-and-their-metabolites-in-extracts-from-cress-lepidium-sativum-grown-hydroponically-in-water-containing-four-non-steroidal-anti-inflammatory-drugs
#5
Lisa Emhofer, Markus Himmelsbach, Wolfgang Buchberger, Christian W Klampfl
In this paper the metabolism of four non-steroidal anti-inflammatory drugs, (ketoprofen, mefenamic acid, naproxen, and diclofenac) by cress (Lepidium sativum) is described. Cress was cultivated hydroponically in water spiked with the parent drugs at levels ranging from 0.01mgL(-1) to 1mgL(-1). Employing an approach based on the analysis of the plant extracts by HPLC coupled either with quadrupole-time-of-flight mass spectrometry, or Orbitrap MS or triple quadrupole (QqQ) MS allowed the identification of twenty substances (sixteen metabolites and four parent drugs)...
March 31, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28259627/synthesis-of-novel-trifluoromethyl-substituted-spiro-chromeno-4-3-d-pyrimidine-5-1-cycloalkanes-and-evaluation-of-their-analgesic-effects-in-a-mouse-pain-model
#6
Helio G Bonacorso, Wilian C Rosa, Sara M Oliveira, Indiara Brusco, Evelyne S Brum, Melissa B Rodrigues, Clarissa P Frizzo, Nilo Zanatta
Herein we report the synthesis of twelve 2,5-substituted 4-(trifluoromethyl)-spirochromeno[4,3-d]pyrimidines (7-10), as well as an evaluation of their analgesic effect in a mouse pain model. The nine new chromeno[4,3-d]pyrimidines (7-9) were synthesized from the cyclocondensation reactions of three 2,2,2-trifluoro-1-(4-methoxyspiro[chromene-2,1'-cycloalkane]-3-yl)ethanones (3) containing 5-, 6- and 7-membered spirocycloalkanes, with some well-known amidine salts (4-6) [NH2CR(NH)]-in which R=Me, Ph, and NH2-at yields of 60-95%...
April 1, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28258852/epidemiology-of-anaphylaxis-a-retrospective-cohort-study-in-taiwan
#7
Yow-Shan Lee, Wei-Zen Sun
OBJECTIVE: Medication-induced anaphylaxis is a potentially fatal event. Little is known at present about the patterns of medication-induced anaphylaxis in Asian countries. The current study aims to examine the pattern of documented incidences of drug-associated anaphylaxis in Taiwan over a 9-year period. METHODS: Cases of medication-associated anaphylaxis documented in the Taiwan National Health Insurance claims database during a span of 9 years (from January, 1997 to December, 2005) encompassing approximately 23 million person-years were reviewed...
February 28, 2017: Acta Anaesthesiologica Taiwanica: Official Journal of the Taiwan Society of Anesthesiologists
https://www.readbyqxmd.com/read/28254731/remediation-of-a-mixture-of-analgesics-in-a-stirred-tank-photobioreactor-using-microalgal-bacterial-consortium-coupled-with-attempt-to-valorise-the-harvested-biomass
#8
Maha M Ismail, Tamer M Essam, Yasser M Ragab, Abo El-Khair B El-Sayed, Fathia E Mourad
An artificial microalgal-bacterial consortium was used to remediate a mixture of analgesics (ketoprofen, paracetamol and aspirin) in a stirred-tank photobioreactor. A hydraulic retention time (HRT) of 3days supported poor treatment because of the formation of p-aminophenol (paracetamol toxic metabolite). Increasing the HRT to 4days enhanced the bioremediation efficiency. After applying an acclimatization regime, 95% removal of the analgesics mixture, p-aminophenol and COD reduction were achieved. However, shortening the HRT again to 3days neither improved the COD reduction nor ketoprofen removal...
February 20, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28235622/an-equation-for-the-prediction-of-human-skin-permeability-of-neutral-molecules-ions-and-ionic-species
#9
Keda Zhang, Michael H Abraham, Xiangli Liu
Experimental values of permeability coefficients, as log Kp, of chemical compounds across human skin were collected by carefully screening the literature, and adjusted to 37°C for the effect of temperature. The values of log Kp for partially ionized acids and bases were separated into those for their neutral and ionic species, forming a total data set of 247 compounds and species (including 35 ionic species). The obtained log Kp values have been regressed against Abraham solute descriptors to yield a correlation equation with R(2)=0...
February 22, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28215167/chemical-modifications-of-ketoprofen-nsaid-in-search-of-better-lead-compounds-a-review-of-literature-from-2004-2016
#10
Gita Chawla, Chanda Ranjan, Anees A Siddiqui, Jagdish Kumar, Ankita Pathak
BACKGROUND: Ketoprofen, a potent anti-inflammatory, analgesic and anti-pyretic drug belonging to the propionic acid class was synthesized in 1968. Rapid absorption, simple metabolism, faster blood brain barrier crossing and high antinociceptive activity are the features responsible for its high use. But, free acidic moiety present in its structure is the major factor that declines its popularity by causing various gastric side effects .Many researchers have chemically modified this drug with the aim to discover an improved and safe NSAID candidate or a new drug with altered activity...
February 16, 2017: Anti-inflammatory & Anti-allergy Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28199939/sorption-and-desorption-of-selected-non-steroidal-anti-inflammatory-drugs-in-an-agricultural-loam-textured-soil
#11
Y Zhang, G W Price, R Jamieson, D Burton, K Khosravi
Non-steroidal, anti-inflammatory drugs (NSAIDs) are widely used pharmaceutical products with analgesic and anti-inflammatory effects that are consistently detected in municipal wastewater systems and in municipal biosolids. Land application of biosolids and irrigation with reclaimed wastewater introduces these compounds into agricultural environments, which is an emerging issue of concern for ecosystem health. In this study, the sorption-desorption behaviour of four commonly consumed NSAIDs, including naproxen (NPX), ibuprofen (IBU), ketoprofen (KTF), and diclofenac (DCF), was examined in a loam textured soil exposed to either an individual-compound or a mixture of the four NSAIDs...
May 2017: Chemosphere
https://www.readbyqxmd.com/read/28185988/effects-of-nonsteroidal-anti-inflammatory-drugs-on-the-renal-excretion-of-indoxyl-sulfate-a-nephro-cardiovascular-toxin-in-rats
#12
Chung-Ping Yu, Douglas H Sweet, Yu-Hsuan Peng, Yow-Wen Hsieh, Pei-Dawn Lee Chao, Yu-Chi Hou, Shiuan-Pey Lin
Chronic kidney disease (CKD) is a health problem worldwide. Indoxyl sulfate (IS) is a nephro-cardiovascular toxin accumulated in CKD patients and cannot be removed through hemodialysis. The renal excretion of IS was mediated by organic anion transporters (OATs) OAT 1 and OAT 3. Because a number of nonsteroidal anti-inflammatory drugs (NSAIDs) have been reported to inhibit OATs, we hypothesize that NSAIDs might inhibit the renal excretion of IS. Rats were intravenously injected IS with and without diclofenac, ketoprofen or salicylic acid, individually...
April 1, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28178590/the-pharmacokinetics-of-oral-ketoprofen-in-patients-after-gastric-resection
#13
Joanna Porażka, Agnieszka Karbownik, Dawid Murawa, Arkadiusz Spychała, Magdalena Firlej, Tomasz Grabowski, Paweł Murawa, Edmund Grześkowiak, Edyta Szałek
BACKGROUND: Total and partial gastric resection may affect the pharmacokinetics of drugs, especially orally administered a few days after surgery. Ketoprofen is a non-steroidal anti-inflammatory drug (NSAID) broadly used to treat postoperative pain, including patients after gastric resection. The aim of the research was to analyse the pharmacokinetics (PK) of orally administered ketoprofen in patients after gastrectomy. METHODS: The research was carried out on two groups of patients after total (TG; Roux-Y procedure) and partial (PG; Billroth II procedure) gastrectomy...
April 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28163223/influence-of-peptide-dendrimers-and-sonophoresis-on-the-transdermal-delivery-of-ketoprofen
#14
Jyothsna Manikkath, Aswathi R Hegde, Guruprasad Kalthur, Harendra S Parekh, Srinivas Mutalik
The aim of this study was to determine the individual and combined effects of peptide dendrimers and low frequency ultrasound on the transdermal permeation of ketoprofen. Arginine terminated peptide dendrimers of varying charges (4(+), 8(+) and 16(+), named as A4. A8 and A16 respectively) were synthesized and characterized. Ketoprofen was subjected to passive, peptide dendrimer-assisted and sonophoretic permeation studies (with and without dendrimer application) across Swiss albino mouse skin, both in vitro and in vivo...
February 2, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28162239/evaluation-of-drug-loading-capabilities-of-%C3%AE-cyclodextrin-metal-organic-frameworks-by-high-performance-liquid-chromatography
#15
Xiaonan Xu, Caifen Wang, Haiyan Li, Xue Li, Botao Liu, Vikramjeet Singh, Shuxia Wang, Lixin Sun, Ruxandra Gref, Jiwen Zhang
Drug loading into γ-cyclodextrin-metal organic frameworks (γ-CD-MOFs) using the impregnation approach is a laborious process. In this study, a γ-CD-MOF construct (2-5μm particle diameter) was used as the stationary phase under HPLC conditions with the aim to correlate retention properties and drug loading capability of the CD-based structure. Ketoprofen, fenbufen and diazepam were chosen as model drugs with m-xylene as a control analyte to investigate the correlation of drug loading and their chromatographic behaviour in the γ-CD-MOF column...
March 10, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28159639/mucoadhesive-properties-of-thiolated-pectin-based-pellets-prepared-by-extrusion-spheronization-technique
#16
André Luiz Lopes Martins, Aline Carlos de Oliveira, Carolina Machado Ozório Lopes do Nascimento, Luís Antônio Dantas Silva, Marilisa Pedroso Nogueira Gaeti, Eliana Martins Lima, Stephânia Fleury Taveira, Kátia Flávia Fernandes, Ricardo Neves Marreto
The aim of this study was to develop mucoadhesive pellets on a thiolated pectin base using the extrusion-spheronization technique. Thiolation of pectin was performed by esterification with thioglycolic acid. The molecular weight and thiol group content of the pectins were determined. Pellets containing pectin, microcrystalline cellulose and ketoprofen were prepared and their mucoadhesive properties were evaluated through a wash-off test using porcine intestinal mucosa. The in vitro ketoprofen release was also evaluated...
January 31, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28131496/core-sheath-nanofibers-as-drug-delivery-system-for-thermoresponsive-controlled-release
#17
Yao Lv, Qixia Pan, S W Annie Bligh, Heyu Li, Huanling Wu, Qingqing Sang, Li-Min Zhu
In this work, a smart drug delivery system of core-sheath nanofiber is reported. The core-sheath nanofibers were prepared with thermoresponsive poly-(N-isopropylacrylamide) (as core) and hydrophobic ethyl cellulose (as sheath) by coaxial electrospinning. Analogous medicated fibers were prepared by loading with a model drug ketoprofen (KET). The fibers were cylindrical without phase separation and have visible core-sheath structure as shown by scanning and transmission electron microscopy. X-ray diffraction patterns demonstrated the drug with the amorphous physical form was present in the fiber matrix...
January 26, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28113125/mechanism-of-drug-release-from-silica-gelatin-aerogel-relationship-between-matrix-structure-and-release-kinetics
#18
Péter Veres, Mónika Kéri, István Bányai, István Lázár, István Fábián, Concepción Domingo, József Kalmár
Specific features of a silica-gelatin aerogel (3 wt.% gelatin content) in relation to drug delivery has been studied. It was confirmed that the release of both ibuprofen (IBU) and ketoprofen (KET) is about tenfold faster from loaded silica-gelatin aerogel than from pure silica aerogel, although the two matrices are structurally very similar. The main goal of the study was to understand the mechanistic background of the striking difference between the delivery properties of these closely related porous materials...
April 1, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28091717/bar-adsorptive-microextraction-technique-application-for-the-determination-of-pharmaceuticals-in-real-matrices
#19
Carlos Almeida, Samir M Ahmad, José Manuel F Nogueira
In the present work, bar adsorptive microextraction using miniaturized devices (7.5 × 3.0 mm) coated with suitable sorbent phases, combined with microliquid desorption (100 μL) followed by high-performance liquid chromatography with diode array detection (BAμE-μLD/HPLC-DAD), is proposed for the determination of trace level of six pharmaceuticals (furosemide, mebeverine, ketoprofen, naproxen, diclofenac and mefenamic acid) in environmental water and urine matrices. By comparing ten distinct sorbent materials (five polymeric and five activated carbons), the polymer P5 proved to be the most suitable to achieve the best selectivity and efficiency...
January 16, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28077538/magnesium-sulphate-attenuates-acute-postoperative-pain-and-increased-pain-intensity-after-surgical-injury-in-staged-bilateral-total-knee-arthroplasty-a-randomized-double-blinded-placebo-controlled-trial
#20
H-J Shin, E-Y Kim, H-S Na, T K Kim, M-H Kim, S-H Do
BACKGROUND: We evaluated the effect of magnesium sulphate on increased pain in 44 patients undergoing staged bilateral total knee arthroplasty (TKA). METHODS: The magnesium group (n=22) and the control group (n=22) received magnesium sulphate and isotonic saline, respectively, throughout the surgery. Postoperative pain (visual analogue scale, VAS) at rest and the amounts of patient-controlled analgesia (PCA, fentanyl) and rescue analgesia (ketoprofen) administered during the first 48 h were compared between the two groups and within each group between the first and second TKA...
October 2016: British Journal of Anaesthesia
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