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https://www.readbyqxmd.com/read/28199939/sorption-and-desorption-of-selected-non-steroidal-anti-inflammatory-drugs-in-an-agricultural-loam-textured-soil
#1
Y Zhang, G W Price, R Jamieson, D Burton, K Khosravi
Non-steroidal, anti-inflammatory drugs (NSAIDs) are widely used pharmaceutical products with analgesic and anti-inflammatory effects that are consistently detected in municipal wastewater systems and in municipal biosolids. Land application of biosolids and irrigation with reclaimed wastewater introduces these compounds into agricultural environments, which is an emerging issue of concern for ecosystem health. In this study, the sorption-desorption behaviour of four commonly consumed NSAIDs, including naproxen (NPX), ibuprofen (IBU), ketoprofen (KTF), and diclofenac (DCF), was examined in a loam textured soil exposed to either an individual-compound or a mixture of the four NSAIDs...
February 6, 2017: Chemosphere
https://www.readbyqxmd.com/read/28185988/effects-of-nonsteroidal-anti-inflammatory-drugs-on-the-renal-excretion-of-indoxyl-sulfate-a-nephro-cardiovascular-toxin-in-rats
#2
Chung-Ping Yu, Douglas H Sweet, Yu-Hsuan Peng, Yow-Wen Hsieh, Pei-Dawn Lee Chao, Yu-Chi Hou, Shiuan-Pey Lin
Chronic kidney disease (CKD) is a health problem worldwide. Indoxyl sulfate (IS) is a nephro-cardiovascular toxin accumulated in CKD patients and cannot be removed through hemodialysis. The renal excretion of IS was mediated by organic anion transporters (OATs) OAT 1 and OAT 3. Because a number of nonsteroidal anti-inflammatory drugs (NSAIDs) have been reported to inhibit OATs, we hypothesize that NSAIDs might inhibit the renal excretion of IS. Rats were intravenously injected IS with and without diclofenac, ketoprofen or salicylic acid, individually...
February 7, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28178590/the-pharmacokinetics-of-oral-ketoprofen-in-patients-after-gastric-resection
#3
Joanna Porażka, Agnieszka Karbownik, Dawid Murawa, Arkadiusz Spychała, Magdalena Firlej, Tomasz Grabowski, Paweł Murawa, Edmund Grześkowiak, Edyta Szałek
BACKGROUND: Total and partial gastric resection may affect the pharmacokinetics of drugs, especially orally administered a few days after surgery. Ketoprofen is a non-steroidal anti-inflammatory drug (NSAID) broadly used to treat postoperative pain, including patients after gastric resection. The aim of the research was to analyse the pharmacokinetics (PK) of orally administered ketoprofen in patients after gastrectomy. METHODS: The research was carried out on two groups of patients after total (TG; Roux-Y procedure) and partial (PG; Billroth II procedure) gastrectomy...
December 9, 2016: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28163223/influence-of-peptide-dendrimers-and-sonophoresis-on-the-transdermal-delivery-of-ketoprofen
#4
Jyothsna Manikkath, Aswathi R Hegde, Guruprasad Kalthur, Harendra S Parekh, Srinivas Mutalik
The aim of this study was to determine the individual and combined effects of peptide dendrimers and low frequency ultrasound on the transdermal permeation of ketoprofen. Arginine terminated peptide dendrimers of varying charges (4(+), 8(+) and 16(+), named as A4. A8 and A16 respectively) were synthesized and characterized. Ketoprofen was subjected to passive, peptide dendrimer-assisted and sonophoretic permeation studies (with and without dendrimer application) across Swiss albino mouse skin, both in vitro and in vivo...
February 2, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28162239/evaluation-of-drug-loading-capabilities-of-%C3%AE-cyclodextrin-metal-organic-frameworks-by-high-performance-liquid-chromatography
#5
Xiaonan Xu, Caifen Wang, Haiyan Li, Xue Li, Botao Liu, Vikramjeet Singh, Shuxia Wang, Lixin Sun, Ruxandra Gref, Jiwen Zhang
Drug loading into γ-cyclodextrin-metal organic frameworks (γ-CD-MOFs) using the impregnation approach is a laborious process. In this study, a γ-CD-MOF construct (2-5μm particle diameter) was used as the stationary phase under HPLC conditions with the aim to correlate retention properties and drug loading capability of the CD-based structure. Ketoprofen, fenbufen and diazepam were chosen as model drugs with m-xylene as a control analyte to investigate the correlation of drug loading and their chromatographic behaviour in the γ-CD-MOF column...
March 10, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28159639/mucoadhesive-properties-of-thiolated-pectin-based-pellets-prepared-by-extrusion-spheronization-technique
#6
André Luiz Lopes Martins, Aline Carlos de Oliveira, Carolina Machado Ozório Lopes do Nascimento, Luís Antônio Dantas Silva, Marilisa Pedroso Nogueira Gaeti, Eliana Martins Lima, Stephânia Fleury Taveira, Kátia Flávia Fernandes, Ricardo Neves Marreto
The aim of this study was to develop mucoadhesive pellets on a thiolated pectin base using the extrusion-spheronization technique. Thiolation of pectin was performed by esterification with thioglycolic acid. The molecular weight and thiol group content of the pectins were determined. Pellets containing pectin, microcrystalline cellulose and ketoprofen were prepared and their mucoadhesive properties were evaluated through a wash-off test using porcine intestinal mucosa. The in vitro ketoprofen release was also evaluated...
January 31, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28131496/core-sheath-nanofibers-as-drug-delivery-system-for-thermoresponsive-controlled-release
#7
Yao Lv, Qixia Pan, S W Annie Bligh, Heyu Li, Huanling Wu, Qingqing Sang, Li-Min Zhu
In this work, a smart drug delivery system of core-sheath nanofiber is reported. The core-sheath nanofibers were prepared with thermoresponsive poly-(N-isopropylacrylamide) (PNIPAAm) (as core) and hydrophobic ethylcellulose (EC) (as sheath) by coaxial electrospinning. Analogous medicated fibers were prepared by loading with a model drug ketoprofen (KET). The fibers were cylindrical without phase separation and have visible core-sheath structure as shown by scanning and transmission electron microscopy. X-ray diffraction patterns demonstrated the drug with the amorphous physical form was present in the fiber matrix...
January 25, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28113125/mechanism-of-drug-release-from-silica-gelatin-aerogel-relationship-between-matrix-structure-and-release-kinetics
#8
Péter Veres, Mónika Kéri, István Bányai, István Lázár, István Fábián, Concepción Domingo, József Kalmár
Specific features of a silica-gelatin aerogel (3 wt.% gelatin content) in relation to drug delivery has been studied. It was confirmed that the release of both ibuprofen (IBU) and ketoprofen (KET) is about tenfold faster from loaded silica-gelatin aerogel than from pure silica aerogel, although the two matrices are structurally very similar. The main goal of the study was to understand the mechanistic background of the striking difference between the delivery properties of these closely related porous materials...
January 17, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28091717/bar-adsorptive-microextraction-technique-application-for-the-determination-of-pharmaceuticals-in-real-matrices
#9
Carlos Almeida, Samir M Ahmad, José Manuel F Nogueira
In the present work, bar adsorptive microextraction using miniaturized devices (7.5 × 3.0 mm) coated with suitable sorbent phases, combined with microliquid desorption (100 μL) followed by high-performance liquid chromatography with diode array detection (BAμE-μLD/HPLC-DAD), is proposed for the determination of trace level of six pharmaceuticals (furosemide, mebeverine, ketoprofen, naproxen, diclofenac and mefenamic acid) in environmental water and urine matrices. By comparing ten distinct sorbent materials (five polymeric and five activated carbons), the polymer P5 proved to be the most suitable to achieve the best selectivity and efficiency...
January 16, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28077538/magnesium-sulphate-attenuates-acute-postoperative-pain-and-increased-pain-intensity-after-surgical-injury-in-staged-bilateral-total-knee-arthroplasty-a-randomized-double-blinded-placebo-controlled-trial
#10
H-J Shin, E-Y Kim, H-S Na, T K Kim, M-H Kim, S-H Do
BACKGROUND: We evaluated the effect of magnesium sulphate on increased pain in 44 patients undergoing staged bilateral total knee arthroplasty (TKA). METHODS: The magnesium group (n=22) and the control group (n=22) received magnesium sulphate and isotonic saline, respectively, throughout the surgery. Postoperative pain (visual analogue scale, VAS) at rest and the amounts of patient-controlled analgesia (PCA, fentanyl) and rescue analgesia (ketoprofen) administered during the first 48 h were compared between the two groups and within each group between the first and second TKA...
October 2016: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28074422/compacted-multiparticulate-systems-for-colon-specific-delivery-of-ketoprofen
#11
Rodrigo Gomes de Alencar, Aline Carlos de Oliveira, Eliana Martins Lima, Marcílio Sérgio Soares da Cunha-Filho, Stephânia Fleury Taveira, Ricardo Neves Marreto
Pellet-containing tablets for colon-specific drug delivery present higher targeting efficiency and lower costs when compared with monolithic tablets and pellet-filled capsules, respectively. In this study, pellets containing ketoprofen were coated with different acrylic polymers and submitted to compaction. The influence of formulation and process factors on film integrity was then evaluated. Pellets were prepared via extrusion-spheronization and coated using two acrylic polymers (Eudragit® FS 30 D and Opadry® 94 k28327, PMMA and PMA, respectively)...
January 10, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28063293/adsorption-of-non-steroidal-anti-inflammatory-drugs-from-aqueous-solution-using-activated-carbons-review
#12
REVIEW
Muthanna J Ahmed
Pharmaceutical pollutants are of significant effect on the environment, so that their treatments have been addressed in many studies. Activated carbon (AC) adsorbent shows best attraction for these compounds due to its unique characteristics represented by high capacity and porosity. In this article, the adsorption performance of AC towards non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, ketoprofen, naproxen, and diclofenac were reviewed. According to collected data, maximum adsorption capacities of 417, 25, 290, and 372 mg/g were obtained from Langmuir isotherm for these drugs, respectively...
April 1, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28061011/simultaneous-enantiomeric-analysis-of-pharmacologically-active-compounds-in-environmental-samples-by-chiral-lc-ms-ms-with-a-macrocyclic-antibiotic-stationary-phase
#13
D Camacho-Muñoz, B Kasprzyk-Hordern
This paper presents a multi-residue method for direct enantioselective separation of chiral pharmacologically active compounds in environmental matrices. The method is based on chiral liquid chromatography and tandem mass spectrometry detection. Simultaneous chiral discrimination was achieved with a macrocyclic glycopeptide-based column with antibiotic teicoplanin as a chiral selector working under reverse phase mode. For the first time, enantioresolution was reported for metabolites of ibuprofen: carboxyibuprofen and 2-hydroxyibuprofen with this chiral stationary phase...
January 6, 2017: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/28052193/distribution-of-animal-drugs-among-curd-whey-and-milk-protein-fractions-in-spiked-skim-milk-and-whey
#14
Nancy W Shappell, Weilin L Shelver, Sara J Lupton, Wendy Fanaselle, Jane M Van Doren, Heldur Hakk
It is important to understand the partitioning of drugs in processed milk and milk products, when drugs are present in raw milk, in order to estimate the potential consumer exposure. Radioisotopically labeled erythromycin, ivermectin, ketoprofen, oxytetracycline, penicillin G, sulfadimethoxine, and thiabendazole were used to evaluate the distribution of animal drugs among rennet curd, whey, and protein fractions from skim cow milk. Our previous work reported the distribution of these same drugs between skim and fat fractions of milk...
February 1, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28051129/high-quality-metal-organic-framework-zif-8-membrane-supported-on-electrodeposited-zno-2-methylimidazole-nanocomposite-efficient-adsorbent-for-the-enrichment-of-acidic-drugs
#15
Mian Wu, Huili Ye, Faqiong Zhao, Baizhao Zeng
Metal-organic framework (MOF) membranes have received increasing attention as adsorbents, yet the defects in most membrane structures greatly thwart their capacity performance. In this work, we fabricated a novel ZnO/2-methylimidazole nanocomposite with multiple morphology by electrochemical method. The nanocomposite provided sufficient and strong anchorages for the zeolitic imidazolate frameworks-8 (ZIF-8) membrane. Thus, a crack-free and uniform MOF membrane with high performance was successfully obtained...
January 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28050748/development-of-diagnostic-techniques-for-early-rheumatoid-arthritis-using-positron-emission-tomography-with-11-c-pk11195-and-11-c-ketoprofen-tracers
#16
Satoshi Nozaki, Naoko Ozaki, Shinobu Suzuki, Miki Goto, Aya Mawatari, Yuka Nakatani, Emi Hayashinaka, Yasuhiro Wada, Hisashi Doi, Yasuyoshi Watanabe
PURPOSE: In vivo detection of pathological insults during the early stages of rheumatoid synovitis is essential to allow early anti-inflammatory treatment for prevention of joint destruction. Whether rheumatoid synovitis pathology and the efficacy of therapies can be visualized by positron emission tomography (PET) tracers specific to the inflammatory process was investigated. PROCEDURES: Using a collagen-induced experimental rat model of rheumatoid arthritis, in vivo imaging using the PET tracers [(11)C]PK11195, which binds to the translocator protein mainly expressed on myeloid cells, and [(11)C]ketoprofen, for cyclooxygenase imaging, was performed...
January 3, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28046151/pain-alleviation-during-castration-of-piglets-a-comparative-study-of-different-farm-options
#17
F Gottardo, A Scollo, B Contiero, A Ravagnani, G Tavella, D Bernardini, G M De Benedictis, S A Edwards
Pain alleviation associated with castration of piglets is an important welfare issue. The present study compares the effect of different approaches and products suitable for farmer use, with the aim to alleviate pain due to castration in piglets. A randomized within-litter design, with 28 replicate litters, compared 7 treatments: handling () restraint of the piglet and manipulation of the scrotum, castration without pain relief (), 2 treatments (, ) with different concentrations of tetracaine (2 and 6%) applied topically 10 min before and immediately post-surgery, and 3 treatments with i...
December 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/28045261/intracellular-enzymes-contribution-to-the-biocatalytic-removal-of-pharmaceuticals-by-trametes-hirsuta
#18
Lounès Haroune, Sabrina Saibi, Hubert Cabana, Jean-Philippe Bellenger
The use of white rot fungi (WRF) for bioremediation of recalcitrant trace organic contaminants (TrOCs) is becoming greatly popular. Biosorption and lignin modifying enzymes (LMEs) are the most often reported mechanisms of action. Intracellular enzymes, such as cytochrome P450 (CYP450), have also been suggested to contribute. However, direct evidence of TrOCs uptake and intracellular transformation is lacking. The aim of this study was to evaluate the relative contribution of biosorption, extracellular LMEs activity, TrOCs uptake, and intracellular CYP450 on the removal of six nonsteroidal anti-inflammatories (NSAIs) by Trametes hirsuta...
January 3, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28040493/characterization-of-a-novel-sgnh-type-esterase-from-lactobacillus-plantarum
#19
Yonggyu Kim, Bum Han Ryu, Jimin Kim, Wanki Yoo, Deu Rae An, Boo-Young Kim, Sena Kwon, Sojeong Lee, Ying Wang, Kyeong Kyu Kim, T Doohun Kim
Lactic acid bacteria (LAB) are sources of a large variety of microbial ester hydrolases because they can produce a wide range of short-chain esters, phenolic alcohols, and fatty acids. Here, a novel SGNH-type esterase (LpSGNH1) from Lactobacillus plantarum WCFS1 was identified, functionally characterized, and immobilized for biotechnological applications. Homologs of LpSGNH1 are also found in many lactic acid bacteria (LAB) species. Biochemical features of LpSGNH1 were investigated using mass spectrometry, gel filtration chromatography, enzyme kinetics, fluorescence, and circular dichroism (CD) spectroscopy...
December 28, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28035612/transdermal-adhesive-patches-loaded-with-ketoprofen-evaluated-by-dynamic-detection-of-percutaneous-absorption
#20
Menglin Wang, Longwei Li, Junxia Xie, Yinghua Sun, Guixia Ling, Zhonggui He
Topical delivery has many benefits toward NSAIDs administration, and the best-selling transdermal preparation in 2015 was the NSAID patch MOHRUS®. Herein, we report a ketoprofen adhesive patch (KAP) and evaluate the penetration and absorption compared to MOHRUS®. Microdialysis sampling technique was applied to determine drug penetration in the dermis and subcutaneous tissue. Simultaneously, blood samples were withdrawn over time to obtain the drug absorption in plasma. The ketoprofen concentrations in the dermis, subcutaneous tissue, and plasma were compared with the commercially available patch (MOHRUS®)...
December 29, 2016: AAPS PharmSciTech
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