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https://www.readbyqxmd.com/read/29286136/proteomic-investigation-of-the-effects-of-preimplantation-factor-on-human-embryo-implantation
#1
Min Yang, Yixuan Yang, Sha She, Sanglin Li
Despite the use of adjuvant therapies, the cumulative proportion of live births remains at ~40%. Accumulating data show that low pregnancy rates, even in the presence of high fertility rates, are due to implantation failure. The present study aimed to identify and construct a profile of proteins that react with preimplantation factor (PIF) and to provide an understanding into the molecular mechanisms by which PIF promotes trophoblast invasion. Cytoplasmic proteins were immunoprecipitated with biotin‑labeled synthetic PIF or intralipid and scrambled PIF (PIFscr)...
December 22, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29274180/association-of-intralipid-intake-in-extremely-low-birth-weight-infants-with-neurodevelopmental-outcomes
#2
William Oh, Lynn Przystac, Leslie McKinley, Richard Tucker, Elisabeth C McGowan, Betty R Vohr
AIM: To determine if high intake of Intralipid, (IL) in extremely low birthweight (ELBW) neonates is associated with higher rates of neuroimpairment and Bayley III scores at 2 years corrected age. METHODS: Quartiles of IL received by 389 ELBW infants were linked to neurodevelopmental outcomes. Logistic regression analyses, adjusted for confounders, were done to determine the association between IL dose and neuroimpairment. Linear regression analyses were done to predict Bayley III scores...
December 23, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/29274143/development-and-evaluation-of-a-connective-tissue-phantom-model-for-subsurface-visualization-of-cancers-requiring-wide-local-excision
#3
Kimberley S Samkoe, Brent D Bates, Niki N Tselepidakis, Alisha V DSouza, Jason R Gunn, Dipak B Ramkumar, Keith D Paulsen, Brian W Pogue, Eric R Henderson
Wide local excision (WLE) of tumors with negative margins remains a challenge because surgeons cannot directly visualize the mass. Fluorescence-guided surgery (FGS) may improve surgical accuracy; however, conventional methods with direct surface tumor visualization are not immediately applicable, and properties of tissues surrounding the cancer must be considered. We developed a phantom model for sarcoma resection with the near-infrared fluorophore IRDye 800CW and used it to iteratively define the properties of connective tissues that typically surround sarcoma tumors...
December 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29251551/cherenkov-excited-multi-fluorophore-sensing-in-tissue-simulating-phantoms-and-in-vivo
#4
Alisha Dsouza, Huiyun Lin, Jason R Gunn, David J Gladstone, Lesley A Jarvis, Brian W Pogue
In this work, Cherenkov-excited molecular sensing was used to assess the potential for simultaneous quantitative sensing of two NIR fluorophores within tissue-simulating phantoms through spectral separation of signals. Cherenkov emissions induced by external beam gamma photon radiation treatment to tissues/tissue-simulating phantoms were detectable over the 500-900-nm wavelength range. The presence of blood was demonstrated to reduce the integrated intensity of detected Cherenkov emissions by nearly 50%, predominantly at wavelengths below 620 nm...
December 18, 2017: Radiation Research
https://www.readbyqxmd.com/read/29239964/superior-efficacy-of-lipid-emulsion-infusion-over-serum-alkalinization-in-reversing-amitriptyline-induced-cardiotoxicity-in-guinea-pig
#5
Shogo Tsujikawa, Tadashi Matsuura, Kotaro Hori, Takashi Mori, Miyuki Kuno, Kiyonobu Nishikawa
BACKGROUND: Tricyclic antidepressants (TCAs) are a major cause of fatal drug poisoning due to their cardiotoxicity. Alkalinization by sodium bicarbonate (NaHCO3) administration, the first-line therapy for TCA-induced cardiotoxicity, can occasionally yield insufficient efficacy in severe cases. Because most TCAs are highly lipophilic, lipid emulsion may be more effective than alkalinization. However, it remains to be determined whether lipid emulsion is more beneficial than alkalinization in reversing amitriptyline-induced cardiotoxicity...
December 11, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29221728/emulsified-isoflurane-induces-release-of-cytochrome-c-in-human-neuroblastoma-shsy-5y-cells-via-jnk-c-jun-n-terminal-kinases-signaling-pathway
#6
Zeyong Yang, Jingjing Lv, Xianfu Lu, Xingxing Li, Xiaohu An, Jianwei Wang, Hao Weng, Yuanhai Li
A large number of studies have demonstrated that inhalation anesthetic isoflurane induced neural cell death by apoptosis in various cell and animal models. Emulsified isoflurane (EIso) is a new type of intravenous preparation of isoflurane that attracts increasing research attention as a promising clinical agent due to its both advantages as an intravenous and inhalation anesthetics medication. However, its safety and underlying molecular mechanism of neurotoxicity largely remain unknown. Therefore, it is meaningful to investigate the safety of EIso and to further elucidate its mechanism of anesthetic neurotoxicity...
December 5, 2017: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/29201667/the-effects-of-adjuvant-therapies-on-embryo-transfer-success
#7
Rachael Shirlow, Martin Healey, Michelle Volovsky, Vivien MacLachlan, Beverley Vollenhoven
Background: Many adjuvant therapies are employed during IVF treatment in an attempt to improve outcomes. The objective of our study was to evaluate the impact of thirteen adjuvants (Intralipid, steroids, melatonin, coenzyme Q10, Filgrastim, testosterone, DHEA, growth hormone, antibiotics, hCG infusion, aspirin, enoxaparin/heparin and dopamine agonists) on the success of embryo transfers. Methods: This is a retrospective cohort study of all embryo transfers between January 2010 and April 2015 from a multi-site IVF clinic...
October 2017: Journal of Reproduction & Infertility
https://www.readbyqxmd.com/read/29200074/survival-of-staphylococcus-epidermidis-in-propofol-and-intralipid-in-the-dead-space-of-intravenous-injection-ports
#8
Ronan M N Noble, Saad Y Salim, Bradley Walker, Rachel G Khadaroo, Angelo B Chiarella, Ferrante S Gragasin, Stephane L Bourque
We tested whether propofol or Intralipid inoculated with Staphylococcus epidermidis would promote bacterial growth within an intravenous (IV) injection hub, a site prone to bacterial contamination. In tubes incubated under optimal conditions, S epidermidis exhibited growth in Intralipid, but not in propofol. In contrast, within the IV hub incubated with either propofol or intralipid at room temperature, S epidermidis bacterial numbers declined with time, and virtually no contamination remained after 12 hours...
November 30, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29170482/a-new-approach-to-deliver-anti-cancer-nanodrugs-with-reduced-off-target-toxicities-and-improved-efficiency-by-temporarily-blunting-the-reticuloendothelial-system-with-intralipid
#9
Li Liu, Qing Ye, Maggie Lu, Shih-Ta Chen, Hsiang-Wen Tseng, Ya-Chin Lo, Chien Ho
We have developed a new strategy to temporarily blunt the reticuloendothelial system uptake of nanodrugs, a major challenge for nanodrug delivery and causing off-target toxicities, using an FDA approved nutrition supplement, Intralipid. We have tested our methodology in rats using an experimental platinum-containing anti-cancer nanodrug and three FDA approved nanodrugs, Abraxane, Marqibo, and Onivyde, to determine their toxicities in liver, spleen, and kidney, with and without the addition of Intralipid. Our method illustrates its potentials to deliver nanodrugs with an increase in the bioavailability and a decrease in toxicities...
November 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29162669/non-labelled-lens-less-micro-endoscopic-approach-for-cellular-imaging-through-highly-scattering-media
#10
Omer Wagner, Aditya Pandya, Yoav Chemla, Hadar Pinhas, Irina Schelkanova, Asaf Shahmoon, Yossi Mandel, Alexandre Douplik, Zeev Zalevsky
We describe an imaging approach based on an optical setup made up of a miniature, lensless, minimally invasive endoscope scanning a sample and matching post processing techniques that enables enhanced imaging capabilities. The main scopes of this article are that this approach enables imaging beyond highly scattering medium and increases the resolution and signal to noise levels reaching single cell imaging. Our approach has more advantages over ordinary endoscope setups and other imaging techniques. It is not mechanically limited by a lens, the fiber can acquire images over long time periods (unlike current imaging methods such as OCT etc...
November 21, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/29161210/index-use-of-smoflipid-in-a-tertiary-intestinal-rehabilitation-and-transplantation-program
#11
Kwai Lam, Thomas Schiano, Maria Isabel Fiel, Kishore Iyer
Long-term parenteral nutrition (PN) may be complicated by PN-associated liver disease (PNALD), and some studies suggest an association between the use of soy-based fat emulsions and PNALD development. Patients' liver function typically improves and PNALD resolves after reducing or stopping a soy-based fat emulsion, and thus lipid minimization has been the primary strategy for managing PNALD in many intestinal rehabilitation programs. However, fat emulsions often cannot be stopped entirely, leading some patients to develop PNALD even after lipid reduction strategies have been implemented...
November 2017: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29145932/lipid-emulsion-more-than-reversing-bupivacaine-cardiotoxicity-potential-organ-protection
#12
Negar Motayagheni, Sheshanna Phan, Ala Nozari, Anthony Atala
Efforts to develop a treatment for bupivacaine cardiotoxicity led to the discovery that Intralipid, a popular brand of intravenous lipid emulsion, could be used not only as an effective treatment for anesthetic-induced cardiac arrest, but also as a means of reversing many other toxicities. Contradictory data exist regarding the mechanism of action of lipid emulsion, a combination of fatty acids traditionally used in parenteral nutrition. Some researchers attribute the effects to lipophilicity and the individual characteristics of the lipids, while other data demonstrate a direct empowering mechanism through cellular upstream and downstream pathways...
2017: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29126197/impaired-insulin-action-is-associated-with-increased-glucagon-concentrations-in-non-diabetic-humans
#13
Anu Sharma, Ron T Varghese, Meera Shah, Chiara Dalla Man, Claudio Cobelli, Robert A Rizza, Kent R Bailey, Adrian Vella
Context: Abnormal glucagon concentrations contribute to hyperglycemia but the mechanism(s) of α-cell dysfunction in prediabetes are unclear. Objective: We sought to determine the relative contributions of insulin secretion and action to α-cell dysfunction in non-diabetic subjects across the spectrum of glucose tolerance. Design: This was a cross-sectional study. A subset of subjects (n = 120) was studied in the presence and absence of free fatty acid (FFA) elevation, achieved by infusion of intralipid + heparin, to cause insulin resistance...
November 6, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29122557/-maternal-deaths-due-to-anesthesia-complications-results-from-the-french-confidential-enquiry-into-maternal-deaths-2010-2012
#14
D Chassard
Over the period 2010-2012, maternal mortality linked to anesthesia accounted for 2% of maternal deaths, with no significant change since 2007-2009. Of the 7 maternal deaths analyzed by the expert committee, anesthetic complications were in 5 cases the main cause of death: 4 attributed to direct causes related to anesthetic procedures during childbirth and 1 to indirect cause in connection with an ENT complication during pregnancy. The anesthetic causes of maternal mortality were for the 2010-2012 period: cardiac arrest under spinal anesthesia during caesarean section, local anesthetic intoxication with unsuccessful resuscitation after cardiac arrest without intralipid administration, acute respiratory distress syndrome in the postpartum period after pulmonary aspiration during caesarean section, cardiac arrest during caesarean section under general anesthesia in a context of non-Hodgkin lymphoma with mediastinal syndrome, unsuccessful endotracheal intubation in a context of cellulitis of the oral cavity floor...
November 6, 2017: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/29121078/indocyanine-green-fluorescence-in-second-near-infrared-nir-ii-window
#15
Zbigniew Starosolski, Rohan Bhavane, Ketan B Ghaghada, Sanjeev A Vasudevan, Alexander Kaay, Ananth Annapragada
Indocyanine green (ICG), a FDA approved near infrared (NIR) fluorescent agent, is used in the clinic for a variety of applications including lymphangiography, intra-operative lymph node identification, tumor imaging, superficial vascular imaging, and marking ischemic tissues. These applications operate in the so-called "NIR-I" window (700-900 nm). Recently, imaging in the "NIR-II" window (1000-1700 nm) has attracted attention since, at longer wavelengths, photon absorption, and scattering effects by tissue components are reduced, making it possible to image deeper into the underlying tissue...
2017: PloS One
https://www.readbyqxmd.com/read/29118840/too-many-pills-to-swallow-a-case-of-a-mixed-overdose
#16
Louise Emily Hopkins, Jonathan Sunkersing, Andrew Jacques
Propranolol is a highly lipid-soluble beta-receptor antagonist. We describe a case of mixed overdose, including propranolol, amlodipine and olanzapine, resulting in severe resistant hypotension which was successfully treated. A 21-year-old student ingested 6.4 g of propranolol, 280 mg of amlodipine and 560 mg of olanzapine. The patient was brought to the emergency department and exhibited signs of severe systemic toxicity - profound hypotension and circulatory collapse, respiratory depression and coma...
August 2017: Journal of the Intensive Care Society
https://www.readbyqxmd.com/read/29095868/effect-of-plasma-free-fatty-acid-supply-on-the-rate-of-ceramide-synthesis-in-different-muscle-types-in-the-rat
#17
Piotr Zabielski, Agnieszka Urszula Błachnio-Zabielska, Beata Wójcik, Adrian Chabowski, Jan Górski
Ceramide is a key compound in sphingolipid metabolism. Dynamics of ceramide synthesis is important in the several biological processes, such as induction of apoptosis or insulin resistance. So far, its de novo synthesis rate was evaluated indirectly, based on the content of the compound, its intermediates and the activity of respective enzymes. The aim of the present study was to directly measure ceramide synthesis rate (FSR) in different muscle types under varied plasma FFA supply in rat with the use of [U-13C] palmitate tracer and LC/MS/MS...
2017: PloS One
https://www.readbyqxmd.com/read/29079315/a-comparison-of-lipid-minimization-strategies-in-children-with-intestinal-failure
#18
Jessica Gonzalez-Hernandez, Purvi Prajapati, Gerald Ogola, Van Nguyen, Nandini Channabasappa, Hannah G Piper
PURPOSE: The purpose of this study was to compare outcomes of lipid minimization with either Intralipid (IL) or Omegaven® in children with intestinal failure (IF) who developed intestinal failure-associated liver disease (IFALD) while receiving parenteral nutrition (PN). METHODS: A retrospective review of children with IF requiring PN who developed IFALD (direct bilirubin >2 mg/dL) while receiving IL (2009-2016) was performed. Clinical characteristics, nutritional, and laboratory values were compared between children treated with reduced IL or Omegaven®...
October 12, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29062792/elevated-levels-of-serum-vascular-endothelial-growth-factor-a-are-not-related-to-nk-cell-parameters-in-recurrent-ivf-failure
#19
Rhea Bansal, Brian Ford, Shree Bhaskaran, Meenyau Thum, Amolak Bansal
BACKGROUND: Vascular Endothelial Growth Factor and NK cells have an interrelated role in angiogenesis that is critical for placentation and success of in vitro fertilization. An attempt was made to assess a possible relationship between the two in this study. METHODS: A case control study was performed comparing the serum levels of VEGF-A and its receptor VEGF-R1 with levels of NK cells, activated NK cells and NK cytotoxicity in 62 women with Repeated Implantation Failure (RIF)...
July 2017: Journal of Reproduction & Infertility
https://www.readbyqxmd.com/read/29047692/glucose-sensing-in-oral-mucosa-simulating-phantom-using-differential-absorption-based-frequency-domain-low-coherence-interferometry
#20
Pauline John, Nilesh J Vasa, Sujatha Narayanan Unni, Suresh R Rao
The superluminescent diode based differential absorption frequency domain low-coherence interferometry (FD-DALCI) technique is proposed and demonstrated for sensing physiological concentrations of glucose (0-250 mg/dl) in oral mucosa simulating phantoms (intralipid of concentrations 0.25-0.50%) with wavelengths at 1589 and 1310 nm. The proposed technique allows simultaneous measurements of refractive index based spectral shift and estimation of physiological concentration of glucose in intralipid with scattering characteristics using the differential absorption approach...
October 10, 2017: Applied Optics
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