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Post-polio sequelae

Carolyn P Da Silva, C Lauren Szot, Natasha deSa
PURPOSE: The purpose was to explore the feasibility of whole body vibration (WBV) on polio survivors with/without post-polio syndrome (PPS) by studying its effects on walking speed (10-m walk test), endurance (2-min walk test), pain severity/interference (Brief Pain Inventory [BPI]), sleep quality (Pittsburg Sleep Quality Index), fatigue (Fatigue Severity Scale), leg strength (manual muscle testing and hand-held dynamometry), and muscle cramping (written logs). METHODS: Fifteen individuals completed the study, participating in eight sessions in two 4-week blocks...
March 29, 2018: Physiotherapy Theory and Practice
Lalitendu Mohanty, Sunil Sharma, Beauty Behera, Sachin Panwar, Charu Paliwal, Anu Gupta, Deepak Chandra Chilkoti, Anit Singh
Immunogenicity and safety of a newly developed liquid DTwP-Hib/HepB-IPV hexavalent vaccine (EasySix™) was evaluated and compared with administration of commercially licensed Pentavac SD® (DTwP-HepB/Hib) and Imovax Polio® vaccine in an open-label, randomized multi-centric trial. 284 participants, aged 6-10weeks, randomized in a 1:1 allocation, received three doses of test or comparator vaccines, administered 4weeks apart. Immunogenicity of the vaccines was determined by measuring the baseline and post-vaccination antibody responses and comparing the proportions of subjects achieving seroprotection against the vaccine antigens; safety was evaluated in terms of solicited (local and systemic) and unsolicited incidences in the follow up phase...
April 19, 2018: Vaccine
Hamed Ahmed Elkhayat, Omnia Fathy El-Rashidy, Iman Ali Elagouza, Raghda Zaitoun, Yasser Abdel Azeem Abbas
Describing the variable clinical features, laboratory findings, neuroimaging findings, and treatments given to children who presented with ADEM and following them up both clinically and radiologically. 21 patients were recruited: 14 new cases, and 7 old ones presenting over the preceding 5 years (retrospective review of existing data). 11 males and 10 females, with a mean age of 4.4 years ± 2.7 SD, were included. All new patients were subject to full history, examination and a panel of investigations including MRI of the brain...
December 8, 2017: Acta Neurologica Belgica
L Bertolasi, A Danese, S Monaco, M Turri, K Borg, L Werhagen
BACKGROUND: Poliomyelitis was before the immunization an important medical problem. Nowadays polio prior patients (PP) suffer from polio sequelae or have developed post-polio-syndrome (PPS) with increasing paresis, pain and fatigue. OBJECTIVES: To analyze the medical situation 50 years after acute polio. The degree of paresis was compared between the recovery 1952-1961 and 2012.The prevalence of patients fulfilling the criteria for PPS was estimated. METHOD: The study was performed in Italy...
2016: Open Neurology Journal
Margaret M Peel, Marie Cooke, Helen J Lewis-Peel, Rodney A Lea, Wendy Moyle
OBJECTIVE: To determine if coenzyme Q(10) alleviates fatigue in the late-onset sequelae of poliomyelitis. DESIGN: Parallel-group, randomized, placebo-controlled trial. BACKGROUND SETTING: Coenzyme Q(10) has been shown to boost muscle energy metabolism in post-polio subjects but it does not promote muscle strength, endurance or function in polio survivors with post-poliomyelitis syndrome. However, the collective increased energy metabolism might contribute to a reduction in post-polio fatigue...
December 2015: Complementary Therapies in Medicine
Ryosuke Oki, Akiko Uchino, Yuishin Izumi, Hirohisa Ogawa, Shigeo Murayama, Ryuji Kaji
We report the case of a 72-year-old man who had contracted acute paralytic poliomyelitis in his childhood. Thereafter, he had suffered from paresis involving the left lower limb, with no relapse or progression of the disease. He began noticing slowly progressive muscle weakness and atrophy in the upper and lower extremities in his 60s. At the age of 72, muscle weakness developed rapidly, and he demonstrated dyspnea on exertion and dysphagia. He died after about 14 years from the onset of muscle weakness symptoms...
2016: Rinshō Shinkeigaku, Clinical Neurology
Lise Kay
Approximately 7,000 Danes are still living with sequelae after surviving an acute polio infection. Late effects of polio include deformities, arthrosis and overloaded muscles. In the long run polio patients are at risk of having a further decrease of muscle function and a wide variety of other symptoms, a condition called post-polio syndrome (PPS). Treatment of PPS is in general symptomatic. Recently it has been shown that treatment with intravenous immunoglobulin may have an effect on pain, tiredness and walking distance...
October 20, 2014: Ugeskrift for Laeger
Susana Collado-Vázquez, Jesús M Carrillo, Ana M Águila-Maturana
INTRODUCTION: Poliomyelitis is an infectious disease whose initial symptoms are fever, fatigue, headaches, vomiting, a stiff neck and pains in the limbs. In many cases, the sequelae are irreversible paralysis and may result in death if there is bulbar or respiratory compromise. A set of symptoms, called post-polio syndrome, which appears years after the acute infection, are also described. AIM: To analyse the way poliomyelitis has been dealt with in literature, cinema and television...
October 1, 2014: Revista de Neurologia
Isabella Schwartz, Irina Gartsman, Bella Adler, Yechiel Friedlander, Orly Manor, Hagai Levine, Zeev Meiner
OBJECTIVE: To evaluate the association between self-reported severity of polio sequelae and current functional status among polio survivors. METHODS: This was a cross sectional study of 195 polio survivors attending a polio outpatient clinic at a university hospital. The main outcome measures of demographic, medical, social, and functional data were gleaned from a questionnaire adapted for the polio population. The severity of polio sequelae was evaluated with the self-reported Index of Post-Polio Sequelae (IPPS)...
October 15, 2014: Journal of the Neurological Sciences
Hatice Kumru, Enric Portell, Manuela Barrio, Joan Santamaria
BACKGROUND: No studies have examined the association between RLS and the sequelae of poliomyelitis (PM). We studied the frequency and severity of RLS in a group of consecutive patients with the sequelae of poliomyelitis (PM) and the effect of treatment with dopaminergic drugs. METHODS: A diagnosis of RLS was made according to the criteria of the International RLS Study Group, and severity was assessed by the RLS rating scale. Information on sex, age, age at onset, site affected by PM, disease duration of PM, and history of post-polio syndrome (pPS) was obtained in a cohort of 52 PM patients...
October 2014: Parkinsonism & related Disorders
M T Westbrook
An Australia-wide questionnaire survey was conducted of 318 people who contracted polio between 1907 and 1962. It examined their medical histories, post-polio symptoms, effects of these symptoms on respondent's lives, and treatments found to be effective or ineffective. The average respondent was experiencing increasing muscle weakness, pain and fatigue. These imposed major restrictions on daily living activities and resulted in fear and depression. Physiotherapists were the allied health professionals most likely to be consulted...
1991: Australian Journal of Physiotherapy
Aditya Krishna Mootha, Priyanka Majety, Vishal Kumar
Isolated coronal fracture of medial femoral condyle with intact lateral femoral condyle is extremely rare. A high index of suspicion is necessary for early diagnosis especially in cases of undisplaced fractures. Here we report a case of medial Hoffa fracture in a post-polio limb presenting as chronic pain. Management of such fractures in limbs affected by late sequelae of poliomyelitis is particularly problematic in view of osteoporosis and osseous hypoplasia. The fracture was approached through medial parapatellar arthrotomy and fixation was done with cannulated cancellous screws in anteroposterior direction...
2014: Chinese Journal of Traumatology, Zhonghua Chuang Shang za Zhi
Nora Ellen Groce, Lena Morgon Banks, Michael Ashley Stein
Excitement mounts as the global health and international development communities anticipate a polio-free world. Despite substantial political and logistical hurdles, only 223 cases of wild poliovirus in three countries were reported in 2012. Down 99% from the estimated 350,000 annual cases in 125 countries in 1988-this decline signals the imminent global eradication of polio. However, elimination of new polio cases should not also signal an end to worldwide engagement with polio. As many as 20 million continue to live with the disabling consequences of the disease...
April 2014: Social Science & Medicine
Saurabh Kumar Bhattacharya, Radha Saraswathy, E Sivakumar
Environmental pollution is a complex issue because of the diversity of anthropogenic agents, both chemical and physical, that have been detected and catalogued. The consequences to biota from exposure to genotoxic agents present an additional problem because of the potential for these agents to produce adverse change at the cellular and organism levels. Past studies in virus have focused on structural damage to the DNA of environmental species that may occur after exposure to genotoxic agents and the use of this information to document exposure and to monitor remediation...
July 2011: Human & Experimental Toxicology
F-C Boyer, V Tiffreau, A Rapin, I Laffont, L Percebois-Macadré, C Supper, J-L Novella, A-P Yelnik
Post-polio syndrome (PPS) refers to a clinical disorder affecting polio survivors with sequelae years after the initial polio attack. These patients report new musculoskeletal symptoms, loss of muscular strength or endurance. PPS patients are tired, in pain and experience new and unusual muscular deficits, on healthy muscles as well as deficient muscles initially affected by the Poliovirus. Once a clinical diagnosis is established, the therapeutic options can be discussed. Some pathophysiological mechanisms have been validated by research studies on PPS (inflammatory process in cerebrospinal fluid [CSF] and cytokines of the immune system)...
February 2010: Annals of Physical and Rehabilitation Medicine
I Laffont, M Julia, V Tiffreau, A Yelnik, C Herisson, J Pelissier
OBJECTIVE: We estimate that there are about 50,000 persons who survived poliomyelitis in their childhood in France (mean age estimated between 50 and 65 years). After a few decades of stability, 30 to 65% of individuals who had been infected and recovered from polio begin to experience new signs and symptoms. METHOD: Review of the literature on Pubmed with the following keywords "Poliomyelitis" and "Post-Polio Syndrome (PPS)". RESULTS: These new signs and symptoms are characterized by muscular atrophy (decreased muscle mass), muscle weakness and fatigue, muscle and/or joint pain...
February 2010: Annals of Physical and Rehabilitation Medicine
Loek van Alphen
Since the early days of Jenner, vaccination against infectious agents appeared a very efficacious way for preventing millions of deaths and patients with serious sequelae. However, only limited success has been obtained in eradicating infectious diseases. Smallpox is the only human infectious disease that has been eradicated so far by vaccination, and eradication of polio is in its endgame. Data from the WHO in 2003 show that 2.5 million children under five still die from vaccine preventable diseases, but many more die from the major microbial killers in the world, i...
November 2009: Human Vaccines
Carin Willén, Anna-Lisa Thorén-Jönsson, Gunnar Grimby, Katharina Stibrant Sunnerhagen
OBJECTIVE: To evaluate changes over time in a clinically based cohort of individuals with post-polio syndrome. DESIGN: A prospective longitudinal study. SUBJECTS: A total of 106 individuals with poliomyelitis sequelae were included in the study. They were self-referred or had been referred to the post-polio clinic. After 4 years subjects were called for a follow-up and underwent the same measurements as at the initial assessment. METHODS: The following measurements were conducted at both the initial assessment, and the follow-up: questionnaires including Nottingham Health Profile, muscle strength and walking speed...
March 2007: Journal of Rehabilitation Medicine
G Kjartansson, S Ingadóttir, B Halldórsdóttir, A Gunnarsdóttir, G Guðmundsson, E O Einarsson, T Gíslason
OBJECTIVE: To describe the users of home mechanical ventilation treatment in Iceland. MATERIAL AND METHODS: Records for all patients in Iceland using noninvasive ventilatory support at home on April 30th 1999 were analysed. RESULTS: A total of 54 patients were using ventilatory support at home. There were 33 males and 21 females. The mean age for the group was 61 years. The mean treatment time was 3.5 years. The majority were using pressure controlled ventilators that were connected to a nose mask or full face mask...
June 2001: Læknablađiđ
C Bouza, J M Amate
INTRODUCTION: Post-polio syndrome (PPS) is recognised as a clinical syndrome that causes the late, progressive functional impairment suffered by survivors of an acute episode of poliomyelitis. The importance of PPS is acknowledged by increasingly wider sectors of the population and health care sectors; nevertheless, few reports have been published about its epidemiology or its clinical characteristics and treatment. AIM: To review the current scientific evidence available on the clinical manifestations, risk factors, prevalence, diagnosis and recommendations for treatment of PPS...
September 1, 2006: Revista de Neurologia
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