keyword
https://read.qxmd.com/read/38533769/activin-e-is-a-tgf%C3%AE-ligand-that-signals-specifically-through-activin-receptor-like-kinase-7
#1
JOURNAL ARTICLE
Kylie A Vestal, Chandramohan Kattamuri, Muhasin Koyiloth, Luisina Ongaro, James A Howard, Aimee Deaton, Simina Ticau, Aditi Dubey, Daniel J Bernard, Thomas B Thompson
Activins are one of the three distinct subclasses within the greater Transforming Growth Factor β (TGFβ) superfamily. First discovered for their critical roles in reproductive biology, activins have since been shown to alter cellular differentiation and proliferation. At present, members of the activin subclass include activin A (ActA), ActB, ActC, ActE, and the more distant members myostatin and GDF11. While the biological roles and signaling mechanisms of most activins class members have been well-studied, the signaling potential of ActE has remained largely unknown...
March 27, 2024: Biochemical Journal
https://read.qxmd.com/read/38532848/corneal-foreign-body-post-laser-in-situ-keratomileusis-diagnosis-management-outcome-and-review-of-literature
#2
Mona Bhargava, Varsha Bhambhani, Ahana Sen, Aditi Johri
PURPOSE: To report a case of metallic corneal foreign-body (CFB) penetrating the Laser in situ keratomileusis (LASIK) flap and its successful outcome. To highlight usefulness of Anterior Segment Optical Coherence Tomography (ASOCT) in diagnosis and management of post-LASIK CFB. To enumerate other similar cases published in literature. METHOD: A 30-year-old male presented to the emergency department of a tertiary eye care centre with a metallic CFB. He had undergone uneventful LASIK elsewhere 4-years back...
June 2024: American Journal of Ophthalmology Case Reports
https://read.qxmd.com/read/38529599/phenyliodine-bis-trifluoroacetate-as-a-sustainable-reagent-exploring-its-significance-in-organic-synthesis
#3
REVIEW
Sumit Kumar, Aditi Arora, Sunil K Singh, Rajesh Kumar, Bhawani Shankar, Brajendra K Singh
Iodine-containing molecules, especially hypervalent iodine compounds, have gained significant attention in organic synthesis. They are valuable and sustainable reagents, leading to a remarkable surge in their use for chemical transformations. One such hypervalent iodine compound, phenyliodine bis(trifluoroacetate)/bis(trifluoroacetoxy)iodobenzene, commonly referred to as PIFA, has emerged as a prominent candidate due to its attributes of facile manipulation, moderate reactivity, low toxicity, and ready availability...
March 26, 2024: Organic & Biomolecular Chemistry
https://read.qxmd.com/read/38528891/a-multilingual-sexual-and-reproductive-health-animation-a-novel-educational-tool-for-newcomer-patients
#4
JOURNAL ARTICLE
Aditi Sivakumar, Karla Willows, Sepideh Behroozan, Jocelyn Stairs
Newcomer populations face many barriers accessing healthcare, including language barriers. Language-concordant care has been shown to enhance equity and optimize health outcomes for underserved populations. This paper describes a sexual and reproductive health (SRH) animation for newcomer populations. The animation was created collaboratively by the Department of Obstetrics and Gynaecology Global Health Unit, the Halifax Newcomer Health Clinic, and student volunteers. Integrating this animation into other healthcare settings may help improve inclusion, trust, and patient-centred care for newcomer patients...
February 2024: Canadian Medical Education Journal
https://read.qxmd.com/read/38528182/regulation-of-zbp1-by-mir-99b-5p-in-microglia-controls-the-development-of-schizophrenia-like-symptoms-in-mice
#5
JOURNAL ARTICLE
Lalit Kaurani, Md Rezaul Islam, Urs Heilbronner, Dennis M Krüger, Jiayin Zhou, Aditi Methi, Judith Strauss, Ranjit Pradhan, Sophie Schröder, Susanne Burkhardt, Anna-Lena Schuetz, Tonatiuh Pena, Lena Erlebach, Anika Bühler, Monika Budde, Fanny Senner, Mojtaba Oraki Kohshour, Eva C Schulte, Max Schmauß, Eva Z Reininghaus, Georg Juckel, Deborah Kronenberg-Versteeg, Ivana Delalle, Francesca Odoardi, Alexander Flügel, Thomas G Schulze, Peter Falkai, Farahnaz Sananbenesi, Andre Fischer
Current approaches to the treatment of schizophrenia have mainly focused on the protein-coding part of the genome; in this context, the roles of microRNAs have received less attention. In the present study, we analyze the microRNAome in the blood and postmortem brains of schizophrenia patients, showing that the expression of miR-99b-5p is downregulated in both the prefrontal cortex and blood of patients. Lowering the amount of miR-99b-5p in mice leads to both schizophrenia-like phenotypes and inflammatory processes that are linked to synaptic pruning in microglia...
March 25, 2024: EMBO Journal
https://read.qxmd.com/read/38525600/efficient-axonal-transport-of-endolysosomes-relies-on-the-balanced-ratio-of-microtubule-tyrosination-and-detyrosination
#6
JOURNAL ARTICLE
Anja Konietzny, Yuhao Han, Yannes Popp, Bas van Bommel, Aditi Sharma, Philippe Delagrange, Nicolas Arbez, Marie-Jo Moutin, Leticia Peris, Marina Mikhaylova
In neurons, the microtubule (MT) cytoskeleton forms the basis for long-distance protein transport from the cell body into and out of dendrites and axons. To maintain neuronal polarity, the axon initial segment (AIS) serves as a physical barrier, separating the axon from the somatodendritic compartment and acting as a filter for axonal cargo. Selective trafficking is further instructed by axonal enrichment of MT post-translational modifications, which affect MT dynamics and the activity of motor proteins. Here, we compared two knockout mouse lines lacking the respective enzymes for MT tyrosination and detyrosination and found that both knockouts led to a shortening of the AIS...
March 25, 2024: Journal of Cell Science
https://read.qxmd.com/read/38525214/link-between-individual-resilience-and-aggressiveness-in-dental-students-and-the-mediating-effect-of-spirituality-a-path-analysis
#7
JOURNAL ARTICLE
Shamim Anjum, Gaurav Mishra, Nishita Kankane, Jitendra Khetan, Namrata Mahajan, Aditi Patel, Kumar G Chhabra
BACKGROUND: The role of spirituality in people's lives, particularly the lives of health professionals, as well as its impact on mental health issues like anger and aggressiveness and resilience, are particularly significant. Therefore, the purpose of this study was to examine the link between the propensity for violence and personal resilience in dental students by taking into account the function of spirituality as a mediator. MATERIALS AND METHODS: In this cross-sectional questionnaire survey, 211 volunteer dentistry students participated from a government institute in Jammu and Kashmir, India using a stratified sample procedure...
2024: Journal of Education and Health Promotion
https://read.qxmd.com/read/38524029/assessment-of-the-practices-and-perspectives-of-healthcare-providers-towards-utilization-of-telemedicine-for-the-care-of-adult-patients-with-diabetes-mellitus-during-the-covid-19-pandemic-in-india
#8
JOURNAL ARTICLE
Shubham Atal, Sowrabha Bhat, Sayan Kumar Das, Rajnish Joshi, Aditi Pandit Kabde, Aishwarya Krishnamurthy, Tejal Lathia, Balakrishnan Sadasivam, Rukiya Surya Shaikh
Background and purpose The lockdowns and restrictions enforced periodically during the COVID-19 pandemic posed a serious challenge for non-COVID care, especially in diabetes where telediabetes, the utilization of telemedicine consultations for diabetic care, became more necessary than ever before. Although studies have shed light on the perception of patients, there is a paucity of studies from the perspective of healthcare providers, especially in an Indian context. Moving forward, it is imperative to understand the perspectives of telediabetes providers in this domain...
February 2024: Curēus
https://read.qxmd.com/read/38520594/a-pilot-study-to-assess-blood-brain-barrier-permeability-in-long-covid
#9
JOURNAL ARTICLE
Aditi Gupta, Branden Comfort, Kate Young, Robert Montgomery
The etiology of brain fog associated with long COVID is not clear. Based on some preliminary work, disruption of the blood-brain barrier has been hypothesized, but has not been tested in patients with long COVID. In this case-control pilot study, we evaluated blood-brain barrier permeability in patients with long COVID and subjective memory loss or brain fog. We used 99 m Technetium diethylenetriaminepentaacetic acid single-photon emission computed tomography (SPECT) to measure blood-brain barrier permeability and a telephone assessment (T-cog) to measure cognitive function...
March 23, 2024: Brain Imaging and Behavior
https://read.qxmd.com/read/38517005/the-indian-academy-of-pediatrics-and-directorate-general-of-health-services-government-of-india-white-paper-on-transition-of-care-for-youth-with-special-health-care-needs
#10
JOURNAL ARTICLE
Jagdish Chandra, Mamta Manglani, Satinder Aneja, K P Vinayan, Aditi Sinha, Piali Mandal, Devendra Mishra, Rajeev Seth, Upendra Kinjawadekar
Over the years, survival of children with chronic diseases has significantly improved and a large proportion of them now are entering into adult hood. Transition of Care (ToC) of such patients with having childhood onset of chronic diseases to the adult health care system is well organized in developed countries, although it is an emerging concept in India. In situations where the systems for ToC are not in place, such cases are fraught with unsatisfactory health outcomes. With proper ToC in place, these patients are likely to receive uninterrupted care by the adult care physicians and hence reach their full potential...
March 19, 2024: Indian Pediatrics
https://read.qxmd.com/read/38514590/dietary-composition-and-time-in-range-in-population-with-type-2-diabetes-mellitus-exploring-the-association-using-continuous-glucose-monitoring-device
#11
JOURNAL ARTICLE
Aditi R Deshmane, Arti S Muley
AIM: To understand the association between macronutrient composition of a diet with Time in Range (TIR), Time above Range (TAR) and Time below Range (TBR) derived using a Continuous Glucose Monitoring (CGM) device for 14 days. METHODOLOGY: An exploratory analysis on the baseline data of 50 Type 2 Diabetes Mellitus participants with age 25-55 years, HbA1c upto 8% and on Metformin only) enrolled for an interventional clinical trial was performed. RESULTS: Participants consuming adequate carbohydrates (CHO) of 55 to 60% of total calories had better Average Blood Glucose of 142...
March 21, 2024: Endocrine
https://read.qxmd.com/read/38513887/guide-to-lung-protective-ventilation-in-cardiac-patients
#12
REVIEW
Aniket S Rali, Lena Tran, Aditi Balakrishna, Mourad Senussi, Navin K Kapur, Thomas Metkus, Ryan J Tedford, JoAnn Lindenfeld
Incidence of acute respiratory insufficiency has continued to increase amongst patients admitted to modern day cardiovascular intensive care units. Positive pressure ventilation (PPV) remains the mainstay of treatment for these patients. Alterations in intrathoracic pressure during PPV has distinct effects on both the right and left ventricle affecting cardiovascular performance. Lung protective ventilation (LPV) minimizes the risk of further lung injury through ventilator induced lung injury and hence an understanding of LPV and its cardiopulmonary interactions is beneficial for cardiologists...
March 19, 2024: Journal of Cardiac Failure
https://read.qxmd.com/read/38512283/subclinical-inflammation-in-asymptomatic-schoolchildren-with-plasmodium-falciparum-parasitemia-correlates-with-impaired-cognition
#13
JOURNAL ARTICLE
Alexander E Johnson, Aditi Upadhye, Veronicah Knight, Erik L Gaskin, Lindsey B Turnbull, David Ayuku, Mark Nyalumbe, Emily Abuonji, Chandy C John, Megan S McHenry, Tuan M Tran, George Ayodo
BACKGROUND: Subclinical inflammation and cognitive deficits have been separately associated with asymptomatic Plasmodium falciparum infections in schoolchildren. However, whether parasite-induced inflammation is associated with worse cognition has not been addressed. We conducted a cross-sectional pilot study to better assess the effect of asymptomatic P. falciparum parasitemia and inflammation on cognition in Kenyan schoolchildren. METHODS: We enrolled 240 children aged 7-14 years residing in high malaria transmission in Western Kenya...
March 21, 2024: Journal of the Pediatric Infectious Diseases Society
https://read.qxmd.com/read/38511015/clinicopathological-and-oncological-outcomes-of-borderline-mucinous-tumours-of-ovary-a-large-case-series
#14
JOURNAL ARTICLE
T S Shylasree, Devyani Mahajan, Aditi Chaturvedi, Santosh Menon, Stuti Gupta, Meenakshi Thakur, Pabashi Poddar, Amita Maheshwari
The objective is to study the clinico-demographic profile, treatment patterns and oncological outcomes in borderline mucinous tumours of the ovary. Retrospective cohort analysis was carried out between January 2017 and December 2019 for patients with a diagnosis of borderline mucinous tumours of the ovary who were treated at our centre. Kaplan-Meier method was used for the estimation of the probability of DFS and OS. Univariate and multivariate analyses based on the Cox proportional hazard model were performed to identify factors associated with DFS and OS...
March 2024: Indian Journal of Surgical Oncology
https://read.qxmd.com/read/38510883/gait-training-with-motor-relearning-program-in-conjunction-with-functional-electrical-stimulation-in-quadriparesis-secondary-to-cervical-and-lumbar-myelopathy
#15
Aditi Akhuj, Nishigandha P Deodhe, Shrushti Jachak
Degenerative cervical myelopathy is a frequently encountered age-related pathology following compression of the spinal cord. This case report delineates the clinical manifestation of cervical and lumbar myelopathy in a 78-year-old male patient, characterised by chief complaints of difficulty in moving bilateral upper and lower extremities and difficulty in bed mobility. Motor impairment can manifest in three different presentations, which are paraparesis, hemiparesis, or quadriparesis. The motor relearning program incorporating functional electrical stimulation constitutes a rehabilitative approach used for the restoration of motor function...
February 2024: Curēus
https://read.qxmd.com/read/38503043/mesothelioma-pleural-version-1-2024
#16
JOURNAL ARTICLE
James Stevenson, David S Ettinger, Douglas E Wood, Dara L Aisner, Wallace Akerley, Jessica R Bauman, Ankit Bharat, Debora S Bruno, Joe Y Chang, Lucian R Chirieac, Malcolm DeCamp, Aakash Desai, Thomas J Dilling, Jonathan Dowell, Gregory A Durm, Marina C Garassino, Scott Gettinger, Travis E Grotz, Matthew A Gubens, Rudy P Lackner, Michael Lanuti, Jules Lin, Billy W Loo, Christine M Lovly, Fabien Maldonado, Erminia Massarelli, Daniel Morgensztern, Trey C Mullikin, Thomas Ng, Gregory A Otterson, Dawn Owen, Sandip P Patel, Tejas Patil, Patricio M Polanco, Gregory J Riely, Jonathan Riess, Theresa A Shapiro, Aditi P Singh, Alda Tam, Tawee Tanvetyanon, Jane Yanagawa, Stephen C Yang, Edwin Yau, Kristina Gregory, Lisa Hang
Mesothelioma is a rare cancer that originates from the mesothelial surfaces of the pleura and other sites, and is estimated to occur in approximately 3,500 people in the United States annually. Pleural mesothelioma is the most common type and represents approximately 85% of these cases. The NCCN Guidelines for Mesothelioma: Pleural provide recommendations for the diagnosis, evaluation, treatment, and follow-up for patients with pleural mesothelioma. These NCCN Guidelines Insights highlight significant updates to the NCCN Guidelines for Mesothelioma: Pleural, including revised guidance on disease classification and systemic therapy options...
March 2024: Journal of the National Comprehensive Cancer Network: JNCCN
https://read.qxmd.com/read/38500292/phase-2-study-of-the-efficacy-and-safety-of-ponsegromab-in-patients-with-cancer-cachexia-proacc-1-study-design
#17
JOURNAL ARTICLE
John D Groarke, Jeffrey Crawford, Susie M Collins, Shannon L Lubaczewski, Danna M Breen, Magdalena A Harrington, Ira Jacobs, Ruolun Qiu, James Revkin, Michelle I Rossulek, Aditi R Saxena
BACKGROUND: Cancer cachexia is a multifactorial metabolic wasting syndrome characterized by anorexia, unintentional loss of weight involving both skeletal muscle and adipose tissues, progressive functional impairment and reduced survival. Therapeutic strategies for this serious condition are very limited. Growth differentiation factor 15 (GDF-15) is a cytokine that is implicated in cancer cachexia and may represent both a biomarker of cancer cachexia and a potential therapeutic target...
March 18, 2024: Journal of Cachexia, Sarcopenia and Muscle
https://read.qxmd.com/read/38497749/ann-multi-layer-perceptron-for-prediction-of-blood-brain-barrier-permeable-compounds-for-central-nervous-system-therapeutics
#18
JOURNAL ARTICLE
Aditi Sharma, Subathra Selvam, Priya Dharshini Balaji, Thirumurthy Madhavan
Endothelial cells produce a semipermeable barrier known as the blood-brain barrier (BBB) to keep undesired chemicals out of the central nervous system (CNS). However, this barrier also restricts the exploration of potential new medications due to insufficient exposure. To address this challenge, machine learning (ML) algorithms can be useful to predict the BBB permeability of chemical compounds. Support vector machines, continuous neural networks, and deep learning approaches have been used to identify compounds that can penetrate the BBB...
March 18, 2024: Journal of Biomolecular Structure & Dynamics
https://read.qxmd.com/read/38496625/pf-bacteriophages-hinder-sputum-antibiotic-diffusion-via-electrostatic-binding
#19
Qingquan Chen, Pam Cai, Tony Hong Wei Chang, Elizabeth Burgener, Michael J Kratochvil, Aditi Gupta, Aviv Hargil, Patrick R Secor, Josefine Eilsø Nielsen, Annelise E Barron, Carlos Milla, Sarah C Heilshorn, Andy Spakowitz, Paul L Bollyky
UNLABELLED: Despite great progress in the field, chronic Pseudomonas aeruginosa ( Pa ) infections remain a major cause of morbidity and mortality in patients with cystic fibrosis, necessitating treatment with inhaled antibiotics. Pf phage is a filamentous bacteriophage produced by Pa that has been reported to act as a structural element in Pa biofilms. Pf presence has been associated with resistance to antibiotics and poor outcomes in cystic fibrosis, though the underlying mechanisms are unclear...
March 10, 2024: bioRxiv
https://read.qxmd.com/read/38496175/in-the-shadows-of-motherhood-a-comprehensive-review-of-postpartum-depression-screening-and-intervention-practices
#20
REVIEW
Aishwarya Gupta, Sandhya Pajai, Anusha Gupta, Aditi Singh Thakur, Shaikh Muneeba, Nitish Batra, Dharmesh J Patel
This comprehensive review delves into the multifaceted landscape of postpartum depression (PPD), exploring its prevalence, impact on maternal and infant well-being, and the efficacy of existing screening and intervention practices. PPD emerges as a critical concern, with implications extending beyond individual mental health to encompass the dynamics of mother-infant relationships and societal well-being. The analysis underscores the complexity of addressing PPD, emphasizing the challenges associated with screening tools and the importance of evidence-based interventions...
February 2024: Curēus
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