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https://www.readbyqxmd.com/read/28816646/chronic-cigarette-smoke-mediated-global-changes-in-lung-mucoepidermoid-cells-a-phosphoproteomic-analysis
#1
Hitendra S Solanki, Jayshree Advani, Aafaque Ahmad Khan, Aneesha Radhakrishnan, Nandini A Sahasrabuddhe, Sneha M Pinto, Xiaofei Chang, Thottethodi Subrahmanya Keshava Prasad, Premendu Prakash Mathur, David Sidransky, Harsha Gowda, Aditi Chatterjee
Proteomics analysis of chronic cigarette smoke exposure is a rapidly emerging postgenomics research field. While smoking is a major cause of lung cancer, functional studies using proteomics approaches could enrich our mechanistic understanding of the elusive lung cancer global molecular signaling and cigarette smoke relationship. We report in this study on a stable isotope labeling by amino acids in cell culture-based quantitative phosphoproteomic analysis of a human lung mucoepidermoid carcinoma cell line, H292 cells, chronically exposed to cigarette smoke...
August 2017: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/28816189/effect-of-different-dentifrices-on-the-surface-roughness-of-acrylic-resins-an-in-vitro-study
#2
Nitin Gautam, Aditi Sharma, Unjum Bashir, Sisir Rapolu, Nallamilli Mamatha, Siripurapu Sravani
AIM: This study was undertaken to study the effect of three most commonly used dentifrices for denture cleaning and to find out any positive association between number of strokes by toothbrush and surface roughness of acrylic resin. MATERIALS AND METHODS: About 40 acrylic rectangular blocks with high finish were polished until surface roughness was calculated as 0 pirn. The materials tested were distilled water as a control group, Patanjali Dant Kanti, Colgate Total Cream, and Cleansodent as dentifrices...
August 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28806450/evaluation-of-combination-measles-mumps-rubella-varicella-vaccine-introduction-in-australia
#3
Kristine Macartney, Heather F Gidding, Lieu Trinh, Han Wang, Aditi Dey, Brynley Hull, Karen Orr, Jocelynne McRae, Peter Richmond, Michael Gold, Nigel Crawford, Jennifer A Kynaston, Peter McIntyre, Nicholas Wood
Importance: Incorporating combination vaccines, such as the measles-mumps-rubella-varicella (MMRV) vaccine, into immunization schedules should be evaluated from a benefit-risk perspective. Use of MMRV vaccine poses challenges due to a recognized increased risk of febrile seizures (FSs) when used as the first dose in the second year of life. Conversely, completion by age 2 years of measles, mumps, rubella, and varicella immunization may offer improved disease control. Objective: To evaluate the effect on safety and coverage of earlier (age 18 months) scheduling of MMRV vaccine as the second dose of measles-containing vaccine (MCV) in Australia...
August 14, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28806200/quality-of-anticoagulation-control-and-hemorrhage-risk-among-african-american-and-european-american-warfarin-users
#4
Nita A Limdi, Todd M Brown, Aditi Shendre, Nianjun Liu, Charles E Hill, Timothy M Beasley
OBJECTIVE: We evaluated whether percent time in target range (PTTR), risk of over-anticoagulation [international normalized ratio (INR)>4], and risk of hemorrhage differ by race. As PTTR is a strong predictor of hemorrhage risk, we also determined the influence of PTTR on the risk of hemorrhage by race. PARTICIPANTS AND METHODS: Among 1326 warfarin users, PTTR was calculated as the percentage of interpolated INR values within the target range of 2.0-3.0. PTTR was also categorized as poor (PTTR<60%), good (60≤PTTR<70%), or excellent (PTTR≥70%) anticoagulation control...
August 11, 2017: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/28805485/transcriptional-activity-of-transposable-elements-may-contribute-to-gene-expression-changes-in-the-syncytium-formed-by-cyst-nematode-in-arabidopsis-roots
#5
Sarbottam Piya, Morgan Bennett, Aditi Rambani, Tarek Hewezi
Transposable elements (TEs) are mobile genetic materials that constitute a large fraction of plant genomes. Recent experimental evidences indicate that TEs can play key regulatory roles in controlling the expression of adjacent genes during plant development and stress responses. Nevertheless, information about the transcriptional activity of TEs and their impact on proximal genes during plant-nematode interaction remains largely unknown. Here, we identify of differentially expressed TEs and report their possible influence on the expression of nearby genes during the susceptible interaction between the beet cyst nematode Heterodera schachtii and Arabidopsis thaliana...
August 14, 2017: Plant Signaling & Behavior
https://www.readbyqxmd.com/read/28800888/clinical-classification-of-post-anoxic-myoclonic-status
#6
Yara Mikhaeil-Demo, Jay R Gavvala, Irena I Bellinski, Micheal P Macken, Aditi Narechania, Jessica W Templer, Stephen VanHaerents, Stephan U Schuele, Elizabeth E Gerard
INTRODUCTION: Despite decades of research into the prognostic significance of post anoxic myoclonic status (MS), no consistent definition has been used to describe its clinical appearance. We set out to characterize the clinical features of MS and hypothesized that there are distinct clinical subtypes that may have prognostic implications. METHODS: Video EEG reports from 2008 to 2016 were searched to identify adult patients with post anoxic MS defined as persistent myoclonus for >30minutes beginning within 3days of cardiac arrest in a comatose patient...
August 8, 2017: Resuscitation
https://www.readbyqxmd.com/read/28798760/striking-the-right-chord-signaling-enigma-during-root-gravitropism
#7
REVIEW
Manjul Singh, Aditi Gupta, Ashverya Laxmi
Plants being sessile can often be judged as passive acceptors of their environment. However, plants are actually even more active in responding to the factors from their surroundings. Plants do not have eyes, ears or vestibular system like animals, still they "know" which way is up and which way is down? This is facilitated by receptor molecules within plant which perceive changes in internal and external conditions such as light, touch, obstacles; and initiate signaling pathways that enable the plant to react...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28794653/real-world-utilization-of-once-daily-extended-release-abuse-deterrent-formulation-of-hydrocodone-a-comparison-with-the-pre-approval-randomized-clinical-trials
#8
Louise Taber, T Christopher Bond, Xuezhe Wang, Aditi Kadakia, Tracy J Mayne
BACKGROUND AND OBJECTIVE: Hydrocodone bitartrate extended release (Hysingla(®) ER, HYD) was previously studied in a 12-week randomized, double-blind, placebo-controlled trial and a 52-week open-label safety study. Both of these preapproval studies allowed dose titration to efficacy. The purpose of the present analysis was to compare dosing and utilization patterns in these previous clinical trials with real-world data (RWD) usage in a retrospective claim analysis performed 12-14 months post approval in the US...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28791482/assessment-of-ki67-expression-for-breast-cancer-subtype-classification-and-prognosis-in-the-nurses-health-study
#9
Megan A Healey, Kelly A Hirko, Andrew H Beck, Laura C Collins, Stuart J Schnitt, A Heather Eliassen, Michelle D Holmes, Rulla M Tamimi, Aditi Hazra
PURPOSE: Ki67 is a proliferation marker commonly assessed by immunohistochemistry in breast cancer, and it has been proposed as a clinical marker for subtype classification, prognosis, and prediction of therapeutic response. However, the clinical utility of Ki67 is limited by the lack of consensus on the optimal cut point for each application. METHODS: We assessed Ki67 by immunohistochemistry using Definiens digital image analysis (DIA) in 2653 cases of incident invasive breast cancer diagnosed in the Nurses' Health Study from 1976 to 2006...
August 8, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28782314/association-of-environmental-factors-prevalence-of-asthma-and-respiratory-morbidity-in-mumbai-need-of-a-public-health-policy
#10
Amita Athavale, Hariharan Iyer, Aditi D Punwani, Jeenam J Shah, Gita Natraj, Jairaj P Nair, Rakesh Kumar, Lakshmi R Menon, Aparna N Iyer, Sagar J Raiya
OBJECTIVE: To study the association between environmental factors, prevalence of asthma and respiratory morbidity in relation to air quality levels in a mega city. To study modifiable environmental factors in people with diagnosed asthma and increased respiratory morbidity. METHODS: Cross sectional survey of population (N-3233) from 6 localities near air quality stations was done to study prevalence of asthma and respiratory morbidity (n-1006) followed by case control study of environmental factors by air sampling to study biological contamination...
June 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28779882/magnitude-temporal-trends-and-projections-of-the-global-prevalence-of-blindness-and-distance-and-near-vision-impairment-a-systematic-review-and-meta-analysis
#11
Rupert R A Bourne, Seth R Flaxman, Tasanee Braithwaite, Maria V Cicinelli, Aditi Das, Jost B Jonas, Jill Keeffe, John H Kempen, Janet Leasher, Hans Limburg, Kovin Naidoo, Konrad Pesudovs, Serge Resnikoff, Alex Silvester, Gretchen A Stevens, Nina Tahhan, Tien Y Wong, Hugh R Taylor
BACKGROUND: Global and regional prevalence estimates for blindness and vision impairment are important for the development of public health policies. We aimed to provide global estimates, trends, and projections of global blindness and vision impairment. METHODS: We did a systematic review and meta-analysis of population-based datasets relevant to global vision impairment and blindness that were published between 1980 and 2015. We fitted hierarchical models to estimate the prevalence (by age, country, and sex), in 2015, of mild visual impairment (presenting visual acuity worse than 6/12 to 6/18 inclusive), moderate to severe visual impairment (presenting visual acuity worse than 6/18 to 3/60 inclusive), blindness (presenting visual acuity worse than 3/60), and functional presbyopia (defined as presenting near vision worse than N6 or N8 at 40 cm when best-corrected distance visual acuity was better than 6/12)...
August 2, 2017: Lancet Global Health
https://www.readbyqxmd.com/read/28776279/asparagine-synthetase-deficiency-report-of-a-novel-mutation-and-review-of-literature
#12
Neerja Gupta, Vishal Vishnu Tewari, Manoj Kumar, Nitika Langeh, Aditi Gupta, Pallavi Mishra, Punit Kaur, Vedam Ramprasad, Sakthivel Murugan, Reema Kumar, Manisha Jana, Madhulika Kabra
Asparagine synthetase deficiency is a rare inborn error of metabolism caused by a defect in ASNS, a gene encoding asparagine synthetase. It manifests with a severe neurological phenotype manifesting as severe developmental delay, congenital microcephaly, spasticity and refractory seizures. To date, nineteen patients from twelve unrelated families have been identified. Majority of the mutations are missense and nonsense mutations in homozygous or compound heterozygous state. We add another case from India which harbored a novel homozygous missense variation in exon 11 and compare the current case with previously reported cases...
August 3, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28772065/ultrawide-field-scanning-laser-ophthalmoscopy-imaging-of-lipemia-retinalis
#13
Paolo S Silva, Aditi Gupta, Radwan S Ajlan, Deborah K Schlossman, Ann M Tolson, Jerry D Cavallerano, Lloyd Paul Aiello
OBJECTIVE: To describe the characteristic retinal features of lipemia retinalis when using ultrawide field scanning laser ophthalmoscopy. MAIN POINTS: We report a case series of three subjects with ultrawide field retinal images showing cream discoloration of the fundus, light salmon-coloured posterior retinal vessels and greyish pink peripheral vasculature. On green-only imaging, many of the vessels appear light rather than typically dark. CONCLUSION: Lipemia retinalis is readily apparent on ultrawide field imaging and illustrates the alterations that systemic diseases may induce in the posterior and peripheral retinal vasculature...
August 3, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28771602/affordable-care-act-and-healthcare-delivery-a-comparison-of-california-and-florida-hospitals-and-emergency-departments
#14
Monique T Barakat, Aditi Mithal, Robert J Huang, Alka Mithal, Amrita Sehgal, Subhas Banerjee, Gurkirpal Singh
IMPORTANCE: The Affordable Care Act (ACA) has expanded access to health insurance for millions of Americans, but the impact of Medicaid expansion on healthcare delivery and utilization remains uncertain. OBJECTIVE: To determine the early impact of the Medicaid expansion component of ACA on hospital and ED utilization in California, a state that implemented the Medicaid expansion component of ACA and Florida, a state that did not. DESIGN: Analyze all ED encounters and hospitalizations in California and Florida from 2009 to 2014 and evaluate trends by payer and diagnostic category...
2017: PloS One
https://www.readbyqxmd.com/read/28766098/perceived-barriers-and-preferred-components-for-physical-activity-interventions-in-african-american-survivors-of-breast-or-endometrial-cancer-with-type-2-diabetes-the-s-u-c-c-e-s-s-framework
#15
Kristin Z Black, La-Shell Johnson, Carmen D Samuel-Hodge, Lavanya Gupta, Aditi Sundaresan, Wanda K Nicholson
PURPOSE: African-American (AA) female cancer survivors share a disproportionate burden of diabetes compared to their white counterparts. Our objectives were to explore the perspectives of AA survivors with type 2 diabetes on perceived barriers to physical activity (PA) and preferences for a PA intervention and develop a framework for a PA program after cancer treatment. METHODS: Trained interviewers conducted semi-structured interviews with AA survivors of breast or endometrial cancer with diabetes (total n = 20; 16 breast, 4 endometrial)...
August 1, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28764305/a-wide-spread-red-lesion-on-the-surface-of-the-tongue-a-case-report-and-review-of-differential-diagnosis
#16
Yenduluri Durga Bai, Sathasivasubramanian Sankarapandian, R Aditi
The tongue is considered to be the strongest muscular organ in the body and a very important structure in the oral cavity. It is involved in various critical functions such as taste, speech, chewing and deglutition. It has been known to be a harbinger of systemic health and disease. Lesions occurring on the tongue vary widely in colour and consistency. Widespread red lesions on the tongue need to be differentiated carefully from each other for a proper diagnosis and treatment and must be followed up for recurrence...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28761894/gastric-pneumatosis-from-isolated-gastric-calciphylaxis
#17
Aditi Mulgund, Sanam Razeghi, Sampath Poreddy
A 58-year-old man with end-stage renal disease presented with hypotension and emesis, pale conjunctivae, and a distended abdomen. Labs revealed hypercalcemia and leukocytosis. Abdominal imaging showed gastric pneumatosis. Endoscopy demonstrated significant hemorrhage and necrosis in the gastric cardia and fundus. Biopsies revealed acute ulcerative gastritis and focal intravascular calcium phosphate crystals. The patient remained nil per os and was placed on omeprazole and sucralfate. Repeat endoscopy demonstrated mucosal healing...
2017: ACG Case Reports Journal
https://www.readbyqxmd.com/read/28761215/comparison-of-a1c-to-oral-glucose-tolerance-test-for-the-diagnosis-of-prediabetes-in-overweight-and-obese-youth
#18
Aditi Khokhar, Gayathri Naraparaju, Miriam Friedman, Sheila Perez-Colon, Vatcharapan Umpaichitra, Vivian L Chin
IN BRIEF This study reports performance of A1C against the oral glucose tolerance test (OGTT) in predicting prediabetes among overweight and obese African-American and Caribbean children. A retrospective chart review was completed for 230 children. Receiver operating characteristic curves were generated to find the predictive performances of different tests against the OGTT. A1C alone is a poor discriminator of prediabetes in our study population, with low sensitivity (70%) and specificity (48.8%). BMI z score, A1C, and homeostatic model assessment of insulin resistance are significant predictors of prediabetes and, when taken together, provide better discrimination for prediabetes...
July 2017: Clinical Diabetes: a Publication of the American Diabetes Association
https://www.readbyqxmd.com/read/28757836/prebronchoplasty-ventilation-maneuver-steering-the-outcome-in-the-management-of-bronchial-injuries
#19
Dheeraj Kapoor, Jasveer Singh, Aditi Jain, Manpreet Singh, Ashwani K Dalal
Bronchial injuries are infrequently seen following blunt chest trauma and mostly have subtle clinical presentation. Its diagnosis is challenging and may be delayed resulting in myriad complications such as secondary infection, bronchiectasis, atelectasis, collapse, and fibrosis. We discuss the anesthetic management of a case of complete right principle bronchus transection with distal lung collapse, posted for surgical repair and highlight the unique intraoperative ventilation maneuver to identify the functional lung segment...
July 2017: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/28757413/restoration-of-mir-30a-expression-inhibits-growth-tumorigenicity-of-medulloblastoma-cells-accompanied-by-autophagy-inhibition
#20
Satishkumar Vishram Singh, Aditi Nigam Dakhole, Akash Deogharkar, Sadaf Kazi, Rohan Kshirsagar, Atul Goel, Aliasgar Moiyadi, Rakesh Jalali, Epari Sridhar, Tejpal Gupta, Prakash Shetty, Nikhil Gadewal, Neelam Vishwanath Shirsat
Medulloblastoma is a highly malignant pediatric brain tumor. About 30% patients have metastasis at diagnosis and respond poorly to treatment. Those that survive, suffer long term neurocognitive, endocrine and developmental defects due to the cytotoxic treatment to developing child brain. It is therefore necessary to develop targeted treatment strategies based on underlying biology for effective treatment of medulloblastoma with minimal side effects. Medulloblastomas are believed to be the result of deregulated nervous system development as evident from the role of WNT and SHH developmental signaling pathways in pathogenesis of medulloblastomas...
July 27, 2017: Biochemical and Biophysical Research Communications
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