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https://www.readbyqxmd.com/read/27911948/tlr3-induced-maturation-of-murine-dendritic-cells-regulates-ctl-responses-by-modulating-pd-l1-trafficking
#1
Aditi Varthaman, Hélène D Moreau, Mathieu Maurin, Philippe Benaroch
Targeting TLR3 through formulations of polyI:C is widely studied as an adjuvant in cancer immunotherapy. The efficacy of such targeting has been shown to increase in combination with anti-PD-L1 treatment. Nevertheless, the mechanistic details of the effect of polyI:C on DC maturation and the impact on T-DC interactions upon PD-L1 blockade is largely unknown. Here we found that although DC treatment with polyI:C induced a potent inflammatory response including the production of type I interferon, polyI:C treatment of DCs impaired activation of peptide specific CD8+ T cells mainly due to PD-L1...
2016: PloS One
https://www.readbyqxmd.com/read/27901359/buprenorphine-transdermal-system-utilization
#2
Laura Wallace, Aditi Kadakia
OBJECTIVES: To evaluate utilization patterns in patients initiating buprenorphine transdermal system (BTDS), CIII, and estimate the proportion decreasing their total opioid dose over time. METHODS: This retrospective cohort study used data from the Truven Health Analytics MarketScan® Commercial Claims and Encounters Database from January 1, 2011 through December 31, 2015. Eligible individuals were adults aged 18-64 years newly dispensed BTDS (index prescription) who had at least six months of insurance coverage prior to (baseline period) and following (study period) the index prescription...
November 30, 2016: Postgraduate Medicine
https://www.readbyqxmd.com/read/27899952/prognostic-and-predictive-implications-of-sokal-euro-and-eutos-scores-in-chronic-myeloid-leukaemia-in-the-imatinib-era-experience-from-a-tertiary-oncology-centre-in-southern-india
#3
Lakshmaiah Chinnagiriyappa Kuntegowdanahalli, Govind Babu Kanakasetty, Aditi Harsh Thanky, Lokanatha Dasappa, Linu Abraham Jacob, Suresh Babu Mallekavu, Rajeev Krishnappa Lakkavalli, Lokesh N Kadabur, Rudresha Antapura Haleshappa
Chronic myeloid leukaemia (CML) is a myeloproliferative disorder. Over the years many prognostic models have been developed to better risk stratify this disease at baseline. Sokal, Euro, and EUTOS scores were developed in varied populations initially receiving various therapies. Here we try to identify their predictive and prognostic implication in a larger population of Indian patients with CML-CP (chronic phase) in the imatinib era.
2016: Ecancermedicalscience
https://www.readbyqxmd.com/read/27896663/significant-role-of-segmental-duplications-and-sidd-sites-in-chromosomal-translocations-of-hematological-malignancies-a-multi-parametric-bioinformatic-analysis
#4
Aditi Daga, Afzal Ansari, Medha Pandya, Krupa Shah, Shanaya Patel, Rakesh Rawal, Valentina Umrania
Recurrent non-random chromosomal translocations are hallmark characteristics of leukemogenesis, and however, molecular mechanisms underlying these rearrangements are less explored. The fundamental question is, why and how chromosomes break and reunite so precisely in the genome. Meticulous understanding of mechanism leading to chromosomal rearrangement can be achieved by characterizing breakpoints. To address this hypothesis, a novel multi-parametric computational approach for characterization of major leukemic translocations within and around breakpoint region was performed...
November 28, 2016: Interdisciplinary Sciences, Computational Life Sciences
https://www.readbyqxmd.com/read/27895571/neural-mechanisms-of-positive-mood-induced-modulation-of-reality-monitoring
#5
Karuna Subramaniam, Jeevit Gill, Patrick Slattery, Aditi Shastri, Daniel H Mathalon, Srikantan Nagarajan, Sophia Vinogradov
This study investigates the neural mechanisms of mood induced modulation of cognition, specifically, on reality monitoring abilities. Reality monitoring is the ability to accurately distinguish the source of self-generated information from externally-presented contextual information. When participants were in a positive mood, compared to a neutral mood, they significantly improved their source memory identification abilities, particularly for self-generated information. However, being in a negative mood had no effect on reality monitoring abilities...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27893529/the-role-of-theory-specific-techniques-and-therapeutic-alliance-in-promoting-positive-outcomes-integrative-psychotherapy-for-world-trade-center-responders
#6
Peter Tejas Haugen, Aditi Sinha Werth, Alyce Lauren Foster, Jesse Owen
World Trade Center responders demonstrate high symptom burden, underscoring the importance of refining treatment approaches for this cohort. One method is examining the impact of therapy techniques on outcomes, and the interactions between technique and alliance on outcomes. This study a) examined the interaction of early treatment techniques on integrative psychotherapy outcomes and b) explored whether associations differed at varying levels of alliance. Twenty-nine adult responders diagnosed with partial or full posttraumatic stress disorder received outpatient psychotherapy and completed weekly measures of alliance, technique, and symptom distress...
December 2016: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/27890977/health-and-socioeconomic-status-of-the-elderly-people-living-in-hilly-areas-of-pakhribas-kosi-zone-nepal
#7
Ankit Amar Gupta, Amrit Kumar Lall, Aditi Das, Anshu Saurav, Abnish Nandan, Deepa Shah, Anand Agrahari, Deepak Kumar Yadav
BACKGROUND: The rising geriatric population is facing significant health and social problems in the developing world that are impacting the quality of their lives. OBJECTIVE: The study describes the general health status and the socioeconomic characteristics of the elderly people of Pakhribas village development committee (VDC) of Eastern Nepal. MATERIALS AND METHODS: Descriptive cross-sectional study was carried out targeting the people aged 60 years and above in the sample area using a semi-structured questionnaire and convenient sampling to get the required sample size...
October 2016: Indian Journal of Community Medicine
https://www.readbyqxmd.com/read/27889928/elucidating-the-role-of-cyclooxygenase-2-in-the-pathogenesis-of-oral-lichen-planus-an-immunohistochemical-study-with-supportive-histochemical-analysis
#8
Pratyush Singh, Jasleen Grover, Aditi Amit Byatnal, Vasudeva Guddattu, Raghu Radhakrishnan, Monica Charlotte Solomon
OBJECTIVE: Oral lichen planus (OLP) is a chronic, inflammatory disorder that affects the oral mucous membrane. During an inflammatory response, several chemokines and cytokines are released by the cells of the immune system. Activation of MMPs, along with mast cell-derived chymase and tryptase, degrades the basement membrane structural proteins, resulting in basement membrane breaks. AIM: To investigate the association between the COX-2 expressions, presence of intact or degranulating mast cells within the connective tissue and the extent of basement membrane discontinuity in OLP cases...
November 7, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/27889724/phenotype-of-dent-disease-in-a-cohort-of-indian-children
#9
Swati Bhardwaj, Ranjeet Thergaonkar, Aditi Sinha, Pankaj Hari, Cheong Hi, Arvind Bagga
OBJECTIVE: To describe the clinical and genotypic features of Dent disease in children diagnosed at our center over a period of 10 years. DESIGN: Case series. SETTING: Pediatric Nephrology Clinic at a referral center in Northern India. METHODS: The medical records of patients with Dent disease diagnosed and followed up at this hospital from June 2005 to April 2015 were reviewed. The diagnosis of Dent disease was based on presence of all three of the following: (i) low molecular weight proteinuria, (ii) hypercalciuria and (iii) one of the following: nephrolithiasis, hematuria, hypophosphatemia or renal insufficiency, with or without mutation in CLCN5 or OCRL1 genes...
November 15, 2016: Indian Pediatrics
https://www.readbyqxmd.com/read/27881568/incident-type-2-myocardial-infarction-in-a-cohort-of-patients-undergoing-coronary-or-peripheral-arterial-angiography
#10
Hanna K Gaggin, Yuyin Liu, Asya Lyass, Roland R van Kimmenade, Shweta R Motiwala, Noreen Kelly, Aditi Mallick, Parul U Gandhi, Nasrien E Ibrahim, Mandy Simon, Anju Bhardwaj, Arianna Belcher, Jamie E Harisiades, Joseph M Massaro, Ralph B D'Agostino, James L Januzzi
BACKGROUND: -Despite growing recognition of Type 2 myocardial infarction (T2MI; related to supply-demand mismatch), little is known about its risk factors or its association with outcome. METHODS: -A single center cohort of patients undergoing coronary or peripheral angiography with or without intervention was prospectively enrolled and followed for incident type 1 and T2MI, as well as major adverse cardiovascular events (MACE, a composite of all-cause death, non-fatal MI, heart failure, stroke, transient ischemic attack, peripheral arterial complication and cardiac arrhythmia)...
November 21, 2016: Circulation
https://www.readbyqxmd.com/read/27879206/exon-junction-complex-proteins-bind-nascent-transcripts-independently-of-pre-mrna-splicing-in-drosophila-melanogaster
#11
Subhendu Roy Choudhury, Anand K Singh, Tina McLeod, Marco Blanchette, Boyun Jang, Paul Badenhorst, Aditi Kanhere, Saverio Brogna
Although it is currently understood that the exon junction complex (EJC) is recruited on spliced mRNA by a specific interaction between its central protein, eIF4AIII, and splicing factor CWC22, we found that eIF4AIII and the other EJC core proteins Y14 and MAGO bind the nascent transcripts of not only intron-containing but also intronless genes on Drosophila polytene chromosome. Additionally, Y14 ChIP-seq demonstrates that association with transcribed genes is also splicing-independent in Drosophila S2 cells...
November 23, 2016: ELife
https://www.readbyqxmd.com/read/27878829/genetic-association-of-plag1-scd-cyp7b1-and-fasn-snps-and-their-effects-on-carcass-weight-intramuscular-fat-and-fatty-acid-composition-in-hanwoo-steers-korean-cattle
#12
Hyun Joo Kim, Aditi Sharma, Soo Hyun Lee, Doo Ho Lee, Da Jeong Lim, Yong Min Cho, Boh Suk Yang, Seung Hwan Lee
No abstract text is available yet for this article.
November 22, 2016: Animal Genetics
https://www.readbyqxmd.com/read/27876203/impact-of-the-national-targeted-hepatitis-a-immunisation-program-in-australia-2000-2014
#13
Craig Thompson, Aditi Dey, Emily Fearnley, Benjamin Polkinghorne, Frank Beard
In November 2005, hepatitis A vaccine was funded under the Australian National Immunisation Program for Aboriginal and Torres Strait Islander (Indigenous) children aged 12-24months in the targeted jurisdictions of Queensland, South Australia, Western Australia and the Northern Territory. We reviewed the epidemiology of hepatitis A from 2000 to 2014 using data from the Australian National Notifiable Diseases Surveillance System, the National Hospital Morbidity Database, and Australian Bureau of Statistics causes-of-death data...
November 18, 2016: Vaccine
https://www.readbyqxmd.com/read/27875275/histone-chaperone-aplf-regulates-induction-of-pluripotency-in-murine-fibroblasts
#14
Khaja Mohieddin Syed, Sunu Joseph, Ananda Mukherjee, Aditi Majumder, Jose M Teixeira, Debasree Dutta, Madhavan Radhakrishna Pillai
Induction of pluripotency in differentiated cells by the exogenous expression of transcription factors, Oct4, Sox2, Klf4 and cMyc, involves reprogramming at the epigenetic level. Histones and their metabolism governed by histone chaperones constitute a significant aspect of epigenetics. We hypothesized that histone chaperones might facilitate or inhibit the course of reprogramming. For the first time, we report here that the downregulation of histone chaperone Aprataxin PNK-like factor (APLF) promotes reprogramming by augmenting the expression of E-cadherin (Cdh1), implicated in mesenchymal-to-epithelial transition (MET) involved in the generation of induced pluripotent stem cells (iPSCs) from mouse embryonic fibroblasts (MEFs)...
November 14, 2016: Journal of Cell Science
https://www.readbyqxmd.com/read/27871068/autoinflammatory-skin-disease-a-review-of-concepts-and-applications-to-general-dermatology
#15
Aditi S Murthy, Kieron Leslie
We provide an up-to-date summary of important concepts of autoinflammation as well as describe important but rare monogenic autoinflammatory disorders that may present with cutaneous findings. Finally, of particular interest to a practicing general dermatology audience, we review concepts of autoinflammation as they apply to understanding the disease pathogenesis of common skin disorders.
November 22, 2016: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/27864106/transurethral-resection-of-prostate-and-bleeding-a-prospective-randomized-double-blind-placebo-controlled-trial-to-see-efficacy-of-short-term-use-of-finasteride-and-dutasteride-on-operative-blood-loss-and-prostatic-micro-vessel-density
#16
Aditi Arora, Ankur Bansal, Bimalesh Purkait, Ashok Kumar Sokhal, Ved Bhaskar, Priyank Yadav, Satyanarayan Sankhwar
OBJECTIVE: To evaluate the effects of short term use of finasteride and dutasteride on amount of intraoperative blood loss and microvessel density (MVD) of prostatic stromal and suburethral tissues in patients with benign prostatic hyperplasia (BPH) prior to TURP METHODS: The study involved 450 male patients who planned to have TURP and were prospectively randomised into three groups (150 patients each). The group 1 received no medication, group 2 received finasteride 5 mg/day and group 3 received dutasteride 0...
November 15, 2016: Urology
https://www.readbyqxmd.com/read/27857767/exploring-the-missing-link-empathy-among-dental-students-an-institutional-cross-sectional-survey
#17
Vikram Pal Aggarwal, Robin Garg, Nikita Goyal, Puneet Kaur, Sakshi Singhal, Nancy Singla, Deeksha Gijwani, Aditi Sharma
BACKGROUND: Empathy plays an important role in healthy dentist and patient relationship. Hence, the aim of the study is to (a) to measure the self-reported empathy levels among dental undergraduate and postgraduate students. (b) To review the trend of changes in empathy level with experience, age, and gender among dental undergraduate and postgraduate students. MATERIALS AND METHODS: This cross-sectional, questionnaire-based study was carried out in two private dental institutions situated in Sri Ganganagar, India, with a sample size of 978...
September 2016: Dental Research Journal
https://www.readbyqxmd.com/read/27853937/may-high-mmp-2-and-timp-2-expressions-increase-or-decrease-the-aggressivity-of-oral-cancer
#18
Bijayatha Shrestha, Dipshikha Bajracharya, Aditi Amit Byatnal, Asha Kamath, Raghu Radhakrishnan
Matrix metalloproteinases-2 (MMP-2) and the tissue inhibitor of metalloproteinase-2 (TIMP-2), may presumably have an important role on the invasion and metastatic spread of malignancies attributed to an uncontrolled degradation of the extracellular matrix (ECM). A retrospective chart analysis was carried out to study the expression of MMP-2 and TIMP-2 on the archival samples of oral squamous cell carcinoma (OSCC) (n = 30) and normal mucosa (n = 10) by immunohistochemistry and compared with the clinicopathologic parameters of cases...
November 16, 2016: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/27852031/increasing-the-efficacy-of-radiotherapy-by-modulating-the-ccr2-ccr5-chemokine-axes
#19
Kelli A Connolly, Brian A Belt, Nathania M Figueroa, Aditi Murthy, Ankit Patel, Minsoo Kim, Edith M Lord, David C Linehan, Scott A Gerber
Although radiotherapy (RT) is widely used to control tumor growth across many cancer types, there is a relatively high incidence of RT failure exhibited by tumor recurrence, therefore a clear need exists to achieve improved effectiveness of RT. The RT-elicited immune response largely impacts the efficacy of RT and includes immune cells that kill tumor cells, but also immunosuppressive cells, which dampen anti-tumor immunity. Using murine models in which syngeneic tumor cell lines (Colon38, Glioma261, Line1) are grown intramuscularly and treated with 15 Gy local RT, we assessed the effects of RT on both the systemic and intratumoral immune response...
November 11, 2016: Oncotarget
https://www.readbyqxmd.com/read/27851139/1503-association-between-fluid-balance-daily-weight-measurements-and-surgical-intensive-care-outcomes
#20
Mustafa Al-Jubouri, Brandon Wilkinson, Mustafa Baldawi, Jenna Watson, Aditi Saraswat, Dragos Galusca
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
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