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https://www.readbyqxmd.com/read/28939980/targeted-exome-sequencing-in-anti-factor-h-antibody-negative-hus-reveals-multiple-variations
#1
R W Thergaonkar, Ankita Narang, Bahadur Singh Gurjar, Pradeep Tiwari, Mamta Puraswani, Himanshi Saini, Aditi Sinha, Binuja Varma, Mitali Mukerji, Pankaj Hari, Arvind Bagga
BACKGROUND: Genetic susceptibility to atypical hemolytic uremic syndrome (aHUS) may lie within genes regulating or activating the alternate complement and related pathways converging on endothelial cell activation. METHODS: We tested 32 Indian patients of aHUS negative for antibodies to complement factor H for genetic variations in a panel of 15 genes, i.e., CFH, CFHR1-5, CFI, CFB, C3, CD46, MASP2, DGKE, ADAMTS13, THBD and PLG using next-generation DNA sequencing and for copy number variation in CFHR1-3...
September 22, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/28938457/the-association-of-estrogen-receptor-%C3%AE-gene-variation-with-salt-sensitive-blood-pressure
#2
Worapaka Manosroi, Jia Wei Tan, Chevon M Rariy, Bei Sun, Mark O Goodarzi, Aditi R Saxena, Jonathan S Williams, Luminita H Pojoga, Jessica Lasky-Su, Jinrui Cui, Xiuqing Guo, Kent D Taylor, Yii-Der I Chen, Anny H Xiang, Willa A Hsueh, Leslie J Raffel, Thomas A Buchanan, Jerome I Rotter, Gordon H Williams, Ellen W Seely
Context: Hypertension in young women is uncommon compared to young men and older women. Estrogen appears to protect most women against hypertension with incidence increasing after menopause. Since some premenopausal women develop hypertension, estrogen may play a different role in these women. Genetic variations in the estrogen receptor (ER) are associated with cardiovascular disease. ER-β, encoded by ESR2, is the ER predominantly expressed in vascular smooth muscle. Objective: To determine an association of single nucleotide polymorphisms (SNPs) in ESR2 with salt-sensitivity of blood pressure (SSBP) and estrogen status in women...
September 5, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28934983/erratum-to-the-development-of-lower-respiratory-tract-microbiome-in-mice
#3
Nisha Singh, Asheema Vats, Aditi Sharma, Amit Arora, Ashwani Kumar
No abstract text is available yet for this article.
September 21, 2017: Microbiome
https://www.readbyqxmd.com/read/28929270/mode-of-treatment-governs-curcumin-response-on-doxorubicin-induced-toxicity-in-cardiomyoblasts
#4
Aditi Jain, Vibha Rani
Doxorubicin (Dox) is an effective anti-cancer drug with severe reported cardiotoxicity. Cardiovascular risks associated with present cancer therapeutics demand urgent attention. There has been a growing interest in naturally occurring compounds to improve the therapeutic index as well as prevent non-tumour tissues from sustaining chemotherapy-induced damages. In the present study, the effects of curcumin, a polyphenol isolated from Curcuma longa and well known for its anti-oxidative, anti-cancerous and anti-inflammatory properties, was studied in relation to the Dox-induced cardiotoxicity...
September 19, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28929063/lymph-node-central-necrosis-on-the-computed-tomography-as-the-predictor-of-the-extra-capsular-spread-in-metastatic-head-and-neck-squamous-cell-carcinoma
#5
Aditi Sharma, Ashwin Ashok Jaiswal, Girish Umredkar, Ratiram Barle, Neeta Sharma, Praveer Kumar Banerjee, Amrish Kumar Garg, Ravindranath Membally
The aim of this study is to investigate the relationship between the presence of the cervical lymph node with central necrosis as on the preoperative imaging and postoperative histopathological identification of the lymph node extra capsular spread. This study is a prospective study conducted at J.L.N. Hospital and Research Centre, Bhilai (C.G), from August 2011 to January 2014. Thirty patients with metastatic head and neck squamous cell carcinoma were enrolled. All candidates were subjected to a detailed history taking and clinical examination...
September 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/28926319/case-246-mr-imaging-of-a-complex-cystic-mass-in-a-newborn-girl
#6
Aditi Shruti, George S Wu
History A 6-day-old female neonate presented to the outpatient pediatric surgery clinic for evaluation of a possible prenatal abdominal mass. The neonate was delivered at term via cesarean section due to macrosomia, with a reported birth weight of 11 lb 8.7 oz (5.23 kg). The patient's postnatal course was remarkable for resolving neonatal hyperbilirubinemia. A physical examination was remarkable for a palpable mass in the abdomen. Maternal risk factors included class II obesity, type 2 diabetes, and metabolic syndrome...
October 2017: Radiology
https://www.readbyqxmd.com/read/28919530/coproduction-of-protease-and-mannanase-from-bacillus-nealsonii-pn-11-in-solid-state-fermentation-and-their-combined-application-as-detergent-additives
#7
Aditi David, Aditya Kumar, Steffy Angural, Deepak Kumar, Neena Puri, Naveen Gupta
Bacillus nealsonii PN-11 produces thermo-alkalistable mannanase and protease active in wide temperature and pH range. Optimization of coproduction of protease and mannanase from this strain and application of cocktail of these enzymes as detergent additives were studied. On optimization mannanase yield of 834Ug(-1) (11.12 fold increase) and protease yield of 70Ug(-1) (4.7 fold increase) could be obtained in a single fermentation. Purification and characterization of mannanase have been done earlier and protease was done during this study and has a molecular mass of 48kDa...
September 15, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28910304/comparative-proteomic-investigation-of-metastatic-and-non-metastatic-osteosarcoma-cells-of-human-and-canine-origin
#8
Jahnabi Roy, Kathryn L Wycislo, Holly Pondenis, Timothy M Fan, Aditi Das
Osteosarcoma is the most common bone cancer in dogs and people. In order to improve clinical outcomes, it is necessary to identify proteins that are differentially expressed by metastatic cells. Membrane bound proteins are responsible for multiple pro-metastatic functions. Therefore characterizing the differential expression of membranous proteins between metastatic and non-metastatic clonal variants will allow the discovery of druggable targets and consequently improve treatment methodology. The objective of this investigation was to systemically identify the membrane-associated proteomics of metastatic and non-metastatic variants of human and canine origin...
2017: PloS One
https://www.readbyqxmd.com/read/28899409/alcohol-consumption-and-breast-tumor-gene-expression
#9
Jun Wang, Yujing J Heng, A Heather Eliassen, Rulla M Tamimi, Aditi Hazra, Vincent J Carey, Christine B Ambrosone, Victor P de Andrade, Adam Brufsky, Fergus J Couch, Tari A King, Francesmary Modugno, Celine M Vachon, David J Hunter, Andrew H Beck, Susan E Hankinson
BACKGROUND: Alcohol consumption is an established risk factor for breast cancer and the association generally appears stronger among estrogen receptor (ER)-positive tumors. However, the biological mechanisms underlying this association are not completely understood. METHODS: We analyzed messenger RNA (mRNA) microarray data from both invasive breast tumors (N = 602) and tumor-adjacent normal tissues (N = 508) from participants diagnosed with breast cancer in the Nurses' Health Study (NHS) and NHSII...
September 12, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28893800/vhl-deficiency-drives-enhancer-activation-of-oncogenes-in-clear-cell-renal-cell-carcinoma
#10
Xiaosai Yao, Jing Tan, Kevin Junliang Lim, Joanna Koh, Wen Fong Ooi, Zhimei Li, Dachuan Huang, Manjie Xing, Yang Sun Chan, James Zhengzhong Qu, Su Ting Tay, Giovani Wijaya, Yue Ning Lam, Jing Han Hong, Ai Ping Lee-Lim, Peiyong Guan, Michelle Shu Wen Ng, Cassandra Zhengxuan He, Joyce Suling Lin, Tannistha Nandi, Aditi Qamra, Chang Xu, Swe Swe Myint, James O J Davies, Jian Yuan Goh, Gary Loh, Bryan C Tan, Steven G Rozen, Qiang Yu, Iain Bee Huat Tan, Christopher Wai Sam Cheng, Shang Li, Kenneth Tou En Chang, Puay Hoon Tan, David Lawrence Silver, Alexander Lezhava, Gertrud Steger, Jim R Hughes, Bin Tean Teh, Patrick Tan
Protein-coding mutations in clear cell renal cell carcinoma (ccRCC) have been extensively characterized, frequently involving inactivation of the von Hippel Lindau (VHL) tumor suppressor. Roles for non-coding cis-regulatory aberrations in ccRCC tumorigenesis, however, remain unclear. Analyzing 10 primary tumor/normal pairs and 9 cell lines across 79 chromatin profiles, we observed pervasive enhancer malfunction in ccRCC, with cognate enhancer-target genes associated with tissue-specific aspects of malignancy...
September 11, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/28893354/similar-virulence-properties-of-infection-and-colonization-associated-pseudomonas-aeruginosa
#11
Aditi, Malini Shariff, Sunil K Chhabra, Mujeeb-Ur Rahman
PURPOSE: Pseudomonas aeruginosa is one of the agents that are commonly implicated in nosocomial infections. However, it is also present as a commensal in various body sites of healthy persons, making the diagnosis of infection by culture difficult. A number of virulence factors expressed by the organism have been implicated in its pathogenicity. We undertook this study to identify the host and organism factors associated with infection. METHODOLOGY: Pathogenic, colonizing and environmental isolates were tested for apr, lasB, the T3SS effector exoenzymes (exoS, exoT, exoU and exoY) and toxA genes, biofilm production and antimicrobial susceptibility...
September 12, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28885979/adaptation-to-climate-change-a-comparative-analysis-of-modeling-methods-for-heat-related-mortality
#12
Simon N Gosling, David M Hondula, Aditi Bunker, Dolores Ibarreta, Junguo Liu, Xinxin Zhang, Rainer Sauerborn
BACKGROUND: Multiple methods are employed for modeling adaptation when projecting the impact of climate change on heat-related mortality. The sensitivity of impacts to each is unknown because they have never been systematically compared. In addition, little is known about the relative sensitivity of impacts to "adaptation uncertainty" (i.e., the inclusion/exclusion of adaptation modeling) relative to using multiple climate models and emissions scenarios. OBJECTIVES: This study had three aims: a) Compare the range in projected impacts that arises from using different adaptation modeling methods; b) compare the range in impacts that arises from adaptation uncertainty with ranges from using multiple climate models and emissions scenarios; c) recommend modeling method(s) to use in future impact assessments...
August 16, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28885456/tumor-necrosis-factor-alpha-secreted-from-oral-squamous-cell-carcinoma-contributes-to-cancer-pain-and-associated-inflammation
#13
Nicole N Scheff, Yi Ye, Aditi Bhattacharya, Justin MacRae, Dustin H Hickman, Atul K Sharma, John C Dolan, Brian L Schmidt
Oral cancer patients report severe pain during function. Inflammation plays a role in the oral cancer microenvironment; however, the role of immune cells and associated secretion of inflammatory mediators in oral cancer pain has not been well defined. In this study, we utilized two oral cancer mouse models: a cell line supernatant injection model and the 4-nitroquinoline-1-oxide (4NQO) chemical carcinogenesis model. We used the two models to study changes in immune cell infiltrate and orofacial nociception associated with oral squamous cell carcinoma (oSCC)...
September 1, 2017: Pain
https://www.readbyqxmd.com/read/28875262/erratum-to-asparagine-synthetase-deficiency-report-of-a-novel-mutation-and-review-of-literature
#14
Neerja Gupta, Vishal Vishnu Tewari, Manoj Kumar, Nitika Langeh, Aditi Gupta, Pallavi Mishra, Punit Kaur, Vedam Ramprasad, Sakthivel Murugan, Reema Kumar, Manisha Jana, Madhulika Kabra
No abstract text is available yet for this article.
September 5, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28874489/most-marketplace-plans-included-at-least-25%C3%A2-percent-of-local-area-physicians-but-enrollment-disparities-remained
#15
Aditi P Sen, Lena M Chen, Donald F Cox, Arnold M Epstein
The Affordable Care Act allows commercial insurers participating in the Marketplaces to vary the size of their provider networks as long as the providers are "sufficient" in numbers and types. Concerns have been growing over the increasing use of restricted-provider or narrow networks in Marketplace plans because of their implications for reduced access to care, but little is known about the breadth and stability of these networks over time or what types of enrollees choose such plans. Using national data, we found that in 2016, 60 percent of provider networks in plans offered in the federally facilitated Marketplaces included at least one-quarter of local-area physicians, and that consumers' access to broad-network plans remained stable between 2015 and 2016...
September 1, 2017: Health Affairs
https://www.readbyqxmd.com/read/28869701/nup42-and-ip6-coordinate-gle1-stimulation-of-dbp5-ddx19b-for-mrna-export-in-yeast-and-human-cells
#16
Rebecca L Adams, Aaron C Mason, Laura Glass, Aditi, Susan R Wente
The mRNA lifecycle is driven through spatiotemporal changes in the protein composition of mRNA particles (mRNPs) that are triggered by RNA-dependent DEAD-box protein (Dbp) ATPases. As mRNPs exit the nuclear pore complex (NPC) in Saccharomyces cerevisiae, this remodeling occurs through activation of Dbp5 by inositol hexakisphosphate (IP6 )-bound Gle1. At the NPC, Gle1 also binds Nup42, but Nup42's molecular function is unclear. Here we employ the power of structure-function analysis in S. cerevisiae and human (h) cells, and find that the high-affinity Nup42-Gle1 interaction is integral to Dbp5 (hDDX19B) activation and efficient mRNA export...
September 4, 2017: Traffic
https://www.readbyqxmd.com/read/28868585/spectrum-of-anca-associated-vasculitis
#17
REVIEW
Aditi Sinha, Arvind Bagga
No abstract text is available yet for this article.
September 4, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28867178/associations-of-erap1-coding-variants-and-domain-specific-interaction-with-hla-c%C3%A2-06-in-the-early-onset-psoriasis-patients-of-india
#18
Anamika Das, Aditi Chandra, Joyeeta Chakraborty, Abhijit Chattopadhyay, Swapan Senapati, Gobinda Chatterjee, Raghunath Chatterjee
Interferon-γ-induced aminopeptidase ERAP1 trims peptides within the endoplasmic reticulum so that they can be loaded onto MHC class I and presented to the CD8(+) T-cells. ERAP1 association and its interaction with HLA-C∗06 is controversial across different populations. We have investigated the association and possible functional role of non-synonymous SNPs at different exons of ERAP1 (rs26653: Arg127Pro, rs30187: Lys528Arg and rs27044: Gln730Glu) and their interactions with HLA-C∗06 in psoriasis. Significant associations of HLA-C∗06 (OR=5...
September 1, 2017: Human Immunology
https://www.readbyqxmd.com/read/28866639/over-expression-of-mirna-9-generates-muscle-hypercontraction-through-translational-repression-of-the-troponin-t-in-drosophila%C3%A2-indirect-flight-muscles
#19
Prasanna Katti, Divesh Thimmaya, Aditi Madan, Upendra Nongthomba
miRNAs are small non-coding endogenous RNAs, typically 21-23 nucleotides long, that regulate gene expression, usually post-transcriptionally by binding to the 3'-UTR of target mRNA, thus blocking translation. The expression of several miRNAs is significantly altered during cardiac hypertrophy, myocardial ischemia, fibrosis, heart failure and other cardiac myopathies. Recent studies have implicated miR-9 in myocardial hypertrophy. However a detailed mechanism remains obscure. In this study, we have addressed the roles of miR-9 in muscle development and function using the genetically tractable model system, the indirect flight muscles (IFMs) of Drosophila melanogaster Bioinformatics analysis identified 135 potential miR-9a targets, of which 27 genes were associated with Drosophila muscle development...
September 2, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/28865659/prioritizing-possibilities-for-child-and-family-health-an-agenda-to-address-adverse-childhood-experiences-and-foster-the-social-and-emotional-roots-of-well-being-in-pediatrics
#20
Christina D Bethell, Michele R Solloway, Stephanie Guinosso, Sandra Hassink, Aditi Srivastav, David Ford, Lisa A Simpson
OBJECTIVE: A convergence of theoretical and empirical evidence across many scientific disciplines reveals unprecedented possibilities to advance much needed improvements in child and family well-being by addressing adverse childhood experiences (ACEs), promoting resilience, and fostering nurturance and the social and emotional roots of healthy child development and lifelong health. In this article we synthesize recommendations from a structured, multiyear field-building and research, policy, and practice agenda setting process to address these issues in children's health services...
September 2017: Academic Pediatrics
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