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https://www.readbyqxmd.com/read/29139244/raman-exfoliative-cytology-for-oral-precancer-diagnosis
#1
Aditi Sahu, Poonam Gera, Venkatesh Pai, Abhishek Dubey, Gunjan Tyagi, Mandavi Waghmare, Sandeep Pagare, Manoj Mahimkar, C Murali Krishna
Oral premalignant lesions (OPLs) such as leukoplakia, erythroplakia, and oral submucous fibrosis, often precede oral cancer. Screening and management of these premalignant conditions can improve prognosis. Raman spectroscopy has previously demonstrated potential in the diagnosis of oral premalignant conditions (in vivo), detected viral infection, and identified cancer in both oral and cervical exfoliated cells (ex vivo). The potential of Raman exfoliative cytology (REC) in identifying premalignant conditions was investigated...
November 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29134694/intracorneal-haemorrhage-after-intravitreal-injections
#2
Aditi G Dastidar, Ravi D Barbhaya, Chinmayi Vyas, Kumar Saurabh, Rupak Roy
No abstract text is available yet for this article.
November 14, 2017: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/29133650/epidemiology-clinical-profile-and-factors-predicting-final-visual-outcome-of-pediatric-ocular-trauma-in-a-tertiary-eye-care-center-of-central-india
#3
Satendra Singh, Bhavana Sharma, Kavita Kumar, Aditi Dubey, Kanchan Ahirwar
PURPOSE: Ocular trauma constitutes an important cause of preventable visual morbidity worldwide. This study was done to study the incidence, sociodemographic pattern, and clinical profile of ocular trauma in pediatric age group. Also to evaluate the factors influencing final visual outcome in these patients. METHODS: This was a prospective interventional study concerning ocular trauma in pediatric patients up to 16 years of age of either sex. Various variables having an impact on final visual outcome were studied, and results were analyzed using statistical indices - relative risk, Chi-square test, P value, and linear regression analysis...
November 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29133052/design-and-synthesis-of-short-amphiphilic-cationic-peptidomimetics-based-on-biphenyl-backbone-as-antibacterial-agents
#4
Rajesh Kuppusamy, Muhammad Yasir, Thomas Berry, Charles G Cranfield, Shashidhar Nizalapur, Eugene Yee, Onder Kimyon, Aditi Taunk, Kitty K K Ho, Bruce Cornell, Mike Manefield, Mark Willcox, David StC Black, Naresh Kumar
Antimicrobial peptides (AMPs) and their synthetic mimics have received recent interest as new alternatives to traditional antibiotics in attempts to overcome the rise of antibiotic resistance in many microbes. AMPs are part of the natural defenses of most living organisms and they also have a unique mechanism of action against bacteria. Herein, a new series of short amphiphilic cationic peptidomimetics were synthesized by incorporating the 3'-amino-[1,1'-biphenyl]-3-carboxylic acid backbone to mimic the essential properties of natural AMPs...
November 10, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29132614/early-childhood-linear-growth-faltering-in-low-income-and-middle-income-countries-as-a-whole-population-condition-analysis-of-179-demographic-and-health-surveys-from-64-countries-1993-2015
#5
Daniel E Roth, Aditi Krishna, Michael Leung, Joy Shi, Diego G Bassani, Aluisio J D Barros
BACKGROUND: The causes of early childhood linear growth faltering (known as stunting) in low-income and middle-income countries remain inadequately understood. We aimed to determine if the progressive postnatal decline in mean height-for-age Z score (HAZ) in low-income and middle-income countries is driven by relatively slow growth of certain high-risk children versus faltering of the entire population. METHODS: Distributions of HAZ (based on WHO growth standards) were analysed in 3-month age intervals from 0 to 36 months of age in 179 Demographic and Health Surveys from 64 low-income and middle-income countries (1993-2015)...
December 2017: Lancet Global Health
https://www.readbyqxmd.com/read/29126492/oral-cancer-genetics-and-the-role-of-precision-medicine
#6
REVIEW
Chia-Cheng Li, Zhen Shen, Roxanne Bavarian, Fan Yang, Aditi Bhattacharya
Oral squamous cell carcinoma (OSCC) is one of the leading cancers in the world. OSCC patients are managed with surgery and/or chemoradiation. Prognoses and survival rates are dismal, however, and have not improved for more than 20 years. Recently, the concept of precision medicine was introduced, and the introduction of targeted therapeutics demonstrated promising outcomes. This article reviews the current understanding of initiation, progression, and metastasis of OSCC from both genetic and epigenetic perspectives...
January 2018: Dental Clinics of North America
https://www.readbyqxmd.com/read/29126249/the-encyclopedia-of-dna-elements-encode-data-portal-update
#7
Carrie A Davis, Benjamin C Hitz, Cricket A Sloan, Esther T Chan, Jean M Davidson, Idan Gabdank, Jason A Hilton, Kriti Jain, Ulugbek K Baymuradov, Aditi K Narayanan, Kathrina C Onate, Keenan Graham, Stuart R Miyasato, Timothy R Dreszer, J Seth Strattan, Otto Jolanki, Forrest Y Tanaka, J Michael Cherry
The Encyclopedia of DNA Elements (ENCODE) Data Coordinating Center has developed the ENCODE Portal database and website as the source for the data and metadata generated by the ENCODE Consortium. Two principles have motivated the design. First, experimental protocols, analytical procedures and the data themselves should be made publicly accessible through a coherent, web-based search and download interface. Second, the same interface should serve carefully curated metadata that record the provenance of the data and justify its interpretation in biological terms...
November 6, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29120332/levamisole-standard-or-intensive-therapy
#8
Aditi Sinha, Arvind Bagga
No abstract text is available yet for this article.
October 15, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/29120320/adapting-maternal-health-practice-to-co-morbidities-and-social-inequality-a-systematic-approach
#9
Aditi Iyer, V Srinidhi, Anuradha Sreevathsa, Gita Sen
The process of adapting universal guidelines to local institutional and cultural settings is recognized as important to their implementation and uptake. However, clarity on what, why and how to adapt in an evidence-based manner is still somewhat elusive. Health providers in low and middle income country contexts often have to deal with widely present co-morbidities and social inequalities among pregnant women. Since neither of these problems finds adequate discussion within the usual guidelines, and given the continual pressures posed by resource scarcity, health providers respond through ad hoc adaptations inimical to maternal safety and equity...
November 9, 2017: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
https://www.readbyqxmd.com/read/29116606/fanconi-syndrome-and-neonatal-diabetes-phenotypic-heterogeneity-in-patients-with-glut2-defects
#10
Priyanka Khandelwal, Aditi Sinha, Vandana Jain, Jayne Houghton, Pankaj Hari, Arvind Bagga
Fanconi-Bickel syndrome, caused by mutations in SLC2A2 encoding the glucose transporter 2 (GLUT2), is characterized by generalized proximal renal tubular dysfunction manifesting in late infancy. We describe phenotypic heterogeneity of Fanconi-Bickel syndrome in three siblings, including early and atypical presentation with transient neonatal diabetes mellitus in one. The second-born of a non-consanguineous couple, evaluated for polyuria and growth retardation, had rickets, hepatomegaly and proximal tubular dysfunction from 4 to 6  months of age...
November 8, 2017: CEN Case Reports
https://www.readbyqxmd.com/read/29113822/lack-of-tnf-%C3%AE-signaling-through-p55-makes-the-mice-more-susceptible-to-acute-infection-but-does-not-alter-state-of-latency-and-reactivation-of-hsv-1
#11
Aditi Mohankrishnan, Rajesh Parmar, Vishakha Bhurani, Sarat Kumar Dalai
TNF-α has been shown to play an important role in pathogenesis and latency of HSV-1 infections. TNF-α signals through TNFR1 (p55) and TNFR2 (p75), and signaling through p55 generally results in gene activation leading to induction of inflammatory responses. Here, we studied the role of TNF-α signaling in latent virus reactivation in p55-knock out (KO) mouse model of ocular HSV-1 infection. We found that KO mice are more susceptible to HSV-1 infection compared to wild type C57Bl/6 mice. While the absence of TNFRI signaling enhanced the ganglion latent DNA content by two folds, there was no difference in the maintenance and reactivation of latent HSV-1...
November 4, 2017: Virus Research
https://www.readbyqxmd.com/read/29108238/sites-of-extranodal-involvement-are-prognostic-in-patients-with-stage-1-follicular-lymphoma
#12
Aditi Shastri, Murali Janakiram, Ioannis Mantzaris, Yiting Yu, Jaime S Londono, Amit K Verma, Stefan K Barta
Objectives: Follicular lymphoma (FL) is the most common indolent B cell lymphoma in the United States and a quarter of patients present with stage I disease. The objective of this study was to examine if primary site of disease influences survival in early stage lymphoma. Results: The most common extranodal primary sites were the integumentary system (8%), followed by the GI tract (6.4%) and head & neck (5.6%). We stratified patients into a pre-rituximab era (1983-1998) and the rituximab era (1999-2011)...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29108133/targeted-delivery-of-mir-199a-3p-using-self-assembled-dipeptide-nanoparticles-efficiently-reduces-hepatocellular-carcinoma
#13
Aditi Varshney, Jiban J Panda, Avishek K Singh, Nitin Yadav, Chhagan Bihari, Subhrajit Biswas, Shiv K Sarin, Virander S Chauhan
Hepatocellular carcinoma (HCC) is an aggressive tumor with limited systemic and locoregional modalities of treatment. Although microRNA (miRNA) based therapies have significant potential, their targeted delivery remains a major challenge. miR-199a-3p functions as an important tumor suppressor in HCC, which regulates various cellular processes. Recently, peptide-based nanoparticles (NPs) have been developed to deliver oligonucleotides including miRNA. Here, we describe the synthesis and characterization of arginine α,β-dehydrophenylalanine (RΔF) nanoparticles for the selective delivery of miR-199a-3p to restore dysregulated gene expression in HCC...
November 6, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29102994/excess-burden-of-non-communicable-disease-years-of-life-lost-from-heat-in-rural-burkina-faso-a-time-series-analysis-of-the-years-2000-2010
#14
Aditi Bunker, Maquins Odhiambo Sewe, Ali Sié, Joacim Rocklöv, Rainer Sauerborn
OBJECTIVES: Investigate the association of heat exposure on years of life lost (YLL) from non-communicable diseases (NCD) in Nouna, Burkina Faso, between 2000 and 2010. DESIGN: Daily time series regression analysis using distributed lag non-linear models, assuming a quasi-Poisson distribution of YLL. SETTING: Nouna Health and Demographic Surveillance System, Kossi Province, Rural Burkina Faso. PARTICIPANTS: 18 367 NCD-YLL corresponding to 790 NCD deaths recorded in the Nouna Health and Demographic Surveillance Site register over 11 years...
November 4, 2017: BMJ Open
https://www.readbyqxmd.com/read/29092706/rates-of-hospitalisation-for-herpes-zoster-may-warrant-vaccinating-indigenous-australians-under-70
#15
Meru Sheel, Frank H Beard, Aditi Dey, Kristine Macartney, Peter B McIntyre
No abstract text is available yet for this article.
November 6, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/29083165/ultrafast-intersystem-crossing-in-acetylacetone-via-femtosecond-x-ray-transient-absorption-at-the-carbon-k-edge
#16
Aditi Bhattacherjee, Chaitanya Das Pemmaraju, Kirsten Schnorr, Andrew R Attar, Stephen R Leone
Molecular triplet states constitute a crucial gateway in the photochemical reactions of organic molecules by serving as a reservoir for the excess electronic energy. Here, we report the remarkable sensitivity of soft X-ray transient absorption spectroscopy for following the intricate electronic structure changes accompanying the non-adiabatic transition of an excited molecule from the singlet to the triplet manifold. Core-level X-ray spectroscopy at the carbon-1s K-edge (284 eV) is applied to identify the role of the triplet state (T1, (3)ππ*) in the ultraviolet-induced photochemistry of pentane-2,4-dione (acetylacetone, AcAc)...
November 9, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29072998/real-world-utilization-and-impact-of-the-wearable-cardioverter-defibrillator-in-a-community-setting
#17
Aditi Naniwadekar, Talal Alnabelsi, Kamal Joshi, Edinrin Obasare, Allan Greenspan, Sumeet Mainigi
INTRODUCTION: The wearable cardioverter-defibrillator (WCD) is used in patients at risk for sudden cardiac death (SCD) but not immediate candidates for intracardiac defibrillator (ICD) implantation. METHODS: We performed a single center retrospective study of patients prescribed WCD upon hospital discharge from January 2002 to October 2015. Clinical characteristics were obtained from the hospital electronic database and device data from Zoll LifeVest database. RESULTS: Of 140 patients, 62% were men, 85...
May 2017: Indian Pacing and Electrophysiology Journal
https://www.readbyqxmd.com/read/29071055/gluteal-artery-injuries-including-pseudoaneurysm-associated-with-powered-bone-marrow-biopsies
#18
Aditi P Singh, Gopichand Pendurti, Shashi Singh, Alexander Shestopalov, Thomas Pacello, Louis J Reed
No abstract text is available yet for this article.
September 26, 2017: Hematology Reports
https://www.readbyqxmd.com/read/29066301/wild-type-catalase-peroxidase-vs-g279d-mutant-type-molecular-basis-of-isoniazid-drug-resistance-in-mycobacterium-tuberculosis
#19
Aishwarya Singh, Aditi Singh, Sonam Grover, Bharati Pandey, Anchala Kumari, Abhinav Grover
Mycobacterium tuberculosis katG gene is responsible for production of an enzyme catalase peroxidase that peroxidises and activates the prodrug Isoniazid (INH), a first-line antitubercular agent. INH interacts with catalase peroxidase enzyme within its heme pocket and gets converted to an active form. Mutations occurring in katG gene are often linked to reduced conversion rates for INH. This study is focussed on one such mutation occurring at residue 279, where glycine often mutates to aspartic acid (G279D)...
October 21, 2017: Gene
https://www.readbyqxmd.com/read/29064698/nature-and-hierarchy-of-noncovalent-interactions-in-gas-phase-binary-complexes-of-indole-and-benzimidazole-with-ethers
#20
Aditi Bhattacherjee, Sanjay Wategaonkar
Hierarchy among the weak noncovalent interactions such as van der Waals, electrostatic, hydrogen bonding, etc. dictates the secondary and tertiary structures of proteins as well as their interactions with various ligands. In this work, we investigate the competition between conventional (N-H···O) hydrogen bonds, unconventional (C-H···O) hydrogen bonds, and the van der Waals interaction in the model compounds of the chromophores of the amino acids, tryptophan, and histidine. These include indole (IND), benzimidazole (BIM), and its N-methylated analog (N-methylbenzimidazole, MBIM), which present multiple docking sites...
November 8, 2017: Journal of Physical Chemistry. A
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