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https://www.readbyqxmd.com/read/28533440/identification-and-characterization-of-caenorhabditis-elegans-rnai-inheritance-machinery
#1
George Spracklin, Brandon Fields, Gang Wan, Diveena Vijayendran, Ashley Wallig, Aditi Shukla, Scott Kennedy
Gene silencing mediated by dsRNA (RNAi) can persist for multiple generations in Caenorhabditis elegans (termed RNAi inheritance). Here we describe the results of a forward genetic screen in C. elegans that has identified six factors required for RNAi inheritance: GLH-1/VASA, PUP-1/CDE-1, MORC-1, SET-32, and two novel nematode specific factors that we term here (heritable RNAi defective) HRDE-2 and HRDE-4. The new RNAi inheritance factors exhibit mortal germline (Mrt) phenotypes, which we show is likely caused by epigenetic deregulation in germ cells...
May 22, 2017: Genetics
https://www.readbyqxmd.com/read/28524921/adsorption-of-c2-gases-over-ceo2-based-catalysts-synergism-of-cationic-sites-and-anionic-vacancies
#2
Manjusha C Padole, Bhanu P Gangwar, Aman Pandey, Aditi Singhal, Sudhanshu Sharma, Parag A Deshpande
The synthesis of novel and efficient catalysts for acetylene hydrogenation exhibiting high selectivity towards ethylene is important due to the presence of selective acetylene hydrogenation reaction in petrochemical processing. Since adsorption of C2 gases constitutes the primary step in catalytic hydrogenation and governs the selectivity of the catalysts, we have explored the C2-adsorption potential of reducible CeO2-based systems. The adsorption of C2-gases over CeO2-based materials was assessed using experimental in situ spectroscopic techniques and in silico theoretical studies based on density functional theory...
May 19, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28522687/integrin-linked-kinase-signaling-promotes-cyst-growth-and-fibrosis-in-polycystic-kidney-disease
#3
Archana Raman, Gail A Reif, Yuqiao Dai, Aditi Khanna, Xiaogang Li, Lindsay Astleford, Stephen C Parnell, James P Calvet, Darren P Wallace
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by innumerous fluid-filled cysts and progressive deterioration of renal function. Previously, we showed that periostin, a matricellular protein involved in tissue repair, is markedly overexpressed by cyst epithelial cells. Periostin promotes cell proliferation, cyst growth, interstitial fibrosis, and the decline in renal function in PKD mice. Here, we investigated the regulation of these processes by the integrin-linked kinase (ILK), a scaffold protein that links the extracellular matrix to the actin cytoskeleton and is stimulated by periostin...
May 18, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28520634/associations-between-parental-factors-and-child-diabetes-management-related-behaviors
#4
Aditi Lohan, Alina Morawska, Amy Mitchell
OBJECTIVE: Adherence to diabetes-management regimens in children requires teamwork and consistency from both parents and children. This study investigated a mediational model developed to understand the relationship between different modifiable parent factors influencing child diabetes-related behaviors. METHODS: We recruited 186 parents of children aged 2 to 10 years with Type 1 diabetes to complete self-report questionnaires on child diabetes behavior, parental self-efficacy with managing the child's behavior, parent diabetes self-efficacy, parent adjustment, condition management effort, parent perception of their diabetes knowledge, and parenting behavior...
May 16, 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/28514224/case-246
#5
Aditi Shruti, George S Wu
No abstract text is available yet for this article.
June 2017: Radiology
https://www.readbyqxmd.com/read/28514164/the-non-bulky-dna-lesions-spiroiminodihydantoin-and-5-guanidinohydantoin-significantly-block-human-rna-polymerase-ii-elongation-in-vitro
#6
Marina Kolbanovskiy, Moinuddin A Chowdhury, Aditi Nadkarni, Suse Broyde, Nicholas E Geacintov, David A Scicchitano, Vladimir Shafirovich
The most common, oxidatively generated lesion in cellular DNA is 8-oxo-7,8-dihydroguanine, which can be oxidized further to yield highly mutagenic spiroiminodihydantoin (Sp) and 5-guanidinohydantoin (Gh) in DNA. In human cell-free extracts, both lesions can be excised by base excision repair and global genomic nucleotide excision repair. However, it is not known if these lesions can be removed by transcription-coupled DNA repair (TCR), a pathway that clears lesions from DNA that impede RNA synthesis. To determine if Sp or Gh impede transcription, which could make them viable substrates for TCR, either an Sp or a Gh lesion was positioned on the transcribed strand of DNA under the control of a promoter that supports transcription by human RNA polymerase II...
May 17, 2017: Biochemistry
https://www.readbyqxmd.com/read/28511820/somatic-symptom-disorder-in-dermatology
#7
James L Levenson, Aditi A Sharma, Alex G Ortega-Loayza
Somatic symptom disorder (SSD) is defined by the prominence of somatic symptoms associated with abnormal thoughts, feelings, and behaviors related to the symptoms, resulting in significant distress and impairment. Individuals with these disorders are more commonly encountered in primary care and other medical settings, including dermatology practice, than in psychiatric and other mental health settings. What defines the thoughts, feelings, and behaviors as abnormal is that they are excessive, that is, out of proportion to other patients with similar somatic symptoms, and that they result in significant distress and impairment...
May 2017: Clinics in Dermatology
https://www.readbyqxmd.com/read/28510997/impact-of-m-health-application-used-by-community-health-volunteers-on-improving-utilization-of-maternal-newborn-and-child-health-care-services-in-a-rural-area-of-uttar-pradesh-india
#8
Shankar Prinja, Ruby Nimesh, Aditi Gupta, Pankaj Bahuguna, Madhu Gupta, Jarnail Singh Thakur
OBJECTIVE: To raise the quality of counselling by community health volunteers resulting in improved uptake of maternal, neonatal and child health services (MNCH), an m-health application was introduced under a project named 'Reducing Maternal and Newborn Deaths (ReMiND)' in district Kaushambi in India. We report the impact of this project on coverage of key MNCH services. METHODS: A pre and post quasi-experimental design was undertaken to assess the impact of intervention...
May 16, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28507963/evaluation-of-efficacy-of-three-dimensional-stainless-steel-mini-plates-in-the-treatment-of-fractures-of-the-mandible-a-prospective-study
#9
Shreyas H Gupte, Shruti Chaddva, Yash Jethwani, Aditi Mohandas, Digvijay P Kumavat, Nirali Jhaveri
INTRODUCTION: The purpose of the study was to analyze whether adequate fracture fixation can be achieved by three-dimensional (3D) stainless steel mini-plates its ease of placement, whether the patient can resume function early and to find out the need to do intermaxillary fixation. MATERIALS AND METHODS: In the prospective study, we treated 12 patients and 17 fractured sites using 3D mini-plates. Once fracture reduction was achieved temporary intermaxillary fixation (IMF) was done occlusion was achieved and the fractured segments were fixed using 3D plates either 4-holed or 6-holed of 2...
November 2016: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28505446/role-of-the-c-2-h-hydrogen-bond-donor-in-gas-phase-microsolvation-of-imidazole-derivatives-with-roh-r-ch3-c2h5
#10
Aditi Bhattacherjee, Sanjay Wategaonkar
Although the hydrogen-bonding properties of the protic solvents are comparable, a comparison of the gas-phase structures of water with those of the alcohols reveals certain similarities as well as differences. In this work we report the microsolvated clusters of imidazole derivatives, Benzimidazole (BIM) and N-methylbenzimidazole (MBIM) by methanol (M) and ethanol (E) in supersonic jet using electronic and vibrational spectroscopy and compare them with their hydrated clusters. The cluster sizes up to 1:2 of BIM/MBIM with methanol and ethanol, and up to 1:3 in the case of MBIM-methanol were observed...
May 19, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28502460/can-the-use-of-bone-marrow-parameters-improve-the-efficacy-of-risk-prediction-scores-in-chronic-myeloid-leukemia-in-imatinib-era
#11
Govind Babu Kanakasetty, Aditi Harsh Thanky, Lakshmaiah Kuntegowdanahalli, Lokanatha Dasappa, Linu Jacob, Suresh Babu Mallekavu, Rajeev Lakkavalli, Lokesh Kadabur, Rudresha Antapura
INTRODUCTION: Many attempts have been made to develop risk prediction scores for chronic myeloid leukemia in chronic phase (CML-CP) to identify the subgroup with a poorer response to therapy to enable early intensification of treatment. Because the bone marrow (BM) provides a more sensitive reflection of the disease process, we hypothesized that using BM parameters in the Sokal and European Treatment and Outcome Study (EUTOS) risk scores could improve their efficacy in an imatinib-treated population...
March 30, 2017: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/28499360/prevalence-and-correlates-of-cognitive-impairment-in-kidney-transplant-recipients
#12
Aditi Gupta, Jonathan D Mahnken, David K Johnson, Tashra S Thomas, Dipti Subramaniam, Tyler Polshak, Imran Gani, G John Chen, Jeffrey M Burns, Mark J Sarnak
BACKGROUND: There is a high prevalence of cognitive impairment in dialysis patients. The prevalence of cognitive impairment after kidney transplantation is unknown. METHODS: Study Design: Cross-sectional study. SETTING AND PARTICIPANTS: Single center study of prevalent kidney transplant recipients from a transplant clinic in a large academic center. INTERVENTION: Assessment of cognition using the Montreal Cognitive Assessment (MoCA)...
May 12, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28485504/mechanistic-principles-behind-molecular-mechanism-of-rifampicin-resistance-in-mutant-rna-polymerase-beta-subunit-of-mycobacterium-tuberculosis
#13
Aditi Singh, Sonam Grover, Sidhartha Sinha, Mriganko Das, Pallavi Somvanshi, Abhinav Grover
Evolution of drug resistant Mycobacterium strains threatens the TB treatment and control programs globally. Rifampicin (RIF) is an important first line antitubercular drug. Resistance to Rifampicin is caused mainly by mutations in its target RNA polymerase beta subunit protein (RpoB). RpoB contains a Rifampicin resistance determining region (RRDR) and has several potent sites for mutations. In this study, we have investigated mutations of a single site (H451) to eight different amino acids, involved in RIF resistance...
May 9, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28483078/clinical-course-and-treatment-outcome-of-koro-a-follow-up-study-from-a-koro-epidemic-reported-from-west-bengal-india
#14
Amitava Dan, Tanushree Mondal, Kaustav Chakraborty, Aditi Chaudhuri, Asish Biswas
BACKGROUND: Koro, as a culture bound syndrome is predominantly reported from Asian countries. There is dearth of well-designed research focussing on course and outcome of Koro. METHOD: In the index study, 64 consecutive consenting patients with symptoms of Koro reported in different disciplines of a tertiary care Government Hospital of West Bengal were recruited over a period of 3 months. They were treated by standard treatment protocol and followed up for next 3 months...
April 2017: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/28478717/selexipag-an-oral-prostacyclin-receptor-agonist-for-pulmonary-arterial-hypertension
#15
William L Baker, Konstadina Darsaklis, Aditi Singhvi, Edward L Salerno
OBJECTIVE: To evaluate the data supporting the approval of selexipag and discuss its potential place in therapy for managing pulmonary arterial hypertension (PAH). DATA SOURCES: A systematic review of the literature for all relevant articles was performed through January 16, 2017, using MEDLINE and SCOPUS. A manual search of references from reports of clinical trials, review articles, and recent conference abstracts was performed to identify additional relevant studies...
June 2017: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/28476594/studying-in-vitro-phagocytosis-of-apoptotic-cancer-cells-by-recombinant-gmcsf-treated-raw-264-7-macrophages
#16
Vanitha Selvarajan, Anil Parsram Bidkar, Rajib Shome, Aditi Banerjee, Nidhi Chaubey, Siddhartha S Ghosh, Pallab Sanpui
Granulocyte macrophage colony stimulating factor (GMCSF), a therapeutically important cytokine that helps in the proliferation of macrophages, was recombinantly expressed in E. coli BL21 and purified as a GST-tagged protein. Cell viability assay demonstrated significant enhancement in proliferation of RAW 264.7 (murine macrophage) in presence of GMCSF. In vitro activation of macrophages was carried out by lipopolysaccharide (LPS) or pyrogallol and probed by the generation of reactive oxygen species (ROS). Following the induction of apoptosis in A549 lung cancer cells with anticancer drug cisplatin (at 25μM), apoptotic cancer cells were effectively phagocytosed by the recombinant GMCSF-treated and exogenously activated RAW 264...
May 2, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28474213/growth-and-biochemical-characteristics-of-an-indigenous-freshwater-microalga-scenedesmus-obtusus-cultivated-in-an-airlift-photobioreactor-effect-of-reactor-hydrodynamics-light-intensity-and-photoperiod
#17
T Sarat Chandra, S Aditi, M Maneesh Kumar, S Mukherji, J Modak, V S Chauhan, R Sarada, S N Mudliar
The freshwater green algae, Scenedesmus obtusus, was cultivated in a 3.4 L airlift photobioreactor. The hydrodynamic parameters were estimated at different inlet gas flow rates (1, 2, 3, and 4 LPM) and their subsequent impact on the growth and biochemical characteristics of microalgae was studied. The biomass concentration and productivity increased with an increase in flow rates from 1 to 4 LPM. A maximum of 0.07 g L(-1) day(-1) productivity of biomass was attained at 3 LPM. An increase of total carbohydrate content from 19...
May 4, 2017: Bioprocess and Biosystems Engineering
https://www.readbyqxmd.com/read/28467931/activation-of-skeletal-muscle-ampk-promotes-glucose-disposal-and-glucose-lowering-in-non-human-primates-and-mice
#18
Emily C Cokorinos, Jake Delmore, Allan R Reyes, Bina Albuquerque, Rasmus Kjøbsted, Nicolas O Jørgensen, Jean-Luc Tran, Aditi Jatkar, Katherine Cialdea, Ryan M Esquejo, John Meissen, Matthew F Calabrese, Jason Cordes, Robert Moccia, David Tess, Christopher T Salatto, Timothy M Coskran, Alan C Opsahl, Declan Flynn, Matthew Blatnik, Wenlin Li, Erick Kindt, Marc Foretz, Benoit Viollet, Jessica Ward, Ravi G Kurumbail, Amit S Kalgutkar, Jørgen F P Wojtaszewski, Kimberly O Cameron, Russell A Miller
The AMP-activated protein kinase (AMPK) is a potential therapeutic target for metabolic diseases based on its reported actions in the liver and skeletal muscle. We evaluated two distinct direct activators of AMPK: a non-selective activator of all AMPK complexes, PF-739, and an activator selective for AMPK β1-containing complexes, PF-249. In cells and animals, both compounds were effective at activating AMPK in hepatocytes, but only PF-739 was capable of activating AMPK in skeletal muscle. In diabetic mice, PF-739, but not PF-249, caused a rapid lowering of plasma glucose levels that was diminished in the absence of skeletal muscle, but not liver, AMPK heterotrimers and was the result of an increase in systemic glucose disposal with no impact on hepatic glucose production...
May 2, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/28464702/pavlov-s-orienting-response-in-frontotemporal-dementia
#19
Aditi Joshi, Elvira Jimenez, Mario F Mendez
Behavior variant frontotemporal dementia (bvFTD) is a neurodegenerative disorder with initial disturbances in socioemotional behavior in the absence of a sensitive diagnostic test. This study evaluated Pavlov's "orienting response" (OR) or "what is it?" reflex as a measure of their ability to refocus attention on socioemotional stimuli and as a potentially distinguishing measure for bvFTD. Ten patients with bvFTD were compared with 18 normal controls (NC) on ORs (defined as initial heart rate [HR] deceleration) to different pictures based on social and emotional (valence) differences from the International Affective Picture Stimuli...
May 3, 2017: Journal of Neuropsychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28461067/mapping-information-exposure-on-social-media-to-explain-differences-in-hpv-vaccine-coverage-in-the-united-states
#20
Adam G Dunn, Didi Surian, Julie Leask, Aditi Dey, Kenneth D Mandl, Enrico Coiera
BACKGROUND: Together with access, acceptance of vaccines affects human papillomavirus (HPV) vaccine coverage, yet little is known about media's role. Our aim was to determine whether measures of information exposure derived from Twitter could be used to explain differences in coverage in the United States. METHODS: We conducted an analysis of exposure to information about HPV vaccines on Twitter, derived from 273.8 million exposures to 258,418 tweets posted between 1 October 2013 and 30 October 2015...
April 28, 2017: Vaccine
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