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mycosis fungoides.

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https://www.readbyqxmd.com/read/28711574/bath-psoralen-ultraviolet-a-and-narrowband-ultraviolet-b-phototherapy-as-initial-therapy-for-early-stage-mycosis-fungoides-a-retrospective-cohort-of-267-cases-at-the-university-of-toronto
#1
Mohammad Almohideb, Sandra Walsh, Scott Walsh, Neil Shear, Raed Alhusayen
BACKGROUND: Phototherapy is used frequently to treat early-stage mycosis fungoides (MF). The effectiveness of bath psoralen-ultraviolet A (bath PUVA) and narrowband ultraviolet B (nbUVB) in MF is well established. However, evidence is limited comparing the effectiveness of the 2 modalities for early-stage MF. The objective of the present study was to compare the responses between the study participants receiving bath PUVA versus nbUVB phototherapy. PATIENTS AND METHODS: The study included a retrospective cohort of stage 1A and 1B MF patients treated with bath PUVA or nbUVB at their initial presentation...
June 19, 2017: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/28709694/early-clinical-manifestations-of-s%C3%A3-zary-syndrome-a-multicenter-retrospective-cohort-study
#2
Aaron R Mangold, Agnieszka K Thompson, Mark D Davis, Ieva Saulite, Antonio Cozzio, Emmanuella Guenova, Emmilia Hodak, Iris Amitay-Laish, Ramon M Pujol, Mark R Pittelkow, Robert Gniadecki
BACKGROUND: Classic Sézary syndrome (SS) is defined by erythroderma, generalized lymphadenopathy, and leukemic blood involvement. Clinical observations suggest that SS begins as a nonerythrodermic disease. OBJECTIVE: To describe the early clinical characteristics of patients with SS. METHODS: A retrospective, multicenter chart review was performed for 263 confirmed cases of SS diagnosed during 1976-2015. RESULTS: Erythroderma was the earliest recorded skin sign of SS in only 25...
July 11, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28702497/mycosis-fungoides-presenting-as-symmetric-concentric-patches-mimicking-figurate-erythema
#3
Manisha Notay, Tatyana A Petukhova, Maija Kiuru, Christian A Kunder, Samuel T Hwang
No abstract text is available yet for this article.
July 2017: JAAD Case Reports
https://www.readbyqxmd.com/read/28692463/syringotropic-mycosis-fungoides-a-rare-form-of-cutaneous-t-cell-lymphoma-enabling-a-histopathologic-sigh-of-relief
#4
Larisa M Lehmer, Kyle T Amber, Sébastien M de Feraudy
Syringotropic mycosis fungoides (STMF) is a very rare variant of cutaneous T-cell lymphoma. It follows a much milder disease course than its clinically indistinguishable adnexal counterpart, folliculotropic mycosis fungoides (FMF). We report a case of a 36-year-old man who presented with erythematous, studded papules and plaques on the left upper extremity and right anterior thigh diagnosed as mycosis fungoides (MF) Stage 1A on initial superficial shave biopsy. Lesions recurred after initial improvement with narrow-band ultraviolet light therapy demonstrating a concentration of abnormal lymphocytes around eccrine sweat glands on repeat biopsy consistent with STMF...
May 18, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28690516/eruptive-seborrheic-keratoses-restricted-to-plaque-patch-stage-mycosis-fungoides
#5
Eve Lebas, Pascale Quatresooz, Jorge E Arrese, Arjen F Nikkels
Eruptive seborrheic keratoses (ESK) are rare in dermatology. They are usually inflammatory in nature and may be encountered as Leser-Trélat sign. ESK may also be simultaneously observed with hepatic angiomas, chemotherapy, segmental neurofibromatosis, HIV or erythrodermic pityriasis rubra pilaris, psoriasis, and drug eruption. ESK may be transient and self-healing. Others recede after successful treatment of the underlying disease. In some instances, seborrheic keratoses may follow an isotopic response and remain strictly restricted to sites of previous eczema, photo-exposition or tattoos...
May 2017: Case Reports in Dermatology
https://www.readbyqxmd.com/read/28676328/cd8-mycosis-fungoides-a-low-grade-lymphoproliferative-disorder
#6
Maria Estela Martinez-Escala, Robert W Kantor, Ahuva Cices, Xiaolong A Zhou, Jason B Kaplan, Barbara Pro, Jaehyuk Choi, Joan Guitart
BACKGROUND: The prognosis of the CD8(+) subtype of mycosis fungoides (MF) is controversial. Although most authors believe that determining the presence of this cell surface antigen has no prognostic value, others have observed a more indolent course for CD8(+) MF compared with CD4(+) MF. OBJECTIVES: To review the cases of CD8(+) MF in the pediatric and adult populations seen at our institution. METHODS: This is a retrospective review of clinical and pathologic data...
July 1, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28670259/langerhans-cell-histiocytosis-followed-by-folliculotropic-mycosis-fungoides
#7
Izabela Błażewicz, Małgorzata Sokołowska-Wojdyło, Agnieszka Piekarska, Alicja Sadowska-Klasa, Anna Kowalczyk, Monika Konczalska, Berenika Olszewska, Wioletta Barańska-Rybak, Wojciech Biernat, Roman J Nowicki
No abstract text is available yet for this article.
June 2017: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/28655598/annual-facility-treatment-volume-and-patient-survival-for-mycosis-fungoides-and-s%C3%A3-zary-syndrome
#8
Benjamin H Kann, Henry S Park, Debra N Yeboa, Sanjay Aneja, Michael Girardi, Francine M Foss, Kenneth B Roberts, Lynn D Wilson
BACKGROUND: Management of mycosis fungoides and Sézary syndrome (MF/SS) is complex, and randomized evidence to guide treatment is lacking. The institutional treatment volumes for MF/SS might vary widely nationally and influence patient survival. PATIENTS AND METHODS: Using the National Cancer Database, we identified patients with a diagnosis of MF/SS from 2004 to 2011 in the United States who had received treatment at a reporting facility. The patients were grouped into quintiles according to their treatment facility's average annual treatment volume (ATV)...
June 24, 2017: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/28654469/the-histopathological-spectrum-of-pseudolymphomatous-infiltrates-in-cutaneous-lupus-erythematosus
#9
Amanda Pereira, Gerardo Ferrara, Paola Calamaro, Carlo Cota, Cesare Massone, Francesca Boggio, Lucia Prieto-Torres, Lorenzo Cerroni
The occurrence of pseudolymphomatous infiltrates in cutaneous lupus erythematosus (cLE) is described mainly in lupus panniculitis and lupus tumidus/lymphocytic infiltration of the skin (Jessner-Kanof). We collected 15 cases of pseudolymphomatous cLE other than lupus panniculitis and lupus tumidus (M:F = 4:11; age range: 23-79 years; mean age: 50.9 years; median age: 57 years). Of the 15 cases, 9 (60%) were characterized by dense nodular infiltrates. Three cases (20%) showed an angiocentric pattern with cytological atypia of lymphoid cells; 2 cases (13...
June 20, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28654464/lichenoid-granulomatous-mycosis-fungoides
#10
Maria Concepción Garrido, Lidia Maroñas-Jimenez, Pablo Luis Ortiz, Jose Luis Rodriguez-Peralto
The presence of a granulomatous reaction in cutaneous lymphomas has been described in the past, especially in mycosis fungoides (MF), where a "granulomatous" variant of the disease is well known. We describe a patient with granulomatous MF (GMF) who has been followed for 13 years presenting with erythematosquamous plaques on his fingers and toes, ankles, heels, and abdomen, which on microscopic examination showed a lichenoid granulomatous reaction admixed with a neoplastic proliferation of small-sized, atypical CD4 lymphocytes...
August 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28653029/an-adolescent-with-granulomatous-mycosis-fungoides-infiltrating-skeletal-muscle-successfully-treated-with-oral-prednisone
#11
Daniel J Lewis, Ashley E Turkeltaub, Julia Dai, Priyadharsini Nagarajan, Kerri E Rieger, Cesar A Nunez, Youn H Kim, Madeleine Duvic
No abstract text is available yet for this article.
July 2017: JAAD Case Reports
https://www.readbyqxmd.com/read/28648940/upregulation-of-inhibitory-signaling-receptor-programmed-death-marker-1-pd-1-in-disease-evolution-from-cutaneous-lymphoid-dyscrasias-to-mycosis-fungoides-and-sezary-s-syndrome
#12
Giang Huong Nguyen, Luke C Olson, Cynthia M Magro
BACKGROUND: Negative immunoregulatory checkpoints impede effective immune responses to tumor and reduce the action of anticancer agents. One such example is programmed death marker-1 (PD-1), an inhibitory signaling receptor expressed on activated and regulatory T-cells. PD-1 expression was reported in a few reports, but the expression profile of PD-1 and mycosis fungoides (MF) remains largely to be characterized. DESIGN: In this study, skin biopsies from 42 prelymphomatous T-cell dyscrasias (CLD), 9 Sezary's syndrome (SS), 103 MF, and 20 CD30+ lymphoproliferative diseases (LPD) were examined for PD-1 expression using immunohistochemistry...
June 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/28648516/-mycosis-fungoides-in-a-heart-transplant-recipient
#13
Q Bodard, N Litrowski, D Carre, M Midhat, P Chenal, P Bravard
BACKGROUND: Skin cancer occurs frequently in organ transplant patients as a result of induced immunosuppression. Most cases involve carcinomas or B-cell lymphomas induced by the Epstein Barr virus (EBV). Cutaneous T-cell lymphomas remain rare. We report a case of cutaneous T-cell lymphoma of the mycosis fungoides type in a heart transplant recipient. PATIENTS AND METHODS: A 68-year-old man who had received a heart transplant 21years earlier and was being treated with tacrolimus, mycophenolate mofetil and prednisolone had been presenting a psoriasiform rash on his trunk, limbs and head for 4years...
June 22, 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/28645647/racial-disparity-in-mycosis-fungoides-an-analysis-of-4495-cases-from-the-us-national-cancer-database
#14
Chang Su, Kevin A Nguyen, Harrison X Bai, Ya Cao, Yongguang Tao, Rong Xiao, Giorgos Karakousis, Paul J Zhang, Guiying Zhang
BACKGROUND: Studies have shown contradictory results regarding the survival outcomes among white, African American, and Asian patients with mycosis fungoides (MF). OBJECTIVE: To evaluate the survival outcomes among white, African American, and Asian patients with MF and to determine other prognostic factors of the disease. METHODS: The US National Cancer Database was used to identify patients with histologically confirmed MF from 2004 to 2014...
June 20, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28635518/complete-resolution-of-mycosis-fungoides-tumors-with-imiquimod-5-cream-a-case-series
#15
Daniel J Lewis, Yevgeniya A Byekova, Drew A Emge, Madeleine Duvic
OBJECTIVE: To demonstrate the clinical efficacy of topical 5% imiquimod for mycosis fungoides (MF) tumors. BACKGROUND: Treatment of tumor-stage MF represents a therapeutic challenge because of a limited number of effective topical therapies. Single tumors can be treated with localized radiation but may recur. Systemic therapies are also an option but are associated with serious adverse effects. Imiquimod is a topical agent whose efficacy has been documented in treating MF patches and plaques as well as one case of tumor-stage disease...
March 2, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28631636/profiling-of-peripheral-t-cell-lymphomas-in-kerala-south-india-a-5-year-study
#16
Rekha A Nair, Jayasudha Arundhathi Vasudevan, Priya Mary Jacob, Renu Sukumaran
BACKGROUND: Peripheral T-cell lymphomas (PTCLs) are non-Hodgkin's lymphomas (NHLs) with considerable variation in incidence across the world. They show a wide variety of clinicopathological features and generally associated with poor clinical outcome. Lymphoma data from different geographic regions will definitely aid in routine clinical practice and research work. PTCLs are reported with a higher frequency in Asia as compared to Western countries. OBJECTIVE: The objective of this study was to analyze the frequency and distribution of PTCLs diagnosed in a tertiary care cancer center in Kerala...
April 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/28624795/tissue-and-serum-lipidome-shows-altered-lipid-composition-with-diagnostic-potential-in-mycosis-fungoides
#17
Chenchen Xu, Dan Zhou, Yixin Luo, Shuai Guo, Tao Wang, Jie Liu, Yuehua Liu, Zhili Li
Mycosis fungoides (MF) is the most common type of cutaneous T cell lymphoma. In this study, we used matrix-assisted laser desorption/ionization-Fourier transform ion cyclotron resonance mass spectrometry (MALDI-FTICR-MS) to perform lipidomic profiling of 5 MF tissue samples and 44 serum samples (22 from MF patients and 22 from control subjects). Multivariate statistical analysis of the mass spectral data showed that MF tissues had altered levels of seven lipids and MF sera had altered levels of twelve. Among these, six phosphotidylcholines, PC (34:2), PC (34:1), PC (36:3), PC (36:2), PC (32:0), and PC (38:4) and one sphingomyelin, SM (16:0) were altered in both MF tissues and sera...
May 26, 2017: Oncotarget
https://www.readbyqxmd.com/read/28614957/associated-hematolymphoid-malignancies-in-patients-with-lymphomatoid-papulosis-a-canadian-retrospective-study
#18
Mohanad AbuHilal, Scott Walsh, Neil Shear
BACKGROUND: Lymphomatoid papulosis is one of the primary cutaneous CD30+ T-cell lymphoproliferative disorders. Although considered a benign disease, lymphomatoid papulosis has been associated potentially with an increased risk of secondary hematolymphoid malignancies. OBJECTIVE: The aim of this study was to assess the clinical characteristics and histologic subtypes of lymphomatoid papulosis, identify the prevalence and types of secondary hematolymphoid malignancies, and determine the potential risk factors for development of these hematolymphoid malignancies...
June 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28600132/brentuximab-vedotin-or-physician-s-choice-in-cd30-positive-cutaneous-t-cell-lymphoma-alcanza-an-international-open-label-randomised-phase-3-multicentre-trial
#19
H Miles Prince, Youn H Kim, Steven M Horwitz, Reinhard Dummer, Julia Scarisbrick, Pietro Quaglino, Pier Luigi Zinzani, Pascal Wolter, Jose A Sanches, Pablo L Ortiz-Romero, Oleg E Akilov, Larisa Geskin, Judith Trotman, Kerry Taylor, Stephane Dalle, Michael Weichenthal, Jan Walewski, David Fisher, Brigitte Dréno, Rudolf Stadler, Tatyana Feldman, Timothy M Kuzel, Yinghui Wang, Maria Corinna Palanca-Wessels, Erin Zagadailov, William L Trepicchio, Wenwen Zhang, Hui-Min Lin, Yi Liu, Dirk Huebner, Meredith Little, Sean Whittaker, Madeleine Duvic
BACKGROUND: Cutaneous T-cell lymphomas are rare, generally incurable, and associated with reduced quality of life. Present systemic therapies rarely provide reliable and durable responses. We aimed to assess efficacy and safety of brentuximab vedotin versus conventional therapy for previously treated patients with CD30-positive cutaneous T-cell lymphomas. METHODS: In this international, open-label, randomised, phase 3, multicentre trial, we enrolled adult patients with CD30-positive mycosis fungoides or primary cutaneous anaplastic large-cell lymphoma who had been previously treated...
June 6, 2017: Lancet
https://www.readbyqxmd.com/read/28597017/folliculotropic-mycosis-fungoides-with-skewed-t-cell-receptor-cdr3-motif-suggestive-of-lipid-antigen-selection
#20
Panagiota Mantaka, Agnieszka Malecka, Gunhild Trøen, Per Helsing, Petter Gjersvik, Klaus Beiske, Jan Delabie
Folliculotropic mycosis fungoides (FMF), a variant of mycosis fungoides (MF) with distinct clinical features, is characterized by infiltration of malignant T cells in hair follicles. This raises the hypothesis that antigens in the hair follicle may contribute to the pathogenesis of FMF. T-cell receptor β gene (TRB) sequences as well as dendritic cell subsets in patients with FMF (n = 21) and control patients with MF (n = 20) were studied to explore this hypothesis. A recurrent usage of the TRB junctional genes TRBJ2-1 and TRBJ2-7 was found in patients with FMF compared with those with MF...
June 9, 2017: Acta Dermato-venereologica
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