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mycosis fungoides.

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https://www.readbyqxmd.com/read/29449683/adult-t-cell-leukemia-lymphoma-can-be-indistinguishable-from-other-more-common-t-cell-lymphomas-the-university-of-miami-experience-with-a-large-cohort-of-cases
#1
Mahsa Khanlari, Juan Carlos Ramos, Sandra Patricia Sanchez, Jeong Hee Cho-Vega, Alexandra Amador, German Campuzano-Zuluaga, Francisco Vega, Jennifer R Chapman
Adult T-cell leukemia/lymphoma, an aggressive T-cell neoplasm, is causally linked to human T-cell lymphotropic virus type 1 and based on this association has a distinct geographic distribution. In our United States-based practice, whose population is enriched for immigrants from human T-cell lymphotropic virus type 1 endemic areas, we have identified that a subset of adult T-cell leukemia/lymphoma, in the absence of human T-cell lymphotropic virus type 1 identification, are indistinguishable from other more common T-cell neoplasms...
February 15, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29445460/case-report-photo-onycholysis-after-puva-treatment-for-hypopigmented-mycosis-fungoides-with-response-to-topical-steroid
#2
Paul Jie Wen Tern, Julia Gass
Melanin in the nail bed in patients with skin type VI has been suggested to afford some protection against photo-onycholysis. We report a case of a 16-year-old male patient with skin type VI with onycholysis following PUVA treatment for hypopigmented mycosis fungoides. Symptoms resolved with the application of topical steroid.
February 2018: Clinical Case Reports
https://www.readbyqxmd.com/read/29440874/clinical-potential-of-mechlorethamine-gel-for-the-topical-treatment-of-mycosis-fungoides-type-cutaneous-t-cell-lymphoma-a-review-on-current-efficacy-and-safety-data
#3
REVIEW
Kendall Liner, Celeste Brown, Laura Y McGirt
Nitrogen mustard is a chemotherapeutic agent that has a well-documented safety and efficacy profile in the treatment of cutaneous T-cell lymphoma. Development of nitrogen mustard formulations and treatment regimens has been studied extensively over the last 40 years. In the last 5 years, a new gel formulation has been developed that is associated with a decrease in delayed hypersensitivity reactions. The authors in this review found that while the gel formulation may result in a decrease of allergic contact dermatitis, this advantage has been replaced by a higher number of irritant contact reactions and a decrease in complete response rate...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29437735/successful-treatment-of-extensive-splanchnic-vein-thrombosis-in-a-patient-with-mycosis-fungoides
#4
Nishtha Sanjay Nagral, Vijay Waman Dhakre, Nirzar Parikh, Shaji Marar
A 33-year-old man of a Middle Eastern origin presented to us with abdominal pain and distension secondary to refractory ascites of 1-month duration. The patient had a history of taking oral retinoic acid 25 mg for 4 months for mycosis fungoides. Investigations revealed thrombosis of hepatic veins with extensive thrombosis of the porto-mesenteric axis. A combination of transjugular intrahepatic portosystemic shunt, balloon angioplasty and thrombolysis with recombinant tissue plasminogen activator was successfully used to treat his condition...
February 5, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29417797/verrucous-mycosis-fungoides
#5
Michelangelo LA Placa, Aurora Alessandrini, Claudio Agostinelli, Alessandro Pileri
No abstract text is available yet for this article.
February 7, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29405482/molecular-genetic-analyses-of-human-endogenous-retroviral-elements-belonging-to-the-herv-p-and-r-family-in-primary-cutaneous-t-cell-lymphomas
#6
Massimiliano Bergallo, Paolo Fava, Ilaria Galliano, Mauro Novelli, Paola Montanari, Valentina Daprà, Marco Rassu, Pietro Quaglino, Maria Teresa Fierro
Mycosis fungoides (MF) is characterized by longstanding, scaly patch lesions preferentially involving the buttocks and body areas infrequently exposed to sunlight and by a slow evolution over years from patches to plaques and eventually tumors or erythroderma. Lymph node and visceral involvement, as well as large cell transformation, frequently occur in the late stages of the disease [1]. Sézary syndrome (SS) is an erythrodermic cutaneous T-cell lymphoma (CTCL) with leukemic involvement, an aggressive clinical behavior and poor prognosis [2]...
February 6, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29386841/hypopigmented-mycosis-fungoides-treated-with-308-nm-excimer-laser
#7
Min-Young Yang, Hyunju Jin, Hyang-Suk You, Woo-Haing Shim, Jeong-Min Kim, Gun-Wook Kim, Hoon-Soo Kim, Hyun-Chang Ko, Byung-Soo Kim, Moon-Bum Kim
No abstract text is available yet for this article.
February 2018: Annals of Dermatology
https://www.readbyqxmd.com/read/29381224/the-pathological-spectrum-and-clinical-correlation-of-pigmented-purpuric-dermatosis-a-retrospective-review-of-107-cases
#8
Yen-Kai Huang, Cheng-Kuan Lin, Yu-Hung Wu
BACKGROUND: Various pathological findings have been reported in pigmented purpuric dermatosis, but their clinical significance remains unclear. METHODS: We retrospectively reviewed demographics, clinical presentations, pathological patterns, and concurrent systemic diseases among biopsy-confirmed cases of pigmented purpuric dermatosis. RESULTS: A total of 107 cases were ascertained. Five major pathological patterns were identified: lichenoid (45/107, 42...
January 30, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29378678/type-d-cd8-lymphomatoid-papulosis-in-a-patient-with-classic-cd4-mycosis-fungoides
#9
Junko Hori-Kosogabe, Toshihisa Hamada, Shin Morizane, Yoji Hirai, Tomoko Miyake, Tadashi Yoshino, Keiji Iwatsuki
No abstract text is available yet for this article.
January 29, 2018: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/29368862/clinical-and-histological-evaluation-in-patients-with-mycosis-fungoides-treated-with-uva1
#10
Emanuele Trovato, Michele Pellegrino, Federica Filippi, Virginia Mancini, Nicola Pimpinelli, Michele Fimiani
BACKGROUND: UVA1 phototherapy is a valid therapeutic alternative for skin lymphoproliferative disorders, although there are few studies concerning its role in mycosis fungoides (MF). Our aim was to evaluate and confirm the effectiveness of UVA1 phototherapy in patients in early stage Mycosis Fungoides (MF). METHODS: We enrolled 12 patients, 9 males and 3 females (mean age 54.83 ± 9.99, range 36-74) with a histological diagnosis of mycosis fungoides at early stage...
January 24, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29361381/drug-induced-pseudolymphoma
#11
REVIEW
Cynthia M Magro, Brianne H Daniels, A Neil Crowson
Atypical lymphocytic infiltrates of the skin comprise a broad spectrum of entities ranging from benign infiltrates to those that are malignant. Many of these infiltrates are in fact reactive lymphomatoid ones related to drug therapy falling under the general category of drug associated pseudolymphoma. Within this nosologic umbrella are nodular and diffuse infiltrates resembling low grade T and B cell lymphoma consistent with lymphocytoma cutis, drug associated reversible T cell dyscrasias which draw a strong morphologic and phenotypic parallel with mycosis fungoides and the various pre-lymphomatous T cell dyscrasias, and angiocentric CD30 positive infiltrates mirroring lymphomatoid papulosis...
January 17, 2018: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/29356170/t-cell-papulosis-associated-with-b-cell-malignancy-a-distinctive-clinicopathologic-entity
#12
L V Visseaux, A D Durlach, S B Barete, M B B Beylot-Barry, N B Bonnet, A F C Chassine, N F Franck, G H Herve, C L Leclec'h, L M Machet, S I O Ingen-Housz-Oro, T P Petrella, B V Vergier, N O Ortonne, F G Grange
BACKGROUND: A distinctive eruption referred to as "insect bite-like reaction", or "eosinophilic dermatosis of hematologic malignancy" has been described during the course of hematological B-cell malignancies (BCM). However, its clinical evolution, histopathological features and pathogenesis remain unclear. OBJECTIVES: To characterize this eruption and to investigate its pathogenesis and relationship with the underlying BCM. METHODS: In this multicenter retrospective study of the French Study Group on Cutaneous Lymphomas, 37 patients with a BCM and a cutaneous eruption consisting in chronic and/or recurrent papules, papulo-vesicles and/or nodules were included...
January 22, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29341283/mogamulizumab-induced-photosensitivity-in-patients-with-mycosis-fungoides-and-other-t-cell-neoplasms
#13
Y Masuda, K Tatsuno, S Kitano, H Miyazawa, J Ishibe, M Aoshima, T Shimauchi, T Fujiyama, T Ito, Y Tokura
BACKGROUND: Mogamulizumab (Mog) is a defucosylated, therapeutic monoclonal antibody, targeting CCR4 and was first approved in Japan for the treatment of adult T-cell leukaemia/lymphoma (ATLL), followed by cutaneous T-cell lymphoma and peripheral T-cell lymphoma. OBJECTIVE: To retrospectively investigate development of photosensitivity in patients with mycosis fungoides and other T-cell neoplasms after treatment with Mog. METHODS: We treated seven cutaneous lymphoma patients with Mog...
January 16, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29336316/mycosis-fungoides-in-patients-with-psoriasis-an-ongoing-issue
#14
Despoina Papathemeli, Elisavet Georgiou, Triantafyllia Koletsa, Dimitrios Sotiriadis, Aikaterini Patsatsi
No abstract text is available yet for this article.
January 16, 2018: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/29327377/s%C3%A3-zary-syndrome-managed-with-histone-deacetylase-inhibitor-followed-by-anti-ccr4-monoclonal-antibody
#15
T Numata, T Nagatani, K Shirai, T Maeda, K Mae, M Nakasu, M Saito, T Usuda, R Tsuboi, Y Okubo
A 70-year-old man presented to our clinic with a 10-year history of recurrent pruritic erythema and plaques on his trunk and limbs. Based on the pathological findings and monoclonal rearrangement of the T-cell receptor (TCR)-Cβ1 gene, mycosis fungoides (T2N0M0B0 stage IB) was diagnosed. Despite combination therapy including histone deacetylase inhibitor (vorinostat), the symptoms slowly evolved into Sézary syndrome (SS; T4N1M0B2) over 4 years, with dense infiltrates due to atypical lymphocytes expressing CCR4 developing in the entire dermis...
January 12, 2018: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/29321428/synchronous-occurrence-of-mycosis-fungoides-diffuse-large-b-cell-lymphoma-and-acute-myeloid-leukemia-a-report-of-two-cases
#16
Junichi Miyatake, Hiroaki Inoue, Kentarou Serizawa, Yasuyoshi Morita, J L Espinoza, Hirokazu Tanaka, Takahiro Shimada, Yoichi Tatsumi, Takashi Ashida, Itaru Matsumura
Patients with mycosis fungoides (MF), the most common subtype of primary cutaneous T-cell lymphoma, have an increased risk of developing secondary malignancies. We herein report two rare cases of MF concurring with diffuse large B cell lymphoma (B lymphoid lineage) and acute myeloid leukemia (myeloid lineage) in two otherwise healthy elderly patients. Potential etiologic factors, including the impact of the therapy-associated inflammatory response on the development of secondary tumors in patients with MF, are discussed...
January 11, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29318909/how-to-discern-folliculotropic-mycosis-fungoides-from-follicular-mucinosis-using-a-pediatric-case
#17
Drew A Emge, Daniel J Lewis, Phyu P Aung, Madeleine Duvic
Folliculotropic mycosis fungoides (FMF) is a variant of mycosis fungoides (MF) with folliculotropic, atypical lymphocytes that may or may not have mucin deposition surrounding the hair follicle. Follicular mucinosis (FM) is a primary or secondary finding in FMF, lupus, or collagen vascular diseases that is only a histological process of mucin deposition surrounding the hair follicles. We present a case of a 6-year-old boy who had features of both FMF and primary follicular mucinosis (PFM). The case reveals key insights on FMF with concurrent FM in pediatric patients and how to differentiate between FMF and PFM...
January 1, 2018: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29318586/hypopigmented-mycosis-fungoides-a-20-case-retrospective-series
#18
Gustavo M Amorim, Joao P Niemeyer-Corbellini, Danielle C Quintella, Tullia Cuzzi, Marcia Ramos-E-Silva
BACKGROUND: Hypopigmented mycosis fungoides (hMF) is a rare subtype of mycosis fungoides. The aim of this study was to identify the clinical-epidemiological profile of our patient group and also to provide additional information about treatment responses and prognosis. METHODS: This is a cross-sectional retrospective observational study, with exploratory analysis. The outcome variables were disease progression and related death. RESULTS: Twenty patients with hMF were selected from a group of 102 patients diagnosed with MF...
January 10, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29318585/dermoscopic-characterization-of-cutaneous-lymphomas-a-pilot-survey
#19
Grant K Ghahramani, Kirsten E Goetz, Vincent Liu
BACKGROUND: While substantial dermoscopic analysis of melanocytic lesions has been performed, dermoscopic characterization of cutaneous lymphoid proliferations has been limited. Cutaneous lymphoma, particularly early mycosis fungoides (MF) and its variants, is often challenging to clinically and pathologically distinguish from inflammatory processes of the skin. This study aimed to survey the dermoscopic findings of cutaneous lymphomas and to discern whether any patterns might potentially serve as specific signatures...
January 10, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29316111/etoposide-as-a-single-agent-in-the-treatment-of-mycosis-fungoides-a-retrospective-analysis
#20
Seda Purnak, Jose Azar, Lawrence Aaron Mark
Several chemotherapy agents have shown efficacy in the treatment of mycosis fungoides (MF). In the literature, there is limited data on the use of single agent etoposide for MF. We aimed to retrospectively review our experience with single agent etoposide in the treatment of advanced-stage or refractory early-stage MF with focus on analyzing its efficacy and safety. We included 13 MF patients who were treated with single agent etoposide. Patients were identified through the Cutaneous T Cell Lymphoma Database of Indiana University that involves patients treated from 2006 to 2016...
January 9, 2018: Dermatologic Therapy
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