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mycosis fungoides.

Akihiko Yuki, Satoru Shinkuma, Ryota Hayashi, Hiroki Fujikawa, Taisuke Kato, Erina Homma, Yohei Hamade, Osamu Onodera, Masao Matsuoka, Hiroshi Shimizu, Hiroaki Iwata, Riichiro Abe
BACKGROUND: Mycosis fungoides (MF) is the most common cutaneous T-cell lymphoma (CTCL). Early-stage MF patches or plaques often resemble inflammatory skin disorders (ISDs), including psoriasis and atopic dermatitis. Cell adhesion molecule 1 (CADM1), initially identified as a tumor suppressor gene in human non-small-cell lung cancer, has been reported as a diagnostic marker for adult T-cell leukemia/lymphoma (ATLL). OBJECTIVE: We investigated CADM1 expression in MF neoplastic cells, especially during early stages, and evaluated its usefulness as a diagnostic marker for MF...
June 18, 2018: Journal of the American Academy of Dermatology
Pinar Incel Uysal, Onder Bozdogan, Ahmet Atilan, Basak Yalcin
We report a juvenile case of mycosis fungoides with prominent follicular mucinosis (FM). The patient was a 9-year old boy who presented with a 2-month history of enlarging alopecic patch with fine scales on the scalp. Dermatologic examination revealed orange-tan slightly palpable plaques with follicular prominence on his trunk. The patient and his family were not aware of these asymptomatic truncal plaques. Histopathologic examination of both-scalp and trunk-lesions revealed folliculotropic lymphocytic infiltration with mucin...
January 23, 2018: American Journal of Dermatopathology
K Olek-Hrab, J Maj, E Chmielowska, A Jankowska-Konsur, B Olszewska, B Kręcisz, P Iwankowski, M Mackiewicz-Wysocka, Z Adamski, R Nowicki, M Sokolowska-Wojdylo
OBJECTIVE: The first report concerning methotrexate (MTX) in the treatment of Mycosis fungoides (MF) was published in 1964 by Wright. The mechanism of MTX action in the treatment of primary cutaneous T-cell lymphoma (CTCL) has been not explained in detail yet (the anti-inflammatory, immunomodulating, immunosuppressive, and cytostatic actions have been under discussion). PATIENTS AND METHODS: This is a retrospective analysis of 79 MF patients in 4 dermatology clinical centers in Poland...
June 2018: European Review for Medical and Pharmacological Sciences
Serkan Kuyumcu, Ebru Yilmaz, Fikret Büyükkaya, Zeynep Gözde Özkan, Seher Nilgün Ünal
A 52-year-old woman diagnosed with mycosis fungoides was referred for F-FDG PET/CT before treatment for the evaluation of disease severity. The patient also underwent Ga-pentixafor PET/CT for further evaluation. FDG uptake was observed in cervical, axillary, and pelvic lymph nodes and multiple widespread skin lesions throughout the body, suggestive of extensive involvement of mycosis fungoides. All lesions were visually identifiable with high target-to-background ratio on Ga-pentixafor PET/CT which demonstrated marked CXCR4 expression in all lesions that were detected using F-FDG PET/CT...
June 19, 2018: Clinical Nuclear Medicine
Kazuyasu Fujii
Primary cutaneous lymphomas comprise a group of lymphatic malignancies that occur primarily in the skin. They represent the second most common form of extranodal non-Hodgkin's lymphoma and are characterized by heterogeneous clinical, histological, immunological, and molecular features. The most common type is mycosis fungoides and its leukemic variant, Sézary syndrome. Both diseases are considered T-helper cell type 2 (Th2) diseases. Not only the tumor cells but also the tumor microenvironment can promote Th2 differentiation, which is beneficial for the tumor cells because a Th1 environment enhances antitumor immune responses...
2018: Frontiers in Oncology
D A De Luca, E A Zambrano, R L Galimberti, P A Enz
No abstract text is available yet for this article.
June 13, 2018: Actas Dermo-sifiliográficas
Andrew Stevenson Joel Chandranesan, Pradeep Kumar Mada, Frances Ramos-Herberth, David Walsworth, Robert Penn, Ronald Washburn
Hansen's disease, commonly known as leprosy, is a chronic mycobacterial infection caused by Mycobacterium leprae. Although generally uncommon in the United States, it is endemic in the Southern United States. We diagnosed and managed five leprosy patients from Northwest Louisiana, each presenting a distinct set of challenges. A retrospective study was performed to collect demographic, clinical, and laboratory data from our cases. The information was analyzed with a specific focus on associated factors, diagnosis, and management...
April 2018: International Journal of Mycobacteriology
Alejandra Jaque, Alexandra Mereniuk, Shachar Sade, Perla Lansang, Kevin Imrie, Neil H Shear
Eosinophilia, both peripheral and in cutaneous tissue, is not a typical finding in mycosis fungoides; in fact, when faced with a lymphoeosinophilic infiltrate, mycosis fungoides is often not part of initial differential considerations. However, eosinophilia has been described in certain subtypes of mycosis fungoides, namely, in folliculotropic mycosis fungoides. We describe three challenging cases of folliculotropic mycosis fungoides presenting with varied clinical morphologies and a dense lymphoeosinophilic infiltrate and/or severe hypereosinophilia that obscured the final diagnosis for years...
2018: SAGE Open Medical Case Reports
A Combalia, T Estrach
No abstract text is available yet for this article.
June 10, 2018: Actas Dermo-sifiliográficas
Rebeca Manso, Nerea Martínez-Magunacelaya, Itziar Eraña-Tomás, Verónica Monsalvez, José L Rodríguez-Peralto, Pablo-L Ortiz-Romero, Carlos Santonja, Ion Cristóbal, Miguel A Piris, Socorro M Rodríguez-Pinilla
Differentiating early mycosis fungoides (MF) from inflammatory dermatitis is a challenge. We compare the differential expression profile of early-stage MF samples and benign inflammatory dermatoses using microRNA (miRNA) arrays. 114 miRNAs were found to be dysregulated between these entities. The seven most differentially expressed miRNAs between these two conditions were further analyzed using RT-PCR in two series comprising 38 samples of early MFs and 18 samples of inflammatory dermatitis. A series of 51 paraffin-embedded samples belonging to paired stages of 16 MF patients was also analyzed...
2018: PloS One
Melissa Pulitzer, Shamir Geller, Erica Kumar, Denise Frosina, Allison Moskowitz, Steven Horwitz, Patricia Myskowski, Meenal Kheterpal, Alexander Chan, Ahmet Dogan, Achim Jungbluth
AIMS: The diagnosis of cutaneous gamma delta T-cell lymphoma (GDTCL) requires the identification of γδ chains of the T-cell receptor (TCR). Using a new mAb to TCRδ, we evaluated TCRδ expression in formalin fixed paraffin embedded (FFPE) skin tissue from TCRγ-positive cutaneous T-cell lymphoma (CTCL) and assessed TCRδ expression within a spectrum of other cutaneous lymphoproliferative disorders (CLPD). METHODS AND RESULTS: 12 cases (10 patients) with TCRγ-positive CTCL and 132 additional CLPD cases (127 patients) were examined including mycosis fungoides (MF, n=60), cutaneous GDTCL (n=15), subcutaneous panniculitis-like T-cell lymphomas (SPTCL, n=11), and CD30+ lymphoproliferative disorders (CD30+LPDs, n=24)...
June 12, 2018: Histopathology
Hossein Mortazavi, Leila Izadi Firouzabadi, Alireza Ghanadan, Hassan Seirafi, Seyed Naser Emadi, Safoura Shakoei
Mycosis fungoides (MF) is the most common form of cutaneous T-cell lymphoma. Persistent antigenic stimulation has been claimed to play a role in the development of this malignancy. We aimed to show the role of sulfur mustard in the pathogenesis of MF. A 45-year-old man with MF is introduced herein. He was a victim of chemical exposure in 1987 during the Iran-Iraq war. He developed skin lesions 3 years after exposure to sulfur mustard gas at the age of 21. Seven years after his exposure to sulfur mustard gas, a biopsy from the posterior distal part of his calf, which was injured and had bulla, revealed MF...
May 2018: Iranian Journal of Medical Sciences
Iris Amitay-Laish, Ofer Reiter, Hadas Prag-Naveh, Ruben Kershenovich, Emmilia Hodak
BACKGROUND: Retinoids exert their biologic effects by binding to intracellular retinoic-acid receptors (RARs) and/or retinoid X receptors (RXRs). Early-stage mycosis fungoides (MF) has been effectively treated with bexarotene, an RXR-agonist, with overall response (OR) rates 54%-67% and complete response (CR) rates 7%-27%. Data on RAR-agonist monotherapy are limited. OBJECTIVE: To analyze the effectiveness of RAR-agonist monotherapy for early-stage MF. METHODS: Data on patients with early-stage MF treated with acitretin/isotretinoin monotherapy at a tertiary cutaneous lymphoma clinic in 2010-2017 were collected retrospectively from the medical files...
June 11, 2018: Journal of Dermatological Treatment
D Nashan, C M Friedrich, E Geissler, A Schmitt-Graeff, F Klein, F Meiss
BACKGROUND: In addition to a broad and clinically diverse spectrum of known primary cutaneous lymphomas, for which an incidence of 1-3:100,000 is postulated, each year further entities are specified and defined. The goal is the presentation of a case series from daily clinical routine. METHODS: Over a period of 6 years and 2 months, patients consulting the Department of Dermatology, Medical Center University of Freiburg, were registered. Subsequently, collectives of mycosis fungoides (MF), Sezary syndrome (SS), CD30+ lymphoproliferative diseases, single cases with rare primary cutaneous lymphomas, and subcollectives of B‑cell lymphomas were examined...
June 7, 2018: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
C Xu, J Liu, T Wang, Y Luo, Y Liu
BACKGROUND: Early-stage mycosis fungoides (eMF) is a clinical diagnostic challenge because it can mimic inflammatory diseases. Dermoscopy has been reported to be useful in evaluation of eMF in Caucasian patients; however, dermoscopic features of eMF in the Chinese population are lacking. AIM: To determine the validity of dermoscopy in the diagnosis and differential diagnosis of eMF in a Chinese population. METHODS: This was a retrospective study that included a total of 101 patients with eMF (n = 31), chronic dermatitis (CD; n = 36) or plaque psoriasis (PP; n = 34) who were examined dermoscopically, histopathologically and immunohistochemically...
June 6, 2018: Clinical and Experimental Dermatology
Rudolf Stadler, René Stranzenbach
Primary cutaneous T-cell lymphoma (CTCL) comprises the second most common group of extra-nodal non-Hodgkin lymphoma. They represent incurable primary extra-nodal lymphomas of major T-cells, uniformly present in the skin with 1-2% risk of systemic dissemination in mycosis fungoides (MF) which represents the most common subtype of CTCL. In general, long-term antigen stimulation is thought, through key cytokine signalling pathways, to induce an inflammatory response with T-cell proliferation, leading to a clonal malignant T-cell with continuous expansion...
June 4, 2018: Experimental Dermatology
Tiziana Borra, Ana Custrin, Andrea Saggini, Regina Fink-Puches, Carlo Cota, William Vermi, Fabio Facchetti, Lorenzo Cerroni
Pityriasis lichenoides (PLs) is an uncommon skin disease of unknown etiology. In recent years, an atypical form of PL has been described, showing overlapping features with mycosis fungoides (MF) and lymphomatoid papulosis. We studied 66 patients with an initial histopathologic diagnosis of PL (M:F=34:32; median age, 25 y; range, 7 to 85 y). According to clinical and phenotypic features, cases were classified into 4 categories: (1) Conventional PL (characteristic clinical features of PL without phenotypic aberrations) (n=20; M:F=8:12; median age, 37 y; range, 9 to 74 y); (2) Atypical form of PL (characteristic clinical features of PL with phenotypic aberrations) (n=25; M:F=16:9; median age, 21 y; range, 7 to 72 y)...
May 30, 2018: American Journal of Surgical Pathology
S Geller, M Pulitzer, P L Myskowski
Follicular mucinosis (FM) can present as an acneiform eruption, and is usually a benign variant of primary FM unrelated to cutaneous T-cell lymphoma (CTCL). We report two cases of women in their twenties who presented with an acneiform rash on the face, arms and back. In both cases, pathological evaluation of the facial papules revealed predominantly mucinous degeneration of the follicular epithelium, with insufficient lymphocytic infiltration or atypia to diagnose mycosis fungoides. These cases are similar to previous reports of acneiform FM...
May 30, 2018: Clinical and Experimental Dermatology
Natalia Buchely, Rami Al-Rohil, Phyu P Aung, George Jour, Carlos Torres-Cabala, Victor G Prieto, Doina Ivan
Mycosis fungoides (MF) is the most common variant of cutaneous T-cell lymphomas (CTCL). Large cell transformation of MF has been associated with disease progression and overall poor outcome. The expression of CD30, which defines anaplastic large cell lymphoma (ALCL) and lymphomatoid papulosis (LyP), might also occur in a subset of patients with MF, with or without large cell transformation. Brentuximab vedotin is an anti-CD30 monoclonal antibody which has been proven to be a safe and effective therapeutic agent in the treatment of CD30-positive lymphomas, such as Hodgkin lymphoma and ALCL...
May 27, 2018: Journal of Cutaneous Pathology
Lei Qiu, Fengjie Liu, Shengguo Yi, Xueying Li, Xiaoqing Liu, Cheng Xiao, Christine Guo Lian, Ping Tu, Yang Wang
DNA hydroxymethylation at the 5 position of cytosine (5-hmC) is a product of the ten-eleven translocation (TET) family of DNA hydroxylases. Accumulating evidence shows that loss of 5-hmC is critical for various biological and pathological processes. However, its level in cutaneous T cell lymphoma remains largely unknown. Here we report that the loss of 5-hmC is an epigenetic hallmark of cutaneous T cell lymphoma (CTCL), with diagnostic and prognostic implications. Immunohistochemistry staining on 90 mycosis fungoides (MF) cases demonstrated a significant decrease of 5-hmC staining in CD4+ T cells in patch and tumor stages, especially in MF-LCT, compared to benign inflammatory dermatoses...
May 24, 2018: Journal of Investigative Dermatology
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