Gun Tae Jung, Minha Kim, Jong Suk Song, Tae Im Kim, Tae Young Chung, Chul Young Choi, Hyun Seong Kim, Woo Ju An, Su Jin Jeong, Hye Sun Lee, Soyoung Jeon, Kwang Pyo Kim, Hyung Keun Lee
PURPOSE: To identify specific dry eye disease (DED) tear biomarker(s) using tear proteomic analysis, clinical parameters, and their correlations before and after DED treatment. METHODS: A prospective, double-blinded, national multicenter clinical study was performed using data from 80 DED patients. The patients were treated with 0.1% cyclosporine (CsA, n = 28), 0.05% CsA (n = 26), or 3% diquafosol (DQS, n = 26) eye drops, and tear proteome changes and clinical outcomes (tear break-up time [TBUT], corneal erosion [Cor-Er], conjunctival erosion [Conj-Er], and symptom assessment in dry eye [SANDE] scores) were observed at 4, 8, and 12 weeks...
April 23, 2023: Ocular Surface