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cancer reconstruction

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https://www.readbyqxmd.com/read/28212385/the-effect-of-tumour-size-on-drug-transport-and-uptake-in-3-d-tumour-models-reconstructed-from-magnetic-resonance-images
#1
Wenbo Zhan, Wladyslaw Gedroyc, Xiao Yun Xu
Drug transport and its uptake by tumour cells are strongly dependent on tumour properties, which vary in different types of solid tumours. By simulating the key physical and biochemical processes, a numerical study has been carried out to investigate the transport of anti-cancer drugs in 3-D tumour models of different sizes. The therapeutic efficacy for each tumour is evaluated by using a pharmacodynamics model based on the predicted intracellular drug concentration. Simulation results demonstrate that interstitial fluid pressure and interstitial fluid loss vary non-linearly with tumour size...
2017: PloS One
https://www.readbyqxmd.com/read/28210551/factors-influencing-the-decision-to-pursue-immediate-breast-reconstruction-after-mastectomy-for-breast-cancer
#2
Mariska Weenk, Philipp Wunschel, Erwin Heine, Luc J Strobbe
BACKGROUND: Immediate breast reconstruction (IBR) after mastectomy has shown to be oncologically safe and to improve quality of life in breast cancer patients. However, most women undergoing mastectomy do not undergo IBR. In this study, we aim to identify breast surgeon-related factors in considering IBR and factors affecting patients' decision to choose for IBR. METHODS: Retrospective analysis of the records of breast cancer patients who underwent mastectomy with or without IBR between 2010 and 2013...
February 2017: Gland Surgery
https://www.readbyqxmd.com/read/28210548/does-neoadjuvant-chemotherapy-affect-morbidity-mortality-reoperations-or-readmissions-in-patients-undergoing-lumpectomy-or-mastectomy-for-breast-cancer
#3
Jeffrey Landercasper, Barbara Bennie, Mallory S Bray, Choua A Vang, Jared H Linebarger
BACKGROUND: The influence of neoadjuvant chemotherapy (NAC) prior to breast cancer surgery on postoperative complications is unclear. Our objective was to determine whether NAC was associated with postoperative outcomes in patients undergoing lumpectomy or mastectomy without reconstruction. METHODS: Patients meeting inclusion criteria were identified from the National Surgical Quality Improvement Program (NSQIP) database participant user files from 2005 through 2012, after which NSQIP discontinued the NAC variable...
February 2017: Gland Surgery
https://www.readbyqxmd.com/read/28209952/-functional-results-of-digestive-tract-reconstruction-after-gastrectomy
#4
V V Оlекsеnко, S V Efetov, V A Zakharov, K A Aliyev, D M Al-Nsour
AIM: To substantiate and to prove the advantages of the new method of gastroplasty in comparison with traditional loop reconstruction of digestive tract after gastrectomy. MATERIAL AND METHODS: It was performed prospective comparative study of surgical treatment of 431 patients with gastric cancer who underwent gastrectomy with different variants of digestive tract reconstruction. The main group (146 patients) consisted of patients in whom original technique including establishment of food reservoir in initial jejunal part during reconstruction was applied...
2017: Khirurgiia
https://www.readbyqxmd.com/read/28206777/partner-social-constraints-and-early-stage-breast-cancer-longitudinal-associations-with-psychosexual-adjustment
#5
Emily C Soriano, Amy K Otto, Scott D Siegel, Jean-Philippe Laurenceau
Women with breast cancer (BC) who perceive social constraints on their disclosure of cancer-related concerns are more likely to experience distress and have difficulty adjusting after diagnosis. Much of the existing research on psychosocial adjustment is cross-sectional in nature and an important area of concern that has received little attention is psychosexual adjustment to cancer surgery and treatment. This study examined whether perceived partner social constraints were associated with psychosexual adjustment over time in 108 BC survivors...
February 16, 2017: Journal of Family Psychology: JFP
https://www.readbyqxmd.com/read/28205306/multi-site-quality-and-variability-analysis-of-3d-fdg-pet-segmentations-based-on-phantom-and-clinical-image-data
#6
Reinhard R Beichel, Brian J Smith, Christian Bauer, Ethan J Ulrich, Payam Ahmadvand, Mikalai M Budzevich, Robert J Gillies, Dmitry Goldgof, Milan Grkovski, Ghassan Hamarneh, Qiao Huang, Paul E Kinahan, Charles M Laymon, James M Mountz, John P Muzi, Mark Muzi, Sadek Nehmeh, Matthew J Oborski, Yongqiang Tan, Binsheng Zhao, John J Sunderland, John M Buatti
PURPOSE: Radiomics utilizes a large number of image-derived features for quantifying tumor characteristics that can in turn be correlated with response and prognosis. Unfortunately, extraction and analysis of such image-based features is subject to measurement variability and bias. The challenge for radiomics is particularly acute in Positron Emission Tomography (PET) where limited resolution, a high noise component related to the limited stochastic nature of the raw data, and the wide variety of reconstruction options confound quantitative feature metrics...
February 2017: Medical Physics
https://www.readbyqxmd.com/read/28205002/prognostic-impacts-of-postoperative-complications-in-patients-with-intrahepatic-cholangiocarcinoma-after-curative-operations
#7
Tatsunori Miyata, Yo-Ichi Yamashita, Takanobu Yamao, Naoki Umezaki, Masayo Tsukamoto, Yuki Kitano, Kensuke Yamamura, Kota Arima, Takayoshi Kaida, Shigeki Nakagawa, Katsunori Imai, Daisuke Hashimoto, Akira Chikamoto, Takatoshi Ishiko, Hideo Baba
BACKGROUND: The postoperative complication is one of an indicator of poor prognosis in patients with several gastroenterological cancers after curative operations. We, herein, examined prognostic impacts of postoperative complications in patients with intrahepatic cholangiocarcinoma after curative operations. METHODS: We retrospectively analyzed 60 patients with intrahepatic cholangiocarcinoma who underwent primary curative operations from June 2002 to February 2016...
February 15, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28203500/reconstructive-surgery-for-bronchopleural-fistula-and-empyema-new-application-of-free-fascial-patch-graft-combined-with-free-flap
#8
Minoru Sakuraba, Hiroki Umezawa, Shimpei Miyamoto, Masahide Fujiki, Takuya Higashino, Azusa Oshima, Masahiro Tsuboi
BACKGROUND: Postoperative bronchopleural fistula (BPF) and empyema are not uncommon after lung cancer surgery. Some patients require reconstructive surgery to achieve wound healing. In this report, we describe a novel method of reconstructive surgery for BPF and empyema. METHODS: From 1996 through 2014, we performed reconstructive surgery for the treatment of BPF and empyema in 13 cases. BPF or a pulmonary fistula was present in 11 patients at the time of reconstruction...
January 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28203403/clinic-application-of-tissue-engineered-bronchus-for-lung-cancer-treatment
#9
Qiang Tan, Ruijun Liu, Xiaoke Chen, Jingxiang Wu, Yinggen Pan, Shun Lu, Walter Weder, Qingquan Luo
BACKGROUND: Delayed revascularization process and substitute infection remain to be key challenges in tissue engineered (TE) airway reconstruction. We propose an "in-vivo bioreactor" design, defined as an implanted TE substitutes perfused with an intra-scaffold medium flow created by an extracorporeal portable pump system for in situ organ regeneration. The perfusate keeps pre-seeded cells alive before revascularization. Meanwhile the antibiotic inside the perfusate controls topical infection...
January 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28198179/breast-reconstruction-after-mastectomy-for-breast-cancer-comparative-analysis-of-early-and-delayed-reconstruction
#10
William Seidel, Jorge Bins Ely, Daniel Ongaratto Barazzetti, Renata Della Giustina, Gustavo P Walter, Thiago A Ferri, Rosemeri Maurici, Janaína L Narciso-Schiavon
BACKGROUND: Early reconstruction after mastectomy for breast cancer with definitive implants has been widely used, especially with the evolution of conservative surgical breast cancer treatments. We aimed to identify different characteristics associated with plastic surgery, based on immediate or delayed reconstruction time and evaluate quality of life in patients undergoing mastectomy for cancer. METHODS: This is a cross-sectional analytical study that evaluated adult patients undergoing mastectomy for breast cancer and breast reconstruction in Plastic Surgery Service at a tertiary hospital...
February 14, 2017: Minerva Chirurgica
https://www.readbyqxmd.com/read/28197820/lung-cancer-screening-with-ultra-low-dose-ct-using-full-iterative-reconstruction
#11
Masayo Fujita, Toru Higaki, Yoshikazu Awaya, Toshio Nakanishi, Yuko Nakamura, Fuminari Tatsugami, Yasutaka Baba, Makoto Iida, Kazuo Awai
PURPOSE: To investigate the diagnostic capability of ultra-low-dose CT (ULDCT) with full iterative reconstruction (f-IR) for lung cancer screening. MATERIALS AND METHODS: All underwent ULDCT and/or low-dose CT (LD-CT) on a 320-detector scanner. ULDCT images were reconstructed with f-IR. We qualitatively and quantitatively studied 95 nodules in 69 subjects. Two radiologists classified the nodules on ULDCT images as solid-, part-solid-, and pure ground-glass (PGG) and recorded their mean size...
February 14, 2017: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/28197773/change-in-tongue-pressure-in-patients-with-head-and-neck-cancer-after-surgical-resection
#12
Yoko Hasegawa, Kazuma Sugahara, Tatsuyuki Fukuoka, Shota Saito, Ayumi Sakuramoto, Nobuhide Horii, Saori Sano, Kana Hasegawa, Yuta Nakao, Tomoki Nanto, Kanenori Kadoi, Kuniyasu Moridera, Kazuma Noguchi, Kazuhisa Domen, Hiromitsu Kishimoto
Tongue pressure is reportedly associated with dysphagia. This study investigated relationships among characteristics of head and neck cancer, tongue pressure and dysphagia screening tests performed in patients with head and neck cancer during the acute phase after surgical resection. Fifty-seven patients (36 men, 21 women; age range 26-95 years) underwent surgical resection and dysphagia screening tests (Repetitive Saliva Swallowing Test, Water Swallowing Test, Modified Water Swallowing Test and Food Test) and pre- and postoperative measurement of tongue pressure at 5 time points (preoperatively, and 1-2 weeks and 1, 2, and 3 months postoperatively)...
February 14, 2017: Odontology
https://www.readbyqxmd.com/read/28195888/a-novel-application-of-double-paddle-peroneal-chimeric-flap-as-external-sentinel-monitor-in-hypopharyngeal-reconstruction
#13
Jung-Hua Hsueh, Yu-Hsuan Hsieh, Ying-Sheng Lin, Yaoh-Shiang Lin, Kuo-Chung Yang, Wen-Chung Liu
OBJECTIVES: Monitoring the viability of buried free flaps in hypopharyngeal reconstruction is difficult. Various methods have been proposed to monitor these buried flaps, but limitations remain. METHOD: We present a method of using double-paddle chimeric peroneal flaps that permanently externalizes a flap skin paddle as a monitoring paddle in hypopharyngeal reconstructions. This study was performed in a medical center in southern Taiwan; between 2013 and 2015, 10 patients underwent double-paddle chimeric peroneal flap reconstruction in advanced stages of hypopharyngeal cancer...
February 14, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28195672/predictors-of-satisfaction-and-quality-of-life-following-post-mastectomy-breast-reconstruction
#14
Hannah Matthews, Natalie Carroll, Derek Renshaw, Andrew Turner, Alan Park, Jo Skillman, Kate McCarthy, Elizabeth A Grunfeld
OBJECTIVE: Breast reconstruction is associated with multiple psychological benefits. However, few studies have identified clinical and psychological factors associated with improved satisfaction and quality of life. This study examined factors which predict satisfaction with breast appearance, outcome satisfaction and quality of life following post-mastectomy breast reconstruction. METHODS: Women who underwent post-mastectomy breast reconstruction between 2010 and 2016 received a postal questionnaire consisting of: The BREAST-Q Patient Reported Outcomes Instrument, The European Organisation for Research and Treatment of Cancer QLQ-30 Questionnaire, The Patient and Observer Scar Assessment Scale and a series of Visual-Analogue Scales...
February 13, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28194591/complications-in-diep-flap-breast-reconstruction-after-mastectomy-for-breast-cancer-a-prospective-cohort-study-comparing-unilateral-and-bilateral-reconstructions
#15
EDITORIAL
Mark V Schaverien, Charles E Butler
No abstract text is available yet for this article.
February 13, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28194541/undermining-plastic-surgery-as-a%C3%A2-possible-option-for-treating-basal-cell-carcinoma-of-the-forehead
#16
Georgi Tchernev, Ivan Pidakev, Ilia Lozev, Torello Lotti, Jose Carlos Cardoso, James W Patterson
Basal cell carcinoma (BCC) is the most common cutaneous cancer. Although most cases can be cured with simple surgical procedures and are associated with a good prognosis, a minority of BCCs may pose significant therapeutic challenges. This occurs mostly in cases of so-called advanced BCC, which a loosely defined term that encompasses locally advanced lesions and tumors with metastatic spread. Treatment of these cases is often complex and sometimes may need combinations of therapeutic modalities, including surgery, radiotherapy and/or targeted therapy directed towards sonic hedgehog (SHH) signaling pathways, such as vismodegib...
February 13, 2017: Wiener Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28193444/surgical-navigation-a-systematic-review-of-indications-treatments-and-outcomes-in-oral-and-maxillofacial-surgery
#17
REVIEW
Iman Azarmehr, Kasper Stokbro, R Bryan Bell, Torben Thygesen
PURPOSE: This systematic review investigates the most common indications, treatments, and outcomes of surgical navigation (SN) published from 2010 to 2015. The evolution of SN and its application in oral and maxillofacial surgery have rapidly developed over recent years, and therapeutic indications are discussed. MATERIALS AND METHODS: A systematic search in relevant electronic databases, journals, and bibliographies of the included articles was carried out. Clinical studies with 5 or more patients published between 2010 and 2015 were included...
January 18, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28192525/a-prospective-study-of-breast-anthropomorphic-measurements-volume-and-ptosis-in-605-asian-patients-with-breast-cancer-or-benign-breast-disease
#18
Nai-Si Huang, Chen-Lian Quan, Miao Mo, Jia-Jian Chen, Ben-Long Yang, Xiao-Yan Huang, Jiong Wu
OBJECTIVES: The current study aims to summarize breast anthropomorphic measurement features in Chinese patients with breast diseases and to investigate their potential correlations with demographic factors. MATERIALS AND METHODS: Fifteen breast anthropomorphic parameters of 605 Chinese female patients were collected prospectively. Breast ptosis status was scaled by two methods and breast volume was calculated according to a modified formula of BREAST-V. RESULTS: Among 1210 breasts, the average breast volume was 340...
2017: PloS One
https://www.readbyqxmd.com/read/28192280/iterative-reconstruction-of-sipm-light-response-functions-in-a-square-shaped-compact-gamma-camera
#19
Andrey Morozov, Francisco Alves, Joao Marcos, Raimundo Martins, Luis Pereira, Vladimir Solovov, Vitaly Chepel
Compact gamma cameras with a square-shaped monolithic scintillator crystal and an array of silicon photomultipliers (SiPMs) are actively being developed for applications in areas such as small animal imaging, cancer diagnostics and radiotracer guided surgery. Statistical methods of position reconstruction, which are potentially superior to the traditional centroid method, require accurate knowledge of the spatial response of each photomultiplier. Using both Monte Carlo simulations and experimental data obtained with a camera prototype, we show that the spatial response of all photomultipliers (light response functions) can be parameterized with axially symmetric functions obtained iteratively from flood field irradiation data...
February 13, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28191589/assessment-of-musculoskeletal-impairment-in-head-and-neck-cancer-patients
#20
Michael K Ghiam, Kyle Mannion, Mary S Dietrich, Kristen L Stevens, Jill Gilbert, Barbara A Murphy
PURPOSE: This study aims to describe the types of musculoskeletal impairment in head and neck cancer survivors and to evaluate objective and subjective measures of musculoskeletal impairment and identify areas of need in future studies. METHODS: This is a cross-sectional pilot study of 29 head and neck cancer patients who were treated with resection and reconstruction. Subjective measures of musculoskeletal impairment (Neck Disability Index, Shoulder Pain and Disability Index, Vanderbilt Head and Neck Symptom Survey, General Symptom Survey) were collected and compared to objective measures (Cervical Range of Motion Device, Inter-incisal Distance)...
February 13, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
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