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https://www.readbyqxmd.com/read/28437785/the-retina-of-asian-and-african-elephants-comparison-of-newborn-and-adult
#1
Heidrun Kuhrt, Andreas Bringmann, Wolfgang Härtig, Gudrun Wibbelt, Leo Peichl, Andreas Reichenbach
Elephants are precocial mammals that are relatively mature as newborns and mobile shortly after birth. To determine whether the retina of newborn elephants is capable of supporting the mobility of elephant calves, we compared the retinal structures of 2 newborn elephants (1 African and 1 Asian) and 2 adult animals of both species by immunohistochemical and morphometric methods. For the first time, we present here a comprehensive qualitative and quantitative characterization of the cellular composition of the newborn and the adult retinas of 2 elephant species...
April 25, 2017: Brain, Behavior and Evolution
https://www.readbyqxmd.com/read/28436374/factors-influencing-treatment-of-proximal-femoral-fractures
#2
Sławomir Dudko, Paweł Kosior, Damian Kusz, Anna Wagner, Marcin Kusz, Karolina Godyń
BACKGROUND: Orthopaedics and traumatology departments are dominated by patients with proximal femoral fractures, who represent 20-30% of all patients treated there. The aim of this study was identification and evaluation of factors influencing treatment of proximal femoral fractures. MATERIAL AND METHODS: Between 2008 and 2015, we treated 424 femoral neck fractures and 442 trochanteric fractures in patients over 40 y/o. The impact of fracture location (femoral neck/trochanteric), character (non-displaced/displaced) and the patient's general condition (metrical/biological age, health condition) on qualification and treatment used (fixations/hip pro-sthesis/non-operative) was analyzed...
January 26, 2017: Ortopedia, Traumatologia, Rehabilitacja
https://www.readbyqxmd.com/read/28399092/-the-affective-pathology-in-patients-with-adolescent-bulimia-nervosa
#3
V V Grachev
AIM: To investigate affective pathology in patients with adolescent bulimia nervosa (BN) and to analyze comorbid mutual influences of these clinical entities. MATERIAL AND METHODS: A sample consisted of 52 young female patients, aged from 13.9 to 17.4 years, who simultaneously meet ICD-10 criteria of F50.2 - typical BN and F30-F39 - mood disorders. The Eating Attitudes Test (EAT-26) and the Beck Depression Inventory were used for psychometric assessment. Duration of follow-up ranged from 1 to 7 years...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28397069/licl-treatment-induces-programmed-cell-death-of-schwannoma-cells-through-akt-and-mtor-mediated-necroptosis
#4
Ying Wang, Qi Zhang, Bo Wang, Peng Li, Pinan Liu
Lithium is considered a first-line therapy for the treatment of bipolar disorder and was recently shown to be associated with a reduced overall cancer risk. A growing body of evidence has indicated the potential antitumor benefits of this drug. Lithium likely functions as an antitumor agent. In this study, we found that lithium chloride (LiCl) significantly inhibits the proliferation of both RT4 cells and human NF2-associated primary schwannoma cells by inhibiting the expression of apoptosis-related proteins...
April 10, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28384714/organotypic-cultures-of-adult-mouse-retina-morphologic-changes-and-gene-expression
#5
Brigitte Müller, Franziska Wagner, Birgit Lorenz, Knut Stieger
Purpose: The purpose of this study was characterization of adult murine neuroretina in organ culture to investigate its suitability for use in preclinical therapeutic applications. In retinal disorders, neurodegeneration of mature retinal cells takes place. Therefore, neonatal retina cultures are not adequate for therapeutic applications, such as genome editing, as the retina is still developing with cells dividing and differentiating into highly specialized cell types such as photoreceptors...
April 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28365865/socio-demographic-and-clinical-characterization-of-patients-with-bipolar-disorder-i-vs-ii-a-nationwide-italian-study
#6
A Carlo Altamura, Massimiliano Buoli, Bruno Cesana, Bernardo Dell'Osso, Gianluigi Tacchini, Umberto Albert, Andrea Fagiolini, Andrea de Bartolomeis, Giuseppe Maina, Emilio Sacchetti
Bipolar disorders (BDs) are prevalent, comorbid and disabling conditions, associated with the highest suicide risk among psychiatric illnesses. In the last few years, new efforts to better characterize the socio-demographic and clinical profiles of BD type I vs II have been documented by several reports, with novel and insightful findings in the field. The present multicenter study aimed to provide a comprehensive and reliable representation of the Italian reality, through the analysis of the largest national sample of bipolar patients collected so far...
April 1, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28360522/long-term-efficacy-and-safety-of-lamotrigine-for-all-types-of-bipolar-disorder
#7
Yoshinori Watanabe, Seiji Hongo
BACKGROUND: We investigated whether the long-term efficacy and safety of lamotrigine (LTG) for bipolar disorder (BP) differs between disease types (BP-I, BP-II, or BP not otherwise specified [BP-NOS]), and the efficacy of the concomitant use of antidepressants (ADs). METHODS: For >1 year, we observed 445 outpatients with BP (diagnosed by DSM-IV criteria) who initiated LTG treatment between July 1 and October 31, 2011, using the Himorogi Self-rating Depression (HSDS) and Anxiety Scales and the Clinical Global Impression-Improvement scale and also recorded adverse events...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28341269/ultrasonic-bipolar-and-integrated-energy-devices-comparing-heat-spread-in-collateral-tissues
#8
Megan K Applewhite, Michael G White, Benjamin C James, Layth Abdulrasool, Edwin L Kaplan, Peter Angelos, Raymon H Grogan
BACKGROUND: Integrated devices incorporating ultrasonic and bipolar technology have been used in laparoscopic surgery, however, are not yet incorporated into open operations. Here, we compare thermal spread and recurrent laryngeal nerve (RLN) functional data of the integrated THUNDERBEAT Open Fine Jaw device, the bipolar Ligasure Small Jaw, and the ultrasonic Harmonic Focus for open thyroidectomy. MATERIALS AND METHODS: The three energy devices were compared in a live porcine model using three tissue types including liver, muscle, and thyroid...
January 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28323174/multicenter-investigation-of-an-implantable-cardioverter-defibrillator-algorithm-to-detect-oversensing
#9
Nicolas Welte, Marc Strik, Romain Eschalier, Pierre Mondoly, Pascal Defaye, Antonio Frontera, Philippe Ritter, Michel Haïssaguerre, Sylvain Ploux, Jayanthi Koneru, Kenneth A Ellenbogen, Pierre Bordachar
BACKGROUND: The SecureSense right ventricular (RV) lead noise discrimination algorithm is designed to detect lead fracture and other types of oversensing in order to decrease inappropriate therapy. OBJECTIVE: We studied the real-life accuracy of the SecureSense algorithm in implantable cardioverter-defibrillator (ICD) patients followed by remote monitoring across multiple centers. METHODS: Across 3 French centers, we studied 486 patients with a St Jude Medical device who were followed by remote monitoring and who had the SecureSense algorithm activated...
March 18, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28316962/wiring-techniques-for-the-fixation-of-trochanteric-fragments-during-bipolar-hemiarthroplasty-for-femoral-intertrochanteric-fracture-clinical-study-and-technical-note
#10
Joong-Myung Lee, Yongsuk Cho, Junhyun Kim, Dong-Won Kim
PURPOSE: Femoral intertrochanteric fractures are common in the elderly. Appropriate surgical fixation of trochanteric fracture fragments can restore normal anatomical structure and ambulation, and can aid in the recovery of biomechanical function of the hip. We evaluated clinical outcomes of bipolar hemiarthroplasty using a wiring technique for trochanteric fracture fragment fixation. MATERIALS AND METHODS: From September 2006 to February 2015, a total of 260 cases underwent simultaneous bipolar hemiarthroplasty and wire fixation...
March 2017: Hip & Pelvis
https://www.readbyqxmd.com/read/28316877/progression-of-pro23his-retinopathy-in-a-miniature-swine-model-of-retinitis-pigmentosa
#11
Patrick A Scott, Juan P Fernandez de Castro, Paul J DeMarco, Jason W Ross, Josephat Njoka, Eric Walters, Randall S Prather, Maureen A McCall, Henry J Kaplan
PURPOSE: We characterize the progression of retinopathy in Filial 1 (F1) progeny of a transgenic (Tg) founder miniswine exhibiting severe Pro23His (P23H) retinopathy. METHODS: The F1 TgP23H miniswine progeny were created by crossing TgP23H founder miniswine 53-1 with wild type (WT) inbred miniature swine. Scotopic (rod-driven) and photopic (cone-driven) retinal functions were evaluated in F1 TgP23H and WT littermates using full field electroretinograms (ffERGs) at 1, 2, 3, 6, 9, 12, and 18 months of age, as well as the Tg founder miniswine at 6 years of age...
March 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/28315278/peeking-into-sigma-1-receptor-functions-through-the-retina
#12
Timur A Mavlyutov, Lian-Wang Guo
This review discusses recent advances towards understanding the sigma-1 receptor (S1R) as an endogenous neuro-protective mechanism in the retina , a favorable experimental model system. The exquisite architecture of the mammalian retina features layered and intricately wired neurons supported by non-neuronal cells. Ganglion neurons, photoreceptors , as well as the retinal pigment epithelium, are susceptible to degeneration that leads to major retinal diseases such as glaucoma , diabetic retinopathy , and age-related macular degeneration (AMD), and ultimately, blindness...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28280345/screening-for-bipolar-disorder-among-migraineurs-the-impact-of-migraine-bipolar-disorder-comorbidity-on-disease-characteristics
#13
Yigit Kivilcim, Merih Altintas, Fusun Mayda Domac, Erkal Erzincan, Huseyin Gülec
PURPOSE: The aim of this study was to evaluate the prevalence of comorbid bipolar disorder (BD) among migraineurs and the impact of migraine-BD comorbidity on disease characteristics. PATIENTS AND METHODS: A total of 120 adult patients diagnosed with migraine at a single tertiary care center were included in this cross-sectional study. Data on sociodemographic and migraine-related characteristics, family history of psychiatric diseases, comorbid psychiatric diseases, and first-episode characteristics were recorded...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28271731/ketamine-augmentation-rapidly-improves-depression-scores-in-inpatients-with-treatment-resistant-bipolar-depression
#14
Janusz K Rybakowski, Agnieszka Permoda-Osip, Alicja Bartkowska-Sniatkowska
OBJECTIVE: To study the clinical effect of a single ketamine infusion, 0.5 mg/kg body weight, in bipolar depressive patients receiving mood-stabilising drugs, not improving on antidepressants. Previously, in such patients, we had found a correlation between clinical efficacy, serum brain-derived neurotrophic factor and vitamin B12 levels and a rapid improvement in neurocognitive performance. METHODS: The study included 53 patients (13 men, 40 women), aged 22-81 years, receiving ≥1 mood-stabilising medications of the first and/or second generation...
March 8, 2017: International Journal of Psychiatry in Clinical Practice
https://www.readbyqxmd.com/read/28264741/mixed-features-evolution-of-the-concept-past-and-current-definitions-and-future-prospects
#15
Alan C Swann
Mixed states address the relationships between episodes and the course of an illness, presenting significant clinical challenges. Recurrent affective disorders were described thousands of years ago as dimensional disturbances of the basic elements of behavior, combining the characteristics of what we would now consider manic and depressive episodes. It was recognized from the beginning that combinations of depressive and manic features are associated with a severe illness course, including increased suicide risk...
March 7, 2017: CNS Spectrums
https://www.readbyqxmd.com/read/28262260/-suicidal-attempts-in-child-and-adolescent-and-bipolar-disorders
#16
N Dugand, S Thümmler, C Pradier, F Askenazy
BACKGROUND: Child and adolescent psychiatrists are frequently confronted with suicide attempts and comorbid mood disorders. Diagnoses of juvenile bipolar disorders (BD) are rare and controversial and standardized assessment is helpful for a reliable diagnosis. The main objective of this study was to identify the number of juvenile bipolar disorder diagnoses according to DSM-5 criteria in a population of children and adolescents hospitalized for suicide attempts. Secondary objectives were the assessment of a patient's characteristics and the comparison of suicide attempt recurrence during 12 months of follow-up...
March 2, 2017: L'Encéphale
https://www.readbyqxmd.com/read/28261143/improving-major-depressive-episode-assessment-a-new-tool-developed-by-formal-psychological-assessment
#17
Francesca Serra, Andrea Spoto, Marta Ghisi, Giulio Vidotto
Aim: Major depressive episode (MDE) can manifest with different features. Discriminating between different types of MDEs is crucial for proper treatment. The aim of this study is to propose a new tool for MDE assessment in bipolar disorder (BD) or major depressive disorder (MDD) to overcome some limitations of current rating scales. The proposed tool investigates all of the clinical features of different MDEs and gives qualitative information, differentiating patients with the same score but different symptoms and psychopathology severity...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28260178/combined-open-bipolar-monteggia-and-galeazzi-fracture-a-case-report-with-a-1-year-follow-up
#18
Christos Koutserimpas, Georg Tsironis, Antonios Salasidis, Phillipp Swatoch, Konstantin Tsironis
Monteggia and Galeazzi fractures account for 1-5% of total forearm fractures. A combined Monteggia and Galeazzi fracture is an extremely rare injury. We present a case of a Gustillo-Henderson type 2 open combined bipolar Monteggia and Galeazzi fracture, as well as fracture of the ulnar coronoid process in a 49-year old male. The patient was treated surgically, with open reduction and internal fixation. At 6 months postoperative, he was diagnosed with pseudarthrosis and underwent surgery with autologous bone grafting from the iliac crest...
March 4, 2017: Strategies in Trauma and Limb Reconstruction
https://www.readbyqxmd.com/read/28246665/p-type-transition-metal-doping-of-large-area-mos2-thin-films-grown-by-chemical-vapor-deposition
#19
E Z Xu, H M Liu, K Park, Z Li, Y Losovyj, M Starr, M Werbianskyj, H A Fertig, S X Zhang
Two-dimensional transition metal dichalcogenides (e.g. MoS2) have recently emerged as a promising material system for electronic and optoelectronic applications. A major challenge for these materials, however, is to realize bipolar electrical transport properties (i.e. both p-type and n-type conduction), which is critical for enhancing device performance and functionalities. Here, we demonstrate the transition metal zinc as a p-type dopant in the otherwise n-type MoS2, through systematic characterizations of large area Zn-doped MoS2 thin films grown by a one-step chemical vapor deposition (CVD) approach...
March 1, 2017: Nanoscale
https://www.readbyqxmd.com/read/28235557/multidisciplinary-consensus-on-the-therapeutic-recommendations-for-iatrogenic-hyperprolactinemia-secondary-to-antipsychotics
#20
REVIEW
Ángel L Montejo, Celso Arango, Miquel Bernardo, José L Carrasco, Benidicto Crespo-Facorro, Juan J Cruz, Javier Del Pino-Montes, Miguel A García-Escudero, Clemente García-Rizo, Ana González-Pinto, Ana I Hernández, Manuel Martín-Carrasco, Fermín Mayoral-Cleries, Jaqueline Mayoral-van Son, M Teresa Mories, Isabella Pachiarotti, Jesús Pérez, Salvador Ros, Eduard Vieta
Hyperprolactinemia is an underappreciated/unknown adverse effects of antipsychotics. The consequences of hyperprolactinemia compromise therapeutic adherence and can be serious. We present the consensus recommendations made by a group of experts regarding the management of antipsychotic-induced hyperprolactinemia. The current consensus was developed in 3 phases: 1, review of the scientific literature; 2, subsequent round table discussion to attempt to reach a consensus among the experts; and 3, review by all of the authors of the final conclusions until reaching a complete consensus...
April 2017: Frontiers in Neuroendocrinology
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