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https://www.readbyqxmd.com/read/28480486/clinical-correlates-of-age-at-onset-distribution-in-bipolar-disorder-a-comparison-between-diagnostic-subgroups
#1
Mirko Manchia, Giuseppe Maina, Bernardo Carpiniello, Federica Pinna, Luca Steardo, Virginia D'Ambrosio, Virginio Salvi, Martin Alda, Alfonso Tortorella, Umberto Albert
BACKGROUND: Admixture analysis of age at onset (AAO) has helped delineating the clinical profile of early onset (EO) bipolar disorder (BD). However, there is scarce evidence comparing the distributional properties of AAO as well as the clinical features of EO BD type 1 (BD1) with EO BD type 2 (BD2). To this end, we studied 515 BD patients (224 BD1, 279 BD2, and 12 BD not otherwise specified [NOS]) diagnosed according to DSM-IV-TR criteria. METHODS: AAO was defined as the first reliably diagnosed hypo/manic or depressive episode according to diagnostic criteria...
December 2017: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/28472856/multiple-cell-types-form-the-vip-amacrine-cell-population
#2
Luis Pérez de Sevilla Müller, Alexander Solomon, Kristopher Sheets, Hinekura Hapukino, Allen Rodriguez, Nicholas C Brecha
Amacrine cells are a heterogeneous group of interneurons that form microcircuits with bipolar, amacrine and ganglion cells to process visual information in the inner retina. This study has characterized the morphology, neurochemistry and major cell types of a VIP-ires-Cre amacrine cell population. VIP-tdTomato and -Confetti (Brainbow2.1) mouse lines were generated by crossing a VIP-ires-Cre line with either a Cre-dependent tdTomato or Brainbow2.1 reporter line. Retinal sections and whole-mounts were evaluated by quantitative, immunohistochemical and intracellular labeling approaches...
May 4, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28472282/right-ventricular-outflow-tract-high-density-endocardial-unipolar-voltage-mapping-in-patients-with-brugada-syndrome-evidence-for-electroanatomical-abnormalities
#3
Konstantinos P Letsas, Michael Efremidis, Konstantinos Vlachos, Stamatis Georgopoulos, Nikolaos Karamichalakis, Dimitrios Asvestas, Kosmas Valkanas, Panagiotis Korantzopoulos, Tong Liu, Antonios Sideris
Aims: Epicardial structural abnormalities at the right ventricular outflow tract (RVOT) may provide the arrhythmia substrate in Brugada syndrome (BrS). Electroanatomical endocardial unipolar voltage mapping is an emerging tool that accurately identifies epicardial abnormalities in different clinical settings. This study investigated whether endocardial unipolar voltage mapping of the RVOT detects electroanatomical abnormalities in patients with BrS. Methods and results: Ten asymptomatic patients (8 males, 34...
May 2, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28472082/efficacy-of-cognitive-behavioral-therapy-in-patients-with-bipolar-disorder-a-meta-analysis-of-randomized-controlled-trials
#4
Kai-Jo Chiang, Jui-Chen Tsai, Doresses Liu, Chueh-Ho Lin, Huei-Ling Chiu, Kuei-Ru Chou
BACKGROUND: Although cognitive behavioral therapy (CBT) is considered a promising adjuvant to pharmacotherapy for treating bipolar disorder (BD), its efficacy is unproven. The present review and meta-analysis evaluated the treatment outcomes of patients with BD treated with CBT plus medication and compared these data with the outcomes of those who received standard care alone. METHODS: Electronic searches from inception to July 31, 2016, were performed using PubMed, Medline OVID, Cochrane Library, EMBASE, CINAHL plus, and PsycINFO...
2017: PloS One
https://www.readbyqxmd.com/read/28466070/a-cre-mouse-line-for-probing-irradiance-and-direction-encoding-retinal-networks
#5
Shai Sabbah, Daniel Berg, Carin Papendorp, Kevin L Briggman, David M Berson
Cell type-specific Cre driver lines have revolutionized the analysis of retinal cell types and circuits. We show that the transgenic mouse Rbp4-Cre selectively labels several retinal neuronal types relevant to the encoding of absolute light intensity (irradiance) and visual motion. In the ganglion cell layer (GCL), most marked cells are wide-field spiking polyaxonal amacrine cells (ACs) with sustained irradiance-encoding ON responses that persist during chemical synaptic blockade. Their arbors spread about 1 mm across the retina and are restricted to the inner half of the ON sublamina of the inner plexiform layer (IPL)...
March 2017: ENeuro
https://www.readbyqxmd.com/read/28458117/risk-of-mood-disorders-in-patients-with-colorectal-cancer
#6
Li-Min Sun, Ji-An Liang, Cheng-Li Lin, Sean Sun, Chia-Hung Kao
BACKGROUND: To assess the risk of mood disorders among patients with colorectal cancer (CRC), a population-based cohort study was performed using the Taiwanese National Health Insurance Research Database. METHODS: The study cohort included 27242 patients diagnosed with CRC between January 1, 2000 and December 31, 2010. Four insurants from the general population without CRC were frequency matched to each case by age, sex, and index year/month to create the control group...
April 25, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28451114/dual-n-type-units-including-pyridine-and-diphenylphosphine-oxide-effective-design-strategy-of-host-materials-for-high-performance-organic-light-emitting-diodes
#7
Wei Li, Jiuyan Li, Di Liu, Deli Li, Dan Zhang
By using pyridine and diphenylphosphine oxide (DPPO) as dual n-type units, two novel bipolar hosts, namely (5-(3,5-di(9H-carbazol-9-yl)phenyl)pyridin-3-yl)diphenylphosphine oxide (m-PyPOmCP), and (6-(3,5-di(9H-carbazol-9-yl)phenyl)pyridin-3-yl)diphenylphosphine oxide (p-PyPOmCP) are developed for blue and green phosphorescent organic light-emitting diodes (PhOLEDs). Direct linking of the dual n-type units not only pulls the LUMOs down, but also keeps the HOMO levels shallow, and leads to high triplet energies (2...
November 1, 2016: Chemical Science
https://www.readbyqxmd.com/read/28437785/the-retina-of-asian-and-african-elephants-comparison-of-newborn-and-adult
#8
Heidrun Kuhrt, Andreas Bringmann, Wolfgang Härtig, Gudrun Wibbelt, Leo Peichl, Andreas Reichenbach
Elephants are precocial mammals that are relatively mature as newborns and mobile shortly after birth. To determine whether the retina of newborn elephants is capable of supporting the mobility of elephant calves, we compared the retinal structures of 2 newborn elephants (1 African and 1 Asian) and 2 adult animals of both species by immunohistochemical and morphometric methods. For the first time, we present here a comprehensive qualitative and quantitative characterization of the cellular composition of the newborn and the adult retinas of 2 elephant species...
2017: Brain, Behavior and Evolution
https://www.readbyqxmd.com/read/28436374/factors-influencing-treatment-of-proximal-femoral-fractures
#9
Sławomir Dudko, Paweł Kosior, Damian Kusz, Anna Wagner, Marcin Kusz, Karolina Godyń
BACKGROUND: Orthopaedics and traumatology departments are dominated by patients with proximal femoral fractures, who represent 20-30% of all patients treated there. The aim of this study was identification and evaluation of factors influencing treatment of proximal femoral fractures. MATERIAL AND METHODS: Between 2008 and 2015, we treated 424 femoral neck fractures and 442 trochanteric fractures in patients over 40 y/o. The impact of fracture location (femoral neck/trochanteric), character (non-displaced/displaced) and the patient's general condition (metrical/biological age, health condition) on qualification and treatment used (fixations/hip pro-sthesis/non-operative) was analyzed...
January 26, 2017: Ortopedia, Traumatologia, Rehabilitacja
https://www.readbyqxmd.com/read/28399092/-the-affective-pathology-in-patients-with-adolescent-bulimia-nervosa
#10
V V Grachev
AIM: To investigate affective pathology in patients with adolescent bulimia nervosa (BN) and to analyze comorbid mutual influences of these clinical entities. MATERIAL AND METHODS: A sample consisted of 52 young female patients, aged from 13.9 to 17.4 years, who simultaneously meet ICD-10 criteria of F50.2 - typical BN and F30-F39 - mood disorders. The Eating Attitudes Test (EAT-26) and the Beck Depression Inventory were used for psychometric assessment. Duration of follow-up ranged from 1 to 7 years...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28397069/licl-treatment-induces-programmed-cell-death-of-schwannoma-cells-through-akt-and-mtor-mediated-necroptosis
#11
Ying Wang, Qi Zhang, Bo Wang, Peng Li, Pinan Liu
Lithium is considered a first-line therapy for the treatment of bipolar disorder and was recently shown to be associated with a reduced overall cancer risk. A growing body of evidence has indicated the potential antitumor benefits of this drug. Lithium likely functions as an antitumor agent. In this study, we found that lithium chloride (LiCl) significantly inhibits the proliferation of both RT4 cells and human NF2-associated primary schwannoma cells by inhibiting the expression of apoptosis-related proteins...
April 10, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28384714/organotypic-cultures-of-adult-mouse-retina-morphologic-changes-and-gene-expression
#12
Brigitte Müller, Franziska Wagner, Birgit Lorenz, Knut Stieger
Purpose: The purpose of this study was characterization of adult murine neuroretina in organ culture to investigate its suitability for use in preclinical therapeutic applications. In retinal disorders, neurodegeneration of mature retinal cells takes place. Therefore, neonatal retina cultures are not adequate for therapeutic applications, such as genome editing, as the retina is still developing with cells dividing and differentiating into highly specialized cell types such as photoreceptors...
April 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28365865/socio-demographic-and-clinical-characterization-of-patients-with-bipolar-disorder-i-vs-ii-a-nationwide-italian-study
#13
A Carlo Altamura, Massimiliano Buoli, Bruno Cesana, Bernardo Dell'Osso, Gianluigi Tacchini, Umberto Albert, Andrea Fagiolini, Andrea de Bartolomeis, Giuseppe Maina, Emilio Sacchetti
Bipolar disorders (BDs) are prevalent, comorbid and disabling conditions, associated with the highest suicide risk among psychiatric illnesses. In the last few years, new efforts to better characterize the socio-demographic and clinical profiles of BD type I vs II have been documented by several reports, with novel and insightful findings in the field. The present multicenter study aimed to provide a comprehensive and reliable representation of the Italian reality, through the analysis of the largest national sample of bipolar patients collected so far...
April 1, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28360522/long-term-efficacy-and-safety-of-lamotrigine-for-all-types-of-bipolar-disorder
#14
Yoshinori Watanabe, Seiji Hongo
BACKGROUND: We investigated whether the long-term efficacy and safety of lamotrigine (LTG) for bipolar disorder (BP) differs between disease types (BP-I, BP-II, or BP not otherwise specified [BP-NOS]), and the efficacy of the concomitant use of antidepressants (ADs). METHODS: For >1 year, we observed 445 outpatients with BP (diagnosed by DSM-IV criteria) who initiated LTG treatment between July 1 and October 31, 2011, using the Himorogi Self-rating Depression (HSDS) and Anxiety Scales and the Clinical Global Impression-Improvement scale and also recorded adverse events...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28341269/ultrasonic-bipolar-and-integrated-energy-devices-comparing-heat-spread-in-collateral-tissues
#15
Megan K Applewhite, Michael G White, Benjamin C James, Layth Abdulrasool, Edwin L Kaplan, Peter Angelos, Raymon H Grogan
BACKGROUND: Integrated devices incorporating ultrasonic and bipolar technology have been used in laparoscopic surgery, however, are not yet incorporated into open operations. Here, we compare thermal spread and recurrent laryngeal nerve (RLN) functional data of the integrated THUNDERBEAT Open Fine Jaw device, the bipolar Ligasure Small Jaw, and the ultrasonic Harmonic Focus for open thyroidectomy. MATERIALS AND METHODS: The three energy devices were compared in a live porcine model using three tissue types including liver, muscle, and thyroid...
January 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28323174/multicenter-investigation-of-an-implantable-cardioverter-defibrillator-algorithm-to-detect-oversensing
#16
Nicolas Welte, Marc Strik, Romain Eschalier, Pierre Mondoly, Pascal Defaye, Antonio Frontera, Philippe Ritter, Michel Haïssaguerre, Sylvain Ploux, Jayanthi Koneru, Kenneth A Ellenbogen, Pierre Bordachar
BACKGROUND: The SecureSense right ventricular (RV) lead noise discrimination algorithm is designed to detect lead fracture and other types of oversensing in order to decrease inappropriate therapy. OBJECTIVE: We studied the real-life accuracy of the SecureSense algorithm in implantable cardioverter-defibrillator (ICD) patients followed by remote monitoring across multiple centers. METHODS: Across 3 French centers, we studied 486 patients with a St Jude Medical device who were followed by remote monitoring and who had the SecureSense algorithm activated...
March 18, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28316962/wiring-techniques-for-the-fixation-of-trochanteric-fragments-during-bipolar-hemiarthroplasty-for-femoral-intertrochanteric-fracture-clinical-study-and-technical-note
#17
Joong-Myung Lee, Yongsuk Cho, Junhyun Kim, Dong-Won Kim
PURPOSE: Femoral intertrochanteric fractures are common in the elderly. Appropriate surgical fixation of trochanteric fracture fragments can restore normal anatomical structure and ambulation, and can aid in the recovery of biomechanical function of the hip. We evaluated clinical outcomes of bipolar hemiarthroplasty using a wiring technique for trochanteric fracture fragment fixation. MATERIALS AND METHODS: From September 2006 to February 2015, a total of 260 cases underwent simultaneous bipolar hemiarthroplasty and wire fixation...
March 2017: Hip & Pelvis
https://www.readbyqxmd.com/read/28316877/progression-of-pro23his-retinopathy-in-a-miniature-swine-model-of-retinitis-pigmentosa
#18
Patrick A Scott, Juan P Fernandez de Castro, Paul J DeMarco, Jason W Ross, Josephat Njoka, Eric Walters, Randall S Prather, Maureen A McCall, Henry J Kaplan
PURPOSE: We characterize the progression of retinopathy in Filial 1 (F1) progeny of a transgenic (Tg) founder miniswine exhibiting severe Pro23His (P23H) retinopathy. METHODS: The F1 TgP23H miniswine progeny were created by crossing TgP23H founder miniswine 53-1 with wild type (WT) inbred miniature swine. Scotopic (rod-driven) and photopic (cone-driven) retinal functions were evaluated in F1 TgP23H and WT littermates using full field electroretinograms (ffERGs) at 1, 2, 3, 6, 9, 12, and 18 months of age, as well as the Tg founder miniswine at 6 years of age...
March 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/28315278/peeking-into-sigma-1-receptor-functions-through-the-retina
#19
Timur A Mavlyutov, Lian-Wang Guo
This review discusses recent advances towards understanding the sigma-1 receptor (S1R) as an endogenous neuro-protective mechanism in the retina , a favorable experimental model system. The exquisite architecture of the mammalian retina features layered and intricately wired neurons supported by non-neuronal cells. Ganglion neurons, photoreceptors , as well as the retinal pigment epithelium, are susceptible to degeneration that leads to major retinal diseases such as glaucoma , diabetic retinopathy , and age-related macular degeneration (AMD), and ultimately, blindness...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28280345/screening-for-bipolar-disorder-among-migraineurs-the-impact-of-migraine-bipolar-disorder-comorbidity-on-disease-characteristics
#20
Yigit Kivilcim, Merih Altintas, Fusun Mayda Domac, Erkal Erzincan, Huseyin Gülec
PURPOSE: The aim of this study was to evaluate the prevalence of comorbid bipolar disorder (BD) among migraineurs and the impact of migraine-BD comorbidity on disease characteristics. PATIENTS AND METHODS: A total of 120 adult patients diagnosed with migraine at a single tertiary care center were included in this cross-sectional study. Data on sociodemographic and migraine-related characteristics, family history of psychiatric diseases, comorbid psychiatric diseases, and first-episode characteristics were recorded...
2017: Neuropsychiatric Disease and Treatment
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