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https://www.readbyqxmd.com/read/29125183/ovarian-surgery-for-symptom-relief-in-women-with-polycystic-ovary-syndrome
#1
REVIEW
Sam Lepine, Junyoung Jo, Mostafa Metwally, Ying C Cheong
BACKGROUND: Polycystic ovary syndrome (PCOS) is a common endocrine condition, affecting approximately one in 10 women. PCOS is defined by two of three features: oligo- or anovulation, clinical or biochemical hyperandrogenism or both, or polycystic ovaries.Women with PCOS can have a wide range of health problems, including infrequent and irregular periods, unwanted hair growth and acne, and subnormal fertility. Long-term health concerns include an increased risk of heart disease, diabetes and the development of precancerous disease of the womb...
November 10, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29119926/-the-role-of-cxcr3-in-neurological-diseases
#2
Ya-Qun Zhou, Dai-Qiang Liu, Shu-Ping Chen, Jia Sun, Xue-Rong Zhou, Cui Xing, Da-Wei Ye, Yu-Ke Tian
Neurological diseases have become an obvious challenge due to insufficient therapeutic intervention. Therefore, novel drugs for various neurological disorders are in desperate need. Recently, compelling evidence has demonstrated that chemokine receptor CXCR3, which is a G protein-coupled receptor in the CXC chemokine receptor family, may play a pivotal role in the development of neurological diseases. The expression level of CXCR3 in T cells was significantly elevated in several neurological diseases, suggesting a potential therapeutic role of CXCR3 antagonists...
November 9, 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/29115833/chemical-design-and-example-of-transparent-bipolar-semiconductors
#3
Takeshi Arai, Soshi Iimura, Junghwan Kim, Yoshitake Toda, Shigenori Ueda, Hideo Hosono
Transparent bipolar semiconductors (TBSCs) are in demand for transparent electronics to serve as the basis for next generation optoelectronic devices. However, the poor carrier controllability in wide-bandgap materials makes the realization of a bipolar nature difficult. Only two materials, CuInO2 and SnO, have been reported as TBSCs. To satisfy demand for the coexistence of transparency and bipolarity, we propose a design concept with three strategies; choice of early transition metals (eTM) such as Y(3+) and Zr(4+) for improving controllability of carrier doping, design of chemical bonds to obtain an appropriate band structure for bipolar doping, and use of a forbidden band-edge transition to retain transparency...
November 17, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29109669/mental-illness-related-internalized-stigma-psychometric-properties-of-the-brief-ismi-scale-in-greece
#4
Alexia Paraskevoulakou, Kassiani Vrettou, Katerina Pikouli, Evgenia Triantafillou, Anastasia Lykou, Marina Economou
Aims: Since evaluation regarding the impact of mental illness related internalized stigma is scarce, there is a great need for psychometric instruments which could contribute to understanding its adverse effects among Greek patients with severe mental illness. The Brief Internalized Stigma of Mental Illness (ISMI) scale is one of the most widely used measures designed to assess the subjective experience of stigma related to mental illness. The present study aimed to investigate the psychometric properties of the Greek version of the Brief ISMI scale...
September 2017: Materia Socio-medica
https://www.readbyqxmd.com/read/29071281/evaluation-of-vntr-polymorphisms-of-dopamine-transporter-gene-and-the-risk-of-bipolar-disorder-in-zahedan-southeast-iran
#5
Mansour Shakiba, Mohammad Hashemi, Salah Mahdar, Zahra Rahbari, Gholamreza Bahari
The exact role of dopamine transporter gene (DAT1) in the pathogenesis of bipolar disorder type 1 (BD) is not understood. In the present study, we aimed to evaluate the possible association between 30, 40 and 63 bp variable number tandem repeat (VNTR) polymorphisms of DAT1 gene and the risk of type 1 (BD) in a sample of Iranian population. This case-control study was performed on 152 BD patients and 153 psychiatrically healthy subjects. Genotyping of the variant was done by polymerase chain reaction method...
September 2017: Molecular Biology Research Communications
https://www.readbyqxmd.com/read/29063217/quetiapine-induced-hypomania-and-its-association-with-quetiapine-norquetiapine-plasma-concentrations-a-case-series-of-bipolar-type-2-patients
#6
C Rovera, C M Esposito, V Ciappolino, D Cattaneo, S Baldelli, E Clementi, A C Altamura, M Buoli
International guidelines consider quetiapine at medium doses (300-400 mg/day) as valid options for the treatment of bipolar depression for the supposed lower risk of a switch to hypomania/mania than antidepressants. Norquetiapine is an active metabolite with antidepressant action. We describe three cases of induced hypomania in bipolar type 2 subjects who received quetiapine extended-release monotherapy (300 mg/day) for a mild/moderate major depressive episode. Quetiapine and norquetiapine plasma concentrations were measured after 1 week of treatment...
October 23, 2017: Drug Safety—Case Reports
https://www.readbyqxmd.com/read/29062369/evaluation-of-bipolar-disorder-in-several-relapses-over-time-using-generalized-estimating-equations
#7
Payam Amini, Roya Najafi-Vosough, Ali Ghaleiha, Hossein Mahjub
Objective: Bipolar disorder is defined as a common and severe chronic disorder that causes several problems in a person's psychosocial functioning. This study aimed at modeling the development of bipolar disorder episodes using its determinant risk factors over time. Method: This retrospective cohort study was conducted in Hamadan province, the West of Iran, from April 2008 to September 2014. In this study, 124 patients with bipolar disorder (both Type I and Type II) participated. All patients had experienced 4 relapses...
July 2017: Iranian Journal of Psychiatry
https://www.readbyqxmd.com/read/29061151/comparison-of-health-related-quality-of-life-among-men-with-different-co-existing-severe-mental-disorders-in-treatment-for-substance-use
#8
Ana Adan, Julia E Marquez-Arrico, Gail Gilchrist
BACKGROUND: Patient-perceived health-related quality of life has become an important outcome in health care as an indicator of treatment effectiveness and recovery for patients with substance use disorder. As no study has assessed health-related quality of life among male patients with substance use disorder and co-existing severe mental illness, we compared health-related quality of life among patients with substance use disorder and the following severe mental illness diagnosis in Barcelona, Spain: schizophrenia, bipolar disorder, major depressive disorder, and examined the associations with clinically related variables...
October 23, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/29058350/synthesis-of-large-size-1t-res2x-se2-1-x-alloy-monolayer-with-tunable-bandgap-and-carrier-type
#9
Fangfang Cui, Qingliang Feng, Jinhua Hong, Renyan Wang, Yu Bai, Xiaobo Li, Dongyan Liu, Yu Zhou, Xing Liang, Xuexia He, Zhongyue Zhang, Shengzhong Liu, Zhibin Lei, Zonghuai Liu, Tianyou Zhai, Hua Xu
Chemical vapor deposition growth of 1T' ReS2x Se2(1-x) alloy monolayers is reported for the first time. The composition and the corresponding bandgap of the alloy can be continuously tuned from ReSe2 (1.32 eV) to ReS2 (1.62 eV) by precisely controlling the growth conditions. Atomic-resolution scanning transmission electron microscopy reveals an interesting local atomic distribution in ReS2x Se2(1-x) alloy, where S and Se atoms are selectively occupied at different X sites in each Re-X6 octahedral unit cell with perfect matching between their atomic radius and space size of each X site...
October 23, 2017: Advanced Materials
https://www.readbyqxmd.com/read/29054353/the-rate-of-radial-head-prosthesis-removal-or-revision-a-systematic-review-and-meta-analysis
#10
Amir R Kachooei, Aslan Baradaran, Mohammad H Ebrahimzadeh, C Niek van Dijk, Neal Chen
PURPOSE: We conducted a meta-analysis and systematic review with the primary objective to determine the overall incidence of radial head prosthesis removal or revision. Our secondary objectives addressed the incidence of removal or revision based on the type of prosthesis fixation (cemented, uncemented smooth stem, uncemented press-fit), material (metal, Vitallium, titanium, pyrocarbon), and design (short vs long stem and monopolar vs bipolar), and the reasons for prosthetic removal or revision...
October 18, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29037595/cellular-characterization-of-optical-coherence-tomography-and-outer-retinal-bands-using-specific-immunohistochemistry-markers-and-clinical-implications
#11
Nicolás Cuenca, Isabel Ortuño-Lizarán, Isabel Pinilla
PURPOSE: Optical coherence tomography has been a technological breakthrough in the diagnosis, treatment, and follow-up of many ocular diseases, especially retinal and neuro-ophthalmologic pathologic conditions. Until now, several controversies have arisen over the specific cell types that the bands observed in the OCT represent, especially over the 4 outer retinal bands. DESIGN: To correlate the 4 outer hyperreflective bands observed in the OCT with the histologic structures using human retinal sections and immunocytochemistry at the fovea level...
October 13, 2017: Ophthalmology
https://www.readbyqxmd.com/read/29021925/acetazolamide-treatment-of-psychogenic-polydipsia
#12
Syed E Ahmed, Afaque H Khan
We are reporting a case of psychogenic polydipsia from a State of Ohio psychiatric hospital. The patient has a known five-year history of psychogenic polydipsia with recurrent hyponatremia and has been diagnosed with schizoaffective disorder bipolar type 1, according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria, for the past two decades. There was a marked improvement with the use of acetazolamide, resulting in a decreased compulsion to drink fluid and improvement of his hyponatremia...
August 9, 2017: Curēus
https://www.readbyqxmd.com/read/29017329/modulation-of-n-type-units-in-bipolar-host-materials-toward-high-performance-phosphorescent-oleds
#13
Fang Wang, Di Liu, Jiuyan Li, Mengyao Ma
9'-Pyridinyl-9'H-9,3':6',9″-tercarbazole (PyCz) is a bipolar host material in phosphorescent organic light-emitting diodes (PhOLEDs). A second n-type unit, either pyridine or diphenylphosphine dioxide (DPPO), is introduced onto the pyridine ring of PyCz at para- or metasite to design and prepare four novel "dual n-type unit bipolar host" materials m-BPyCz, p-BPyCz, m-POPyCz, and p-POPyCz. The incorporation of the second n-type unit pulls down the lowest unoccupied molecular orbitals and facilitates electron injection and transportation, resulting in better charge-balancing ability...
October 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28987077/remission-of-schizoaffective-disorder-using-homeopathic-medicine-2-case-reports
#14
Diane E Grise, Tara Peyman, Jeffrey Langland
Context • Research on the schizophrenia spectrum is primarily focused on pharmaceutical interventions, although alternative treatments have been gaining increasing popularity in recent years because patients are seeking treatments that are effective and have reduced side effects. A significant body of evidence already exists supporting the effectiveness of homeopathy to treat a wide array of illnesses. Objective • The research team intended to demonstrate the need for using both alternative and conventional treatments to improve clinical outcomes in the treatment of schizoaffective disorder...
October 2, 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/28977070/cardiovascular-risk-and-bipolar-disorder-factors-associated-with-a-positive-coronary-calcium-score-in-patients-with-bipolar-disorder-type-1
#15
Aline R Wageck, Felipe S Torres, Clarissa S Gama, Dayane S Martins, Ellen Scotton, Ramiro Reckziegel, Monise Costanzi, Regis G Rosa, Flávio Kapczinski, Maurício Kunz
OBJECTIVE: Cardiovascular disease is the leading cause of death in patients with bipolar disorder. The aim of this study was to evaluate the factors associated with positive coronary calcium score (CCS) in individuals with bipolar disorder type 1. METHODS: Patients from the Bipolar Disorder Program at Hospital de Clínicas de Porto Alegre, Brazil, underwent computed tomography scanning for calcium score measurement. Clinical and sociodemographic variables were compared between patients according to their CCS status: negative (CCS = 0) or positive (CCS > 0)...
October 2, 2017: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/28972930/insomnia-and-hypersomnia-in-major-depressive-episode-prevalence-sociodemographic-characteristics-and-psychiatric-comorbidity-in-a-population-based-study
#16
Pierre A Geoffroy, Nicolas Hoertel, Bruno Etain, Frank Bellivier, Richard Delorme, Frédéric Limosin, Hugo Peyre
OBJECTIVES: To examine (i) the frequency of different sleep complaints (early wake-up, trouble falling asleep, hypersomnia) and their co-occurrence and (ii) the sociodemographic characteristics and psychiatric comorbidity associated with each type of sleep profiles. METHODS: Data were drawn from the Wave 2 National Epidemiologic Survey on Alcohol and Related Conditions, a nationally representative survey of the US adult population (wave 1, 2001-2002; wave 2, 2004-2005)...
September 25, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28968513/prevalences-of-autoimmune-diseases-in-schizophrenia-bipolar-i-and-ii-disorder-and-controls
#17
Laura Cremaschi, Mathias Kardell, Viktoria Johansson, Anniella Isgren, Carl M Sellgren, A Carlo Altamura, Christina M Hultman, Mikael Landén
Previous studies on the relationship between autoimmune diseases, schizophrenia, and bipolar disorder are mainly based on hospital discharge registers with insufficient coverage of outpatient data. Furthermore, data is scant on the prevalence of autoimmune diseases in bipolar subgroups. Here we estimate the self-reported prevalences of autoimmune diseases in schizophrenia, bipolar disorder type I and II, and controls. Lifetime prevalence of autoimmune diseases was assessed through a structured interview in a sample of 9076 patients (schizophrenia N = 5278, bipolar disorder type I N = 1952, type II N = 1846) and 6485 controls...
December 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28966902/mental-health-in-allergic-rhinitis-depression-and-suicidal-behavior
#18
Ameya U Amritwar, Christopher A Lowry, Lisa A Brenner, Andrew J Hoisington, Robert Hamilton, John W Stiller, Teodor T Postolache
A high proportion of suicides visit their medical provider in the month prior to death, but depression, suicidal thoughts, and substance use are seldom addressed. For the clinicians routinely treating a substantial patient population with allergic diseases, there are additional concerns, as allergy has been linked with both depression and suicidal behavior. While psychotropic medications may affect diagnosis of allergies, medications used to treat allergies impact mood and behavior. Thus, we present an overview of the overlap of allergic rhinitis with depression and suicidal behavior in adults, based on clinical and epidemiological data, and our research and clinical experience...
March 2017: Current Treatment Options in Allergy
https://www.readbyqxmd.com/read/28966598/verbal-memory-impairment-in-patients-with-subsyndromal-bipolar-disorder
#19
Tomiki Sumiyoshi, Atsuhito Toyomaki, Naoko Kawano, Tomoko Kitajima, Ichiro Kusumi, Norio Ozaki, Nakao Iwata, Kazuki Sueyoshi, Kazuyuki Nakagome
BACKGROUNDS: Several domains of cognitive function, including learning memory and executive function, are impaired in mood disorders. Also, the relationship between disturbances of these two cognitive domains has been suggested. In line with the recent initiative to establish a standard measure of cognitive decline in bipolar disorder, the present study was conducted to (1) test the criterion-related validity and test-retest reliability of the California Verbal Learning Test (CVLT)-II Japanese version, and (2) determine if type of word learning tasks (i...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28950781/blockade-of-dopamine-d1-family-receptors-attenuates-the-mania-like-hyperactive-risk-preferring-and-high-motivation-behavioral-profile-of-mice-with-low-dopamine-transporter-levels
#20
Morgane Milienne-Petiot, Lucianne Groenink, Arpi Minassian, Jared W Young
BACKGROUND: Patients with bipolar disorder mania exhibit poor cognition, impulsivity, risk-taking, and goal-directed activity that negatively impact their quality of life. To date, existing treatments for bipolar disorder do not adequately remediate cognitive dysfunction. Reducing dopamine transporter expression recreates many bipolar disorder mania-relevant behaviors (i.e. hyperactivity and risk-taking). The current study investigated whether dopamine D1-family receptor blockade would attenuate the risk-taking, hypermotivation, and hyperactivity of dopamine transporter knockdown mice...
October 2017: Journal of Psychopharmacology
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