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bipolar type 1

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https://www.readbyqxmd.com/read/29776917/treatment-refractory-mania-with-psychosis-in-a-post-transplant-patient-on-tacrolimus-a-case-report
#1
Muaid Ithman, Kunal Malhotra, Meelie Bordoloi, Garima Singh
Bipolar affective disorder type I imparts significant morbidity and disease burden in the Population. It is characterized by occurrence of one or more manic episodes which may be preceded or followed by a depressive or hypomanic phase. About half of these manic episodes are characterized by the presence of psychotic features [1]. The condition is further complicated when patient has multiple comorbid conditions. We report here a case of a 66 year old Caucasian female, previously diagnosed with Bipolar disorder who developed treatment refractory mania with psychotic feature after being on Tacrolimus (an immunosuppressive agent) after kidney transplantation...
May 18, 2018: Clinical Medicine & Research
https://www.readbyqxmd.com/read/29770880/intraoperative-periprosthetic-femur-fracture-during-bipolar-hemiarthroplasty-for-displaced-femoral-neck-fractures
#2
Choon Chiet Hong, Nazrul Nashi, Jiong Hao Tan, Ruben Manohara, Wei Ting Lee, Diarmuid Paul Murphy
INTRODUCTION: We aim to review the incidence and risk factors for the development of intraoperative periprosthetic femur fractures while performing a bipolar hemiarthroplasty for displaced neck of femur fractures. Our secondary aim is to characterize the types of intraoperative periprosthetic fractures, the steps leading to the fractures, and the salvage treatments instituted. MATERIALS AND METHODS: 271 patients treated with bipolar hemiarthroplasty after traumatic displaced femoral neck fractures were retrospectively analyzed...
May 17, 2018: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29741202/identification-of-protein-kinase-c-%C3%AE-and-tyrosine-hydroxylase-immunoreactive-cells-in-the-microbat-retina
#3
Eun-Bee Park, Joo-Yeong Jeon, Chang-Jin Jeon
A growing number of studies have revealed the functional neuroarchitecture of the microbat retina and suggested that microbats can see using their eyes. To better understand the organization of the microbat retina, quantitative analysis of protein kinase C alpha (PKCα)- and tyrosine hydroxylase (TH)-immunoreactive (IR) cells was conducted on the greater horseshoe bat (Rhinolophus ferrumequinum) retina. As a result, PKCα immunoreactivity was observed in rod bipolar cells, consistent with previous studies on other mammalian retinas...
May 9, 2018: Histology and Histopathology
https://www.readbyqxmd.com/read/29739870/pregnancy-associated-plasma-protein-aa-pappaa-regulates-photoreceptor-synaptic-development-to-mediate-visually-guided-behavior
#4
Andrew H Miller, Hollis B Howe, Bryan M Krause, Scott A Friedle, Matthew I Banks, Brian D Perkins, Marc A Wolman
To guide behavior, sensory systems detect the onset and offset of stimuli and process these distinct inputs via parallel pathways. In the retina, this strategy is implemented by splitting neural signals for light onset and offset via synapses connecting photoreceptors to ON and OFF bipolar cells, respectively. It remains poorly understood which molecular cues establish the architecture of this synaptic configuration to split light onset and offset signals. A mutant with reduced synapses between photoreceptors and one bipolar cell type, but not the other, could reveal a critical cue...
May 8, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29730937/familiality-of-psychiatric-disorders-and-risk-of-postpartum-psychiatric-episodes-a-population-based-cohort-study
#5
Anna E Bauer, Merete L Maegbaek, Xiaoqin Liu, Naomi R Wray, Patrick F Sullivan, William C Miller, Samantha Meltzer-Brody, Trine Munk-Olsen
OBJECTIVE: Postpartum psychiatric disorders are common and morbid complications of pregnancy. The authors sought to evaluate how family history of psychiatric disorders is associated with postpartum psychiatric disorders in proband mothers with and without a prior psychiatric history by assessing degree of relationship, type of disorder, and sex of family members. METHOD: The authors linked Danish birth and psychiatric treatment registers to evaluate familial risk of postpartum psychiatric episodes in a national population-based cohort...
May 7, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29710135/association-between-muscular-strength-and-cognition-in-people-with-major-depression-or-bipolar-disorder-and-healthy-controls
#6
Joseph Firth, Josh A Firth, Brendon Stubbs, Davy Vancampfort, Felipe B Schuch, Mats Hallgren, Nicola Veronese, Alison R Yung, Jerome Sarris
Importance: Objective physical fitness measures, such as handgrip strength, are associated with physical, mental, and cognitive outcomes in the general population. Although people with mental illness experience reduced physical fitness and cognitive impairment, the association between muscular strength and cognition has not been examined to date. Objective: To determine associations between maximal handgrip strength and cognitive performance in people with major depression or bipolar disorder and in healthy controls...
April 18, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/29708262/bipolar-magnetic-semiconductors-among-intermediate-states-during-the-conversion-from-sc-2-c-oh-2-to-sc-2-co-2-mxene
#7
Xian-Hu Zha, Ji-Chang Ren, Li Feng, Xiaojing Bai, Kan Luo, Yaqing Zhang, Jian He, Qing Huang, Joseph S Francisco, Shiyu Du
MXenes represent a new family of two-dimensional materials that have attracted considerable attention in recent years. Because of the remarkably different structures of Sc2C(OH)2 and Sc2CO2 MXene and their recently reported properties, this study explored the structural evolution and mechanism of chemical conversion between these two MXenes. Using first-principles density functional theory (DFT), the mechanism for dehydrogenation/hydrogenation is investigated by gradually removing/adding surface hydrogen atoms for Sc2C(OH)2/Sc2CO2 supercells...
April 30, 2018: Nanoscale
https://www.readbyqxmd.com/read/29691917/an-immunological-age-index-in-bipolar-disorder-a-confirmatory-factor-analysis-of-putative-immunosenescence-markers-and-associations-with-clinical-characteristics
#8
Lucas B Rizzo, Walter Swardfager, Pawan Kumar Maurya, Maiara Zeni Graiff, Mariana Pedrini, Elson Asevedo, Ana Cláudia Cassinelli, Moisés E Bauer, Quirino Cordeiro, Jan Scott, Elisa Brietzke, Hugo Cogo-Moreira
OBJECTIVES: The study aims to generate an immunological age (IA) trait on the basis of immune cell differentiation parameters, and to test whether the IA is related to age and disease characteristics. METHODS: Forty-four euthymic type I bipolar disorder patients were included in this study. Five immunosenescence-related parameters were assessed: proportions of late-differentiated cells (e.g., CD3+CD8+CD28-CD27- and CD3-CD19+IgD-CD27-), and the expression of CD69, CD71, and CD152 after stimulation...
April 25, 2018: International Journal of Methods in Psychiatric Research
https://www.readbyqxmd.com/read/29651610/periprosthetic-femoral-fracture-as-cause-of-early-revision-after-short-stem-hip-arthroplasty-a-multicentric-analysis
#9
Sang-Min Kim, Seung-Beom Han, Kee Hyung Rhyu, Jeong Joon Yoo, Kwang-Jun Oh, Je Hyun Yoo, Kyung-Jae Lee, Seung-Jae Lim
BACKGROUND: The objective of this study was to analyze the prevalence and causes of early re-operation after hip replacement surgery using short bone-preserving stems in a large multicentre series. Specifically, we evaluated the clinical features of periprosthetic fractures occurring around short stems. METHODS: A total of 897 patients (1089 hips) who underwent primary total hip arthroplasty or bipolar hemiarthroplasty from January 2011 to February 2015 using short bone-preserving femoral stems were recruited...
April 12, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29627664/the-second-phase-of-bipolar-nanosecond-range-electric-pulses-determines-the-electroporation-efficiency
#10
Andrei G Pakhomov, Sergey Grigoryev, Iurii Semenov, Maura Casciola, Chunqi Jiang, Shu Xiao
Bipolar cancellation refers to a phenomenon when applying a second electric pulse reduces ("cancels") cell membrane damage by a preceding electric pulse of the opposite polarity. Bipolar cancellation is a reason why bipolar nanosecond electric pulses (nsEP) cause weaker electroporation than just a single unipolar phase of the same pulse. This study was undertaken to explore the dependence of bipolar cancellation on nsEP parameters, with emphasis on the amplitude ratio of two opposite polarity phases of a bipolar pulse...
March 29, 2018: Bioelectrochemistry
https://www.readbyqxmd.com/read/29625762/effectiveness-of-preventive-cognitive-therapy-while-tapering-antidepressants-versus-maintenance-antidepressant-treatment-versus-their-combination-in-prevention-of-depressive-relapse-or-recurrence-drd-study-a-three-group-multicentre-randomised-controlled-trial
#11
Claudi L H Bockting, Nicola S Klein, Hermien J Elgersma, Gerard D van Rijsbergen, Christien Slofstra, Johan Ormel, Erik Buskens, Jack Dekker, Peter J de Jong, Willem A Nolen, Aart H Schene, Steven D Hollon, Huibert Burger
BACKGROUND: Keeping individuals on antidepressants after remission or recovery of major depressive disorder is a common strategy to prevent relapse or recurrence. Preventive cognitive therapy (PCT) has been proposed as an alternative to maintenance antidepressant treatment, but whether its addition would allow tapering of antidepressants or enhance the efficacy of maintenance antidepressant treatment is unclear. We aimed to compare the effectiveness of antidepressants alone, with PCT while tapering off antidepressants, or PCT added to antidepressants in the prevention of relapse and recurrence...
April 3, 2018: Lancet Psychiatry
https://www.readbyqxmd.com/read/29625538/hospitalization-risk-in-bipolar-disorder-patients-treated-with-lurasidone-versus-other-atypical-antipsychotics
#12
Daisy Ng-Mak, Rachel Halpern, Krithika Rajagopalan, Antony Loebel
OBJECTIVE: This observational study compared the risk of hospitalization for patients with bipolar disorder when treated with lurasidone versus other oral atypical antipsychotics. METHODS: This U.S. commercial claims analysis (April 4, 2010 through September 24, 2014) used the Optum Research Database to identify adult patients with bipolar disorder treated with oral atypical antipsychotics (N = 11,132). The first claim for an atypical antipsychotic defined the index date, with pre-index and post-index periods of 180 and 360 days, respectively...
April 6, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29620693/longer-term-effectiveness-and-tolerability-of-adjunctive-open-lurasidone-in-patients-with-bipolar-disorder
#13
Shefali Miller, Dennis Do, Anda Gershon, Po W Wang, Farnaz Hooshmand, Lauren S Chang, Terence A Ketter
PURPOSE: To retrospectively assess lurasidone effectiveness/efficacy/tolerability in bipolar disorder (BD) patients. METHODS: Outpatients assessed with Systematic Treatment Enhancement Program for BD Affective Disorders Evaluation received naturalistically administered (primarily adjunctive) open lurasidone while monitored at visits with the Systematic Treatment Enhancement Program for BD Clinical Monitoring Form. RESULTS: Sixty-one patients (32 type I, 26 type II, 3 type not otherwise specified; mean ± SD age, 45...
June 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29620518/examining-cognition-across-the-bipolar-schizophrenia-diagnostic-spectrum
#14
Amy J Lynham, Leon Hubbard, Katherine E Tansey, Marian L Hamshere, Sophie E Legge, Michael J Owen, Ian R Jones, James T R Walters
BACKGROUND: Cognitive impairments are well-established features of schizophrenia, but there is ongoing debate about the nature and degree of cognitive impairment in patients with schizoaffective disorder and bipolar disorder. We hypothesized that there is a spectrum of increasing impairment from bipolar disorder to schizoaffective disorder bipolar type, to schizoaffective disorder depressive type and schizophrenia. METHODS: We compared performance on the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Consensus Cognitive Battery between participants with schizophrenia ( n = 558), schizoaffective disorder depressive type ( n = 112), schizoaffective disorder type ( n = 76), bipolar disorder ( n = 78) and healthy participants ( n = 103) using analysis of covariance with post hoc comparisons...
April 5, 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/29615095/loss-of-xbp1-accelerates-age-related-decline-in-retinal-function-and-neurodegeneration
#15
Todd McLaughlin, Marek Falkowski, Jae Whan Park, Stephen Keegan, Michael Elliott, Joshua J Wang, Sarah X Zhang
BACKGROUND: Aging is the strongest risk factor for neurodegenerative diseases and extended age results in neuronal degeneration and functional decline in the visual system. Among many contributing factors to age-related deterioration of neurons is an insufficient activation of the Unfolded Protein Response (UPR) in the endoplasmic reticulum (ER) in response to cellular stress. X-box binding protein 1 (XBP1) is a major component of the UPR and is essential for maintaining protein homeostasis and reducing cellular stresses...
April 4, 2018: Molecular Neurodegeneration
https://www.readbyqxmd.com/read/29606887/electrical-peripheral-nerve-stimulation-relieves-bone-cancer-pain-by-inducing-arc-protein-expression-in-the-spinal-cord-dorsal-horn
#16
Ke-Fu Sun, Wan-Wen Feng, Yue-Peng Liu, Yan-Bin Dong, Li Gao, Hui-Lin Yang
Objective: The analgesic effect on chronic pain of peripheral nerve stimulation (PNS) has been proven, but its underlying mechanism remains unknown. Therefore, this study aimed to assess the analgesic effect of PNS on bone cancer pain in a rat model and to explore the underlying mechanism. Materials and methods: PNS on sciatic nerves with bipolar electrode was performed in both naïve and bone cancer pain model rats. Then, the protein levels of activity-regulated cytoskeleton-associated protein (Arc), α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptor 1 (GluA1), and phosphate N -methyl-d-aspartic acid-type glutamate receptor subunit 2B (pGluNR2B) in spinal cord were evaluated by immunohistochemistry and Western blotting...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29578271/psychoeducation-for-psychiatric-inpatients-following-remission-of-a-manic-episode-in-bipolar-i-disorder-a-randomized-controlled-trial
#17
Runsen Chen, Xuequan Zhu, Liliana P Capitão, Huijun Zhang, Jiong Luo, Xue Wang, Yingjun Xi, Xiuping Song, Yancun Feng, Liuzhong Cao, Gin S Malhi
OBJECTIVE: The aim of the present study was to evaluate the effectiveness of psychoeducation for bipolar I inpatients following remission of a manic episode in a Chinese population. METHOD: The study recruited currently medicated bipolar I patients, aged 18-60 years, who were in remission from a manic episode, as determined using the Diagnostic and Statistical Manual of Mental Disorders Fifth Edition (DSM-5). Patients were randomized (1:1) to either eight sessions of group-based psychoeducation (active treatment group) or regular free discussions (control group)...
March 26, 2018: Bipolar Disorders
https://www.readbyqxmd.com/read/29574260/hla-typing-using-genome-wide-data-reveals-susceptibility-types-for-infections-in-a-psychiatric-disease-enriched-sample
#18
Samuel Parks, Dimitrios Avramopoulos, Jennifer Mulle, John McGrath, Ruihua Wang, Fernando S Goes, Karen Conneely, Ingo Ruczinski, Robert Yolken, Ann E Pulver, Brad D Pearce
BACKGROUND: The infections Toxoplasma gondii (T. gondii), cytomegalovirus, and Herpes Simplex Virus Type 1 (HSV1) are common persistent infections that have been associated with schizophrenia and bipolar disorder. The major histocompatibility complex (MHC, termed HLA in humans) region has been implicated in these infections and these mental illnesses. The interplay of MHC genetics, mental illness, and infection has not been systematically examined in previous research. METHODS: In a cohort of 1636 individuals, we used genome-wide association data to impute 7 HLA types (A, B, C, DRB1, DQA1, DQB1, DPB1), and combined this data with serology data for these infections...
March 21, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29572434/convergence-and-divergence-of-crh-amacrine-cells-in-mouse-retinal-circuitry
#19
Silvia J H Park, Joseph Pottackal, Jiang-Bin Ke, Na Young Jun, Pouyan Rahmani, In-Jung Kim, Joshua H Singer, Jonathan B Demb
Inhibitory interneurons sculpt the outputs of excitatory circuits to expand the dynamic range of information processing. In mammalian retina, more than 30 types of amacrine cells provide lateral inhibition to vertical, excitatory bipolar cell circuits, but functional roles for only a few amacrine cells are well established. Here, we elucidate the function of corticotropin-releasing hormone (CRH)-expressing amacrine cells labeled in Cre transgenic mice of either sex. CRH cells co-stratify with the ON Alpha ganglion cell, a neuron highly sensitive to positive contrast...
March 23, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29545118/cognitive-benefits-of-lithium-chloride-in-app-ps1-mice-are-associated-with-enhanced-brain-clearance-of-%C3%AE-amyloid
#20
Yijun Pan, Jennifer L Short, Stephanie A Newman, Kwok H C Choy, Durgesh Tiwari, Christopher Yap, Danielle Senyschyn, William A Banks, Joseph A Nicolazzo
Epidemiological evidence suggests that people with bipolar disorder prescribed lithium exhibit a lower risk of Alzheimer's disease (AD) relative to those prescribed other mood-stabilizing medicines. Lithium chloride (LiCl) reduces brain β-amyloid (Aβ) levels, and the brain clearance of Aβ is reduced in AD. Therefore, the purpose of this study was to assess whether the cognitive benefits of LiCl are associated with enhanced brain clearance of exogenously-administered Aβ. The brain clearance of intracerebroventricularly (icv) administered125 I-Aβ42 was assessed in male Swiss outbred mice administered daily oral NaCl or LiCl (300 mg/kg for 21 days)...
March 12, 2018: Brain, Behavior, and Immunity
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