Annika Valtari, Susanna Posio, Elisa Toropainen, Anusha Balla, Jooseppi Puranen, Amir Sadeghi, Marika Ruponen, Veli-Pekka Ranta, Kati-Sisko Vellonen, Arto Urtti, Eva M Del Amo
Even though subconjunctival injections are used in clinics, their quantitative pharmacokinetics has not been studied systematically. For this purpose, we evaluated the ocular and plasma pharmacokinetics of subconjunctival dexamethasone in rabbits. Intravenous injection was also given to enable a better understanding of the systemic pharmacokinetics. Dexamethasone concentrations in plasma (after subconjunctival and intravenous injections) and four ocular tissues (iris-ciliary body, aqueous humour, neural retina and vitreous) were analysed using LC-MS/MS...
March 12, 2024: European Journal of Pharmaceutics and Biopharmaceutics