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https://www.readbyqxmd.com/read/29678721/acute-tissue-reactions-inner-segment-pathology-and-effects-of-the-antioxidant-%C3%AE-1-microglobulin-in-an-in-vitro-model-of-retinal-detachment
#1
Fredrik Ghosh, Bo Åkerström, Jesper Bergwik, Hodan Abdshill, Lina Gefors, Linnéa Taylor
The purpose of this study was to explore acute tissue reactions, ultrastructural photoreceptor morphology with emphasis on inner segments, and the effect of antioxidant treatment in an in vitro model of rhegmatogenous retinal detachment (RRD). A previously described method of RRD simulation was used with adult retinal porcine explants kept free-floating in culture medium with or without treatment with the radical scavenger α1 -microglobulin (A1M). Explants were examined at 5 time points from 1 to 24 h using transmission electron microscopy as well as quantitative real-time PCR (RT-PCR) to quantify gene expression of the cell stress marker heat shock protein 70 (Hsp70) and oxidative stress marker heme oxygenase (HO-1)...
April 17, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29678592/retina-compatible-interactions-and-effective-modulation-of-blood-ocular-barrier-p-gp-activity-by-third-generation-inhibitors-improves-ocular-penetration-of-loperamide
#2
Karthik Yadav Janga, Akshaya Tatke, Surabhi Shukla, Surya P Lamichhane, Bharathi Avula, XiangDi Wang, Monica M Jablonski, Ikhlas A Khan, Soumyajit Majumdar
Effective drug delivery to the deeper ocular tissues remains an unresolved conundrum mainly due to the expression of multidrug resistance (MDR) efflux proteins, beside tight junction proteins, in the blood ocular barriers (BOB). Hence, the purpose of the current research was to investigate the ability of the third-generation efflux protein inhibitors, elacridar (EQ) and tariquidar (TQ), to diminish P-glycoprotein (P-gp) mediated efflux transport of loperamide (LOP), a P-gp substrate, across the BOB in SD rats...
April 17, 2018: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29677452/vitreous-levels-of-luteinizing-hormone-and-vegf-are-strongly-correlated-in-healthy-mammalian-eyes
#3
Tammy Z Movsas, Robert Sigler, Arivalagan Muthusamy
Purpose/Aim: Luteinizing hormone (LH) is known to function as a key regulator of VEGF expression in reproductive organs. In recent years, LH has also been detected in human vitreous and LH receptors have been identified in human retina. This study was aimed to investigate a potential correlation between LH and VEGF levels in healthy mammalian eyes to provide supporting evidence of LH's potential involvement in intraocular VEGF regulation. METHODS: 18 bovine and 30 porcine eyes were procured from an abattoire and VEGF and LH levels were measured in the vitreous extracted from these eyes by commercially-available bovine & porcine ELISA assay kits...
April 20, 2018: Current Eye Research
https://www.readbyqxmd.com/read/29675374/comparison-of-three-fluorescence-labeling-and-tracking-methods-of-endothelial-progenitor-cells-in-laser-injured-retina
#4
Hui Shi, Xin-Rui Wang, Ming-Chao Bi, Wei Yang, Dan Wang, Hai-Le Liu, Ling-Ling Liang, Xiao-Hong Li, Qian Hao, Zhi-Hua Cui, E Song
AIM: To compare three kinds of fluorescent probes for in vitro labeling and in vivo tracking of endothelial progenitor cells (EPCs) in a mouse model of laser-induced retinal injury. METHODS: EPCs were isolated from human umbilical cord blood mononuclear cells and labeled with three different fluorescent probes: 5-(and-6)-carboxyfluorescein diacetate succinimidyl ester (CFSE), 1,1'-dilinoleyl-3,3,3',3'-tetramethylindo-carbocyanine perchlorate linked acetylated low-density lipoprotein (DiI-AcLDL), and green fluorescent protein (GFP)...
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29669371/need-for-quantitative-measurement-methods-for-posterior-uveitis-comparison-of-dual-fa-icga-angiography-edi-oct-choroidal-thickness-and-sun-vitreous-haze-evaluation-in-stromal-choroiditis
#5
Filippo Fabro, Carl P Herbort
BACKGROUND/PURPOSE: Quantitative methods for posterior uveitis are necessary for precise appraisal and follow-up of inflammation in practice and in clinical trials. The aim of this study was to assess fluorescein angiography (FA), indocanine green angiography (ICGA), and enhanced depth imaging optical coherence tomography choroidal thickness (EDI-OCT CT) in two stromal choroiditis entities, birdshot retinochoroiditis (BRC), and Vogt-Koyanagi-Harada disease (VKH), as well as to determine (1) disease patterns, (2) respective response to therapy, and (3) their potential utility in clinical trials in comparison to vitreous haze, the present standard outcome used in clinical trials...
April 2018: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29655781/the-hyperopic-effect-of-narrow-band-long-wavelength-light-in-tree-shrews-increases-non-linearly-with-duration
#6
Alexander H Ward, Thomas T Norton, Carrie E Huisingh, Timothy J Gawne
During postnatal refractive development, an emmetropization mechanism uses refractive error to modulate the growth rate of the eye. Hyperopia (image focused behind the retina) produces what has been described as "GO" signaling that increases growth. Myopia (image focused in front of the retina) produces "STOP" signaling that slows growth. The interaction between GO and STOP conditions is non-linear; brief daily exposure to STOP counteracts long periods of GO. In young tree shrews, long-wavelength (red) light, presented 14 h per day, also appears to produce STOP signals...
April 12, 2018: Vision Research
https://www.readbyqxmd.com/read/29643808/innovative-nanoparticles-enhance-n-palmitoylethanolamide-intraocular-delivery
#7
Carmelo Puglia, Paolo Blasi, Carmine Ostacolo, Eduardo Sommella, Claudio Bucolo, Chiara B M Platania, Giovanni L Romano, Federica Geraci, Filippo Drago, Debora Santonocito, Barbara Albertini, Pietro Campiglia, Giovanni Puglisi, Rosario Pignatello
Nanostructured lipid carriers (NLCs) loaded with palmitoylethanolamide (PEA) were formulated with the aim to enhance ocular bioavailability of PEA, particularly to the back of the eye. Technological characterization (e.g., size, charge) of NLC loaded with PEA formulation (PEA-NLC) was performed, and NLC morphology was characterized by electron microscopy. Ocular pharmacokinetic study, after topical administration of the formulation, was carried out in rabbit eye. Ultra-high performance liquid chromatography tandem mass spectrometry analysis was carried out to detect PEA levels in ocular tissues...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29643781/two-cases-of-rhegmatogenous-retinal-detachment-associated-with-asteroid-hyalosis
#8
Yoshitaka Okuda, Keigo Kakurai, Takaki Sato, Seita Morishita, Masanori Fukumoto, Ryohsuke Kohmoto, Mai Takagi, Takatoshi Kobayashi, Teruyo Kida, Tsunehiko Ikeda
Background: To report two cases of rhegmatogenous retinal detachment (RRD) associated with asteroid hyalosis (AH). Case Presentation: Two patients presented with RRD originating from a flap tear. Case 1 involved a 62-year-old male who was found to have bullous RRD in his left eye originating from a flap tear. During vitreous surgery, a thick vitreous cortex was found to have strongly adhered to the entire retinal surface, from the center to the periphery. A bimanual method was then used in conjunction with the vitrectomy to create an artificial posterior vitreous detachment...
January 2018: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/29643775/case-report-of-a-family-affected-by-stickler-syndrome-in-which-rhegmatogenous-retinal-detachment-occurred-in-five-eyes-of-three-siblings
#9
Daisaku Kimura, Takaki Sato, Shou Oosuka, Ryohsuke Kohmoto, Masanori Fukumoto, Masashi Mimura, Kensuke Tajiri, Takatoshi Kobayashi, Teruyo Kida, Tsunehiko Ikeda
Purpose: Stickler syndrome is an autosomal dominant inherited disorder that is well known to be highly associated with the development of rhegmatogenous retinal detachment. In this study, we report the case of a family affected by Stickler syndrome in which rhegmatogenous retinal detachment developed in 5 eyes of 3 siblings. Case Series: For treatment, we performed vitreous surgery on 1 eye of the eldest son, and bilateral scleral buckling surgery on the 2 younger children...
January 2018: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/29643027/-purtscher-like-retinopathy-associated-with-antibiotic-anaphylaxis
#10
Zhi-Xuan Huang, Zhi-Bing Zeng, Zhu-Ping Xu
We report a case of an 18-year-old woman with systemic antibiotic anaphylaxis who presented anasarca and bilateral visual loss two weeks after the intravenous use of pazufloxacin. Ancillary fundus tests revealed bilateral cotton-wool spots, Purtscher flecken, edema, and retinal arteriolar occlusion around the optic disc. After pulse corticosteroid, administration of anti-anaphylactic agent, and general support therapy for one month, the patient showed a favorable change, with the symptoms lessened or free systemically, except the continuous aggravation of fundus ischemic change...
March 20, 2018: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/29625461/allogeneic-ipsc-derived-rpe-cell-graft-failure-following-transplantation-into-the-subretinal-space-in-nonhuman-primates
#11
Trevor J McGill, Jonathan Stoddard, Lauren M Renner, Ilhem Messaoudi, Kapil Bharti, Shoukhrat Mitalipov, Andreas Lauer, David J Wilson, Martha Neuringer
Purpose: To characterize the intraocular immune response following transplantation of iPS-derived allogeneic RPE cells into the subretinal space of non-immune-suppressed rhesus macaques. Methods: GFP-labeled allogeneic iPS-derived RPE cells were transplanted into the subretinal space of one eye (n = 6), and into the contralateral eye 1 day to 4 weeks later, using a two-stage transretinal and transscleral approach. Retinas were examined pre- and post-surgery by color fundus photography, fundus autofluorescence, and optical coherence tomography (OCT) imaging...
March 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29623721/evaluation-of-ocular-perforation-during-retrobulbar-block-using-high-resolution-spectral-domain-optical-coherence-tomography-and-optical-coherence-tomography-angiography
#12
Stanislao Rizzo, Ruggero Tartaro, Lucia Finocchio, Andrea Giorni, Daniela Bacherini, Alfonso Savastano
INTRODUCTION: This article reports a case of ocular perforation during a retrobulbar block in a patient who underwent scleral buckle for retinal detachment. METHODS: Sterile air was immediately injected into the vitreous cavity to restore intraocular pressure and the scleral buckle operation was quickly finished. One week later, a laser retinopexy was performed on the two retinal holes that were outside the foveal area. After 6 months, spectral domain-optical coherence tomography and optical coherence tomography angiography were performed on the perforated wall centered on the exit hole area...
March 1, 2018: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/29608907/m-to-l-cone-ratios-determine-eye-sizes-and-baseline-refractions-in-chickens
#13
Sandra Gisbert, Frank Schaeffel
Following a hypothesis raised by M. and J. Neitz, Seattle, we have tested whether the abundance and the ratio of Long wavelength-sensitive (L) to Middle wavelength-sensitive (M) cones may affect eye size and development of myopia in the chicken. Fourteen chickens were treated with frosted plastic diffusers in front of one eye on day 10 post-hatching for a period of 7 days to induce deprivation myopia. Ocular dimensions were measured by A-scan ultrasonography at the beginning and at the end of the treatment and development of refractive state was tracked using infrared photorefraction...
March 30, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29600187/endoscopy-assisted-vitrectomy-in-the-anterior-vitreous
#14
REVIEW
Yong-Zhen Yu, Yu-Ping Zou, Xiu-Lan Zou
Endoscopy-assisted ocular surgery is a relatively old technique that is increasingly being recognized for its application in cases of vitreoretinal disease. This technique is especially useful when both the vitreous and retina are difficult to access because of media opacity, a small pupil, or a microcornea. In this context, the anterior vitreous is often difficult to dissect because of its complex pathological changes. This article reviews the common anatomical features and pathologies that are observed in the anterior vitreous, as well as the applications and indications of endoscopy-assisted vitrectomy in the anterior vitreous...
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29597134/hyaluronic-acid-coated-albumin-nanoparticles-for-targeted-peptide-delivery-in-the-treatment-of-retinal-ischaemia
#15
Di Huang, Ying-Shan Chen, Colin R Green, Ilva D Rupenthal
Recent studies have shown that Connexin43 mimetic peptide (Cx43 MP) can prevent secondary damage following retinal ischaemic and inflammatory disorders by blocking uncontrolled Cx43 hemichannel opening. However, limitations in peptide stability and the presence of various intraocular barriers limit efficient retinal delivery in the clinical setting. The present study aimed to achieve targeted and sustained peptide delivery to the retina by encapsulating Cx43 MP into hyaluronic acid (HA) coated albumin nanoparticles (NPs)...
March 20, 2018: Biomaterials
https://www.readbyqxmd.com/read/29596552/yield-techniques-and-complications-of-transvitreal-and-transscleral-biopsies-in-small-uveal-melanoma
#16
Ryan Sangwoo Kim, Patricia Chevez-Barrios, Mukul Divatia, Maria Eugenia Bretana, Bin Teh, Amy Claire Schefler
Importance: Intraoperative adequacy check of biopsy samples can lead to a higher biopsy yield rate, and subsequent genomic analysis can provide patients with valuable prognostic information. Objectives: To examine the yield rates for transscleral and transvitreal fine-needle aspiration biopsies of small uveal melanoma less than 3.6 mm in apical height and to discuss techniques that would maximize yield rates and minimize complications. Design, Setting, and Participants: A retrospective, consecutive observational case series was conducted from January 29, 2013, to May 23, 2017, at Retina Consultants of Houston and Houston Methodist Hospital among 44 patients with uveal melanoma of the ciliary body or choroid...
March 29, 2018: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29592777/an-intraocular-micro-light-emitting-diode-device-for-endo-illumination-during-pars-plana-vitrectomy
#17
Philipp S Koelbl, Christian Lingenfelder, Christoph W Spraul, Juergen Kampmeier, Frank Hj Koch, Yong Keun Kim, Martin Hessling
PURPOSE: Development of a new, fiber-free, single-use endo-illuminator for pars plana vitrectomy as a replacement for fiber-based systems with external light sources. The hand-guided intraocularly placed white micro light-emitting diode is evaluated for its illumination properties and potential photochemical and thermal hazards. METHODS: A micro light-emitting diode was used to develop a single-use intraocular illumination system. The light-source-on-tip device was implemented in a prototype with 23G trocar compatible outer diameter of 0...
March 1, 2018: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/29584759/anti-inflammatory-cytokine-and-angiogenic-factors-levels-in-vitreous-samples-of-diabetic-retinopathy-patients
#18
Teresa Tsai, Sandra Kuehn, Nikolaos Tsiampalis, Minh-Khoa Vu, Vinodh Kakkassery, Gesa Stute, H Burkhard Dick, Stephanie C Joachim
Evaluation of cytokines in patients with diabetic retinopathy (DR) is important for the identification of future additive or alternative treatment options. Therefore, vitreous samples were obtained from patients with DR and patients with macular hole or macular pucker (control group) during 23-gauge-vitrectomy (n = 17/group). The levels of three pro-inflammatory (IL-1ß, IL-6, IFN-γ) and pleiotropic cytokines (IL-2, IL-4, IL-13) as well as VEGF, VEGF-A, and PGF were measured using an enzyme linked immunosorbent assay (ELISA)...
2018: PloS One
https://www.readbyqxmd.com/read/29584529/characterization-and-pharmacokinetics-of-triamcinolone-acetonide-loaded-liposomes-topical-formulations-for-vitreoretinal-drug-delivery
#19
Juan C Altamirano-Vallejo, Jose Navarro-Partida, Alejandro Gonzalez-De la Rosa, Jane H Hsiao, Jose S Olguín-Gutierrez, Ana C Gonzalez-Villegas, Brian C Keller, Lourdes Bouzo-Lopez, Arturo Santos
PURPOSE: To achieve a safer alternative to intravitreal injection of corticosteroids, we developed and characterized triamcinolone acetonide-loaded liposomes formulations (TA-LFs) to be used topically for vitreoretinal drug delivery. METHODS: Four different 0.2% TA-LFs (TA-LF1 to TA-LF4) were generated and submitted to physicochemical characterization. Posteriorly, an ex vivo diffusion assay was performed using rabbit corneas as membranes. Finally, concentrations of triamcinolone acetonide (TA) were determined by high-performance liquid chromatography in ocular tissues from New Zealand white rabbits after multiple topical doses of TA-LF2 (6 times per day, 14 days)...
March 27, 2018: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29580956/the-use-of-miltefosine-in-the-management-of-refractory-acanthamoeba-keratitis
#20
Shokufeh Tavassoli, Miranda Buckle, Derek Tole, Peter Chiodini, Kieren Darcy
Acanthamoeba keratitis (AK) is a sight threatening infection most commonly affecting contact lens wearers. The authors report a case of intractable A.polyphaga and A.castellanii, with extensive intraocular spread, managed using oral miltefosine. A 59-year old male contact lens wearer was referred to the tertiary corneal service at Bristol Eye Hospital. Vision was hand movements on the left and 6/6 on the right. Clinical examination was consistent with left AK (confirmed by corneal scrape). Management included biguanide (polyhexamethylene biguanide (PHMB) 0...
March 23, 2018: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
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