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https://www.readbyqxmd.com/read/28072615/retinal-detachment-associated-with-peripapillary-staphyloma-imaged-with-swept-source-optical-coherence-tomography
#1
Daisuke Kunita, Makoto Inoue, Takashi Koto, Akito Hirakata
PURPOSE: To examine a rhegmatogenous retinal detachment (RRD) associated with a peripapillary staphyloma with swept source optical coherence tomography (SS-OCT) before and after vitrectomy and circumferential photocoagulation. METHODS: The SS-OCT images including the montage images of two patients with a RRD associated with peripapillary staphylomas were analyzed. A 34-year-old woman (Case 1) and a 70-year-old woman (Case 2) both noticed temporal visual field defects in their left eyes...
January 9, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28060400/retinal-detachment-in-a-combined-case-of-stickler-syndrome-and-x-linked-retinoschisis
#2
Neesurg S Mehta, Nicolas A Yannuzzi, Ryan Young, Andrew J McClellan, Sarah P Read, Audina M Berrocal
A 12-year-old boy presented with a total rhegmatogenous retinal detachment and a giant retinal tear in the right eye. Clinical examination, optical coherence tomography, and fundus images showed an optically empty vitreous, lattice degeneration, and retinoschisis of the macula. Genetic testing revealed mutations in the COL2A1 and RS1 genes, confirming a dual diagnosis of Stickler syndrome and X-linked retinoschisis, respectively. This represents the first published account of a patient with both Stickler syndrome and X-linked retinoschisis...
January 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28060394/results-of-peripheral-vitrectomy-under-air-in-rhegmatogenous-retinal-detachment
#3
Tugrul Altan, Kemal Turgay Ozbilen, Turgay Cetin, Ziya Kapran
BACKGROUND AND OBJECTIVE: To evaluate the safety and efficacy of peripheral vitrectomy under air in rhegmatogenous retinal detachment (RRD). PATIENTS AND METHODS: Consecutive patients who underwent 23-gauge pars plana vitrectomy for RRD were included. After removal of core vitreous and drainage of subretinal fluid, peripheral vitreous was removed under air infusion without scleral indentation. Silicone oil or C3F8 gas was used as tamponade. RESULTS: Forty-five eyes of 45 patients were evaluated retrospectively...
January 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28060316/an-alternative-and-validated-injection-method-for-accessing-the-subretinal-space-via-a-transcleral-posterior-approach
#4
Sachin Parikh, Andrew Le, Julian Davenport, Michael B Gorin, Steven Nusinowitz, Anna Matynia
Subretinal injections have been successfully used in both humans and rodents to deliver therapeutic interventions of proteins, viral agents, and cells to the interphotoreceptor/subretinal compartment that has direct exposure to photoreceptors and the retinal pigment epithelium (RPE). Subretinal injections of plasminogen as well as recent preclinical and clinical trials have demonstrated safety and/or efficacy of delivering viral vectors and stem cells to individuals with advanced retinal disease. Mouse models of retinal disease, particularly hereditary retinal dystrophies, are essential for testing these therapies...
December 7, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28058163/clinical-features-and-course-of-patients-with-peripheral-exudative-hemorrhagic-chorioretinopathy
#5
Zafer Cebeci, Yasemin Dere, Şerife Bayraktar, Samuray Tuncer, Nur Kır
OBJECTIVES: To evaluate the clinical characteristics of patients who were followed in our clinic with the diagnosis of peripheral exudative hemorrhagic chorioretinopathy (PEHC). MATERIALS AND METHODS: Medical records of 12 patients who were diagnosed with PEHC in İstanbul University İstanbul Faculty of Medicine, Department of Ophthalmology between July 2006 and June 2014 were reviewed retrospectively. RESULTS: This study included 21 eyes of 12 patients...
October 2016: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28050328/cataract-surgery-after-retinal-detachment-surgery-with-arruga-s-sutures-case-report
#6
Erkan Ünsal, Kadir Eltutar, Osman Kızılay, Belma Karini
A 56-year old female patient presented to our clinic with a complaint of low vision in her right eye. Twenty-two years earlier she had undergone a scleral buckling operation in her right eye because of retinal detachment. She indicated that vision in her right eye was good after the surgery but had recently been gradually declining. Best-corrected vision acuity was counting fingers at 1 meter in the right eye and 8/10 in the left eye. Anterior segment examination revealed stage 3 nuclear cataract in the right eye...
December 2016: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28045789/imaging-and-measurement-of-the-preretinal-space-in-vitreomacular-adhesion-and-vitreomacular-traction-by-a-new-spectral-domain-optical-coherence-tomography-analysis
#7
Marcin Stopa, Elżbieta Marciniak, Piotr Rakowicz, Agnieszka Stankiewicz, Tomasz Marciniak, Adam Dąbrowski
PURPOSE: To evaluate a new method for volumetric imaging of the preretinal space (also known as the subhyaloid, subcortical, or retrocortical space) and investigate differences in preretinal space volume in vitreomacular adhesion (VMA) and vitreomacular traction (VMT). METHODS: Nine patients with VMA and 13 with VMT were prospectively evaluated. Automatic inner limiting membrane line segmentation, which exploits graph search theory implementation, and posterior cortical vitreous line segmentation were performed on 141 horizontal spectral domain optical coherence tomography B-scans per patient...
December 30, 2016: Retina
https://www.readbyqxmd.com/read/28041966/different-roles-of-retinal-dopamine-in-albino-guinea-pig-myopia
#8
Junfeng Mao, Shuangzhen Liu
PURPOSE: To investigate whether the different role of ocular dopamine was involved in the myopic development between spontaneous myopia (SM) and form deprivation myopia (FDM) in albino guinea pigs. METHODS: 55 myopic animals were randomly divided into SM, Levodapa (L-DOPA), L-DOPA+carbidopa and vehicle. 70 non-myopic animals were randomly divided into normal control, FDM, L-DOPA+FDM, L-DOPA+carbidopa+FDM and vehicle. Once per day, for 14days, L-DOPA (10mg/kg) was injected intraperitoneally, and carbidopa (1μg) was injected at the same time into the peribulbar space of the right eye...
December 29, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/28040528/role-of-diagnostic-endoscopy-in-posterior-segment-evaluation-for-definitive-prognostication-in-eyes-with-corneal-opacification
#9
Rajeev R Reddy Pappuru, Mudit Tyagi, Remya M Paulose, Vivek P Dave, Taraprasad Das, Jay Chhablani, Raja Narayanan, Rushil K Saxena, Divya Balakrishnan, Sayan Basu, Virender S Sangwan
PURPOSE: Direct visualization of the posterior segment is not possible with conventional imaging techniques in eyes with corneal opacification. This study evaluated the efficacy of video-endoscopy in visualising and hence prognosticating the visual outcomes in such eyes . DESIGN: Prospective non-comparative consecutive interventional case series. METHODS: This study included 64 eyes of 64 patients with corneal opacification who underwent diagnostic ophthalmic endoscopy procedure from March 2014 to May 2016...
December 28, 2016: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28039002/different-gene-knockout-transgenic-mouse-models-manifesting-persistent-fetal-vasculature-are-integrins-to-blame-for-this-pathological-condition
#10
REVIEW
Shylaja Hegde, Om Srivastava
Persistent fetal vasculature (PFV) occurs as a result of a failure of fetal vasculature to undergo normal programmed involution. During development, before the formation of retinal vessels, the lens and the inner retina are nourished by the hyaloid vasculature. Hyaloid vessels extend from the optic nerve and run through the vitreous to encapsulate the lens. As fetal retinal vessels develop, hyaloid vasculature naturally regresses. Failure of regression of the hyaloid artery has been shown to lead to severe congenital pathologies...
December 27, 2016: Life Sciences
https://www.readbyqxmd.com/read/28002266/retina-the-journal-of-retinal-and-vitreous-diseases-2016-scientific-reviewers
#11
(no author information available yet)
No abstract text is available yet for this article.
January 2017: Retina
https://www.readbyqxmd.com/read/28000874/changes-in-tl1a-levels-and-associated-cytokines-during-pathogenesis-of-diabetic-retinopathy
#12
Zhu-Hong Zhang, Qing-Zhong Chen, Feng Jiang, Todd A Townsend, Chun-Jie Mao, Cai-Yun You, Wen-Hui Yang, Zhi-Yong Sun, Jin-Guo Yu, Hua Yan
Tumor necrosis factor (TNF) ligand related molecule 1A (TL1A), also termed TNF superfamily member 15 and vascular endothelial growth inhibitor is important for tumorigenicity and autoimmunity. However, the function of TL1A in diabetic retinopathy (DR) remains to be elucidated. The present study established a diabetes mellitus (DM) rat model to investigate TL1A, vascular endothelial growth factor (VEGF), tumor necrosis factor‑α (TNF‑α) and interleukin‑1β (IL‑1β) expression levels in the retina, vitreous and serum of rats with DM at different stages (1 month group, 3 month group and 6 month group)...
December 14, 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27994436/role-of-endogenous-insulin-gene-enhancer-protein-isl-1-in-angiogenesis
#13
Si-Qi Xiong, Hai-Bo Jiang, Yan-Xiu Li, Hai-Bo Li, Hui-Zhuo Xu, Zhen-Kai Wu, Wei Zheng, Xiao-Bo Xia
OBJECTIVE: To elucidate the role of insulin gene enhancer protein ISL-1 (Islet-1) in angiogenesis and regulation of vascular endothelial growth factor (VEGF) expression in vitro and in vivo. METHODS: siRNA targeting Islet-1 was transfected to human umbilical vein endothelial cell lines (HUVECs). The expression of Islet-1 and VEGF in the cultured cells was measured using real-time PCR and immunoblotting. 3-[4,5-dimethylthiazol-2-yl]-2,5- diphenyltetrazolium bromide; thiazolyl blue (MTT) assay was used to analyze the proliferation of HUVECs affected by Islet-1...
2016: Molecular Vision
https://www.readbyqxmd.com/read/27993590/prevalence-of-anti-retinal-antibodies-in-acute-zonal-occult-outer-retinopathy-azoor-a-comprehensive-review-of-25-cases
#14
Cynthia X Qian, Angeline Wang, David L DeMill, Thiran Jayasundera, Kari Branham, Maria Fernanda Abalem, Naheed Khan, John R Heckenlively
PURPOSE: To perform a comprehensive review and to investigate the presence and role of autoimmune antibodies in 25 cases of acute zonal occult outer retinopathy (AZOOR) identified using the classification originally proposed by J.Donald Gass. DESIGN: Observational case series METHODS: Setting: Institutional Study Population: Twenty-five patients were identified by characteristic symptoms (abrupt onset of photopsias, followed by large scotomata at or connected to the blind spot), ocular findings (paucity of pigmentary changes with no sign of vitreous inflammation and abnormal electroretinogram in at least one eye,) and a negative family history for retinitis pigmentosa...
December 16, 2016: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/27990359/effect-of-endothelial-progenitor-cells-derived-from-human-umbilical-cord-blood-on-oxygen-induced-retinopathy-in-mice-by-intravitreal-transplantation
#15
Dan Wang, Bo Zhang, Hui Shi, Wei Yang, Ming-Chao Bi, Xiang-Fu Song, Chen Zhang, Jian-Hui Cheng, Ji-Long Hao, E Song
AIM: To investigate the effect of endothelial progenitor cells (EPCs) labeled by carboxy fluorescein diacetate succinimidyl ester (CFSE) on murine oxygen-induced retinopathy (OIR) by intravitreal transplantation. METHODS: After isolated from human umbilical cord blood mononuclear cells, EPCs were cultivated and then labeled with CFSE in vitro. C57BL/6J mice were placed to 75% hyperoxia chamber from P7 to P12 to establish OIR model. At P12, OIR mice were intravitreally injected with 1 µL suspension contained 2×10(5) EPCs (EPCs group) or isometric phosphate buffered saline (PBS group)...
2016: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/27986386/intraocular-hemorrhages-and-retinopathy-of-prematurity-in-the-telemedicine-approaches-to-evaluating-acute-phase-retinopathy-of-prematurity-e-rop-study
#16
Ebenezer Daniel, Gui-Shuang Ying, R Michael Siatkowski, Wei Pan, Eli Smith, Graham E Quinn
PURPOSE: To describe the clinical characteristics of intraocular hemorrhages (IOHs) in infants in the Telemedicine Approaches to Evaluating Acute-Phase Retinopathy of Prematurity (e-ROP) Study and to evaluate their potential use for prediction of disease severity. DESIGN: Secondary data analysis from a prospective study. PARTICIPANTS: Preterm infants with birth weight (BW) ≤1250 g. METHODS: Infants underwent serial digital retinal imaging in both eyes starting at 32 weeks' postmenstrual age...
December 13, 2016: Ophthalmology
https://www.readbyqxmd.com/read/27979713/the-wavelength-composition-and-temporal-modulation-of-ambient-lighting-strongly-affect-refractive-development-in-young-tree-shrews
#17
Timothy J Gawne, John T Siegwart, Alexander H Ward, Thomas T Norton
Shortly after birth, the eyes of most animals (including humans) are hyperopic because the short axial length places the retina in front of the focal plane. During postnatal development, an emmetropization mechanism uses cues related to refractive error to modulate the growth of the eye, moving the retina toward the focal plane. One possible cue may be longitudinal chromatic aberration (LCA), to signal if eyes are getting too long (long [red] wavelengths in better focus than short [blue]) or too short (short wavelengths in better focus)...
December 12, 2016: Experimental Eye Research
https://www.readbyqxmd.com/read/27977843/occult-perforating-globe-injury-caused-by-intraocular-foreign-body
#18
Yoshihiro Yonekawa, Cynthia X Qian, Avni V Patel, Leo A Kim, Dean Eliott
Intraocular foreign bodies (IOFBs) may be associated with occult exit wounds. The authors present a case of a man who sustained a zipper-tooth IOFB through the cornea from a car tire explosion. CT showed an IOFB within the vitreous cavity, but the IOFB was not identified during vitrectomy. Extension of the peritomy revealed an exit wound with the foreign body lodged in the extraocular space. This case demonstrates that IOFBs can rest within the vitreous cavity after creating an exit wound, but may escape detection by being driven back out of the globe during vitrectomy due to the pressurized eye...
December 1, 2016: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/27959948/effects-of-constant-flickering-light-on-refractive-status-5-ht-and-5-ht2a-receptor-in-guinea-pigs
#19
Bing Li, Xiumei Luo, Tao Li, Changyue Zheng, Shunmei Ji, Yuanyuan Ma, Shuangshuang Zhang, Xiaodong Zhou
PURPOSE: To investigate the effects of constant flickering light on refractive development, the role of serotonin (i.e.5-hydroxytryptamine, 5-HT)and 5-HT2A receptor in myopia induced by flickering light in guinea pigs. METHODS: Forty-five guinea pigs were randomly divided into three groups: control, form deprivation myopia (FDM) and flickering light induced myopia (FLM) groups(n = 15 for each group). The right eyes of the FDM group were covered with semitransparent hemispherical plastic shells serving as eye diffusers...
2016: PloS One
https://www.readbyqxmd.com/read/27959848/-tubulointerstitial-nephritis-syndrome-and-uveitis
#20
Carolina A Isnardi, Andrés Vilela, Pablo Kuschner, Carolina Salvo, Cecilia Vanzetti, Hugo Zelechower, Adriana Arpa
Intermediate uveitis is described as inflammation in the anterior vitreous, ciliary body and the peripheral retina. It is a subset of uveitis where the vitreous is the major site of damage. It has been reported to be associated with many local and systemic inflammatory and infectious diseases. An infrequent cause is the tubulointerstitial nephritis and uveitis syndrome. We report a case of an acute visual acuity loss related with renal failure in a 64 years old woman with Hashimoto disease. It was an acute tubulointerstitial nephritis and uveitis syndrome case...
2016: Medicina
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