keyword
https://read.qxmd.com/read/38429638/closing-the-gaps-in-patient-management-of-dyslipidemia-stepping-into-cardiovascular-precision-diagnostics-with-apolipoprotein-profiling
#21
REVIEW
Esther Reijnders, Arnoud van der Laarse, L Renee Ruhaak, Christa M Cobbaert
In persons with dyslipidemia, a high residual risk of cardiovascular disease remains despite lipid lowering therapy. Current cardiovascular risk prediction mainly focuses on low-density lipoprotein cholesterol (LDL-c) levels, neglecting other contributing risk factors. Moreover, the efficacy of LDL-c lowering by statins resulting in reduced cardiovascular risk is only partially effective. Secondly, from a metrological viewpoint LDL-c falls short as a reliable measurand. Both direct and calculated LDL-c tests produce inaccurate test results at the low end under aggressive lipid lowering therapy...
March 1, 2024: Clinical Proteomics
https://read.qxmd.com/read/38425491/clinical-outcomes-and-tau-pathology-in-retired-football-players-associations-with-diagnosed-and-witnessed-sleep-apnea
#22
JOURNAL ARTICLE
Sarah J Banks, Eukyung Yhang, Yorghos Tripodis, Yi Su, Hillary Protas, Charles H Adler, Laura J Balcer, Charles Bernick, Jesse B Mez, Joseph Palmisano, William B Barr, Jennifer V Wethe, David W Dodick, Michael D Mcclean, Brett Martin, Kaitlin Hartlage, Arlener Turner, Robert W Turner, Atul Malhotra, Michael Colman, Ofer Pasternak, Alexander P Lin, Inga K Koerte, Sylvain Bouix, Jeffrey L Cummings, Martha E Shenton, Eric M Reiman, Robert A Stern, Michael L Alosco
BACKGROUND AND OBJECTIVES: Obstructive sleep apnea (SA) is common in older men and a contributor to negative cognitive, psychiatric, and brain health outcomes. Little is known about SA in those who played contact sports and are at increased risk of neurodegenerative disease(s) and other neuropathologies associated with repetitive head impacts (RHI). In this study, we investigated the frequency of diagnosed and witnessed SA and its contribution to clinical symptoms and tau pathology using PET imaging among male former college and former professional American football players...
April 2024: Neurology. Clinical Practice
https://read.qxmd.com/read/38423192/the-free-plasma-amyloid-a%C3%AE-1-42-a%C3%AE-1-40-ratio-predicts-conversion-to-dementia-for-subjects-with-mild-cognitive-impairment-with-performance-equivalent-to-that-of-the-total-plasma-a%C3%AE-1-42-a%C3%AE-1-40-ratio-the-baltazar-study
#23
JOURNAL ARTICLE
S Schraen-Maschke, A Duhamel, J S Vidal, N Ramdane, L Vaudran, C Dussart, L Buée, B Sablonnière, C Delaby, B Allinquant, A Gabelle, S Bombois, S Lehmann, O Hanon
BACKGROUND AND PURPOSE: Blood-based biomarkers are a non-invasive solution to predict the risk of conversion of mild cognitive impairment (MCI) to dementia. The utility of free plasma amyloid peptides (not bound to plasma proteins and/or cells) as an early indicator of conversion to dementia is still debated, as the results of studies have been contradictory. In this context, we investigated whether plasma levels of the free amyloid peptides Aβ1-42 and Aβ1-40 and the free plasma Aβ1-42 /Aβ1-40 ratio are associated with the conversion of MCI to dementia, in particular AD, over three years of follow-up in a subgroup of the BALTAZAR cohort...
February 27, 2024: Neurobiology of Disease
https://read.qxmd.com/read/38422898/high-glucose-levels-accelerate-atherosclerosis-via-nlrp3-il-mapk-nf-%C3%AE%C2%BAb-related-inflammation-pathways
#24
JOURNAL ARTICLE
Hui Sun, Xiaotian Ma, Hong Ma, Shuen Li, Yan Xia, Lijie Yao, Yingcui Wang, Xuelian Pang, Jingquan Zhong, Guihua Yao, Xiaoling Liu, Mei Zhang
BACKGROUND: As a chronic inflammatory disease, diabetes mellitus (DM) contributes to the development of atherosclerosis (AS). However, how the NLRP3 inflammasome participates in diabetes-related AS remains unclear. Therefore, this study aimed to elucidate the mechanism through which NLRP3 uses high glucose (HG) levels to promote AS. METHODS: Serum and coronary artery tissues were collected from coronary artery disease (CAD) patients with and without DM, respectively...
February 22, 2024: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/38417185/ganoderic-acids-alleviate-atherosclerosis-by-inhibiting-macrophage-m1-polarization-via-tlr4-myd88-nf-%C3%AE%C2%BAb-signaling-pathway
#25
JOURNAL ARTICLE
Ya-Zhu Quan, Ang Ma, Chao-Qun Ren, Yong-Pan An, Pan-Shuang Qiao, Cai Gao, Yu-Kun Zhang, Xiao-Wei Li, Si-Mei Lin, Nan-Nan Li, Di-Long Chen, Yan Pan, Hong Zhou, Dong-Mei Lin, Shu-Qian Lin, Min Li, Bao-Xue Yang
BACKGROUND AND AIMS: Atherosclerosis (AS) is a chronic inflammatory disease characterized by lipid infiltration and plaque formation in blood vessel walls. Ganoderic acids (GA), a class of major bioactive compounds isolated from the Chinese traditional medicine Ganoderma lucidum, have multiple pharmacological activities. This study aimed to determine the anti-atherosclerotic effect of GA and reveal the pharmacological mechanism. METHODS: ApoE-/- mice were fed a high-cholesterol diet and treated with GA for 16 weeks to induce AS and identify the effect of GA...
February 8, 2024: Atherosclerosis
https://read.qxmd.com/read/38416138/the-clinical-and-radiographic-degenerative-spondylolisthesis-classification-and-its-predictive-value
#26
JOURNAL ARTICLE
Henrik Constantin Bäcker, Peter Turner, Michael A Johnson, Esther Apos, John Cunningham
INTRODUCTION: The clinical and radiographic degenerative spondylolisthesis (CARDS) classification is a new classification that has been introduced for degenerative spondylolisthesis (DS). It has four categories. Our study aimed to analyse the functional and radiographic outcome following DS surgery based on the preoperative CARDS classification. METHODS: A retrospective study of the prospectively collected Australian Spine Registry database was performed. Data on demographics, patient reported outcome measures including the Oswestry Disability Index (ODI) and EQ-5D-3 L scores, and changes in radiographic measurements were analysed...
February 28, 2024: Archives of Orthopaedic and Trauma Surgery
https://read.qxmd.com/read/38415908/the-bio-hermes-study-biomarker-database-developed-to-investigate-blood-based-and-digital-biomarkers-in-community-based-diverse-populations-clinically-screened-for-alzheimer-s-disease
#27
JOURNAL ARTICLE
Richard C Mohs, Douglas Beauregard, John Dwyer, Jennifer Gaudioso, Jason Bork, Tamiko MaGee-Rodgers, Mickeal N Key, Diana R Kerwin, Lynn Hughes, Cyndy B Cordell
INTRODUCTION: Alzheimer's disease (AD) trial participants are often screened for eligibility by brain amyloid positron emission tomography/cerebrospinal fluid (PET/CSF), which is inefficient as many are not amyloid positive. Use of blood-based biomarkers may reduce screen failures. METHODS: We recruited 755 non-Hispanic White, 115 Hispanic, 112 non-Hispanic Black, and 19 other minority participants across groups of cognitively normal (n = 417), mild cognitive impairment (n = 312), or mild AD (n = 272) participants...
February 28, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://read.qxmd.com/read/38414008/pre-operative-levels-of-angiopoietin-protein-like-3-angptl3-in-women-diagnosed-with-high-grade-serous-carcinoma-of-the-ovary
#28
JOURNAL ARTICLE
Emilie Wong Chong, France-Hélène Joncas, Pierre Douville, Dimcho Bachvarov, Caroline Diorio, Frédéric Calon, Ann-Charlotte Bergeron, Jonatan Blais, Shuk On Annie Leung, Nabil Georges Seidah, Anne Gangloff
Cancer cells need constant supplies of lipids to survive and grow. Lipid dependence has been observed in various types of cancer, including high-grade serous ovarian carcinomas (HGSOC), which is a lethal form of gynecological malignancy. ANGPTL3, PCSK9, and Apo CIII are pivotal lipid-modulating factors, and therapeutic antibodies have been developed against each one (Evinacumab, Evolocumab and Volanesorsen, respectively). The roles -if any- of ANGPTL3, PCSK9, and Apo CIII in HGSOC are unclear. Moreover, levels of these lipid-modulating factors have never been reported before in HGSOC...
February 27, 2024: Lipids in Health and Disease
https://read.qxmd.com/read/38412910/the-importance-of-apo-b-and-lipoprotein-little-a-lp-a
#29
EDITORIAL
Joseph S Alpert, Neil J Stone
No abstract text is available yet for this article.
February 25, 2024: American Journal of Medicine
https://read.qxmd.com/read/38410635/mussel-oil-is-superior-to-fish-oil-in-preventing-atherosclerosis-of-apoe-mice
#30
JOURNAL ARTICLE
Kelei Li, Xiaolei Song, Huiying Li, Xiaotong Kuang, Shiyi Liu, Run Liu, Duo Li
OBJECTIVES: The present study aimed to explore the preventive effect of mussel oil (MO) on atherosclerosis and the potential mechanism in apolipoprotein E-null (ApoE-/- ) mice. METHODS: ApoE-/- mice were fed with a high-fat and high-cholesterol chow and given corn oil (CO), fish oil (FO), MO, or aspirin (ASP, dissolved in CO) by gavage for 12  weeks. The total n-3 polyunsaturated fatty acids (PUFAs) in MO (51.01%) and FO (46.82%) were comparable (mainly C22:6n-3 and C20:5n-3)...
2024: Frontiers in Nutrition
https://read.qxmd.com/read/38401625/the-%C3%AE-crystallin-chaperones-undergo-a-quasi-ordered-co-aggregation-process-in-response-to-saturating-client-interaction
#31
JOURNAL ARTICLE
Adam P Miller, Susan E O'Neill, Kirsten J Lampi, Steve L Reichow
Small heat shock proteins (sHSPs) are ATP-independent chaperones vital to cellular proteostasis, preventing protein aggregation events linked to various human diseases including cataract. The α-crystallins, αA-crystallin (αAc) and αB-crystallin (αBc), represent archetypal sHSPs that exhibit complex polydispersed oligomeric assemblies and rapid subunit exchange dynamics. Yet, our understanding of how this plasticity contributes to chaperone function remains poorly understood. Using biochemical and biophysical analyses combined with single-particle electron microscopy (EM), we examined structural changes in αAc, αBc and native heteromeric lens α-crystallins (αLc) in their apo-states and at varying degree of chaperone saturation leading to co-aggregation, using lysozyme and insulin as model clients...
February 22, 2024: Journal of Molecular Biology
https://read.qxmd.com/read/38396488/could-tumor-necrosis-factor-serve-as-a-marker-for-cardiovascular-risk-factors-and-left-ventricular-hypertrophy-in-patients-with-early-onset-coronary-artery-disease
#32
JOURNAL ARTICLE
Marta Białecka, Violetta Dziedziejko, Krzysztof Safranow, Andrzej Krzystolik, Zuzanna Marcinowska, Dariusz Chlubek, Monika Rać
Introduction: Tumor necrosis factor (TNF), a pro-inflammatory cytokine, can be produced by cardiomyocytes, leading to metabolic disorders in the myocardium. The objective of this study was to assess the relationship between plasma levels of the TNF cytokine and the presence of known biochemical and clinical risk factors for cardiovascular disease, along with the parameters of cardiac morphology in patients diagnosed with coronary artery disease (CAD) at a young age. Materials and Methods: The study group included 75 men aged up to 50 years and 25 women aged up to 55 years...
February 18, 2024: Diagnostics
https://read.qxmd.com/read/38390562/assessment-of-circulating-apoe4-levels-from-dried-blood-spot-samples-in-a-large-survey-setting
#33
JOURNAL ARTICLE
Nis Borbye-Lorenzen, Yacila I Deza-Lougovski, Solveig Holmgaard, Luzia M Weiss, Marie Bækvad-Hansen, Kristin Skogstrand, Anna Rieckmann, Axel Börsch-Supan, Martina Börsch-Supan
INTRODUCTION: The apolipoprotein E ( APOE ) ε4 allele is associated with high risk for Alzheimer's disease. It is unclear whether individual levels of the circulating apoE4 protein in ε4 carriers confer additional risk. Measuring apoE4 protein levels from dried blood spots (DBS) has the potential to provide information on genetic status as well as circulating levels and to include these measures in large survey settings. METHODS: We developed a multiplex immunoassay to detect apoE4 protein levels in DBS from 15,974 participants, aged 50+ from Wave 6 of the Survey of Health, Ageing and Retirement in Europe (SHARE)...
2024: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://read.qxmd.com/read/38387456/harnessing-diversity-to-study-alzheimer-s-disease-a-new-ipsc-resource-from-the-nih-card-and-adni
#34
JOURNAL ARTICLE
Laurel A Screven, Caroline B Pantazis, Katherine M Andersh, Samantha Hong, Dan Vitale, Erika Lara, Ray Yueh Ku, Peter Heutink, Jason Meyer, Kelley Faber, Kwangsik Nho, Andrew J Saykin, Tatiana M Foroud, Mike A Nalls, Cornelis Blauwendraat, Andrew Singleton, Priyanka S Narayan
The iDA Project (iPSCs to Study Diversity in Alzheimer's and Alzheimer's Disease-related Dementias) is generating 200 induced pluripotent stem cell lines from Alzheimer's Disease Neuroimaging Initiative participants. These lines are sex balanced, include common APOE genotypes, span disease stages, and are ancestrally diverse. Cell lines and characterization data will be shared openly.
February 16, 2024: Neuron
https://read.qxmd.com/read/38385139/characteristics-of-serum-lipid-metabolism-among-women-complicated-with-hypertensive-disorders-in-pregnancy-a-retrospective-cohort-study-in-mainland-china
#35
JOURNAL ARTICLE
Lidong Liu, Xiaolei Zhang, Kaizhou Qin, Chengjie Xu, Fangyi Ruan, Yadan Liu, Huanqiang Zhao, Yinan Wang, Yu Xiong, Qiongjie Zhou, Xiaotian Li
BACKGROUND: Altered maternal serum lipid metabolism is associated with hypertensive disorders in pregnancy (HDP). However, its range in pregnancy and characteristic among different subgroups of HDPs are unclear. METHODS: Pregnant women with HDP who underwent antenatal care and delivered in Obstetrics and Gynecology Hospital of Fudan University during January 2018 to August 2022 were enrolled. The levels of total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDLC), low-density lipoprotein cholesterol (LDLC), apolipoprotein (Apo)-A, B, and E, free fatty acids (FFA), and small and dense low-density lipoprotein cholesterol (sdLDL) were measured during 4-16 weeks and 28-42 weeks of pregnancy...
2024: Obstetrics and Gynecology International
https://read.qxmd.com/read/38382916/pleiotropic-beneficial-cardiometabolic-actions-of-a-high-purity-eicosapentaenoic-acid-product-in-high-cardiovascular-risk-individuals
#36
JOURNAL ARTICLE
Charalampos I Liakos, Leonidas Lanaras, Magdalini Bristianou, Dimitrios P Papadopoulos
The ideal approach to the secondary dyslipidemia goal of lowering triglycerides (TG) is not well established. The available ω-3 fatty acid products differ from each other in composition and content. The purpose of the present study was to investigate the effect of a highly purified eicosapentaenoic acid (EPA) formulation on cardiometabolic biomarkers in high cardiovascular (CV) risk patients. The study included 226 subjects with high TG and ≥1 of the following CV risk factors: arterial hypertension, diabetes mellitus, ultrasound-documented atheromatosis, peripheral artery disease, previous myocardial infarction, or ischemic stroke...
February 21, 2024: Lipids
https://read.qxmd.com/read/38381282/targeting-lipoprotein-a-can-rna-therapeutics-provide-the-next-step-in-the-prevention-of-cardiovascular-disease
#37
REVIEW
Henriette Thau, Sebastian Neuber, Maximilian Y Emmert, Timo Z Nazari-Shafti
Numerous genetic and epidemiologic studies have demonstrated an association between elevated levels of lipoprotein(a) (Lp[a]) and cardiovascular disease. As a result, lowering Lp(a) levels is widely recognized as a promising strategy for reducing the risk of new-onset coronary heart disease, stroke, and heart failure. Lp(a) consists of a low-density lipoprotein-like particle with covalently linked apolipoprotein A (apo[a]) and apolipoprotein B-100, which explains its pro-thrombotic, pro-inflammatory, and pro-atherogenic properties...
February 21, 2024: Cardiology and Therapy
https://read.qxmd.com/read/38376674/-abeta-and-hypobeta-lipoproteinemia
#38
JOURNAL ARTICLE
Klaus G Parhofer
No abstract text is available yet for this article.
February 2024: MMW Fortschritte der Medizin
https://read.qxmd.com/read/38374759/letter-to-the-editor-alzheimer-s-disease-associated-apoe-%C3%AE%C2%B54-frequencies-in-indian-population-genomes-may-suggest-implications-in-lecanemab-treatment
#39
JOURNAL ARTICLE
B Jolly, V Scaria
No abstract text is available yet for this article.
2024: Journal of Prevention of Alzheimer's Disease
https://read.qxmd.com/read/38373707/numom2b-study-insights-primary-exposures-outcomes-and-directions-for-future-research
#40
JOURNAL ARTICLE
Leanna Kragenbrink, Claire M Schopper, Rebecca B McNeil, William A Grobman, Robert M Silver, David M Haas
OBJECTIVE:  To summarize the publications to date from a large obstetric cohort of nulliparous individuals. STUDY DESIGN:  We summarized all of the publications from the Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-be (nuMoM2b). We descriptively summarized the most common outcomes and exposures reported in current publications. RESULTS:  Fifty-six publications to date are discussed. The most common primary exposures reported are participant baseline characteristics such as body mass index (24%), sociodemographic characteristics (22%), and sleep factors (16%)...
February 19, 2024: American Journal of Perinatology
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