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https://www.readbyqxmd.com/read/29243749/association-between-berries-intake-and-cardiovascular-diseases-risk-factors-a-systematic-review-with-meta-analysis-and-trial-sequential-analysis-of-randomized-controlled-trials
#1
REVIEW
Ângelo Luís, Fernanda Domingues, Luísa Pereira
The main goal of this work was to clarify the effects of the consumption of berries on cardiovascular disease (CVD) risk factors by performing a systematic review according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) statement, followed by a meta-analysis and a trial sequential analysis (TSA) of randomized controlled trials (RCTs). The electronic search was conducted in PubMed, Scopus, SciELO, Web of Science and Cochrane Library between April and June 2016. To be included, RCTs had to report 1 or more of the following outcomes: total cholesterol (TC), HDL-cholesterol (HDL), LDL-cholesterol (LDL), triglycerides (TG), blood pressure (BP), C-reactive protein (CRP), tumour necrosis factor-α (TNF-α), interleukin-6 (IL-6), vascular cell adhesion molecule-1 (VCAM), intercellular adhesion molecule-1 (ICAM), glucose, insulin, apolipoprotein A-I (Apo A-I) or apolipoprotein B (Apo B)...
December 15, 2017: Food & Function
https://www.readbyqxmd.com/read/29243286/conformational-dynamics-of-human-protein-kinase-ck2%C3%AE-and-its-effect-on-function-and-inhibition
#2
Ashutosh Srivastava, Tsuyoshi Hirota, Stephan Irle, Florence Tama
Protein Kinase CK2 is ubiquitously expressed and highly conserved protein kinase that shows constitutive activity. It phosphorylates a diverse set of proteins and plays crucial role in several cellular processes. The catalytic subunit of this enzyme (CK2α) shows remarkable flexibility as evidenced in numerous crystal structures determined till now. Here, using analysis of multiple crystal structures and long timescale molecular dynamics simulations, we explore the conformational flexibility of CK2α. The enzyme shows considerably higher flexibility in the solution as compared to that observed in crystal structure ensemble...
December 15, 2017: Proteins
https://www.readbyqxmd.com/read/29241581/iron-induced-chelation-alleviates-the-potential-allergenicity-of-ovotransferrin-in-a-balb-c-mouse-model
#3
Ping Tong, Lin Gao, Jinyan Gao, Xin Li, Zhihua Wu, Anshu Yang, Hongbing Chen
Ovotransferrin (OVT) is one of the main egg allergens with 2 iron-binding sites. Several studies have demonstrated that iron-chelation decreased the allergenicity of milk allergen and birch pollen allergens. Therefore, we hypothesized that iron-chelation could also reduce the allergenicity of OVT. Apo-OVT (iron-free OVT, the natural state in egg white) and Holo-OVT (iron-chelated OVT) were prepared, and the allergenicity of them were assessed and compared using a BALB/c mouse model as well as dendritic cells (DCs) based on antigen uptake...
November 2017: Nutrition Research
https://www.readbyqxmd.com/read/29241386/modified-risk-associations-of-lipoproteins-and-apolipoproteins-by-chronic-low-grade-inflammation
#4
Altan Onat, Aysem Kaya, Evin Ademoglu
Lipoproteins and the apolipoproteins (apo) that they carry are major determinants of cardiovascular diseases (CVD) as well as metabolic, renal and inflammatory chronic disorders either directly or through mediation of risk factors. The notion that elevated low-density lipoprotein cholesterol (LDL-C) and apoB levels are related to the acquisition of CVD and, high-density lipoprotein cholesterol (HDL-C) and apoA-I indicate protection against CVD has been challenged in the past decade. Advanced age, adiposity, ethnicity or impaired glucose intolerance rendered autoimmune activation in an environment of pro-inflammatory state/oxidative stress and may disrupt the linear risk association between lipoproteins...
December 15, 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/29240800/effect-of-long-term-dietary-sphingomyelin-supplementation-on-atherosclerosis-in-mice
#5
Rosanna W S Chung, Zeneng Wang, Christina A Bursill, Ben J Wu, Philip J Barter, Kerry-Anne Rye
Sphingomyelin (SM) levels in the circulation correlate positively with atherosclerosis burden. SM is a ubiquitous component of human diets, but it is unclear if dietary SM increases circulating SM levels. Dietary choline increases atherosclerosis by raising circulating trimethylamine N-oxide (TMAO) levels in mice and humans. As SM has a choline head group, we ask in this study if dietary SM accelerates atherosclerotic lesion development by increasing circulating SM and TMAO levels. Three studies were performed: (Study 1) C57BL/6 mice were maintained on a high fat diet with or without SM supplementation for 4 weeks prior to quantification of serum TMAO and SM levels; (Study 2) atherosclerosis was studied in apoE-/- mice after 16 weeks of a high fat diet without or with SM supplementation and (Study 3) apoE-/- mice were maintained on a chow diet for 19 weeks without or with SM supplementation and antibiotic treatment prior to quantification of atherosclerotic lesions and serum TMAO and SM levels...
2017: PloS One
https://www.readbyqxmd.com/read/29240291/novel-4-amino-1-2-3-triazole-inhibitors-of-indoleamine-2-3-dioxygenase-form-a-long-lived-complex-with-the-enzyme-and-display-exquisite-cellular-potency
#6
Julie Alexandre, Michael Swan, Mike Latchem, Dean Boyall, John Pollard, Stuart Hughes, James Westcott
Indoleamine-2,3 dioxygenase (IDO) has emerged as a central regulator of immune responses in both normal and disease biology. Due to its established role in promoting tumour immune escape, IDO has become an attractive target for cancer treatment. We have identified a novel series of highly cell potent IDO inhibitors based on a 4-amino-1,2,3-triazole core. Comprehensive kinetic, biochemical and structural studies demonstrate that compounds from this series have a non-competitive kinetic mechanism-of-action with respect to the tryptophan substrate...
December 14, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/29234142/a-molecular-chaperone-activity-of-ccs-restores-the-maturation-of-sod1-fals-mutants
#7
Enrico Luchinat, Letizia Barbieri, Lucia Banci
Superoxide dismutase 1 (SOD1) is an important metalloprotein for cellular oxidative stress defence, that is mutated in familiar variants of Amyotrophic Lateral Sclerosis (fALS). Some mutations destabilize the apo protein, leading to the formation of misfolded, toxic species. The Copper Chaperone for SOD1 (CCS) transiently interacts with SOD1 and promotes its correct maturation by transferring copper and catalyzing disulfide bond formation. By in vitro and in-cell NMR, we investigated the role of the SOD-like domain of CCS (CCS-D2)...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29232010/protective-effect-of-hsp27-in-atherosclerosis-and-coronary-heart-disease-by-inhibiting-reactive-oxygen-species
#8
Hongli Zhang, Kaiying Jia, Da Sun, Min Yang
OBJECTIVE: To clarify the mechanism of HSP27 as a diagnostic biomarker in coronary heart disease (CHD) and atherosclerosis (AS). METHOD: Expressions of HSP27 in CHD patients and healthy controls were determined by ELISA, and expressions of HSP27 in aortas of CHD patients and healthy controls were measured by Immunohistochemistry. ROC curve was applied to assess the diagnostic performance of HSP27 in CHD. ApoE-/- mice were included and accordingly grouped. The expressions of HSP27 in AS plaque were measured by qRT-PCR, Immunohistochemistry and Western blot...
December 12, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29231996/molecular-mechanisms-of-tributyltin-induced-alterations-in-cholesterol-homeostasis-and-steroidogenesis-in-hamster-testis-in-vivo-and-in-vitro-studies
#9
V Kanimozhi, K Palanivel, M A Akbarsha, B Kadalmani
Tributyltins (TBT) are ubiquitous and persistent environmental contaminants that disturb normal endocrine function including gonadal function in humans and marine organisms. TBT was administered through oral route to male Syrian hamsters at daily doses of 50, 100 and 150 ppm/kg for 65 days. Changes in testis morphology, immunohistochemistry of iNOS, 3β-HSD and 17β-HSD, cholesterol transport receptor, nuclear receptors, and transcription factors were analyzed. TBT treatment affected each of these parameters to significant levels in a dose-dependent manner compared to vehicle treated control...
December 12, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29231984/evidence-for-increased-chylomicron-remnants-in-rheumatoid-arthritis
#10
Benjamin Burggraaf, Deborah F van Breukelen-van der Stoep, Jendé van Zeben, Noelle van der Meulen, Gert-Jan M van de Geijn, Anho Liem, Pedro Valdivielso, José Rioja Villodres, José Ramírez-Bollero, Ellen van der Zwan, Manuel Castro Cabezas
BACKGROUND: Levels of apolipoprotein (apo) B48 may be increased in conditions associated with systemic inflammation and increased cardiovascular disease (CVD) risk like rheumatoid arthritis (RA). We aimed to evaluate apo B48 levels in patients with RA in relation to subclinical atherosclerosis. METHODS: Patients with RA (without CVD) and controls without RA but with high CVD risk (based on the presence of diabetes mellitus or a history of CVD) and healthy controls, were included in this cross-sectional study...
December 12, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29230410/sera-from-visceral-leishmaniasis-patients-display-oxidative-activity-and-affect-the-tnf-%C3%AE-production-by-macrophages-in-vitro
#11
Neci M Soares, Joelma N de Souza, Tatiana F Leal, Eliana A G Reis, Maria S Miranda, Washington L C Dos Santos, Márcia C A Teixeira
Mammalian protection against leishmanial infection depends on the development of an effective immune response. Zoonotic visceral leishmaniasis (ZVL) patients are usually unable to mount an effective immune response against the parasite and indeed appear to be severely immunosuppressed. This suppression has strong nonspecific and specific components mediated by serum factors and leishmanicidal activity of infected macrophages, respectively. The lipid profile has been shown to be altered in ZVL patients' sera...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29229897/integrative-analysis-to-identify-common-genetic-markers-of-metabolic-syndrome-dementia-and-diabetes
#12
Weihong Zhang, Linlin Xin, Ying Lu
BACKGROUND Emerging data have established links between systemic metabolic dysfunction, such as diabetes and metabolic syndrome (MetS), with neurocognitive impairment, including dementia. The common gene signature and the associated signaling pathways of MetS, diabetes, and dementia have not been widely studied. MATERIAL AND METHODS We exploited the translational bioinformatics approach to choose the common gene signatures for both dementia and MetS. For this we employed "DisGeNET discovery platform". RESULTS Gene mining analysis revealed that a total of 173 genes (86 genes common to all three diseases) which comprised a proportion of 43% of the total genes associated with dementia...
December 12, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29229777/crystal-structure-of-the-flif-flig-complex-from-helicobacter-pylori-yields-insight-into-the-assembly-of-the-motor-ms-c-ring-in-the-bacterial-flagellum
#13
Chaolun Xue, Kwok Ho Lam, Huawei Zhang, Kailei Sun, Sai Hang Lee, Xin Chen, Shannon Wing Ngor Au
The bacterial flagellar motor is a self-assembling supramolecular nanodevice. Its spontaneous biosynthesis is initiated by the insertion of the MS ring protein FliF into the inner membrane, followed by attachment of the switch protein FliG. Assembly of this multiprotein complex is tightly regulated to avoid nonspecific aggregation, but the molecular mechanisms governing flagellar assembly are unclear. Here, we present the crystal structure of the cytoplasmic domain of FliF complexed with the N-terminal domain of FliG (FliFC-FliGN) from the bacterium Helicobacter pylori Within this complex, FliFC interacted with FliGN through extensive hydrophobic contacts similar to those observed in the FliFC-FliGN structure from the thermophile Thermotoga maritima, indicating conservation of the FliFC-FliGN interaction across bacterial species...
December 11, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29227739/chronic-exposure-to-external-low-dose-gamma-radiation-induces-an-increase-in-anti-inflammatory-and-anti-oxidative-parameters-resulting-in-atherosclerotic-plaque-size-reduction-in-apoe-mice
#14
T G Ebrahimian, L Beugnies, J Surette, N Priest, Y Gueguen, C Gloaguen, M Benderitter, J R Jourdain, K Tack
Populations living in radiation-contaminated territories, such as Chernobyl and Fukushima, are chronically exposed to external gamma radiation and internal radionuclide contamination due to the large amount of 137Cs released in the environment. The effect of chronic low-dose exposure on the development of cardiovascular diseases remains unclear. Previously reported studies have shown that low-dose radiation exposure could lead to discrepancies according to dose rate. In this study, we examined the effect of very low-dose and dose-rate chronic external exposure on atherosclerosis development...
December 11, 2017: Radiation Research
https://www.readbyqxmd.com/read/29226870/alzheimer-s-disease-progression-factors-influencing-cognitive-decline
#15
Camilla Ferrari, Gemma Lombardi, Cristina Polito, Giulia Lucidi, Silvia Bagnoli, Irene Piaceri, Benedetta Nacmias, Valentina Berti, Debora Rizzuto, Laura Fratiglioni, Sandro Sorbi
BACKGROUND: Alzheimer's disease (AD) patients present high variability in the rate of cognitive decline. Despite the wide knowledge on factors influencing dementia risk, little is known on what accounts for AD progression. Previous studies on this topic have mainly analyzed each factor separately without taking into account the interaction between genetic and non-genetic factors. OBJECTIVE: The aim of the present study is to evaluate the role of demographic, clinical, therapeutic, and genetic factors and their interaction on cognitive decline among newly diagnosed AD patients...
December 8, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29226146/heparanase-inhibition-reduces-glucose-levels-blood-pressure-and-oxidative-stress-in-apolipoprotein-e-knockout-mice
#16
Shadi Hamoud, Rabia Shekh Muhammad, Niroz Abu-Saleh, Ahmad Hassan, Yaniv Zohar, Tony Hayek
Background: Atherosclerosis is a multifactorial process. Emerging evidence highlights a role of the enzyme heparanase in various disease states, including atherosclerosis formation and progression. Objective: The aim of the study was to investigate the effect of heparanase inhibition on blood pressure, blood glucose levels, and oxidative stress in apoE-/- mice. Methods: Male apoE-/- mice were divided into two groups: one treated by the heparanase inhibitor PG545, administered intraperitoneally weekly for seven weeks, and the other serving as control group (injected with saline)...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29226138/effects-of-astaxanthin-on-reverse-cholesterol-transport-and-atherosclerosis-in-mice
#17
Tang-Bin Zou, Shan-Shan Zhu, Fei Luo, Wei-Qiao Li, Xue-Rong Sun, Hong-Fu Wu
High plasma level of HDL-cholesterol (HDL-C) has been consistently associated with a decreased risk of atherosclerosis (AS); thus, HDL-C is considered to be an antiatherogenic lipoprotein. The development of novel therapies to enhance the atheroprotective properties of HDL may have the possibility of further reducing the residual AS risk. Reverse cholesterol transport (RCT) is believed to be a primary atheroprotective activity of HDL, which has been shown to promote the efflux of excess cholesterol from macrophage-derived foam cells via ATP-binding cassette transporter A1 (ABCA1), ATP-binding cassette transporter G1 (ABCG1), and scavenger receptor class B type I (SR-BI) and then transport it back to the liver for excretion into bile and eventually into the feces...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29225168/cortistatin-attenuates-angiotensin-ii-induced-abdominal-aortic-aneurysm-through-inactivation-of-the-erk1-2-signaling-pathways
#18
Hao Chai, ZhongHao Tao, Wen Chen, YueYue Xu, Fuhua Huang, CunHua Su, Xin Chen
Abdominal aortic aneurysm (AAA) is a fatal disease that is associated with chronic inflammation in the vessel wall. Cortistatin is implicated in inflammation, vascular smooth muscle cell migration and other cardiovascular pathologies. But, the hypothetical effect of cortistatin on AAA remains uncertain. We investigated the effect of cortistatin administration to angiotensin (Ang) II-induced AAA formation in apolipoprotein E deficient (Apoe-/-) mice. We showed that cortistatin administration significantly suppresses incidence and severity of AAA in Apoe-/- mice...
December 7, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29224353/curcumin-attenuates-atherosclerosis-in-apolipoprotein-e-knockout-mice-by-inhibiting-toll-like-receptor-4-expression
#19
Shanshan Zhang, Jun Zou, Peiyang Li, Xiumei Zheng, Dan Feng
Toll-like receptor 4 (TLR4) has been reported to play a critical role in the pathogenesis of atherosclerosis, the current study aimed to investigate whether curcumin suppresses atherosclerosis development in ApoE-knockout (ApoE-/-) mice by inhibiting TLR4 expression. ApoE-/- mice were fed a high-fat diet supplemented with or without curcumin (0.1% w/w) for 16 weeks. Curcumin supplementation significantly reduced TLR4 expression and macrophage infiltration in atherosclerotic plaques. Curcumin also reduced aortic interleukin-1β (IL-1β), tumour necrosis factor-α (TNF-α), vascular cell adhesion molecule -1(VCAM-1) and intercellular adhesion molecule- 1(ICAM-1) expression, nuclear factor-κB (NF-κB) activity, and plasma IL-1β, TNF-α, soluble VCAM-1 and ICAM-1 levels...
December 10, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29222858/obesity-lipid-profiles-and-oxidative-stress-in-children-after-liver-transplantation
#20
Piotr Czubkowski, Aldona Wierzbicka, Joanna Pawłowska, Irena Jankowska, Piotr Socha
PURPOSE: In adult liver transplant recipients, coronary artery disease and congestive heart failure are significant cause of morbidity and mortality. This may be attributed to the long-term immunosuppressive treatment, mostly with calcineurin inhibitors and steroids, which in long-term may be associated with hyperlipidemia, oxidative stress and cardiovascular complications. Since such data for children is sparse, the aim of this study was to assess the lipid and oxidative stress markers after pediatric liver transplantation (LTx)...
December 10, 2017: Acta Biochimica Polonica
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