Noah G Schwartz, Alfonso C Hernandez-Romieu, Pallavi Annambhotla, Thomas D Filardo, Sandy P Althomsons, Rebecca J Free, Ruoran Li, W Wyatt Wilson, Molly Deutsch-Feldman, Marci Drees, Emily Hanlin, Kelly White, Kimberly A Lehman, Tyler C Thacker, Scott A Brubaker, Brychan Clark, Sridhar V Basavaraju, Isaac Benowitz, Janet Burton Glowicz, Lauren S Cowan, Angela M Starks, Sapna Bamrah Morris, Philip LoBue, Rebekah J Stewart, Jonathan M Wortham, Maryam B Haddad
BACKGROUND: Mycobacterium tuberculosis transmission through solid organ transplantation has been well described, but transmission through transplanted tissues is rare. We investigated a tuberculosis outbreak in the USA linked to a bone graft product containing live cells derived from a single deceased donor. METHODS: In this outbreak report, we describe the management and severity of the outbreak and identify opportunities to improve tissue transplant safety in the USA...
November 2022: Lancet Infectious Diseases