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https://www.readbyqxmd.com/read/27911485/effects-of-the-presence-of-grazing-experienced-heifers-on-the-development-of-foraging-behavior-at-the-feeding-station-scale-for-first-grazing-season-calves
#1
Yuko Shingu, Koichiro Ueda, Shingo Tada, Tomohiro Mitani, Seiji Kondo
In this study, effects of grazing-experienced heifer presence on foraging behavior development at the feeding station (FS) scale for first-grazing season calves were determined. A group of four calves grazing alone (C), and another comprising four calves (Wc) and three grazing-experienced heifers (Wh), were alternately stocked every day for 2 h on the same pasture for 26 days. The foraging time budget for Wc was significantly longer than that for C (P < 0.05) on day 7, and was similar to that for Wh on all days...
December 2, 2016: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/27869347/myb-transcription-factor-gene-involved-in-sex-determination-in-asparagus-officinalis
#2
Kohji Murase, Shuji Shigenobu, Sota Fujii, Kazuki Ueda, Takanori Murata, Ai Sakamoto, Yuko Wada, Katsushi Yamaguchi, Yuriko Osakabe, Keishi Osakabe, Akira Kanno, Yukio Ozaki, Seiji Takayama
Dioecy is a plant mating system in which individuals of a species are either male or female. Although many flowering plants evolved independently from hermaphroditism to dioecy, the molecular mechanism underlying this transition remains largely unknown. Sex determination in the dioecious plant Asparagus officinalis is controlled by X and Y chromosomes; the male and female karyotypes are XY and XX, respectively. Transcriptome analysis of A. officinalis buds showed that a MYB-like gene, Male Specific Expression 1 (MSE1), is specifically expressed in males...
November 21, 2016: Genes to Cells: Devoted to Molecular & Cellular Mechanisms
https://www.readbyqxmd.com/read/27521999/corrigendum-to-telmisartan-inhibits-age-induced-podocyte-damage-and-detachment-microvascular-research-88-2013-79-83
#3
Kei Fukami, Sho-Ichi Yamagishi, Kumiko Kaifu, Takanori Matsui, Yusuke Kaida, Seiji Ueda, Masayoshi Takeuchi, Katsuhiko Asanuma, Seiya Okuda
No abstract text is available yet for this article.
August 10, 2016: Microvascular Research
https://www.readbyqxmd.com/read/27434533/molecular-genetic-analysis-of-30-families-with-joubert-syndrome
#4
T Suzuki, N Miyake, Y Tsurusaki, N Okamoto, A Alkindy, A Inaba, M Sato, S Ito, K Muramatsu, S Kimura, D Ieda, S Saitoh, M Hiyane, H Suzumura, K Yagyu, H Shiraishi, M Nakajima, N Fueki, Y Habata, Y Ueda, Y Komatsu, K Yan, K Shimoda, Y Shitara, S Mizuno, K Ichinomiya, K Sameshima, Y Tsuyusaki, K Kurosawa, Y Sakai, K Haginoya, Y Kobayashi, C Yoshizawa, M Hisano, M Nakashima, H Saitsu, S Takeda, N Matsumoto
Joubert syndrome (JS) is rare recessive disorders characterized by the combination of hypoplasia/aplasia of the cerebellar vermis, thickened and elongated superior cerebellar peduncles, and a deep interpeduncular fossa which is defined by neuroimaging and is termed the 'molar tooth sign'. JS is genetically highly heterogeneous, with at least 29 disease genes being involved. To further understand the genetic causes of JS, we performed whole-exome sequencing in 24 newly recruited JS families. Together with six previously reported families, we identified causative mutations in 25 out of 30 (24 + 6) families (83...
July 19, 2016: Clinical Genetics
https://www.readbyqxmd.com/read/27419047/a-comparative-proteomics-study-of-a-synovial-cell-line-stimulated-with-tnf-%C3%AE
#5
Seiji Shibasaki, Miki Karasaki, Shunsuke Aburaya, Hironobu Morisaka, Yumiko Takeda, Wataru Aoki, Sachie Kitano, Masayasu Kitano, Mitsuyoshi Ueda, Hajime Sano, Tsuyoshi Iwasaki
To elucidate the pathogenesis of rheumatoid arthritis (RA), we used proteomic analysis to determine the protein profile in a synovial cell line, MH7A, established from patients with RA. Proteins were extracted from MH7A cells that were or were not stimulated with tumor necrosis factor-α (TNF-α), and then analyzed on a liquid chromatography/mass spectrometry system equipped with a unique long monolithic silica capillary. On the basis of the results of this proteomic analysis, we identified 2650 proteins from untreated MH7A cells and 2688 proteins from MH7A cells stimulated with TNF-α...
May 2016: FEBS Open Bio
https://www.readbyqxmd.com/read/27342839/dose-volume-analysis-of-predictors-for-chronic-gastrointestinal-complications-in-patients-with-cervical-cancer-treated-with-postoperative-concurrent-chemotherapy-and-whole-pelvic-radiation-therapy
#6
Fumiaki Isohashi, Seiji Mabuchi, Yuichi Akino, Yasuo Yoshioka, Yuji Seo, Osamu Suzuki, Keisuke Tamari, Kiyoshi Yoshino, Kenjiro Sawada, Yutaka Ueda, Eiji Kobayashi, Iori Sumida, Hirokazu Mizuno, Hirofumi Okubo, Tadashi Kimura, Kazuhiko Ogawa
The purpose of this study is to evaluate dose-volume histogram (DVH) predictors for the development of chronic gastrointestinal (GI) complications in patients with cervical cancer who have undergone postoperative concurrent chemotherapy and whole-pelvic radiation therapy (WPRT). The subjects were 135 patients who had undergone postoperative WPRT with concurrent nedaplatin-based chemotherapy between 2000 and 2014. Associations between selected DVH parameters and the incidence of chronic GI complications of G3 or higher were evaluated...
November 2016: Journal of Radiation Research
https://www.readbyqxmd.com/read/27332769/clinical-and-genetic-features-of-patients-with-tnfrsf1a-variants-in-japan-findings-of-a-nationwide-survey
#7
Naoyasu Ueda, Hiroaki Ida, Masakazu Washio, Hisaaki Miyahara, Shoji Tokunaga, Fumiko Tanaka, Hiroki Takahashi, Koichi Kusuhara, Koichiro Ohmura, Manabu Nakayama, Osamu Ohara, Ryuta Nishikomori, Seiji Minota, Shuji Takei, Takao Fujii, Yoshiaki Ishigatsubo, Hiroshi Tsukamoto, Tomoko Tahira, Takahiko Horiuchi
Objectives A nationwide survey was conducted to elucidate the clinical and genetic features of patients with TNFRSF1A variants in Japan. Methods Inquiries were sent to 2,900 departments of internal medicine and pediatrics in all the hospitals with over 200 beds in Japan, asking whether they had patients suspected of having tumor necrosis factor receptor-associated periodic syndrome (TRAPS). Genetic tests for TNFRSF1A, MEFV, and MVK were performed on 169 patients. Cell surface expression of TNFRSF1A variants was assessed using 293T cells...
June 22, 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/27284446/single-dose-intra-arterial-neoadjuvant-chemotherapy-while-waiting-for-radical-hysterectomy-for-stage-ib-iib-cervical-cancer
#8
Kiyoshi Yoshino, Ayako Hosoi, Keigo Osuga, Takayuki Enomoto, Yutaka Ueda, Kenjiro Sawada, Seiji Mabuchi, Eiji Kobayashi, Koji Matsuo, Tadashi Kimura
Extended wait time prior to initial surgery may increase patients' anxiety. Therefore, patients may opt to receive other available treatments to inhibit tumor growth until surgery. This retrospective study describes our experience with single-dose intra-arterial neoadjuvant chemotherapy (IANAC) to more effectively utilize the wait time prior to radical hysterectomy. A total of 12 patients with International Federation of Gynecology and Obstetrics stage IB1-IIB cervical cancer were treated with single-dose IANAC prior to radical hysterectomy...
June 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/27245065/a-cross-sectional-investigation-of-cancer-screening-intentions-sources-of-information-and-understanding-of-cancer-in-japanese-adolescents
#9
Koshu Sugisaki, Seiji Ueda, Masaru Ueji, Hirofumi Monobe, Hiroko Yako-Suketomo, Takashi Eto, Masaki Watanabe, Ryoichi Mori
The purpose of this study was to describe the cancer-screening intention, sources of cancer information, and cancer understanding among Japanese adolescents. A cross-sectional nationwide survey involving a self-administered questionnaire was conducted. Response rates of the target schools were 46.4 % (n = 103) for junior high schools and 55.8 % (n = 116) for high schools. From these, we analyzed the data of 2960 junior high school students (1520 males, 1440 females) and 3703 high school students (1546 males, 2157 females) to examine the association between cancer-screening intention and sources of cancer-related information and understanding...
June 1, 2016: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/27181332/bcr-abl-specific-cd4-t-helper-cells-promote-the-priming-of-antigen-specific-cytotoxic-t-cells-via-dendritic-cells
#10
Norihiro Ueda, Rong Zhang, Minako Tatsumi, Tian-Yi Liu, Shuichi Kitayama, Yutaka Yasui, Shiori Sugai, Tatsuaki Iwama, Satoru Senju, Seiji Okada, Tetsuya Nakatsura, Kiyotaka Kuzushima, Hitoshi Kiyoi, Tomoki Naoe, Shin Kaneko, Yasushi Uemura
The advent of tyrosine kinase inhibitor (TKI) therapy markedly improved the outcome of patients with chronic-phase chronic myeloid leukemia (CML). However, the poor prognosis of patients with advanced-phase CML and the lifelong dependency on TKIs are remaining challenges; therefore, an effective therapeutic has been sought. The BCR-ABL p210 fusion protein's junction region represents a leukemia-specific neoantigen and is thus an attractive target for antigen-specific T-cell immunotherapy. BCR-ABL p210 fusion-region-specific CD4(+) T-helper (Th) cells possess antileukemic potential, but their function remains unclear...
May 16, 2016: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/27179663/maternal-exposure-to-high-fat-and-high-fructose-diet-evokes-hypoadiponectinemia-and-kidney-injury-in-rat-offspring
#11
Nana Yamada-Obara, Sho-Ichi Yamagishi, Kensei Taguchi, Yusuke Kaida, Miyuki Yokoro, Yosuke Nakayama, Ryotaro Ando, Katsuhiko Asanuma, Takanori Matsui, Seiji Ueda, Seiya Okuda, Kei Fukami
BACKGROUND: Maternal exposure to overnutrition during fetal development contributes to metabolic and renal damage in offspring. Adiponectin plays a protective role against obesity-related renal injury. However, role of adiponectin in renal injury of offspring exposed to maternal overnutrition remains unknown. We addressed the issue. METHODS: Female Sprague-Dawley rats were fed either a standard (N) or a high-fat and high-fructose (HFF)-diet for 6 weeks before mating, and kept each diet during the gestation and lactation period...
December 2016: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/27145745/effect-of-timing-and-type-of-supplementary-grain-on-herbage-intake-nitrogen-utilization-and-milk-production-in-dairy-cows-grazed-on-perennial-ryegrass-pasture-from-evening-to-morning
#12
Koichiro Ueda, Tomohiro Mitani, Seiji Kondo
The present study aimed to clarify the effect of timing and type of supplementary grain in grazing dairy cows on herbage dry matter intake (HDMI), nitrogen utilization and milk production. Eight lactating cows were allowed to graze from evening to morning during three seasonal periods (spring, summer, autumn). They were randomly allocated to four treatments (timing: pre- (Pre) or post-grazing (Post), for large grain allotments consisting of 75% of daily grain offered; grain type: barley or corn) in 4 × 4 Latin square designs in each period...
May 5, 2016: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/27083282/the-dipeptidyl-peptidase-inhibitor-linagliptin-and-the-angiotensin-ii-receptor-blocker-telmisartan-show-renal-benefit-by-different-pathways-in-rats-with-5-6-nephrectomy
#13
Oleg Tsuprykov, Ryotaro Ando, Christoph Reichetzeder, Karoline von Websky, Viktoriia Antonenko, Yuliya Sharkovska, Lyubov Chaykovska, Jan Rahnenführer, Ahmed A Hasan, Harald Tammen, Markus Alter, Thomas Klein, Seiji Ueda, Sho-Ichi Yamagishi, Seiya Okuda, Berthold Hocher
Dipeptidyl peptidase (DPP)-4 inhibitors delay chronic kidney disease (CKD) progression in experimental diabetic nephropathy in a glucose-independent manner. Here we compared the effects of the DPP-4 inhibitor linagliptin versus telmisartan in preventing CKD progression in non-diabetic rats with 5/6 nephrectomy. Animals were allocated to 1 of 4 groups: sham operated plus placebo; 5/6 nephrectomy plus placebo; 5/6 nephrectomy plus linagliptin; and 5/6 nephrectomy plus telmisartan. Interstitial fibrosis was significantly decreased by 48% with linagliptin but a non-significant 24% with telmisartan versus placebo...
May 2016: Kidney International
https://www.readbyqxmd.com/read/27076318/oral-vaccine-development-by-molecular-display-methods-using-microbial-cells
#14
Seiji Shibasaki, Mitsuyoshi Ueda
Oral vaccines are easier to administer than injectable vaccines. To induce an adequate immune response using vaccines, antigenic proteins are usually combined with adjuvant materials. This chapter presents methodologies for the design of oral vaccines using molecular display technology. In molecular display technology, antigenic proteins are displayed on a microbial cell surface with adjuvant ability. This technology would provide a quite convenient process to produce oral vaccines when the DNA sequence of an efficient antigenic protein is available...
2016: Methods in Molecular Biology
https://www.readbyqxmd.com/read/26935367/prosthetic-valve-dysfunction-35-years-after-mitral-valve-replacement-with-a-starr-edwards-caged-disc-valve
#15
Tetsuro Yokokawa, Takahiro Ohara, Seiji Takashio, Mari Sakamoto, Yuko Wada, Kenji Nakamura, Hiroyuki Takahama, Makoto Amaki, Takuya Hasegawa, Yasuo Sugano, Hideaki Kanzaki, Satoshi Yasuda, Hisao Ogawa, Tomoyuki Fujita, Junjiro Kobayashi, Yoko Okamoto, Taka-Aki Matsuyama, Hatsue Ishibashi-Ueda, Toshihisa Anzai
A 49-year-old man was admitted to our hospital with a chief complaint of dyspnea. He had a history of mitral valve replacement (MVR) with a Starr-Edwards (SE) caged-disc valve at the age of 14. Echocardiography revealed elevated trans-valvular pressure gradient of the mitral prosthetic valve with neither disk motion abnormality nor abnormal structure. Catheterization confirmed an elevation of the mean diastolic gradient of the mitral valve to 12.3 mmHg. Re-MVR was performed, and abnormal tissue attached to the cage of the valve and proliferating beneath the valve was observed...
2016: Internal Medicine
https://www.readbyqxmd.com/read/26920606/addition-of-cilostazol-to-aspirin-therapy-for-secondary-prevention-of-cardiovascular-and-cerebrovascular-disease-in-patients-undergoing-percutaneous-coronary-intervention-a-randomized-open-label-trial
#16
RANDOMIZED CONTROLLED TRIAL
Hiroshi Ueda, Atsumichi Kido, Seiji Matsuhisa, Koichiro Asawa, Naohiro Yoshida, Mitsuru Tsujimoto, Yasushi Sasaki, Yukiko Kuga, Masaki Yamasaki, Kazuya Ueda, Shoichi Shinohara, Yasunori Nishida
BACKGROUND: Patients with established coronary artery disease are at increased risk for future ischemic events and require secondary prevention for systemic vascular disease. We performed a randomized clinical trial to evaluate the impact of cilostazol on cardiovascular and cerebrovascular disease in patients undergoing percutaneous coronary intervention. METHODS: A total of 514 patients who had undergone coronary stent implantation >6 months previously and were thought to no longer need dual antiplatelet therapy with aspirin and a thienopyridine were randomly assigned to receive aspirin plus cilostazol therapy or aspirin therapy alone after discontinuation of thienopyridine therapy...
March 2016: American Heart Journal
https://www.readbyqxmd.com/read/26895603/drinking-behavior-and-mental-illness-among-evacuees-in-fukushima-following-the-great-east-japan-earthquake-the-fukushima-health-management-survey
#17
Yuka Ueda, Hirooki Yabe, Masaharu Maeda, Tetsuya Ohira, Senta Fujii, Shin-ichi Niwa, Akira Ohtsuru, Hirobumi Mashiko, Mayumi Harigane, Seiji Yasumura
BACKGROUND: Recent evidence from alcohol and trauma studies suggests that disasters are associated with increases in the consumption of alcohol. The Great East Japan Earthquake and the associated nuclear disaster have continued to affect the mental health of evacuees from Fukushima. This study aimed to extend these findings by examining the relationship between drinking behaviors and the risk of mental illness after the compound disaster. METHODS: We conducted the Mental Health and Lifestyle Survey with 56,543 evacuees...
March 2016: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/26879069/comparison-of-the-effect-of-rosuvastatin-2-5-mg-vs-20-mg-on-coronary-plaque-determined-by-angioscopy-and-intravascular-ultrasound-in-japanese-with-stable-angina-pectoris-from-the-aggressive-lipid-lowering-treatment-approach-using-intensive-rosuvastatin-for
#18
RANDOMIZED CONTROLLED TRIAL
Tadateru Takayama, Sei Komatsu, Yasunori Ueda, Seiji Fukushima, Takafumi Hiro, Atsushi Hirayama, Satoshi Saito
Diminishing yellow color, evaluated by coronary angioscopy, is associated with plaque stabilization and regression. Our aim was to assess the effect of aggressive lipid-lowering therapy with rosuvastatin on plaque regression and instability. Thirty-seven patients with stable angina or silent myocardial ischemia who planned to undergo elective percutaneous coronary intervention and had angioscopic yellow plaques of grade 2 or more were randomized to high-dose (group H, 20 mg/day, n = 18) or low-dose (group L, 2...
April 15, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/26849892/accurate-estimation-of-protein-creatinine-ratio-on-urine-sample-in-ckd-patients
#19
Kensei Taguchi, Seiji Ueda, Kei Fukami
No abstract text is available yet for this article.
June 2016: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/26845691/a-development-of-nucleic-chromatin-measurements-as-a-new-prognostic-marker-for-severe-chronic-heart-failure
#20
Machiko Kanzaki, Yoshihiro Asano, Hatsue Ishibashi-Ueda, Eiji Oiki, Tomoki Nishida, Hiroshi Asanuma, Hisakazu Kato, Toru Oka, Tomohito Ohtani, Osamu Tsukamoto, Shuichiro Higo, Hidetaka Kioka, Ken Matsuoka, Yoshiki Sawa, Issei Komuro, Masafumi Kitakaze, Seiji Takashima, Yasushi Sakata
BACKGROUND: Accurate prediction of both mortality and morbidity is of significant importance, but it is challenging in patients with severe heart failure. It is especially difficult to detect the optimal time for implanting mechanical circulatory support devices in such patients. We aimed to analyze the morphometric ultrastructure of nuclear chromatin in cardiomyocytes by developing an original clinical histopathological method. Using this method, we developed a biomarker to predict poor outcome in patients with dilated cardiomyopathy (DCM)...
2016: PloS One
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