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https://www.readbyqxmd.com/read/28107523/look-into-the-hiv-epidemic-of-gay-community-with-a-socio-cultural-perspective-a-qualitative-study-in-china-2015-2016
#1
Huijing He, Fan Lv, Nanci Nanyi Zhang, Zunyou Wu, Qinghua Liao, Zhanjun Chang, Yi Li, Huifang Xu, Lin OuYang, Xiping Huan, Juan Yang
BACKGROUND: Current Chinese studies continue to view male homosexuality through a disease focused lens which pays limited attention to socio-cultural aspects of sexual behavior and HIV transmission. This qualitative study aimed to investigate how socio-cultural factors influence gay men's sexual beliefs and behaviors in contemporary China, and their implications for HIV epidemic. METHODS AND FINDINGS: Qualitative methodology was used in this study. During 2015-2016, in-depth interviews were conducted with 61 self identified gay men in Jiangxi, Henan, Heilongjiang, Guangdong, Jiangsu provinces and Chongqing municipality of China...
2017: PloS One
https://www.readbyqxmd.com/read/28100377/-comparison-of-human-papilloma-virus-infection-status-between-men-who-have-sex-with-men-recruited-from-gay-bathhouses-and-hiv-voluntary-counseling-and-testing-clinics-respectively-in-urumqi
#2
T Tian, A J Cai, B X Huang, Ainiwaer Abidan, H Wang, J H Dai
Objective: To understand the human papilloma virus (HPV) infection status in men who have sex with men (MSM) recruited from gay bathhouses and HIV voluntary counseling and testing (VCT) clinics in Urumqi, Xinjiang Uygur autonomous region, and identify the associated risk factors. Methods: A total of 200 MSM aged ≥18 years were recruited by using the " snowballing" sampling method from gay bathhouses and VCT clinics in Urumqi during March-May, 2016. The MSM recruited completed questionnaires after filling in the informed consent form...
January 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28099753/correlation-between-rapid-hiv-testing-and-fourth-generation-elisa-results-for-hiv-detection-among-pregnant-patients-in-the-delivery-room
#3
Alejandro G Almaguer, Lidia Mendoza-Flores, Luis A Sánchez-López, Laura A Palau-Dávila, Magaly Padilla-Orozco, Adrián Camacho-Ortiz
OBJECTIVE: To analyze the usefulness of rapid HIV testing in pregnant patients in the delivery room. METHODS: This prospective study compared a rapid test and a fourth-generation enzyme-linked immunoassay (ELISA) for HIV screening among pregnant patients admitted in labor with an unknown HIV status at a university hospital in Mexico between July 2015 and February 2016. Pearson correlation analysis was performed, and the diagnostic accuracy of the two tests was assessed with HIV RNA polymerase chain reaction (PCR) as the reference method...
January 5, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28098042/-joining-forces-for-quality-improvement-in-tuberculosis-control
#4
L Gil, M J T van de Ven, C Richter
The incidence of tuberculosis (TB) in the Netherlands is declining every year. We fear there may be a loss of knowledge and awareness of detecting TB in the new generation of medical specialists. As medical specialists a great challenge lies before us in maintaining the quality of TB control in the Netherlands. Collaboration between pulmonologist, infectious disease specialist, microbiologist and the public health services is a necessity. Here we describe how, in the region of Arnhem, we work closely with these medical specialists based on structural multidisciplinary meetings...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28092853/operative-vaginal-delivery-and-invasive-procedures-in-pregnancy-among-women-living-with-hiv
#5
Helen Peters, Kate Francis, Kate Harding, Pat A Tookey, Claire Thorne
OBJECTIVES: To describe the use and outcomes of operative delivery and invasive procedures in pregnancy amongst women living with HIV. STUDY DESIGN: The National Study of HIV in Pregnancy and Childhood (NSHPC) is a comprehensive population-based surveillance study in the UK and Ireland. The NSHPC has collected data on operative delivery since 2008, and invasive procedures in pregnancy (amniocentesis, cordocentesis, chorionic villus sampling) from 2012. Descriptive analyses were conducted on 278 pregnancies expected to deliver from 1 January 2008 with outcome reported to the NSHPC by 31 March 2016...
December 24, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28091416/factors-associated-with-the-size-of-hiv-dna-reservoir
#6
REVIEW
Ni-Dan Wang, Tai-Sheng Li
OBJECTIVE: To review the recent literatures related to the factors associated with the size of the HIV reservoir and their clinical significance. DATA SOURCES: Literatures related to the size of HIV DNA was collected from PubMed published from 1999 to June 2016. STUDY SELECTION: All relevant articles on the HIV DNA and reservoir were collected and reviewed, with no limitation of study design. RESULTS: The composition and development of the HIV-1 DNA reservoir in either treated or untreated patients is determined by integrated mechanism comprising viral characteristics, immune system, and treatment strategies...
2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28090819/toxoplasmic-encephalitis-relapse-rates-with-pyrimethamine-based-therapy-systematic-review-and-meta-analysis
#7
Mark P Connolly, Elizabeth Goodwin, Carina Schey, Jacqueline Zummo
Toxoplasmic encephalitis (TE) is caused by Toxoplasma gondii infection and can be a life-threatening disease in immunocompromised patients. This study evaluated the rate of relapse associated with pyrimethamine-based maintenance therapy (i.e. secondary prophylaxis) in patients with human immunodeficiency virus (HIV) or AIDs treated prior to and after the common use (i.e. 1996) of highly active antiretroviral therapy (HAART) (pre-HAART and post-HAART, respectively). PubMed, Google Scholar, and Cochrane databases were searched to 6 June 2016 using search terms: pyrimethamine, Daraprim, Fansidar, Metakelfin, Fansimef, 5-(4-chlorophenyl)-6-ethyl-2,4-pyrimidinediamine, encephalitis, cerebral, toxoplasmosis, toxoplasmic, and gondii...
January 16, 2017: Pathogens and Global Health
https://www.readbyqxmd.com/read/28088905/update-on-recent-developments-in-small-molecular-hiv-1-rnase-h-inhibitors-2013-2016-opportunities-and-challenges
#8
Xueshun Wang, Ping Gao, Luis Menéndez-Arias, Xinyong Liu, Peng Zhan
Combinations of antiretroviral drugs are successfully used to treat HIV-infected patients. However, drug resistance is a major problem that makes discovery of new antiretroviral drugs an ongoing priority. The ribonuclease H (RNase H) activity of the HIV-1 reverse transcriptase catalyzes the selective hydrolysis of the RNA strand of RNA:DNA heteroduplex replication intermediates, and represents an attractive unexploited target for drug development. This review reports on recent progress in the characterization of HIV-1 RNase H inhibitors from 2013 to 2016, describing their chemical structures, structure-activity relationship and binding modes...
January 13, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28088237/association-between-diabetes-mellitus-and-multi-drug-resistant-tuberculosis-a-protocol-for-a-systematic-review-and-meta-analysis
#9
Balewgizie Sileshi Tegegne, Tesfa Dejenie Habtewold, Melkamu Merid Mengesha, Johannes G M Burgerhof
INTRODUCTION: Multi-drug-resistant tuberculosis (MDR-TB) has emerged as a challenge to global tuberculosis (TB) control and remains a major public health concern in many countries. Diabetes mellitus (DM) is an increasingly recognized comorbidity that can both accelerate TB disease and complicate its treatment. The aim of this study is to summarize available evidence on the association of DM and MDR-TB among TB patients and to provide a pooled estimate of risks. METHODS: All studies published in English before October 2016 will be searched using comprehensive search strings through PubMed, EMBASE, Web of Science, and WHO Global Health Library databases which have reported the association of DM and MDR-TB in adults with TB (age > =15)...
January 14, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28074746/oncology-s-trojan-horse-using-viruses-to-battle-cancer
#10
Heena J Mavani, Jeannette Y Wick
: In 2016, the American health care system was faced with more than 1.6 million new cases of cancer, and individuals older than 65 years of age will be affected disproportionately. Many older individuals are poor candidates for traditional treatments (e.g., chemotherapy, radiation) because of actual or potential treatment-related adverse events. Researchers continuously look for novel therapeutic strategies, and an exciting new one is on the horizon: virotherapy. Viruses' ability to infect and kill human cells makes them promising cancer treatments...
December 1, 2016: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://www.readbyqxmd.com/read/28074214/-buschke-lowenstein-tumors
#11
REVIEW
M Sporkert, A Rübben
BACKGROUND: A giant condyloma acuminatum which shows destructive growth but lacking invasion is designated as a Buschke-Lowenstein tumor (BLT). OBJECTIVES: Classification of the BLT and therapeutic guidelines are provided. MATERIALS AND METHODS: A MEDLINE literature search from 2006-2016 was performed. RESULTS: Induction through low-risk mucosotropic human papillomavirus (HPV) infection separates BLT from verrucous carcinoma...
January 10, 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/28070175/a-special-meeting-review-edition-advances-in-the-treatment-of-hepatitis-c-virus-infection-from-the-2016-easl-meeting-the-annual-meeting-of-the-european-association-for-the-study-of-the-liver-%C3%A2-april-13-17-2016-%C3%A2-barcelona-spainspecial-reporting-on-%C3%A2-six-weeks
#12
https://www.readbyqxmd.com/read/28068886/expertise-or-ideology-a-response-to-morris-et-al-2016-circumcision-is-a-primary-preventive-against-hiv-infection-critique-of-a-contrary-meta-regression-analysis-by-van-howe
#13
https://www.readbyqxmd.com/read/28067535/long-term-survival-of-aids-patients-treated-with-only-traditional-chinese-medicine
#14
Yifei Wang, Fujun Jin, Qiaoli Wang, Zucai Suo
Traditional Chinese herbal medicine (TCM) has been used in Chinese society for more than 5,000 years to treat diseases from inflammation to cancer. Here, we report the case of nine living AIDS patients in the age range of 51 to 67 who were treated with either a unique formula of TCM alone from 2001 to 2009 or the TCM from 2001 to 2006 and then switched to occasional antiretroviral therapy. Surprisingly, the viral loads of eight patients were at undetectable levels on June 28, 2016 while the remaining patient had a low viral load of 29 copies/ml...
January 9, 2017: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/28063074/prevention-of-mother-to-child-transmission-of-hiv-and-paediatric-hiv-care-and-treatment-monitoring-from-measuring-process-to-impact-and-elimination-of-mother-to-child-transmission-of-hiv
#15
Priscilla Idele, Chika Hayashi, Tyler Porth, Awandha Mamahit, Mary Mahy
Progress towards achievement of global targets for the prevention of mother-to-child transmission of HIV (PMTCT) and paediatric HIV care and treatment is an integral part of global and national HIV and AIDS responses. This paper documents the development of the global and national monitoring and reporting systems for PMTCT and paediatric HIV care and treatment programmes, achievements and remaining challenges. A review of the development of the monitoring and reporting process since 2002-2016 was conducted using existing published literature and taking into account changes in WHO HIV treatment guidelines, global HIV goals and targets, programmatic and methodological developments, and increased need for interagency partnerships, coordination and harmonization of global monitoring and reporting mechanisms...
January 6, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28062734/the-performance-of-the-alere-hiv-combo-point-of-care-test-on-stored-serum-samples-useful-for-detection-of-early-hiv-1-infections
#16
Carla van Tienen, Sharona Rugebregt, Sandra Scherbeijn, Hannelore Götz, Corine Geurts van Kessel
INTRODUCTION: The Alere HIV-1/2 Antigen/Antibody Combo point-of-care test is a commercially available 4th-generation rapid test for the diagnosis of HIV infection, including acute infection. We evaluated the sensitivity of this test in samples from patients with acute, recent or chronic HIV-1 infection. METHODS: A validation of the test was performed using 89 HIV-positive serum samples collected in 2008-2016, that were stored at -20°C. Twenty-three samples were only p24-positive (acute infection); 49 samples were antibody-positive and p24-positive (recent infection); 17 samples were only antibody-positive (chronic infection)...
January 6, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28060965/the-clinical-research-landscape-in-rhode-island
#17
George Mao, Bharat Ramratnam
OBJECTIVES: To present an overview of clinical research activity and the state of medical research funding in Rhode Island. METHODS: We utilized clinicaltrials.gov registry to profile clinical studies between 2011 to 2016. NIH RePORT and other federal databases were used to extract information on levels of federal funding. Previously published hospital financial reports were reviewed for data on hospital-specific total external research funding. RESULTS: During 2011-2016, 1651 clinical studies were registered in clinicaltrials...
January 6, 2017: Rhode Island Medical Journal
https://www.readbyqxmd.com/read/28051087/effects-of-depot-medroxyprogesterone-acetate-on-the-immune-microenvironment-of-the-human-cervix-and-endometrium-implications-for-hiv-susceptibility
#18
K K Smith-McCune, J F Hilton, U Shanmugasundaram, J W Critchfield, R M Greenblatt, D Seidman, S Averbach, L C Giudice, B L Shacklett
Depot-medroxyprogesterone acetate is a commonly used injectable contraceptive that has been associated with an increased risk of HIV acquisition. This study compares effects of depot-medroxyprogesterone acetate on immune parameters from several upper reproductive tract compartments relevant to HIV-1 susceptibility in repetitive samples from 15 depot-medroxyprogesterone acetate users and 27 women not on hormonal contraceptives. Compared with samples from unexposed women in the mid-luteal phase, depot-medroxyprogesterone acetate use was associated with: increased endocervical concentrations of MCP1 and IFNalpha2; decreased endocervical concentrations of IL1beta and IL6; increased proportions of endometrial CD4+ and CD8+ cells expressing the activation marker HLADR; increased density of endometrial macrophages; and decreased density of endometrial regulatory T cells...
January 4, 2017: Mucosal Immunology
https://www.readbyqxmd.com/read/28051083/the-loss-of-ccr6-and-cd161-cd4-t-cell-homeostasis-contributes-to-disease-progression-in-siv-infected-rhesus-macaques
#19
C S McGary, X Alvarez, S Harrington, B Cervasi, E S Ryan, R I Iriele, S Paganini, J L Harper, K Easley, G Silvestri, A A Ansari, M Lichterfeld, L Micci, M Paiardini
Although previous studies have shown that CD4(+) T cells expressing CCR6 and CD161 are depleted from blood during HIV infection, the mechanisms underlying their loss remain unclear. In this study, we investigated how the homeostasis of CCR6(+) and CD161(+) CD4(+) T cells contributes to SIV disease progression and the mechanisms responsible for their loss from circulation. By comparing SIV infection in rhesus macaques (RMs) and natural host sooty mangabeys (SMs), we found that the loss of CCR6(+) and CD161(+) CD4(+) T cells from circulation is a distinguishing feature of progressive SIV infection in RMs...
January 4, 2017: Mucosal Immunology
https://www.readbyqxmd.com/read/28045025/interferon-epsilon-promotes-hiv-restriction-at-multiple-steps-of-viral-replication
#20
Albert Garcia-Minambres, Sahar G Eid, Niamh E Mangan, Corinna Pade, San S Lim, Antony Y Matthews, Nicole A de Weerd, Paul J Hertzog, Johnson Mak
Interferon epsilon (IFNɛ) is a type I IFN that is expressed constitutively in the female reproductive tract (FRT), and contributes to protection in models of sexually transmitted infections. Using multiple cell systems, including reporter cell lines and activated peripheral blood lymphocytes (PBLs), we show that recombinant IFNɛ impairs HIV infection at stage(s) post HIV entry and up to the translation of viral proteins. Consistent with this, IFNɛ upregulated a number of host cell restriction factors that block HIV at these stages of the replication cycle...
January 3, 2017: Immunology and Cell Biology
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