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https://www.readbyqxmd.com/read/28213803/first-experiences-with-neuropsychological-effects-of-oxytocin-administration-in-childhood-onset-craniopharyngioma
#1
Anika Hoffmann, Jale Özyurt, Kristin Lohle, Julia Reichel, Christiane M Thiel, Hermann L Müller
PURPOSE: The hypothalamic hormone oxytocin plays a major role in regulation of behavior and body composition. Quality of survival is frequently impaired in childhood craniopharyngioma patients due to sequelae such as behavioral deficits and severe obesity caused by tumor or treatment-related hypothalamic lesions. METHODS: In our pilot cross-sectional study, we analyzed emotion recognition abilities and oxytocin concentrations in saliva and urine before and after single nasal administration of 24 IU oxytocin in 10 craniopharyngioma patients...
February 17, 2017: Endocrine
https://www.readbyqxmd.com/read/28211614/opportunities-for-improving-triple-negative-breast-cancer-outcomes-results-of-a-population-based-study
#2
Elisabetta Rapiti, Kim Pinaud, Pierre O Chappuis, Valeria Viassolo, Aurélie Ayme, Isabelle Neyroud-Caspar, Massimo Usel, Christine Bouchardy
Triple-negative breast cancer (TNBC) is associated with a poor prognosis. Surgery, radiotherapy, chemotherapy, and referral for genetic counseling are the standard of care. We assessed TNBC prevalence, management, and outcome using data from the population-based Geneva cancer registry. 2591 women had a first invasive stage I-III breast cancer diagnosed between 2003 and 2011. We compared TNBC to other breast cancers (OBC) by χ(2) -test and logistic regression. Kaplan-Meier survival curves, up to 31-12-2014, were compared using log-rank test...
February 17, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28208327/issues-associated-with-galilean-invariance-on-a-moving-solid-boundary-in-the-lattice-boltzmann-method
#3
Cheng Peng, Nicholas Geneva, Zhaoli Guo, Lian-Ping Wang
In lattice Boltzmann simulations involving moving solid boundaries, the momentum exchange between the solid and fluid phases was recently found to be not fully consistent with the principle of local Galilean invariance (GI) when the bounce-back schemes (BBS) and the momentum exchange method (MEM) are used. In the past, this inconsistency was resolved by introducing modified MEM schemes so that the overall moving-boundary algorithm could be more consistent with GI. However, in this paper we argue that the true origin of this violation of Galilean invariance (VGI) in the presence of a moving solid-fluid interface is due to the BBS itself, as the VGI error not only exists in the hydrodynamic force acting on the solid phase, but also in the boundary force exerted on the fluid phase, according to Newton's Third Law...
January 2017: Physical Review. E
https://www.readbyqxmd.com/read/28203070/determining-prognosis-in-acute-exacerbation-of-copd
#4
Yves Flattet, Nicolas Garin, Jacques Serratrice, Arnaud Perrier, Jérome Stirnemann, Sebastian Carballo
BACKGROUND: Acute exacerbations are the leading causes of hospitalization and mortality in patients with COPD. Prognostic tools for patients with chronic COPD exist, but there are scarce data regarding acute exacerbations. We aimed to identify the prognostic factors of death and readmission after exacerbation of COPD. METHODS: This was a retrospective study conducted in the Department of Internal Medicine of Geneva University Hospitals. All patients admitted to the hospital with a diagnosis of exacerbation of COPD between 2008 and 2011 were included...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28196486/integrated-care-at-home-reduces-unnecessary-hospitalizations-of-community-dwelling-frail-older-adults-a-prospective-controlled-trial
#5
Laura Di Pollina, Idris Guessous, Véronique Petoud, Christophe Combescure, Bertrand Buchs, Philippe Schaller, Michel Kossovsky, Jean-Michel Gaspoz
BACKGROUND: Care of frail and dependent older adults with multiple chronic conditions is a major challenge for health care systems. The study objective was to test the efficacy of providing integrated care at home to reduce unnecessary hospitalizations, emergency room visits, institutionalization, and mortality in community dwelling frail and dependent older adults. METHODS: A prospective controlled trial was conducted, in real-life clinical practice settings, in a suburban region in Geneva, Switzerland, served by two home visiting nursing service centers...
February 14, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28188641/the-influence-of-plant-protection-by-effective-microorganisms-on-the-content-of-bioactive-phytochemicals-in-apples
#6
Barbara Kusznierewicz, Anna Lewandowska, Dorota Martysiak-Żurowska, Agnieszka Bartoszek
BACKGROUND: The phytochemicals of two apple cultivars (Yellow Transparent and Early Geneva) protected in two ways: conventionally with chemical pesticides or by effective organisms (EM), were compared. Two types of components were determined: lipids synthesized constitutively and generated via inducible pathways polyphenols along with antioxidant activity and profiles. RESULTS: The antioxidant activities assessed with ABTS, DPPH and Folin-Ciocalteu reagents were about twice higher in the case of microbiologically protected apples...
February 11, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28165235/structural-evolution-and-atom-clustering-in-%C3%AE-sialon-%C3%AE-si6-zalzozn8-z
#7
Clayton Cozzan, Kent J Griffith, Geneva Laurita, Jerry G Hu, Clare P Grey, Ram Seshadri
SiAlON ceramics, solid solutions based on the Si3N4 structure, are important, lightweight structural materials with intrinsically high strength, high hardness, and high thermal and chemical stability. Described by the chemical formula β-Si6-zAlzOzN8-z, from a compositional viewpoint, these materials can be regarded as solid solutions between Si3N4 and Al3O3N. A key aspect of the structural evolution with increasing Al and O (z in the formula) is to understand how these elements are distributed on the β-Si3N4 framework...
February 6, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28164125/a-novel-nonpedicular-screw-based-fixation-in-lumbar-spondylolisthesis
#8
Ming-Hong Chen, Jen-Yuh Chen
Objective. The authors present the clinical results obtained in patients who underwent interspinous fusion device (IFD) implantation following posterior lumbar interbody fusion (PLIF). The purpose of this study is investigating the feasibility of IFD with PLIF in the treatment of lumbar spondylolisthesis. Methods. Between September 2013 and November 2014, 39 patients underwent PLIF and subsequent IFD (Romeo®2 PAD, Spineart, Geneva, Switzerland) implantation. Medical records of these patients were retrospectively reviewed to collect relevant data such as blood loss, operative time, and length of hospital stay...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28161601/messages-from-the-first-international-conference-on-clinical-metagenomics-iccmg
#9
Etienne Ruppé, Gilbert Greub, Jacques Schrenzel
Metagenomics is recently entering in the clinical microbiology and an increasing number of diagnostic laboratories are now proposing the sequencing & annotation of bacterial genomes and/or the analysis of clinical samples by direct or PCR-based metagenomics with short time to results. In this context, the first International Conference on Clinical Metagenomics (ICCMg) was held in Geneva in October 2016 and several key aspects have been discussed including: i) the need for improved resolution, ii) the importance of interpretation given the common occurrence of sequence contaminants, iii) the need for improved bioinformatic pipelines, iv) the bottleneck of DNA extraction, v) the importance of gold standards, vi) the need to further reduce time to results, vii) how to improve data sharing, viii) the applications of bacterial genomics and clinical metagenomics in better adapting therapeutics and ix) the impact of metagenomics and new sequencing technologies in discovering new microbes...
February 1, 2017: Microbes and Infection
https://www.readbyqxmd.com/read/28150851/risk-assessment-models-for-venous-thromboembolism-in-acutely-ill-medical-patients-a-systematic-review
#10
Anna K Stuck, David Spirk, Jil Schaudt, Nils Kucher
Although the use of thromboprophylaxis is recommended for acutely ill medical patients at increased risk of venous thromboembolism (VTE), it remains unclear which risk assessment model (RAM) should be routinely used to identify at-risk patients requiring thromboprophylaxis. We therefore aimed to describe existing RAMs, and to compare these tools in terms of validity and applicability for clinical decision-making. We performed a comprehensive systematic search in MEDLINE from the date of initiation until May 2016 for studies in acutely ill medical patients investigating validity of RAMs for VTE...
February 2, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28147583/distraction-distance-and-perceived-disturbance-by-noise-an-analysis-of-21-open-plan-offices
#11
Annu Haapakangas, Valtteri Hongisto, Mervi Eerola, Tuomas Kuusisto
Previous research suggests that, in open-plan offices, noise complaints may be related to the high intelligibility of speech. Distraction distance, which is based on the Speech Transmission Index, can be used to objectively describe the acoustic quality of open-plan offices. However, the relation between distraction distance and perceived noise disturbance has not been established in field studies. The aim of this study was to synthesize evidence from separate studies covering 21 workplaces (N = 883 respondents) and a wide range of room acoustic conditions...
January 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28142008/mandibular-sagittal-split-osteotomy-for-removal-of-impacted-mandibular-teeth-indications-surgical-pitfalls-and-final-outcome
#12
Zulma Catherine, Paolo Scolozzi
PURPOSE: The purpose of this study was to determine the indications for mandibular sagittal split osteotomy (MSSO) for the removal of impacted mandibular teeth and to evaluate the surgical pitfalls and final outcomes. PATIENTS AND METHODS: In this retrospective case-series study, radiologic and clinical data of all patients who underwent MSSO for the removal of impacted mandibular teeth between 2008 and 2015 at the University Hospitals of Geneva were reviewed. The primary outcome variables were 1) the indication for the removal of impacted mandibular teeth by MSSO, 2) complications, and 3) surgical pitfalls...
January 4, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28131587/reducing-gut-effects-from-cryptosporidium-parvum-infection-in-dairy-calves-through-prophylactic-glucagon-like-peptide-2-therapy-or-feeding-of-an-artificial-sweetener
#13
E E Connor, E H Wall, D M Bravo, C M Evock-Clover, T H Elsasser, R L Baldwin, M Santín, B T Vinyard, S Kahl, M P Walker
Glucagon-like peptide 2 (GLP-2) therapy was shown previously to reduce inflammation-related gut damage from coccidiosis in dairy calves, and feeding of artificial sweetener stimulates GLP-2 secretion from intestinal L cells. The purpose of this study was to determine whether GLP-2 treatment or artificial sweetener feeding beginning 1 wk before an experimental inoculation with the coccidian parasite Cryptosporidium parvum can reduce infection-related intestinal damage in Holstein bull calves. Newborn calves were assigned to 1 of 4 treatment groups of 6 calves each, including noninfected control calves injected s...
January 25, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28118267/determinants-of-suicidality-and-of-treatment-modalities-in-a-community-psychiatry-sample-of-asylum-seekers
#14
Natacha Premand, Rachel Baeriswyl-Cottin, Marianne Gex-Fabry, Nikol Hiller, David Framorando, Ariel Eytan, Panteleimon Giannakopoulos, Javier Bartolomei
A high prevalence of mental illness has been reported in asylum seekers. The present cross-sectional study examined suicidal thoughts, treatment modalities (outpatient crisis intervention, inpatient care), and their determinants in asylum seekers (n = 119) and permanent residents (n = 120) attending the same outpatient clinic in Geneva, Switzerland. The most frequent diagnoses were depressive disorders (64.7%) and posttraumatic stress disorder (34.5%) in asylum seekers and psychotic (55.0%) and depressive disorders (33...
January 23, 2017: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/28116533/negative-d-dimer-testing-excludes-pulmonary-embolism-in-non-high-risk-patients-in-the-emergency-department
#15
John B Harringa, Rebecca L Bracken, Scott K Nagle, Mark L Schiebler, Michael S Pulia, James E Svenson, Michael D Repplinger
PURPOSE: The purpose of this study was to assess the ability of d-dimer testing to obviate the need for cross-sectional imaging for patients at "non-high risk" for pulmonary embolism (PE). METHODS: This is a retrospective study of emergency department patients at an academic medical center who underwent cross-sectional imaging (MRA or CTA) to evaluate for PE from 2008 to 2013. The primary outcome was the NPV of d-dimer testing when used in conjunction with clinical decision instruments (CDIs = Wells', Revised Geneva, and Simplified Revised Geneva Scores)...
January 24, 2017: Emergency Radiology
https://www.readbyqxmd.com/read/28109266/team-based-care-for-improving-hypertension-management-among-outpatients-tbc-hta-study-protocol-for-a-pragmatic-randomized-controlled-trial
#16
Valérie Santschi, Grégoire Wuerzner, Arnaud Chiolero, Bernard Burnand, Philippe Schaller, Lyne Cloutier, Gilles Paradis, Michel Burnier
BACKGROUND: Blood pressure (BP) is poorly controlled among a large proportion of hypertensive outpatients. Innovative models of care are therefore needed to improve BP control. The Team-Based Care for improving Hypertension management (TBC-HTA) study aims to evaluate the effect of a team-based care (TBC) interprofessional intervention, involving nurses, community pharmacists and physicians, on BP control of hypertensive outpatients compared to usual care in routine clinical practice. METHODS/DESIGN: The TBC-HTA study is a pragmatic randomized controlled study with a 6-month follow-up which tests a TBC interprofessionnal intervention conducted among uncontrolled treated hypertensive outpatients in two ambulatory clinics and among seven nearby community pharmacies in Lausanne and Geneva, Switzerland...
January 21, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28098707/descriptive-epidemiology-of-acetabular-dysplasia-the-academic-network-of-conservational-hip-outcomes-research-anchor-periacetabular-osteotomy
#17
Wudbhav N Sankar, Stephen T Duncan, Geneva R Baca, Paul E Beaulé, Michael B Millis, Young-Jo Kim, Christopher L Peters, David A Podeszwa, Perry L Schoenecker, Rafael J Sierra, Ernest L Sink, Daniel J Sucato, Robert T Trousdale, Ira Zaltz, John C Clohisy
BACKGROUND: Periacetabular osteotomy (PAO) is an established treatment for symptomatic acetabular dysplasia, which is a well-recognized cause of hip pain, functional limitations, and secondary osteoarthritis. The purpose of this study was to describe the demographics of patients undergoing PAO, the baseline patient-reported outcome measures for this population, and the types of adjunctive procedures performed at the time of PAO surgery. METHODS: Demographics, disease characteristics, and patient-reported functional measures were prospectively collected from all patients who underwent PAO performed by 12 surgeons from 2008 to 2013...
February 2017: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/28070340/civil-society-engagement-in-multi-stakeholder-dialogue-a-qualitative-study-exploring-the-opinions-and-perceptions-of-meta-members
#18
Gemma L Buckland-Merrett, Catherine Kilkenny, Tim Reed
BACKGROUND: The Medicines Transparency Alliance (MeTA) is an initiative that brings together all stakeholders in the medicines market to create a multi-stakeholder dialogue and improve access, availability and affordability of medicines. Key to this multi-stakeholder dialogue is the participation of Civil Society Organisations. A recent MeTA annual review, identified uneven engagement of civil society organisations in the multi-stakeholder process. This study was designed to explore the engagement of Civil Society Organisations in the MeTA multi-stakeholder process and the factors influencing their participation...
2017: Journal of Pharmaceutical Policy and Practice
https://www.readbyqxmd.com/read/28068286/pathobiochemical-mechanisms-relating-iron-homeostasis-to-parameters-of-inflammatory-activity-and-autoimmune-disorders-in-rheumatoid-arthritis
#19
Katya I Stefanova, Ginka T Delcheva, Ana I Maneva, Anastas Z Batalov, Mariela G Geneva-Popova, Rositza V Karalilova, Kiril K Simitchiev
AIM: To find the correlations between the parameters of iron homeostasis, inflammatory activity and autoimmune disorders in rheumatoid arthritis (RA). MATERIALS AND METHODS: The present study included 114 patients with RA and 42 healthy controls. We determined the parameters of iron homeostasis: serum iron, total iron binding capacity (TIBC), ferritin and soluble transferrin receptor (sTfR), the parameters of inflammatory activity: C-reactive protein (CRP), interleukin-6 (IL-6) and prohepcidin, and the parameters of autoimmune disorders: rheumatoid factor (RF), anti-cyclic citrullinated peptide (antiCCP) antibodies, and DAS 28...
December 1, 2016: Folia Medica
https://www.readbyqxmd.com/read/28063507/prevalence-of-low-muscle-mass-according-to-body-mass-index-in-older-adults
#20
Christophe E Graf, Claude Pichard, François R Herrmann, Cornel C Sieber, Dina Zekry, Laurence Genton
OBJECTIVE: Low muscle mass has been associated with increased morbi-mortality and should be identified for optimizing preventive and therapeutic strategies. This study evaluates the prevalence of bioelectrical impedance analysis (BIA)-derived low muscle mass in older persons using definitions found through a systematic literature search and determines the link between body mass index (BMI) and low muscle mass. METHODS: We performed a systematic search of trials involving ≥100 persons that derived low muscle mass from BIA and reported cut-offs for low muscle mass normalized for body height or weight...
February 2017: Nutrition
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