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https://www.readbyqxmd.com/read/28098707/descriptive-epidemiology-of-acetabular-dysplasia-the-academic-network-of-conservational-hip-outcomes-research-anchor-periacetabular-osteotomy
#1
Wudbhav N Sankar, Stephen T Duncan, Geneva R Baca, Paul E Beaulé, Michael B Millis, Young-Jo Kim, Christopher L Peters, David A Podeszwa, Perry L Schoenecker, Rafael J Sierra, Ernest L Sink, Daniel J Sucato, Robert T Trousdale, Ira Zaltz, John C Clohisy
BACKGROUND: Periacetabular osteotomy (PAO) is an established treatment for symptomatic acetabular dysplasia, which is a well-recognized cause of hip pain, functional limitations, and secondary osteoarthritis. The purpose of this study was to describe the demographics of patients undergoing PAO, the baseline patient-reported outcome measures for this population, and the types of adjunctive procedures performed at the time of PAO surgery. METHODS: Demographics, disease characteristics, and patient-reported functional measures were prospectively collected from all patients who underwent PAO performed by 12 surgeons from 2008 to 2013...
February 2017: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/28070340/civil-society-engagement-in-multi-stakeholder-dialogue-a-qualitative-study-exploring-the-opinions-and-perceptions-of-meta-members
#2
Gemma L Buckland-Merrett, Catherine Kilkenny, Tim Reed
BACKGROUND: The Medicines Transparency Alliance (MeTA) is an initiative that brings together all stakeholders in the medicines market to create a multi-stakeholder dialogue and improve access, availability and affordability of medicines. Key to this multi-stakeholder dialogue is the participation of Civil Society Organisations. A recent MeTA annual review, identified uneven engagement of civil society organisations in the multi-stakeholder process. This study was designed to explore the engagement of Civil Society Organisations in the MeTA multi-stakeholder process and the factors influencing their participation...
2017: Journal of Pharmaceutical Policy and Practice
https://www.readbyqxmd.com/read/28068286/pathobiochemical-mechanisms-relating-iron-homeostasis-to-parameters-of-inflammatory-activity-and-autoimmune-disorders-in-rheumatoid-arthritis
#3
Katya I Stefanova, Ginka T Delcheva, Ana I Maneva, Anastas Z Batalov, Mariela G Geneva-Popova, Rositza V Karalilova, Kiril K Simitchiev
AIM: To find the correlations between the parameters of iron homeostasis, inflammatory activity and autoimmune disorders in rheumatoid arthritis (RA). MATERIALS AND METHODS: The present study included 114 patients with RA and 42 healthy controls. We determined the parameters of iron homeostasis: serum iron, total iron binding capacity (TIBC), ferritin and soluble transferrin receptor (sTfR), the parameters of inflammatory activity: C-reactive protein (CRP), interleukin-6 (IL-6) and prohepcidin, and the parameters of autoimmune disorders: rheumatoid factor (RF), anti-cyclic citrullinated peptide (antiCCP) antibodies, and DAS 28...
December 1, 2016: Folia Medica
https://www.readbyqxmd.com/read/28063507/prevalence-of-low-muscle-mass-according-to-body-mass-index-in-older-adults
#4
Christophe E Graf, Claude Pichard, François R Herrmann, Cornel C Sieber, Dina Zekry, Laurence Genton
OBJECTIVE: Low muscle mass has been associated with increased morbi-mortality and should be identified for optimizing preventive and therapeutic strategies. This study evaluates the prevalence of bioelectrical impedance analysis (BIA)-derived low muscle mass in older persons using definitions found through a systematic literature search and determines the link between body mass index (BMI) and low muscle mass. METHODS: We performed a systematic search of trials involving ≥100 persons that derived low muscle mass from BIA and reported cut-offs for low muscle mass normalized for body height or weight...
February 2017: Nutrition
https://www.readbyqxmd.com/read/28060231/patient-reported-outcomes-of-periacetabular-osteotomy-from-the-prospective-anchor-cohort-study
#5
John C Clohisy, Jeffrey Ackerman, Geneva Baca, Jack Baty, Paul E Beaulé, Young-Jo Kim, Michael B Millis, David A Podeszwa, Perry L Schoenecker, Rafael J Sierra, Ernest L Sink, Daniel J Sucato, Robert T Trousdale, Ira Zaltz
BACKGROUND: Current literature describing the periacetabular osteotomy (PAO) is mostly limited to retrospective case series. Larger, prospective cohort studies are needed to provide better clinical evidence regarding this procedure. The goals of the current study were to (1) report minimum 2-year patient-reported outcomes (pain, hip function, activity, overall health, and quality of life), (2) investigate preoperative clinical and disease characteristics as predictors of clinical outcomes, and (3) report the rate of early failures and reoperations in patients undergoing contemporary PAO surgery...
January 4, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28040024/optimized-single-number-quantity-for-rating-the-airborne-sound-insulation-of-constructions-living-sounds
#6
Petra Virjonen, Valtteri Hongisto, David Oliva
ISO 717-1 [(1996). International Organization for Standardization, Geneva, Switzerland] and ASTM 413 [(2010). American Society for Testing and Materials International] define various single-number quantities (SNQs) that are commonly used to rate objectively airborne sound insulation of constructions. Recent psychoacoustic evidence suggests that none of them is appropriate for a wide range of living sound stimuli. The purpose of the study was to develop an alternative compromising SNQ for the frequency range 50-5000 Hz that explains well the annoyance caused by various airborne living sounds transmitted from the neighboring dwelling...
December 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28027519/estimation-of-net-survival-for-cancer-patients-relative-survival-setting-more-robust-to-some-assumption-violations-than-cause-specific-setting-a-sensitivity-analysis-on-empirical-data
#7
Robin Schaffar, Bernard Rachet, Aurélien Belot, Laura M Woods
Net survival is the survival that would be observed if the only possible underlying cause of death was the disease under study. It can be estimated with either cause-specific or relative survival data settings, if the informative censoring is properly considered. However, net survival estimators are prone to specific biases related to the data setting itself. We examined which data setting was the most robust against violation of key assumptions (erroneous cause of death and inappropriate life tables). We identified 4285 women in the Geneva Cancer Registry, diagnosed with breast, colorectal, lung cancer and melanoma between 1981 and 1991 and estimated net survival up to 20 years using cause-specific and relative survival settings...
December 24, 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/28024770/indirect-vs-direct-bonding-of-mandibular-fixed-retainers-in-orthodontic-patients-comparison-of-retainer-failures-and-posttreatment-stability-a-2-year-follow-up-of-a-single-center-randomized-controlled-trial
#8
Fabienne Egli, Efstathia Bovali, Stavros Kiliaridis, Marie A Cornelis
INTRODUCTION: The objectives of this 2-arm parallel trial were to compare the numbers of failures of mandibular fixed retainers bonded with indirect and direct methods and to investigate the posttreatment changes 2 years after placement. METHODS: Sixty-four consecutive patients from the postgraduate orthodontic clinic of the University of Geneva in Switzerland were randomly allocated to either an indirect or a traditional direct bonding procedure of a mandibular fixed retainer at the end of their orthodontic treatment (T0)...
January 2017: American Journal of Orthodontics and Dentofacial Orthopedics
https://www.readbyqxmd.com/read/28019652/clinical-validation-of-reduced-alcohol-consumption-after-treatment-for-alcohol-dependence-using-the-world-health-organization-risk-drinking-levels
#9
Katie Witkiewitz, Kevin A Hallgren, Henry R Kranzler, Karl F Mann, Deborah S Hasin, Daniel E Falk, Raye Z Litten, Stephanie S O'Malley, Raymond F Anton
BACKGROUND: Alcohol use disorder (AUD) is a highly prevalent public health problem associated with considerable individual and societal costs. Abstinence from alcohol is the most widely accepted target of treatment for AUD, but it severely limits treatment options and could deter individuals who prefer to reduce their drinking from seeking treatment. Clinical validation of reduced alcohol consumption as the primary outcome of alcohol clinical trials is critical for expanding treatment options...
January 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28018904/3d-volumetric-modeling-and-microvascular-reconstruction-of-irradiated-lumbosacral-defects-after-oncologic-resection
#10
Emilio Garcia-Tutor, Marco Romeo, Michael P Chae, David J Hunter-Smith, Warren Matthew Rozen
BACKGROUND: Locoregional flaps are sufficient in most sacral reconstructions. However, large sacral defects due to malignancy necessitate a different reconstructive approach, with local flaps compromised by radiation and regional flaps inadequate for broad surface areas or substantial volume obliteration. In this report, we present our experience using free muscle transfer for volumetric reconstruction, in such cases, and demonstrate three-dimensional (3D) haptic models of the sacral defect to aid preoperative planning...
2016: Frontiers in Surgery
https://www.readbyqxmd.com/read/28007362/best-clinical-practice-controversies-in-outpatient-management-of-acute-pulmonary-embolism
#11
Brit Long, Alex Koyfman
BACKGROUND: Pulmonary embolism (PE) is a common condition managed in the emergency department (ED), with a wide range of morbidity and mortality. Patients are classically admitted for treatment and monitoring of anticoagulation. OBJECTIVE: We sought to evaluate the controversy concerning outpatient therapy for patients with acute PE and investigate the feasibility, safety, and efficacy of outpatient management. DISCUSSION: Patients with venous thromboembolism have historically been admitted for treatment and monitoring for concern of worsening disease or side effects of anticoagulation (bleeding)...
December 19, 2016: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28005090/-guidelines-for-the-use-of-the-international-classification-of-radiographs-of-pneumoconioses-of-the-international-labour-office-ilo-substantial-changes-in-the-currrent-edition
#12
Maja Muszyńska-Graca, Beata Dąbkowska, Piotr Z Brewczyński
The International Classification of Radiographs of Pneumoconioses is the scheme worked out by the International Labour Office in Geneva (ILO), to register radiographic chest abnormalities in a well-ordered, reproducible and comparable way. It is used for diagnosing abnormalities caused by dust exposure. Guidelines for the use of the ILO International Classification of Radiographs of Pneumoconioses contain detailed information and recommendations on how to use the classification, as well as how the chest X-ray examination should be performed and recorded...
December 22, 2016: Medycyna Pracy
https://www.readbyqxmd.com/read/27995531/effect-on-cognition-of-estroprogestins-combined-with-interferon-beta-in-multiple-sclerosis-analysis-of-secondary-outcomes-from-a-randomised-controlled-trial
#13
Laura De Giglio, Fabiana Marinelli, Valeria T Barletta, Veronica A Pagano, Floriana De Angelis, Fulvia Fanelli, Nikolaos Petsas, Patrizia Pantano, Valentina Tomassini, Carlo Pozzilli
INTRODUCTION: Cognitive impairment is a disabling symptom in multiple sclerosis (MS). While its management remains challenging, beneficial effects on cognition of interferon beta (IFN-β) have been reported and a positive effect from estroprogestins has been hypothesised, suggesting that the combination of the two medications in women with MS could offer a promising treatment strategy. OBJECTIVES: We investigated whether a combination of estroprogestins and IFN-β can improve cognition in women with MS...
December 19, 2016: CNS Drugs
https://www.readbyqxmd.com/read/27988553/revision-of-the-genus-i-pselaphomorphus-i-motschulsky-1855-staphylinidae-pselaphinae-jubini-corrections
#14
Laura M Vásquez-Vélez
In my revision of the genus Pselaphomorphus Motschulsky, 1855 (Vásquez-Vélez 2016) the depository of the holotype of P. cayennensis Vásquez-Vélez, 2016 was not listed. As a result, the requirements of Article 16.4.2 of the International Code of Zoological Nomenclature (International Commission on Zoological Nomenclature 1999) have not been met, making the name unavailable. This note aims at correcting the earlier mistake: the holotype of P. cayennensis is deposited at the Museum of natural history (Muséum d'histoire naturelle), Geneva, Switzerland...
December 12, 2016: Zootaxa
https://www.readbyqxmd.com/read/27974638/untangling-ciliary-access-and-enrichment-of-two-rhodopsin-like-receptors-using-quantitative-fluorescence-microscopy-reveals-cell-specific-sorting-pathways
#15
Ivayla I Geneva, Han Yen Tan, Peter D Calvert
Resolution limitations of optical systems are major obstacles for determining if proteins are enriched within cell compartments. Here we employ an approach to determine the degree of membrane protein ciliary enrichment that quantitatively accounts for the differences in sampling of the ciliary and apical membranes inherent to confocal microscopes. Theory shows that cilia will appear more than threefold brighter than the surrounding apical membrane when the densities of fluorescently labeled proteins are the same, thus providing a benchmark for ciliary enrichment...
December 14, 2016: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/27941007/age-adjusted-d-dimer-excludes-pulmonary-embolism-and-reduces-unnecessary-radiation-exposure-in-older-adults-retrospective-study
#16
Jennifer Nobes, Claudia-Martina Messow, Mohammed Khan, Petr Hrobar, Chris Isles
BACKGROUND: Patients in whom a diagnosis of pulmonary embolism (PE) is suspected and whose D-dimers are elevated frequently require CT pulmonary angiogram (CTPA) for diagnosis. Because D-dimer rises with age, an age-adjusted D-dimer threshold may prevent unnecessary radiation exposure from CTPA in older patients. OBJECTIVE: To determine the efficacy and safety of implementing an age-adjusted D-dimer threshold to exclude PE. DESIGN, SETTINGS AND PATIENTS: Retrospective comparison of conventional and age-adjusted D-dimer thresholds in 1000 consecutive patients who had both D-dimer and CTPA...
December 9, 2016: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/27936213/radiologic-histopathologic-correlation-of-cerebral-microbleeds-using-pre-mortem-and-post-mortem-mri
#17
Sven Haller, Marie-Louise Montandon, François Lazeyras, Max Scheffler, Stephan Meckel, Francois R Herrmann, Panteleimon Giannakopoulos, Enikö Kövari
INTRODUCTION: Cerebral microbleeds (CMB), also known as cerebral microhemorrhages, are small areas of susceptibility on brain magnetic resonance imaging (MRI), that are increasingly detected due to the higher availability of high-field MRI systems and dedicated pulse sequences. The prevalence of CMBs increases in cases with cognitive decline. The current investigation assessed the poorly investigated radiologic-histopathologic correlation of CMBs on MRI. METHODS: The local ethical committee approved the current investigation...
2016: PloS One
https://www.readbyqxmd.com/read/27931513/immunogenicity-of-anti-hla-antibodies-in-pancreas-and-islet-transplantation
#18
Benjamin Chaigne, Kirsten Geneugelijk, Benot Bdat, Mohamed Alibashe Ahmed, Gideon Hnger, Sophie de Seigneux, Sandrine Demuylder-Mischler, Thierry Berney, Eric Spierings, Sylvie Ferrari-Lacraz, Jean Villard
The aim of the current study was to characterize the anti-HLA antibodies before and after pancreatic islet or pancreas transplantation. We assessed the risk of anti-donor-specific antibody (DSA) sensitization in a single-center, retrospective clinical study at Geneva University Hospital. Data regarding clinical characteristics, graft outcome, HLA mismatch, donor HLA immunogenicity, and anti-HLA antibody characteristics were collected. Between January 2008 and July 2014, 18 patients received islet transplants, and 26 patients received a pancreas transplant...
November 2016: Cell Transplantation
https://www.readbyqxmd.com/read/27927884/esthetic-and-clinical-performance-of-implant-supported-all-ceramic-crowns-made-with-prefabricated-or-cad-cam-zirconia-abutments-a-randomized-multicenter-clinical-trial
#19
J G Wittneben, J Gavric, U C Belser, M M Bornstein, T Joda, V Chappuis, I Sailer, U Brägger
Patients' esthetic expectations are increasing, and the options of the prosthetic pathways are currently evolving. The objective of this randomized multicenter clinical trial was to assess and compare the esthetic outcome and clinical performance of anterior maxillary all-ceramic implant crowns (ICs) based either on prefabricated zirconia abutments veneered with pressed ceramics or on CAD/CAM zirconia abutments veneered with hand buildup technique. The null hypothesis was that there is no statistically significant difference between the 2 groups...
December 7, 2016: Journal of Dental Research
https://www.readbyqxmd.com/read/27927220/e-learning-for-research-capacity-strengthening-in-sexual-and-reproductive-health-the-experience-of-the-geneva-foundation-for-medical-education-and-research-and-the-department-of-reproductive-health-and-research-world-health-organization
#20
Karim Abawi, Venkatraman Chandra-Mouli, Igor Toskin, Mario Philip Festin, Lynn Gertiser, Raqibat Idris, Hanan Hamamy, Moazzam Ali, Ameyo Masakhwe Bonventure, Marleen Temmerman, Aldo Campana
: Technological advancement has resulted in the increasing use of e-learning and online education, initially in high-income countries and increasingly in low- and middle-income countries. BACKGROUND: In 2010, the Geneva Foundation for Medical Education and Research, in collaboration with the World Health Organization and partner institutions, developed an online postgraduate course "From Research to Practice: Training Course in Sexual and Reproductive Health Research"...
December 7, 2016: Human Resources for Health
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