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https://www.readbyqxmd.com/read/27898813/genome-to-phenome-mapping-in-apple-using-historical-data
#1
Zoë Migicovsky, Kyle M Gardner, Daniel Money, Jason Sawler, Joshua S Bloom, Peter Moffett, C Thomas Chao, Heidi Schwaninger, Gennaro Fazio, Gan-Yuan Zhong, Sean Myles
Apple ( X Borkh.) is one of the world's most valuable fruit crops. Its large size and long juvenile phase make it a particularly promising candidate for marker-assisted selection (MAS). However, advances in MAS in apple have been limited by a lack of phenotype and genotype data from sufficiently large samples. To establish genotype-phenotype relationships and advance MAS in apple, we extracted over 24,000 phenotype scores from the USDA-Germplasm Resources Information Network (GRIN) database and linked them with over 8000 single nucleotide polymorphisms (SNPs) from 689 apple accessions from the USDA apple germplasm collection clonally preserved in Geneva, NY...
July 2016: Plant Genome
https://www.readbyqxmd.com/read/27889116/total-phallic-reconstruction-using-radial-forearm-free-flap-after-iatrogenic-penile-amputation
#2
J C Angulo, I Arance, C Gómez-Llorens, C Esquinas, C Gómez-Martín, J L Fernández-Cañamaque
INTRODUCTION: The iatrogenic loss of the penis is a rare situation. We present a challenging case of deferred total penile reconstruction in a genetic male. MATERIAL AND METHODS: A 57-year-old man with the loss of the penis due to a penile abscess and necrosis secondary to penile curvature surgery. The reconstruction was performed over several operations using a radial forearm free flap (RFFF) and placement of a customised inflatable prosthesis a year later. RESULTS: During the first operation, the penile abscess was drained, the necrotic residues were debrided and placement of hypogastric drainage...
November 23, 2016: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/27862778/reentrant-structural-and-optical-properties-and-large-positive-thermal-expansion-in-perovskite-formamidinium-lead-iodide
#3
Douglas H Fabini, Constantinos C Stoumpos, Geneva Laurita, Andreas Kaltzoglou, Athanassios G Kontos, Polycarpos Falaras, Mercouri G Kanatzidis, Ram Seshadri
The structure of the hybrid perovskite HC(NH2 )2 PbI3 (formamidinium lead iodide) reflects competing interactions associated with molecular motion, hydrogen bonding tendencies, thermally activated soft octahedral rotations, and the propensity for the Pb(2+) lone pair to express its stereochemistry. High-resolution synchrotron X-ray powder diffraction reveals a continuous transition from the cubic α-phase (Pm3‾ m, #221) to a tetragonal β-phase (P4/mbm, #127) at around 285 K, followed by a first-order transition to a tetragonal γ-phase (retaining P4/mbm, #127) at 140 K...
November 10, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27851366/1731-challenges-associated-with-diagnosis-of-catastrophic-antiphospholipid-syndrome
#4
Reddy Singasani, Geneva Tatem, Lenar Yessayan
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27844159/clinical-and-epidemiological-differences-between-implant-associated-and-implant-free-orthopaedic-infections
#5
Céline Cuérel, Sophie Abrassart, Julien Billières, Diego Andrey, Domizio Suva, Victor Dubois-Ferrière, Ilker Uçkay
PURPOSE: Although there have been many publications regarding the risk factors for implant-associated orthopaedic infections, none have investigated how clinical presentations and epidemiology may differ between infections with and without osteosynthetic material. METHODS: We pooled clinical data from several databases of adult patients with orthopaedic infections hospitalized at Geneva University Hospitals from January 2004 to December 2014. RESULTS: Among 2740 episodes of orthopaedic infections, 76% were implant-free osteoarticular or soft tissue infections...
November 14, 2016: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/27834170/feedback-in-formative-osces-comparison-between-direct-observation-and-video-based-formats
#6
Noëlle Junod Perron, Martine Louis-Simonet, Bernard Cerutti, Eva Pfarrwaller, Johanna Sommer, Mathieu Nendaz
INTRODUCTION: Medical students at the Faculty of Medicine, University of Geneva, Switzerland, have the opportunity to practice clinical skills with simulated patients during formative sessions in preparation for clerkships. These sessions are given in two formats: 1) direct observation of an encounter followed by verbal feedback (direct feedback) and 2) subsequent review of the videotaped encounter by both student and supervisor (video-based feedback). The aim of the study was to evaluate whether content and process of feedback differed between both formats...
2016: Medical Education Online
https://www.readbyqxmd.com/read/27825057/how-does-delivery-method-influence-factors-that-contribute-to-women-s-childbirth-experiences
#7
Pierre Carquillat, Michel Boulvain, Marie-Julia Guittier
BACKGROUND: whether delivery method influences factors contributing to women's childbirth experience remains debated. OBJECTIVE: we compared subjective childbirth experience according to different delivery methods. DESIGN: this study used a cross-sectional design. SETTING: the setting comprised two university hospitals: one in Geneva, Switzerland and one in Clermont-Ferrand, France. PARTICIPANTS: a total of 291 primiparous women were recruited from July 2014 to January 2015 during their stay in the maternity wards...
October 8, 2016: Midwifery
https://www.readbyqxmd.com/read/27813343/a-multicenter-study-to-assess-the-reproducibility-of-antiphospholipid-antibody-results-produced-by-an-automated-system
#8
K M Devreese, A Poncet, E Lindhoff-Last, J Musial, P de Moerloose, P Fontana
BACKGROUND: Inter-assay variability is a well-known problem in antiphospholipid antibody testing, due to the lack of standardization. Inter-lab reproducibility for a same assay is similarly important. OBJECTIVES: Testing repeatability and reproducibility of HemosIL(®) AcuStar for anticardiolipin (aCL) and aβ2GPI IgG and IgM. PATIENTS/METHODS: In this observational study, out of 420 samples from the thrombophilia centers of Ghent and Geneva, 100 samples were randomly selected and successively analyzed in three centers: Ghent (C1, in duplicate for repeatability evaluation), Geneva (C2) and Frankfurt (C3)...
November 4, 2016: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/27798042/effectiveness-of-lifestyle-intervention-in-subgroups-of-obese-infertile-women-a-subgroup-analysis-of-a-rct
#9
A M van Oers, H Groen, M A Q Mutsaerts, J M Burggraaff, W K H Kuchenbecker, D A M Perquin, C A M Koks, R van Golde, E M Kaaijk, J M Schierbeek, G J E Oosterhuis, F J Broekmans, N E A Vogel, J A Land, B W J Mol, A Hoek
STUDY QUESTION: Do age, ovulatory status, severity of obesity and body fat distribution affect the effectiveness of lifestyle intervention in obese infertile women? SUMMARY ANSWER: We did not identify a subgroup in which lifestyle intervention increased the healthy live birth rate however it did increase the natural conception rate in anovulatory obese infertile women. WHAT IS KNOWN ALREADY: Obese women are at increased risk of infertility and are less likely to conceive after infertility treatment...
October 19, 2016: Human Reproduction
https://www.readbyqxmd.com/read/27796163/bioimpedance-derived-phase-angle-and-mortality-among-older-people
#10
Laurence Genton, Kristina Norman, Adrian Spoerri, Claude Pichard, Véronique L Karsegard, François R Herrmann, Christophe E Graf
BACKGROUND: Phase angle measured by bioelectrical impedance analysis (BIA) may be a marker of health state. OBJECTIVE: This historical cohort study of prospectively collected BIA measurements aims to investigate the link between phase angle and mortality in older people and evaluate whether a phase angle cutoff can be defined. DESIGN: We included all adults aged ≥65 years who underwent a BIA measurement by the Nutriguard(®) device at the Geneva University Hospitals...
December 2, 2016: Rejuvenation Research
https://www.readbyqxmd.com/read/27760489/geneva-seattle-collaboration-in-support-of-developing-country-vaccine-manufacturing
#11
Michael A Stevenson
Vaccines were once produced almost exclusively by state-supported entities. While they remain essential tools for public health protection, the majority of the world's governments have allowed industry to assume responsibility for this function. This is significant because while the international harmonisation of quality assurance standards have effectively increased vaccine safety, they have also reduced the number of developing country vaccine producers, and Northern multinational pharmaceutical companies have shown little interest in offering the range of low-priced products needed in low and middle-income-country contexts...
October 19, 2016: Global Public Health
https://www.readbyqxmd.com/read/27756711/imipenem-heteroresistance-in-nontypeable-haemophilus-influenzae-is-linked-to-a-combination-of-altered-pbp3-slow-drug-influx-and-direct-efflux-regulation
#12
A Cherkaoui, S M Diene, A Renzoni, S Emonet, G Renzi, P François, J Schrenzel
OBJECTIVES: The aim of the present work was to investigate the potential roles of PBPs, efflux pumps, and slow drug influx for imipenem heteroresistance in nontypeable Haemophilus influenzae (NTHi). METHODS: The 59 NTHi clinical isolates examined in this study were collected at Geneva University Hospitals between 2009 and 2014. Alterations in PBPs were investigated by gene sequencing. To evaluate the affinities of the PBPs to imipenem, steady-state concentration-response experiments were carried out using imipenem in a competition assay with Bocillin-FL...
October 15, 2016: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/27752447/pesticides-in-surface-waters-a-comparison-with-regulatory-acceptable-concentrations-racs-determined-in-the-authorization-process-and-consideration-for-regulation
#13
Katja Knauer
BACKGROUND: Chemical analysis of surface water conducted in European countries indicates that pesticides are often detected in surface waters. This asks regulatory authorities to consider these monitoring data while re-evaluating pesticide approval and setting appropriate risk mitigation measures. During the years 2005-2012, the cantons in Switzerland performed 345,000 pesticide measurements in surface waters. Overall, 203 approved pesticides were examined. For 60 of these substances, regulatory acceptable concentrations (RACs) were published, which were determined from ecotoxicological data in accordance with international test methods within the framework of the authorization procedure...
2016: Environmental Sciences Europe
https://www.readbyqxmd.com/read/27749336/ehealth-for-all-report-from-ni-2016-in-geneva-switzerland
#14
Heather Carter-Templeton, Leslie H Nicoll
No abstract text is available yet for this article.
October 2016: Computers, Informatics, Nursing: CIN
https://www.readbyqxmd.com/read/27744604/antimicrobial-activity-of-ceftaroline-against-methicillin-resistant-staphylococcus-aureus-mrsa-isolates-collected-in-2013-2014-at-the-geneva-university-hospitals
#15
D O Andrey, P François, C Manzano, E J Bonetti, S Harbarth, J Schrenzel, W L Kelley, A Renzoni
Ceftaroline is a broad-spectrum antibiotic with activity against methicillin-resistant Staphylococcus aureus (MRSA) strains. Ceftaroline susceptibility of an MRSA set archived between 1994 and 2003 in the Geneva University Hospitals detected a high percentage (66 %) of ceftaroline resistance in clonotypes ST228 and ST247 and correlated with mutations in PBP2a. The ceftaroline mechanism of action is based on the inhibition of PBP2a; thus, the identification of PBP2a mutations of recently circulating clonotypes in our institution was investigated...
October 15, 2016: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/27740788/24-hour-relativistic-bit-commitment
#16
Ephanielle Verbanis, Anthony Martin, Raphaël Houlmann, Gianluca Boso, Félix Bussières, Hugo Zbinden
Bit commitment is a fundamental cryptographic primitive in which a party wishes to commit a secret bit to another party. Perfect security between mistrustful parties is unfortunately impossible to achieve through the asynchronous exchange of classical and quantum messages. Perfect security can nonetheless be achieved if each party splits into two agents exchanging classical information at times and locations satisfying strict relativistic constraints. A relativistic multiround protocol to achieve this was previously proposed and used to implement a 2-millisecond commitment time...
September 30, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27731337/production-of-valuable-compounds-by-molds-and-yeasts
#17
Arnold L Demain, Evan Martens
We are pleased to dedicate this paper to Dr Julian E Davies. Julian is a giant among microbial biochemists. He began his professional career as an organic chemistry PhD student at Nottingham University, moved on to a postdoctoral fellowship at Columbia University, then became a lecturer at the University of Manchester, followed by a fellowship in microbial biochemistry at Harvard Medical School. In 1965, he studied genetics at the Pasteur Institute, and 2 years later joined the University of Wisconsin in the Department of Biochemistry...
October 12, 2016: Journal of Antibiotics
https://www.readbyqxmd.com/read/27731334/julian-davies-and-the-discovery-of-kanamycin-resistance-transposon-tn5
#18
Douglas E Berg
This paper recounts some of my fond memories of a collaboration between Julian Davies and myself that started in 1974 in Geneva and that led to our serendipitous discovery of the bacterial kanamycin resistance transposon Tn5, and aspects of the lasting positive impact of our interaction and discovery on me and the community. Tn5 was one of the first antibiotic resistance transposons to be found. Its analysis over the ensuing decades provided valuable insights into mechanisms and control of transposition, and led to its use as a much-valued tool in diverse areas of molecular genetics, as also will be discussed here...
October 12, 2016: Journal of Antibiotics
https://www.readbyqxmd.com/read/27729018/is-patient-satisfaction-with-organizational-aspects-of-their-general-practitioner-s-practice-associated-with-patient-and-doctor-gender-an-observational-study
#19
Paul Sebo, François R Herrmann, Dagmar M Haller
BACKGROUND: No study has assessed the association between patients' and doctors' gender and patient satisfaction with organizational aspects of health care in primary care. However, just like satisfaction regarding communication styles or technical skills, satisfaction towards organization of the general practitioner (GP) practice could also depend on doctors' and/or patients' gender. Different expectations between female and male patients regarding the organization of the practice or different ways of organizing care delivery between female and male GPs could act on this satisfaction...
August 27, 2016: BMC Family Practice
https://www.readbyqxmd.com/read/27716256/use-of-email-cell-phone-and-text-message-between-patients-and-primary-care-physicians-cross-sectional-study-in-a-french-speaking-part-of-switzerland
#20
Jonathan Dash, Dagmar M Haller, Johanna Sommer, Noelle Junod Perron
BACKGROUND: Physicians' daily work is increasingly affected by the use of emails, text messages and cell phone calls with their patients. The aim of this study was to describe their use between primary-care physicians and patients in a French-speaking part of Switzerland. METHODS: A cross-sectional mail survey was conducted among all primary-care physicians of Geneva canton (n = 636). The questionnaire focused on the frequency of giving access to, type of use, advantages and disadvantages of email, cell phone calls and text messages communication between physicians and patients...
October 5, 2016: BMC Health Services Research
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