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https://www.readbyqxmd.com/read/29447395/characteristics-and-outcomes-of-coronavirus-infection-in-children-the-role-of-viral-factors-and-an-immunocompromised-state
#1
Chikara Ogimi, Janet A Englund, Miranda C Bradford, Xuan Qin, Michael Boeckh, Alpana Waghmare
Background: Immunocompromised children might be predisposed to serious infections from human coronaviruses (HCoVs), including strains OC43, NL63, HKU1, and 229E; however, the virologic and clinical features of HCoV infection in immunocompromised children have not been compared to those in nonimmunocompromised children. Methods: We retrospectively analyzed a cohort of children who presented to Seattle Children's Hospital and in whom HCoV was detected by a multiplex respiratory polymerase chain reaction assay of a nasal sample between October 2012 and March 2016...
February 13, 2018: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/29439130/limb-and-person-level-risk-factors-for-lower-limb-amputation-in-the-prospective-seattle-diabetic-foot-study
#2
Edward J Boyko, Amber D Seelig, Jessie H Ahroni
OBJECTIVE: Diabetes is the leading cause of nontraumatic lower-limb amputations in the U.S., but no research has prospectively examined associations between limb-specific measurements and amputation risk among patients without foot ulcer. We investigated amputation risk by limb in relation to the same limb- and person-level factors. RESEARCH DESIGN AND METHODS: We conducted a 22-year prospective study among 1,461 male patients with diabetes without foot ulcer (mean age 62...
February 8, 2018: Diabetes Care
https://www.readbyqxmd.com/read/29438954/dietary-intake-and-urinary-metals-among-pregnant-women-in-the-pacific-northwest
#3
Citlalli Osorio-Yáñez, Bizu Gelaye, Daniel A Enquobahrie, Chunfang Qiu, Michelle A Williams
Pregnancy is a period when the mother and her offspring are susceptible to the toxic effects of metals. We investigated associations of intake of frequently consumed foods with urinary metals concentrations among pregnant women in the Pacific Northwest. We measured urinary cadmium (U-Cd), arsenic (U-As) and molybdenum (U-Mo) concentrations from spot urine samples in early pregnancy (15 weeks of gestation, on average) among 558 women from Seattle and Tacoma, Washington. We assessed periconceptional dietary intake using a semi-quantitative food frequency questionnaire (FFQ)...
February 10, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29424731/efficacy-of-cardiac-shock-wave-therapy-in-patients-with-stable-angina-the-design-of-randomized-triple-blind-sham-procedure-controlled-study
#4
Evgeny Shkolnik, Greta Burneikaite, Jelena Celutkiene, Mikhail Scherbak, Gitana Zuoziene, Birute Petrauskiene, Ekaterina Trush, Aleksandras Laucevicius, Yury Vasyuk
OBJECTIVE: Despite revascularization and optimal medical treatment (OMT), patients with angina often have a reduced quality of life due to inadequate relief from symptoms. Recent studies have shown that the application of shock waves may reduce angina symptoms and improve quality of life, exercise capacity, and myocardial perfusion due to the stimulation of angiogenesis. However, there is limited evidence due to small, single-arm, single-center studies of low to moderate quality. The purpose of this study is to evaluate the impact of cardiac shock wave therapy (CSWT) on exercise tolerance and angina symptoms in patients with coronary artery disease and objective evidence of myocardial ischemia who cannot undergo traditional revascularization and experience angina despite OMT in comparison to sham procedure...
February 2018: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/29410080/incremental-yield-of-dysplasia-detection-in-barrett-s-esophagus-using-volumetric-laser-endomicroscopy-with-and-without-laser-marking-compared-with-a-standardized-random-biopsy-protocol
#5
Mohammad Alshelleh, Sumant Inamdar, Matthew McKinley, Molly Stewart, Jeffrey S Novak, Ronald E Greenberg, Keith Sultan, Bethany Devito, Mary Cheung, Maurice A Cerulli, Larry S Miller, Divyesh V Sejpal, Anil K Vegesna, Arvind J Trindade
BACKGROUND AND AIMS: Volumetric laser endomicroscopy (VLE) is a new wide field advanced imaging technology for Barrett's esophagus (BE). No data exist on incremental yield of dysplasia detection. Our aim is to report the incremental yield of dysplasia detection in BE using VLE. METHODS: This is a retrospective study from a prospectively maintained database from 2011-2017 comparing the dysplasia yield of 4 different surveillance strategies in an academic BE tertiary care referral center...
February 2, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29409555/seattle-s-minimum-wage-ordinance-did-not-affect-supermarket-food-prices-by-food-processing-category
#6
Amanda L Spoden, James H Buszkiewicz, Adam Drewnowski, Mark C Long, Jennifer J Otten
OBJECTIVE: To examine the impacts of Seattle's minimum wage ordinance on food prices by food processing category. DESIGN: Supermarket food prices were collected for 106 items using a University of Washington Center for Public Health Nutrition market basket at affected and unaffected supermarket chain stores at three times: March 2015 (1-month pre-policy enactment), May 2015 (1-month post-policy enactment) and May 2016 (1-year post-policy enactment). Food items were categorized into four food processing groups, from minimally to ultra-processed...
February 7, 2018: Public Health Nutrition
https://www.readbyqxmd.com/read/29398592/age-adjusted-hematopoietic-stem-cell-transplant-comorbidity-index-predicts-survival-in-a-t-cell-depleted-cohort
#7
Hayder Saeed, Swati Yalamanchi, Meng Liu, Emily Van Meter, Zartash Gul, Gregory Monohan, Dianna Howard, Gerhard C Hildebrandt, Roger Herzig
OBJECTIVES: Allogeneic hematopoietic stem cell transplant (HCT) continues to evolve with the treatment in higher risk patient population. This practice mandates stringent update and validation of risk stratification prior to undergoing such a complex and potentially fatal procedure. We examined the adoption of the new comorbidity index (HCT-CI/Age) proposed by the Seattle group after the addition of age variable and compared it to the pre-transplant assessment of mortality (PAM) that already incorporates age as part of its evaluation criteria...
February 1, 2018: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/29397885/relation-of-age-and-health-related-quality-of-life-to-invasive-versus-ischemia-guided-management-of-patients-with-non-st-elevation-myocardial-infarction
#8
Krishna K Patel, Suzanne V Arnold, Philip G Jones, Mohammed Qintar, Karen P Alexander, John A Spertus
In older patients with non-ST-elevation myocardial infarction, an initial invasive strategy reduces cardiovascular events compared with an ischemia-guided approach; however its association with health status outcomes is unknown. Among patients with non-ST-elevation myocardial infarction from 2 multicenter US acute myocardial infarction (AMI) registries, health status was assessed at baseline and at 1, 6, and 12 months after AMI using the Seattle Angina Questionnaire (SAQ) and the 12-item Short-Form Health Survey (SF-12)...
January 10, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29395791/use-of-electronic-visibility-boards-to-improve-patient-care-quality-safety-and-flow-on-inpatient-pediatric-acute-care-units
#9
Mary Field, Krista Fong, Carol Shade
PURPOSE: Effective information exchange among healthcare providers is critical to the delivery of high quality care. Electronic visibility boards (EVB) are an established tool for improving health care efficiency and promoting communication between healthcare team members. DESIGN AND METHODS: Seattle Children's Hospital (SCH) sought to evaluate the use of EVBs as a tool to improve patient care quality, safety and flow in a pediatric inpatient setting. EVBs were placed on the cancer and surgical patient care units at SCH, and displayed data flowing directly from the electronic health record...
January 30, 2018: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/29390249/-professor-robin-a-j-eady-1940-2017-in-memoriam
#10
Natale G De Santo
On August 2, 2017 died in London Professor Robin A.J. Eady, retired professor of Dermatology and pioneer and long-lasting survivor in dialysis therapy. He had been diagnosed proteinuria at the age of 9 years and had started dialysis therapy in Seattle in 1963 under the care of Belding H. Scribner. Subsequently he had received dialysis in Edmonton (Canada) and at Royal Free Hospital in London. In 1987 he had received a successful renal transplant by Peter Morris, Professor of Surgery at Oxford. He had done well for 20 years...
February 2018: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/29388840/patient-perspectives-on-quality-and-access-to-healthcare-after-brain-injury
#11
Kristen Dams-O'Connor, Alexandra Landau, Jeanne Hoffman, Jef St De Lore
PRIMARY OBJECTIVE: To gather information about brain injury (BI) survivors' long-term healthcare needs, quality, barriers and facilitators. RESEARCH DESIGN: Qualitative content analysis of data gathered in focus groups using semi-structured interviews. METHODS: Forty-four community-dwelling adults participated at two clinical research centres in Seattle, Washington and New York, New York. Participants were asked open-ended questions about their experiences with healthcare in the community with regard to care needs, utilization, access, barriers and facilitators to health management...
February 1, 2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29381667/constipation-and-diarrhea-during-the-menopause-transition-and-early-postmenopause-observations-from-the-seattle-midlife-women-s-health-study
#12
Nini G L Callan, Ellen S Mitchell, Margaret M Heitkemper, Nancy F Woods
OBJECTIVE: To assess the relationship of constipation and diarrhea severity during the menopause transition (MT) with age, MT stage, reproductive biomarkers, stress-related biomarkers, and stress-related perceptions. METHODS: From 1990 to 1992, women aged 35 to 55 years were recruited from the greater Seattle area; 291 of them consented to ongoing (1990-2013) annual data collection by daily menstrual calendar, health diary, and annual health questionnaire. A subset (n = 131) provided a first morning voided urine specimen (1997-2013)...
January 29, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29377723/facial-expressiveness-in-infants-with-and-without-craniofacial-microsomia-preliminary-findings
#13
Zakia Hammal, Jeffrey F Cohn, Erin R Wallace, Carrie L Heike, Craig B Birgfeld, Harriet Oster, Matthew L Speltz
OBJECTIVE: To compare facial expressiveness (FE) of infants with and without craniofacial macrosomia (cases and controls, respectively) and to compare phenotypic variation among cases in relation to FE. DESIGN: Positive and negative affect was elicited in response to standardized emotion inductions, video recorded, and manually coded from video using the Facial Action Coding System for Infants and Young Children. SETTING: Five craniofacial centers: Children's Hospital of Los Angeles, Children's Hospital of Philadelphia, Seattle Children's Hospital, University of Illinois-Chicago, and University of North Carolina-Chapel Hill...
January 1, 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29372843/analysis-of-fusion-genes-by-nanostring-system-a-role-in-lung-cytology
#14
Greta Alì, Rossella Bruno, Mauro Savino, Riccardo Giannini, Serena Pelliccioni, Maura Menghi, Laura Boldrini, Agnese Proietti, Antonio Chella, Alessandro Ribechini, Gabriella Fontanini
CONTEXT: - Patients with non-small cell lung cancer harboring ALK receptor tyrosine kinase ( ALK), ROS proto-oncogene 1 ( ROS1), and ret proto-oncogene ( RET) gene rearrangements can benefit from specific kinase inhibitors. Detection of fusion genes is critical for determining the best treatment. Assessing rearrangements in non-small cell lung cancer remains challenging, particularly for lung cytology. OBJECTIVE: - To examine the possible application of the multiplex, transcript-based NanoString system (NanoString Technologies, Seattle, Washington) in the evaluation of fusion genes in lung adenocarcinoma samples...
January 26, 2018: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29354021/117th-annual-meeting-medical-library-association-inc-seattle-wa-may-26-31-2017
#15
Nicole Mitchell
No abstract text is available yet for this article.
January 2018: Journal of the Medical Library Association: JMLA
https://www.readbyqxmd.com/read/29346136/interdisciplinary-team-evaluation-an-effective-method-for-the-diagnostic-assessment-of-autism-spectrum-disorder
#16
Jennifer Gerdts, James Mancini, Emily Fox, Candace Rhoads, Tracey Ward, Erin Easley, Raphael A Bernier
OBJECTIVE: The objective of this research is to assess the feasibility of an interdisciplinary team diagnostic assessment model for autism spectrum disorder (ASD). METHOD: Medical records from 366 patients evaluated for ASD at the Seattle Children's Autism Center (SCAC) were reviewed. ASD diagnostic outcomes, provider satisfaction, engagement in follow-up care, billed time, and reimbursement amounts were compared in patients evaluated through an interdisciplinary team approach (n = 91) with those seen in multidisciplinary evaluations led by either a psychologist (n = 165) or a physician (n = 110)...
January 12, 2018: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/29343672/applying-the-seattle-heart-failure-model-in-the-office-setting-in-the-era-of-electronic-medical-records
#17
Brent A Williams, Shikhar Agarwal
BACKGROUND: Prediction models such as the Seattle Heart Failure Model (SHFM) can help guide management of heart failure (HF) patients, but the SHFM has not been validated in the office environment. This retrospective cohort study assessed the predictive performance of the SHFM among patients with new or pre-existing HF in the context of an office visit.Methods and Results:SHFM elements were ascertained through electronic medical records at an office visit. The primary outcome was all-cause mortality...
January 18, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29340297/acetic-acid-guided-biopsies-in-barrett-s-surveillance-for-neoplasia-detection-versus-non-targeted-biopsies-seattle-protocol-a-feasibility-study-for-a-randomized-tandem-endoscopy-trial-the-abba-study
#18
Fergus Chedgy, Carole Fogg, Kesavan Kandiah, Hugh Barr, Bernard Higgins, Mimi McCord, Ann Dewey, John De Caestecker, Lisa Gadeke, Clive Stokes, David Poller, Gaius Longcroft-Wheaton, Pradeep Bhandari
Background and study aims : Barrett's esophagus is a potentially pre-cancerous condition, affecting 375,000 people in the UK. Patients receive a 2-yearly endoscopy to detect cancerous changes, as early detection and treatment results in better outcomes. Current treatment requires random mapping biopsies along the length of Barrett's, in addition to biopsy of visible abnormalities. As only 13 % of pre-cancerous changes appear as visible nodules or abnormalities, areas of dysplasia are often missed...
January 2018: Endoscopy International Open
https://www.readbyqxmd.com/read/29337700/increased-resistance-to-tissue-plasminogen-activator-induced-fibrinolysis-in-healthy-subjects-from-thailand
#19
Nathan J White, Nicholas Taflin, Esther B Lim, Osaree Akaraborworn
: There is significant variability in blood coagulation among world populations. In particular, there may exist important differences in regulation of the fibrinolytic system in Asian populations that contribute to diseases of thrombosis and hemostasis. To investigate this issue, we compared fibrinogen concentration, plasma clot formation, and fibrinolytic resistance of healthy Asian subjects from Hat Yai, Songkhla, Thailand (Thai) vs. healthy North American subjects from Seattle, Washington, USA (SEA). Citrated plasma samples were obtained from healthy adult volunteers...
January 13, 2018: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/29335626/using-liver-elastography-to-diagnose-sinusoidal-obstruction-syndrome-in-pediatric-patients-undergoing-hematopoetic-stem-cell-transplant
#20
Naresh Reddivalla, Amie L Robinson, Kimberly J Reid, Mohamed A Radhi, Jignesh Dalal, Erin K Opfer, Sherwin S Chan
Sinusoidal obstruction syndrome (SOS) is a potentially fatal complication of hematopoietic stem cell transplantation (HSCT). Traditional ultrasound (US) has poor sensitivity and specificity. US shear wave elastography (SWE) is a newer technology that measures liver stiffness. This is a single-institution, prospective cohort study evaluating SWE in patients younger than 21 years who received HSCT from December 2015 through June 2017. SOS was defined using the modified Seattle criteria. Subjects had US with SWE at three scheduled time points...
January 15, 2018: Bone Marrow Transplantation
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