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https://www.readbyqxmd.com/read/28338921/the-relationship-between-objectively-measured-walking-and-risk-of-pedestrian-motor-vehicle-collision
#1
D Alex Quistberg, Eric J Howard, Philip M Hurvitz, Anne V Moudon, Beth E Ebel, Frederick P Rivara, Brian E Saelens
Safe urban walking environments may improve health by encouraging physical activity, but the relationship between an individual's location and walking pattern and the risk of pedestrian-motor vehicle collision is unknown. We examined associations between individuals' walking bouts and walking risk, measured as mean exposure to the risk of pedestrian-vehicle collision. Walking bouts were ascertained through integrated accelerometry and global positioning system data and from individual travel-diary data obtained from adults in the Travel Assessment and Community Study (King County, Washington) in 2008-2009...
March 1, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28329355/international-recommendations-for-electrocardiographic-interpretation-in-athletes
#2
Sanjay Sharma, Jonathan A Drezner, Aaron Baggish, Michael Papadakis, Mathew G Wilson, Jordan M Prutkin, Andre La Gerche, Michael J Ackerman, Mats Borjesson, Jack C Salerno, Irfan M Asif, David S Owens, Eugene H Chung, Michael S Emery, Victor F Froelicher, Hein Heidbuchel, Carmen Adamuz, Chad A Asplund, Gordon Cohen, Kimberly G Harmon, Joseph C Marek, Silvana Molossi, Josef Niebauer, Hank F Pelto, Marco V Perez, Nathan R Riding, Tess Saarel, Christian M Schmied, David M Shipon, Ricardo Stein, Victoria L Vetter, Antonio Pelliccia, Domenico Corrado
Sudden cardiac death (SCD) is the leading cause of mortality in athletes during sport. A variety of mostly hereditary, structural, or electrical cardiac disorders are associated with SCD in young athletes, the majority of which can be identified or suggested by abnormalities on a resting 12-lead electrocardiogram (ECG). Whether used for diagnostic or screening purposes, physicians responsible for the cardiovascular care of athletes should be knowledgeable and competent in ECG interpretation in athletes. However, in most countries a shortage of physician expertise limits wider application of the ECG in the care of the athlete...
February 20, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28323322/adaptations-following-an-intermittent-hypoxia-hyperoxia-training-in-coronary-artery-disease-patients-a-controlled-study
#3
Oleg Glazachev, Phylipp Kopylov, Davide Susta, Elena Dudnik, Elena Zagaynaya
BACKGROUND: Repeated exposure to intermittent normobaric hypoxia improves exercise tolerance in cardiac patients. Little is known on the effects of intermittent normobaric hypoxia-hyperoxia exposure in coronary artery disease (CAD) patients (New York Heart Association II-III). HYPOTHESIS: IHHT improves exercise tolerance, cardiometabolic profile, and quality of life in CAD patients. METHODS: The study design was a nonrandomized, controlled, before-and-after trial...
March 21, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28320996/feasibility-of-extracorporeal-shock-wave-myocardial-revascularization-therapy-for-post-acute-myocardial-infarction-patients-and-refractory-angina-pectoris-patients
#4
Masahiro Myojo, Jiro Ando, Masae Uehara, Masao Daimon, Masafumi Watanabe, Issei Komuro
Extracorporeal shockwave myocardial revascularization (ESMR) is one of the new treatment options for refractory angina pectoris (RAP), and some studies have indicated its effectiveness. A single-arm prospective trial to assess the feasibility of ESMR using Cardiospec for patients with post-acute myocardial infarction (AMI) and RAP was designed and performed. The patients were treated with 9 sessions of ESMR to the ischemic areas for 9 weeks. The feasibility measures included echocardiography; cardiac magnetic resonance imaging; troponin T, creatine kinase-MB (CK-MB), and brain natriuretic peptide testing; and a Seattle Angina Questionnaire (SAQ) survey...
March 21, 2017: International Heart Journal
https://www.readbyqxmd.com/read/28319834/molecular-mechanisms-in-the-pathogenesis-of-arrhythmogenic-cardiomyopathy
#5
REVIEW
Jeffrey E Saffitz
The article is based on work presented in the Distinguished Achievement Award lecture at the Society for Cardiovascular Pathology meeting in Seattle, WA, in March 2016. It reviews our current understanding of mechanisms responsible for a highly arrhythmogenic, nonischemic cardiomyopathy. It highlights the armamentarium of powerful methods available to the experimental pathologist in efforts to define how complex cardiovascular diseases work. It concludes with acknowledgment of the need for a far more detailed approach as to how we categorize human disease, a task for which pathologists are especially well positioned...
February 27, 2017: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/28314499/bringing-global-health-home-the-case-of-global-to-local-in-king-county-washington
#6
EDITORIAL
Adam Taylor, Fareeha Siddiqui
The article describes the experience of testing successful global health interventions in the cities of SeaTac and Tukwila, Washington-2 very diverse, underserved communities outside of Seattle that experience significant health disparities compared with surrounding areas in King County. Topics covered include an overview of the partnership that established Global to Local, the process of engaging Seattle-based global health institutions in identifying global health strategies to test, identifying communities experiencing health disparities that might benefit from global health-inspired interventions, engaging those local communities to understand the perceived drivers of poor health outcomes, tailoring global interventions to the local context, launching programs, and the successes and challenges that have emerged throughout this process...
November 2016: Annals of Global Health
https://www.readbyqxmd.com/read/28314495/global-service-learning-and-student-athletes-a-model-for-enhanced-academic-inclusion-at-the-university-of-washington
#7
Holly M Barker
BACKGROUND: The University of Washington (UW) continues to create opportunities to engage all students in transformational undergraduate educational opportunities, such as study abroad. OBJECTIVE: This article describes specific efforts to increase inclusion for student-athletes in study abroad, particularly for first-generation students, including low-income students of color. Given the overrepresentation of students of color in sports vis-à-vis the larger student body at predominantly white institutions (PWIs), like UW, service-learning in communities beyond campus boundaries provides opportunities to apply international learning to a local context and to create a continuum of learning...
November 2016: Annals of Global Health
https://www.readbyqxmd.com/read/28303005/ligand-co-crystallization-of-aminoacyl-trna-synthetases-from-infectious-disease-organisms
#8
Spencer O Moen, Thomas E Edwards, David M Dranow, Matthew C Clifton, Banumathi Sankaran, Wesley C Van Voorhis, Amit Sharma, Colin Manoil, Bart L Staker, Peter J Myler, Donald D Lorimer
Aminoacyl-tRNA synthetases (aaRSs) charge tRNAs with their cognate amino acid, an essential precursor step to loading of charged tRNAs onto the ribosome and addition of the amino acid to the growing polypeptide chain during protein synthesis. Because of this important biological function, aminoacyl-tRNA synthetases have been the focus of anti-infective drug development efforts and two aaRS inhibitors have been approved as drugs. Several researchers in the scientific community requested aminoacyl-tRNA synthetases to be targeted in the Seattle Structural Genomics Center for Infectious Disease (SSGCID) structure determination pipeline...
March 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28299240/validation-of-the-total-visual-acuity-extraction-algorithm-tova-for-automated-extraction-of-visual-acuity-data-from-free-text-unstructured-clinical-records
#9
Douglas M Baughman, Grace L Su, Irena Tsui, Cecilia S Lee, Aaron Y Lee
PURPOSE: With increasing volumes of electronic health record data, algorithm-driven extraction may aid manual extraction. Visual acuity often is extracted manually in vision research. The total visual acuity extraction algorithm (TOVA) is presented and validated for automated extraction of visual acuity from free text, unstructured clinical notes. METHODS: Consecutive inpatient ophthalmology notes over an 8-year period from the University of Washington healthcare system in Seattle, WA were used for validation of TOVA...
March 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/28285079/defibrotide-for-patients-with-hepatic-veno-occlusive-disease-sinusoidal-obstruction-syndrome-vod-sos-interim-results-from-a-treatment-ind-study
#10
Paul G Richardson, Angela R Smith, Brandon M Triplett, Nancy A Kernan, Stephan A Grupp, Joseph H Antin, Leslie Lehmann, Tsiporah Shore, Massimo Iacobelli, Maja Miloslavsky, Robin Hume, Alison L Hannah, Bijan Nejadnik, Robert J Soiffer
Hepatic veno-occlusive disease, or sinusoidal obstruction syndrome (VOD/SOS), is a serious and potentially fatal complication of conditioning for hematopoietic stem cell transplantation (HSCT) or of chemotherapy regimens alone. Defibrotide is a complex mixture of single-stranded polydeoxyribonucleotides that is approved in the United States for treatment of hepatic VOD/SOS with renal or pulmonary dysfunction post-HSCT and in the European Union, Israel, and South Korea for treatment of severe hepatic VOD/SOS post-HSCT...
March 8, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28279949/usability-and-acceptability-of-a-mobile-comprehensive-hiv-prevention-app-for-men-who-have-sex-with-men-a-pilot-study
#11
Patrick S Sullivan, Robert Driggers, Joanne D Stekler, Aaron Siegler, Tamar Goldenberg, Sarah J McDougal, Jason Caucutt, Jeb Jones, Rob Stephenson
BACKGROUND: Men who have sex with men (MSM) are the group most impacted by the human immunodeficiency virus (HIV) epidemic and the only subgroup in the United States among which new HIV diagnoses are not decreasing. To achieve the US National HIV/AIDS (acquired immunodeficiency syndrome) Strategy goals of reducing new diagnoses by 25%, high (eg, 30-50%) coverage of multiple HIV prevention interventions is needed in both urban and rural areas. Mobile phone "apps" are an important channel through which prevention services could be provided at scale and at low marginal cost...
March 9, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28279651/fracture-resistance-of-endodontically-treated-teeth-restored-with-short-fiber-composite-used-as-a-core-material-an-in-vitro-study
#12
Tejesh Gupta Garlapati, Jogikalmat Krithikadatta, Velmurugan Natanasabapathy
PURPOSE: This in-vitro study tested the fracture resistance of endodontically treated molars with Mesial-Occluso-Distal (MOD) cavities restored with fibre reinforced composite material everX posterior in comparision with hybrid composite and ribbond fiber composite. MATERIALS AND METHODS: Fifty intact freshly extracted human mandibular first molars were collected and were randomly divided into five groups (n=10). Group 1: positive control (PC) intact teeth without any endodontic preparation...
March 6, 2017: Journal of Prosthodontic Research
https://www.readbyqxmd.com/read/28267958/comparison-of-multivariate-risk-estimation-models-to-predict-prognosis-in-patients-with-implantable-cardioverter-defibrillators-with-or-without-cardiac-resynchronization-therapy
#13
Salima Akoudad, Lara Dabiri Abkenari, Beat A Schaer, Christian Sticherling, Wayne C Levy, Luc Jordaens, Dominic A M J Theuns
Several multivariate risk score models were developed to predict prognosis of patients with heart failure (HF). We compared 3 models with regard to prediction of mortality in patients with HF who received an implantable defibrillator (ICD) or a cardiac resynchronization therapy defibrillator (CRT-D), as primary prevention of sudden death. The study cohort consisted of 823 patients (ICD = 410; CRT-D = 413). The evaluated models were the Seattle Heart Failure Model (SHFM), the Multicenter Automatic Defibrillator Implantation Trial II (MADIT II) score, and an adjusted Charlson Comorbidity Index (aCCI)...
February 10, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28266896/family-and-school-influences-on-youths-behavioral-and-academic-outcomes-cross-level-interactions-between-parental-monitoring-and-character-development-curriculum
#14
Namik Top, Jeffrey Liew, Wen Luo
The authors examined the joint (interactive) roles of the Second Step curriculum (a validated social-emotional learning and bullying prevention program; Committee for Children, Seattle, WA) and parenting practices on students' behavioral and academic outcomes in Grades 5-8. Participants were 763 parents and their children from 22 schools (8 control and 14 treatment). A 2-level random coefficient model was conducted to assess the effect of parental monitoring on school outcomes, as well as the interaction between character development curriculum and parental monitoring...
March 7, 2017: Journal of Genetic Psychology
https://www.readbyqxmd.com/read/28258178/international-criteria-for-electrocardiographic-interpretation-in-athletes
#15
Jonathan A Drezner, Sanjay Sharma, Aaron Baggish, Michael Papadakis, Mathew G Wilson, Jordan M Prutkin, Andre La Gerche, Michael J Ackerman, Mats Borjesson, Jack C Salerno, Irfan M Asif, David S Owens, Eugene H Chung, Michael S Emery, Victor F Froelicher, Hein Heidbuchel, Carmen Adamuz, Chad A Asplund, Gordon Cohen, Kimberly G Harmon, Joseph C Marek, Silvana Molossi, Josef Niebauer, Hank F Pelto, Marco V Perez, Nathan R Riding, Tess Saarel, Christian M Schmied, David M Shipon, Ricardo Stein, Victoria L Vetter, Antonio Pelliccia, Domenico Corrado
Sudden cardiac death (SCD) is the leading cause of mortality in athletes during sport. A variety of mostly hereditary, structural or electrical cardiac disorders are associated with SCD in young athletes, the majority of which can be identified or suggested by abnormalities on a resting 12-lead electrocardiogram (ECG). Whether used for diagnostic or screening purposes, physicians responsible for the cardiovascular care of athletes should be knowledgeable and competent in ECG interpretation in athletes. However, in most countries a shortage of physician expertise limits wider application of the ECG in the care of the athlete...
March 3, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28256283/cooking-at-home-a-strategy-to-comply-with-u-s-dietary-guidelines-at-no-extra-cost
#16
Arpita Tiwari, Anju Aggarwal, Wesley Tang, Adam Drewnowski
INTRODUCTION: Cooking at home is associated with better diet quality. This study examined the frequency of home-cooked dinners versus eating out in relation to the Healthy Eating Index (HEI), and food expenditures. METHODS: The Seattle Obesity Study used a stratified random sample of 437 King County adults. In-person computer-assisted interviews collected sociodemographic and behavioral data during 2011-2013. HEI-2010 and 2005 were computed using Food Frequency Questionnaires...
February 27, 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28246175/symptoms-and-quality-of-life-in-patients-with-suspected-angina-undergoing-ct-coronary-angiography-a-randomised-controlled-trial
#17
Michelle C Williams, Amanda Hunter, Anoop Shah, Valentina Assi, Stephanie Lewis, Kenneth Mangion, Colin Berry, Nicholas A Boon, Elizabeth Clark, Marcus Flather, John Forbes, Scott McLean, Giles Roditi, Edwin Jr van Beek, Adam D Timmis, David E Newby
BACKGROUND: In patients with suspected angina pectoris, CT coronary angiography (CTCA) clarifies the diagnosis, directs appropriate investigations and therapies, and reduces clinical events. The effect on patient symptoms is currently unknown. METHODS: In a prospective open-label parallel group multicentre randomised controlled trial, 4146 patients with suspected angina due to coronary heart disease were randomised 1:1 to receive standard care or standard care plus CTCA...
February 28, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28222305/consumer-use-and-understanding-of-labelling-information-on-edible-marijuana-products-sold-for-recreational-use-in-the-states-of-colorado-and-washington
#18
Katherine M Kosa, Kristen C Giombi, Caroline B Rains, Sheryl C Cates
BACKGROUND: In 2014, the states of Colorado and Washington began allowing retail sales of marijuana for recreational use. The regulatory agencies in these states have implemented specific labelling requirements for edible marijuana products sold for recreational use to help address concerns such as delayed activation time, accidental ingestion, and proper dosing. METHODS: We conducted 12 focus groups with 94 adult consumers and nonconsumers of edibles in Denver and Seattle to collect information on their use and understanding of labelling information on edible marijuana products sold for recreational use...
February 18, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28222123/deriving-effective-vaccine-allocation-strategies-for-pandemic-influenza-comparison-of-an-agent-based-simulation-and-a-compartmental-model
#19
Özden O Dalgıç, Osman Y Özaltın, William A Ciccotelli, Fatih S Erenay
Individuals are prioritized based on their risk profiles when allocating limited vaccine stocks during an influenza pandemic. Computationally expensive but realistic agent-based simulations and fast but stylized compartmental models are typically used to derive effective vaccine allocation strategies. A detailed comparison of these two approaches, however, is often omitted. We derive age-specific vaccine allocation strategies to mitigate a pandemic influenza outbreak in Seattle by applying derivative-free optimization to an agent-based simulation and also to a compartmental model...
2017: PloS One
https://www.readbyqxmd.com/read/28209349/frequency-of-and-significance-of-physical-frailty-in-patients-with-heart-failure
#20
Quin E Denfeld, Kerri Winters-Stone, James O Mudd, Shirin O Hiatt, Christopher V Chien, Christopher S Lee
Physical frailty is an important prognostic indicator in heart failure (HF); however, few studies have examined the relation between physical frailty and invasive hemodynamics among adults with HF. The purpose of this study was to characterize physical frailty in HF in relation to invasive hemodynamics. We enrolled 49 patients with New York Heart Association class II to IV HF when participants were scheduled for a right-sided cardiac heart catheterization procedure. Physical frailty was measured according to the "frailty phenotype": shrinking, weakness, slowness, physical exhaustion, and low physical activity...
April 15, 2017: American Journal of Cardiology
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