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https://www.readbyqxmd.com/read/29912782/a-randomized-triple-blind-trial-of-cardiac-shock-wave-therapy-on-exercise-tolerance-and-symptoms-in-patients-with-stable-angina-pectoris
#1
Evgeny Shkolnik, Greta Burneikaite, Gabrielius Jakutis, Mikhail Scherbak, Gitana Zuoziene, Birute Petrauskiene, Ekaterina Trush, Yury Vasyuk, Aleksandras Laucevicius, Jelena Celutkiene
BACKGROUND: Despite major advances in managing coronary artery disease and continuous research on alternative techniques to enhance myocardial perfusion and reduce symptoms, coronary artery disease is still one of the leading causes of adult disability worldwide. Cardiac shock-wave therapy (CSWT) has shown promising results in the amelioration of myocardial ischemia in experimental studies; however, clinical results are limited to single-center, mostly uncontrolled and underpowered trials...
June 16, 2018: Coronary Artery Disease
https://www.readbyqxmd.com/read/29911967/from-principles-to-practice-real-world-patient-and-stakeholder-engagement-in-breast-cancer-research
#2
Sarah M Greene, Susan Brandzel, Karen J Wernli
The Patient-Centered Outcomes Research Institute (PCORI) in Washington, DC, has catalyzed a meaningful shift in the composition of research project teams since its initial research funding cycle in 2011. Despite the influx of funding in the research community for patient-centered research, research on how to effectively engage patients and stakeholders in the research process is still relatively nascent. Kaiser Permanente Washington Health Research Institute (KPWHRI) in Seattle, WA, was an early recipient of PCORI research funding and, as of December 2017, has received 8 PCORI research awards totaling nearly $15 million...
June 6, 2018: Permanente Journal
https://www.readbyqxmd.com/read/29907621/heroin-use-is-associated-with-aa-type-kidney-amyloidosis-in-the-pacific-northwest
#3
Arjun Sharma, Priyanka Govindan, Mirna Toukatly, Jack Healy, Connor Henry, Steve Senter, Behzad Najafian, Bryan Kestenbaum
BACKGROUND AND OBJECTIVES: AA-type kidney amyloidosis is classically associated with chronic autoimmune or inflammatory disorders. However, some urban centers have reported a high prevalence of injection drug use among patients with kidney AA amyloidosis. Previous reports lack control groups to quantify associations and most predate the opioid epidemic in the United States. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We conducted a case-control study of 38 patients with biopsy-confirmed kidney AA amyloidosis and 72 matched control individuals without this condition from two large hospital systems in Seattle, Washington...
June 15, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29907134/clinical-outcome-and-physical-activity-measured-with-stepwatch-3%C3%A2-activity-monitor-after-minimally-invasive-total-hip-arthroplasty
#4
Steffen Höll, Andreas Blum, Georg Gosheger, Ralf Dieckmann, Corinna Winter, Dieter Rosenbaum
BACKGROUND: Subjective data and physical examinations of patients after total hip arthroplasty are used to assess the outcome. But regarding the physical activity, no objective data can be delivered by existing scores. The level of activity can be measured objectively by counting gait cycles. The aim of this study was to measure activity levels of patients before and after total hip arthroplasty (THA). METHODS: Forty-six patients were included in this prospective study...
June 15, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29905557/suspected-environmental-and-socio-economic-causes-of-diabetes-mellitus-and-associated-ocular-complications-in-the-sumy-region-ukraine-for-the-period-of-2011-2016
#5
S Lekishvili, B Chayen, S Chayen
The aim of the study was to compare and research: the general prevalence of DM in the Sumy region compared with the prevalence of DM in the whole of Ukraine during the years 2011-2016; the prevalence of ocular complications of diabetes and their tendency to progress in Ukraine and Sumy region over this period; various demographical traits of the prevalence of ocular complications of diabetes and the dependence of prevalence of ocular complications of diabetes upon environmental causes and various socio-economic factors...
May 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29894907/why-neighborhood-park-proximity-is-not-associated-with-total-physical-activity
#6
Orion T Stewart, Anne Vernez Moudon, Alyson J Littman, Edmund Seto, Brian E Saelens
This study explored how parks within the home neighborhood contribute to total physical activity (PA) by isolating park-related PA. Seattle-area adults (n = 634) were observed using time-matched accelerometer, Global Positioning System (GPS), and travel diary instruments. Of the average 42.3 min of daily total PA, only 11% was related to parks. Both home neighborhood park count and area were associated with park-based PA, but not with PA that occurred elsewhere, which comprised 89% of total PA. This study demonstrates clear benefits of neighborhood parks for contributing to park-based PA while helping explain why proximity to parks is rarely associated with overall PA...
June 9, 2018: Health & Place
https://www.readbyqxmd.com/read/29886471/-effect-of-percutaneous-coronary-intervention-and-medical-therapy-on-quality-of-life-and-cognitive-function-in-patients-with-coronary-heart-disease
#7
Fen Cao, Baojian Zhang, Xinyi Li, Shu Duan
To explore the effect and difference of percutaneous coronary intervention (PCI) and medical therapy on quality of life and cognitive function in patients with coronary heart disease (CHD), and to investigate the relationship between quality of life and cognitive function.
 Methods: A total of 320 patients with CHD, who underwent coronary angiography and PCI (PCI group, n=160), or underwent coronary angiography and medical therapy (drug therapy group, n=160), were selected. The quality of life was assessed by using the Health Survey Form SF-36 (SF-36) and the Seattle Angina Questionnaire (SAQ), and the cognitive function was assessed by using the Mini-Mental State Examination (MMSE)...
May 28, 2018: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/29883497/effect-of-ace-inhibition-on-coronary-microvascular-function-and-symptoms-in-normotensive-women-with-microvascular-angina-a-randomized-placebo-controlled-trial
#8
Marie Mide Michelsen, Anna Bay Rask, Elena Suhrs, Kristoffer Flintholm Raft, Nis Høst, Eva Prescott
OBJECTIVE: Studies have suggested a beneficial effect of angiotensin-converting enzyme (ACE) inhibition. To explore whether the ACE inhibitor ramipril has a direct effect on the microvasculature beyond the blood pressure (BP) lowering effect, we investigated whether ramipril improved coronary microvascular function in normotensive women with coronary microvascular dysfunction (CMD). METHODS: We included 63 normotensive women with angina, no epicardial stenosis>50% and CMD defined as a coronary flow velocity reserve (CFVR)<2...
2018: PloS One
https://www.readbyqxmd.com/read/29873895/defibrotide-for-the-treatment-of-hepatic-veno-occlusive-disease-sinusoidal-obstruction-syndrome-following-nontransplant-associated-chemotherapy-final-results-from-a-post-hoc-analysis-of-data-from-an-expanded-access-program
#9
Nancy A Kernan, Paul G Richardson, Angela R Smith, Brandon M Triplett, Joseph H Antin, Leslie Lehmann, Yoav Messinger, Wei Liang, Robin Hume, William Tappe, Robert J Soiffer, Stephan A Grupp
BACKGROUND: Hepatic veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) is a potentially fatal complication of conditioning for hematopoietic stem cell transplantation (HSCT) but can occur after nontransplant-associated chemotherapy. Following HSCT, VOD/SOS with multi-organ dysfunction (MOD) may be associated with >80% mortality. Defibrotide is approved to treat severe hepatic VOD/SOS post-HSCT in patients aged >1 month in the European Union and hepatic VOD/SOS with renal or pulmonary dysfunction post-HSCT in the United States...
June 6, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29872277/if-someone-cares-about-you-you-are-more-apt-to-come-around-improving-hiv-care-engagement-by-strengthening-the-patient-provider-relationship
#10
Troy J Wood, Kimberly A Koester, Katerina A Christopoulos, John A Sauceda, Torsten B Neilands, Mallory O Johnson
Purpose: The patient-provider relationship is a central factor that can promote or hinder long-term engagement in care among people living with chronic illnesses. In this paper, we explore characteristics of the patient-provider relationship that facilitated or hindered engagement in care among patients receiving care at HIV specialty clinics. Patients and methods: We conducted 6 focus group discussions with a total of 43 well-retained and less well-retained HIV+ patients in San Francisco, Seattle, and Birmingham, to elicit a wide range of perspectives on engagement in HIV care...
2018: Patient Preference and Adherence
https://www.readbyqxmd.com/read/29872248/catheter-directed-thrombolysis-for-submassive-pulmonary-embolism
#11
REVIEW
Matthew A Chiarello, Akhilesh K Sista
Acute pulmonary embolism (PE) is a leading cause of morbidity and mortality in the United States. PE associated with right ventricular strain, termed submassive or intermediate-risk PE, is associated with an increased rate of clinical deterioration and short-term mortality. Trials have demonstrated systemic thrombolytics may improve patient outcomes, but they carry a risk of major hemorrhage. Catheter-directed thrombolysis (CDT) may offer similar efficacy to and a lower risk of catastrophic hemorrhage than systemic thrombolysis...
June 2018: Seminars in Interventional Radiology
https://www.readbyqxmd.com/read/29870023/structure-and-analysis-of-nucleoside-diphosphate-kinase-from-borrelia-burgdorferi-prepared-in-a-transition-state-complex-with-adp-and-vanadate-moieties
#12
Mitchell Dumais, Douglas R Davies, Tao Lin, Bart L Staker, Peter J Myler, Wesley C Van Voorhis
Nucleoside diphosphate kinases (NDKs) are implicated in a wide variety of cellular functions owing to their enzymatic conversion of NDP to NTP. NDK from Borrelia burgdorferi (BbNDK) was selected for functional and structural analysis to determine whether its activity is required for infection and to assess its potential for therapeutic inhibition. The Seattle Structural Genomics Center for Infectious Diseases (SSGCID) expressed recombinant BbNDK protein. The protein was crystallized and structures were solved of both the apoenzyme and a liganded form with ADP and vanadate ligands...
June 1, 2018: Acta Crystallographica. Section F, Structural Biology Communications
https://www.readbyqxmd.com/read/29866459/gdf-15-galectin-3-soluble-st2-and-risk-of-mortality-and-cardiovascular-events-in-ckd
#13
Courtney Tuegel, Ronit Katz, Mariam Alam, Zeenat Bhat, Keith Bellovich, Ian de Boer, Frank Brosius, Crystal Gadegbeku, Debbie Gipson, Jennifer Hawkins, Jonathan Himmelfarb, Wenjun Ju, Bryan Kestenbaum, Matthias Kretzler, Cassianne Robinson-Cohen, Susan Steigerwalt, Nisha Bansal
RATIONALE & OBJECTIVE: Inflammation, cardiac remodeling, and fibrosis may explain in part the excess risk for cardiovascular disease (CVD) in patients with chronic kidney disease (CKD). Growth differentiation factor 15 (GDF-15), galectin 3 (Gal-3), and soluble ST2 (sST2) are possible biomarkers of these pathways in patients with CKD. STUDY DESIGN: Observational cohort study. SETTING & PARTICIPANTS: Individuals with CKD enrolled in either of 2 multicenter CKD cohort studies: the Seattle Kidney Study or C-PROBE (Clinical Phenotyping and Resource Biobank Study)...
June 1, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29858905/a-novel-mutation-in-the-proopiomelanocortin-pomc-gene-of-a-hispanic-child-metformin-treatment-shows-a-beneficial-impact-on-the-body-mass-index
#14
Mark A Hilado, Ruvdeep S Randhawa
BACKGROUND: Proopiomelanocortin (POMC) is a complex polypeptide that produces a variety of biologically active substances via cleavage in a tissue-specific manner [Challis BG, Millington GW. Proopiomelanocortin deficiency. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle, 1993-2018], yielding several products including adrenocorticotrophic (ACTH) and melanocyte stimulating hormones (MSH). These peptides have roles in the regulation of food intake, energy homeostasis, adrenal steroidogenesis, melanocyte stimulation and immune modulation...
June 2, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29847326/training-pediatricians-to-address-health-disparities-an-innovative-residency-track-combining-global-health-with-community-pediatrics-and-advocacy
#15
Suzinne Pak-Gorstein, Maneesh Batra, Brian Johnston, H Mollie Grow, Abigail Grant, Richard Shugerman, Sylvia Lago, F Bruder Stapleton, Heather McPhillips
PROBLEM: Pediatric residency programs have been tasked to train a workforce of pediatricians with skills in community pediatrics and advocacy, and knowledge of global child health priorities. APPROACH: In 2009, the University of Washington (UW) Seattle Children's Hospital pediatric residency program developed the Resident Education in Advocacy and Child Health (REACH) program, a combined pathway for global health (GH) and community pediatric (CP) training. After participating in a combined curriculum, residents complete a community immersion either in Kisii, Kenya (GH) or rural Washington (CP)...
May 29, 2018: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29806748/review-of-current-care-models-for-transgender-youth-and-application-to-the-development-of-a-multidisciplinary-clinic-the-seattle-children-s-hospital-experience
#16
Parisa Salehi, Sara A Divall, Julia M Crouch, Rebecca A Hopkinson, Leah Kroon, Jennifer Lawrence, Benjamin S Wilfond, David J Inwards-Breland
Care of transgender and gender diverse youth is complex and requires a multidisciplinary approach. Many transgender patients and providers feel the limited availability of affirming, knowledgeable professionals is a barrier to obtaining care. Such care can be provided through a clinic with providers from different disciplines who are trained in the unique care of transgender youth. In this paper, we discuss the care guidelines for transgender youth and the unresolved challenges that need to be addressed during the development of a transgender clinic...
April 2018: Pediatric Endocrinology Reviews: PER
https://www.readbyqxmd.com/read/29804905/tucatinib-with-capecitabine-and-trastuzumab-in-advanced-her2-positive-metastatic-breast-cancer-with-and-without-brain-metastases-a-non-randomised-open-label-phase-1b-study
#17
Rashmi Murthy, Virginia F Borges, Alison Conlin, Jorge Chaves, Marc Chamberlain, Todd Gray, Alex Vo, Erika Hamilton
BACKGROUND: Tucatinib is a potent and selective oral HER2 tyrosine kinase inhibitor, with the potential to provide a well tolerated new treatment option for patients whose disease has progressed on currently available therapies. We aimed to determine the recommended phase 2 dose, safety, pharmacokinetics, and preliminary activity of tucatinib in combination with capecitabine or trastuzumab in patients with HER2-positive breast cancer with or without brain metastases. METHODS: In this non-randomised, open-label, phase 1b trial done in five sites in the USA, we recruited patients aged 18 years or older with HER2-positive progressive breast cancer who had been previously treated with trastuzumab, pertuzumab, and trastuzumab emtansine...
May 24, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29803987/rationale-and-design-of-the-british-heart-foundation-bhf-coronary-microvascular-angina-cormica-stratified-medicine-clinical-trial
#18
Thomas J Ford, David Corcoran, Keith G Oldroyd, Margaret McEntegart, Paul Rocchiccioli, Stuart Watkins, Katriona Brooksbank, Sandosh Padmanabhan, Naveed Sattar, Andrew Briggs, Alex McConnachie, Rhian Touyz, Colin Berry
BACKGROUND: Coronary angiography is performed to assess for obstructive coronary artery disease (CAD), but "nonobstructive CAD" is a common finding. Microvascular or vasospastic angina may be relevant, but routine confirmatory testing is not evidence based and thus rarely performed. AIM: The aim was to assess the effect of stratified medicine guided by coronary function testing on the diagnosis, treatment, and well-being of patients with angina and nonobstructive CAD...
July 2018: American Heart Journal
https://www.readbyqxmd.com/read/29803752/a-novel-ultrasonographic-scoring-system-of-sinusoidal-obstruction-syndrome-after-hematopoietic-stem-cell-transplantation
#19
Mutsumi Nishida, Kaoru Kahata, Eiko Hayase, Akio Shigematsu, Megumi Sato, Yusuke Kudo, Satomi Omotehara, Takahito Iwai, Junichi Sugita, Hitoshi Shibuya, Chikara Shimizu, Takanori Teshima
BACKGROUND: Sinusoidal obstruction syndrome (SOS)/hepatic veno-occlusive disease (VOD) is a well-documented complication after hematopoietic stem cell transplantation (HSCT). Transabdominal ultrasonography (US) enables to visualize blood flow abnormalities and is therefore useful for the diagnosis of SOS/VOD. We herein prospectively evaluated accuracy of a novel ultrasonographic diagnostic scoring system of SOS/VOD based on US findings. METHODS: We carried out US in 106 patients on day 14 and when SOS/VOD was suspected after allogeneic HSCT...
May 24, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29802550/building-the-case-for-localized-approaches-to-hiv-structural-conditions-and-health-system-capacity-to-address-the-hiv-aids-epidemic-in-six-us-cities
#20
D Panagiotoglou, M Olding, B Enns, D J Feaster, C Del Rio, L R Metsch, R M Granich, S A Strathdee, B D L Marshall, M R Golden, S Shoptaw, B R Schackman, B Nosyk
Since the discovery of the secondary preventive benefits of antiretroviral therapy, national and international governing bodies have called for countries to reach 90% diagnosis, ART engagement and viral suppression among people living with HIV/AIDS. The US HIV epidemic is dispersed primarily across large urban centers, each with different underlying epidemiological and structural features. We selected six US cities, including Atlanta, Baltimore, Los Angeles, Miami, New York, and Seattle, with the objective of demonstrating the breadth of epidemiological and structural differences affecting the HIV/AIDS response across the US...
May 25, 2018: AIDS and Behavior
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