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https://www.readbyqxmd.com/read/29451946/first-experience-in-switzerland-in-phe508del-homozygous-cystic-fibrosis-patients-with-end-stage-pulmonary-disease-enrolled-in-a-lumacaftor-ivacaftor-therapy-trial-preliminary-results
#1
Christian Murer, Lars Christian Huber, Thomas Kurowski, Astrid Hirt, Cécile A Robinson, Urs Bürgi, Christian Benden
AIMS OF THE STUDY: Cystic fibrosis is the most common genetic disorder in Caucasians. The combination of the cystic fibrosis transmembrane conductance regulator (CFTR) corrector lumacaftor / potentiator ivacaftor (LUM/IVA) has been shown to increase forced expiratory volume in 1 second (FEV1) moderately, but predominantly reduce acute exacerbation rate (AER) in Phe508del homozygous cystic fibrosis patients; however, patients with FEV1 <40% predicted were excluded from studies. We used LUM/IVA on a "compassionate use" basis in cystic fibrosis patients with end-stage pulmonary disease...
February 16, 2018: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29447839/consensus-statement-on-the-need-for-innovation-transition-and-implementation-of-developmental-neurotoxicity-dnt-testing-for-regulatory-purposes
#2
Ellen Fritsche, Philippe Grandjean, Kevin M Crofton, Michael Aschner, Alan Goldberg, Tuula Heinonen, Ellen V S Hessel, Helena Hogberg, Susanne Hougaard Bennekou, Pamela J Lein, Marcel Leist, William R Mundy, Martin Paparella, Aldert H Piersma, Magdalini Sachana, Gabriele Schmuck, Roland Solecki, Andrea Terron, Florianne Monnet-Tschudi, Martin F Wilks, Hilda Witters, Marie-Gabrielle Zurich, Anna Bal-Price
This consensus statement voices the agreement of scientific stakeholders from regulatory agencies, academia and industry that a new framework needs adopting for assessment of chemicals with the potential to disrupt brain development. An increased prevalence of neurodevelopmental disorders in children has been observed that cannot solely be explained by genetics and recently pre- and postnatal exposure to environmental chemicals has been suspected as a causal factor. There is only very limited information on neurodevelopmental toxicity, leaving thousands of chemicals, that are present in the environment, with high uncertainty concerning their developmental neurotoxicity (DNT) potential...
February 12, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29444748/aortopulmonary-collaterals-in-neonates-with-d-transposition-of-the-great-arteries-clinical-significance-early-after-arterial-switch-operation
#3
Alexandra Wipf, Martin Christmann, Susanne Navarini-Meury, Hitendu Dave, Daniel Quandt, Walter Knirsch, Oliver Kretschmar
OBJECTIVES: Purpose of this study is to evaluate the clinical significance of major aortopulmonary collateral arteries (MAPCAs) during the early postoperative course after arterial switch operation (ASO) in d-transposition of the great arteries (dTGA). METHODS: Clinical data of 98 patients with simple dTGA between January 2007 and December 2016 at the University Children's Hospital Zurich, Switzerland were analyzed retrospectively. RESULTS: 37 from 98 patients (38%) required cardiac catheterization (CC) due to an early complicated postoperative course or difficult coronary transfer due to special coronary anatomy...
February 2, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29441693/epidemiology-of-fractures-the-role-of-kick-injuries-in-equine-fractures
#4
B Donati, A E Fürst, M Hässig, M A Jackson
BACKGROUND: Fractures occur commonly in equids and often are associated with complications and a poor outcome. There are no reports on the epidemiology of fractures in a heterogeneous equine population. OBJECTIVES: To study the epidemiology of fractures in a heterogeneous equine population, focusing on differences between fractures resulting from a kick and fractures resulting from other causes and investigating predictors for recovery. STUDY DESIGN: Retrospective case series...
February 14, 2018: Equine Veterinary Journal
https://www.readbyqxmd.com/read/29434645/atopy-and-related-clinical-symptoms-among-swiss-medical-students-from-2007-to-2015
#5
Lukas Steinegger, Stephan Regenass, Lucas M Bachmann, Elsbeth Probst, Urs C Steiner
Background: Atopic allergy is a widespread disease with increasing prevalence in the second half of the twentieth century and is most often associated with clinical symptoms, like rhinoconjunctivitis, asthma or eczema. This study explored the prevalence of atopy and polysensitization in nine cohorts of Swiss medical students during the period of 2007-2015. Furthermore, the self-reported allergic symptoms, such as rhinoconjunctivitis, asthma and eczema, among students with and without atopy were assessed...
2018: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/29427041/the-validity-of-parental-reports-on-motor-skills-performance-level-in-preschool-children-a-comparison-with-a-standardized-motor-test
#6
Annina E Zysset, Tanja H Kakebeeke, Nadine Messerli-Bürgy, Andrea H Meyer, Kerstin Stülb, Claudia S Leeger-Aschmann, Einat A Schmutz, Amar Arhab, Valentina Ferrazzini, Susi Kriemler, Simone Munsch, Jardena J Puder, Oskar G Jenni
Motor skills are interrelated with essential domains of childhood such as cognitive and social development. Thus, the evaluation of motor skills and the identification of atypical or delayed motor development is crucial in pediatric practice (e.g., during well-child visits). Parental reports on motor skills may serve as possible indicators to decide whether further assessment of a child is necessary or not. We compared parental reports on fundamental motor skills performance level (e.g., hopping, throwing), based on questions frequently asked in pediatric practice, with a standardized motor test in 389 children (46...
February 9, 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29422881/encouragement-induced-real-world-upper-limb-use-after-stroke-by-a-tracking-and-feedback-device-a-study-protocol-for-a-multi-center-assessor-blinded-randomized-controlled-trial
#7
Jeremia P O Held, Andreas R Luft, Janne M Veerbeek
Introduction: Retraining the paretic upper limb after stroke should be intense and specific to be effective. Hence, the best training is daily life use, which is often limited by motivation and effort. Tracking and feedback technology have the potential to encourage self-administered, context-specific training of upper limb use in the patients' home environment. The aim of this study is to investigate post-intervention and long-term effects of a wrist-worn activity tracking device providing multimodal feedback on daily arm use in hemiparetic subjects beyond 3 months post-stroke...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29417258/impact-of-comorbidities-at-diagnosis-on-prostate-cancer-treatment-and-survival
#8
Katarina Luise Matthes, Manuela Limam, Giulia Pestoni, Leonhard Held, Dimitri Korol, Sabine Rohrmann
BACKGROUND: The aim of this study was to assess the associations of comorbidities with primary treatment of prostate cancer (PCa) patients and of comorbidities with PCa-specific mortality (PCSM) compared to other-cause mortality (OCM) in Switzerland. PATIENTS AND METHODS: We included 1527 men diagnosed with PCa in 2000 and 2001 in the canton of Zurich. Multiple imputation methods were applied to missing data for stage, grade and comorbidities. Multinomial logistic regression analyses were used to explore the associations of comorbidities with treatment...
February 7, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29414817/attitudes-towards-personal-genomics-and-sharing-of-genetic-data-among-older-swiss-adults-a-qualitative-study
#9
Laura Mählmann, Sebastian Schee Gen Halfmann, Agnes von Wyl, Angela Brand
OBJECTIVE: To assess the willingness of older Swiss adults to share genetic data for research purposes and to investigate factors that might impact their willingness to share data. METHODS: Semi-structured interviews were conducted among 40 participants (19 male and 21 female) aged between 67 and 92 years, between December 2013 and April 2014 attending the Seniorenuniversität Zürich, Switzerland. All interviews were audio-recorded, transcribed verbatim, and anonymized...
February 7, 2018: Public Health Genomics
https://www.readbyqxmd.com/read/29403579/computed-tomography-as-primary-postoperative-follow-up-after-laparoscopic-roux-en-y-gastric-bypass
#10
Tarik Delko, Diana Mattiello, Thomas Koestler, Urs Zingg, Silke Potthast
AIM: To evaluate upper abdominal computed tomography (CT) scan as primary follow-up after laparoscopic Roux-en-Y gastric bypass (LRYGB). METHODS: This prospective study was approved by the Ethical Committee of the State of Zurich, and informed consent was obtained from all patients. Sixty-one patients who underwent LRYGB received upper abdominal CT on postoperative day 1, with the following scan parameters: 0.6 mm collimation, 1.2 mm pitch, CareKV with reference 120 mAs and 120 kV, and 0...
January 28, 2018: World Journal of Radiology
https://www.readbyqxmd.com/read/29402271/effect-of-diagnosis-related-groups-implementation-on-the-intensive-care-unit-of-a-swiss-tertiary-hospital-a-cohort-study
#11
Lionel Chok, Esther B Bachli, Peter Steiger, Dominique Bettex, Silvia R Cottini, Emanuela Keller, Marco Maggiorini, Reto A Schuepbach
BACKGROUND: In 2013 the Swiss Diagnosis Related Groups ((Swiss)-DRG) was implemented in Intensive Care Units (ICU). Its impact on hospitalizations has not yet been examined. We compared the number of ICU admissions, according to clinical severity and referring institution, and screened whether implementation of Swiss-DRG affected admission policy, ICU length-of-stay (ICU-LOS) or ICU mortality. METHODS: Retrospective, single centre, cohort study conducted at the University Hospital Zurich, Switzerland between January 2009 and end of September 2013...
February 5, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29399458/treatment-of-osteochondral-lesions-of-the-talus-with-cell-free-polymer-based-scaffold-in-single-step-arthroscopic-surgery
#12
Ulunay Kanatlı, Ali Eren, Toygun K Eren, Abdurrahman Vural
Arthroscopic techniques have recently gained popularity for the treatment of osteochondral defects of the talus. The microfracture procedure is the most commonly applied arthroscopic technique. However, it is not effective for the treatment of larger lesions. Tissue-engineered scaffolds have been used for cartilage regeneration arthroscopically, and promising results have been reported. We treated larger osteochondral lesions of the talus with polyglycolic acid-hyaluronan scaffold biomaterial (Chondrotissue, BioTissue AG, Zurich, Switzerland) in a single-step arthroscopic surgery...
October 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/29395806/a-comparative-study-of-2-year-follow-up-outcomes-in-lumbar-spinal-stenosis-patients-treated-with-physical-therapy-alone-and-those-with-surgical-intervention-after-less-successful-physical-therapy
#13
Masakazu Minetama, Mamoru Kawakami, Masafumi Nakagawa, Yuyu Ishimoto, Keiji Nagata, Daisuke Fukui, Tadashi Sumiya, Tomoko Kitagawa, Takahiro Miyake, Yoshio Yamamoto, Nana Sakon, Toshiko Matsuoka, Yukihiro Nakagawa
BACKGROUND: The efficacy of physical therapy for patients with lumbar spinal stenosis (LSS) has been reported only for the short term, and few reports have compared outcomes of surgical treatment with nonsurgical treatment after physical therapy. The purpose of this study was to assess 2-year outcomes of LSS patients treated with surgery or under follow-up observation after physical therapy for 6 weeks. METHODS: Patients presenting with neurogenic claudication, radiologically-confirmed central LSS affecting both legs and refractory symptoms to pharmacotherapy of more than 3 months were enrolled...
January 29, 2018: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/29394383/safety-of-live-vaccines-on-immunosuppressive-or-immunomodulatory-therapy-a-retrospective-study-in-three-swiss-travel-clinics
#14
Fabienne Huber, Benoît Ehrensperger, Christoph Hatz, François Chappuis, Silja Bühler, Gilles Eperon
Background: Patients increasingly benefit from immunosuppressive/immunomodulatory medications for a range of conditions allowing them a lifestyle similar to healthy individuals, including travel. However, the administration of live vaccines to immunodeficient patients bears the risk of replication of the attenuated vaccine microorganism. Therefore, live vaccines are generally contraindicated on immunosuppression. Data on live vaccinations on immunosuppressive/immunomodulatory medication are scarce...
January 1, 2018: Journal of Travel Medicine
https://www.readbyqxmd.com/read/29391082/common-data-elements-for-concussion-in-tertiary-care-phase-one-in-ontario
#15
Cindy Hunt, Alicja Michalak, Donna Ouchterlony, Shawn Marshall, Cheryl Masanic, Chantal Vaidyanath, Shree Bhalerao, Michael D Cusimano, Deanna Quon, Lisa K Fischer, Andrew Baker
BACKGROUND: Standardized data collection for traumatic brain injury (TBI) (including concussion) using common data elements (CDEs) has strengthened clinical care and research capacity in the United States and Europe. Currently, Ontario healthcare providers do not collect uniform data on adult patients diagnosed with concussion. OBJECTIVE: The Ontario Concussion Care Strategy (OCCS) is a collaborative network of multidisciplinary healthcare providers, brain injury advocacy groups, patient representatives, and researchers with a shared vision to improve concussion care across the province, starting with the collection of standardized data...
November 2017: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/29385652/detecting-the-genomic-signal-of-polygenic-adaptation-and-the-role-of-epistasis-in-evolution
#16
Katalin Csilléry, Alejandra Rodríguez-Verdugo, Christian Rellstab, Frédéric Guillaume
Over the last decade, the genomic revolution has offered the possibility to generate tremendous amounts of data that contain valuable information on the genetic basis of phenotypic traits, such as those linked to human diseases or those that allow for species to adapt to a changing environment. Most ecologically relevant traits are controlled by a large number of genes with small individual effects on trait variation, but that are connected with one another through complex developmental, metabolic, and biochemical networks...
January 31, 2018: Molecular Ecology
https://www.readbyqxmd.com/read/29374473/epidemiology-of-gastrointestinal-symptoms-in-young-and-middle-aged-swiss-adults-prevalences-and-comorbidities-in-a-longitudinal-population-cohort-over-28%C3%A2-years
#17
Maria Avramidou, Felix Angst, Jules Angst, André Aeschlimann, Wulf Rössler, Ulrich Schnyder
BACKGROUND: Although subacute and chronic gastrointestinal symptoms are very common in primary care, epidemiological date are sparse. The aim of the study was to examine and quantify the prevalence of subacute and chronic gastrointestinal symptoms and their associations with somatic and mental disorders in the general population. METHODS: Data were collected prospectively between 1981 (age m = 22, f = 23) and 2008 (age 49/50) from the Zurich Cohort Study (n = 292 men, 299 women), a representative general population survey...
January 27, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29372860/prospective-randomized-multicenter-study-with-2-year-follow-up-to-compare-the-performance-of-decompression-with-and-without-interlaminar-stabilization
#18
Sven Schmidt, Joerg Franke, Michael Rauschmann, Dieter Adelt, Matteo Mario Bonsanto, Steffen Sola
OBJECTIVE Surgical decompression is extremely effective in relieving pain and symptoms due to lumbar spinal stenosis (LSS). Decompression with interlaminar stabilization (D+ILS) is as effective as decompression with posterolateral fusion for stenosis, as shown in a major US FDA pivotal trial. This study reports a multicenter, randomized controlled trial in which D+ILS was compared with decompression alone (DA) for treatment of moderate to severe LSS. METHODS Under approved institutional ethics review, 230 patients (1:1 ratio) randomized to either DA or D+ILS (coflex, Paradigm Spine) were treated at 7 sites in Germany...
January 26, 2018: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29351945/concurrent-endocrine-neoplasias-in-dogs-and-cats-a-retrospective-study-2004-2014
#19
Laura Beatrice, Felicitas Schär Boretti, Nadja S Sieber-Ruckstuhl, Claudia Mueller, Claudia Kümmerle-Fraune, Monika Hilbe, Paula Grest, Claudia E Reusch
Multiple endocrine neoplasia (MEN) is a well-known syndrome in human medicine, whereas only a few cases of concurrent endocrine neoplasias have been reported in dogs and cats. The aim of this study was to evaluate the prevalence of concurrent endocrine neoplasias in dogs and cats at our clinic, identify possible breed and sex predispositions and investigate similarities with MEN syndromes in humans. Postmortem reports of 951 dogs and 1155 cats that died or were euthanased at the Clinic for Small Animal Internal Medicine, University of Zurich, between 2004 and 2014 were reviewed, and animals with at least two concurrent endocrine neoplasias and/or hyperplasias were included...
January 19, 2018: Veterinary Record
https://www.readbyqxmd.com/read/29351748/a-comparative-study-of-three-conservative-treatments-in-patients-with-lumbar-spinal-stenosis-lumbar-spinal-stenosis-with-acupuncture-and-physical-therapy-study-lap-study
#20
Hiroyuki Oka, Ko Matsudaira, Yuichi Takano, Daichi Kasuya, Masaki Niiya, Juichi Tonosu, Masayoshi Fukushima, Yasushi Oshima, Tomoko Fujii, Sakae Tanaka, Hirohiko Inanami
BACKGROUND: Although the efficiency of conservative management for lumbar spinal stenosis (LSS) has been examined, different conservative management approaches have not been compared. We have performed the first comparative trial of three types of conservative management (medication with acetaminophen, exercise, and acupuncture) in Japanese patients with LSS. METHODS: Patients with L5 root radiculopathy associated with LSS who visited our hospital for surgical treatment were enrolled between December 2011 and January 2014...
January 19, 2018: BMC Complementary and Alternative Medicine
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