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https://www.readbyqxmd.com/read/28728092/checking-the-predictive-accuracy-of-basic-symptoms-against-ultra-high-risk-criteria-and-testing-of-a-multivariable-prediction-model-evidence-from-a-prospective-three-year-observational-study-of-persons-at-clinical-high-risk-for-psychosis
#1
M P Hengartner, K Heekeren, D Dvorsky, S Walitza, W Rössler, A Theodoridou
BACKGROUND: The aim of this study was to critically examine the prognostic validity of various clinical high-risk (CHR) criteria alone and in combination with additional clinical characteristics. METHODS: A total of 188 CHR positive persons from the region of Zurich, Switzerland (mean age 20.5 years; 60.2% male), meeting ultra high-risk (UHR) and/or basic symptoms (BS) criteria, were followed over three years. The test battery included the Structured Interview for Prodromal Syndromes (SIPS), verbal IQ and many other screening tools...
June 3, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28725187/lack-of-associations-between-female-hormone-levels-and-visuospatial-working-memory-divided-attention-and-cognitive-bias-across-two-consecutive-menstrual-cycles
#2
Brigitte Leeners, Tillmann H C Kruger, Kirsten Geraedts, Enrico Tronci, Toni Mancini, Fabian Ille, Marcel Egli, Susanna Röblitz, Lanja Saleh, Katharina Spanaus, Cordula Schippert, Yuangyuang Zhang, Michael P Hengartner
Background: Interpretation of observational studies on associations between prefrontal cognitive functioning and hormone levels across the female menstrual cycle is complicated due to small sample sizes and poor replicability. Methods: This observational multisite study comprised data of n = 88 menstruating women from Hannover, Germany, and Zurich, Switzerland, assessed during a first cycle and n = 68 re-assessed during a second cycle to rule out practice effects and false-positive chance findings. We assessed visuospatial working memory, attention, cognitive bias and hormone levels at four consecutive time-points across both cycles...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28724434/individual-contextual-factors-in-the-validation-of-the-bernese-pain-scale-for-neonates-protocol-for-a-prospective-observational-study
#3
Eva Cignacco, Karin Schenk, Bonnie Stevens, Liliane Stoffel, Dirk Bassler, Sven Schulzke, Mathias Nelle
BACKGROUND: The Bernese Pain Scale for Neonates (BPSN) is a multidimensional pain assessment tool that is already widely used in clinical settings in the German speaking areas of Europe. Recent findings indicate that pain responses in preterm neonates are influenced by individual contextual factors, such as gestational age (GA), gender and the number of painful procedures experienced. Currently, the BPSN does not consider individual contextual factors. Therefore, the aim of this study is the validation of the BPSN using a large sample of neonates with different GAs...
July 19, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28712426/negative-affect-is-unrelated-to-fluctuations-in-hormone-levels-across-the-menstrual-cycle-evidence-from-a-multisite-observational-study-across-two-successive-cycles
#4
Michael P Hengartner, Tillmann H C Kruger, Kirsten Geraedts, Enrico Tronci, Toni Mancini, Fabian Ille, Marcel Egli, Susanna Röblitz, Rainald Ehrig, Lanja Saleh, Katharina Spanaus, Cordula Schippert, Yuanyuan Zhang, Brigitte Leeners
BACKGROUND: Female sex hormones may play a crucial role in the occurrence of cycle-related mood disorders. However, the literature is inconsistent and methodologically stringent observational studies on the relationship between sex hormones and negative affect are lacking. METHODS: In this longitudinal multisite study from Hannover, Germany, and Zurich, Switzerland, we examined oestrogen, progesterone, luteinizing hormone (LH), follicle-stimulating hormone (FSH), and testosterone serum levels in association with negative affect as measured with the Positive and Negative Affect Schedule (PANAS)...
August 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28707420/transthoracic-intracardiac-catheters-in-pediatric-cardiac-patients-a-single-center-experience
#5
Kristoffer Beham, Hitendu Dave, Janet Kelly, Bernhard Frey, Maja I Hug, Barbara Brotschi
BACKGROUND: Transthoracic intracardiac catheters are frequently inserted in children during congenital heart surgery for monitoring and vascular access purposes. Their use entails a small potential risk. AIM: We aimed to evaluate both catheter-associated morbidities related to maintenance and removal of transthoracic intracardiac catheters in pediatric cardiac patients, and predictors for catheter-associated adverse events. METHODS: Single-center retrospective cohort study of prospectively collected data of children aged 0-14 years receiving a transthoracic intracardiac catheter inserted in the operating room during 7 consecutive years at the University Children's Hospital Zurich...
July 14, 2017: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/28699826/contralateral-associated-movements-correlate-with-inhibitory-control-and-selective-and-visual-attention-in-preschool-children
#6
Tanja H Kakebeeke, Nadine Messerli-Bürgy, Andrea H Meyer, Annina E Zysset, Kerstin Stülb, Claudia S Leeger-Aschmann, Einat A Schmutz, Amar Arhab, Jardena J Puder, Susi Kriemler, Simone Munsch, Oskar G Jenni
Contralateral associated movements (CAMs) frequently occur in complex motor tasks. We investigated whether and to what extent CAMs are associated with inhibitory control among preschool children in the Swiss Preschoolers' Health Study. Participants included 476 healthy, typically developing children (mean age = 3.88 years; 251 boys) and were evaluated on two consecutive afternoons. The children performed the Zurich Neuromotor Assessment, the statue subtest of the Neuropsychological Assessment for Children (NEPSY), and cognitive tests of the Intelligence and Development Scales-Preschool (IDS-P)...
January 1, 2017: Perceptual and Motor Skills
https://www.readbyqxmd.com/read/28697158/how-accurate-are-pediatric-emergency-tapes-a-comparison-of-4-emergency-tapes-with-different-length-based-weight-categorization
#7
Christian P Both, Achim Schmitz, Philipp K Buehler, Markus Weiss, Alexander R Schmidt
OBJECTIVE: Pediatric emergency tapes have been developed to support paramedics and emergency physicians when dosing drugs and selecting medical equipment in pediatric emergency situations. The aim of this study was to compare the accuracy of 4 pediatric emergency tapes to correctly estimate patient's weight based on a large population of patients. METHODS: Patients undergoing general anesthesia between January 2012 and March 2015 with documented age, sex, body weight, and length were identified from the electronic anesthesia patient data management system of the Department of Anaesthesia, University Children's Hospital, Zurich, Switzerland...
July 11, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28688227/impact-factors-on-cervical-dilation-rates-in-the-first-stage-of-labor
#8
Jana Juhasova, Martina Kreft, Roland Zimmermann, Nina Kimmich
AIMS: To assess cervical dilation rates of nulliparous and multiparous women in the active first stage of labor and to evaluate significant impact factors. METHODS: In a retrospective cohort study between January 2007 and July 2014 at the University Hospital of Zurich in Switzerland, we analyzed 8378 women with singleton pregnancies in vertex presentation with a vaginal delivery at 34+0 to 42+5 gestational weeks. Median cervical dilation rates were calculated and different impact factors evaluated...
July 8, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28684262/diagnostic-yield-of-high-resolution-manometry-with-a-solid-test-meal-for-clinically-relevant-symptomatic-oesophageal-motility-disorders-serial-diagnostic-study
#9
Daphne Ang, Benjamin Misselwitz, Michael Hollenstein, Kevin Knowles, Jeff Wright, Emily Tucker, Rami Sweis, Mark Fox
BACKGROUND: The use of high-resolution manometry (HRM) to diagnose oesophageal motility disorders is based on ten single water swallows (SWS); however, this approach might not be representative of oesophageal function during the ingestion of normal food. We tested whether inclusion of a standardised solid test meal (STM) to HRM studies increases test sensitivity for major motility disorders. Additionally, we assessed the frequency and cause of patient symptoms during STM. METHODS: Consecutive patients who were referred for investigation of oesophageal symptoms were recruited at Nottingham University Hospitals (Nottingham, UK) in the development study and at University Hospital Zürich (Zürich, Switzerland) in the validation study...
July 3, 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28684261/pharyngeal-swallowing-and-oesophageal-motility-during-a-solid-meal-test-a-prospective-study-in-healthy-volunteers-and-patients-with-major-motility-disorders
#10
Michael Hollenstein, Philip Thwaites, Simon Bütikofer, Henriette Heinrich, Matthias Sauter, Irina Ulmer, Daniel Pohl, Daphne Ang, Daniel Eberli, Werner Schwizer, Michael Fried, Oliver Distler, Mark Fox, Benjamin Misselwitz
BACKGROUND: The factors that determine how people eat when they are healthy or have disease have not been defined. We used high resolution manometry (HRM) to assess pharyngeal swallowing and oesophageal motility during ingestion of a solid test meal (STM) in healthy volunteers and patients with motility disorders. METHODS: This study was based at University Hospital Zurich (Zürich, Switzerland). Healthy volunteers who responded to an advertisement completed HRM with ten single water swallows (SWS) in recumbent and upright positions followed by a 200 g rice STM in the upright position...
July 3, 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28675796/negative-or-positive-the-iron-lung-and-poliomyelitis-zurich-1951
#11
T Eichel, M L Dreux
During the poliomyelitis epidemics of the last century hospitals were inundated with patients in acute respiratory failure. Between 1946 and 1949, Nandor (Ferdinand) Eichel documented the use of the iron lung in children with acute poliomyelitis at the University Children's Hospital, Zurich. The aim was to assess the effectiveness of the Iron lung and negative pressure respiratory support for this indication and to establish its role in the context of other existing therapies at the time. Eichel produced his review and data as the Inaugural Dissertation towards his medical degree from the the University of Zurich, published in 1951...
March 2017: Anaesthesia and Intensive Care
https://www.readbyqxmd.com/read/28670474/on-the-bridge-over-the-translational-valley-of-death-interview-with-per-i-arvidsson
#12
Per I Arvidsson
Per I Arvidsson speaks to Francesca Lake, Managing Editor: Per received his PhD in organic chemistry from Gothenburg University (Sweden) in 1999, where he continued as a lecturer for a short time. Following 2 years at the ETH Zurich (Switzerland) as a postdoctoral fellow, he went on to establish an independent research group at the Department of Biochemistry and Organic Chemistry at Uppsala University (Sweden). In 2006, he joined AstraZeneca R&D Södertälje (Sweden). After 1-year in-house training for future leaders in drug discovery and development, he became team leader in Medicinal Chemistry in 2007...
June 2017: Future Science OA
https://www.readbyqxmd.com/read/28667578/-who-benefits-from-the-night-clinic-value-of-a%C3%A2-part-time-treatment-facility
#13
Constanze Stutz, Wolfram Kawohl, Christoph Platz, Ingeborg Warnke, Matthias Jäger
BACKGROUND: The night clinic which is part of the psychiatric department of the University of Zurich is a part-time treatment option with psychiatric treatment and support in the evening. This study aimed to characterize the patients and detect different functions of the treatment setting. METHODS: Data of 253 patients covering a six-year period from 2008 up to 2013 were retrospectively assessed using descriptive methods. Subgroups according to the situation before admission and after discharge were compared...
June 30, 2017: Neuropsychiatrie: Klinik, Diagnostik, Therapie und Rehabilitation
https://www.readbyqxmd.com/read/28660955/computing-distance-distributions-from-dipolar-evolution-data-with-overtones-ridme-spectroscopy-with-gd-iii-based-spin-labels
#14
Katharina Keller, Valerie Mertens, Mian Qi, Anna I Nalepa, Adelheid Godt, Anton Savitsky, Gunnar Jeschke, Maxim Yulikov
Extraction of distance distributions between high-spin paramagnetic centers from relaxation induced dipolar modulation enhancement (RIDME) data is affected by the presence of overtones of dipolar frequencies. As previously proposed, we account for these overtones by using a modified kernel function in Tikhonov regularization analysis. This paper analyzes the performance of such an approach on a series of model compounds with the Gd(iii)-PyMTA complex serving as paramagnetic high-spin label. We describe the calibration of the overtone coefficients for the RIDME kernel, demonstrate the accuracy of distance distributions obtained with this approach, and show that for our series of Gd-rulers RIDME technique provides more accurate distance distributions than Gd(iii)-Gd(iii) double electron-electron resonance (DEER)...
July 21, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28660564/a-smartphone-application-to-determine-body-length-for-body-weight-estimation-in-children-a-prospective-clinical-trial
#15
Oliver Wetzel, Alexander R Schmidt, Michelle Seiler, Davide Scaramuzza, Burkhardt Seifert, Donat R Spahn, Philipp Stein
The aim of this study was to test the feasibility and accuracy of a smartphone application to measure the body length of children using the integrated camera and to evaluate the subsequent weight estimates. A prospective clinical trial of children aged 0-<13 years admitted to the emergency department of the University Children's Hospital Zurich. The primary outcome was to validate the length measurement by the smartphone application «Optisizer». The secondary outcome was to correlate the virtually calculated ordinal categories based on the length measured by the app to the categories based on the real length...
June 28, 2017: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/28655625/impact-of-city-police-layperson-education-and-equipment-with-automatic-external-defibrillators-on-patient-outcome-after-out-of-hospital-cardiac-arrest
#16
Philipp Stein, Gabriela H Spahn, Stefan Müller, Andreas Zollinger, Werner Baulig, Martin Brüesch, Burkhardt Seifert, Donat R Spahn
INTRODUCTION: Out of hospital cardiac arrest (OHCA) occurs frequently and the outcome is often dismal. Early defibrillation saves lives and brain function in OHCA. The Zurich city police (STAPO) forces were instructed and equipped to provide basic life support (BLS) and to use an AED in 2009. METHODS: Retrospective observational study comparing period 1 (P1) 2004-2009 before equipping and training of the STAPO and period 2 (P2) 2010-2015 after the implementation...
June 24, 2017: Resuscitation
https://www.readbyqxmd.com/read/28634970/severe-injection-site-reactions-after-subcutaneous-administration-of-sayana%C3%A2
#17
Annika M Jödicke, Hendrike Dahmke, Beat Damke, Martina Schäublin, Gerd A Kullak-Ublick, Stefan Weiler
PURPOSE: Sayana® was introduced as the first depot medroxyprogesterone acetate-containing contraceptive that is administered via subcutaneous injection. Within 10 months, the Regional Pharmacovigilance Centre (RPVC) Zurich received several anonymous reports of serious local reactions after Sayana® administration. In this retrospective study, individual case safety reports (ICSRs) on local adverse drug reactions (ADRs) related to Sayana® were analysed from the WHO pharmacovigilance database...
June 21, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/28633884/differences-in-practice-characteristics-between-male-and-female-chiropractors-in-switzerland
#18
Regina Vollenweider, Cynthia K Peterson, B Kim Humphreys
OBJECTIVES: A total of 75% of the chiropractic medicine students in the new program at the University of Zürich are women, which is in stark contrast to the traditional ratio of chiropractors in Switzerland, where 75% have been men. Therefore, the purpose of this study was to compare work behaviors between female and male chiropractors relating to workload, patient variety, and chiropractic treatment techniques. METHODS: This is a secondary analysis of data from the Swiss Job Analysis 2009 study...
June 17, 2017: Journal of Manipulative and Physiological Therapeutics
https://www.readbyqxmd.com/read/28627055/cholelithiasis-in-adult-bearded-dragons-retrospective-study-of-nine-adult-bearded-dragons-pogona-vitticeps-with-cholelithiasis-between-2013-and-2015-in-southern-germany
#19
A Gimmel, H Kempf, S Öfner, D Müller, A Liesegang
With an increased number of pet reptiles, many diseases occur due to nutritional disorders. Between 2013 and 2015, irregular gallbladder contents (sludge/choleliths) in adult bearded dragons (Pogona vitticeps) were recorded in many of the routinely conducted necropsies at the reptile rescue station in Munich (Auffangstation für Reptilien, München e.V., Munich, Germany). Nine animals, six from the rescue station and three from an associated veterinary practice (Tierärztliche Praxis für Exoten, Augsburg, Germany), were studied...
June 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28623596/impact-of-residency-training-level-on-the-surgical-quality-following-general-surgery-procedures
#20
Dominik Loiero, Maja Slankamenac, Pierre-Alain Clavien, Ksenija Slankamenac
OBJECTIVE: To investigate the safety of surgical performance by residents of different training level performing common general surgical procedures. METHODS: Data were consecutively collected from all patients undergoing general surgical procedures such as laparoscopic cholecystectomy, laparoscopic appendectomy, inguinal, femoral and umbilical hernia repair from 2005 to 2011 at the Department of Surgery of the University Hospital of Zurich, Switzerland. The operating surgeons were grouped into junior residents, senior residents and consultants...
June 16, 2017: World Journal of Surgery
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