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https://www.readbyqxmd.com/read/28110350/the-annual-scientific-meeting-of-the-european-society-of-musculoskeletal-radiology-essr-2016-in-zurich-switzerland-summary
#1
Marco Zanetti
The 23rd Annual Scientific Meeting of the European Society of Musculoskeletal Radiology (ESSR) 2016 in Switzerland, Zurich will be summarized.
January 22, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28109262/implementation-of-early-intensive-behavioural-intervention-for-children-with-autism-in-switzerland
#2
Nadja Studer, Ronnie Gundelfinger, Tanja Schenker, Hans-Christoph Steinhausen
BACKGROUND: There is a major gap between the US and most European countries regarding the implementation of early intensive behavioural intervention (EIBI) for children with autism. The present paper reports on the current status of EIBI in Switzerland and on the effectiveness of EIBI under clinical conditions in a Swiss pilot project. METHODS: The paper combines a narrative report of the care system for children with autism in Switzerland and an initial evaluation of EIBI as implemented in the Department of Child and Adolescent Psychiatry, University of Zurich...
January 21, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28102883/exploring-prognostic-factors-for-her2-positive-metastatic-breast-cancer-a-retrospective-cohort-study-in-a-major-swiss-hospital
#3
Lilian Bringolf, Bernhard Pestalozzi, Daniel Fink, Konstantin Dedes
BACKGROUND: Trastuzumab (Herceptin®, Roche) has significantly improved the prognosis of patients with HER2-positive metastatic breast cancer. Some patients remain in remission for many years. However, there are no prognostic markers associated with long-term survival. This study aimed to analyse treatment patterns of HER2-positive metastatic breast cancer at a single institution and explore prognostic factors for long-term survival after HER2-targeted treatment. PATIENTS AND METHODS: This was a retrospective cohort study of all patients with HER2-positive metastatic breast cancer receiving first-line treatment with HER2-targeted therapy between 2004 and 2014 at the University Hospital of Zurich (n = 81)...
January 19, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/28102131/profile-swiss-school-of-public-health-zurich-switzerland
#4
John Maurice
No abstract text is available yet for this article.
January 14, 2017: Lancet
https://www.readbyqxmd.com/read/28099318/low-endophthalmitis-rates-after-intravitreal-anti-vascular-endothelial-growth-factor-injections-in-an-operation-room-a-retrospective-multicenter-study
#5
Florentina J Freiberg, Troels Brynskov, Marion R Munk, Torben L Sørensen, Sebastian Wolf, Magdalena A Wirth, Matthias Becker, Stephan Michels
PURPOSE: To evaluate the rate of presumed endophthalmitis (EO) after intravitreal anti-vascular endothelial growth factor (anti-VEGF) injections in three European hospitals performed in an operation room (OR) under sterile conditions. METHODS: A retrospective multicenter study between 2003 and 2016 at three European sites, City Hospital Triemli Zurich, Switzerland (CHT), Zealand University Hospital Roskilde, Denmark (ZUH) and University Clinic Bern, Switzerland (UCB)...
January 17, 2017: Retina
https://www.readbyqxmd.com/read/28087747/zurich-international-symposium-on-arrhythmogenic-right-ventricular-cardiomyopathies
#6
Firat Duru, Corinna Brunckhorst
No abstract text is available yet for this article.
December 21, 2016: European Heart Journal
https://www.readbyqxmd.com/read/28077161/mathematical-modelling-of-echinococcus-multilocularis-abundance-in-foxes-in-zurich-switzerland
#7
Belen Otero-Abad, Simon R Rüegg, Daniel Hegglin, Peter Deplazes, Paul R Torgerson
BACKGROUND: In Europe, the red fox (Vulpes vulpes) is the main definitive host of Echinococcus multilocularis, the aetiological agent of a severe disease in humans called alveolar echinococcosis. The distribution of this zoonotic parasite among the fox population is remarkably aggregated with few heavily infected animals harbouring much of the parasite burdens and being responsible for most of the environmental parasitic egg contamination. Important research questions explored were: (i) spatial differences in parasite infection pressure related to the level of urbanization; (ii) temporal differences in parasite infection pressure in relation to time of the year; (iii) is herd immunity or an age-dependent infection pressure responsible for the observed parasite abundance; (iv) assuming E...
January 11, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28068614/the-gender-difference-in-depressive-prevalence-is-due-to-high-prevalence-of-somatic-depression-among-women-who-do-not-have-depressed-relatives
#8
Brett Silverstein, Vladeta Ajdacic-Gross, Wulf Rossler, Jules Angst
BACKGROUND: Given that several studies have found the gender difference in depression to be rooted in psychosocial forces and others have shown the difference to be due to a gender difference in somatic depression, we compared the gender difference in somatic depression among respondents who reported no relative depressed with that of all other depressed respondents. METHODS: Respondents in a representative sample from the Zurich study who met criteria for somatic depression and reported no relatives (first-degree, or parents, or mothers, or fathers in separate analyses) with depression were compared to other depressed respondents as to gender...
January 4, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28065915/effective-orifice-area-and-hemodynamic-performance-of-the-transcatheter-edwards-sapien-3-prosthesis-short-term-and-1-year-follow-up
#9
Mischa Külling, Jeremy Külling, Christophe Wyss, David Hürlimann, Ivano Reho, Sacha Salzberg, Ines Bühler, Georg Noll, Jürg Grünenfelder, Roberto Corti, Patric Biaggi
AIMS: The Edwards Sapien 3 heart valve prosthesis (S3) is commonly used for transcatheter aortic valve implantation (TAVI) and is available in three sizes. To date no data has been published on the effective orifice area (EOA) and the hemodynamic performance of the three different S3 sizes. The aim of this study was to measure the size-specific EOA and hemodynamic performance of the S3 in short-term and 1-year follow-up. METHODS AND RESULTS: One hundred and thirteen consecutive patients treated by TAVI with a S3 prosthesis at the Heart Clinic Zurich between May 2014 and July 2015 were included...
January 8, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28065908/ticagrelor-but-not-clopidogrel-active-metabolite-displays-antithrombotic-properties-in-the-left-atrial-endocardium
#10
Martin F Reiner, Alexander Breitenstein, Erik W Holy, Martina Glanzmann, Heidi Amstalden, Simon F Stämpfli, Nicole R Bonetti, Volkmar Falk, Stephan Keller, Gianluigi Savarese, Stefano Benussi, Francesco Maisano, Thomas F Lüscher, Jürg H Beer, Jan Steffel, Giovanni G Camici
AIMS: Oral anticoagulation is considered standard therapy for stroke prevention in atrial fibrillation (AF). Endocardial activation triggers expression of pro-thrombotic mediators including tissue factor (TF) and plasminogen activator inhibitor-1 (PAI-1), and contributes to thrombus formation in the left atrial appendage (LAA) of AF patients. Recently, pleiotropic effects of specific P2Y12 receptor antagonists were demonstrated; however, whether these drugs possess antithrombotic effects on LAA endocardial cells currently remains unknown...
January 8, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28063252/distribution-and-ecological-preferences-of-the-freshwater-lineage-lima-genus-limnohabitans-revealed-by-a-new-double-hybridisation-approach
#11
Tanja Shabarova, Vojtěch Kasalický, Karel Šimek, Jiří Nedoma, Petr Znachor, Thomas Posch, Jakob Pernthaler, Michaela M Salcher
The ecological relevance and factors shaping dynamics of Limnohabitans sp. have been largely studied by fluorescence in situ hybridisation (CARD-FISH) with a 16S rRNA probe targeting the R-BT group (lineages LimBCDE), but not lineage LimA. Consequently, ecology and distribution of LimA remained unknown. We developed a double hybridisation strategy using a novel 23S rRNA probe specifically targeting LimA and LimE that in combination with the existing R-BT probe can discriminate LimA populations. This technique was applied for more than 1000 samples from 46 freshwater sites including long-term data sets from oligomesotrophic Lake Zurich, CH and mesoeutrophic Římov reservoir, CZ...
January 7, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28057654/protocol-for-a-prospective-controlled-observational-study-to-evaluate-the-influence-of-hypoxia-on-healthy-volunteers-and-patients-with-inflammatory-bowel-disease-the-altitude-ibd-study
#12
Stephan Vavricka, Pedro A Ruiz, Sylvie Scharl, Luc Biedermann, Michael Scharl, Cheryl de Vallière, Carsten Lundby, Roland H Wenger, Leonhard Held, Tobias M Merz, Max Gassmann, Thomas Lutz, Andres Kunz, Denis Bron, Adriano Fontana, Laura Strauss, Achim Weber, Michael Fried, Gerhard Rogler, Jonas Zeitz
INTRODUCTION: Inflammatory bowel disease (IBD) is a chronic intestinal disorder, often leading to an impaired quality of life in affected patients. The importance of environmental factors in the pathogenesis of IBD, including their disease-modifying potential, is increasingly recognised. Hypoxia seems to be an important driver of inflammation, as has been reported by our group and others. The aim of the study is to evaluate if hypoxia can alter disease activity of IBD measured by Harvey-Bradshaw Activity Index in Crohn's disease (increase to ≥5 points) and the partial Mayo Score for ulcerative colitis (increase to ≥2 points)...
January 5, 2017: BMJ Open
https://www.readbyqxmd.com/read/28052642/differences-in-age-of-peak-marathon-performance-between-mountain-and-city-marathon-running-the-%C3%A2-jungfrau-marathon%C3%A2-in-switzerland
#13
Beat Knechtle, Pantelis Theodoros Nikolaidis, Matthias Alexander Zingg, Thomas Rosemann, Christoph Alexander Rüst
The age of the best marathon performance has been well investigated for flat city marathon running, but not for mountain marathon running. The aim of this study was to determine the age of the best mountain marathon performance and to compare to results of a flat city marathon. Race times and ages of finishers of a mountain marathon with 1,830 m of altitude change (Jungfrau Marathon, Switzerland) and two flat city marathons (Lausanne Marathon and Zurich Marathon, Switzerland) were analysed using linear, non-linear and mixed-effects regression analyses...
28, 2017: Chinese Journal of Physiology
https://www.readbyqxmd.com/read/28047431/su-f-r-51-radiomics-in-ct-perfusion-maps-of-head-and-neck-cancer
#14
M Nesteruk, O Riesterer, R Bundschuh, P Veit-Haibach, M Huellner, G Studer, S Stieb, S Glatz, M Pruschy, M Guckenberger, S Tanadini-Lang
PURPOSE: The aim of this study was to test the predictive value of radiomics features of CT perfusion (CTP) for tumor control, based on a preselection of radiomics features in a robustness study. METHODS: 11 patients with head and neck cancer (HNC) and 11 patients with lung cancer were included in the robustness study to preselect stable radiomics parameters. Data from 36 HNC patients treated with definitive radiochemotherapy (median follow-up 30 months) was used to build a predictive model based on these parameters...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046033/chronic-pain-how-challenging-are-ddis-in-the-analgesic-treatment-of-inpatients-with-multiple-chronic-conditions
#15
Klarissa Siebenhuener, Emmanuel Eschmann, Alexander Kienast, Dominik Schneider, Christoph E Minder, Reinhard Saller, Lukas Zimmerli, Jürg Blaser, Edouard Battegay, Barbara M Holzer
BACKGROUND: Chronic pain is common in multimorbid patients. However, little is known about the implications of chronic pain and analgesic treatment on multimorbid patients. This study aimed to assess chronic pain therapy with regard to the interaction potential in a sample of inpatients with multiple chronic conditions. METHODS AND FINDINGS: We conducted a retrospective study with all multimorbid inpatients aged ≥18 years admitted to the Department of Internal Medicine of University Hospital Zurich in 2011 (n = 1,039 patients)...
2017: PloS One
https://www.readbyqxmd.com/read/28002991/intraindividual-reaction-time-variability-predicts-prospective-memory-failures-in-older-adults
#16
B I Haynes, M Kliegel, D Zimprich, D Bunce
This study investigated the relationship between intraindividual variability (IIV) in reaction time and prospective memory errors in older adults using data from the Zurich Longitudinal Study of Cognitive Aging (n = 336 individuals aged 66-81 years). The results indicated that increased IIV measured from independent tasks was associated with a greater proportion of prospective memory errors. These significant findings were not influenced by age and did not vary according to prospective memory cue type. Variability is thought to reflect fluctuations in attentional and executive control and these attentional processes may also impact on prospective memory through failure to detect the target cue...
December 22, 2016: Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition
https://www.readbyqxmd.com/read/27994528/a-case-of-possible-chagas-transmission-by-blood-transfusion-in-switzerland
#17
Judith Ries, Adriana Komarek, Jochen Gottschalk, Birgit Brand, Lorenz Amsler, Markus Jutzi, Beat M Frey
BACKGROUND: Transfusion-transmitted Chagas disease has been reported from endemic countries in Latin America. Switzerland is a non-endemic country but high prevalence of antibodies against Trypanosoma cruzi was found among immigrants. Immigrants may participate in blood donation; therefore, risk-adapted anti-T. cruzi screening for blood donors was implemented in Switzerland in 2013. METHODS: Between January 2013 and July 2015, 1 out of 1,183 at-risk donors, tested at Blood Transfusion Service Zurich, was found anti-T...
November 2016: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/27993156/sensitivity-specificity-and-reproducibility-of-rna-seq-differential-expression-calls
#18
Paweł P Łabaj, David P Kreil
BACKGROUND: The MAQC/SEQC consortium has recently compiled a key benchmark that can serve for testing the latest developments in analysis tools for microarray and RNA-seq expression profiling. Such objective benchmarks are required for basic and applied research, and can be critical for clinical and regulatory outcomes. Going beyond the first comparisons presented in the original SEQC study, we here present extended benchmarks including effect strengths typical of common experiments. RESULTS: With artefacts removed by factor analysis and additional filters, for genome scale surveys, the reproducibility of differential expression calls typically exceed 80% for all tool combinations examined...
December 20, 2016: Biology Direct
https://www.readbyqxmd.com/read/27928880/a-novel-clinical-score-intertak-diagnostic-score-to-differentiate-takotsubo-syndrome-from-acute-coronary-syndrome-results-from-the-international-takotsubo-registry
#19
Jelena R Ghadri, Victoria L Cammann, Stjepan Jurisic, Burkhardt Seifert, L Christian Napp, Johanna Diekmann, Dana Roxana Bataiosu, Fabrizio D'Ascenzo, Katharina J Ding, Annahita Sarcon, Elycia Kazemian, Tanja Birri, Frank Ruschitzka, Thomas F Lüscher, Christian Templin
AIMS: Clinical presentation of takotsubo syndrome (TTS) mimics acute coronary syndrome (ACS) and does not allow differentiation. We aimed to develop a clinical score to estimate the probability of TTS and to distinguish TTS from ACS in the acute stage. METHODS AND RESULTS: Patients with TTS were recruited from the International Takotsubo Registry ( www.takotsubo-registry.com) and ACS patients from the leading hospital in Zurich. A multiple logistic regression for the presence of TTS was performed in a derivation cohort (TTS, n = 218; ACS, n = 436)...
December 7, 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/27926588/incidence-trends-and-clinical-pathological-characteristics-of-invasive-cutaneous-melanoma-from-1980-to-2010-in-the-canton-of-zurich-switzerland
#20
Remo Minini, Sabine Rohrmann, Ralph Braun, Dimitri Korol, Silvia Dehler
The aims of this paper are to describe the incidence trends of invasive cutaneous melanoma in the Canton of Zurich and to evaluate clinical and pathological factors such as cancer subtype, localization, age and Breslow thickness. A retrospective analysis was carried out with data from the population-based Cancer Registry of Zurich and Zug located in Zurich. A total of 8469 cases in 8034 different patients of invasive cutaneous melanoma were registered for the period 1980-2010 in the Canton of Zurich. Incidence trends were age standardized to the European standard population...
December 6, 2016: Melanoma Research
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