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https://www.readbyqxmd.com/read/27999534/striatal-dopaminergic-innervation-regulates-subthalamic-beta-oscillations-and-cortical-subcortical-coupling-during-movements-preliminary-evidence-in-subjects-with-parkinson-s-disease
#1
Andrea Canessa, Nicolò G Pozzi, Gabriele Arnulfo, Joachim Brumberg, Martin M Reich, Gianni Pezzoli, Maria F Ghilardi, Cordula Matthies, Frank Steigerwald, Jens Volkmann, Ioannis U Isaias
Activation of the basal ganglia has been shown during the preparation and execution of movement. However, the functional interaction of cortical and subcortical brain areas during movement and the relative contribution of dopaminergic striatal innervation remains unclear. We recorded local field potential (LFP) activity from the subthalamic nucleus (STN) and high-density electroencephalography (EEG) signals in four patients with Parkinson's disease (PD) off dopaminergic medication during a multi-joint motor task performed with their dominant and non-dominant hand...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27995072/application-of-texture-analysis-to-dat-spect-imaging-relationship-to-clinical-assessments
#2
Arman Rahmim, Yousef Salimpour, Saurabh Jain, Stephan A L Blinder, Ivan S Klyuzhin, Gwenn S Smith, Zoltan Mari, Vesna Sossi
Dopamine transporter (DAT) SPECT imaging is increasingly utilized for diagnostic purposes in suspected Parkinsonian syndromes. We performed a cross-sectional study to investigate whether assessment of texture in DAT SPECT radiotracer uptake enables enhanced correlations with severity of motor and cognitive symptoms in Parkinson's disease (PD), with the long-term goal of enabling clinical utility of DAT SPECT imaging, beyond standard diagnostic tasks, to tracking of progression in PD. Quantitative analysis in routine DAT SPECT imaging, if performed at all, has been restricted to assessment of mean regional uptake...
2016: NeuroImage: Clinical
https://www.readbyqxmd.com/read/27984256/cognition-in-patients-with-a-clinical-diagnosis-of-parkinson-disease-and-scans-without-evidence-of-dopaminergic-deficit-swedd-2-year-follow-up
#3
Kathryn A Wyman-Chick, Phillip K Martin, Michal Minár, Ryan W Schroeder
OBJECTIVE AND BACKGROUND: More than 10% of patients clinically diagnosed with Parkinson disease demonstrate normal dopamine uptake on dopamine transporter single-photon emission computed tomography (DaTscan), but little is known about how cognitive function differs between patients with dopamine deficiency on DaTscan and patients with scans without evidence of dopaminergic deficit (SWEDD). We compared the cognitive function of these two groups of patients over 2 years. METHODS: We retrospectively analyzed data obtained from the Parkinson's Progression Markers Initiative on 309 participants clinically diagnosed with idiopathic Parkinson disease who had scored in the normal range on the Montreal Cognitive Assessment at baseline and had completed 1- and 2-year follow-up visits...
December 2016: Cognitive and Behavioral Neurology: Official Journal of the Society for Behavioral and Cognitive Neurology
https://www.readbyqxmd.com/read/27980286/a-case-of-successful-treatment-with-donepezil-of-olfactory-hallucination-in-parkinson-disease
#4
Osamu Osada, Akira Iwasaki
We report a 74-year-old female patient with Parkinson disease (PD). Around 2010, she developed depression and bradykinesia and was diagnosed as PD. In July 2014, she came to our hospital, of which she lived in the neighborhood. In the last part of December 2014, she felt uneasy about her fecal smell and saw a psychiatrist in the first part of January 2015. Quetiapine (25 mg/day) was added. In the last part of January, she complained of fecal smell everywhere and could not take a meal. No-one else could detect the smell...
December 16, 2016: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/27941527/striatal-dopamine-transporter-modulation-after-rotigotine-results-from-a-pilot-single-photon-emission-computed-tomography-study-in-a-group-of-early-stage-parkinson-disease-patients
#5
Carlo Rossi, Dario Genovesi, Paolo Marzullo, Assuero Giorgetti, Elena Filidei, Giovanni Umberto Corsini, Ubaldo Bonuccelli, Roberto Ceravolo
INTRODUCTION: Several in vitro data have reported negative interference by dopamine-agonists on the expression of dopamine transporter (DAT), whereas the majority of imaging studies have shown that neither L-dopa nor dopamine-agonists interfere with DAT availability. As yet, there are no in vivo studies on DAT expression after treatment with rotigotine. METHODS: We evaluated presynaptic nigrostriatal function in 8 patients with de novo Parkinson disease (age, 59 ± 6...
January 2017: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/27941373/added-value-of-combined-semi-quantitative-and-visual-123i-fp-cit-spect-analyses-for-the-diagnosis-of-dementia-with-lewy-bodies
#6
Nicolas Nicastro, Valentina Garibotto, Gilles Allali, Frederic Assal, Pierre R Burkhard
PURPOSE OF THE REPORT: To assess the validity of a semi-quantitative I-FP-CIT SPECT method, compared to the commonly used visual analysis, in patients with probable dementia with Lewy bodies (DLB) and Alzheimer's disease (AD). We also studied DLB specific uptake impairment pattern and correlation of uptake in the presence or absence of parkinsonism. MATERIALS AND METHODS: Among 1202 scans performed at our center from 2003 to 2015, we identified 93 subjects with probable DLB (mean age 76...
December 9, 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27901100/imaging-analysis-of-parkinson-s-disease-patients-using-spect-and-tractography
#7
Seong-Jin Son, Mansu Kim, Hyunjin Park
Parkinson's disease (PD) is a degenerative disorder that affects the central nervous system. PD-related alterations in structural and functional neuroimaging have not been fully explored. This study explored multi-modal PD neuroimaging and its application for predicting clinical scores on the Movement Disorder Society-sponsored Unified Parkinson's Disease Rating Scale (MDS-UPDRS). Multi-modal imaging that combined (123)I-Ioflupane single-photon emission computed tomography (SPECT) and diffusion tensor imaging (DTI) were adopted to incorporate complementary brain imaging information...
November 30, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27897064/diagnosis-of-dementia-with-lewy-bodies-can-123-i-imp-and-123-i-mibg-scintigraphy-yield-new-core-features
#8
Fumi Sakamoto, Shinya Shiraishi, Noriko Tsuda, Mamoru Hashimoto, Seiji Tomiguchi, Manabu Ikeda, Yasuyuki Yamashita
OBJECTIVE: Since the clinical symptoms of different types of dementia frequently overlap, especially in the earlier stages at onset, it is difficult to distinguish dementias with Lewy bodies (DLB) from other neurodegenerative dementias based on their clinical manifestations alone. Nuclear medicine imaging has been reported as a high-value index for the objective evaluation and diagnosis of DLB. The aim of this study was to evaluate whether nuclear medicine imaging findings may yield core features to be added to the diagnosis of DLB...
November 29, 2016: British Journal of Radiology
https://www.readbyqxmd.com/read/27856628/analysis-of-extrastriatal-123i-fp-cit-binding-contributes-to-the-differential-diagnosis-of-parkinsonian-diseases
#9
Merijn Joling, Chris Vriend, Odile A Van den Heuvel, Pieter G H M Raijmakers, Paul A Jones, Henk W Berendse, Jan Booij
: (123)I-FP-CIT SPECT can visualise and quantify striatal dopamine transporter (DAT) binding in vivo. In addition, (123)I-FP-CIT has modest affinity for the serotonin transporter (SERT), predominantly represented in extrastriatal binding. Based on previous imaging studies that have suggested more pronounced degeneration of other monoaminergic systems in multiple system atrophy (MSA) and progressive supranuclear palsy (PSP) than in Parkinson's disease (PD), we hypothesised that, in addition to striatal DAT binding, there would be differences in extrastriatal (123)I-FP-CIT SPECT binding to SERT between MSA, PSP and PD...
November 17, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27833323/tc-99m-trodat-uptake-in-an-osteoid-tumor-of-clivus
#10
Sameer Taywade, Madhavi Tripathi, Vivek Tandon, Chandan Jyoti Das, Nishikant Avinash Damle, Shamim Ahmed Shamim, Parul Thukral, Chandrasekhar Bal
Tc-99m TRODAT is cocaine analog and binds to the dopamine transporter in vivo. Tc-99m TRODAT single-photon emission computed tomography/computed tomography. (SPECT/CT) is useful for demonstrating presynaptic dopaminergic dysfunction in patients with Parkinsonism. However, few reports have shown extrastriatal uptake of Tc-99m TRODAT. We present the case of a 67-year-old male who underwent Tc-99m TRODAT SPECT/CT for evaluation of Parkinsonism. In addition to tracer binding in the striatum, tracer uptake was noted in an osteoid tumor of the clivus...
October 2016: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/27813429/clinical-utility-of-datscan%C3%A2-imaging-in-the-evaluation-of-patients-with-parkinsonism-a-us-perspective
#11
Stuart H Isaacson, Stanley Fisher, Fiona Gupta, Neal Hermanowicz, Daniel E Kremens, Mark F Lew, Kenneth Marek, Rajesh Pahwa, David S Russell, John Seibyl
Single photon emission computed tomography (SPECT) with Ioflupane I123 injection (DaTscan™) was approved by the Food and Drug Administration in 2011 for striatal dopamine transporter visualization to assist in the evaluation of adult patients with suspected parkinsonian syndromes. While brain SPECT imaging using DaTscan is a covered service under Medicare policy, there is a lack of consensus on its role in routine clinical practice in the US. Areas covered: To address this issue, an expert group of US-based movement disorders neurologists convened to discuss the clinical utility of DaTscan in movement disorders practices within the US...
November 4, 2016: Expert Review of Neurotherapeutics
https://www.readbyqxmd.com/read/27775946/comparison-of-dopamine-transporter-spect-and-123i-mibg-myocardial-scintigraphy-to-assess-clinical-severity-in-patients-with-parkinson-disease
#12
Nanami Okano, Mamoru Niitsu, Junji Tanaka, Takahiro Sasaki, Kazushi Takahashi, Nobuo Araki, Toshimasa Yamamoto, Shintaro Nakano, Shigeyuki Nishimura, Takaaki Senbonmatsu, Ichiro Matsunari
PURPOSE: The aim of our study was to evaluate the use of dopamine transporter (DAT) SPECT and I-MIBG myocardial scintigraphy to determine the clinical severity of Parkinson disease (PD), with a focus on motor impairments affecting activities of daily living (ADLs). METHODS: Data for 65 consecutive PD patients who underwent both DAT and MIBG imaging were reviewed. Associations between imaging variables and Hoehn and Yahr (H&Y) staging or self-supportive care ratings were investigated...
January 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27772745/preserved-regional-cerebral-blood-flow-in-the-occipital-cortices-brainstem-and-cerebellum-of-patients-with-v180i-129m-genetic-creutzfeldt-jakob-disease-in-serial-spect-studies
#13
Yuichi Hayashi, Nobuaki Yoshikura, Akira Takekoshi, Megumi Yamada, Takahiko Asano, Akio Kimura, Katsuya Satoh, Tetsuyuki Kitamoto, Takashi Inuzuka
Creutzfeldt-Jakob disease (CJD) with a causative point mutation of valine to isoleucine at codon 180 (V180I) is one of the major types of genetic CJD (gCJD) in Japan. V180I gCJD is rarely accompanied by a family history, and its clinical characteristics include late-onset, long disease duration, and edematous cortical hyperintensity in diffusion, fluid attenuate inversion and T2-weighted MRI. We performed serial imaging with single-photon emission computed tomography (SPECT) and MRI in three V180I gCJD cases over long-term observation...
November 15, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27764040/123i-fp-cit-and-99mtc-hmpao-in-pathologically-confirmed-progressive-supranuclear-palsy
#14
Manuela Cristina Matesan, Saeed Elojeimy, Satoshi Minoshima
Molecular brain imaging I-FP-CIT SPECT is an important tool in evaluation of patients with parkinsonism. However, various neurodegenerative etiologies cannot be differentiated by I-FP-CIT SPECT alone. We present a case of progressive supranuclear palsy with abnormal I-FP-CIT SPECT and abnormal Tc-HMPAO SPECT depicted by quantitative analyses but unremarkable MRI 16 months after the onset of symptoms. Brain autopsy demonstrated presence of neuronal and glial tau pathology in both cortical and subcortical regions confirming the diagnosis of progressive supranuclear palsy...
December 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27740992/positron-emission-tomography-and-single-photon-emission-computed-tomography-in-neurology
#15
Robert S Miletich
PURPOSE OF REVIEW: Positron emission tomography (PET) and single-photon emission computed tomography (SPECT) are now available for routine clinical applications in neurology. This article discusses their diagnostic use in dementia, brain tumors, epilepsy, parkinsonism, cerebrovascular disease, and traumatic brain injury. RECENT FINDINGS: Neuromolecular imaging, also known as nuclear neurology, involves clinical imaging of both basal regional physiology (perfusion, metabolism, and transport mechanisms) and specific neurochemical physiology (currently, only the dopamine transporter)...
October 2016: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/27719841/functional-tremor
#16
P Schwingenschuh, G Deuschl
Functional tremor is the commonest reported functional movement disorder. A confident clinical diagnosis of functional tremor is often possible based on the following "positive" criteria: a sudden tremor onset, unusual disease course, often with fluctuations or remissions, distractibility of the tremor if attention is removed from the affected body part, tremor entrainment, tremor variability, and a coactivation sign. Many patients show excessive exhaustion during examination. Other somatizations may be revealed in the medical history and patients may show additional functional neurologic symptoms and signs...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/27697369/heart-rate-variability-in-patients-with-essential-tremor-a-cross-sectional-study
#17
Maria Salsone, Rita Nistico', Basilio Vescio, Fabiana Novellino, Maurizio Morelli, Angela Lupo, Gennarina Arabia, Aldo Quattrone
OBJECTIVE: To investigate heart rate variability (HRV) in patients with Essential Tremor (ET) in comparison with patients with Parkinson's Disease (PD). METHODS: This is a cross sectional control study including 10 patients with ET, 10 patients with PD and 10 age-sex-matched controls. In patients and controls, we measured the components of HRV analysis in the frequency domain during a daytime period of 12-h. Selected HRV variables were low-frequency (LF) and high-frequency (HF), conventionally considered to be influenced by the sympathetic system and the parasympathetic system respectively...
December 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27628070/clinical-heterogeneity-of-lrrk2-p-i2012t-mutation
#18
Tian-Sin Fan, Ruey-Meei Wu, Pei-Lung Chen, Ta-Fu Chen, Huei-Ying Li, Yin-Hung Lin, Chien-Yu Chen, Meng-Ling Chen, Chun-Hwei Tai, Hang-I Lin, Chin-Hsien Lin
INTRODUCTION: Leucine-rich repeat kinase 2 (LRRK2) mutations are the most common genetic cause of Parkinson's disease (PD). However, only few cases carrying LRRK2 mutations have been reported in Taiwanese PD patients. METHODS: We used targeted next generation sequencing (NGS), covering 24 candidate genes involved in neurodegenerative disorders, to analyze 40 probands with familial PD, and 10 patients with mixed neurodegenerative disorders. Sanger sequencing of the identified mutation in the first set of the study was performed in additional 270 PD patients, including 139 familial PD and 131 early-onset PD (onset age less than 50 years old), and 300 age/gender matched control subjects...
December 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27614874/clinical-impact-of-123i-ioflupane-spect-datscan-in-a-movement-disorder-center
#19
Allison K Graebner, Daniel Tarsy, Ludy C Shih, Veronique Vanderhorst, Omesh Kulkarni, Scott Kaplan, David K Simon
BACKGROUND/AIMS: The clinical diagnosis of degenerative forms of parkinsonism is imperfect, with past studies reporting a high rate of misdiagnosis by neurologists and movement disorder specialists, particularly early in the disease course. 123I-ioflupane SPECT (DaTscan) is a diagnostic neuroimaging tool used to distinguish essential tremor from tremor due to degenerative parkinsonisms. The present study expands upon prior studies of the clinical impact of DaTscan imaging in movement disorder centers by assessing quantitative estimates of diagnostic certainty, the impact on subsequent clinical decisions, and the degree to which the asymmetry in the results corresponds to laterality by clinical history and examination...
September 10, 2016: Neuro-degenerative Diseases
https://www.readbyqxmd.com/read/27597825/neuromelanin-imaging-and-dopaminergic-loss-in-parkinson-s-disease
#20
Ioannis U Isaias, Paula Trujillo, Paul Summers, Giorgio Marotta, Luca Mainardi, Gianni Pezzoli, Luigi Zecca, Antonella Costa
Parkinson's disease (PD) is a progressive neurodegenerative disorder in which the major pathologic substrate is a loss of dopaminergic neurons from the substantia nigra. Our main objective was to determine the correspondence between changes in the substantia nigra, evident in neuromelanin and iron sensitive magnetic resonance imaging (MRI), and dopaminergic striatal innervation loss in patients with PD. Eighteen patients and 18 healthy control subjects were included in the study. Using neuromelanin-MRI, we measured the volume of the substantia nigra and the contrast-to-noise-ratio between substantia nigra and a background region...
2016: Frontiers in Aging Neuroscience
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