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https://www.readbyqxmd.com/read/28544831/aortic-root-surgery-in-marfan-syndrome-medium-term-outcome-in-a-single-center-experience
#1
Christine H Attenhofer Jost, Heidi M Connolly, Christopher G Scott, Naser M Ammash, Juan M Bowen, Hartzell V Schaff
BACKGROUND: The study aim was to analyze the authors' experience with aortic root surgery in Marfan syndrome (MFS), and to expand the surgical outcome data of patients meeting the Ghent criteria (Marfan registry). METHODS: Analyses were performed of data acquired from MFS patients (who met the Ghent criteria), including an aortic root surgery and Kaplan-Meier survival. RESULTS: Between April 2004 and February 2012, a total of 59 MFS patients (mean age at surgery 36 ± 13 years) underwent 67 operations for aortic root aneurysm (n = 52), aortic valve (AV) regurgitation (n = 15), acute aortic dissection (n = 2), and/or mitral valve (MV) regurgitation resulting from MV prolapse (n = 7)...
January 2017: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/28544600/effect-of-magnesium-on-arrhythmia-incidence-in-patients-undergoing-coronary-artery-bypass-grafting
#2
Alireza Mohammadzadeh, Farshad Towfighi, Naser Jafari
BACKGROUND: Cardiac arrhythmia after coronary artery bypass grafting (CABG) surgery is a common complication of cardiac surgery. The effect of serum magnesium, hypomagnesaemia treatment and prophylactic administration of magnesium in the development and prevention of arrhythmias is controversial and there are many different ideas. This study evaluates the therapeutic effects of magnesium in cardiac arrhythmia after CABG surgery. METHODS: The clinical trial enrolled 250 patients who underwent CABG...
May 22, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28544242/percutaneous-thoracic-aortic-aneurysm-repair-through-transcaval-aortic-access
#3
Zaher Fanari, Sumaya Hammami, Nilesh J Goswami, Jeffrey A Goldstein
Transcaval aortic access has been used for deployment of transcatheter aortic valves in patients in whom conventional arterial approaches are not feasible. This access can be vital in other situation when large bore access is needed. We described a case of 65-year-old man who had large thoracic descending aortic aneurysm with diffuse bilateral iliac disease precluding the arterial access required for the procedure. The patient underwent successful transcaval access with placement of 22-Fr balloon expandable sheath followed with successful deployments of 32 mm × 32 mm × 150 mm Valiant stent graft (Medtronic, Minneapolis, MN)...
May 22, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28542429/the-unsuitability-of-implantable-doppler-probes-for-the-early-detection-of-renal-vascular-complications-a-porcine-model-for-prevention-of-renal-transplant-loss
#4
Chris Amdisen, Bente Jespersen, Ulla Møldrup, Anna K Keller
BACKGROUND: Vascular occlusion is a rare, but serious complication after kidney transplantation often resulting in graft loss. We therefore aimed to develop an experimental porcine model for stepwise reduction of the renal venous blood flow and to compare an implantable Doppler probe and microdialysis for fast detection of vascular occlusion. METHODS: In 20 pigs, implantable Doppler probes were placed on the renal artery and vein and a microdialysis catheter was placed in the renal cortex...
2017: PloS One
https://www.readbyqxmd.com/read/28542133/protein-disulfide-isomerase-mediated-apoptosis-and-proliferation-of-vascular-smooth-muscle-cells-induced-by-mechanical-stress-and-advanced-glycosylation-end-products-result-in-diabetic-mouse-vein-graft-atherosclerosis
#5
Suning Ping, Shuying Liu, Yuhuan Zhou, Ziqing Li, Yuhuang Li, Kefeng Liu, Adham Sa Bardeesi, Linli Wang, Jingbo Chen, Lie Deng, Jingjing Wang, Hong Wang, Dadi Chen, Zhengyu Zhang, Puyi Sheng, Chaohong Li
Protein disulfide isomerase (PDI) involves cell survival and death. Whether PDI mediates mechanical stretch stress (SS) and/or advanced glycosylation end products (AGEs) -triggered simultaneous increases in proliferation and apoptosis of vascular smooth muscle cells (VSMCs) is unknown. Here, we hypothesized that different expression levels of PDI trigger completely opposite cell fates among the different VSMC subtypes. Mouse veins were grafted into carotid arteries of non-diabetic and diabetic mice for 8 weeks; the grafted veins underwent simultaneous increases in proliferation and apoptosis, which triggered vein graft arterializations in non-diabetic or atherosclerosis in diabetic mice...
May 25, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28542076/comparative-analysis-of-perioperative-and-mid-term-results-of-tecab-and-midcab-for-revascularization-of-anterior-wall
#6
Markus Kofler, Thomas Schachner, Sebastian J Reinstadler, Lukas Stastny, Julia Dumfarth, Dominik Wiedemann, Gudrun Feuchtner, Guy Friedrich, Johannes Bonatti, Nikolaos Bonaros
OBJECTIVE: Totally endoscopic coronary artery bypass (TECAB) and minimally invasive direct coronary artery bypass (MIDCAB) grafting through minithoracotomy are currently the two minimally invasive surgical techniques of left ventricular anterior wall revascularization. We aimed to compare both techniques in terms of perioperative and mid-term results. METHODS: Arrested heart TECAB was carried out in 204 patients with a median (range) age of 60 (53-76) years and a median (range) EuroSCORE I of 2 (0-3)...
May 24, 2017: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
https://www.readbyqxmd.com/read/28541541/intraoperative-chlorpromazine-treatment-for-prevention-of-radial-artery-spasm-in-aortocoronary-bypass-grafting
#7
Vladimir Shipulin, Boris Kozlov, Georgiy Nasrashvili, Vasiliy Zatolokin, Mikhael Kuznetsov, Dmitry Panfilov, Sergey Afanas'ev
A detailed description of intraoperative prevention of radial artery graft spasm using a solution of the calmodulin inhibitor chlorpromazine is presented. This method is used in direct myocardial revascularization and can reliably prevent perioperative spasm of radial artery grafts, as confirmed by intraoperative flow measurement, bypass angiography in the postoperative period, and in vitro experimental data.
May 25, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28540725/a-bio-inspired-3d-multilayered-shape-memory-scaffold-with-a-hierarchically-changeable-micropatterned-surface-for-efficient-vascularization
#8
Dian Liu, Tao Xiang, Tao Gong, Tian Tian, Xian Liu, Shaobing Zhou
How to achieve three-dimensional (3D) cell alignment and subsequent prompt tissue regeneration remains a great challenge. Here, inspired by the interior 3D architecture of native arteries, we develop a new 3D multilayered shape memory vascular scaffold with a hierarchically changeable micropatterned surface for vascularization. The shape memory function renders the implantation of the scaffold safe and convenient via minimally invasive surgery. By co-culturing endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) on the 3D multilayered structure, the inner monolayer, which has a square micropatterned surface, can promote EC adhesion and migration, resulting in rapid endothelialization; the outer multilayers, which have rectangular micropatterned surfaces, can induce a circumferential alignment of VSMCs...
May 25, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28540322/targeting-wnt-%C3%AE-catenin-activated-cells-with-dominant-negative-n-cadherin-to-reduce-neointima-formation
#9
Sarah Hulin-Curtis, Helen Williams, Kerry S Wadey, Graciela B Sala-Newby, Sarah J George
Approximately 50% of coronary artery bypass grafts using the autologous saphenous vein fail within 10 years due to intimal thickening. This study examined whether a gene therapy approach that selectively kills Wnt/β-catenin/T cell factor (TCF) activated vascular smooth muscle cells (VSMCs) using dominant-negative N-cadherin (dn-N-cadherin) reduced intimal thickening. Cultured human VSMCs infected with an adenovirus (Ad) encoding dn-N-cadherin via the TCF promoter (Ad-TOP-dn-N-cadherin) specifically expressed dn-N-cadherin in response to activation of the Wnt/β-catenin/TCF pathway...
June 16, 2017: Molecular Therapy. Methods & Clinical Development
https://www.readbyqxmd.com/read/28540143/association-between-coronary-artery-disease-and-microrna-literature-review-and-clinical-perspective
#10
Rehan Malik, Raja S Mushtaque, Usman A Siddiqui, Adnan Younus, Muhammad A Aziz, Choudhry Humayun, Kanaan Mansoor, Muhammad A Latif, Salman Waheed, Salman Assad, Idrees Khan, Syed M Bukhari, Daniel DelCampo, Ali Adus, Swetha Gannarapu
BACKGROUND: Until recently, circulating micro-RNAs (miRNAs) have attracted major interest as novel biomarkers for the early diagnosis of coronary artery disease (CAD). This review article summarizes the available evidence on the correlation of micro-RNAs with both the clinical and subclinical coronary artery disease and highlights the necessity for exploring miRNAs as a potential diagnostic and prognostic biomarker of early CAD in an adult population. METHODS: A systematic literature analysis and retrieval online systems Public/Publisher MEDLINE/ Excerpta Medica Database /Medical Literature Analysis and Retrieval System Online,(PUBMED/EMBASE/MEDLINE) search were conducted for relevant information...
April 23, 2017: Curēus
https://www.readbyqxmd.com/read/28540076/techniques-for-intraoperative-graft-assessment-in-coronary-artery-bypass-surgery
#11
REVIEW
Lucas B Ohmes, Antonino Di Franco, Gabriele Di Giammarco, Carlo Maria Rosati, Christopher Lau, Leonard N Girardi, Massimo Massetti, Mario Gaudino
Early graft patency is a major determinant of morbidity and mortality following coronary artery bypass surgery. Long-term graft failure is caused by intimal hyperplasia and atherosclerosis, while early failure, especially in the first year, has been attributed, in part, to surgical error. The need for intraoperative graft evaluation is paramount to determine need for revision and ensure future functioning grafts. Transit time flowmetry (TTFM) is the most commonly used intraoperative modality, however, only about 20% of cardiac surgeons in North America use TTFM...
April 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28540075/fractional-flow-reserve-to-guide-surgical-coronary-revascularization
#12
REVIEW
Tara Shah, Joshua D Geleris, Ming Zhong, Rajesh V Swaminathan, Luke K Kim, Dmitriy N Feldman
Coronary angiography has traditionally been used as the final diagnostic tool in the evaluation of coronary artery disease (CAD). However, conventional angiography identifies anatomically obstructive coronary disease, but it is limited in its ability to identify hemodynamically significant lesions. The emergence of fractional flow reserve (FFR) technology, in conjunction with angiography, offers a functional, as well as anatomic, assessment of epicardial coronary obstructions. Several pivotal studies have demonstrated that FFR-guided coronary revascularization is a safe and effective in patients with single and multivessel CAD...
April 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28540071/ct-angio-for-the-evaluation-of-graft-patency
#13
REVIEW
Davide Di Lazzaro, Federico Crusco
Invasive coronary angiography (ICA) is the traditional method for the follow-up of graft patency in coronary artery bypass graft (CABG) patients. Nevertheless, the advent of multidetector computed tomography (MDCT) opened new perspectives for using a noninvasive, equally reliable method to study CABG patients. This review article will analyze the current feasibility of modern multi-slice MDCT, as well as its future perspectives.
April 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28539296/-establishment-of-a-rabbit-model-of-small-diameter-vascular-graft-replacement
#14
Jia-Qing Zhang, Kun-Tang Chen, Fu-Wei Zhang, Shao-Bin Li, Yuan-Zhou Wu, Jing Feng, Wu-Jun Wang, Yu-Sheng Yan
OBJECTIVE: To establish an rabbit model that mimics the hemodynamics of the bypass graft after coronary artery bypass surgery. METHODS: Sixteen New Zealand rabbits were randomly divided into two groups for abdominal aortic artery replacement using a 3-cm-long ePTFE graft with an inner diameter 4 mm through an incision at 1/3 from the middle to the lower part of the abdomen (group A) or in the lower abdomen (group B). The general conditions of the rabbits, operative time, number of collateral vessels that needed to be ligated, rate of massive intraoperative bleeding, fluctuation of vascular anastomosis after surgery, patency rate of the graft on day 7 after the operation were compared between the two groups...
May 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28539044/the-effect-of-resveratrol-on-modulation-of-endothelial-cells-and-macrophages-for-rapid-vascular-regeneration-from-electrospun-poly-%C3%AE%C2%B5-caprolactone-scaffolds
#15
Zhihong Wang, Yifan Wu, Jianing Wang, Chuangnian Zhang, Hongyu Yan, Meifeng Zhu, Kai Wang, Chen Li, Qingbo Xu, Deling Kong
Rapid endothelialization is one key factor that determines the success of small diameter vascular grafts as an artery substitute in the treatment of cardiovascular disease. Aimed to facilitate vascular regeneration, we developed a vascular scaffold loaded with resveratrol, which is a natural compound extracted from plants and showed multifaceted effects in cardiovascular protection. The tubular poly (ε-caprolactone) (PCL) scaffold was prepared by electrospinning with resveratrol in the PCL solution. In vitro assay demonstrated that resveratrol could be released from the scaffolds in a sustained and controlled manner...
May 25, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28538759/comparison-of-two-central-venous-pressure-control-strategies-to-prevent-atrial-fibrillation-after-coronary-artery-bypass-grafting
#16
Mario Augusto Cray da Costa, Wesley Lirani, Ana Caroline Wippich, Luana Lopes, Eduardo de Souza Tolentino, Beatriz Zampar, Marcelo Derbli Schafranski
Background: Atrial fibrillation (AF) takes place in 10-40% of patients undergoing coronary artery bypass grafting (CABG), and increases cardiovascular mortality. Enlargement of atrial chambers is associated with increased AF incidence, so patients with higher central venous pressure (CVP) are expected to have larger atrial distension, which increases AF incidence. Objective: To compare post-CABG AF incidence, following two CVP control strategies. Methods: Interventional, randomized, controlled clinical study...
April 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28538566/predicting-thrombosis-formation-in-1-mm-diameter-arterial-anastomoses-with-transit-time-ultrasound-technology
#17
Gabrielle Shaughness, Collin Blackburn, Alberto Ballestín, Yelena Akelina, Jeffrey A Ascherman
BACKGROUND: Thrombosis is a common source of failure in anastomoses, flaps, and vascular grafts. Ensuring vessel patency is critical to the success of microvascular procedures. Any tool that can accurately predict the patency of an anastomosis intraoperatively would enable the surgeon to detect and correct flow restrictions while the patient is still in the operating room. METHODS: The authors used transit-time ultrasound technology in this pilot study to investigate whether a minimal cutoff value for quantitative postoperative blood flow (in milliliters per minute) could be established that would reliably predict sustained vessel patency at 24 hours postoperatively...
June 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28537454/transfusion-requirements-in-elective-cardiopulmonary-bypass-surgery-patients-predictive-value-of-multiplate-and-thromboelastography-teg-platelet-mapping-assay
#18
Praleene Sivapalan, Anne Caroline Bäck, Sisse Rye Ostrowski, Hanne Berg Ravn, Pär Ingemar Johansson
Managing haemostasis in patients undergoing cardiopulmonary bypass (CPB) surgery remains a challenge. There is no established laboratory test to predict transfusion requirements in cardiac surgery. We investigated whether preoperative Thromboelastography (TEG) with Platelet Mapping Assay (PMA) or Multiple Electrode Aggrometry (MEA) could predict transfusion requirements in patients undergoing elective coronary artery bypass grafting (CABG) or combined CABG with aortic or mitral valve replacement. We prospectively investigated 199 patients undergoing elective CABG or combined procedures...
May 24, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/28537446/clinical-outcomes-of-hypogastric-artery-occlusion-for-endovascular-aortic-aneurysm-repair
#19
Wuttichai Saengprakai, Joost A van Herwaarden, George S Georgiadis, Worawong Slisatkorn, Frans L Moll
PURPOSE: To determine the midterm outcomes of internal iliac artery (IIA) coverage by a stent-graft in endovascular aortic aneurysm repair (EVAR) under specific anatomic and technical circumstances. MATERIAL AND METHODS: From January 2003 until January 2014, 57 patients with aortoiliac aneurysms, including 20 with 24 IIA aneurysms (IIAAs), underwent EVAR with IIA coverage. IIAA diameter change or IIA thrombosis, buttock claudication, type II endoleak, and secondary interventions related to the IIA were studied...
May 24, 2017: Minimally Invasive Therapy & Allied Technologies: MITAT
https://www.readbyqxmd.com/read/28537419/repair-of-a-submitral-aneurysm-with-associated-left-atrial-wall-dissection
#20
Deep Chandh Raja, Vijayanand Palanisamy, Kumar Chidambaram, Ulhas Pandurangi, Ajit Sankardas Mullasari, Rajan Sethuratnam
We describe a case of submitral aneurysm in a 40-year-old man, which was distinctive in its anatomy and pathophysiology. The patient had a congenital submitral aneurysm located in the anterolateral part of the mitral annulus, complicated by dissection of the left atrial wall, severe mitral regurgitation, and compression of the left circumflex artery. He was managed successfully with aid of a comprehensive preoperative evaluation with all available imaging guidance and methodical surgical techniques, resulting in exclusion of the aneurysm, mitral valve replacement, and a graft to the left circumflex artery...
January 1, 2017: Asian Cardiovascular & Thoracic Annals
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