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https://www.readbyqxmd.com/read/29143180/oxidative-stress-in-adult-growth-hormone-deficiency-different-plasma-antioxidant-patterns-in-comparison-with-metabolic-syndrome
#1
Antonio Mancini, Chantal Di Segni, Carmine Bruno, Giulio Olivieri, Francesco Guidi, Andrea Silvestrini, Elisabetta Meucci, Patrick Orlando, Sonia Silvestri, Luca Tiano, Alfredo Pontecorvi
BACKGROUND AND AIMS: Growth hormone deficiency (GHD) is a condition associated with increased cardiovascular risk and insulin-resistance. Oxidative stress (OS) could be a mechanism underlying both these phenomena. In order to investigate plasma antioxidant defenses in such condition, we evaluated adults with GHD, compared with controls and metabolic syndrome patients (MetS), studying plasma total antioxidant capacity (TAC) and coenzyme Q10 (CoQ10, lipophilic antioxidant) levels, both in its oxidized and reduced forms, correlating this data with metabolic and hormonal pattern...
November 15, 2017: Endocrine
https://www.readbyqxmd.com/read/29136343/pharmacokinetics-pharmacodynamics-and-safety-of-a-long-acting-human-growth-hormone-mod-4023-in-healthy-japanese-and-caucasian-adults
#2
William G Kramer, Michal Jaron-Mendelson, Ronit Koren, Oren Hershkovitz, Gili Hart
Daily injections of growth hormone (GH) as replacement therapy in GH-deficient (GHD) patients may cause poor compliance and inconvenience. C-terminal peptide-modified human GH (MOD-4023) has been developed for once-weekly administration in GHD adults and children. In the present study, the pharmacokinetics (PK) and pharmacodynamics (PD) of a single subcutaneous dose of MOD-4023 were evaluated in healthy Caucasian and Japanese adults, using a phase 1 double-blind, vehicle-controlled, randomized study design...
November 14, 2017: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/29127766/etiologies-of-short-stature-in-a-pediatric-endocrine-clinic-in-southern-thailand
#3
Tansit Saengkaew, Edward McNeil, Somchit Jaruratanasirikul
BACKGROUND: Short stature is one of the common disorders referred for investigation of an endocrine disorder. The etiologies of short stature vary and are commonly grouped into pathological and non-pathological disorders. The objective of the study was to determine the etiologies and describe the characteristics of short stature patients who attended the Pediatric Endocrinology Clinic and to compare factors between normal variant short stature (NVSS) and growth hormone deficiency (GHD)...
November 11, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29127748/-issues-related-to-secondary-osteoporosis-associated-with-growth-hormone-deficiency-in-adulthood
#4
Martin Kužma, Peter Jackuliak, Zdenko Killinger, Peter Vaňuga, Juraj Payer
Growth hormone (GH) increases linear bone growth through complex hormonal reactions, mainly mediated by insulin like growth factor 1 (IGF1) that is produced mostly by hepatocytes under influence of GH and stimulates differentiation of epiphyseal prechondrocytes. IGF1 and GH play a key role in the linear bone growth after birth and regulation of bone remodelation during the entire lifespan. It is known that adult GH deficient (GHD) patients have decreased BMD and increased risk of low-impact fractures. Most data gathered thus far on the effect of GH replacement on bone status comprise the measurement of quantitative changes of bone mass...
2017: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29127617/effects-of-growth-hormone-treatment-on-lipid-profiles
#5
Toshihide Kubo, Mahoko Furujo, Kyohei Takahashi, Yuki Hyodo, Hiroki Tsuchiya, Mariko Hattori, Shoko Fujinaga, Kenji Urayama
OBJECTIVES: To assess the effects of growth hormone (GH) on lipid profiles in children and whether the effect is pharmacological. METHODS: The authors determined serum levels of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), non-high-density lipoprotein cholesterol (non-HDL-C), and low-density lipoprotein cholesterol (LDL-C) every year during 3-y GH treatment in 48 GH deficient (GHD) short children and 22 children with short stature born small for gestational age (SGA)...
November 11, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29107171/progression-from-isolated-growth-hormone-deficiency-to-combined-pituitary-hormone-deficiency
#6
REVIEW
Manuela Cerbone, Mehul T Dattani
Growth hormone deficiency (GHD) can present at any time of life from the neonatal period to adulthood, as a result of congenital or acquired insults. It can present as an isolated problem (IGHD) or in combination with other pituitary hormone deficiencies (CPHD). Pituitary deficits can evolve at any time from GHD diagnosis. The number, severity and timing of occurrence of additional endocrinopathies are highly variable. The risk of progression from IGHD to CPHD in children varies depending on the etiology (idiopathic vs organic)...
October 19, 2017: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/29098662/deregulation-of-the-growth-hormone-insulin-like-growth-factor-1-axis-in-adults-with-cystic-fibrosis
#7
C Pascucci, R V De Biase, D Savi, S Quattrucci, A M Isidori, C Lubrano, L Gnessi, A Lenzi
PURPOSE: Patients with cystic fibrosis (CF) present with signs and symptoms that overlap with those of adult growth hormone deficiency (GHD) syndrome: loss of muscle mass, bone fragility and lower stress tolerance. In literature, the prevalence of GHD in pediatric CF patients is higher than general population, but these studies have been performed on children with growth delay. To our knowledge, there are no studies on adult patients. The aim of this paper is to evaluate GH-IGF1 axis in an adult CF population...
November 2, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29082892/retinal-neural-and-vascular-structure-in-isolated-growth-hormone-deficiency-children-and-evaluation-of-growth-hormone-treatment-effect-on-retina
#8
Özge Yüce, Nuriye Gökçen Yalçın, Aysun Bideci, Esra Döğer, Hamdi Cihan Emeksiz, Murat Hasanreisoğlu, Zeynep Aktaş, Orhun Çamurdan, Peyami Cinaz
OBJECTIVE: Our aim was to evaluate neural and vascular retinal morphology of children with isolated growth hormone deficiency (GHD) and to determine any retinal changes of GH treatment. METHODS: Twenty-eight children with isolated GHD and 53 age-, gender- and body mass index-matched healthy volunteers were enrolled in this prospective study. The retinal nerve fibre layer(RNFL), macular thickness(MT) were measured, as well as intraocular pressure(IOP) . The number of retinal vascular branching points were calculated...
October 30, 2017: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/29070768/effect-of-growth-hormone-replacement-therapy-on-plasma-diacron-reactive-oxygen-metabolites-and-endothelial-function-in-japanese-patients-the-great-clinical-study
#9
Kunihiro Suzuki, Kazunori Yanagi, Masanori Shimizu, Sho Wakamatsu, Takafumi Niitani, Soichiro Hosonuma, Masaaki Sagara, Yoshimasa Aso
Patients with growth hormone deficiency (GHD) have an increased risk of atherosclerosis and vascular mortality. Evidence suggests that endothelial dysfunction is involved in all stages of atherogenesis. This study examined the effect of growth hormone (GH) replacement therapy on diacron-reactive oxygen metabolites (d-ROMs) and endothelial function in Japanese patients with GHD, using peripheral arterial tonometry. This was an open-label, prospective, case-control study. Nine patients with GHD who had not previously received any GH replacement therapy were enrolled...
October 25, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/29048743/menopause-is-associated-with-impaired-responsiveness-of-involuntary-pelvic-floor-muscle-contractions-to-sudden-intra-abdominal-pressure-rise-in-women-with-pelvic-floor-symptoms-a-retrospective-study
#10
Wen-Chen Huang, Jenn-Ming Yang
AIMS: To explore the effect of menopause on the movements of the bladder neck and genital hiatus during involuntary and voluntary pelvic floor muscle (PFM) contractions among women with pelvic floor symptoms. METHODS: The data of 162 premenopausal and 215 postmenopausal women were retrospectively analyzed. The investigation encompassed clinical interview, pelvic examination, and four-dimensional ultrasound. The ultrasound manifestations of the bladder neck and genital hiatus during involuntary and voluntary PFM contractions were assessed during coughing and maximal squeezing...
October 19, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29033135/one-year-recombinant-growth-hormone-therapy-does-not-improve-hemoglobin-state-and-morphology-of-erythrocytes-in-growth-hormone-deficient-children
#11
Maria Pankratova, Alexander Yusipovich, Maria Vorontsova, Evgenia Parshina, Svetlana Bochkareva, Alexander Cherkashin, Adil Baizhumanov, Margarita Silicheva, Tatyana Shiryaeva, Georgy Maksimov, Valentina Peterkova
An increase in growth rates of children suffering from growth hormone deficiency (GHD) subjected to recombinant growth hormone treatment (rGHT) was shown to be accompanied by acceleration of metabolic processes that may stimulate oxygen consumption in various organs and tissues. Therefore, oxygen-transporting properties of RBC should undergo considerable changes during the rGHT. The aim of this study was to examine the effects of rGHT on erythrocyte shape and hemoglobin state in GHD children. The level of oxyhemoglobin (Oxy-Hb) in RBC was analyzed by Raman spectroscopy...
October 7, 2017: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/29030774/effects-of-growth-hormone-therapy-on-bone-density-and-fracture-risk-in-age-related-osteoporosis-in-the-absence-of-growth-hormone-deficiency-a-systematic-review-and-meta-analysis
#12
Maya Barake, Asma Arabi, Nancy Nakhoul, Ghada El-Hajj Fuleihan, Sarah El Ghandour, Anne Klibanski, Nicholas A Tritos
PURPOSE: In adults, growth hormone deficiency (GHD) has been associated with low bone mineral density (BMD), an effect counteracted by growth hormone (GH) replacement. Whether GH is beneficial in adults with age-related bone loss and without hypopituitarism is unclear. METHODS: We conducted a systematic literature search using Medline, Embase and the Cochrane Register of Controlled Trials. We extracted and analyzed data according to the bone outcome included [bone mineral content (BMC), BMD, and bone biomarker, fracture risk]...
October 13, 2017: Endocrine
https://www.readbyqxmd.com/read/28984555/paracoccus-litorisediminis-sp-nov-isolated-from-a-tidal-flat
#13
Sooyeon Park, Jeehyun Choi, Su Jung Choi, Jung-Hoon Yoon
A Gram-stain-negative, non-spore-forming, non-motile and coccoid, ovoid or short rod-shaped bacterial strain, designated GHD-05(T), was isolated from a tidal flat on the Yellow Sea in South Korea. Strain GHD-05(T) grew optimally at 30 °C, at pH 7.0-8.0 and in the presence of 2.0 % (w/v) NaCl. The phylogenetic trees based on 16S rRNA gene sequences showed that strain GHD-05(T) belonged to the genus Paracoccus, clustering with the type strain of Paracoccusaestuariivivens. Strain GHD-05(T) exhibited 16S rRNA gene sequence similarity values of 97...
October 6, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28947559/the-rationale-and-design-of-transcon-growth-hormone-for-the-treatment-of-growth-hormone-deficiency
#14
REVIEW
Kennett Sprogøe, Eva Mortensen, David B Karpf, Jonathan A Leff
The fundamental challenge of developing a long-acting growth hormone (LAGH) is to create a more convenient growth hormone (GH) dosing profile while retaining the excellent safety, efficacy and tolerability of daily GH. With GH receptors on virtually all cells, replacement therapy should achieve the same tissue distribution and effects of daily (and endogenous) GH while maintaining levels of GH and resulting IGF-1 within the physiologic range. To date, only two LAGHs have gained the approval of either the Food and Drug Administration (FDA) or the European Medicines Agency (EMA); both released unmodified GH, thus presumably replicating distribution and pharmacological actions of daily GH...
November 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28938456/growth-hormone-improves-cardiopulmonary-capacity-and-body-composition-in-children-with-growth-hormone-deficiency
#15
Donatella Capalbo, Flavia Barbieri, Nicola Improda, Francesco Giallauria, Elisa Di Pietro, Antonio Rapacciuolo, Raffaella Di Mase, Carlo Vigorito, Mariacarolina Salerno
Context: Growth hormone deficiency (GHD) in children may be associated with early cardiovascular risk factors and alterations in left ventricular (LV) structure and function; data on cardiopulmonary functional capacity are lacking. Objectives: Aim of the study was to evaluate the effect of GHD and growth hormone (GH) therapy on cardiopulmonary functional capacity, left and right cardiac structure and function, and body composition in children and adolescents. Design: Prospective, case-control study...
November 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28933319/paracoccus-sordidisoli-sp-nov-isolated-from-an-agricultural-field-contaminated-with-hexachlorocyclohexane-isomers
#16
Amit Kumar Singh, Puneet Kohli, Nitish Kumar Mahato, Rup Lal
A novel bacterial strain, designated LP91T, was isolated from an agricultural field contaminated with hexachlorocyclohexane (HCH) isomers at Ummari Village, Lucknow, Uttar Pradesh, India. Cells of the strain were aerobic, short rod or coccoid, Gram-stain-negative and non-motile. Colonies of the strain were initially transparent but with time changed to a creamy white colour. Phylogenetic analysis based on the 16S rRNA marker gene showed that it was closely associated with Paracoccus aestuariivivens GHD-30T (99...
September 21, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28926833/circulating-igf-i-igfbp-3-and-the-igf-i-igfbp-3-molar-ratio-concentration-and-height-outcome-in-prepubertal-short-children-on-rhgh-treatment-over-two-years-of-therapy
#17
María Gabriela Ballerini, Débora Braslavsky, Paula Alejandra Scaglia, Ana Keselman, María Eugenia Rodríguez, Alicia Martínez, Analía Verónica Freire, Horacio Mario Domené, Héctor Guillermo Jasper, Ignacio Bergadá, María Gabriela Ropelato
OBJECTIVE: To investigate the occurrence of abnormally elevated values of biomarkers of growth hormone (GH) action in short children on recombinant human GH (rhGH) therapy. METHODS: Sixty-three prepubertal short children were examined: 31 with GH deficiency (GHD), 25 small for gestational age (SGA), and 9 with Turner syndrome (TS). The main outcomes were the following: standard deviation score (SDS) values of IGF-I, IGFBP-3, and IGF-I/IGFBP-3 molar ratio before, at the 1st and at the 2nd year on rhGH and Δheight (Ht)-SDS to evaluate GH treatment efficacy (adequate 1st-year ΔHt SDS: >0...
September 19, 2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/28925898/gh-supplementation-effects-on-cardiovascular-risk-in-gh-deficient-adult-patients-a-systematic-review-and-meta-analysis
#18
Vito Angelo Giagulli, Marco Castellana, Raffaella Perrone, Edoardo Guastamacchia, Massimo Iacoviello, Vincenzo Triggiani
BACKGROUND AND OBJECTIVE: The current meta-analysis aims at evaluating whether the existing clinical evidence may ascertain the effects of growth hormone (GH) replacement therapy on cardiovascular risk, both in isolated GH deficiency (GHD) and in compensated panhypopituitarism including GH deficit. METHOD: Original articles published from 1991 to 2015 were searched on Medline (Pubmed). Among an overall number of 181 potentially suitable studies, 24 fulfilled the selection criteria and were included in the analysis...
September 19, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/28915901/possible-effects-of-an-early-diagnosis-and-treatment-in-patients-with-growth-hormone-deficiency-the-state-of-art
#19
REVIEW
Stefano Stagi, Perla Scalini, Giovanni Farello, Alberto Verrotti
Growth hormone deficiency (GHD) is a relatively uncommon and heterogeneous endocrine disorder presenting in childhood with short stature. However, during the neonatal period, the metabolic effects of GHD may to require prompt replacement therapy to avoid possible life-threatening complications. An increasing amount of data suggests the importance of an early diagnosis and treatment of GHD because of its auxological, metabolic, and neurodevelopmental features with respect to the patients diagnosed and treated later in life...
September 16, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/28904008/mechanisms-in-endocrinology-clinical-and-pharmacogenetic-aspects-of-the-growth-hormone-receptor-polymorphism
#20
REVIEW
Cesar L Boguszewski, Edna J L Barbosa, Per-Arne Svensson, Gudmundur Johannsson, Camilla A M Glad
Pharmacogenetics aims to maximize the beneficial effects of a medical therapy by identifying genetic finger prints from responders and non-responders and, thereby improving safety and efficacy profile of the drug. Most subjects who are deficient in growth hormone (GHD) are candidates for recombinant human GH (rhGH) therapy. To date, it is well established that even after adjustments for several clinical variables, such as age, gender, body composition and the age at onset of the GHD, response to rhGH treatment is highly variable among individuals, part of which is believed to be due to genetic factors within the GH system...
December 2017: European Journal of Endocrinology
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