keyword
MENU ▼
Read by QxMD icon Read
search

GH deficit

keyword
https://www.readbyqxmd.com/read/27878771/growth-hormone-deficiency-and-hypopituitarism-in-adults-after-complicated-mild-traumatic-brain-injury
#1
Stefania Giuliano, Serafina Talarico, Lucia Bruno, Francesco Beniamino Nicoletti, Claudio Ceccotti, Antonino Belfiore
PURPOSE: Traumatic brain injury is considered the main cause of hypopituitarism in adults, and GH deficiency appears to be the most frequent pituitary deficit. Most of the available studies have included all degrees of severity of trauma. We aimed to assess pituitary function and GH deficiency in adult patients at different time lengths after complicated mild TBI according to Glasgow Coma Scale. We also aimed to evaluate whether mild TBI patients with GH deficiency had developed alterations in the glycolipid profile...
November 23, 2016: Endocrine
https://www.readbyqxmd.com/read/27820671/contribution-of-lhx4-mutations-to-pituitary-deficits-in-a-cohort-of-417-unrelated-patients
#2
Enzo Cohen, Mohamad Maghnie, Nathalie Collot, Juliane Leger, Florence Dastot, Michel Polak, Sophie Rose, Philippe Touraine, Philippe Duquesnoy, Maïté Tauber, Bruno Copin, Anne-Marie Bertrand, Frederic Brioude, Daniela Larizza, Thomas Edouard, Laura González Briceño, Irène Netchine, Isabelle Oliver-Petit, Marie-Laure Sobrier, Serge Amselem, Marie Legendre
CONTEXT: LHX4 encodes a LIM-homeodomain transcription factor implicated in early pituitary development. In humans, only 13 heterozygous LHX4 mutations have been associated with congenital hypopituitarism. OBJECTIVE: To evaluate the prevalence of LHX4 mutations in patients with hypopituitarism, and to precise the associated phenotypes. To characterize the functional impact of the identified variants and the respective role of the two LIM domains of LHX4. PATIENTS AND DESIGN: We screened 417 unrelated patients with isolated growth hormone deficiency or combined pituitary hormone deficiency associated with ectopic posterior pituitary and/or sella turcica anomalies for LHX4 mutations (Sanger sequencing)...
November 7, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27778105/can-early-clinical-parameters-predict-post-traumatic-pituitary-dysfunction-in-severe-traumatic-brain-injury
#3
O Nemes, N Kovacs, Sz Szujo, B Bodis, L Bajnok, A Buki, T Doczi, E Czeiter, E Mezosi
BACKGROUND: Post-traumatic hypopituitarism is a major complication after severe head trauma. The aim of our study was to evaluate the possible role of early clinical parameters in the development of endocrine deficits. METHODS: Data on endocrine function, on-admission clinical-, laboratory-, and ICU-monitored parameters were available in 63 patients of the surviving 86 severe head injury patients (post-resuscitation GCS under 8) treated at one neurosurgical center during a 10-year period...
October 25, 2016: Acta Neurochirurgica
https://www.readbyqxmd.com/read/27712965/systemic-inflammation-growth-factors-and-linear-growth-in-the-setting-of-infection-and-malnutrition
#4
Mark D DeBoer, Rebecca J Scharf, Alvaro M Leite, Alessandra Férrer, Alexandre Havt, Relana Pinkerton, Aldo A Lima, Richard L Guerrant
OBJECTIVES: Deficits in weight gain and linear growth are seen frequently among children in areas where malnutrition and recurrent infections are common. Although both inflammation and malnutrition can result in growth hormone (GH) resistance, the interrelationships of infection, inflammation, and growth deficits in developing areas remain unclear. The aim of this study was to evaluate relationships between low levels of systemic inflammation, growth factors, and anthropometry in a case-control cohort of underweight and normal weight children in northern Brazil...
January 2017: Nutrition
https://www.readbyqxmd.com/read/27668645/growth-hormone-deficiency-in-children-and-young-adults
#5
Joanna Oświęcimska, Wojciech Roczniak, Agata Mikołajczak, Agnieszka Szymlak
Growth hormone (GH) is a naturally occurring polypeptide hormone produced by somatotropic cells in the anterior pituitary. The main function of somatotropin is stimulation of linear growth, but it also affects carbohydrate metabolism, increases bone mass and has potent lipolytic, antinatriuretic and antidiuretic effects. Growth hormone deficiency (GHD) may occur both in children and in adults. At the moment there is no gold standard for the diagnosis of GHD, and the diagnosis should take into account clinical, auxological, biochemical and radiological changes and, if necessary, genetic testing...
2016: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/27635959/congress-of-neurological-surgeons-systematic-review-and-evidence-based-guideline-for-pretreatment-endocrine-evaluation-of-patients-with-nonfunctioning-pituitary-adenomas
#6
Maria Fleseriu, Mary E Bodach, Luis M Tumialan, Vivien Bonert, Nelson M Oyesiku, Chirag G Patil, Zachary Litvack, Manish K Aghi, Gabriel Zada
BACKGROUND: Nonfunctioning pituitary adenomas (NFPAs) are among the most common pituitary lesions and may present with hypopituitarism and/or hyperprolactinemia. OBJECTIVE: To review the existing literature as it pertains to preoperative endocrine assessment in the workup for NFPAs. METHODS: A systematic review methodology was utilized to identify and screen articles assessing the role and results of preoperative laboratory assessment in patients with NFPAs...
October 2016: Neurosurgery
https://www.readbyqxmd.com/read/27582416/effect-of-mesenchymal-stem-cells-and-galantamine-nanoparticles-in-rat-model-of-alzheimer-s-disease
#7
Shubham Misra, Kanwaljit Chopra, Uma Nahar Saikia, Vivek Ranjan Sinha, Rakesh Sehgal, Manish Modi, Bikash Medhi
AIM: The present study investigated the efficacy of bone marrow-derived mesenchymal stem cells (BM-MSCs) in combination with galantamine hydrobromide-loaded solid lipid nanoparticles (GH-SLNs) in intracerebroventricular (ICV)-isoproterenol-induced rat model of Alzheimer's disease. MATERIALS & METHODS: BM-MSCs were harvested by dissecting femur and tibia of 8-10-week-old Wistar rats. 1 × 10(6) cells were administered intravenously once in ICV-isoproterenol-induced rats followed by GH-SLNs (5 mg/kg) for 3 weeks...
October 2016: Regenerative Medicine
https://www.readbyqxmd.com/read/27487097/long-term-outcomes-genetics-and-pituitary-morphology-in-patients-with-isolated-growth-hormone-deficiency-and-multiple-pituitary-hormone-deficiencies-a-single-centre-experience-of-four-decades-of-growth-hormone-replacement
#8
Julia Rohayem, Hendrik Drechsel, Bettina Tittel, Gabriele Hahn, Roland Pfaeffle, Angela Huebner
BACKGROUND: Growth hormone (GH) has been used to treat children with GH deficiency (GHD) since 1966. AIMS: Using a combined retrospective and cross-sectional approach, we explored the long-term outcomes of patients with GHD, analysed factors influencing therapeutic response, determined persistence into adulthood, investigated pituitary morphology, and screened for mutations in causative genes. METHODS: The files of 96 GH-deficient children were reviewed...
2016: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/27476159/long-term-effect-of-cranial-radiotherapy-on-pituitary-hypothalamus-area-in-childhood-acute-lymphoblastic-leukemia-survivors
#9
REVIEW
Cecilia Follin, Eva Marie Erfurth
Survival rates of childhood cancer have improved markedly, and today more than 80 % of those diagnosed with a pediatric malignancy will become 5-year survivors. Nevertheless, survivors exposed to cranial radiotherapy (CRT) are at particularly high risk for long-term morbidity, such as endocrine insufficiencies, metabolic complications, and cardiovascular morbidity. Deficiencies of one or more anterior pituitary hormones have been described following therapeutic CRT for primary brain tumors, nasopharyngeal tumors, and following prophylactic CRT for childhood acute lymphoblastic leukemia (ALL)...
September 2016: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/27472279/circulating-levels-of-irisin-in-hypopituitary-and-normal-subjects
#10
Lara Pena-Bello, Sonia Pértega-Diaz, Susana Sangiao-Alvarellos, Elena Outeiriño-Blanco, Raquel Eiras-Leal, Bárbara Varela-Rodriguez, Paula Juiz-Valiña, Miguel Pérez-Fontán, María Cordido, Fernando Cordido
CONTEXT: The recently identified myokine irisin conveys some of the benefits of exercise. Hypopituitarism with adult growth hormone deficiency (HP) is a situation characterized by decreased GH secretion and an altered body composition. OBJECTIVE: Our aim was to study the skeletal muscle hormone irisin in HP, and compare the results with a similar group of normal subjects. PARTICIPANTS AND METHODS: Seventeen HP patients and fifty-one normal subjects of similar age and sex were studied...
2016: PloS One
https://www.readbyqxmd.com/read/27382048/down-regulation-of-hippocampal-genes-regulating-dopaminergic-gabaergic-and-glutamatergic-function-following-combined-neonatal-phencyclidine-and-post-weaning-social-isolation-of-rats-as-a-neurodevelopmental-model-for-schizophrenia
#11
Philip Lr Gaskin, Maria Toledo-Rodriguez, Stephen Ph Alexander, Kevin Cf Fone
BACKGROUND: Dysfunction of dopaminergic, GABAergic, and glutamatergic function underlies many core symptoms of schizophrenia. Combined neonatal injection of the N-methyl-D-aspartate (NMDA) receptor antagonist, phencyclidine (PCP), and post-weaning social isolation of rats produces a behavioral syndrome with translational relevance to several core symptoms of schizophrenia. This study uses DNA microarray to characterize alterations in hippocampal neurotransmitter-related gene expression and examines the ability of the sodium channel blocker, lamotrigine, to reverse behavioral changes in this model...
November 2016: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27378855/isolation-rearing-reduces-neuronal-excitability-in-dentate-gyrus-granule-cells-of-adolescent-c57bl-6j-mice-role-of-gabaergic-tonic-currents-and-neurosteroids
#12
Giuseppe Talani, Francesca Biggio, Valentina Licheri, Valentina Locci, Giovanni Biggio, Enrico Sanna
Early-life exposure to stress, by impacting on a brain still under development, is considered a critical factor for the increased vulnerability to psychiatric disorders and abuse of psychotropic substances during adulthood. As previously reported, rearing C57BL/6J weanling mice in social isolation (SI) from their peers for several weeks, a model of prolonged stress, is associated with a decreased plasma and brain levels of neuroactive steroids such as 3α,5α-THP, with a parallel up-regulation of extrasynaptic GABAA receptors (GABAAR) in dentate gyrus (DG) granule cells compared to group-housed (GH) mice...
2016: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/27192539/therapeutic-augmentation-of-the-growth-hormone-axis-to-improve-outcomes-following-peripheral-nerve-injury
#13
Sami H Tuffaha, Prateush Singh, Joshua D Budihardjo, Kenneth R Means, James P Higgins, Jaimie T Shores, Roberto Salvatori, Ahmet Höke, W P Andrew Lee, Gerald Brandacher
INTRODUCTION: Peripheral nerve injuries often result in debilitating motor and sensory deficits. There are currently no therapeutic agents that are clinically available to enhance the regenerative process. Following surgical repair, axons often must regenerate long distances to reach and reinnervate distal targets. Progressive atrophy of denervated muscle and Schwann cells (SCs) prior to reinnervation contributes to poor outcomes. Growth hormone (GH)-based therapies have the potential to accelerate axonal regeneration while at the same time limiting atrophy of muscle and the distal regenerative pathway prior to reinnervation...
October 2016: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/27129699/growth-hormone-deficiency-during-young-adulthood-and-the-benefits-of-growth-hormone-replacement
#14
REVIEW
M Ahmid, C G Perry, S F Ahmed, M G Shaikh
Until quite recently, the management of children with growth hormone deficiency (GHD) had focussed on the use of recombinant human GH (rhGH) therapy to normalise final adult height. However, research over the past two decades that has demonstrated deficits in bone health and cardiac function, as well as impaired quality of life in adults with childhood-onset GHD (CO-GHD), has questioned this practice. Some of these studies suggested that there may be short-term benefits of rhGH in certain group of adolescents with GHD during transition, although the impact of GHD and replacement during the transition period has not been adequately investigated and its long-term benefits remain unclear...
May 2016: Endocrine Connections
https://www.readbyqxmd.com/read/27026954/increased-release-of-mercury-from-dental-amalgam-fillings-due-to-maternal-exposure-to-electromagnetic-fields-as-a-possible-mechanism-for-the-high-rates-of-autism-in-the-offspring-introducing-a-hypothesis
#15
Gh Mortazavi, M Haghani, N Rastegarian, S Zarei, S M J Mortazavi
According to the World Health Organization (WHO), factors such as growing electricity demand, ever-advancing technologies and changes in social behaviour have led to steadily increasing exposure to man-made electromagnetic fields.  Dental amalgam fillings are among the major sources of exposure to elemental mercury vapour in the general population. Although it was previously believed that low levels are mercury (i.g. release of mercury from dental amalgam) is not hazardous, now numerous data indicate that even very low doses of mercury cause toxicity...
March 2016: Journal of Biomedical Physics & Engineering
https://www.readbyqxmd.com/read/26936284/growth-and-growth-hormone-an-overview
#16
Enrique Teran, Jaclyn Chesner, Robert Rapaport
Growth is a good indicator of a child's health. Growth disturbances, including short stature or growth failure, could be indications of illnesses such as chronic disease, nutritional deficits, celiac disease or hormonal abnormalities. Therefore, a careful assessment of the various requirements for normal growth needs to be done by history, physical examination, and screening laboratory tests. More details will be reviewed about the GH-IGF axis, its abnormalities with special emphasis on GH deficiency, its diagnosis and treatment...
June 2016: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/26822565/recombinant-igf-i-past-present-and-future
#17
George M Bright
Normal linear growth in humans requires GH and IGF-I. Diminished GH action resulting in reduced availability of IGF-I and IGF-binding proteins is the hallmarks of GH Insensitivity Syndromes (GHIS). The deficiencies are the perceived mechanisms for the growth failure of affected patients and the therapeutic targets for the restoration of normal growth. Early treatment attempts with pituitary-derived GH had limited effects in GHIS patients. Recombinant human insulin-like growth factor-I (rhIGF-I) treatment initially provides accelerated growth to GHIS children and provides substantial benefit...
June 2016: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/26821051/learning-and-memory-recoveries-in-a-young-girl-treated-with-growth-hormone-and-neurorehabilitation
#18
Jesús Devesa, Hortensia Lema, Eva Zas, Borja Munín, Pilar Taboada, Pablo Devesa
Background-To describe the results obtained after treating a non growth hormone-deficient 10-year-old girl who suffered asphyxia during delivery, resulting in important cognitive deficits, with growth hormone (GH) and neurorehabilitation. Methods-GH was administered (mg/day) at doses of 0.5 over three months followed by 0.9, every two weeks over three months, and then alternating 1.2 three days/week and 0.3 two days/week. Neurorehabilitation consisted of daily sessions of neurostimulation, speech therapy, occupational therapy and auditive stimulation...
2016: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/26777041/the-effect-of-recombinant-growth-hormone-treatment-in-children-with-idiopathic-short-stature-and-low-insulin-like-growth-factor-1-levels
#19
Zeynep Şıklar, Pınar Kocaay, Emine Çamtosun, Mehmet İsakoca, Bülent Hacıhamdioğlu, Şenay Savaş Erdeve, Merih Berberoğlu
OBJECTIVE: Idiopathic short stature (ISS) constitutes a heterogeneous group of short stature which is not associated with an endocrine or other identifiable cause. Some ISS patients may have varying degrees of insulin-like growth factor-1 (IGF-1) deficiency. Recombinant growth hormone (rGH) treatment has been used by some authors with variable results. Reports on long-term rGH treatment are limited. METHODS: In this study, 21 slowly growing, non-GH-deficient ISS children who received rGH treatment for 3...
December 2015: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/26744895/x-chromosome-gene-dosage-as-a-determinant-of-impaired-pre-and-postnatal-growth-and-adult-height-in-turner-syndrome
#20
MULTICENTER STUDY
Elodie Fiot, Delphine Zenaty, Priscilla Boizeau, Jeremy Haigneré, Sophie Dos Santos, Juliane Léger
OBJECTIVE: Short stature is a key aspect of the phenotype of patients with Turner syndrome (TS). SHOX haploinsufficiency is responsible for about two-thirds of the height deficit. The aim was to investigate the effect of X-chromosome gene dosage on anthropometric parameters at birth, spontaneous height, and adult height (AH) after growth hormone (GH) treatment. DESIGN: We conducted a national observational multicenter study. METHODS: Birth parameter SDS for gestational age, height, and AH before and after GH treatment respectively, and height deficit with respect to target height (SDS) were classified by karyotype subgroup in a cohort of 1501 patients with TS: 45,X (36%), isoXq (19%), 45,X/46,XX (15%), XrX (7%), presence of Y (6%), or other karyotypes (17%)...
March 2016: European Journal of Endocrinology
keyword
keyword
97222
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"