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Sustained Remission

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https://www.readbyqxmd.com/read/29033936/coinhibitory-receptor-expression-and-immune-checkpoint-blockade-maintaining-a-balance-in-cd8-t-cell-responses-to-chronic-viral-infections-and-cancer
#1
REVIEW
Isobel S Okoye, Michael Houghton, Lorne Tyrrell, Khaled Barakat, Shokrollah Elahi
In cancer and chronic viral infections, T cells are exposed to persistent antigen stimulation. This results in expression of multiple inhibitory receptors also called "immune checkpoints" by T cells. Although these inhibitory receptors under normal conditions maintain self-tolerance and prevent immunopathology, their sustained expression deteriorates T cell function: a phenomenon called exhaustion. Recent advances in cancer immunotherapy involve blockade of cytotoxic T lymphocyte antigen-4 and programmed cell death 1 in order to reverse T cell exhaustion and reinvigorate immunity, which has translated to dramatic clinical remission in many cases of metastatic melanoma and lung cancer...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29033629/electroconvulsive-therapy-in-the-treatment-of-mood-disorders-one-year-follow-up
#2
Sibel Çakir, Nuran Çağlar
INTRODUCTION: Electroconvulsive therapy (ECT) is known to be an effective option in the treatment of mood disorders, especially resistant depression. However, the remission achieved by ECT was reported to be not long lasting enough. The aim of the present study was to investigate the relapse/recurrence rates and associated risk factors during the first year after ECT in patients diagnosed with mood disorders. METHODS: In a naturalistic observation, patients diagnosed with unipolar depressive disorder or a depressive episode of bipolar disorder and who had achieved remission by ECT were followed up for at least one year...
September 2017: Noro Psikiyatri Arsivi
https://www.readbyqxmd.com/read/29032909/subclinical-synovitis-measured-by-ultrasound-in-rheumatoid-arthritis-patients-with-clinical-remission-induced-by-synthetic-and-biological-modifying-disease-drugs
#3
Marcos Cruces, Soham Al Snih, Natalí Serra-Bonett, Juan C Rivas
BACKGROUND: Rheumatoid arthritis (RA) patients with disease in clinical remission might show subclinical synovitis, which can be related to the progress of structural joint damage. OBJECTIVE: To determine and compare the degree of synovial inflammation by ultrasound (US) in patients with RA in clinical remission, treated with DMARD or combination therapy with DMARD and anti-TNF. METHODS: Hospital-based cross-sectional study of 58 patients with RA in sustained remission for at least 6 months by DAS28 <2...
October 9, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/29030662/oral-histone-deacetylase-inhibitor-synergises-with-t-cell-targeted-immunotherapy-to-preserve-beta-cell-metabolic-function-and-induce-stable-remission-of-new-onset-autoimmune-diabetes-in-nod-mice
#4
Alix Besançon, Tania Goncalves, Fabrice Valette, Mattias S Dahllöf, Thomas Mandrup-Poulsen, Lucienne Chatenoud, Sylvaine You
AIM/HYPOTHESIS: Combination therapy targeting the major actors involved in the immune-mediated destruction of pancreatic beta cells appears to be an indispensable approach to treat type 1 diabetes effectively. We hypothesised that the combination of an orally active pan-histone deacetylase inhibitor (HDACi: givinostat) with subtherapeutic doses of CD3 antibodies may provide ideal synergy to treat ongoing autoimmunity. METHODS: NOD mice transgenic for the human CD3ε (also known as CD3E) chain (NOD-huCD3ε) were treated for recent-onset diabetes with oral givinostat, subtherapeutic doses of humanised CD3 antibodies (otelixizumab, 50 μg/day, 5 days, i...
October 13, 2017: Diabetologia
https://www.readbyqxmd.com/read/29026923/nonhuman-primate-models-for-studies-of-aids-virus-persistence-during-suppressive-combination-antiretroviral-therapy
#5
Gregory Q Del Prete, Jeffrey D Lifson
Nonhuman primate (NHP) models of AIDS represent a potentially powerful component of the effort to understand in vivo sources of AIDS virus that persist in the setting of suppressive combination antiretroviral therapy (cART) and to develop and evaluate novel strategies for more definitive treatment of HIV infection (i.e., viral eradication "cure", or sustained off-cART remission). Multiple different NHP models are available, each characterized by a particular NHP species, infecting virus, and cART regimen, and each with a distinct capacity to recapitulate different aspects of HIV infection...
October 13, 2017: Current Topics in Microbiology and Immunology
https://www.readbyqxmd.com/read/29021478/rhabdomyolysis-in-a-patient-with-polyarteritis-nodosa
#6
Harunobu Iida, Hironari Hanaoka, Yusa Asari, Kana Ishimori, Tomofumi Kiyokawa, Yukiko Takakuwa, Yoshioki Yamasaki, Hidehiro Yamada, Takahiro Okazaki, Masatomo Doi, Shoichi Ozaki
Polyarteritis nodosa (PAN) is a medium vessel vasculitis affecting systemic organs. Muscle involvement of PAN usually lacks elevation of creatinine kinase (CK). We herein report a case of PAN with rhabdomyolysis. A 71-year-old man was hospitalized because of muscle weakness of the lower limbs that persisted for 1 month. On a physical examination, rapidly progressive lower proximal muscle weakness and bilateral drop foot were observed. His blood test showed an elevation in the C-reactive protein (CRP) (19.5 mg/dL) and CK (13,435 IU/L) levels and negativity for anti-neutrophilic cytoplasmic antibody (ANCA)...
October 11, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28993262/outcomes-7-years-after-infliximab-withdrawal-for-patients-with-crohn-s-disease-in-sustained-remission
#7
Catherine Reenaers, Jean-Yves Mary, Maria Nachury, Yoram Bouhnik, David Laharie, Matthieu Allez, Mathurin Fumery, Aurélien Amiot, Guillaume Savoye, Romain Altwegg, Martine Devos, Georgia Malamut, Arnaud Bourreille, Bernard Flourie, Philippe Marteau, Lucine Vuitton, Benoît Coffin, Stéphanie Viennot, Jérôme Lambert, Jean-Frédéric Colombel, Edouard Louis
BACKGROUND & AIMS: Little is known about long-term outcomes of patients with Crohn's disease (CD) after infliximab withdrawal. We aimed to describe the long-term outcomes of patients with CD in clinical remission after infliximab treatment was withdrawn. METHODS: We performed a retrospective analysis of data from the 115 patients included in the infliximab discontinuation in patients with CD in stable remission on combined therapy with anti-metabolites (STORI) study, performed at 20 centers in France and Belgium from March 2006 through December 2009...
October 6, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28988296/pivotal-factors-for-successful-withdrawal-of-nonsteroidal-anti-inflammatory-drugs-in-rheumatoid-arthritis-patients-in-remission-or-with-low-disease-activity
#8
Dong Jin Go, Kichul Shin, Han Joo Baek, Seong Wook Kang, Young Mo Kang, Jae Bum Jun, Yun Jong Lee, Sung Hwan Park, Yeong Wook Song
The purpose of this study is to examine the patient-reported outcomes (PRO) after discontinuing nonsteroidal anti-inflammatory drugs (NSAIDs) and clinical factors associated with a favorable outcome in patients with rheumatoid arthritis (RA) in remission or with low-disease activity (LDA). A 16-week prospective open-label trial was conducted at eight rheumatology clinics in Korea. RA patients with 28-joint disease activity score based on erythrocyte sedimentation rate (DAS28-ESR) < 3.2 who were on NSAIDs for more than a month were enrolled, and NSAIDs were discontinued...
October 8, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28982740/phase-ii-evaluation-of-anti-madcam-antibody-pf-00547659-in-the-treatment-of-crohn-s-disease-report-of-the-opera-study
#9
William J Sandborn, Scott D Lee, Dino Tarabar, Edouard Louis, Maria Klopocka, Jochen Klaus, Walter Reinisch, Xavier Hébuterne, Dong-Il Park, Stefan Schreiber, Satyaprakash Nayak, Alaa Ahmad, Anindita Banerjee, Lisa S Brown, Fabio Cataldi, Kenneth J Gorelick, John B Cheng, Mina Hassan-Zahraee, Robert Clare, Geert R D'Haens
OBJECTIVE: This phase II, randomised, double-blind, placebo-controlled clinical trial was designed to evaluate the efficacy and safety of PF-00547659, a fully human monoclonal antibody that binds to human mucosal addressin cell adhesion molecule (MAdCAM) to selectively reduce lymphocyte homing to the intestinal tract, in patients with moderate-to-severe Crohn's disease (CD). DESIGN: Eligible adults were aged 18-75 years, with active moderate-to-severe CD (Crohn's Disease Activity Index (CDAI) 220-450), a history of failure or intolerance to antitumour necrosis factor and/or immunosuppressive agents, high-sensitivity C reactive protein >3...
October 5, 2017: Gut
https://www.readbyqxmd.com/read/28975466/diabetes-outcomes-more-than-a-decade-following-sustained-weight-loss-after-laparoscopic-adjustable-gastric-band-surgery
#10
John M Wentworth, Chloe Cheng, Cheryl Laurie, Stewart Skinner, Paul R Burton, Wendy A Brown, Paul E O'Brien
BACKGROUND: Long-term outcome data are needed to define the role of bariatric surgery in type 2 diabetes (T2D). To address this, we collated diabetes outcomes more than a decade after laparoscopic adjustable gastric band (LAGB) surgery. METHOD: Clinical and biochemical measures from 113 obese T2D patients who underwent LAGB surgery in 2003 and 2004 were analyzed. Diabetes remission was defined as HbA1c < 6.2% (44 mmol/mol) and fasting glucose < 7.0 mmol/L...
October 3, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28974987/sustained-remission-in-rheumatoid-arthritis-latest-evidence-and-clinical-considerations
#11
REVIEW
Sofia Ajeganova, Tom Huizinga
Sustained remission is an ultimate treatment goal in the management of patients with rheumatoid arthritis (RA). Historically the frequency of sustained remission was low but the frequency of achieved sustained remission is increasing over time. The last years' clinical studies of tight control targeted treatment and intervention trials of early use of intensive strategy suggest that these treatment strategies are associated with higher rates of sustained remission. Achievement of sustained remission, in particular but not limited to early sustained remission, can provide tapering and stopping disease-modifying antirheumatic drugs (DMARDs)...
October 2017: Therapeutic Advances in Musculoskeletal Disease
https://www.readbyqxmd.com/read/28974885/defining-and-predicting-deep-remission-in-patients-with-perianal-fistulizing-crohn-s-disease-on-anti-tumor-necrosis-factor-therapy
#12
EDITORIAL
Konstantinos Papamichael, Adam S Cheifetz
Perianal fistulas can occur to up to one-third of patients with Crohn's disease (CD) leading to significant disabling disease and morbidity. Fistulising perianal CD treatment often necessitates a combined pharmacological and surgical approach. Anti-tumor necrosis factor (anti-TNF) therapy, particularly infliximab, has been shown to be very effective for both perianal and internal fistulising CD. Nevertheless, current data suggest that sustained remission and long-term complete fistula healing can be achieved in only 30% to 50% of patients...
September 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28974506/five-year-results-of-brentuximab-vedotin-in-patients-with-relapsed-or-refractory-systemic-anaplastic-large-cell-lymphoma
#13
Barbara Pro, Ranjana Advani, Pauline Brice, Nancy L Bartlett, Joseph D Rosenblatt, Tim Illidge, Jeffrey Matous, Radhakrishnan Ramchandren, Michelle Fanale, Joseph M Connors, Keenan Fenton, Dirk Huebner, Juan M Pinelli, Dana A Kennedy, Andrei Shustov
This pivotal phase 2 study evaluated the safety and efficacy of brentuximab vedotin in patients with relapsed or refractory systemic anaplastic large cell lymphoma (ALCL). After a median observation period of approximately 6 years from first treatment, we examined the durability of remission, progression-free survival (PFS), overall survival (OS), and safety outcomes of patients treated on this trial. Among all enrolled patients (N=58), no progressions were observed beyond 40 months, and median OS was not reached...
October 3, 2017: Blood
https://www.readbyqxmd.com/read/28970207/clinical-and-radiological-outcomes-of-5-year-drug-free-remission-steered-treatment-in-patients-with-early-arthritis-improved-study
#14
Gülşah Akdemir, Lotte Heimans, Sytske Anne Bergstra, Robbert J Goekoop, Maikel van Oosterhout, Johannes H L M van Groenendael, André J Peeters, Gerda M Steup-Beekman, Leroy R Lard, Peter B J de Sonnaville, Bernard A M Grillet, Tom W J Huizinga, Cornelia F Allaart
OBJECTIVES: To determine the 5-year outcomes of early remission induction therapy followed by targeted treatment aimed at drug-free remission (DFR) in patients with early arthritis. METHODS: In 12 hospitals, 610 patients with early (<2 years) rheumatoid arthritis (RA) or undifferentiated arthritis (UA) started on methotrexate (MTX) 25 mg/week and prednisone (60 mg/day tapered to 7.5 mg/day). Patients not in early remission (Disease Activity Score <1...
September 28, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28968858/optimizing-treatment-with-tumour-necrosis-factor-inhibitors-in-rheumatoid-arthritis-a-proof-of-principle-and-exploratory-trial-is-dose-tapering-practical-in-good-responders
#15
Fowzia Ibrahim, Beatriz Lorente-Cánovas, Caroline J Doré, Ailsa Bosworth, Margaret H Ma, James B Galloway, Andrew P Cope, Ira Pande, David Walker, David L Scott
Objectives: RA patients receiving TNF inhibitors (TNFi) usually maintain their initial doses. The aim of the Optimizing Treatment with Tumour Necrosis Factor Inhibitors in Rheumatoid Arthritis trial was to evaluate whether tapering TNFi doses causes loss of clinical response. Methods: We enrolled RA patients receiving etanercept or adalimumab and a DMARD with DAS28 under 3.2 for over 3 months. Initially (months 0-6) patients were randomized to control (constant TNFi) or two experimental groups (tapering TNFi by 33 or 66%)...
August 17, 2017: Rheumatology
https://www.readbyqxmd.com/read/28965131/efficacy-of-tocilizumab-highlighted-by-fdg-pet-ct-in-a-patient-with-relapsing-polychondritis-associated-aortitis
#16
REVIEW
Ghassan Elourimi, Michael Soussan, Ursula Warzocha, Hélène Bugaud, Robin Dhôte, Sébastien Abad
Relapsing polychondritis (RP) is a rare systemic inflammatory disease primarily affecting the ears, nose and tracheobronchial tree cartilage, but also the cardiovascular system. Cardiovascular complications are the second cause of mortality in RP. We report the case of a woman with a corticosteroid-resistant RP-associated aortitis, who was successfully treated with tocilizumab (TCZ). The FDG-PET/CT was a useful tool for diagnosing aortitis and assessing the effect of biotherapy. We conducted a systematic literature review confirming this is the first case of rapid and sustained remission in a patient with corticosteroid-resistant RP-associated aortitis after TCZ treatment administered as a first-line immunotherapy...
September 30, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28961693/sepsis-markers-soluble-il-2-receptor-and-soluble-cd14-subtype-as-potential-biomarkers-for-complete-mucosal-healing-in-patients-with-inflammatory-bowel-disease
#17
Shuhei Hosomi, Hirokazu Yamagami, Shigehiro Itani, Tomomi Yukawa, Koji Otani, Yasuaki Nagami, Fumio Tanaka, Koichi Taira, Noriko Kamata, Tetsuya Tanigawa, Masatsugu Shiba, Toshio Watanabe, Yasuhiro Fujiwara
Background and Aims: Novel noninvasive biomarkers with high diagnostic accuracy are required to assess mucosal healing, which is associated with sustained clinical remission, in inflammatory bowel disease. This study aimed to explore sepsis markers as potential biomarkers for mucosal healing. Methods: Patients with ulcerative colitis (UC) or Crohn's disease (CD) who underwent blood tests for C-reactive protein (CRP), serum procalcitonin (PCT) and soluble interleukin-2 receptor (sIL-2R), and plasma soluble CD14 subtype (sCD14-ST), within two weeks of endoscopy were retrospectively recruited and we assessed the relationship between marker levels and clinical features...
September 7, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28961308/nelarabine-induced-peripheral-and-central-neurotoxicity-can-sequential-mri-brain-imaging-help-to-define-its-natural-history
#18
Karl Ewins, Andrea Malone, Ethna Phelan, David Webb, J C McHugh, Owen Smith
A 14-year-old boy with relapsed T cell acute lymphoblastic leukaemia received reinduction chemotherapy that included nelarabine, a purine nucleoside analogue known to cause dose-dependent neurotoxicity. Although he achieved aminimal residual disease negative remission after two cycles of chemotherapy he also developed severe, progressive peripheral and central neurotoxicities. Loss of grey-white differentiation was seen on a T2-weighted magnetic resonance imaging brain scan. This unusual clinical picture and previously unreported radiological findings are thought to be due to nelarabine toxicity...
October 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28960869/impact-of-sustained-remission-on-the-risk-of-serious-infection-in-patients-with-rheumatoid-arthritis
#19
Neil A Accortt, Tamara Lesperance, Mei Liu, Sabrina Rebello, Mona Trivedi, Youfu Li, Jeffrey R Curtis
OBJECTIVE: This retrospective analysis examined how sustained remission impacted risk of serious infections in patients with rheumatoid arthritis (RA) enrolled in a clinical registry. METHODS: Inclusion criteria included RA diagnosis, ≥18 years old, and ≥2 clinical disease activity index (CDAI) scores followed by a follow-up visit. Index date was the second of 2 visits in which a patient had sustained remission (CDAI ≤2.8), low disease activity (LDA) (2.8<CDAI≤10), or moderate-to-high disease activity (MHDA) (CDAI>10)...
September 27, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28959775/improving-health-maintenance-supervision-in-a-paediatric-ibd-clinic
#20
Dana M H Dykes, Marie Raphaelle Jean, Pamela Morgan, Denise Hill, Elizabeth Williams, Lisa Opipari-Arigan, Jennifer Huggins, Shehzad A Saeed
BACKGROUND: Previsit planning (PVP) has been an integral part of clinical care for paediatric patients with inflammatory bowel disease (IBD) at Cincinnati Children's Hospital Medical Center since 2007. Over the past years, we have adopted several programmes to improve health maintenance supervision for our paediatric patients with IBD but did not have a sustainable way to provide health maintenance updates for every patient at every encounter that was concise and complete in the setting of an increasing patient population and fewer support staff to complete the work...
2017: BMJ Open Qual
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