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https://www.readbyqxmd.com/read/28422278/decipher-test-impacts-decision-making-among-patients-considering-adjuvant-and-salvage-treatment-after-radical-prostatectomy-interim-results-from-the-multicenter-prospective-pro-impact-study
#1
John L Gore, Marguerite du Plessis, María Santiago-Jiménez, Kasra Yousefi, Darby J S Thompson, Lawrence Karsh, Brian R Lane, Michael Franks, David Y T Chen, Mark Bandyk, Fernando J Bianco, Gordon Brown, William Clark, Adam S Kibel, Hyung L Kim, William Lowrance, Murugesan Manoharan, Paul Maroni, Scott Perrapato, Paul Sieber, Edouard J Trabulsi, Robert Waterhouse, Elai Davicioni, Yair Lotan, Daniel W Lin
BACKGROUND: Patients with prostate cancer and their providers face uncertainty as they consider adjuvant radiotherapy (ART) or salvage radiotherapy (SRT) after undergoing radical prostatectomy. The authors prospectively evaluated the impact of the Decipher test, which predicts metastasis risk after radical prostatectomy, on decision making for ART and SRT. METHODS: A total of 150 patients who were considering ART and 115 who were considering SRT were enrolled. Providers submitted a management recommendation before processing the Decipher test and again at the time of receipt of the test results...
April 19, 2017: Cancer
https://www.readbyqxmd.com/read/28409270/getting-the-first-degree-relatives-to-screen-for-colorectal-cancer-is-harder-than-it-seems-patients-and-their-first-degree-relatives-perspectives
#2
Ker-Kan Tan, Tian-Zhi Lim, Dedrick Kok Hong Chan, Emily Chew, Wen-Min Chow, Nan Luo, Mee-Lian Wong, Gerald Choon-Huat Koh
INTRODUCTION: First degree relatives (FDR) of colorectal cancer (CRC) patients are at increased risk of CRC compared to the general population. However, screening colonoscopy rates amongst the FDRs remain dismal. The aim of the study was to explore the various issues amongst the patients and their FDR precluding their adoption of screening colonoscopy. METHODS: A qualitative study of CRC patients and their FDRs was performed. Semi-structured interviews were conducted with participants using open-ended questions until data saturation was achieved...
April 13, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28397191/making-decisions-about-breast-reconstruction-a-systematic-review-of-patient-reported-factors-influencing-choice
#3
Kathy Flitcroft, Meagan Brennan, Andrew Spillane
PURPOSE: Many studies have explored women's reasons for choosing or declining a particular type of breast reconstruction (BR) following mastectomy for breast cancer. This systematic review synthesises women's reasons for choosing a range of BR options, including no BR, in different settings and across time. METHODS: Thirteen databases were systematically searched, with 30 studies (4269 participants), meeting the selection criteria. Information on study aim and time frame, participation rate, design/methods, limitations/bias, reasons and conclusions, as well as participant clinical and demographic information, was reported...
April 10, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28393710/rolapitant-a-nk-1-receptor-antagonist-for-the-prevention-of-chemotherapy-induced-nausea-and-vomiting
#4
Bernardo Leon Rapaport
BACKGROUND: Nausea and vomiting are among the most feared side effects of chemotherapy and can prevent cancer patients from completing their treatment regimens. Rolapitant is a highly selective neurokinin-1 (NK-1) receptor antagonist with very good oral activity, central nervous system penetration and a long (180-hour) plasma half-life. Unlike other available NK-1 receptor antagonists, rolapitant does not inhibit or induce cytochrome P450 (CYP) 3A4. METHODS: Findings from recent phase II and III clinical trials of rolapitant in patients receiving highly or moderately emetogenic chemotherapy are reviewed and discussed...
April 6, 2017: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/28391710/does-psychosocial-stress-exacerbate-avoidant-responses-to-cancer-information-in-those-who-are-afraid-of-cancer-a-population-based-survey-among-older-adults-in-england
#5
Charlotte Vrinten, David Boniface, Siu Hing Lo, Lindsay C Kobayashi, Christian von Wagner, Jo Waller
OBJECTIVE: Communication of cancer information is an important element of cancer control, but cancer fear may lead to information avoidance, especially when coping is low. We examined the association between cancer fear and cancer information avoidance, and tested whether this was exacerbated by psychosocial stress. DESIGN: Cross-sectional survey of 1258 population-based adults (58-70 years) in England. MAIN OUTCOME MEASURES: Cancer fear (intensity and frequency), perceived psychosocial stress and cancer information avoidance...
April 9, 2017: Psychology & Health
https://www.readbyqxmd.com/read/28386772/predictors-of-the-course-of-quality-of-life-during-therapy-in-women-with-primary-breast-cancer
#6
Achim Wöckel, L Schwentner, M Krockenberger, R Kreienberg, W Janni, M Wischnewsky, Kühn Thorsten, Flock Felix, Felberbaum Riccardo, M Blettner, S Singer
PURPOSE: Multimodal therapies affect the quality of life (QoL) of patients with primary breast cancer (PBC). The objectives of this prospective study were to explore the changes in QoL from diagnosis to conclusion of adjuvant therapy and to identify predictive factors of QoL. METHODS: Before surgery (t1), before onset of adjuvant treatment (t2) and after completion of adjuvant chemo- or radiotherapy (t3), patients with PBC (n = 759) completed the European Organization for Research and Treatment of Cancer Quality of Life Core Questionnaire, Charlson Comorbidity Index, Patient Health Questionnaire and Perceived Involvement in Care Scales...
April 6, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28378659/helping-people-to-live-better-with-and-beyond-bowel-cancer
#7
Claire Taylor
Do your patients ever worry about getting caught short? Does the fear of being faecally incontinent stop them from going to work or socialising?
April 5, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28372960/the-kiel-concept-of-long-term-administration-of-daily-low-dose-sildenafil-initiated-in-the-immediate-post-prostatectomy-period-evaluation-and-comparison-with-the-international-literature-on-penile-rehabilitation
#8
REVIEW
Daniar K Osmonov, Klaus P Jünemann, Andreas Bannowsky
INTRODUCTION: Radical prostatectomy (RP) is the most common definitive invasive treatment option for localized prostate cancer. Although the different surgical procedures-open RP, laparoscopic RP, and robot-assisted laparoscopic RP-do not differ significantly for the results of postoperative erectile dysfunction (ED) and continence, the fear of losing erectile function (EF) is often an important factor for preoperatively sexually active men when deciding for or against a procedure. AIM: To review the available literature on rehabilitation of EF after RP and to evaluate the value of the "Kiel concept" against different strategies of phosphodiesterase type 5 inhibitor (PDE5i) low-dose treatments...
March 31, 2017: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/28368770/barriers-to-medical-help-seeking-among-older-men-with-prostate-cancer
#9
L Medina-Perucha, O Yousaf, M S Hunter, E A Grunfeld
OBJECTIVE: Men's disinclination to seek medical help has been linked to higher rates of morbidity and mortality compared to women. However, previous studies were conducted predominantly with healthy, young, and middle-aged men. We explored the perceived medical barriers to help-seeking in older men with prostate cancer. METHOD: Twenty men with prostate cancer took part in semi-structured interviews, which were analysed using thematic analysis. RESULTS: Three themes were identified related to negative attitudes towards help-seeking: male gender role; fear of the health condition, medical and treatment procedures; and embarrassment as a consequence of medical examinations, communication with health (and non-health) professionals, and the disclosure of sexual-related symptoms...
April 3, 2017: Journal of Psychosocial Oncology
https://www.readbyqxmd.com/read/28355365/the-acceptability-of-vaginal-smear-self-collection-for-screening-for-cervical-cancer-a-systematic-review
#10
Natalia Serrano Doratioto Faria Braz, Noely Paula Cristina Lorenzi, Isabel Cristina Esposito Sorpreso, Lana Maria de Aguiar, Edmund Chada Baracat, José Maria Soares-Júnior
Cervical cancer is a major cause of death in adult women. However, many women do not undergo cervical cancer screening for the following reasons: fear, shame, physical limitations, cultural or religious considerations and lack of access to health care services. Self-collected vaginal smears maybe an alternative means of including more women in cervical cancer screening programs. The objective of this systematic review was to evaluate the acceptability of vaginal smear self-collection for cervical cancer screening...
March 2017: Clinics
https://www.readbyqxmd.com/read/28343838/cancer-screening-and-early-detection-in-older-people-considerations-for-nursing-practice
#11
REVIEW
Sarah H Kagan, Kristen W Maloney
OBJECTIVE: To synthesize relevant issues in cancer screening for older people for nursing practice. DATA SOURCES: Published scientific literature, clinical literature, and published cancer screening guidelines from the United States and Canada. CONCLUSION: Nurses are caring for increasing numbers of older patients and, with this demographic shift, face increasing demands to address cancer screening and detection in both primary and specialty practice...
March 23, 2017: Seminars in Oncology Nursing
https://www.readbyqxmd.com/read/28342628/poor-sleep-quality-depression-and-hope-before-breast-cancer-surgery
#12
Thalyta Cristina Mansano-Schlosser, Maria Filomena Ceolim, Teresa D Valerio
AIM: This study aims to identify the predictors of poor sleep quality and the associations between depression, hope and sleep in a sample of 156 women with breast cancer prior to surgery. BACKGROUND: The care and treatment of breast cancer is among the most important scientific challenges in public health. Sleep disturbances and depression are the important complaint of cancer patients. However, they are often neglected. Patients diagnosed with breast cancer also experience prejudice, fear of death, suffering, mutilation, fear of lymphedema, as well as feelings of social devaluation leading to hopelessness Several studies point to hope as an effective strategy to help patients cope with difficulties and achieve their goals, especially patients with cancer...
April 2017: Applied Nursing Research: ANR
https://www.readbyqxmd.com/read/28342616/performance-of-leading-artifact-removal-algorithms-assessed-across-microwave-breast-imaging-prototype-scan-configurations
#13
M A Elahi, C Curtis, B R Lavoie, M Glavin, E Jones, E Fear, M O'Halloran
Microwave imaging is a promising imaging modality for the detection of early-stage breast cancer. One of the most important signal processing components of microwave radar-based breast imaging is early-stage artifact removal. Several artifact removal algorithms have been reported in the literature. However, the neighbourhood-based skin subtraction and hybrid artifact removal algorithms have shown particularly promising results in different realistic 3D breast phantoms. For the first time in this paper, both algorithms have been evaluated and compared using the scan approaches of the most common microwave breast imaging prototype systems...
March 2, 2017: Computerized Medical Imaging and Graphics: the Official Journal of the Computerized Medical Imaging Society
https://www.readbyqxmd.com/read/28334436/impact-of-neoadjuvant-chemoradiation-on-perioperative-outcomes-in-patients-with-rectal-cancer
#14
Brandon C Chapman, Patrick Hosokawa, William Henderson, Alessandro Paniccia, Douglas M Overbey, Wells Messersmith, Christopher Lieu, Greg V Stiegmann, Richard D Schulick, Csaba Gajdos
BACKGROUND AND OBJECTIVES: Neoadjuvant chemoradiation for rectal cancer is associated with lower local recurrence rates. The objective of this study is to assess the impact of neoadjuvant therapy on perioperative complications in patients with rectal cancer. METHODS: Using the ACS-NSQIP database (2005-2012), a propensity score was used to match 3592 patients with rectal cancer receiving neoadjuvant therapy to 3592 patients undergoing surgery alone. The association between neoadjuvant chemoradiation and perioperative outcomes was evaluated...
March 23, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28328269/physical-activity-and-exercise-after-stoma-surgery-overcoming-the-barriers
#15
Sarah Russell
This article presents the results from a large nationwide survey completed in 2016 that investigated the physical health and wellbeing of people living with stomas in the UK. In particular, the survey looked at physical activity and exercise, general attitudes and opinions about exercise, whether or not advice about physical activity had been received and other general questions about parastomal hernia and quality of life. There were 2631 respondents making it one of the largest known surveys to date. The findings were concerning yet unsurprising, highlighting a trend toward inactivity after stoma surgery and a fear of exercise in general...
March 9, 2017: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/28327090/investigating-young-women-s-motivations-to-engage-in-early-mammography-screening-in-switzerland-results-of-a-cross-sectional-study
#16
Nanon H M Labrie, Ramona Ludolph, Peter J Schulz
BACKGROUND: The scientific and public debate concerning organized mammography screening is unprecedentedly strong. With research evidence concerning its efficacy being ambiguous, the recommendations pertaining to the age-thresholds for program inclusion vary between - and even within - countries. Data shows that young women who are not yet eligible for systematic screening, have opportunistic mammograms relatively often and, moreover, want to be included in organized programs. Yet, to date, little is known about the precise motivations underlying young women's desire and intentions to go for, not medically indicated, mammographic screening...
March 21, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28326215/osteoradionecrosis-of-the-temporal-bone-leading-to-cerebellar-abscess
#17
Thomas B Layton
Squamous cell carcinoma of the temporal bone is a rare and destructive malignancy and represents both diagnostic and therapeutic challenge. The complex regional anatomy of the temporal bone requires equally intricate surgical techniques to adequately resect the tumour mass during surgical excision. Adjuvant radiotherapy is offered to patients with advanced disease and has been showed to confer a survival benefit in carefully selected patients. One feared complication of radiotherapy is osteoradionecrosis and is a major obstacle faced in the treatment of head and neck cancers...
2017: Case Reports in Otolaryngology
https://www.readbyqxmd.com/read/28324266/quality-of-life-in-patients-with-recurrent-breast-cancer-after-second-breast-conserving-therapy-in-comparison-with-mastectomy-the-german-experience
#18
Svenja Jendrian, Katharina Steffens, Barbara Schmalfeldt, Elena Laakmann, Corinna Bergelt, Isabell Witzel
BACKGROUND: Although some studies suggest that breast-conserving therapy (BCT) shows better psychosocial outcomes than mastectomy in patients with primary breast cancer, little is known about the outcomes of these surgical options in recurrent breast cancer. We investigated differences in overall survival and re-recurrence rates as well as psychosocial outcomes among patients who underwent BCT or mastectomy after the diagnosis of recurrent breast cancer in a single-center setting. METHODS: 124 of 186 eligible patients who underwent surgical treatment for breast cancer recurrence completed the questionnaires on quality of life (EORTC QLQ-C30 and -BR23), fear of progression (PA-F-KF), anxiety and depression (HADS), and body image (BIS)...
March 21, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28317267/fear-of-cancer-recurrence-a-significant-concern-among-partners-of-prostate-cancer-survivors
#19
Marieke van de Wal, Simône Langenberg, Marieke Gielissen, Belinda Thewes, Inge van Oort, Judith Prins
OBJECTIVES: The aims of the study were to (1) describe the prevalence of fear of cancer recurrence (FCR) in partners of prostate cancer (PCa) survivors; (2) to compare the proportions of high FCR in partners with high FCR in PCa survivors; (3) to explore partners' demographic and survivors' clinical characteristics associated with high FCR in partners; and (4) to identify the relationship between high FCR and health-related quality of life (HRQoL) in partners. METHODS: Questionnaires were sent to partners of disease-free PCa survivors...
March 20, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28315539/scalp-cooling-a-literature-review-of-efficacy-safety-and-tolerability-for-chemotherapy-induced-alopecia%C3%A2
#20
Mikel Ross, Erica Fischer-Cartlidge
BACKGROUND: More than 75% of patients with cancer cite alopecia as the most feared side effect of treatment, with as many as 10% considering treatment refusal. Despite wide acceptance in other countries, scalp cooling to reduce chemotherapy-induced alopecia (CIA) has been uncommon in the United States because of longstanding concerns of scalp metastases and a lack of reliable efficacy data. 
. OBJECTIVES: This article reviews 40 years of efficacy, safety, and tolerability literature on scalp cooling to prevent CIA...
April 1, 2017: Clinical Journal of Oncology Nursing
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