keyword
https://read.qxmd.com/read/37041206/pharmacogenetic-activation-of-parvalbumin-interneurons-in-the-prefrontal-cortex-rescues-cognitive-deficits-induced-by-adolescent-mk801-administration
#21
JOURNAL ARTICLE
Linda A Chamberlin, Sha-Sha Yang, Erin P McEachern, Joshua T M Lucas, Owen W McLeod Ii, Claire A Rolland, Nancy R Mack, Brielle R Ferguson, Wen-Jun Gao
The cognitive symptoms of schizophrenia (SZ) present a significant clinical burden. They are treatment resistant and are the primary predictor of functional outcomes. Although the neural mechanisms underlying these deficits remain unclear, pathological GABAergic signaling likely plays an essential role. Perturbations with parvalbumin (PV)-expressing fast-spiking (FS) interneurons in the prefrontal cortex (PFC) are consistently found in post-mortem studies of patients with SZ, as well as in animal models. Our studies have shown decreased prefrontal synaptic inhibition and PV immunostaining, along with working memory and cognitive flexibility deficits in the MK801 model...
April 11, 2023: Neuropsychopharmacology
https://read.qxmd.com/read/37017330/differential-role-of-oxidative-stress-in-synaptic-and-nonsynaptic-in-vitro-ictogenesis
#22
JOURNAL ARTICLE
Mogens Andreasen, Steen Nedergaard
It is well established that dysfunctional glucose metabolism and in particular hypoglycemia can lead to hyperexcitability and exacerbate epileptic seizures. The precise mechanisms behind this form of hyperexcitability is still unresolved. The present study investigate to what extent oxidative stress can account for the acute proconvulsant effect of hypoglycemia. We used the glucose derivative 2-deoxy-D-glucose (2-DG) to mimic glucose deprivation in hippocampal slices during extracellular recording of interictal-like (IED) and seizure-like (SLE) epileptic discharge in area CA3 and CA1...
April 5, 2023: Journal of Neurophysiology
https://read.qxmd.com/read/36990270/theta-gamma-co-modulation-disruption-after-nmdar-blockade-by-mk801-is-associated-with-spatial-working-memory-deficits-in-mice
#23
JOURNAL ARTICLE
P Abad-Perez, F J Molina-Payá, L Martínez-Otero, V Borrell, R L Redondo, J R Brotons-Mas
Abnormal N-methyl-D-aspartate receptor (NMDAr) function has been linked to oscillopathies, psychosis, and cognitive dysfunction in schizophrenia (SCZ). Here, we investigate the role of NMDAr hypofunction in pathological oscillations and behavior. We implanted mice with tetrodes in the dorsal/intermediate hippocampus and medial prefrontal cortex (mPFC), administered the NMDAr antagonist MK-801, and recorded oscillations during spontaneous exploration in an open field and in the y-maze spatial working memory test...
March 28, 2023: Neuroscience
https://read.qxmd.com/read/36931729/glutamatergic-and-gabaergic-receptor-modulation-present-unique-electrophysiological-fingerprints-in-a-concentration-dependent-and-region-specific-manner
#24
JOURNAL ARTICLE
Irene Gonzalez-Burgos, Marie Bainier, Simon Gross, Philipp Schoenenberger, José A Ochoa-Martinez, Miguel Valencia, Roger L Redondo
Brain function depends on complex circuit interactions between excitatory and inhibitory neurons embedded in local and long-range networks. Systemic GABAA-receptor or NMDA-receptor modulation alters the excitatory/inhibitory balance (EIB), measurable with electroencephalography (EEG). However, EEG signatures are complex in localization and spectral composition. We developed and applied analytical tools to investigate the effects of two EIB modulators, MK801 (NMDAR-antagonist) and diazepam (GABAAR-modulator), on periodic and aperiodic EEG features in freely-moving male Sprague-Dawley rats...
March 16, 2023: ENeuro
https://read.qxmd.com/read/36891608/oleic-acid-induced-interleukin-36%C3%AE-a-possible-link-between-facial-skin-redness-and-sebum
#25
JOURNAL ARTICLE
Akane Kawamoto, Tetsuya Kuwano, Etsuko Watarai, Takanori Igarashi, Yasushi Katayama, Ken Kushida, Shun Nakamura, Takatoshi Murase, Hiroyuki Yoshida, Junko Ishikawa
BACKGROUND: Redness of the facial skin is an important cosmetic concern. Although qualitative and quantitative modifications of sebum on the skin surface are major pathogenic factors of chronic inflammatory skin conditions, the relationship between skin redness, sebum, and mild inflammation on the cheeks of healthy subjects remains elusive. AIMS: We aimed to explore the correlation between cheek redness and sebum and inflammatory cytokines in the stratum corneum (SC) of healthy subjects...
March 8, 2023: Journal of Cosmetic Dermatology
https://read.qxmd.com/read/36867359/inactivation-of-erk1-2-creb-pathway-is-implicated-in-mk801-induced-cognitive-impairment
#26
JOURNAL ARTICLE
Cui-Ping Guo, Wen-Sheng Li, Yi Liu, Yacoubou Abdoul Razak Mahaman, Bin Zhang, Jian-Zhi Wang, Rong Liu, Hong-Lian Li, Xiao-Chuan Wang, Xiang Gao
OBJECTIVE: Schizophrenia (SZ) is associated with cognitive impairment, and it is known that the activity of cAMP response element binding protein (CREB) decreases in the brain of SZ patients. The previous study conducted by the investigators revealed that the upregulation of CREB improves the MK801-related SZ cognitive deficit. The present study further investigates the mechanism on how CREB deficiency is associated with SZ-related cognitive impairment. METHODS: MK-801 was used to induce SZ in rats...
February 2023: Current Medical Science
https://read.qxmd.com/read/36774369/nmdars-antagonist-mk801-suppresses-lps-induced-apoptosis-and-mitochondrial-dysfunction-by-regulating-subunits-of-nmdars-via-the-cam-camkii-erk-pathway
#27
JOURNAL ARTICLE
Wei-Min Han, Xiao-Bin Hao, Yi-Xiang Hong, Shan-Shan Zhao, Xu-Chang Chen, Ruiying Wang, Yan Wang, Gang Li
Lipopolysaccharide (LPS) displays a robust immunostimulatory ability upon Toll-like receptor 4 (TLR4) recognition. N-methyl-D-aspartate receptors (NMDARs) are highly compartmentalized in most cells and implicated in various inflammatory disorders. However, the relationship between TLR4 and NMDARs has not been explored deeply. This study aimed to examine the role of NMDARs and its specific inhibitor MK801 in LPS-treated endothelial cell dysfunction and the related mechanism in vivo and in vitro. The results showed that pre-treatment with MK801 significantly decreased LPS-induced cell death, cellular Ca2+ , cellular reactive oxygen species, and glutamate efflux...
February 11, 2023: Cell Death Discovery
https://read.qxmd.com/read/36758782/-anti-cancer-effect-of-ketamine-in-comparison-with-mk801-on-neuroglioma-and-lung-cancer-cells
#28
JOURNAL ARTICLE
Junichi Saito, Hailin Zao, Lingzhi Wu, Masae Iwasaki, Qizhe Sun, Cong Hu, Masashi Ishikawa, Kazuyoshi Hirota, Daqing Ma
Ketamine, a N-methyl-D-aspartate (NMDA) receptor antagonist, is commonly used to induce anaesthesia during cancer surgery and relieve neuropathic and cancer pain. This study was conducted to assess whether ketamine has any inhibiting effects on neuroglioma (H4) and lung cancer cells (A549) in vitro. The cultured H4 and A549 cells were treated with ketamine and MK801 (0.1, 1, 10, 100, or 1000 μM) for 24 h. The expressions of glutamate receptors on both types of cancer cells were assessed with qRT-PCR...
February 7, 2023: European Journal of Pharmacology
https://read.qxmd.com/read/36703609/spreading-depolarization-causes-reperfusion-failure-after-cerebral-ischemia
#29
JOURNAL ARTICLE
Anna Törteli, Réka Tóth, Sarah Berger, Sarah Samardzic, Ferenc Bari, Ákos Menyhárt, Eszter Farkas
Despite successful recanalization, reperfusion failure associated with poor neurological outcomes develops in half of treated stroke patients. We explore here whether spreading depolarization (SD) is a predictor of reperfusion failure. Global forebrain ischemia/reperfusion was induced in male and female C57BL/6 mice (n = 57). SD and cerebral blood flow (CBF) changes were visualized with transcranial intrinsic optical signal and laser speckle contrast imaging. To block SD, MK801 was applied (n = 26)...
January 26, 2023: Journal of Cerebral Blood Flow and Metabolism
https://read.qxmd.com/read/36656044/dopamine-agonist-cotreatment-alters-neuroplasticity-and-pharmacology-of-levodopa-induced-dyskinesia
#30
JOURNAL ARTICLE
Elena Espa, Lu Song, Katrine Skovgård, Silvia Fanni, M Angela Cenci
BACKGROUND: Current models of levodopa (L-dopa)-induced dyskinesia (LID) are obtained by treating dopamine-depleted animals with L-dopa. However, patients with LID receive combination therapies that often include dopamine agonists. OBJECTIVE: Using 6-hydroxydopamine-lesioned rats as a model, we aimed to establish whether an adjunct treatment with the D2/3 agonist ropinirole impacts on patterns of LID-related neuroplasticity and drug responses. METHODS: Different regimens of L-dopa monotreatment and L-dopa-ropinirole cotreatment were compared using measures of hypokinesia and dyskinesia...
January 19, 2023: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/36500684/an-efficient-solid-phase-microextraction-gas-chromatography-mass-spectrometry-method-for-the-analysis-of-methyl-farnesoate-released-in-growth-medium-by-daphnia-pulex
#31
JOURNAL ARTICLE
Nicolò Riboni, Antonio Suppa, Annamaria Buschini, Federica Bianchi, Valeria Rossi, Gessica Gorbi, Maria Careri
Methyl farnesoate (MF), a juvenile hormone, can influence phenotypic traits and stimulates male production in daphnids. MF is produced endogenously in response to stressful conditions, but it is not known whether this hormone can also be released into the environment to mediate stress signaling. In the present study, for the first time, a reliable solid-phase microextraction-gas chromatography-mass spectrometry (SPME-GC-MS) method was developed and validated for the ultra-trace analysis of MF released in growth medium by Daphnia pulex maintained in presence of crowding w/o MK801, a putative upstream inhibitor of MF endogenous production...
December 6, 2022: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/36424738/protective-effects-of-shi-zhen-an-shen-decoction-on-the-cognitive-impairment-in-mk801-induced-schizophrenia-model
#32
JOURNAL ARTICLE
Xinyao Liu, Sitong Feng, Zhengtian Feng, Chao Ma, Yi He, Xue Li, Yanzhe Ning, Zuoli Sun, Hongxiao Jia
BACKGROUND: Cognitive dysfunction is a core feature of schizophrenia that strongly correlates to the patients' difficulties in independent living and occupational functioning. Synaptic dysfunction may result in cognitive and behavioral changes similar to what have been identified in schizophrenia. Shi-Zhen-An-Shen Decoction (SZASD) is the empirical formula of traditional Chinese medicine adopted in treating psychiatric symptoms, especially the cognitive impairment in schizophrenia patients, with proven efficacy in the long term of clinical practice in Beijing Anding Hospital, Capital Medical University...
September 27, 2022: Journal of Integrative Neuroscience
https://read.qxmd.com/read/36402255/involvement-of-gabaergic-glutamatergic-opioidergic-and-brain-derived-neurotrophic-factor-systems-in-the-trigeminal-neuropathic-pain-process
#33
JOURNAL ARTICLE
Fabrício Finamor, Vanessa Leal Scarabelot, Liciane Fernandes Medeiros, Dirson João Stein, Morgana Duarte da Silva, Etiane Callai, Wolnei Caumo, Andressa de Souza, Iraci Ls Torres
Trigeminal neuropathic pain (TNP) is an intense pain condition characterized by hyperalgesia and allodynia; however, its neural mechanisms are not completely understood. Its management is complex, and studies that investigate its biochemical mechanisms are important for improving clinical approaches. This study aimed to evaluate the involvement of GABAergic, glutamatergic, and opioidergic systems and brain-derived neurotrophic factor (BDNF) levels in the TNP process in rats. TNP is induced by chronic constriction injury of the infraorbital nerve (CCI-ION)...
November 16, 2022: Neuroscience Letters
https://read.qxmd.com/read/36359279/isoflurane-rescue-schizophrenia-related-deficits-through-parvalbumin-positive-neurons-in-the-dentate-gyrus
#34
JOURNAL ARTICLE
Hualing Peng, Jie Jia, Yisheng Lu, Hua Zheng
The therapeutic effects of volatile anesthetics on mental diseases, particularly schizophrenia, have gained considerable interest. Although isoflurane is a commonly used volatile anesthetic, there's no more evidence that it could work on treating schizophrenia. Here, we discovered that inhaling isoflurane at low concentrations might reverse the behavioral phenotypes of schizophrenia caused by MK801, such as hyperlocomotion, pre-pulse inhibition impairment, and working memory loss. Isoflurane also helped recovering adult neurogenesis and synaptic plasticity impairments in the dentate gyrus (DG) induced by MK801...
October 31, 2022: Biomedicines
https://read.qxmd.com/read/36291328/embryonic-deletion-of-txnip-in-gabaergic-neurons-enhanced-oxidative-stress-in-pv-interneurons-in-primary-somatosensory-cortex-of-aging-mice-relevance-to-schizophrenia
#35
JOURNAL ARTICLE
Ting Xue, Xiaodan Wang, Ying Hu, Ying Cheng, Han Li, Yuan Shi, Lijun Wang, Dongmin Yin, Donghong Cui
The brain is susceptible to perturbations of redox balance, affecting neurogenesis and increasing the risks of psychiatric disorders. Thioredoxin-interacting protein (TXNIP) is an endogenous inhibitor of the thioredoxin antioxidant system. Its deletion or inhibition suggests protection for a brain with ischemic stroke or Alzheimer's disease. Combined with conditional knockout mice and schizophrenia samples, we aimed to investigate the function of TXNIP in healthy brain and psychiatric disorders, which are under-studied...
October 15, 2022: Brain Sciences
https://read.qxmd.com/read/36284385/upregulation-of-connexins-in-the-rat-hippocampal-and-cortical-neurons-following-blockade-of-nmda-receptors-during-postnatal-development
#36
JOURNAL ARTICLE
Masoumeh Kourosh-Arami, Mansoureh Soleimani, Mohammad Taghi Joghataei, Farideh Mosleh, Parisa Hayat, Alireza Komaki
BACKGROUND: Interneural gap junctional coupling is a representation of neural development that decreases during the postnatal period. The decrease of gap junctions function coincides with the main period of chemical synapse creation and increment of synaptic activity during postnatal weeks 1 to 3. METHODS: Here we have assessed the role of chemical synapses on the expression of connexin (Cx) in neurons and glial cells of hippocampal and cortical neurons. We characterized the impact of NMDA receptors blockade on the expression of Cx36 and Cx43 proteins by western blot analysis in postnatal day (PND)14 and PND28...
October 24, 2022: Protein and Peptide Letters
https://read.qxmd.com/read/36232749/the-antidepressant-like-activity-effects-on-recognition-memory-deficits-bioavailability-and-safety-after-chronic-administration-of-new-dual-acting-small-compounds-targeting-neuropsychiatric-symptoms-in-dementia
#37
JOURNAL ARTICLE
Magdalena Jastrzębska-Więsek, Magdalena Kotańska, Aleksandra Grzeszczak, Anna Jaromin, Maria Walczak, Anna Partyka, Joanna Gdula-Argasińska, Magdalena Smolik, Agnieszka Zagórska
This study aimed to extend the body of preclinical research on prototype dual-acting compounds combining the pharmacophores relevant for inhibiting cyclic nucleotide phosphodiesterase 10 (PDE10A) and serotonin 5-HT1A /5-HT7 receptor (5-HT1A R/5-HT7 R) activity into a single chemical entity (compounds PQA-AZ4 and PQA-AZ6). After i.v. administration of PQA-AZ4 and PQA-AZ6 to rats, the brain to plasma ratio was 0.9 and 8.60, respectively. After i.g. administration, the brain to plasma ratio was 5.7 and 5.3, respectively...
September 28, 2022: International Journal of Molecular Sciences
https://read.qxmd.com/read/36216056/effects-of-urban-particulate-matter-on-gut-microbiome-and-partial-schizophrenia-like-symptoms-in-mice-evidence-from-shotgun-metagenomic-and-metabolomic-profiling
#38
JOURNAL ARTICLE
Weizhuo Yi, Yifu Ji, Hua Gao, Shengyong Luo, Rubing Pan, Jian Song, Yangyang He, Yuxuan Li, Yudong Wu, Shuangshuang Yan, Yunfeng Liang, Xiaoni Sun, Xiaoyu Jin, Lu Mei, Jian Cheng, Hong Su
BACKGROUND: Epidemiological evidence reported that particulate matter (PM) was associated with increased schizophrenia (SCZ) risk. Disturbance of gut microbiome was involved in SCZ. However, it remains unclear whether PM induces SCZ-like symptoms and how gut microbiome regulates them. Therefore, a multi-omics animal experiment was conducted to verify how urban PM induces SCZ-like behavior and altered gut microbiota and metabolic pathways. METHODS: Using a completely random design, mice were divided into three groups: PM group, control group and MK801 group, which received daily tracheal instillation of PM solution, sterile PBS solution and intraperitoneal injection of MK801 (establish SCZ model), respectively...
October 7, 2022: Science of the Total Environment
https://read.qxmd.com/read/36162671/electrical-stimulus-combined-with-venlafaxine-and-mirtazapine-improves-brain-ca-2-activity-pre-pulse-inhibition-and-immobility-time-in-a-model-of-major-depressive-disorder-in-schizophrenia
#39
JOURNAL ARTICLE
Chuanjun Zhuo, Chunhua Zhou, Ziyao Cai, Jiayue Chen, Lei Yang, Qianchen Li, Qiuyu Zhang, Tao Fang, Hongjun Tian, Chongguang Lin, Xueqin Song
BACKGROUND: The prevalence of major depressive disorder in patients with schizophrenia (SZ-MDD) has been reported to be about 32.6 %, but it varies considerably depending on the stage (early or chronic) and state (acute or post-psychotic) of schizophrenia. The exploration of ideal strategies for the treatment of major depressive disorder in the context of schizophrenia is urgently needed. Thus, the present study was conducted to investigate the treatment effects of clozapine, electrical stimulation (ECS; the mouse model equivalent of electroconvulsive therapy for humans), venlafaxine, and mirtazapine for SZ-MDD...
September 23, 2022: Journal of Affective Disorders
https://read.qxmd.com/read/36139568/met-oncogene-controls-invasive-growth-by-coupling-with-nmda-receptor
#40
JOURNAL ARTICLE
Simona Gallo, Annapia Vitacolonna, Paolo Comoglio, Tiziana Crepaldi
The N-methyl-D-aspartate receptor (NMDAR) is a glutamate-gated ion channel involved in excitatory synaptic transmission. Outside the nervous system, the NMDAR is expressed in a variety of tissues and in cancers, notably in the highly invasive and metastatic triple-negative breast carcinoma. MET encodes the tyrosine kinase receptor for HGF and is a master regulator gene for "invasive growth". In silico analysis shows that high expression of the NMDAR2B subunit is a negative prognostic factor in human invasive breast carcinoma...
September 11, 2022: Cancers
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