Weizhuo Yi, Yifu Ji, Hua Gao, Shengyong Luo, Rubing Pan, Jian Song, Yangyang He, Yuxuan Li, Yudong Wu, Shuangshuang Yan, Yunfeng Liang, Xiaoni Sun, Xiaoyu Jin, Lu Mei, Jian Cheng, Hong Su
BACKGROUND: Epidemiological evidence reported that particulate matter (PM) was associated with increased schizophrenia (SCZ) risk. Disturbance of gut microbiome was involved in SCZ. However, it remains unclear whether PM induces SCZ-like symptoms and how gut microbiome regulates them. Therefore, a multi-omics animal experiment was conducted to verify how urban PM induces SCZ-like behavior and altered gut microbiota and metabolic pathways. METHODS: Using a completely random design, mice were divided into three groups: PM group, control group and MK801 group, which received daily tracheal instillation of PM solution, sterile PBS solution and intraperitoneal injection of MK801 (establish SCZ model), respectively...
October 7, 2022: Science of the Total Environment