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Keywords Advances in gastrointestinal s...

Advances in gastrointestinal surgery

https://read.qxmd.com/read/38488694/in-vivo-intelligent-fluorescence-endo-microscopy-by-varifocal-meta-device-and-deep-learning
#21
JOURNAL ARTICLE
Yu-Hsin Chia, Wei-Hao Liao, Sunil Vyas, Cheng Hung Chu, Takeshi Yamaguchi, Xiaoyuan Liu, Takuo Tanaka, Yi-You Huang, Mu Ku Chen, Wen-Shiang Chen, Din Ping Tsai, Yuan Luo
Endo-microscopy is crucial for real-time 3D visualization of internal tissues and subcellular structures. Conventional methods rely on axial movement of optical components for precise focus adjustment, limiting miniaturization and complicating procedures. Meta-device, composed of artificial nanostructures, is an emerging optical flat device that can freely manipulate the phase and amplitude of light. Here, an intelligent fluorescence endo-microscope is developed based on varifocal meta-lens and deep learning (DL)...
March 15, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38485756/future-direction-of-total-neoadjuvant-therapy-for-locally-advanced-rectal-cancer
#22
REVIEW
Yoshinori Kagawa, J Joshua Smith, Emmanouil Fokas, Jun Watanabe, Andrea Cercek, Florian R Greten, Hideaki Bando, Qian Shi, Julio Garcia-Aguilar, Paul B Romesser, Natally Horvat, Hanna Sanoff, William Hall, Takeshi Kato, Claus Rödel, Arvind Dasari, Takayuki Yoshino
Despite therapeutic advancements, disease-free survival and overall survival of patients with locally advanced rectal cancer have not improved in most trials as a result of distant metastases. For treatment decision-making, both long-term oncologic outcomes and impact on quality-of-life indices should be considered (for example, bowel function). Total neoadjuvant therapy (TNT), comprised of chemotherapy and radiotherapy or chemoradiotherapy, is now a standard treatment approach in patients with features of high-risk disease to prevent local recurrence and distant metastases...
March 14, 2024: Nature Reviews. Gastroenterology & Hepatology
https://read.qxmd.com/read/38485589/a-population-based-analysis-on-the-incidence-of-metachronous-colon-cancer-after-endoscopic-resection-of-advanced-adenomas-with-high-grade-dysplasia-does-location-matter
#23
JOURNAL ARTICLE
Sonja Boatman, Julia Kohn, Sarah L Mott, Wolfgang B Gaertner, Robert D Madoff, Genevieve B Melton, Aasma Shaukat, Imran Hassan, Paolo Goffredo
BACKGROUND: Advanced adenomas (AAs) with high-grade dysplasia (HGD) represent a risk factor for metachronous neoplasia, with guidelines recommending short-interval surveillance. Although the worse prognosis of proximal (vs distal) colon cancers (CCs) is established, there is paucity of evidence on the impact of laterality on the risk of subsequent neoplasia for these AAs. METHODS: Adults with HGD adenomas undergoing polypectomy were identified in the Surveillance, Epidemiology, and End Results database (2000-2019)...
February 19, 2024: Journal of Gastrointestinal Surgery
https://read.qxmd.com/read/38482243/the-long-term-outcomes-and-prognostic-factors-about-locally-advanced-right-colon-cancer-a-retrospective-cohort-study
#24
JOURNAL ARTICLE
Changzheng Li, Zhenyu Li, Jiachen Zhang, Xijie Zhang, Matthew Yuan-Kun Wei, Nan Zun Teo, Pengfei Ma, Junli Zhang, Sen Li, Zhi Li, Yuzhou Zhao
BACKGROUND: The first case of treatment with en bloc right hemicolectomy with pancreatoduodenectomy (RHCPD) for locally advanced right-sided colon cancer (LARCC) invading the pancreas, duodenum, or other organs, was reported in 1953 by Van Prohaska. Right-sided colon cancers invading the pancreas and duodenum are rare. Surgery can be technically challenging, with unclear oncologic consequences, hence there are few reports on the clinical outcomes and factors associated with survival in this patient cohort...
February 29, 2024: Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38482226/retrospective-study-of-combined-pelvic-exenteration-in-the-treatment-of-primary-and-recurrent-pelvic-malignant-tumors
#25
JOURNAL ARTICLE
Changzheng Li, Zhenyu Li, Jiachen Zhang, Xijie Zhang, Gabriele Siesto, Sen Li, Pengfei Ma, Junli Zhang, Zhi Li, Yuzhou Zhao
BACKGROUND: Pelvic malignant tumors often originate in the rectum, bladder, uterus, and other organs. In patients with locally advanced tumours in the presence of direct invasion of one or more organs, negative tumor resection margin (R0) resection can be very beneficial to patient survival if it can be performed. As a multidisciplinary and high-risk surgical method, the pelvic exenteration (PE) procedure has only been reported in a few medical centres internationally. We retrospectively analyzed the clinical data of patients who had undergone PE surgery in our hospital, in order to provide ideas for the best treatment of patients with pelvic malignant tumors...
February 29, 2024: Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38480587/the-gist-of-it-all-management-of-gastrointestinal-stromal-tumors-gist-from-the-first-steps-to-tailored-therapy-a-bibliometric-analysis
#26
JOURNAL ARTICLE
Julian Musa, Sarah M Kochendoerfer, Franziska Willis, Christine Sauerteig, Jonathan M Harnoss, Ingmar F Rompen, Thomas G P Grünewald, Mohammed Al-Saeedi, Martin Schneider, Julian-C Harnoss
PURPOSE: Improvement of patient care is associated with increasing publication numbers in biomedical research. However, such increasing numbers of publications make it challenging for physicians and scientists to screen and process the literature of their respective fields. In this study, we present a comprehensive bibliometric analysis of the evolution of gastrointestinal stromal tumor (GIST) research, analyzing the current state of the field and identifying key open questions going beyond the recent advantages for future studies to assess...
March 14, 2024: Langenbeck's Archives of Surgery
https://read.qxmd.com/read/38477364/shear-wave-elastography-for-monitoring-fontan-associated-liver-disease-a-prospective-cohort-study
#27
JOURNAL ARTICLE
Rishi Bolia, Sara Alremawi, Charlton Noble, Robert Justo, Cameron Ward, Peter J Lewindon
The spectrum of Fontan-associated liver disease (FALD) varies from abnormal liver function tests to fibrosis and even cirrhosis. In this prospective study, we evaluated the role of shear-wave elastography (SWE) in predicting the presence of advanced FALD. Forty-eight patients (30 males, 13.9 [6-21] years) with a Fontan circulation were evaluated at 8.3 (2.1-18.7) years since the Fontan surgery. The median liver stiffness measurement (LSM) value was higher than values in normal children at 15.4 (9.5-38.7) kPa...
March 13, 2024: Journal of Pediatric Gastroenterology and Nutrition
https://read.qxmd.com/read/38476156/groove-pancreatitis-clinical-cases-and-review-of-the-literature
#28
Catarina Neto do Nascimento, Carolina Palmela, António Sampaio Soares, Maria Lobo Antunes, Catarina Andrade Fidalgo, Luísa Glória
INTRODUCTION: Groove pancreatitis (GP) is a type of chronic segmental pancreatitis that affects the pancreatoduodenal groove area, and it is often misdiagnosed. Outflow obstruction of the minor papilla associated with alcohol consumption seems to be the main pathophysiological mechanism, and it affects mainly middle-aged males. Symptoms include nausea and postprandial vomiting from gastric outlet obstruction, weight loss, and abdominal pain. Despite modern advances, such as radiological and endoscopic methods, distinction between GP and pancreatic cancer remains a challenge, and histological examination is sometimes necessary...
December 2023: GE Portuguese Journal of Gastroenterology
https://read.qxmd.com/read/38472947/the-many-hidden-faces-of-gallbladder-carcinoma-on-ct-and-mri-imaging-from-a-to-z
#29
JOURNAL ARTICLE
Damaris Neculoiu, Lavinia Claudia Neculoiu, Ramona Mihaela Popa, Rosana Mihaela Manea
Gallbladder carcinoma represents the most aggressive biliary tract cancer and the sixth most common gastrointestinal malignancy. The diagnosis is a challenging clinical task due to its clinical presentation, which is often non-specific, mimicking a heterogeneous group of diseases, as well as benign processes such as complicated cholecystitis, xanthogranulomatous cholecystitis, adenomyomatosis, porcelain gallbladder or metastasis to the gallbladder (most frequently derived from melanoma, renal cell carcinoma)...
February 22, 2024: Diagnostics
https://read.qxmd.com/read/38468341/metastatic-melanoma-to-small-bowel-metastasectomy-is-supported-in-the-era-of-immunotherapy-and-checkpoint-inhibitors
#30
JOURNAL ARTICLE
Paul Wong, Andrew D Wisneski, Katy K Tsai, Tammy T Chang, Kenzo Hirose, Eric K Nakakura, Adil I Daud, Ajay V Maker, Carlos U Corvera
BACKGROUND: Metastatic melanoma to the small bowel is an aggressive disease often accompanied by obstruction, abdominal pain, and gastrointestinal bleeding. With advancements in melanoma treatment, the role for metastasectomy continues to evolve. Inclusion of novel immunotherapeutic agents, such as checkpoint inhibitors, into standard treatment regimens presents potential survival benefits for patients receiving metastasectomy. CASE PRESENTATION: We report an institutional experience of 15 patients (12 male, 3 female) between 2014-2022 that underwent small bowel metastasectomy for metastatic melanoma and received perioperative systemic treatment...
March 11, 2024: World Journal of Surgical Oncology
https://read.qxmd.com/read/38465042/advanced-and-metastatic-gastrointestinal-stromal-tumors-presenting-with-surgical-emergencies-managed-with-surgical-resection-a-case-series
#31
Divij Jayant, Mrinal Goyal, Vipul Thakur, Swapnesh Sahu, Basil Babu, Satish Subbiah Nagaraj, Cherring Tandup, Arunanshu Behera
Advanced and metastatic gastrointestinal stromal tumors (GISTs) presenting with surgical emergencies are rare. Neoadjuvant imatinib being the treatment of choice for non-metastatic advanced disease with a proven role in downstaging the disease may not be feasible in patients presenting with bleeding and obstruction. We present a case series with retrospective analysis of a prospectively maintained database of patients with advanced and metastatic GISTs presenting with surgical emergencies. Clinical characteristics, imaging and endoscopic findings, surgical procedures, histological findings, and outcomes in these patients were studied...
February 2024: Curēus
https://read.qxmd.com/read/38463378/efficacy-and-safety-of-endoscopic-submucosal-dissection-for-early-gastric-cancer-and-precancerous-lesions-in-elderly-patients
#32
JOURNAL ARTICLE
Wen-Si Xu, Hui-Yu Zhang, Shuang Jin, Qi Zhang, Hong-Dan Liu, Ming-Tao Wang, Bo Zhang
BACKGROUND: With advancements in the development of endoscopic technologies, the endoscopic submucosal dissection (ESD) has been one of the gold-standard therapies for early gastric cancer. AIM: To investigate the efficacy and safety ESD in the treatment of early gastric cancer and precancerous lesions in the elderly patients. METHODS: Seventy-eight elderly patients with early gastric cancer and precancerous lesions admitted to the Third Affiliated Hospital of Qiqihar Medical University were selected and classified into two groups according to the different surgical therapies they received between January 2021 and June 2022...
February 27, 2024: World Journal of Gastrointestinal Surgery
https://read.qxmd.com/read/38463374/laparoscopic-left-hemihepatectomy-guided-by-indocyanine-green-fluorescence-a-cranial-dorsal-approach
#33
JOURNAL ARTICLE
Xing-Ru Wang, Xiao-Ju Li, Dan-Dan Wan, Qian Zhang, Tian-Xi Liu, Zong-Wen Shen, Hong-Xing Tong, Yan Li, Jian-Wei Li
BACKGROUND: Advancements in laparoscopic technology and a deeper understanding of intrahepatic anatomy have led to the establishment of more precise laparoscopic hepatectomy (LH) techniques. The indocyanine green (ICG) fluorescence navigation technique has emerged as the most effective method for identifying hepatic regions, potentially overcoming the limitations of LH. While laparoscopic left hemihepatectomy (LLH) is a standardized procedure, there is a need for innovative strategies to enhance its outcomes...
February 27, 2024: World Journal of Gastrointestinal Surgery
https://read.qxmd.com/read/38463363/risk-stratification-in-gastric-cancer-lung-metastasis-utilizing-an-overall-survival-nomogram-and-comparing-it-with-previous-staging
#34
JOURNAL ARTICLE
Zhi-Ren Chen, Mei-Fang Yang, Zhi-Yuan Xie, Pei-An Wang, Liang Zhang, Ze-Hua Huang, Yao Luo
BACKGROUND: Gastric cancer (GC) is prevalent and aggressive, especially when patients have distant lung metastases, which often places patients into advanced stages. By identifying prognostic variables for lung metastasis in GC patients, it may be possible to construct a good prediction model for both overall survival (OS) and the cumulative incidence prediction (CIP) plot of the tumour. AIM: To investigate the predictors of GC with lung metastasis (GCLM) to produce nomograms for OS and generate CIP by using cancer-specific survival (CSS) data...
February 27, 2024: World Journal of Gastrointestinal Surgery
https://read.qxmd.com/read/38463361/ileal-collision-tumor-associated-with-gastrointestinal-bleeding-a-case-report-and-review-of-literature
#35
Yu-Qi Wu, Hong-Yan Wang, Mu-Min Shao, Lin Xu, Xiao-Yan Jiang, Shao-Ju Guo
BACKGROUND: Collision tumors involving the small intestine, specifically the combination of a hamartomatous tumor and a lipoma, are extremely rare. To our knowledge, no previous case report has described a collision tumor composed of two benign tumors of different origins in the small intestine. CASE SUMMARY: Here, we present the case of an 82-year-old woman who presented with hemorrhagic shock and was found to have a mass measuring approximately 50 mm × 32 mm × 30 mm in the terminal ileum...
February 27, 2024: World Journal of Gastrointestinal Surgery
https://read.qxmd.com/read/38463354/nomogram-model-including-lats2-expression-was-constructed-to-predict-the-prognosis-of-advanced-gastric-cancer-after-surgery
#36
JOURNAL ARTICLE
Nan Sun, Bi-Bo Tan, Yong Li
BACKGROUND: Gastric cancer is a leading cause of cancer-related deaths worldwide. Prognostic assessments are typically based on the tumor-node-metastasis (TNM) staging system, which does not account for the molecular heterogeneity of this disease. LATS2 , a tumor suppressor gene involved in the Hippo signaling pathway, has been identified as a potential prognostic biomarker in gastric cancer. AIM: To construct and validate a nomogram model that includes LATS2 expression to predict the survival prognosis of advanced gastric cancer patients following radical surgery, and compare its predictive performance with traditional TNM staging...
February 27, 2024: World Journal of Gastrointestinal Surgery
https://read.qxmd.com/read/38463346/development-of-a-clinical-nomogram-for-prediction-of-response-to-neoadjuvant-chemotherapy-in-patients-with-advanced-gastric-cancer
#37
JOURNAL ARTICLE
Bing Liu, Yu-Jie Xu, Feng-Ran Chu, Guang Sun, Guo-Dong Zhao, Sheng-Zhong Wang
BACKGROUND: The efficacy of neoadjuvant chemotherapy (NAC) in advanced gastric cancer (GC) is still a controversial issue. AIM: To find factors associated with chemosensitivity to NAC treatment and to provide the optimal therapeutic strategies for GC patients receiving NAC. METHODS: The clinical information was collected from 230 GC patients who received NAC treatment at the Central South University Xiangya School of Medicine Affiliated Haikou Hospital from January 2016 to December 2020...
February 27, 2024: World Journal of Gastrointestinal Surgery
https://read.qxmd.com/read/38463225/case-report-pathological-complete-response-of-pregnancy-associated-pulmonary-enteric-adenocarcinoma-to-chemoradiotherapy
#38
Yukiko Nemoto, Koji Kuroda, Rintaro Oyama, Masataka Mori, Shohei Shimajiri, Fumihiro Tanaka
Pulmonary enteric adenocarcinoma (PEAC) is a rare lung adenocarcinoma with morphological features similar to those of primary and metastatic colorectal adenocarcinoma. To date, only a few studies have reported the therapeutic effects of chemoradiotherapy on PEAC. This report describes the case of a 28-year-old woman with pregnancy-related PEAC who presented with left shoulder pain. A superior sulcus tumor was identified in the left thoracic cavity, and the biopsy indicated more than 50% intestinal differentiation components...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38462424/tampa-difficulty-score-a-novel-scoring-system-for-difficulty-of-robotic-hepatectomy
#39
JOURNAL ARTICLE
Iswanto Sucandy, Michelle M Dugan, Sharona B Ross, Cameron Syblis, Kaitlyn Crespo, Parisa Yazdankhah Kenary, Alexander Rosemurgy
BACKGROUND: Difficulty scoring system (DSS) has been established for laparoscopic hepatectomy and serves as useful tools to predict difficulty and guide preoperative planning. Despite increased adoption of robotics and its unique technical characteristics compared with laparoscopy, no DSS currently exists for robotic hepatectomy. We aimed to introduce a new DSS for robotic hepatectomy. METHODS: A total of 328 patients undergoing a robotic hepatectomy were identified...
February 19, 2024: Journal of Gastrointestinal Surgery
https://read.qxmd.com/read/38455498/clinical-impact-of-very-early-recurrence-after-conversion-surgery-for-stage-iv-gastric-cancer
#40
JOURNAL ARTICLE
Atsushi Morito, Kojiro Eto, Masaaki Iwatsuki, Tasuku Toihata, Keisuke Kosumi, Shiro Iwagami, Yoshifumi Baba, Yuji Miyamoto, Naoya Yoshida, Hideo Baba
BACKGROUND: The development and improved response to chemotherapy has resulted in a survival benefit of conversion surgery (CS) for advanced gastric cancer (GC). However, this benefit is limited in some cases, such as in those with very early recurrence (VER). This study investigated the relationship between outcome and clinicopathological characteristics after CS for stage IV GC, and the risk factors for VER after CS. METHODS: We retrospectively studied 184 patients with stage IV GC who initially underwent chemotherapy, including 36 patients who underwent CS between May 2007 and January 2022...
March 2024: Annals of Gastroenterological Surgery
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