Yoshinori Kagawa, J Joshua Smith, Emmanouil Fokas, Jun Watanabe, Andrea Cercek, Florian R Greten, Hideaki Bando, Qian Shi, Julio Garcia-Aguilar, Paul B Romesser, Natally Horvat, Hanna Sanoff, William Hall, Takeshi Kato, Claus Rödel, Arvind Dasari, Takayuki Yoshino
Despite therapeutic advancements, disease-free survival and overall survival of patients with locally advanced rectal cancer have not improved in most trials as a result of distant metastases. For treatment decision-making, both long-term oncologic outcomes and impact on quality-of-life indices should be considered (for example, bowel function). Total neoadjuvant therapy (TNT), comprised of chemotherapy and radiotherapy or chemoradiotherapy, is now a standard treatment approach in patients with features of high-risk disease to prevent local recurrence and distant metastases...
March 14, 2024: Nature Reviews. Gastroenterology & Hepatology