Ian Davis, Jackie M Payne, Victoria L Olguin, Madison P Sanders, Tamara Clements, Christopher P Stefan, Janice A Williams, Jay W Hooper, John W Huggins, Eric M Mucker, Keersten M Ricks
Human monkeypox (mpox) has recently become a global public health emergency; however, assays that detect mpox infection are not widely available, largely due to cross-reactivity within the Orthopoxvirus genus. Immunoassay development was largely confined to researchers who focus on biothreats and endemic areas (Central and West Africa) until the 2022 outbreak. As was noted in the COVID-19 pandemic, antigen detection assays, integrated with molecular assays, are necessary to help curb the spread of disease. Antigen-detecting immunoassays offer the advantage of providing results ranging from within min to h and in lateral flow formats; they can be deployed for point-of-care, home, or field use...
2023: Frontiers in Microbiology