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I-131 Therapy

Min Liu, Lingxiao Cheng, Yuchen Jin, Maomei Ruan, Shiwei Sheng, Libo Chen
The quantitative relationship between iodine and glucose metabolism in metastases from differentiated thyroid cancer (DTC) remains unknown. Aim of the prospective study was to establish the value of18 F-FDG PET/CT in predicting131 I-avidity of metastases from DTC before the first radioiodine therapy. A total of 121 postoperative DTC patients with elevated stimulated serum thyroglobulin (ssTg) who underwent131 I adjuvant therapy or therapy after18 F-FDG PET/CT scan were enrolled. The Receiver operating characteristic curve was established to create an optimal cut-off point and evaluate the value of SUVmax for predicting131 I-avidity...
March 12, 2018: Scientific Reports
Pingyan Jin, Huijuan Feng, Wei Ouyang, Juqing Wu, Pan Chen, Jing Wang, Yungang Sun, Jialang Xian, Liuhua Huang
Postoperative131 I treatment for differentiated thyroid cancer (DTC) can create a radiation hazard for nearby persons. The present prospective study aimed to investigate radiation dose rates in131 I-treated DTC patients to provide references for radiation protection. A total of 141131 I-treated DTC patients were enrolled, and grouped into a singular treatment (ST) group and a repeated treatment (RT) group. The radiation dose rate of131 I-treated patients was measured. The rate of achieving discharge compliance and restricted contact time were analyzed based on Chinese regulations...
March 10, 2018: Radiation and Environmental Biophysics
Christopher J Udell, Julie L Ruddy, Philip M Procento
Introduction: US Navy recruits who have injuries preventing them from participating in intense physical conditioning are pulled out of boot camp training and receive treatment that includes daily physical therapy, pain medications, and psychoeducational groups. Graduation from boot camp for these recruits requires not only recovering from their injuries but also passing a required Physical Fitness Assessment consisting of a timed 1.5-mile run, curl-ups, and push-ups. About 50-60% of these recruits will eventually be separated out and sent home...
March 6, 2018: Military Medicine
Kosma Woliński, Rafał Czepczyński, Adam Stangierski, Maciej Trojanowski, Magdalena Rewaj-Łosyk, Katarzyna Ziemnicka, Maciej Bączyk, Agnieszka Dyzmann-Sroka, Marek Ruchała
INTRODUCTION: Due to a limited number of hospital beds dedicated to radioiodine therapy (RIT) in some countries, a fractionated dose of radioiodine may be considered as the ablation therapy of differentiated thyroid cancer (DTC). The aim of the study was to compare the late effects of ablation therapy with single and fractionated dose of radioiodine in patients with DTC. PATIENTS AND METHODS: Patients with low-risk DTC referred to our institution 5-16 weeks after thyroidectomy, treated with 2...
March 5, 2018: Endokrynologia Polska
Angela Spanu, Susanna Nuvoli, Ilaria Gelo, Luciana Mele, Bastiana Piras, Giuseppe Madeddu
Papillary thyroid microcarcinoma (PTMC) usually presents favourable prognosis, but it can also be aggressive with neck and distant metastases. We evaluated the diagnostic role of131 I-single photon emission computed tomography/computed tomography (SPECT/CT) in detecting metastases in PTMC patients in long-term follow-up and whether the procedure may be included in the current diagnostic protocol. Methods: We retrospectively studied 351 consecutive PTMC patients already submitted to thyroidectomy and radioiodine therapy; 21/351 patients were at high risk (H), 94 at low risk (L) and 236 at very low risk (VL)...
March 1, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Yugui Tao, Longlong Zhu, Yunayuan Zhao, Xuan Yi, Longbao Zhu, Fei Ge, Xiaozhou Mou, Lei Chen, Liang Sun, Kai Yang
While radiotherapy (RT) is commonly used in clinics for cancer treatment, the therapeutic efficiency is not satisfactory owing to the existence of the hypoxic tumor microenvironment which seriously affects the efficiency of RT. Herein, we design polyethylene glycol (PEG)-modified reduced nano-graphene oxide-manganese dioxide (rGO-MnO2 -PEG) nanocomposites to trigger oxygen generation from H2 O2 to reduce the tumor hypoxic microenvironments. We use the radioisotope,131 I labeled rGO-MnO2 -PEG nanocomposites as therapeutic agents for in vivo tumor radioisotope therapy (RIT), achieving excellent tumor killing and further enhancing the therapeutic efficiency of RIT...
February 28, 2018: Nanoscale
G Favia, A Tempesta, L Limongelli, V Crincoli, E Maiorano
Medication-related osteonecrosis of the jaw (MRONJ) is a severe side effect of antiresorptive (bisphosphonates and denosumab) and anti-angiogenic therapy used in the management of oncologic and, less frequently, osteoporotic patients. While there is good international agreement on the diagnostic and staging criteria of MRONJ and the cessation of antiresorptive/anti-angiogenic treatments, the gold standard of treatment is still controversial, in particular between non-surgical and surgical approaches. The former usually includes antiseptic mouth rinse, cyclic antibiotic therapy, low-level laser therapy and periodic dental checks; the latter consists of surgical necrotic bone removal...
March 2018: Oral Diseases
Najeeb Ahmed, Kashif Niyaz, Aditya Borakati, Fahad Marafi, Rubinder Birk, Sharjeel Usmani
Differentiated thyroid cancer (DTC) has a good prognosis overall; however, lifelong follow-up is required for many cases. Radioiodine planar imaging with iodine-123 (I-123) or radioiodine-131 (I-131) remains the standard in the follow-up after initial surgery and ablation of residual thyroid tissue using I-131 therapy. Radioiodine imaging is also used in risk-stratifying and for staging of thyroid cancer, and in long-term follow-up. Unfortunately, the lack of anatomical detail on planar gamma camera imaging and superimposition of areas presenting with increased radioiodine uptake can make accurate diagnosis and localization of radioiodine-avid metastatic disease challenging, leading to false positive results and potentially to over-treatment of patients...
February 26, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Rui Guo, Yun Xi, Min Zhang, Ying Miao, Miao Zhang, Biao Li
Novel treatment options are urgently required for patients with glioma who are not effectively treated through standard therapy. Human sodium iodide symporter (hNIS) is a molecular target of certain tumors types. Compared with131 I,188 Re possesses a higher energy and shorter half-life; therefore, the effects of188 Re and131 I were compared in hNIS-mediated gene imaging and therapy in the present study. Recombinant human brain glioma cell line U87 was transfected with a recombinant lentiviral vector containing hNIS (U87-hNIS)...
March 2018: Oncology Letters
Lixia Zhang, Jinyan Chen, Caiyun Xu, Lili Qi, Yan Ren
T helper 17 (Th17), T cytotoxic 17 (Tc17) and regulatory T (Treg) cells serve important roles in a number of inflammatory and autoimmune diseases. The aim of the present study was to examine the distribution of Th17, Tc17 and Treg cells in patients with differentiated thyroid cancer (DTC) prior to as well as 7, 30 and 90 days following radioactive iodine-131 (131 I) therapy, and to elucidate the probable effects of131 I therapy on Th17/Tc17 and Treg/Th17 cells in patients with DTC. A total of 40 patients with DTC (26 female; 14 male) between the ages of 24 and 72 years, as well as 13 age- and sex-matched healthy subjects were included in this study...
March 2018: Experimental and Therapeutic Medicine
Rang Wang, Ke Zhou, Qiuping Fan, Haotian Chen, Chengzhong Fan
RATIONALE: Iodine-131 (I-131) is a sensitive marker for the detection of differentiated thyroid cancer (DTC). I-131 whole-body scintigraphy (WBS) has been used widely in evaluation of DTC patient. However, I-131 WBS exists many false-positive uptake of I-131 because radioiodine uptake can also be seen in healthy tissue or in a variety of benign and malignant non-thyroidal tumors. PATIENT CONCERNS: A 44-year-old woman with a papillary thyroid carcinoma for the purpose of ablation therapy after a total thyroidectomy...
February 2018: Medicine (Baltimore)
Hsing-I Chiang, Siew-Na Lim, Hsiang-Yao Hsieh, Mei-Yun Cheng, Chun-Wei Chang, Wei-En Johnny Tseng, Han-Tao Li, Chin-Yin Lin, Tony Wu
BACKGROUND: To analyze the efficacy and safety of perampanel over a 3-month period in a sample of Asian people with epilepsy. METHODS: The efficacy and safety of perampanel as an adjunctive therapy for patients with epilepsy were retrospectively reviewed and analyzed. Patients were categorized according to seizure type, concomitant antiepileptic drug usage, and perampanel dosage. RESULTS: A total of 210 patients were included in the study and 131 patients completed 3 months of perampanel treatment...
December 2017: Biomedical Journal
Francisco Javier Navas González, Jordi Jordana Vidal, Jose Manuel León Jurado, Amy Katherine McLean, Gabriela Pizarro Inostroza, Juan Vicente Delgado Bermejo
Genetic analyses in donkeys are likely to face compromises in terms of sample size and population structure. This study aims at implementing a suitable model to estimate breeding values and genetic parameters for gaits in Andalusian donkeys. Empirical observation revealed that ambling donkeys (showing a slightly uneven, non-isochronous 1-2, 3-4 lateral sequence gait) did not walk (i.e. presented an isochronous, even 1-2-3-4 sequence gait) and vice versa. However, the two donkey groups could trot, equally. In this study, 2700 gait records were registered from 300 donkeys...
February 12, 2018: Veterinary Research Communications
Yi-Yi Xuan, Tian-Fang Li, Lei Zhang, Sheng-Yun Liu
RATIOINALE: Relapsing polychondritis (RP) is a rare and heterogeneous disease complex of unknown origin which basically affects cartilaginous structures, 40% of which accompanied by rheumatic, hematologic, and endocrine disease. Among them, vasculitis is the most common accompanying type and usually presented with positive antineutrophilic cytoplasmic antibody (ANCA). The presence of ANCA could be primary or drug-induced like propylthiouracil (PTU). Central involvement of RP is very rare, and there is almost no report of cerebral vasculopathy manifested as moyamoya...
December 2017: Medicine (Baltimore)
D Tsai, A A Udy, P C Stewart, S Gourley, N M Morick, J Lipman, J A Roberts
Augmented renal clearance (ARC) refers to the enhanced renal excretion of circulating solute commonly demonstrated in numerous critically ill subgroups. This study aimed to describe the prevalence of ARC in critically ill Indigenous Australian patients and explore the accuracy of commonly employed mathematical estimates of glomerular filtration. We completed a single-centre, prospective, observational study in the intensive care unit (ICU), Alice Springs Hospital, Central Australia. Participants were critically ill adult Indigenous and non-Indigenous Australian patients with a urinary catheter in situ...
January 2018: Anaesthesia and Intensive Care
E Abma, K Peremans, F De Vos, T Bosmans, A M Kitshoff, S Daminet, Y Ni, R Dockx, H de Rooster
Hypericin (Hyp) is a necrosis-avid compound that can be efficiently labelled with radioiodine for both diagnostic and therapeutic purposes. Before 131 I-Hyp can be considered as a clinically useful drug in a combination therapy for canine cancer patients, evaluation of its toxicity is necessary. The aim of this study was to investigate the biodistribution and tolerance of a single dose administration of 131 I-Hyp. Three healthy dogs were included. 131 I-Hyp at a dose of 0.2 mg/kg and an activity of 185 MBq was intravenously injected...
January 4, 2018: Veterinary and Comparative Oncology
Krawczuk-Rybak Maryna, Panasiuk Anna, Stachowicz-Stencel Teresa, Zubowska Małgorzata, Skalska-Sadowska Jolanta, Sęga-Pondel Dorota, Czajńska-Deptuła Aneta, Sławińska Dorota, Badowska Wanda, Kamieńska Elżbieta, Pobudejska-Pieniążek Aneta, Wieczorek Maria
In the last 40 years, considerable progress was made in the treatment of childhood cancer. Nearly 80% of children achieve long-term clinical remission or are permanently cured. This improvement is however not without sacrifice. This is the first Polish study analyzing the general health status and epidemiology of organ late effects in the cohort of Polish childhood and adolescent cancer survivors monitored by doctors and registered in the on-line national database for late effects (N = 1761). This tool collects information on previous therapy and current health status (medical history, physical examination, laboratory tests) of cancer survivors...
December 22, 2017: European Journal of Pediatrics
Anping Ji, Yuanchao Zhang, Gaochao Lv, Jianguo Lin, Ning Qi, Faquan Ji, Minghua Du
For the purpose of providing a new insights for high-efficiency radiochemotherapy of hepatoma, a radioimmunotherapy and chemotherapy combinatorial therapy albumin nanospheres 131 I-antiAFPMcAb-DOX-BSA-NPs was designed and prepared. It was obtained in a high radiolabeling yield (RLY) about 65% with the radiochemical purity (RCP) of over 98%. The transmission electron microscope (TEM) showed that the nanospheres obtained in good monodispersion with a diameter of approximately 230 nm. The doxorubicin (DOX) loading capacity of the DOX-BSA-NPs nanoparticles was determined to about 180 μg/mg and 95...
December 16, 2017: Journal of Labelled Compounds & Radiopharmaceuticals
Jane Caldwell, Lorne Gula, Fariha Sadiq Ali, Rodrigo I Miranda, Hoshiar Abdollah, Adrian Baranchuk, Kevin Michael, Christopher Simpson, Damian P Redfearn
BACKGROUND: Despite improving algorithms, inappropriate shocks for supraventricular arrhythmias (SVT) still occur in a significant number of patients with implantable cardioverter defibrillators (ICD). This makes the discovery of novel discriminators that use existing ICD hardware, an attractive proposition. OBJECTIVE: We hypothesised that the delay of activation onset from the device detected, far field electrogram(EGM) to the near field, bipole EGM would allow differentiation of ventricular tachycardias (VT) from SVTs...
December 12, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Changhai Cheng, Jinxin Zhou, Xiaonan Shao
RATIONALE: Multiple primary malignant tumors (MPMTs) are defined as 2 or more independent primary malignancies of different histologies/origins in the same individual. Although the incidence of MPMTs is being increasing, second primary cancer (SPC) is still rare and difficult to distinguish from metastasis. Here, we present a case of thyroid carcinoma with lung metastasis and primary lung cancer. PATIENTS CONCERNS: The patient was a 66-year-old man diagnosed of papillary thyroid carcinoma (PTC) with lymph nodes, lung, and skeletons metastases...
December 2017: Medicine (Baltimore)
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