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I-131 Therapy

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https://www.readbyqxmd.com/read/29314561/biodistribution-and-tolerance-of-intravenous-iodine-131-labelled-hypericin-in-healthy-dogs
#1
E Abma, K Peremans, F De Vos, T Bosmans, A M Kitshoff, S Daminet, Y Ni, R Dockx, H de Rooster
Hypericin (Hyp) is a necrosis-avid compound that can be efficiently labelled with radioiodine for both diagnostic and therapeutic purposes. Before 131 I-Hyp can be considered as a clinically useful drug in a combination therapy for canine cancer patients, evaluation of its toxicity is necessary. The aim of this study was to investigate the biodistribution and tolerance of a single dose administration of 131 I-Hyp. Three healthy dogs were included. 131 I-Hyp at a dose of 0.2 mg/kg and an activity of 185 MBq was intravenously injected...
January 4, 2018: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/29273944/health-status-of-polish-children-and-adolescents-after-cancer-treatment
#2
Krawczuk-Rybak Maryna, Panasiuk Anna, Stachowicz-Stencel Teresa, Zubowska Małgorzata, Skalska-Sadowska Jolanta, Sęga-Pondel Dorota, Czajńska-Deptuła Aneta, Sławińska Dorota, Badowska Wanda, Kamieńska Elżbieta, Pobudejska-Pieniążek Aneta, Wieczorek Maria
In the last 40 years, considerable progress was made in the treatment of childhood cancer. Nearly 80% of children achieve long-term clinical remission or are permanently cured. This improvement is however not without sacrifice. This is the first Polish study analyzing the general health status and epidemiology of organ late effects in the cohort of Polish childhood and adolescent cancer survivors monitored by doctors and registered in the on-line national database for late effects (N = 1761). This tool collects information on previous therapy and current health status (medical history, physical examination, laboratory tests) of cancer survivors...
December 22, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29247459/131-i-radiolabeled-immune-albumin-nanospheres-loaded-with-doxorubicin-for-in-vivo-combinatorial-therapy
#3
Anping Ji, Yuanchao Zhang, Gaochao Lv, Jianguo Lin, Ning Qi, Faquan Ji, Minghua Du
For the purpose of providing a new insights for high-efficiency radiochemotherapy of hepatoma, a radioimmunotherapy and chemotherapy combinatorial therapy albumin nanospheres 131 I-antiAFPMcAb-DOX-BSA-NPs was designed and prepared. It was obtained in a high radiolabeling yield (RLY) about 65% with the radiochemical purity (RCP) of over 98%. The transmission electron microscope (TEM) showed that the nanospheres obtained in good monodispersion with a diameter of approximately 230 nm. The doxorubicin (DOX) loading capacity of the DOX-BSA-NPs nanoparticles was determined to about 180 μg/mg and 95...
December 16, 2017: Journal of Labelled Compounds & Radiopharmaceuticals
https://www.readbyqxmd.com/read/29246830/relative-timing-of-near-field-and-far-field-electrograms-can-determine-tachyarrhythmia-site-of-origin
#4
Jane Caldwell, Lorne Gula, Fariha Sadiq Ali, Rodrigo I Miranda, Hoshiar Abdollah, Adrian Baranchuk, Kevin Michael, Christopher Simpson, Damian P Redfearn
BACKGROUND: Despite improving algorithms, inappropriate shocks for supraventricular arrhythmias (SVT) still occur in a significant number of patients with implantable cardioverter defibrillators (ICD). This makes the discovery of novel discriminators that use existing ICD hardware, an attractive proposition. OBJECTIVE: We hypothesised that the delay of activation onset from the device detected, far field electrogram(EGM) to the near field, bipole EGM would allow differentiation of ventricular tachycardias (VT) from SVTs...
December 12, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29245323/lung-adenocarcinoma-and-pulmonary-metastases-coexist-in-a-patient-with-papillary-thyroid-carcinoma-a-case-report
#5
Changhai Cheng, Jinxin Zhou, Xiaonan Shao
RATIONALE: Multiple primary malignant tumors (MPMTs) are defined as 2 or more independent primary malignancies of different histologies/origins in the same individual. Although the incidence of MPMTs is being increasing, second primary cancer (SPC) is still rare and difficult to distinguish from metastasis. Here, we present a case of thyroid carcinoma with lung metastasis and primary lung cancer. PATIENTS CONCERNS: The patient was a 66-year-old man diagnosed of papillary thyroid carcinoma (PTC) with lymph nodes, lung, and skeletons metastases...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29242746/a-practical-method-of-i-131-thyroid-cancer-therapy-dose-optimization-using-estimated-effective-renal-clearance
#6
Brandon A Howard, Olga G James, Jennifer M Perkins, Robert A Pagnanelli, Salvador Borges-Neto, Robert E Reiman
In thyroid cancer patients with renal impairment or other complicating factors, it is important to maximize I-131 therapy efficacy while minimizing bone marrow and lung damage. We developed a web-based calculator based on a modified Benua and Leeper method to calculate the maximum I-131 dose to reduce the risk of these toxicities, based on the effective renal clearance of I-123 as measured from two whole-body I-123 scans, performed at 0 and 24 h post-administration.
2017: SAGE Open Medical Case Reports
https://www.readbyqxmd.com/read/29190950/therapeutic-response-and-long-term-outcome-of-differentiated-thyroid-cancer-with-pulmonary-metastases-treated-by-radioiodine-therapy
#7
Jing Yang, Meng Liang, Yingying Jia, Li Wang, Lin Lin, Jianhua Geng, Shengzu Chen, Ye-Xiong Li, Rong Zheng
Objective: To explore the therapeutic response (TR) and long-term outcomes of iodine-131 (I-131) treatment for patients with differentiated thyroid cancer and pulmonary metastases (DTC+PM), as well as the association between the assessment of TR and long-term outcomes. Methods: This retrospective study comprised 151 DTC+PM patients. TR was evaluated by changes in serum levels of thyroglobulin, anatomic imaging and iodine uptake in pulmonary nodules; logistic regression was applied to identify predictors...
November 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29165912/reproducibility-of-radioactive-iodine-uptake-raiu-measurements
#8
Matthieu Pelletier-Galarneau, Patrick Martineau, Ran Klein, Matthew Henderson, Lionel S Zuckier
BACKGROUND: Measurement of radioactive iodine uptake (RAIU) is an important aspect of the assessment and treatment of patients with hyperthyroidism. Its uncertainty affects how much of a true change in RAIU can be detected as well as appropriateness of the therapy dosage upon which it is based. In this study, a method of estimating the reproducibility and least significant change (LSC) values for RAIU measurements, and the implications of the values observed are discussed, with emphasis on application to quality assurance initiatives...
November 22, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29162424/injectable-hydrogels-for-localized-chemo-and-radio-therapy-in-brain-tumors
#9
Pilar de la Puente, Nicole Fettig, Micah J Luderer, Abbey Jin, Shruti Shah, Barbara Muz, Vaishali Kapoor, Sreekrishna M Goddu, Noha Nabil Salama, Christina Tsien, Dinesh Thotala, Kooresh Shoghi, Buck Rogers, Abdel Kareem Azab
PURPOSE: Overall survival of patients with newly diagnosed glioblastoma (GBM) remains dismal at 16 months with state-of-the-art treatment that includes surgical resection, radiation and chemotherapy. GBM tumors are highly heterogeneous and mechanisms for overcoming tumor resistance have not yet fully been elucidated. An injectable chitosan hydrogel capable of releasing chemotherapy (Temozolomide, TMZ) while retaining radioactive isotopes agents (Iodine, (131)I) was used as a vehicle for localized radiation and chemotherapy, within the surgical cavity...
November 18, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29144545/music-therapy-for-depression
#10
REVIEW
Sonja Aalbers, Laura Fusar-Poli, Ruth E Freeman, Marinus Spreen, Johannes Cf Ket, Annemiek C Vink, Anna Maratos, Mike Crawford, Xi-Jing Chen, Christian Gold
BACKGROUND: Depression is a highly prevalent mood disorder that is characterised by persistent low mood, diminished interest, and loss of pleasure. Music therapy may be helpful in modulating moods and emotions. An update of the 2008 Cochrane review was needed to improve knowledge on effects of music therapy for depression. OBJECTIVES: 1. To assess effects of music therapy for depression in people of any age compared with treatment as usual (TAU) and psychological, pharmacological, and/or other therapies...
November 16, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29142854/skin-metastasis-on-the-neck-an-unusual-presentation-of-recurrence-of-papillary-thyroid-carcinoma
#11
Selen Soylu, Akif Enes Arikan, Serkan Teksoz, Murat Ozcan, Yusuf Bukey
Skin metastasis of papillary thyroid carcinoma (PTC) is rare. Here, two cases of skin metastases of PTC are presented. Both of the patients were females, one is 83 and the other is 65 years old. The patients were admitted to the hospital with a movable skin lesion on anterior neck region. Free T3 and T4 levels were in normal levels and TSH levels were low in both patients. The 83-year-old patient underwent total thyroidectomy due to papillary thyroid cancer and received (131)I ablation therapy and then thyroid suppression therapy...
October 2017: Gland Surgery
https://www.readbyqxmd.com/read/29139105/preoperative-medical-therapy-before-surgery-for-uterine-fibroids
#12
REVIEW
Anne Lethaby, Lucian Puscasiu, Beverley Vollenhoven
BACKGROUND: Uterine fibroids occur in up to 40% of women aged over 35 years. Some are asymptomatic, but up to 50% cause symptoms that warrant therapy. Symptoms include anaemia caused by heavy menstrual bleeding, pelvic pain, dysmenorrhoea, infertility and low quality of life. Surgery is the first choice of treatment. In recent years, medical therapies have been used before surgery to improve intraoperative and postoperative outcomes. However, such therapies tend to be expensive.Fibroid growth is stimulated by oestrogen...
November 15, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29136675/only-a-rapid-complete-biochemical-remission-after-131i-therapy-is-associated-with-an-unimpaired-life-expectancy-in-differentiated-thyroid-cancer
#13
Frederik A Verburg, Uwe Mäder, Inge Grelle, Luca Giovanella, Christoph Reiners, Heribert Hänscheid
The objective of the work was to investigate the relationship between thyroglobulin doubling time (TgDT) as a marker of speed of response to (131)I-therapy and the differentiated thyroid cancer (DTC) recurrence rate, DTC specific mortality rate, and relative survival rate in a DTC population followed over a long period of time after (131)I-therapy. From our database, data of 1354 patients were reviewed. TgDT could be calculated in 174 patients, however, 376 patients did not have sufficient Tg values available for TgDT calculation and 804 patients reached biochemical remission before a sufficient number of Tg measurements for TgDT calculation was acquired...
November 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/29136341/photodynamic-therapy-and-nuclear-imaging-activities-of-zinc-phthalocyanine-integrated-tio2-nanoparticles-in-breast-and-cervical-tumors
#14
Fatma Yurt, Kasim Ocakoglu, Mine Ince, Suleyman Gokhan Colak, Ozge Er, Hale Melis Soylu, Cumhur Gunduz, Cıgır Biray Avci, Cansu Caliskan Kurt
In recent years, phthalocyanines (Pcs) have been widely used as photosensitizer in photodynamic therapy applications. Because of their strong absorptions in the near-infrared region (640-700 nm). The integration of phthalocyanine derivatives to a nanoparticle is expected to be efficient way to improve the activity of the photosensitizer on the targeted tissue. It is known that the integrated molecules not only show better accumulation on tumor tissue but also reduce toxicity in healthy tissues. In this study, the ZnPc molecule was synthesized and integrated to the TiO2 nanoparticle, to investigate the potential of PDT and its cytotoxicity...
November 14, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/29135721/clinical-outcomes-and-prognostic-factors-of-radioiodine-ablation-therapy-for-lymph-node-metastases-from-papillary-thyroid-carcinoma
#15
Xinyu Wu, Hao Gu, Yongju Gao, Bo Li, Ruitai Fan
OBJECTIVE: A total of 118 patients with papillary thyroid carcinoma treated with radioactive iodine for lymph node metastases were analyzed retrospectively between August 2008 and June 2014. We describe the clinical course of these patients and focus on factors associated with lymph node metastases response to iodine-131 (I) treatment. PATIENTS AND METHODS: A total of 118 postoperative papillary thyroid carcinoma patients who underwent I treatment with lymph nodes as the only site of metastasis on whole-body scan (I Rx-WBS) and single-photon emission computed tomography-computed tomography (SPECT-CT) were enrolled...
November 10, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29132255/selected-radiation-safety-aspects-including-transportation-and-lodging-after-outpatient-sup-131-sup-i-therapy-for-differentiated-thyroid-cancer
#16
Cristiane Jeyce Gomes-Lima, Di Wu, Pejman H Kharazi, Gauri Khorjekar, Matthew D Ringel, Richard J Vetter, Gary Bloom, Kenneth D Burman, Leonard Wartofsky, Douglas Van Nostrand
BACKGROUND: Whether <sup>131</sup>I treatments for differentiated thyroid cancer (DTC) should be performed as an outpatient or inpatient remains controversial. The objective of this study was to survey selected aspects of radiation safety of patients treated with <sup>131</sup>I for DTC as an outpatient. METHODS: An e-mail invitation was sent to over 15,000 members of ThyCa: Thyroid Cancer Survivors' Association, Inc. to complete a web-based survey on selected aspects of radiation safety regarding their last outpatient <sup>131</sup>I treatment...
November 13, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29114605/diffuse-large-b-cell-lymphoma-in-very-elderly-patients-over-80-years-old-incorporating-consolidative-radiation-therapy-into-management-decisions
#17
Chelsea C Pinnix, Therese Y Andraos, Bouthaina Dabaja, Sarah Milgrom, Grace Smith, Dai Chihara, Andrea Ng, Luis E Fayad, Yasuhiro Oki, Sattva Neelapu, Jason Westin, M Alma Rodriguez, Loretta J Nastoupil
Purpose: The population of patients aged 80 years or older who are diagnosed with diffuse large B-cell lymphoma (DLBCL) continues to increase, but an optimal treatment strategy has not been established. We sought to examine the influence of consolidative radiation therapy (RT) on outcome and toxicity among the very elderly diagnosed with stage I-IV DLBCL. Methods and materials: We evaluated 131 patients treated at a single institution between 2002 and 2014 who were eligible for RT after successful treatment with chemotherapy...
July 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29113356/prediction-of-thyroidal-131-i-effective-half-life-in-patients-with-graves-disease
#18
Ruiguo Zhang, Guizhi Zhang, Renfei Wang, Jian Tan, Yajing He, Zhaowei Meng
Purpose: Calculation of effective thyroidal half-life (Teff) of iodine-131((131)I) is cumbersome and tedious. The aim of this study was to investigate factors that could be used to predict Teff and to develop a Teff prediction model in Graves' disease patients. Methods: A total of 256 patients with GD were involved in this study. We investigated the influences of age, gender, disease duration, thyroid weight, antithyroid drugs, antithyroid drugs discontinuation period (ADP), thyroid function indexes, thyroid autoantibodies, thyroid-stimulating hormone receptor antibody (TRAb) level and radioactive iodine uptake (RAIU) values before (131)I therapy on Teff, applying univariate and multivariate analyses...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29099942/phase-1-study-of-high-specific-activity-i-131-mibg-for-metastatic-and-or-recurrent-pheochromocytoma-or-paraganglioma
#19
Richard B Noto, Daniel A Pryma, Jessica Jensen, Tess Lin, Nancy Stambler, Thomas Strack, Vivien Wong, Stanley J Goldsmith
Context: There are no approved therapies for the treatment of metastatic and/or recurrent pheochromocytoma or paraganglioma (PPGL) in the United States. Objective: To determine the maximum tolerated dose (MTD) of high-specific-activity I-131 meta-iodobenzylguanidine (MIBG) for the treatment of metastatic and/or recurrent PPGL. Design: Phase 1, dose escalating study to determine the MTD via a standard 3+3 design; escalating by 37 MBq/kg starting at 222 MBq/kg...
November 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29098485/idac-dose-2-1-an-internal-dosimetry-program-for-diagnostic-nuclear-medicine-based-on-the-icrp-adult-reference-voxel-phantoms
#20
Martin Andersson, Lennart Johansson, Keith Eckerman, Sören Mattsson
BACKGROUND: To date, the estimated radiation-absorbed dose to organs and tissues in patients undergoing diagnostic examinations in nuclear medicine is derived via calculations based on models of the human body and the biokinetic behaviour of the radiopharmaceutical. An internal dosimetry computer program, IDAC-Dose2.1, was developed based on the International Commission on Radiological Protection (ICRP)-specific absorbed fractions and computational framework of internal dose assessment given for reference adults in ICRP Publication 133...
November 3, 2017: EJNMMI Research
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