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I-131 Therapy

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https://www.readbyqxmd.com/read/28217014/antithyroglobulin-antibody-as-a-marker-of-successful-ablation-therapy-in-differentiated-thyroid-cancer
#1
Ayu Rosemeilia Dewi, Budi Darmawan, Achmad Hussein Sundawa Kartamihadja, Basuki Hidayat, Johan S Masjhur
The aim of this study was to determine the role of antithyroglobulin antibody (ATA) serum as a marker of successful I-131 ablation therapy in differentiated thyroid cancer (DTC) patients with low serum thyroglobulin (Tg). A retrospective study was conducted on 60 patients (10 males and 50 females). All patients underwent posttotal thyroidectomy and received 2.96 to 3 GBq I-131 ablation. Subjects were divided into two groups with succesful and unsuccessful I-131 ablation therapies. The data of age, gender, histopathologic type, tumor size, and metastasis were collected...
January 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28217013/contributions-to-the-study-of-blood-brain-flux-using-radioactive-tracers
#2
Ioan Mureşan, Ioan Cosma
In this paper, we present an original radiocirculographic method for investigates of cerebral blood flow, which has proven to be very useful, simple, and efficient for studies of brain hemodynamics. Physical considerations on injected radioactive tracer in cardiovascular system, allowed us to state a relationship for the blood flux, F, valued as the amount of fluid-blood that traverses a vascular segment in unit time. All these theoretical facts, along with a host of remarkable clinical results, are presented in a doctoral thesis entitled "The cerebral Hemodynamics in Essential Hypertension and Arteriosclerosis" of the eminent doctor Ioan Mures,an, who died in 1984, at only 50 years old...
January 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28215398/incidental-finding-of-131-i-uptake-in-mesenteric-cystic-lymphangioma-on-post-therapy-131-i-spect-ct-imaging
#3
G Shao, Y Zhao, J Song, S Li
No abstract text is available yet for this article.
February 10, 2017: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/28210770/the-reset-button-revisited-why-high-activity-131-i-therapy-of-advanced-differentiated-thyroid-cancer-after-dosimetry-is-advantageous-for-patients
#4
EDITORIAL
Frederik A Verburg, Markus Luster, Luca Giovanella, Michael Lassmann, Carlo Chiesa, Nicolas Chouin, Glenn Flux
No abstract text is available yet for this article.
February 16, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28209908/prescribed-activities-of-i-131-therapies-in-differentiated-thyroid-cancer-invited-commentary
#5
Douglas Van Nostrand
No abstract text is available yet for this article.
February 16, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28166370/peptide-receptor-radionuclide-treatment-and-131-i-mibg-in-the-management-of-patients-with-metastatic-progressive-phaeochromocytomas-and-paragangliomas
#6
Konstantinos Nastos, Vincent T F Cheung, Christos Toumpanakis, Shaunak Navalkissoor, Anne-Marie Quigley, Martyn Caplin, Bernard Khoo
BACKGROUND AND OBJECTIVES: Radionuclide therapy has been used to treat patients with progressive/metastatic paragangliomas (PGLs) and phaeochromocytomas (PCCs). The aim of the present study is to retrospectively compare the therapeutic outcomes of these modalities in patients with progressive/metastatic PCCs and PGLs. METHODS: Patients with progressive/metastatic PGLs and PCCs that were subjected to radionuclide treatment in our department were retrieved from our department's database for the period 1998-2013...
February 6, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28160320/utility-of-i-124-pet-ct-in-identifying-radioiodine-avid-lesions-in-differentiated-thyroid-cancer-a-systematic-review-and-meta-analysis
#7
REVIEW
Prasanna Santhanam, David Taieb, Lilja Solnes, Wael Marashdeh, Paul W Ladenson
INTRODUCTION: Diagnostic I-123 scans have been shown to underestimate the disease burden in differentiated thyroid cancer (DTC) when compared to I-131 post treatment scans, especially in children and patients who have had prior Radioiodine (RAI) therapy and/or distant metastasis.I-124 PET/CT has been shown to be highly effective in imaging DTC related metastatic disease. METHODS: We performed a systematic review and meta-analysis of studies investigating the sensitivity and specificity of I-124 PET/CT in identifying lesions amenable to RAI therapy as confirmed by I-131 post-treatment scanning...
February 3, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28133242/-effectiveness-of-lenvatinib-for-thyroid-cancer-with-lung-metastases-report-of-a-case
#8
Saki Nagashima, Sadanori Matsuo, Mayumi Takahashi, Yasuko Umemoto, Tomohiro Hirano, Katsuhisa Enomoto, Kenichi Sakurai, Sadao Amano
A 73-year-old woman visited our hospital 1 year 4 months ago because of multiple lung masses that were incidentally detected on CT. We subsequently conducted a whole body examination. Ultrasonography revealed multiple masses in her thyroid. We performed fine needle aspiration biopsy cytology(ABC), and the cytological diagnosis was papillary carcinoma. Total thyroidectomy and modified radical neck dissection were performed. Two months after the operation, cervical lymph nodes were enlarged, and she received I -131 radioisotope therapy...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28128645/development-of-semiautomated-module-for-preparation-of-131-i-labeled-lipiodol-for-liver-cancer-therapy
#9
Archana Mukherjee, Suresh Subramanian, Rajwardhan Ambade, Bhaurao Avhad, Ashutosh Dash, Aruna Korde
Intra-arterial injection of (131)I Lipiodol is an effective treatment option for primary hepatocellular carcinoma as it delivers high radiation dose to liver tumor tissue with minimal accumulation in adjacent normal tissue. The present article demonstrates design, fabrication, and utilization of a semiautomated radiosynthesis module for preparation of (131)I labeled Lipiodol. The radiolabeling method was standardized for preparation of patient dose of (131)I labeled Lipiodol radiochemical yield (RCY); radiochemical purity (RCP) and pharmaceutical purity of the product were determined using optimized procedures...
February 2017: Cancer Biotherapy & Radiopharmaceuticals
https://www.readbyqxmd.com/read/28104741/recombinant-human-thyroid-stimulating-hormone-versus-thyroid-hormone-withdrawal-in-124i-pet-ct-based-dosimetry-for-131i-therapy-of-metastatic-differentiated-thyroid-cancer
#10
Donika Plyku, Robert F Hobbs, Kevin Huang, Frank Atkins, Carlos Garcia, George Sgouros, Douglas Van Nostrand
PURPOSE: Patients with metastatic differentiated thyroid cancer (DTC) may be prepared using either thyroid stimulating hormone withdrawal (THW) or recombinant human thyroid-stimulating hormone (rhTSH) injections prior to (131)I administration for treatment. The objective of this study was to compare the absorbed dose (D) to the critical organs and tumors determined by (124)I-Positron Emission Tomography/Computed Tomography (PET/CT) based dosimetry for (131)I therapy of metastatic DTC when the same patient was prepared with and imaged after both THW and rhTSH injections...
January 19, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28101491/can-the-american-thyroid-association-risk-of-recurrence-predict-radioiodine-refractory-disease-in-differentiated-thyroid-cancer
#11
Aamna Hassan, Saima Riaz, Humayun Bashir, M Khalid Nawaz, Raza Hussain
OBJECTIVE: The aim of this study was to compare the TNM staging system and the American Thyroid Association (ATA) recurrence risk classification in predicting radioiodine refractory disease (RRD) in differentiated thyroid cancer (DTC) and to analyze the correlation of stimulated thyroglobulin (Tg) levels and rate of Tg elevation with the standardized uptake value on (18)F-fludeoxyglucose (FDG) PET/CT scan. METHODS: RRD was indicated through the retrospective analysis of consecutive (18)F-FDG PET/CT scans in DTC with stimulated Tg >10 ng/ml and negative (131)I NaI whole-body scans (WBS)...
December 2016: European Thyroid Journal
https://www.readbyqxmd.com/read/28101490/periodic-granulocyte-count-measuring-is-useful-for-detecting-asymptomatic-agranulocytosis-in-antithyroid-drug-treated-patients-with-graves-disease
#12
Hirotoshi Nakamura, Akane Ide, Takumi Kudo, Eijun Nishihara, Mitsuru Ito, Akira Miyauchi
OBJECTIVE: Finding agranulocytosis (AG) at an early stage is important to improve outcome, but periodic granulocyte count monitoring is not generally recommended for patients with Graves' disease, because AG develops suddenly. METHOD: At the Kuma Hospital, Graves' patients under antithyroid drug (ATD) treatment in an outpatient clinic have a granulocyte count examination during each visit, and if it is <1,000/μl, a warning is immediately sent to the patient's physician...
December 2016: European Thyroid Journal
https://www.readbyqxmd.com/read/28076656/combined-inhaled-beta-agonist-and-anticholinergic-agents-for-emergency-management-in-adults-with-asthma
#13
REVIEW
Scott W Kirkland, Christine Vandenberghe, Britt Voaklander, Taylor Nikel, Sandra Campbell, Brian H Rowe
BACKGROUND: Inhaled short-acting anticholinergics (SAAC) and short-acting beta₂-agonists (SABA) are effective therapies for adult patients with acute asthma who present to the emergency department (ED). It is unclear, however, whether the combination of SAAC and SABA treatment is more effective in reducing hospitalisations compared to treatment with SABA alone. OBJECTIVES: To conduct an up-to-date systematic search and meta-analysis on the effectiveness of combined inhaled therapy (SAAC + SABA agents) vs...
January 11, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28068480/magnetic-resonance-imaging-characterization-and-clinical-outcomes-after-neocart-surgical-therapy-as-a-primary-reparative-treatment-for-knee-cartilage-injuries
#14
Devon E Anderson, Riley J Williams, Thomas M DeBerardino, Dean C Taylor, C Benjamin Ma, Marie S Kane, Dennis C Crawford
BACKGROUND: Autologous cartilage tissue implants, including the NeoCart implant, are intended to repair focal articular cartilage lesions. Short-term results from United States Food and Drug Administration (FDA) phase I and phase II clinical trials indicated that the NeoCart implant was safe when surgically applied as a cell-based therapy and efficacious compared with microfracture. HYPOTHESIS: Quantitative magnetic resonance imaging (MRI) analysis would reveal NeoCart tissue maturation through to 60-month follow-up...
January 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28054519/radioiodine-as-an-adjuvant-therapy-and-its-role-in-follow-up-of-differentiated-thyroid-cancer
#15
REVIEW
S Padma, P Shanmuga Sundaram
Papillary and follicular cancers of thyroid are the most common varieties of differentiated thyroid cancers exhibiting excellent long-term prognosis when carefully managed. Being a slow-growing malignancy, guidelines exist on the staging, preoperative risk stratification, and management of these cancers to increase the overall survival of these patients. Radioactive iodine has a central role in differentiated thyroid malignancies. It has the same physical properties as stable iodine, thus both normal and malignant thyrocytes cannot differentiate radioactive from stable iodine...
July 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28052685/occurrence-of-malignancies-after-kidney-transplantation-in-adults-slovak-multicenter-experience
#16
Z Zilinska, M Sersenova, M Chrastina, J Breza Sr, L Bena, T Baltesova, A Jurcina, R Roland, E Lackova, M Cellar, L Laca, I Dedinska
Malignancies are one of the three major causes of renal recipient´s death with a functioning graft after cardiovascular diseases and infections. Among the variety of risk factors, including conventional and specific to transplant recipients, the duration of immunosuppressive therapy, the intensity of therapy, and the type of immunosuppressive agent all have an impact on development of post-transplant malignancy. The aim of our retrospective study was to document the incidence, the type of malignancies, the patient/graft survival in the group of kidney transplant recipients in Slovak Republic, and to identify the factors which influenced the outcome...
January 5, 2017: Neoplasma
https://www.readbyqxmd.com/read/28047116/su-g-tep3-08-pre-clinical-radionuclide-therapy-dosimetry-in-several-pediatric-cancer-xenografts
#17
I Marsh, M Otto, J Weichert, D Baiu, B Bednarz
PURPOSE: The focus of this work is to perform Monte Carlo-based dosimetry for several pediatric cancer xenografts in mice treated with a novel radiopharmaceutical (131) I-CLR1404. METHODS: Four mice for each tumor cell line were injected with 8-13 µCi/g of the (124) 124I-CLR1404. PET/CT images of each individual mouse were acquired at 5-6 time points over the span of 96-170 hours post-injection. Following acquisition, the images were co-registered, resampled, rescaled, corrected for partial volume effects (PVE), and masked...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046288/we-de-201-06-impact-of-temporal-image-coregistration-methods-on-3d-internal-dose-calculations-in-targeted-radionuclide-therapy
#18
A Besemer, I Marsh, B Bednarz
PURPOSE: The calculation of 3D internal dose calculations in targeted radionuclide therapy requires the acquisition and temporal coregistration of a serial PET/CT or SPECT/CT images. This work investigates the dosimetric impact of different temporal coregistration methods commonly used for 3D internal dosimetry. METHODS: PET/CT images of four mice were acquired at 1, 24, 48, 72, 96, 144 hrs post-injection of (124) I-CLR1404. The therapeutic (131) I-CLR1404 absorbed dose rate (ADR) was calculated at each time point using a Geant4-based MC dosimetry platform using three temporal image coregistration METHODS: (1) no coregistration (NC), whole body sequential CT-CT affine coregistration (WBAC), and individual sequential ROI-ROI affine coregistration (IRAC)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28033742/assessment-of-achieved-systolic-blood-pressure-in-newly-treated-hypertensive-patients-aged-60-79-years-before-and-after-eighth-joint-national-committee-recommendations
#19
Michael S Kelly, Joseph J Saseen, Joel C Marrs
OBJECTIVE: To determine whether patients who were newly prescribed antihypertensive therapy after the Eighth Joint National Committee (JNC 8) update were treated to a relaxed systolic blood pressure (SBP) goal compared with patients treated before the update. METHODS: A retrospective cohort study approved by the Colorado Multiple Institutional Review Board. Patients aged 60-79 years, without diabetes or chronic kidney disease (CKD), newly treated for hypertension at a University of Colorado primary care clinics were included...
February 2017: Therapeutic Advances in Cardiovascular Disease
https://www.readbyqxmd.com/read/28011394/-131-i-labeled-and-dox-loaded-multifunctional-nanoliposomes-for-radiotherapy-and-chemotherapy-in-brain-gliomas
#20
REVIEW
Jingmei Gao, Lei Fang, Danyang Sun, Yiming Shen, Yiming Hu, Ning Li, Jin Chang, Wei Li, Jian Tan
The codelivery of different therapeutics is a promising option because of its synergetic effects of drugs. In this study, a new combination therapy that used the doxorubicin-loaded and (131)I-labeled nanoliposomes ((131)I-DOX-NL) was proposed to delay tumor growth of gliomas, which are characterized by significant mortality and morbidity. (131)I-DOX-NL was constructed based on bovine serum albumin (BSA)-tailor made hydrophobic maleimide-functionalized poly(ε-caprolactone) (PCL) (Fig. 1) and was evaluated by cellular viability in vitro and by U87 xenograft models in vivo...
December 20, 2016: Brain Research
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