Mustafa Can Güler, Ayhan Tanyeli, Ersen Eraslan, Özgür Çelebi, Demet Çelebi, Selim Çomakli, Emir Enis Yurdgülü, Yasin Bayir
OBJECTIVES: Sepsis poses a significant threat to human life, rendering it a burdensome medical disease. Despite significant advancements, the current state of medical science still lacks a viable and efficacious cure. Costunolide (COST) is a multifaceted sesquiterpene lactone that exhibits a range of actions, including anti-inflammatory and antioxidant properties. We investigated the potential impacts of COST on a rat sepsis model caused by cecal ligation and puncture (CLP). MATERIALS AND METHODS: We created an experimental rat model with the following groups: SHAM, CLP, CLP+low dose COST, and CLP+high dose COST...
2024: Iranian Journal of Basic Medical Sciences