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https://www.readbyqxmd.com/read/28929423/oxidative-stress-in-inflammatory-cells-of-patient-with-rheumatoid-arthritis-clinical-efficacy-of-dietary-antioxidants
#1
REVIEW
Asis Bala, Chaitali Mondal, Pallab Kanti Haldar, Bidita Khandelwal
Rheumatoid arthritis (RA) is an autoimmune disease responsible for significant human morbidity in modern life. However, oxidative stress is one of the key markers for determining pathophysiology of patients with RA. The interaction between cellular immune system and body's endogenous and/or exogenous antigens produce reactive oxygen species (ROS) and reactive nitrogen species (RNS) in autoimmune disease like RA. ROS and RNS include highly toxic superoxide (O2(-)) and peroxynitrite (ONOO(-)) radicals, which activate the signaling cascades of inflammatory cells to synthesize pro-inflammatory cytokines and chemokines...
September 19, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28928030/the-histone-deacetylase-inhibitor-sodium-butyrate-protects-against-noise-induced-hearing-loss-in-guinea-pigs
#2
Deng-Hua Yang, Jing Xie, Ke Liu, Zhe Peng, Jing-Ying Guo, Shu-Kui Yu, Guo-Peng Wang, Shu-Sheng Gong
Noise-induced hearing loss (NIHL) severely impacts the quality of life of affected individuals. Oxidative stress resulting from noise exposure is a significant cause of NIHL. Although histone deacetylase (HDAC) inhibitors were shown to protect against NIHL, the underlying mechanism remains unclear, and it is not known how they act on noise-induced oxidative stress. In the current study, we investigated the expression levels of acetyl-histone H3 (Lys9) (H3-AcK9), histone deacetylase 1 (HDAC1), and 3-nitrotyrosine (3-NT), an oxidative stress marker, in a guinea pig model of NIHL using immunohistology and Western blotting...
September 16, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28927530/an-insight-into-the-genotoxicity-assessment-studies-in-dipterans
#3
REVIEW
Nidhi Mishra, Rashmi Srivastava, Uma Rani Agrawal, Raghav Ram Tewari
The dipterans have been widely utilized in genotoxicity assessment studies. Short life span, easy maintenance, production of large number of offspring in a single generation and the tissues with appropriate cell populations make these flies ideal for studies associated to developmental biology, diseases, genetics, genetic toxicology and stress biology in the group. Moreover, their cosmopolitan presence makes them suitable candidate for ecological bio-monitoring. An attempt has been made in the present review to reveal the significance of dipteran flies for assessing alterations in genetic content through various genotoxicity biomarkers and to summarize the gradual advancement in these studies...
July 2017: Mutation Research
https://www.readbyqxmd.com/read/28926288/effect-of-inpatient-palliative-care-during-hematopoietic-stem-cell-transplant-on-psychological-distress-6-months-after-transplant-results-of-a-randomized-clinical-trial
#4
Areej El-Jawahri, Lara Traeger, Joseph A Greer, Harry VanDusen, Sarah R Fishman, Thomas W LeBlanc, William F Pirl, Vicki A Jackson, Jason Telles, Alison Rhodes, Zhigang Li, Thomas R Spitzer, Steven McAfee, Yi-Bin A Chen, Jennifer S Temel
Purpose Inpatient palliative care integrated with transplant care improves patients' quality of life (QOL) and symptom burden during hematopoietic stem-cell transplant (HCT). We assessed patients' mood, post-traumatic stress disorder (PTSD) symptoms, and QOL 6 months post-transplant. Methods We randomly assigned 160 patients with hematologic malignancies who underwent autologous or allogeneic HCT to inpatient palliative care integrated with transplant care (n = 81) or transplant care alone (n = 79). At baseline and 6 months post-transplant, we assessed mood, PTSD symptoms, and QOL with the Hospital Anxiety and Depression Scale and Patient Health Questionnaire, PTSD checklist, and Functional Assessment of Cancer Therapy-Bone Marrow Transplant...
September 19, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28925498/electronic-diary-for-recording-headaches-triggers-and-medication-use-development-and-evaluation
#5
Siavash Bandarian-Balooch, Paul R Martin, Brenton McNally, Arissa Brunelli, Sharon Mackenzie
OBJECTIVE: To evaluate an e-diary developed for measuring headaches, triggers, and medication consumption, in terms of reliability and validity, and variables such as ease of use and participant compliance. BACKGROUND: For many decades, behavioral treatment of headaches has been evaluated via participants completing paper diaries recording their headaches and associated phenomena. There is some limited evidence supporting the reliability and validity of paper diaries, and criticisms have been offered such as the large amount of effort involved for both participants and researchers...
September 19, 2017: Headache
https://www.readbyqxmd.com/read/28924680/the-oncological-patient-in-the-palliative-situation
#6
Steffen Eychmueller, Diana Zwahlen, Monica Fliedner
Palliative care approaches patients and their suffering with a bio-psycho-social-spiritual model. Thus, it is the strength of palliative care to complement the diagnosis driven approach of medical cancer care by a problem and resources-based assessment, participatory care plan and person-directed interventions. Interventions need to reflect timely prognosis, target population (the patient, the family carer, the professional) and level of trust and remaining energy. In palliative care the relevance of psycho-oncological aspects in the care of the terminally ill is considerable in the understanding of the overall suffering of patients approaching death and their loved ones and in their care and support...
2018: Recent Results in Cancer Research
https://www.readbyqxmd.com/read/28923923/hydrologic-regulation-of-plant-rooting-depth
#7
Ying Fan, Gonzalo Miguez-Macho, Esteban G Jobbágy, Robert B Jackson, Carlos Otero-Casal
Plant rooting depth affects ecosystem resilience to environmental stress such as drought. Deep roots connect deep soil/groundwater to the atmosphere, thus influencing the hydrologic cycle and climate. Deep roots enhance bedrock weathering, thus regulating the long-term carbon cycle. However, we know little about how deep roots go and why. Here, we present a global synthesis of 2,200 root observations of >1,000 species along biotic (life form, genus) and abiotic (precipitation, soil, drainage) gradients. Results reveal strong sensitivities of rooting depth to local soil water profiles determined by precipitation infiltration depth from the top (reflecting climate and soil), and groundwater table depth from below (reflecting topography-driven land drainage)...
September 18, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28922735/assessing-the-interplay-of-childhood-adversities-with-more-recent-stressful-life-events-and-conditions-in-predicting-panic-pathology-among-adults-from-the-general-population
#8
E Asselmann, J Stender, H J Grabe, J König, C O Schmidt, A O Hamm, C A Pané-Farré
BACKGROUND: Although research suggests that (a) childhood adversities and more recent stressful life events/conditions are risk factors for panic pathology and that (b) early life stress increases vulnerability to later psychopathology, it remains unclear whether childhood adversities amplify the association between more recent stressful life events/conditions and panic pathology. METHODS: Data were derived from a general population sample (Study of Health in Pomerania, SHIP)...
August 24, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28920034/the-use-of-intraoperative-transesophageal-echocardiography-in-thoracic-aortic-dissection-due-to-chronic-cocaine-abuse
#9
Ali Dabbagh, Mohammad Kazem Arabnia, Mahnoosh Foroughi, Mehran Shahzamani, Hassan Rahmian
INTRODUCTION: Aortic dissection is a life threatening disease and is usually accompanied by a high rate of mortality and morbidity. Here we present a case report in which intraoperative tranesophageal echocardiography was used for intraoperative assessments of thoracic aortic dissection due to cocaine abuse. CASE PRESENTATION: A 45- year- old male was admitted to a university hospital due to severe chest pain. He was suffering from severe excruciating chest pain that had started after a psychological stress, leading to heavy cocaine abuse...
February 2017: Anesthesiology and Pain Medicine
https://www.readbyqxmd.com/read/28920011/perceived-racial-ethnic-discrimination-and-mental-health-a-review-and-future-directions-for-social-epidemiology
#10
Anissa I Vines, Julia B Ward, Evette Cordoba, Kristin Z Black
PURPOSE OF REVIEW: Recent literature on racial or ethnic discrimination and mental health was reviewed to assess the current science and identify key areas of emphasis for social epidemiology. Objectives of this review were to: 1) Determine whether there have been advancements in the measurement and analysis of perceived discrimination; 2) Identify the use of theories and/or frameworks in perceived discrimination and mental health research; and 3) Assess the extent to which stress buffers are being considered and evaluated in the existing literature...
June 2017: Current Epidemiology Reports
https://www.readbyqxmd.com/read/28919825/abdominal-sacrocolpopexy-with-pelvicol-xenograft-and-concomitant-burch-colposuspension
#11
Sameh Hijazi, Dieter Echtle, Omar M Aboumarzouk, Elmar Heinrich
PURPOSE: To evaluate the efficacy of Pelvicol xenograft use during abdominal sacrocolpopexy to repair pelvic organ prolapse (POP). PATIENTS AND METHODS: A total of 27 consecutive women with symptomatic POP were included in this study. A POP-quantification system and International Continence Society classification were used. Functional and anatomical outcomes were assessed. Subjective outcomes and physical activity after surgery were evaluated due to modified quality of life questionnaire...
2017: International Journal of Women's Health
https://www.readbyqxmd.com/read/28912904/fasciatherapy-and-reflexology-compared-to-hypnosis-and-music-therapy-in-daily-stress-management
#12
Bernard Payrau, Nadine Quere, Elisabeth Breton, Christine Payrau
BACKGROUND: Patients suffering from stress symptoms due to every-day life who are looking for a non-pharmacological response to their relief expectation are many. Furthermore, early reckoning of the day-to-day stress which may lead to clinical diagnosis is the best way of preventing the stress-related diseases. Among the many alternative medicinal options, there is little evidence that fasciatherapy (Fs) and reflexology (Rf) are effective in this field. PURPOSE: assess incidence of fasciatherapy Danis Bois Method (DBM) and of reflexology on patients' stress level in everyday-life, and provide a more informed choice among the numerous mind and body techniques by comparing them with hypnosis (Hp) and music therapy (Mt)...
September 2017: International Journal of Therapeutic Massage & Bodywork
https://www.readbyqxmd.com/read/28911874/childhood-adversity-predicts-reduced-physiological-flexibility-during-the-processing-of-negative-affect-among-adolescents-with-major-depression-histories
#13
Shimrit Daches, Maria Kovacs, Charles George, Ilya Yaroslavsky, Eniko Kiss, Agnes Vetro, Roberta Dochnal, István Benak, Ildikó Baji, Kitti Halas, Attila Makai, Krisztina Kapornai, Jonathan Rottenberg
BACKGROUND: Adversity during early development has been shown to have enduring negative physiological consequences. In turn, atypical physiological functioning has been associated with maladaptive processing of negative affect, including its regulation. The present study therefore explored whether exposure to adverse life events in childhood predicted maladaptive (less flexible) parasympathetic nervous system functioning during the processing of negative affect among adolescents with depression histories...
September 11, 2017: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/28911009/contemporaneous-social-environment-and-the-architecture-of-late-life-gene-expression-profiles
#14
Morgan E Levine, Eileen M Crimmins, David R Weir, Steve W Cole
Environmental or social challenges can stimulate a cascade of coordinated physiological changes in stress response systems. Unfortunately, chronic activation of these adaptations under conditions such as low socioeconomic status (SES) can have negative consequences for long-term health. While there is substantial evidence tying low SES to increased disease risk and reduced life expectancy, the underlying biology remains poorly understood. Using pilot data on 120 older adults from the Health and Retirement Study (United States, 2002-2010), we examined the associations between SES and gene expression levels in adulthood, with particular focus on a gene expression program known as the conserved transcriptional response to adversity...
September 1, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28910603/apolipoprotein-a-iv-constrains-hpa-and-behavioral-stress-responsivity-in-a-strain-dependent-manner
#15
Amy E B Packard, Jintao Zhang, Brent Myers, Chih-Wei Ko, Fei Wang, Patrick Tso, Yvonne M Ulrich-Lai
There is a critical gap in our knowledge of the mechanisms that govern interactions between daily life experiences (e.g., stress) and metabolic diseases, despite evidence that stress can have profound effects on cardiometabolic health. Apolipoprotein A-IV (apoA-IV) is a protein found in chylomicrons (lipoprotein particles that transport lipids throughout the body) where it participates in lipid handling and the regulation of peripheral metabolism. Moreover, apoA-IV is expressed in brain regions that regulate energy balance including the arcuate nucleus...
September 1, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28902948/psychological-health-status-and-health-related-quality-of-life-in-adults-with-atopic-dermatitis-a-nationwide-cross-sectional-study-in-south-korea
#16
Sul Hee Lee, Si Hyung Lee, Sung Yul Lee, Bora Lee, Sang-Hoon Lee, Young Lip Park
Atopic dermatitis (AD) is a chronic inflammatory skin disorder. Patients with AD often experience psychological distress and poor health-related quality of life (HRQoL). The aim of this study was to investigate the association of several psychological health statuses and poor HRQoL in an adult population with AD in South Korea. A total of 38,741 adults who participated in the Korean National Health and Nutrition Examination Survey, a nationwide, population-based, cross-sectional health survey between 2008 and 2013 were included...
September 13, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28900743/catechin-ameliorates-doxorubicin-induced-neuronal-cytotoxicity-in-in-vitro-and-episodic-memory-deficit-in-in-vivo-in-wistar-rats
#17
Sri Pragnya Cheruku, Grandhi Venkata Ramalingayya, Mallikarjuna Rao Chamallamudi, Subhankar Biswas, Krishnadas Nandakumar, Madhavan Nampoothiri, Karthik Gourishetti, Nitesh Kumar
Cognitive dysfunction by chemotherapy compromises the quality of life in cancer patients. Tea polyphenols are known chemopreventive agents. The present study was designed to evaluate the neuroprotective potential of (+) catechin hydrate (catechin), a tea polyphenol, in IMR-32 neuroblastoma cells in vitro and alleviation of episodic memory deficit in Wistar rats in vivo against a widely used chemotherapeutic agent, Doxorubicin (DOX). In vitro, neuroprotective studies were assessed in undifferentiated IMR-32 cells using percentage viability and in differentiated cells by neurite length...
September 13, 2017: Cytotechnology
https://www.readbyqxmd.com/read/28900271/transgenerational-exposure-of-north-atlantic-bivalves-to-ocean-acidification-renders-offspring-more-vulnerable-to-low-ph-and-additional-stressors
#18
Andrew W Griffith, Christopher J Gobler
While early life-stage marine bivalves are vulnerable to ocean acidification, effects over successive generations are poorly characterized. The objective of this work was to assess the transgenerational effects of ocean acidification on two species of North Atlantic bivalve shellfish, Mercenaria mercenaria and Argopecten irradians. Adults of both species were subjected to high and low pCO2 conditions during gametogenesis. Resultant larvae were exposed to low and ambient pH conditions in addition to multiple, additional stressors including thermal stress, food-limitation, and exposure to a harmful alga...
September 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28899586/dissociative-sensibility-disorders-a-retrospective-case-series-and-systematic-literature-review
#19
REVIEW
Peter Weber, Rahel Erlacher
CONTEXT: Dissociative disorders present a huge challenge in clinical settings. In contrast to other dissociative symptoms, dissociative sensibility disorders are rarely focused on. OBJECTIVE: To identify the clinical characteristics and outcomes of dissociative sensibility disorders in children and adolescents, and to review the use of diagnostic procedures. DATA SOURCES: For the review, a literature search used Pubmed, Embase, Web of Science, and PubPsych (to 02/2015) and the reference lists of the studies identified...
September 1, 2017: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/28898774/toxicity-of-naproxen-sodium-and-its-mixture-with-tramadol-hydrochloride-on-fish-early-life-stages
#20
Pavla Sehonova, Lucie Plhalova, Jana Blahova, Veronika Doubkova, Miroslav Prokes, Frantisek Tichy, Emma Fiorino, Caterina Faggio, Zdenka Svobodova
Pharmaceuticals occur in water bodies as a consequence of their incomplete removal during waste water treatment processes. The occurence of pharmaceuticals in surface waters as well as their possible impact on aquatic vertebrates have received considerable attention in recent years. However, there is still a lack of informations on the chronic effects of widely used drugs as well as their possible mixture toxicity on non-target aquatic vertebrates as well as their possible mixture toxicity. The aim of this study was to assess the effects of naproxen sodium on early life stages of fish and evaluate its mixture toxicity with tramadol hydrochloride, which was assessed in our earlier study as a single substance...
August 31, 2017: Chemosphere
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