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https://www.readbyqxmd.com/read/28549268/modulation-of-hpa-axis-response-to-social-stress-in-schizophrenia-by-childhood-trauma
#1
Claudia Lange, Christian G Huber, Daniela Fröhlich, Stefan Borgwardt, Undine E Lang, Marc Walter
HPA axis functioning plays an important role in the etiology of schizophrenia spectrum disorders (SSD). However, only few studies have examined HPA axis responsivity to psychosocial stress in SSD, and results are heterogeneous. Furthermore, childhood trauma is known to influence psychopathology and treatment outcome in SSD, but studies on the influence of childhood trauma on stress related HPA axis activity are missing. The purpose of this study was to investigate cortisol response to a psychosocial stress challenge in SSD patients, and to examine its association with severity of childhood trauma...
May 20, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28547996/predicting-health-related-quality-of-life-in-people-living-with-hiv-in-nepal-mental-health-disorders-and-substance-use-determinants
#2
Khem N Pokhrel, Vidya D Sharma, Akira Shibanuma, Kalpana G Pokhrel, Linda B Mlunde, Masamine Jimba
HIV-positive people often experience mental health disorders and engage in substance use. Such conditions tend to impair their health-related quality of life (QOL). Evidence, however, is limited about the influence of mental health disorders and substance use on QOL by gender. Also, little is known about the influences of anxiety and high levels of stress on QOL. We recruited 682 HIV-positive people in Nepal and measured their depression, anxiety, stress levels, substance use, and QOL. Multiple linear regressions assessed the association of mental health disorders and substance use with QOL...
May 26, 2017: AIDS Care
https://www.readbyqxmd.com/read/28544806/can-soil-microbial-diversity-influence-plant-metabolites-and-life-history-traits-of-a-rhizophagous-insect-a-demonstration-in-oilseed-rape
#3
Tom Lachaise, Morgane Ourry, Lionel Lebreton, Anne-Yvonne Guillerm-Erckelboudt, Juliette Linglin, Chrystelle Paty, Valérie Chaminade, Nathalie Marnet, Julie Aubert, Denis Poinsot, Anne-Marie Cortesero, Christophe Mougel
Interactions between plants and phytophagous insects play an important part in shaping the biochemical composition of plants. Reciprocally plant metabolites can influence major life history traits in these insects and largely contribute to their fitness. Plant rhizospheric microorganisms are an important biotic factor modulating plant metabolites and adaptation to stress. While plant-insects or plant-microorganisms interactions and their consequences on the plant metabolite signature are well-documented, the impact of soil microbial communities on plant defenses against phytophagous insects remains poorly known...
May 23, 2017: Insect Science
https://www.readbyqxmd.com/read/28544158/molecular-and-physiological-manifestations-and-measurement-of-aging-in-humans
#4
REVIEW
Sadiya S Khan, Benjamin D Singer, Douglas E Vaughan
Biological aging is associated with a reduction in the reparative and regenerative potential in tissues and organs. This reduction manifests as a decreased physiological reserve in response to stress (termed homeostenosis) and a time-dependent failure of complex molecular mechanisms that cumulatively create disorder. Aging inevitably occurs with time in all organisms and emerges on a molecular, cellular, organ, and organismal level with genetic, epigenetic, and environmental modulators. Individuals with the same chronological age exhibit differential trajectories of age-related decline, and it follows that we should assess biological age distinctly from chronological age...
May 23, 2017: Aging Cell
https://www.readbyqxmd.com/read/28542424/development-of-behavioural-profile-in-the-northern-common-boa-boa-imperator-repeatable-independent-traits-or-personality
#5
Olga Šimková, Petra Frýdlová, Barbora Žampachová, Daniel Frynta, Eva Landová
Recent studies of animal personality have focused on its proximate causation and ecological and evolutionary significance in particular, but the question of its development was largely overlooked. The attributes of personality are defined as between-individual differences in behaviour, which are consistent over time (differential consistency) and contexts (contextual generality) and both can be affected by development. We assessed several candidates for personality variables measured in various tests with different contexts over several life-stages (juveniles, older juveniles, subadults and adults) in the Northern common boa...
2017: PloS One
https://www.readbyqxmd.com/read/28542264/child-mortality-hypothalamic-pituitary-adrenal-axis-activity-and-cellular-aging-in-mothers
#6
Cindy K Barha, Katrina G Salvante, Courtney W Hanna, Samantha L Wilson, Wendy P Robinson, Rachel M Altman, Pablo A Nepomnaschy
Psychological challenges, including traumatic events, have been hypothesized to increase the age-related pace of biological aging. Here we test the hypothesis that psychological challenges can affect the pace of telomere attrition, a marker of cellular aging, using data from an ongoing longitudinal-cohort study of Kaqchikel Mayan women living in a population with a high frequency of child mortality, a traumatic life event. Specifically, we evaluate the associations between child mortality, maternal telomere length and the mothers' hypothalamic-pituitary-adrenal axis (HPAA), or stress axis, activity...
2017: PloS One
https://www.readbyqxmd.com/read/28541788/addressing-hereditary-cancer-risk-at-the-end-of-life
#7
Eric J Roeland, Alexandra D Dullea, Chelsea H Hagmann, Lisa Madlensky
Oncology guidelines clearly outline evidence-based recommendations for patients with newly diagnosed cancer to help oncologists determine which patients are appropriate for a genetic assessment. Ideally, patients with newly diagnosed cancer, who have personal or family histories suggestive of hereditary cancer predisposition, are referred for genetics work up in the nonurgent setting. However, in some cases, a genetics work up is delayed until the end of life. This is a time of heightened stress and additional obstacles, including discordance between family members regarding the obtainment of genetic information, paying for testing, selecting a surrogate to receive and disperse information in the case of a patient's death, and the use of DNA banking for future evaluation...
May 25, 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/28541762/chronic-stress-exposure-and-generation-are-related-to-the-p-factor-and-externalizing-specific-psychopathology-in-youth
#8
Hannah R Snyder, Jami F Young, Benjamin L Hankin
Psychopathology is posited to be transdiagnostically linked to chronic stress. Yet efforts to understand the specificity and directionality of these links have been sparse, and the ubiquitous comorbidity of psychopathology has made the seemingly nonspecific links between psychological disorders and chronic stress difficult to interpret. The current study used a latent dimensional bifactor model of psychopathology to account for comorbidity and a multiwave prospective design to disentangle temporal associations between psychopathology and chronic stress longitudinally during the critical adolescent period for psychopathology risk and stress reactivity...
May 25, 2017: Journal of Clinical Child and Adolescent Psychology
https://www.readbyqxmd.com/read/28541073/symptoms-of-stress-and-depression-effect-percentage-of-body-fat-and-insulin-resistance-in-healthy-youth-look-longitudinal-study
#9
Lisa S Olive, Rohan M Telford, D G Byrne, Walter P Abhayaratna, Richard D Telford
OBJECTIVE: This study examined the longitudinal and cross-sectional effects of both psychosocial stress and depressive symptoms on insulin resistance and percentage body fat in a cohort of healthy Australian children, following them from childhood into adolescence. METHOD: Participants were 791 healthy, initially Grade 2 children (7-8 years; 394 girls), selected from the general community. Psychosocial stress was assessed using the Children's Stress Questionnaire, while depressive symptoms were assessed using the Children's Depression Inventory...
May 25, 2017: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
https://www.readbyqxmd.com/read/28541065/frontal-alpha-asymmetry-in-ocd-patients-and-unaffected-first-degree-relatives
#10
Rosa Grützmann, Anja Riesel, Julia Klawohn, Stephan Heinzel, Christian Kaufmann, Katharina Bey, Leonard Lennertz, Michael Wagner, Norbert Kathmann
Frontal electroencephalographic alpha asymmetry as an indicator of trait approach and trait inhibition systems has previously been studied in individuals with obsessive-compulsive disorder (OCD) with mixed results. We explored frontal alpha asymmetry as a possible risk factor in OCD by investigating a large sample of OCD patients (n = 113), healthy control participants (n = 113), and unaffected 1st-degree relatives of OCD patients (n = 37). Additionally, the relationship between OCD symptom dimensions and frontal alpha asymmetry was explored...
May 25, 2017: Journal of Abnormal Psychology
https://www.readbyqxmd.com/read/28540348/psychobiological-responses-to-critically-evaluated-multitasking
#11
Mark A Wetherell, Olivia Craw, Kenny Smith, Michael A Smith
In order to understand psychobiological responses to stress it is necessary to observe how people react to controlled stressors. A range of stressors exist for this purpose; however, laboratory stressors that are representative of real life situations provide more ecologically valid opportunities for assessing stress responding. The current study assessed psychobiological responses to an ecologically valid laboratory stressor involving multitasking and critical evaluation. The stressor elicited significant increases in psychological and cardiovascular stress reactivity; however, no cortisol reactivity was observed...
December 2017: Neurobiology of Stress
https://www.readbyqxmd.com/read/28539538/exhausting-physicians-employed-in-hospitals-in-japan-assessed-by-a-health-questionnaire
#12
Shosuke Suzuki
OBJECTIVE: Japanese physicians employed and working in general hospitals have become busier since 2005, as they had to teach and guide the increased number of medical residents graduated from medical schools. Working hours and chronic fatigue of employed physicians were surveyed compared with independent physicians working in their own out-patient clinics and with usual employed men in Japan, and their mental health was assessed. METHODS: (1) 75 employed physicians in hospitals were surveyed of their working hours a week and compared with (2) 48 independent general practitioners (GP) who work in their own out-patient clinics...
May 25, 2017: Sangyō Eiseigaku Zasshi, Journal of Occupational Health
https://www.readbyqxmd.com/read/28539089/simulating-real-life-exposures-to-uncover-possible-risks-to-human-health-a-proposed-consensus-for-a-novel-methodological-approach
#13
A M Tsatsakis, D Kouretas, M N Tzatzarakis, P Stivaktakis, K Tsarouhas, K S Golokhvast, V N Rakitskii, V A Tutelyan, A F Hernandez, R Rezaee, G Chung, C Fenga, A B Engin, M Neagu, A L Arsene, A O Docea, E Gofita, D Calina, I Taitzoglou, J Liesivuori, A W Hayes, S Gutnikov, C Tsitsimpikou
In real life, consumers are exposed to complex mixtures of chemicals via food, water and commercial products consumption. Since risk assessment usually focuses on individual compounds, the current regulatory approach doesn't assess the overall risk of chemicals present in a mixture. This study will evaluate the cumulative toxicity of mixtures of different classes of pesticides and mixtures of different classes of pesticides together with food additives (FAs) and common consumer product chemicals using realistic doses after long-term exposure...
June 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/28537422/mindfulness-based-stress-reduction-program-on-chronic-low-back-pain-a-study-investigating-the-impact-on-endocrine-physical-and-psychologic-functioning
#14
Rita B Ardito, Piero Stanley Pirro, Tania S Re, Isabella Bonapace, Valentino Menardo, Emanuela Bruno, Laura Gianotti
OBJECTIVE: To explore the impact of the Mindfulness-Based Stress Reduction (MBSR) program on pain severity and endocrine, physical, and psychologic functioning in patients with chronic low-back pain (CLBP). METHODS: A total of 28 participants were enrolled in the study between January and June 2014; 17 participants were sequentially sampled for an 8-week MBSR program, and 11 were placed on a waitlist control group. Pain severity, quality of life (QOL), global psychologic functioning, and depression were assessed at baseline, at the end of treatment, and 4-5 months post-treatment for both groups...
May 24, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28536989/development-and-evaluation-of-an-online-mental-health-program-for-medical-students
#15
Emily G Lattie, Jennifer L Duffecy, David C Mohr, Kathleen Kashima
OBJECTIVE: Medical school presents a time of psychological distress for many students, who are less likely than the general population to seek mental health treatment due to multiple treatment barriers. Internet-based cognitive behavioral therapy (iCBT) programs may be an acceptable option for medical students. This study aims to assess acceptability and usability of ThinkFeelDo, an iCBT program, and to examine the impact of the program on perceived stress, quality of life, and the development of cognitive and behavioral coping skills...
May 23, 2017: Academic Psychiatry
https://www.readbyqxmd.com/read/28535425/prenatal-ambient-air-pollution-exposure-infant-growth-and-placental-mitochondrial-dna-content-in-the-inma-birth-cohort
#16
Diana B P Clemente, Maribel Casas, Bram G Janssen, Aitana Lertxundi, Loreto Santa-Marina, Carmen Iñiguez, Sabrina Llop, Jordi Sunyer, Mònica Guxens, Tim S Nawrot, Martine Vrijheid
BACKGROUND: The association between prenatal air pollution exposure and postnatal growth has hardly been explored. Mitochondrial DNA (mtDNA), as a marker of oxidative stress, and growth at birth can play an intermediate role in this association. OBJECTIVE: In a subset of the Spanish birth cohort INMA we assessed first whether prenatal nitrogen dioxide (NO2) exposure is associated with infant growth. Secondly, we evaluated whether growth at birth (length and weight) could play a mediating role in this association...
May 20, 2017: Environmental Research
https://www.readbyqxmd.com/read/28534094/lifetime-traumatic-events-health-related-quality-of-life-and-satisfaction-with-life-in-older-adults
#17
Catherine Lamoureux-Lamarche, Helen-Maria Vasiliadis
PURPOSES: The aims were to assess the association between lifetime traumatic events and post-traumatic stress syndrome (PTSS) and health-related quality of life (HRQOL) and satisfaction with life stratified by gender among a community-dwelling sample of older adults. METHODS: Data used came from the ESA-Services study (2011-2013) and included a large convenience sample of 1811 older adults. Traumatic events were measured using a list of 14 events. PTSS was measured using the Impact of Event Scale-Revised...
May 22, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28533746/intraoperative-frontal-alpha-band-power-correlates-with-preoperative-neurocognitive-function-in-older-adults
#18
Charles M Giattino, Jacob E Gardner, Faris M Sbahi, Kenneth C Roberts, Mary Cooter, Eugene Moretti, Jeffrey N Browndyke, Joseph P Mathew, Marty G Woldorff, Miles Berger
Each year over 16 million older Americans undergo general anesthesia for surgery, and up to 40% develop postoperative delirium and/or cognitive dysfunction (POCD). Delirium and POCD are each associated with decreased quality of life, early retirement, increased 1-year mortality, and long-term cognitive decline. Multiple investigators have thus suggested that anesthesia and surgery place severe stress on the aging brain, and that patients with less ability to withstand this stress will be at increased risk for developing postoperative delirium and POCD...
2017: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/28532277/temporal-parameters-of-post-stress-prophylactic-glucose-treatment-in-rats
#19
M A Conoscenti, E E Hart, N J Smith, T R Minor
Acute trauma can lead to life-long changes in susceptibility to psychiatric disease, such as Post-Traumatic Stress Disorder (PTSD). Rats given free access to a concentrated glucose solution for 24 hours beginning immediately after trauma failed to show stress-related pathology in the learned helplessness model of PTSD and comorbid major depression. We assessed effective dosing and temporal constraints of the glucose intervention in three experiments. We exposed 120 male Sprague-Dawley rats to 100, 1 mA, 3-15s, inescapable and unpredictable electric tail shocks (over a 110 minute period) or simple restraint in the learned helplessness procedure...
May 22, 2017: Stress: the International Journal on the Biology of Stress
https://www.readbyqxmd.com/read/28530432/posttraumatic-stress-symptom-severity-and-health-service-utilization-in-trauma-exposed-parents
#20
Emma J Thompson, Vicki A Anderson, Stephen J C Hearps, Maria C McCarthy, Cathrine Mihalopoulos, Jan M Nicholson, Meredith Rayner, Frank Muscara
OBJECTIVE: Posttraumatic stress disorder (PTSD) and posttraumatic stress symptoms (PTSSs) are common for parents of children with life-threatening illnesses or injuries. The impact of these psychological sequelae on parents' personal use of health services is unknown. The present study aimed to investigate whether PTSS severity prospectively predicts increased health service utilization (HSU), and to examine the relative importance of other predisposing and enabling factors in predicting HSU...
May 22, 2017: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
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