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https://www.readbyqxmd.com/read/27535492/intraoperative-management-and-early-postoperative-outcomes-of-pediatric-renal-transplants
#1
Katherine Taylor, Wooheon Thomas Kim, Malak Maharramova, Victor Figueroa, Smruthi Ramesh, Armando Lorenzo
INTRODUCTION: Smaller children are presenting for renal transplantation as the treatment of choice for end-stage renal disease. Adult donor organs are more successful than pediatric deceased donor organs. An adult kidney may sequester ~75% of the circulating volume of a 5 year-old child and requires significantly increased cardiac output to maintain renal perfusion. Treatment includes volume, inotropic or vasopressor agents, or central neuroaxial blockade for sympatholysis. We describe the perioperative anesthestic management as a guide to clinical outcomes...
October 2016: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/27032708/massive-transfusion-of-5-u-packed-redblood-cells-3-u-fresh-frozen-plasma-and-160-cc-of-platelets-in-a-14-month-old-patient
#2
Tanaya Sparkle, Staci Cameron
BACKGROUND: We present a case in which extremely rapid massive transfusion was successfully used to combat severe acute bleeding during a parietooccipital tumor resection in a 14-month-old patient. CASE REPORT: An 8-kg patient was found to have a 4 × 5 × 5-cm parietooccipital tumor on computed tomography scan, for which resection was urgently planned. Sudden acute bleeding was encountered, which was communicated to the anesthesia team. Transfusion was initiated and a total of 5 units of packed red blood cells, 3 units of fresh frozen plasma, 160 ml of platelets, 200 ml of albumin, and 500 ml of 0...
2016: American Journal of Case Reports
https://www.readbyqxmd.com/read/26648986/the-pharmacological-protection-of-renal-function-in-patients-undergoing-cardiac-surgery
#3
Emine Bilge Narin, Ilhan Oztekin, SeherDeniz Oztekin, Betul Ogutmen
OBJECTIVES: To compare the effects of different routes and timings of administration of dopamine and mannitol used to alleviate the adverse effects of prolonged cardiopulmonary bypass (CPB) on renal functions in coronary artery surgery. METHODS: Group I (n: 25 patients): Mannitol 1 g/kg was added into the priming solution for CPB. Group II (n: 25 patients): IV dopamine was administered at a dose of 2 μg/kg/min during the time period between anesthesia induction and end of surgery...
September 2015: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/26640926/perioperative-characteristics-of-siblings-undergoing-liver-or-kidney-transplant
#4
Zeynep Ersoy, Aycan Ozdemirkan, Arash Pirat, Adnan Torgay, Gulnaz Arslan, Mehmet Haberal
OBJECTIVES: Reasons for chronic liver and kidney failure may vary; sometimes more than 1 family member may be affected, and may require a transplant. The aim of this study was to examine the similarities or differences between the perioperative characteristics of siblings undergoing liver or kidney transplant. MATERIALS AND METHODS: The medical records of 6 pairs of siblings who underwent liver transplant and 4 pairs of siblings who underwent kidney transplant at Baskent University Hospital between 1989 and 2014 were retrospectively analyzed...
November 2015: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/25542143/characterization-of-human-lymphoblastoid-cell-lines-as-a-novel-in-vitro-test-system-to-predict-the-immunotoxicity-of-xenobiotics
#5
Tijana Markovič, Martina Gobec, David Gurwitz, Irena Mlinarič-Raščan
Evaluating immunomodulatory effects of xenobiotics is an important component of the toxicity studies. Herein we report on the establishment of a novel invitro test system for the immunotoxicity screening of xenobiotics based on human lymphoblastoid cell lines (LCLs). Four immunotoxic compounds; tributyltin chloride, cyclosporine A, benzo(a)pyrene and verapamil hydrochloride, as well as three immune-inert compounds; urethane, furosemide and mannitol were selected for characterization. The treatment of LCLs with immunosuppressive compounds resulted in reduced viability...
February 17, 2015: Toxicology Letters
https://www.readbyqxmd.com/read/25441625/altered-states-of-consciousness-in-small-animals
#6
Simon Platt
Impaired states of consciousness can be relatively easily identified, although it can occasionally be difficult to assess whether there is a pure disorder of wakefulness or awareness. Regardless, such impairments represent dysfunction of the brainstem and or cerebrum. Acute and severe impairments of consciousness can require immediate assessment, in part currently performed using the modified Glasgow coma scoring system, and emergency stabilization. The prognosis is always guarded and highly sensitive to the underlying etiology...
November 2014: Veterinary Clinics of North America. Small Animal Practice
https://www.readbyqxmd.com/read/24801161/diuretic-exposure-in-premature-infants-from-1997-to-2011
#7
Matthew M Laughon, Kim Chantala, Sofia Aliaga, Amy H Herring, Christoph P Hornik, Rachel Hughes, Reese H Clark, P Brian Smith
OBJECTIVE: Diuretics are often prescribed off-label to premature infants, particularly to prevent or treat bronchopulmonary dysplasia. We examined their use and safety in this group. STUDY DESIGN: Retrospective cohort study of infants < 32 weeks gestation and < 1,500 g birth weight exposed to diuretics in 333 neonatal intensive care units from 1997 to 2011. We examined use of acetazolamide, amiloride, bumetanide, chlorothiazide, diazoxide, ethacrynic acid, furosemide, hydrochlorothiazide, mannitol, metolazone, or spironolactone combination...
January 2015: American Journal of Perinatology
https://www.readbyqxmd.com/read/24714850/extravasation-of-noncytotoxic-drugs-a-review-of-the-literature
#8
Ann Le, Samit Patel
OBJECTIVE: Extravasation is a potential complication associated with intravenous therapy administration. Inadvertent leakage of medications with vesicant properties can cause severe tissue necrosis, which can lead to devastating long-term consequences. Recognizing potential agents is an essential step in mitigating the risk of extravasation. DATA SOURCE: A literature search was carried out using PubMed with the following key words: extravasation, soft tissue injury, phlebitis, and infiltration, from January 1961 through January 2014...
July 2014: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/24570596/higher-diastolic-blood-pressure-at-admission-and-antiedema-therapy-is-associated-with-acute-kidney-injury-in-acute-ischemic-stroke-patients
#9
Hasan Micozkadioglu
Antiedema therapy with mannitol and furosemide is widely used for prevention and management of cerebral edema, elevated intracranial pressure, and cerebral hernia. There are some reports about mannitol and furosemide as risk factors of acute kidney injury (AKI). We investigated the risk factors for AKI including antiedema therapy in acute ischemic stroke patients. The subjects were 129 patients with acute ischemic stroke including 56 females and 73 males with a mean age 68.16±12.29 years. Patients were divided into two groups: patients with AKI and without AKI according to Acute Kidney Injury Network criteria...
2014: International Journal of Nephrology and Renovascular Disease
https://www.readbyqxmd.com/read/24422671/radiation-therapy-combined-with-intracerebral-administration-of-carboplatin-for-the-treatment-of-brain-tumors
#10
Weilian Yang, Rolf F Barth, Tianyao Huo, Robin J Nakkula, Michael Weldon, Nilendu Gupta, Lawrence Agius, John C Grecula
BACKGROUND: In this study we determined if treatment combining radiation therapy (RT) with intracerebral (i.c.) administration of carboplatin to F98 glioma bearing rats could improve survival over that previously reported by us with a 15 Gy dose (5 Gy × 3) of 6 MV photons. METHODS: First, in order to reduce tumor interstitial pressure, a biodistribution study was carried out to determine if pretreatment with dexamethasone alone or in combination with mannitol and furosemide (DMF) would increase carboplatin uptake following convection enhanced delivery (CED)...
2014: Radiation Oncology
https://www.readbyqxmd.com/read/24364273/-planning-of-cardiothoracic-surgery-for-chronic-kidney-disease-patients
#11
REVIEW
Yasuhisa Okamoto, Tosihiro Nohmi, Koichiro Seki, Yuki Higa
Chronic renal failure (CRF) is related to cardiac diseases. Cardiac surgery is also related to postoperative acute kidney injury (AKI). It means heart and kidney have close relationship. We analyzed recent published data to understand how to manage CRF patients undergoing cardiovascular surgeries. We compared endovascular surgery and open procedure for aortic aneurysm, especially about contrast media-related renal damage, On or Off CABG or PCI for ischemic heart disease. We also discussed the relation between cardiopulmonary bypass and AKI and the risk factors causing AKI after CPB...
November 2013: Masui. the Japanese Journal of Anesthesiology
https://www.readbyqxmd.com/read/24296540/anesthetic-management-of-neurosurgical-procedures-during-pregnancy-a-case-series
#12
Pooya Kazemi, Giselle Villar, Alana M Flexman
INTRODUCTION: Neurosurgical disorders are rare during pregnancy and challenge the anesthesiologist with conflicting anesthetic considerations and little evidence to guide decision-making. Our objective was to review the anesthetic management of pregnant patients undergoing intracranial neurosurgery at our institution and to describe the perioperative complications and outcomes. METHODS: We used our institutional Discharge Abstract Database to identify patients assigned both neurological and obstetrical International Classification of Disease 10-A codes between April 1, 2001 and March 1, 2012...
July 2014: Journal of Neurosurgical Anesthesiology
https://www.readbyqxmd.com/read/24065426/early-neurological-complications-after-transcatheter-closure-of-atrial-septal-defect-with-nitinol-wire-mesh-occluder
#13
Jeronimo Daniel Heredia, Małgorzata Szkutnik, Roland Fiszer, Maria Żyła-Frycz, Jacek Białkowski
Atrial septal defect (ASD) was closed percutaneously in an 18-year-old boy with a 27 mm nitinol wire mesh occluder according to standard procedures. Three hours after the procedure, he presented anxiety attacks, aggression, a vacant stare and a verbal/speaking disorder. Small ischaemic stroke localised in the right temporal/parietal region of the central nervous system was confirmed by computed tomography examination. Activated partial thromboplastin time was then 54 s despite continuous heparin infusion. Heparin dose was increased and symptomatic treatment was introduced (mannitol, furosemide, propofol, haloperidol)...
2013: Kardiologia Polska
https://www.readbyqxmd.com/read/23803159/the-effects-of-mannitol-on-the-transport-of-ciprofloxacin-across-respiratory-epithelia
#14
Hui Xin Ong, Daniela Traini, Rania Salama, Sandra D Anderson, Evangelia Daviskas, Paul M Young
Inhalation of antibiotics and mucolytics is the most important combination of inhaled drugs for chronic obstructive lung diseases and has become a standard part of treatment. However, it is yet to be determined whether the administration of a mucolytic has an effect on the transport rate of antibiotics across the airway epithelial cells. Consequently, the aim of this study was to investigate the effects of inhalation dry powder, specifically mannitol, on ciprofloxacin transport using a Calu-3 air-interface cell model...
August 5, 2013: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/23442754/comparison-of-equivolume-equiosmolar-solutions-of-mannitol-and-hypertonic-saline-with-or-without-furosemide-on-brain-water-content-in-normal-rats
#15
COMPARATIVE STUDY
Liang Chao Wang, Alexander Papangelou, Christopher Lin, Marek A Mirski, Allan Gottschalk, Thomas J K Toung
BACKGROUND: Mannitol and hypertonic saline (HS) are used by clinicians to reduce brain water and intracranial pressure and have been evaluated in a variety of experimental and clinical protocols. Administering equivolume, equiosmolar solutions in healthy animals could help produce fundamental data on water translocation in uninjured tissue. Furthermore, the role of furosemide as an adjunct to osmotherapy remains unclear. METHODS: Two hundred twenty isoflurane-anesthetized rats were assigned randomly to receive equivolume normal saline, 4...
April 2013: Anesthesiology
https://www.readbyqxmd.com/read/23317053/iatrogenic-water-intoxication-in-two-cats
#16
Joyce Y Lee, Elizabeth Rozanski, Maryanne Anastasio, Valerie J Parker, Armelle deLaforcade, John Anastasio
OBJECTIVE: To describe 2 cats that developed acute iatrogenic water intoxication, one associated with a continuous infusion of water provided via an esophagostomy tube and one following SC administration of 5% dextrose in water (D5W). CASE OR SERIES SUMMARY: A 10-year-old cat with squamous cell carcinoma was hospitalized for treatment of dehydration. Rehydration was provided with water via an esophagostomy tube at 5.7 mL/kg/h. After 30 hours of therapy, the cat was found dull and weak...
January 2013: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/23303489/hyperosmolar-therapy-and-the-brain-a-hundred-years-of-hard-earned-lessons
#17
EDITORIAL
Michael M Todd
No abstract text is available yet for this article.
April 2013: Anesthesiology
https://www.readbyqxmd.com/read/23242033/the-use-of-mannitol-in-partial-and-live-donor-nephrectomy-an-international-survey
#18
MULTICENTER STUDY
M Cosentino, A Breda, F Sanguedolce, J Landman, J-U Stolzenburg, P Verze, J Rassweiler, H Van Poppel, H C Klingler, G Janetschek, A Celia, F J Kim, G Thalmann, U Nagele, A Mogorovich, C Bolenz, T Knoll, F Porpiglia, M Alvarez-Maestro, F Francesca, F Deho, S Eggener, C Abbou, M V Meng, M Aron, P Laguna, D Mladenov, A D'Addessi, P Bove, R Schiavina, O De Cobelli, A S Merseburger, O Dalpiaz, F C H D'Ancona, T J Polascik, R Muschter, T J Leppert, H Villavicencio
PURPOSE: Animal studies have shown the potential benefits of mannitol as renoprotective during warm ischemia; it may have antioxidant and anti-inflammatory properties and is sometimes used during partial nephrectomy (PN) and live donor nephrectomy (LDN). Despite this, a prospective study on mannitol has never been performed. The aim of this study is to document patterns of mannitol use during PN and LDN. MATERIALS AND METHODS: A survey on the use of mannitol during PN and LDN was sent to 92 high surgical volume urological centers...
August 2013: World Journal of Urology
https://www.readbyqxmd.com/read/23237936/the-effect-of-furosemide-on-intravascular-volume-status-and-electrolytes-in-patients-receiving-mannitol-an-intraoperative-safety-analysis
#19
RANDOMIZED CONTROLLED TRIAL
John F Bebawy, Vijay K Ramaiah, Carine Zeeni, Laura B Hemmer, Antoun Koht, Dhanesh K Gupta
BACKGROUND: Mannitol is often used during intracranial surgery to improve surgical exposure. Furosemide is often added to mannitol to augment this effect. The concern exists, however, that the augmented diuresis caused by the addition of furosemide to mannitol may cause hypovolemia and hypoperfusion, hypokalemia, and hyponatremia. We examined the intraoperative safety of low-dose furosemide (0.3 mg/kg) combined with mannitol (1 g/kg). METHODS: We observed 23 patients in a double-blind, block randomized, placebo-controlled study to examine the effects of furosemide (0...
January 2013: Journal of Neurosurgical Anesthesiology
https://www.readbyqxmd.com/read/23205279/hydration-with-magnesium-and-mannitol-without-furosemide-prevents-the-nephrotoxicity-induced-by-cisplatin-and-pemetrexed-in-patients-with-advanced-non-small-cell-lung-cancer
#20
Keiko Muraki, Ryo Koyama, Yuichiro Honma, Shigehiro Yagishita, Takehito Shukuya, Rina Ohashi, Fumiyuki Takahashi, Kenji Kido, Shin-Ichiro Iwakami, Shinichi Sasaki, Akihiko Iwase, Kazuhisa Takahashi
BACKGROUND: The aim of this study was to examine the effect of hydration with magnesium and mannitol without furosemide on the nephrotoxocity accompanying combination chemotherapy using cisplatin and pemetrexed in patients with advanced non-small cell lung cancer (NSCLC). METHODS: Fifty patients with NSCLC who received cisplatin plus pemetrexed, using either old hydration protocol including normal saline with mannitol and furosemide, or a new one including normal saline with magnesium and mannitol without furosemide were retrospectively analyzed...
December 2012: Journal of Thoracic Disease
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