Elena Denisenko, Leanne de Kock, Adeline Tan, Aaron B Beasley, Maria Beilin, Matthew E Jones, Rui Hou, Dáithí Ó Muirí, Sanela Bilic, G Raj K A Mohan, Stuart Salfinger, Simon Fox, Khaing P W Hmon, Yen Yeow, Youngmi Kim, Rhea John, Tami S Gilderman, Emily Killingbeck, Elin S Gray, Paul A Cohen, Yu Yu, Alistair R R Forrest
High-grade serous ovarian carcinoma (HGSOC) is genetically unstable and characterised by the presence of subclones with distinct genotypes. Intratumoural heterogeneity is linked to recurrence, chemotherapy resistance, and poor prognosis. Here, we use spatial transcriptomics to identify HGSOC subclones and study their association with infiltrating cell populations. Visium spatial transcriptomics reveals multiple tumour subclones with different copy number alterations present within individual tumour sections...
April 3, 2024: Nature Communications