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https://www.readbyqxmd.com/read/29136542/cognition-and-behaviour-in-children-with-congenital-abdominal-wall-defects
#1
Alice C Burnett, Julia K Gunn, Esther A Hutchinson, Margaret M Moran, Lisa M Kelly, Ursula C Sevil, Peter J Anderson, Rod W Hunt
AIM: To characterise neurodevelopment at age two years and cognition and behaviour at age five years in children born with abdominal wall defects (gastroschisis or exomphalos). STUDY DESIGN: Participants were treated as neonates for gastroschisis or exomphalos and invited for routine clinical follow-up at ages two and five years. Thirty-nine two year-olds and 20 five year-olds with gastroschisis and 20 two year-olds and 10 five year-olds with exomphalos returned for age-appropriate assessments of development (two years) and intellectual functioning (IQ), executive function, and behavioural problems...
November 11, 2017: Early Human Development
https://www.readbyqxmd.com/read/29132332/first-and-second-year-medical-students-identify-and-self-stereotype-more-as-doctors-than-as-students-a-questionnaire-study
#2
Bryan Burford, Harriet E S Rosenthal-Stott
BACKGROUND: The emergence of medical students' professional identity is important. This paper considers this in a snapshot of the early years of undergraduate medical education. From the perspective of social identity theory, it also considers self-stereotyping, the extent to which individuals associate with attributes identified as typical of groups. METHOD: Paper questionnaires were completed by first and second year medical students following teaching sessions at the beginning (October) and end (April) of the academic year...
November 13, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/29132291/hiv-prevention-needs-for-men-who-have-sex-with-men-in-swaziland
#3
Bhekie Sithole
Men who have sex with men (MSM) have a high HIV burden and also often face multiple other challenges accessing HIV services, including legal and social issues. Although Swaziland recently started responding with interventions for MSM, significant gaps still exist both in information and programming. This study aimed to explore the HIV prevention needs of MSM in Swaziland, including factors elevating their risks and vulnerabilities to HIV infection; to find out what HIV prevention strategies exist; and to determine how best to meet the prevention needs of MSM...
December 2017: African Journal of AIDS Research: AJAR
https://www.readbyqxmd.com/read/29130469/-heparan-sulphates-amyloidosis-and-neurodegeneration
#4
REVIEW
C Vera, J A Alvarez-Orozco, A Maiza, S Chantepie, R N Chehin, M O Ouidja, D Papy-Garcia
INTRODUCTION: A number of neurodegenerative disorders have been linked directly to the accumulation of amyloid fibres. These fibres are made up of proteins or peptides with altered structures and which join together in vivo in association with heparan sulphate-type polysaccharides. AIMS: To examine the most recent concepts in the biology of heparan sulphates and their role in the aggregation of the peptide Abeta, of tau protein, of alpha-synuclein and of prions...
November 16, 2017: Revista de Neurologia
https://www.readbyqxmd.com/read/29129790/in-vitro-osteogenesis-by-intracellular-uptake-of-strontium-containing-bioactive-glass-nanoparticles
#5
Parichart Naruphontjirakul, Alexandra E Porter, Julian R Jones
Monodispersed strontium containing bioactive glass nanoparticles (Sr-BGNPs) with two compositions were synthesised, through a modified sol-gel Stöber process, wherein silica nanoparticles (SiO2-NPs) were formed prior to incorporation of calcium and strontium, with diameters of 90 ± 10 nm. The osteogenic response of a murine preosteoblast cell line, MC3T3-E1, was investigated in vitro for a nanoparticle concentration of 250 µg/mL with compositions of 87 mol% SiO2, 7 mol% CaO, 6 mol% SrO and 83 mol% SiO2, 3 mol% CaO, 14 mol% SrO...
November 9, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29112317/-prostate-cancer-is-far-more-hidden%C3%A2-perceptions-of-stigma-social-isolation-and-help-seeking-among-men-with-prostate-cancer
#6
K A Ettridge, J A Bowden, S K Chambers, D P Smith, M Murphy, S M Evans, D Roder, C L Miller
The purpose of this study was to provide in-depth insight into men's experiences of prostate cancer, specifically: perceived stigma and self-blame, social isolation, unmet need and help-seeking. A qualitative descriptive approach was used. Semi-structured interviews were undertaken with 20 men diagnosed with prostate cancer, and thematic analysis was undertaken. Some participants perceived a stigma associated with prostate cancer and cancer in general, which sometimes acted as a barrier to disclosure. Self-blame and internalisation of cause was not a prominent issue...
November 7, 2017: European Journal of Cancer Care
https://www.readbyqxmd.com/read/29107178/1-25-dihydroxycholecalciferol-calcitriol-modifies-uptake-and-release-of-25-hydroxycholecalciferol-in-skeletal-muscle-cells-in-culture
#7
M Abboud, M S Rybchyn, Y J Ning, T C Brennan-Speranza, C M Girgis, J E Gunton, D R Fraser, R S Mason
The major circulating metabolite of vitamin D3, 25-hydroxycholecalciferol [25(OH)D], has a remarkably long half-life in blood for a (seco)steroid. Data from our studies and others are consistent with the hypothesis that there is a role for skeletal muscle in the maintenance of vitamin D status. Muscle cells internalise vitamin D-binding protein (DBP) from the circulation by means of a megalin/cubilin plasma membrane transport mechanism. The internalised DBP molecules then bind to actin and thus provide an intracellular array of high affinity binding sites for its specific ligand, 25(OH)D...
October 26, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29096089/behavioural-and-biochemical-responses-to-metals-tested-alone-or-in-mixture-cd-cu-ni-pb-zn-in-gammarus-fossarum-from-a-multi-biomarker-approach-to-modelling-metal-mixture-toxicity
#8
Jérémie D Lebrun, Emmanuelle Uher, Lise C Fechner
Metals are usually present as mixtures at low concentrations in aquatic ecosystems. However, the toxicity and sub-lethal effects of metal mixtures on organisms are still poorly addressed in environmental risk assessment. Here we investigated the biochemical and behavioural responses of Gammarus fossarum to Cu, Cd, Ni, Pb and Zn tested individually or in mixture (M2X) at concentrations twice the levels of environmental quality standards (EQSs) from the European Water Framework Directive. The same metal mixture was also tested with concentrations equivalent to EQSs (M1X), thus in a regulatory context, as EQSs are proposed to protect aquatic biota...
October 27, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/29071190/accumulation-of-111-in-labelled-egf-au-peg-nanoparticles-in-egfr-positive-tumours-is-enhanced-by-coadministration-of-targeting-ligand
#9
Lei Song, Sarah Able, Errin Johnson, Katherine A Vallis
The successful use of targeted radionuclide therapy in the treatment of solid tumours may be limited by radioresistance, which necessitates delivery of a high dose of radioactivity. Nanoparticle (NP)-based delivery systems possess a large surface area for attachment of radioisotopes and so offer a solution to this challenge. However, tumour uptake may be limited by rapid hepatic clearance of NP via the mononuclear phagocyte system. Liver uptake is further compounded when epidermal growth factor (EGF) is used as a targeting ligand, as EGF-tagged NP bind the EGF receptor (EGFR), which is expressed to a moderate extent by hepatocytes...
2017: Nanotheranostics
https://www.readbyqxmd.com/read/29065110/antibody-drug-conjugates-and-bystander-killing-is-antigen-dependent-internalisation-required
#10
Alexander H Staudacher, Michael P Brown
Antibody drug conjugates (ADCs) employ the exquisite specificity of tumour-specific monoclonal antibodies (mAb) for the targeted delivery of highly potent cytotoxic drugs to the tumour site. The chemistry of the linker, which connects the drug to the mAb, determines how and when the drug is released from the mAb. This, as well as the chemistry of the drug, can dictate whether the drug can diffuse into surrounding cells, resulting in 'bystander killing'. Initially, any bystander killing mechanism of action of an ADC was understood to involve an essential sequence of steps beginning with surface antigen targeting, internalisation, intracellular linker cleavage, drug release, and diffusion of drug away from the targeted cell...
October 24, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29061049/complementary-imaging-of-silver-nanoparticle-interactions-with-green-algae-dark-field-microscopy-electron-microscopy-and-nanoscale-secondary-ion-mass-spectrometry
#11
Ryo Sekine, Katie L Moore, Marianne Matzke, Pascal Vallotton, Haibo Jiang, Gareth M Hughes, Jason K Kirby, Erica Donner, Chris R M Grovenor, Claus Svendsen, Enzo Lombi
Increasing consumer use of engineered nanomaterials has led to significantly increased efforts to understand their potential impact on the environment and living organisms. Currently, no individual technique can provide all the necessary information such as their size, distribution, and chemistry in complex biological systems. Consequently, there is a need to develop complementary instrumental imaging approaches that provide enhanced understanding of these "bio-nano" interactions to overcome the limitations of individual techniques...
November 13, 2017: ACS Nano
https://www.readbyqxmd.com/read/29056306/imaging-in-focus-imaging-the-dynamics-of-endocytosis
#12
Morgane Rosendale, David Perrais
Endocytosis, the formation of membrane vesicles from the plasma membrane, is an essential feature of eukaryotic cell biology. Intense research effort has been dedicated to developing methods that can detect endocytosis events with the highest resolution. We have classified these methods into four families. They exploit the physical properties of endocytosis, namely: 1. Distinguishing extracellular from internalised cargo in fixed samples, 2. Monitoring endosomal acidification, 3. Measuring the turnover of endocytic zones and 4...
October 19, 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/29055773/the-relationship-between-facebook-and-instagram-appearance-focused-activities-and-body-image-concerns-in-young-women
#13
Rachel Cohen, Toby Newton-John, Amy Slater
The present study aimed to identify the specific social networking sites (SNS) features that relate to body image concerns in young women. A total of 259 women aged 18-29years completed questionnaire measures of SNS use (Facebook and Instagram) and body image concerns. It was found that appearance-focused SNS use, rather than overall SNS use, was related to body image concerns in young women. Specifically, greater engagement in photo activities on Facebook, but not general Facebook use, was associated with greater thin-ideal internalisation and body surveillance...
October 19, 2017: Body Image
https://www.readbyqxmd.com/read/29052754/development-of-a-method-for-the-detection-of-polystyrene-microplastics-in-paraffin-embedded-histological-sections
#14
Cátia Gonçalves, Marta Martins, Maria H Costa, Pedro M Costa
The concerns about the presence of microplastics (MPs) in marine ecosystems have widely increased in the past years. This is reflected in a growing number of studies addressing the effects of exposure to these materials in indigenous, farmed and even laboratory marine animals subjected to toxicity-oriented bioassays. There have been, however, many constraints in the detection of MPs in biological tissues, as routine histological techniques tend to degrade these materials, which are especially sensitive to organic solvents...
October 20, 2017: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/29051177/high-intelligence-and-the-risk-of-adhd-and-other-psychopathology
#15
Nanda Rommelse, Kevin Antshel, Stijn Smeets, Corina Greven, Lianne Hoogeveen, Stephen V Faraone, Catharina A Hartman
BackgroundHigh intelligence may be associated with positive (adaptive, desired) outcomes, but may also come with disadvantages.AimsTo contribute empirically to the debate concerning whether a trade-off in IQ scores exists in relation to attention-deficit hyperactivity disorder (ADHD) and related problems, suggesting that high intelligence - like low intelligence - increases the risk of ADHD.MethodCurves of the relation between IQ score and ADHD problems were fitted to questionnaire data (parent, teacher, self-report) in a population-based study of 2221 children and adolescents aged 10-12 years...
October 19, 2017: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/29050986/rac1-plays-a-role-in-cxcl12-but-not-ccl3-induced-chemotaxis-and-rac1-gef-inhibitor-nsc23766-has-off-target-effects-on-cxcr4
#16
Shirley C Mills, Lesley Howell, Andrew Beekman, Leanne Stokes, Anja Mueller
Cell migration towards a chemotactic stimulus relies on the re-arrangement of the cytoskeleton, which is triggered by activation of small G proteins RhoA, Rac1 and Cdc42, and leads to formation of lamellopodia and actin polymerisation amongst other effects. Here we show that Rac1 is important for CXCR4 induced chemotaxis but not for CCR1/CCR5 induced chemotaxis. For CXCL12-induced migration via CXCR4, breast cancer MCF-7 cells are reliant on Rac1, similarly to THP-1 monocytes and Jurkat T-cells. For CCL3-induced migration via CCR1 and/or CCR5, Rac1 signalling does not regulate cell migration in either suspension or adherent cells...
October 16, 2017: Cellular Signalling
https://www.readbyqxmd.com/read/29045912/the-lived-experience-of-first-year-undergraduate-student-nurses-a-hermeneutic-phenomenological-study
#17
Debra J Porteous, Alison Machin
INTRODUCTION: This study gives insight into the experiences and perceptions of one group of undergraduate nursing students as they make the transition into Higher Education and the nursing profession, during the first year, of their three-year programme. Research has shown that first year undergraduate experience is complex and challenging for any student. For undergraduate nursing students, the process of achieving additional professional practice competencies required for United Kingdom nursing registration adds additional responsibility and potentially, more pressure...
October 3, 2017: Nurse Education Today
https://www.readbyqxmd.com/read/29042374/-what-does-that-mean-a-qualitative-exploration-of-the-primary-and-secondary-clinical-care-experiences-of-young-people-with-continence-problems-in-the-uk
#18
Katie Whale, Helen Cramer, Anne Wright, Caroline Sanders, Carol Joinson
OBJECTIVES: To explore the clinical care experiences of young people with continence problems. DESIGN: In-depth semistructured qualitative interviews were conducted by Skype and telephone, with the addition of art-based participatory research techniques. Transcripts were analysed using inductive thematic analysis. SETTING: Primary and secondary care in the UK. PARTICIPANTS: We interviewed 20 participants (9 females, 11 males) aged 11-20 years...
October 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/29025841/neighbourhood-characteristics-and-mental-disorders-in-three-chinese-cities-multilevel-models-from-the-world-mental-health-surveys
#19
Alexandre Dias Porto Chiavegatto Filho, Laura Sampson, Silvia S Martins, Shui Yu, Yueqin Huang, Yanling He, Sing Lee, Chiyi Hu, Alan Zaslavsky, Ronald C Kessler, Sandro Galea
OBJECTIVES: The rapid growth of urban areas in China in the past few decades has introduced profound changes in family structure and income distribution that could plausibly affect mental health. Although multilevel studies of the influence of area-level socioeconomic factors on mental health have become more common in other parts of the world, a study of this sort has not been carried out in Chinese cities. Our objectives were to examine the associations of two key neighbourhood-level variables-median income and percentage of married individuals living in the neighbourhood-with mental disorders net of individual-level income and marital status in three Chinese cities...
October 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/29025489/evidence-based-interventions-to-reduce-tuberculosis-stigma-a-systematic-review
#20
N Sommerland, E Wouters, E M H Mitchell, M Ngicho, L Redwood, C Masquillier, R van Hoorn, S van den Hof, A Van Rie
SETTING: While substantial progress is being made in tuberculosis (TB) control, the success of public health efforts is hampered by pervasive stigma. OBJECTIVE: To perform a systematic literature review to assess the effectiveness of interventions aimed at reducing TB stigma in patients, health care workers, care givers and the general community. DESIGN: Studies were eligible for inclusion if they evaluated interventions aimed at reducing TB stigma and were published between 1950 and 2015...
November 1, 2017: International Journal of Tuberculosis and Lung Disease
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