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https://www.readbyqxmd.com/read/27911717/extracellular-matrix-endocytosis-in-controlling-matrix-turnover-and-beyond-emerging-roles-in-cancer
#1
REVIEW
Elena Rainero
The extracellular matrix (ECM) is a network of secreted proteins that, beyond providing support for tissues and organs, is involved in the regulation of a variety of cell functions, including cell proliferation, polarity, migration and oncogenic transformation. ECM homeostasis is maintained through a tightly controlled balance between synthesis, deposition and degradation. While the role of metalloproteases in ECM degradation is widely recognised, the contribution of ECM internalisation and intracellular degradation to ECM maintenance has been mostly overlooked...
October 15, 2016: Biochemical Society Transactions
https://www.readbyqxmd.com/read/27909606/knowledge-levels-and-attitudes-of-people-living-in-the-city-centre-of-nev%C3%A5-ehir-on-organ-donation-and-transplantation
#2
Mehmet Akif Yazar, Mehmet Barış Açıkgöz
OBJECTIVE: The purpose of this descriptive study was to determine the knowledge levels and attitudes of people living in Nevşehir on organ donation (OD) and transplantation. METHODS: Data were collected using a questionnaire administered to 414 people residing in Nevşehir between February and May 2016. The primary and secondary endpoints of the present study were to determine the attitudes and knowledge levels of participants on OD and transplantation, respectively...
October 2016: Turkish Journal of Anaesthesiology and Reanimation
https://www.readbyqxmd.com/read/27893860/blocking-synthesis-of-the-variant-surface-glycoprotein-coat-in-trypanosoma-brucei-leads-to-an-increase-in-macrophage-phagocytosis-due-to-reduced-clearance-of-surface-coat-antibodies
#3
Jackie L Y Cheung, Nadina V Wand, Cher-Pheng Ooi, Sophie Ridewood, Richard J Wheeler, Gloria Rudenko
The extracellular bloodstream form parasite Trypanosoma brucei is supremely adapted to escape the host innate and adaptive immune system. Evasion is mediated through an antigenically variable Variant Surface Glycoprotein (VSG) coat, which is recycled at extraordinarily high rates. Blocking VSG synthesis triggers a precytokinesis arrest where stalled cells persist for days in vitro with superficially intact VSG coats, but are rapidly cleared within hours in mice. We therefore investigated the role of VSG synthesis in trypanosome phagocytosis by activated mouse macrophages...
November 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27886311/flexible-synthesis-of-cationic-peptide-porphyrin-derivatives-for-light-triggered-drug-delivery-and-photodynamic-therapy
#4
R Dondi, E Yaghini, K M Tewari, L Wang, F Giuntini, M Loizidou, A J MacRobert, I M Eggleston
Efficient syntheses of cell-penetrating peptide-porphyrin conjugates are described using a variety of bioconjugation chemistries. This provides a flexible means to convert essentially hydrophobic tetrapyrolle photosensitisers into amphiphilic derivatives which are well-suited for use in light-triggered drug delivery by photochemical internalisation (PCI) and targeted photodynamic therapy (PDT).
November 25, 2016: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/27876392/metallothionein-assisted-periplasmic-lead-sequestration-as-lead-sulfite-by-providencia-vermicola-strain-sj2a
#5
Jaya Sharma, Kashif Shamim, Santosh Kumar Dubey, Ram Murti Meena
Lead resistant Providencia vermicola strain SJ2A was isolated from the waste of a battery manufacturing industry which could tolerate upto 3.0mM lead nitrate in the minimal medium. Interestingly, this isolate showed presence of a plasmid borne metallothionein gene, bmtA that matched significantly (96%) with that of Pseudomonas aeruginosa. Scanning electron micrographs of bacterial cells exposed to lead revealed a unique alteration in the cell morphology from rods to long inter-connected filaments. On the other hand, electron dispersive X-ray spectroscopy (EDX) clearly indicated no significant lead adsorption therefore, we speculated intracellular sequestration in this bacterial strain...
November 19, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27866898/optimizing-dose-enhancement-with-ta2o5-nanoparticles-for-synchrotron-microbeam-activated-radiation-therapy
#6
Elette Engels, Stéphanie Corde, Sally McKinnon, Sébastien Incerti, Konstantin Konstantinov, Anatoly Rosenfeld, Moeava Tehei, Michael Lerch, Susanna Guatelli
Microbeam Radiation Therapy (MRT) exploits tumour selectivity and normal tissue sparing with spatially fractionated kilovoltage X-ray microbeams through the dose volume effect. Experimental measurements with Ta2O5 nanoparticles (NPs) in 9L gliosarcoma treated with MRT at the Australian Synchrotron, increased the treatment efficiency. Ta2O5 NPs were observed to form shells around cell nuclei which may be the reason for their efficiency in MRT. In this article, our experimental observation of NP shell formation is the basis of a Geant4 radiation transport study to characterise dose enhancement by Ta2O5 NPs in MRT...
November 17, 2016: Physica Medica: PM
https://www.readbyqxmd.com/read/27856392/why-is-depression-more-common-among-women-than-among-men
#7
REVIEW
Christine Kuehner
Women are about twice as likely as are men to develop depression during their lifetime. This Series paper summarises evidence regarding the epidemiology on gender differences in prevalence, incidence, and course of depression, and factors possibly explaining the gender gap. Gender-related subtypes of depression are suggested to exist, of which the developmental subtype has the strongest potential to contribute to the gender gap. Limited evidence exists for risk factors to be specifically linked to depression...
November 11, 2016: Lancet Psychiatry
https://www.readbyqxmd.com/read/27843907/targeting-hmga2-in-retinoblastoma-cells-in-vitro-using-the-aptamer-strategy
#8
Venkatesan Nalini, Perinkulam Ravi Deepa, Rajeswari Raguraman, Vikas Khetan, Maddy Ashwin Reddy, Subramanian Krishnakumar
High-mobility group A2 (HMGA2) protein regulates retinoblastoma (RB) cancer cell proliferation. Here, a stable phosphorothioate-modified HMGA2 aptamer was used to block HMGA2 protein function in RB cells. HMGA2-aptamer internalisation in RB cells (Y79, Weri Rb1) and non-neoplastic human retinal cells (MIO-M1) were optimised. Aptamer induced dose-dependent cytotoxicity in RB cancer cells (0.25-1.5 µM). Increased expression of TGFβ, SMAD4, CDH1, BAX, CASP 3, PARP mRNA and decreased SNAI1, Bcl2 mRNA levels in aptamer-treated RB cells suggests the activation of TGFβ-SMAD4-mediated apoptotic pathway...
October 2016: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/27824139/rna-seq-analyses-of-the-midgut-from-blood-and-serum-fed-ixodes-ricinus-ticks
#9
Jan Perner, Jan Provazník, Jana Schrenková, Veronika Urbanová, José M C Ribeiro, Petr Kopáček
Adult females of the genus Ixodes imbibe blood meals exceeding about 100 times their own weight within 7‒9 days. During this period, ticks internalise components of host blood by endocytic digest cells that line the tick midgut epithelium. Using RNA-seq, we aimed to characterise the midgut transcriptome composition in adult Ixodes ricinus females during early and late phase of engorgement. To address specific adaptations to the haemoglobin-rich diet, we compared the midgut transcriptomes of genetically homogenous female siblings fed either bovine blood or haemoglobin-depleted serum...
November 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27816606/surr9c84a-protects-and-recovers-human-cardiomyocytes-from-hypoxia-induced-apoptosis
#10
Ajay Ashok, Jagat Rakesh Kanwar, Uma Maheswari Krishnan, Rupinder Kaur Kanwar
Survivin, as an anti-apoptotic protein and a cell cycle regulator, is recently gaining importance for its regenerative potential in salvaging injured hypoxic cells of vital organs such as heart. Different strategies are being employed to upregulate survivin expression in dying hypoxic cardiomyocytes. We investigated the cardioprotective potential of a cell permeable survivin mutant protein SurR9C84A, for the management of hypoxia mediated cardiomyocyte apoptosis, in a novel and clinically relevant model employing primary human cardiomyocytes (HCM)...
November 2, 2016: Experimental Cell Research
https://www.readbyqxmd.com/read/27801745/bidirectional-associations-between-sport-involvement-and-mental-health-in-adolescence
#11
Stewart A Vella, Christian Swann, Mark S Allen, Matthew Schweickle, Christopher A Magee
PURPOSE: To investigate potential bidirectional relationships between sport participation and mental health during early adolescence. METHODS: Data were taken from wave 5 (2012) and wave 6 (2014) of the K-Cohort of the Longitudinal Study of Australian Children. In total, there were 4023 participants aged 12.41 (SD = 0.49) years at baseline, and this sample were followed up 24 months later. Cross lagged panel models were used to examine bidirectional relationships between sport participation (hours·wk for team, individual and total sport participation) and mental health (total psychological difficulties, internalising problems, and externalising problems) as measured by the parent-report version of the Strengths and Difficulties Questionnaire...
October 31, 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27798458/the-angiotensin-type-2-receptor-and-the-kidney
#12
Antonio A B Peluso, Robson A S Santos, Thomas Unger, U Muscha Steckelings
PURPOSE OF REVIEW: Angiotensin II is a main regulator of kidney function. Renal actions mediated by the angiotensin AT1 receptor have been well known for many years. In contrast, several details of angiotensin AT2 receptor actions in kidney physiology and pathophysiology were only described very recently. These findings are reviewed in this article. RECENT FINDINGS: Regarding the role of the angiotensin AT2 receptor in kidney physiology, a major recent finding was that the AT2 receptor-mediated inhibition of Na-H exchanger-3 and Na/K-ATPase in the renal proximal tubules is caused by internalisation of these transporters, thus reducing reabsorption and increasing natriuresis/diuresis...
January 2017: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/27796160/effective-self-regulation-change-techniques-to-promote-mental-wellbeing-among-adolescents-a-meta-analysis
#13
Lenneke van Genugten, Elise Dusseldorp, Emma K Massey, Pepijn van Empelen
Mental wellbeing is influenced by self-regulation processes. However, little is known on the efficacy of change techniques based on self-regulation to promote mental wellbeing. The aim of this meta-analysis is to identify effective self-regulation techniques (SRTs) in primary and secondary prevention interventions on mental wellbeing in adolescents. Forty interventions were included in the analyses. Techniques were coded into 9 categories of SRTs. Meta-analyses were conducted to identify the effectiveness of SRTs, examining three different outcomes: internalising behaviour, externalising behaviour and self-esteem...
October 31, 2016: Health Psychology Review
https://www.readbyqxmd.com/read/27794191/modulation-of-iron-transport-metabolism-and-reactive-oxygen-status-by-quercetin-iron-complexes-in-vitro
#14
Richard D Horniblow, Daisy Henesy, Tariq H Iqbal, Chris Tselepis
SCOPE: Excess free-iron is detrimental to health through its ability to participate in free radical generation and amplification of oncogenic pathways. The study aims were to identify polyphenols with iron-chelating potential. METHODS AND RESULTS: Of four polyphenols tested quercetin demonstrated potent iron binding with the physiological outcome dictated by the location of interaction. In the presence of extracellular iron and quercetin, ferritin expression and cellular iron concentrations decreased suggesting the resulting quercetin-iron complex is not internalised...
October 29, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27784778/the-relationship-between-perfectionistic-self-presentation-and-reactions-to-impairment-and-disability-following-spinal-cord-injury
#15
Daniel J Read, Andrew P Hill, Gareth E Jowett, Sarah L Astill
Univariate and multivariate relationships between perfectionistic self-presentation and reactions to impairment and disability following spinal cord injury were examined. A total of 144 adults with spinal cord injury (M = 48.18 years old, SD = 15.96) completed self-report measures. Analyses revealed that, after controlling for time since injury and gender, perfectionistic self-presentation predicted six of eight reactions, shock, depression and internalised anger particularly strongly. In addition, at multivariate level, perfectionistic self-presentation was positively related to non-adaptive reactions and negatively related to adaptive reactions...
October 26, 2016: Journal of Health Psychology
https://www.readbyqxmd.com/read/27781224/kinetic-and-thermodynamic-determinants-of-trace-metal-partitioning-at-biointerphases-the-role-of-intracellular-speciation-dynamics
#16
Jérôme F L Duval, Romain M Présent, Elise Rotureau
There is a large body of work evidencing the necessity to evaluate chemical speciation dynamics of trace metals in solution for an accurate definition of their bioavailability to microorganisms. In contrast, the integration of intracellular metal speciation dynamics in biouptake formalisms is still in its early stages. Accordingly, we elaborate here a rationale for the interplay between chemodynamics of intracellular metal complexes and dynamics of processes governing metal biouptake under non-complexing outer medium conditions...
October 26, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27757969/relationships-between-parenting-practices-and-perceptions-of-child-behaviour-among-korean-immigrant-mothers-and-fathers
#17
Boram Lee, Louise J Keown, Gavin T L Brown
This study examined parenting styles and culturally-specific parenting practices of Korean immigrant mothers (N = 128) and fathers (N = 79) of children (ages 6-10) in New Zealand and the parenting predictors of child behaviour. Participants completed questionnaires on parenting styles and practices, and parental perceptions of child behaviour. Both parents indicated a high degree of devotion (Mo jeong) and involvement in care and education of their child with fathers were more likely than mothers to utilise shaming/love withdrawal and modesty encouragement...
October 18, 2016: International Journal of Psychology: Journal International de Psychologie
https://www.readbyqxmd.com/read/27751744/the-alzheimer-s-related-amyloid-beta-peptide-is-internalised-by-r28-neuroretinal-cells-and-disrupts-the-microtubule-associated-protein-2-map-2
#18
George Taylor-Walker, Savannah A Lynn, Eloise Keeling, Rosie Munday, David A Johnston, Anton Page, Jennifer A Scott, Srini Goverdhan, Andrew J Lotery, J Arjuna Ratnayaka
Age-related Macular Degeneration (AMD) is a common, irreversible blinding condition that leads to the loss of central vision. AMD has a complex aetiology with both genetic as well as environmental risks factors, and share many similarities with Alzheimer's disease. Recent findings have contributed significantly to unravelling its genetic architecture that is yet to be matched by molecular insights. Studies are made more challenging by observations that aged and AMD retinas accumulate the highly pathogenic Alzheimer's-related Amyloid beta (Aβ) group of peptides, for which there appears to be no clear genetic basis...
October 15, 2016: Experimental Eye Research
https://www.readbyqxmd.com/read/27748539/physiological-fluid-flow-moderates-fibroblast-responses-to-tgf-%C3%AE-1
#19
Sadhvi Nithiananthan, Aileen Crawford, Johnathan Cooper Knock, Daniel W Lambert, Simon A Whawell
Fibroblasts are the major cellular component of connective tissue and experience mechanical perturbations due to matrix remodelling and interstitial fluid movement. Transforming growth factor β1 (TGF-β1) can promote differentiation of fibroblasts in vitro to a contractile myofibroblastic phenotype characterised by the presence of α-smooth muscle actin (α-SMA) rich stress fibres. To study the role of mechanical stimulation in this process, we examined the response of primary human fibroblasts to physiological levels of fluid movement and its influence on fibroblast differentiation and responses to TGF-β1...
October 17, 2016: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/27744707/optimization-of-curcumin-loaded-peg-plga-nanoparticles-by-gsh-functionalization-investigation-of-the-internalization-pathway-in-neuronal-cells
#20
Ghislain Djiokeng Paka, Charles Ramassamy
One major challenge in the field of nanotherapeutics is to increase the selective delivery of cargo to targeted cells. Using Poly Lactic-co-Glycolic Acid (PLGA), we recently highlighted the importance of polymer composition in the biological fate of the nanodrug delivery systems. However the route of internalisation of polymeric nanoparticles (NPs) is another key component to consider in the elaboration of modern and targeted devices. For that purpose, herein, we effectively synthesized and characterised glutathione- functionalized PLGA-nanoparticles (GSH-NPs) loaded with curcumin (GSH-NPs-Cur), using thiol-maleimide click reaction and determined their physicochemical properties...
October 15, 2016: Molecular Pharmaceutics
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