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https://www.readbyqxmd.com/read/28428818/does-parent-child-agreement-vary-based-on-presenting-problems-results-from-a-uk-clinical-sample
#1
Kalia Cleridou, Praveetha Patalay, Peter Martin
BACKGROUND: Discrepancies are often found between child and parent reports of child psychopathology, nevertheless the role of the child's presenting difficulties in relation to these is underexplored. This study investigates whether parent-child agreement on the conduct and emotional scales of the Strengths and Difficulties Questionnaire (SDQ) varied as a result of certain child characteristics, including the child's presenting problems to clinical services, age and gender. METHODS: The UK-based sample consisted of 16,754 clinical records of children aged 11-17, the majority of which were female (57%) and White (76%)...
2017: Child and Adolescent Psychiatry and Mental Health
https://www.readbyqxmd.com/read/28425112/beyond-guidelines-discretionary-practice-in-face-to-face-triage-nursing
#2
Lars E F Johannessen
This article draws on ethnographic data from a Norwegian emergency primary care clinic (EPCC) to explore nurses' discretionary application of guidelines. Specifically, it analyses nurses' discretionary use of the Manchester Triage System (MTS) when performing face-to-face triage, that is, assessing the urgency of patients' complaints. The analysis shows how nurses assessed patients at odds with MTS prescriptions by collecting supplementary data, engaging in differential diagnostic and holistic reasoning, relying on emotion and intuition, and allowing colleagues and patients to influence their reasoning...
April 20, 2017: Sociology of Health & Illness
https://www.readbyqxmd.com/read/28422454/childhood-maltreatment-and-adulthood-poor-sleep-quality-a-longitudinal-study
#3
Amanuel Alemu Abajobir, Steve Kisely, Gail Williams, Lane Strathearn, Jake Moses Najman
BACKGROUND: Available evidence from cross-sectional studies suggests that childhood maltreatment may be associated with a range of sleep disorders. However, these studies have not controlled for potential individual, familial and environmental level confounders. AIM: To determine the association between childhood maltreatment and lower sleep quality, after adjusting for potential confounders. METHODS: Data for the present study are from a pre-birth cohort study of 3778 young adults (52...
April 19, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28404476/body-size-ideals-and-dissatisfaction-in-ghanaian-adolescents-role-of-media-lifestyle-and-well-being
#4
N Michels, S D Amenyah
OBJECTIVES: To inspire effective health promotion campaigns, we tested the relationship of ideal body size and body size dissatisfaction with (1) the potential resulting health-influencing factors diet, physical activity and well-being; and (2) with media as a potential influencer of body ideals. STUDY DESIGN: This is a cross-sectional study in 370 Ghanaian adolescents (aged 11-18 years). METHODS: Questionnaires included disordered eating (EAT26), diet quality (FFQ), physical activity (IPAQ), well-being (KINDL) and media influence on appearance (SATAQ: pressure, internalisation and information)...
February 7, 2017: Public Health
https://www.readbyqxmd.com/read/28397273/internalisation-of-escherichia-coli-o157-h7-gfp-in-rocket-and-swiss-chard-baby-leaves-as-affected-by-abiotic-and-biotic-damage
#5
Rahel Hartmann, Andreas Fricke, Hartmut Stützel, Suzan Mansourian, Teun Dekker, Walter Wohanka, Beatrix Alsanius
Internalisation of human pathogens in edible parts of vegetables eaten raw is a major concern, since once internalised they are protected from sanitising treatments. In this study, we examined invasion of gfp-labelled E. coli O157:H7 into intact and biotically (infection with Xanthomonas campestris/Pseudomonas syringae) and abiotically (grating with silicon carbide) damaged leaves of wild rocket (Diplotaxis tenuifolia) and Swiss chard (Beta vulgaris subsp. cicla) using laser scanning confocal microscopy. Bacterial cells were found in internal locations of the tissue, irrespective of tissue health status...
April 11, 2017: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/28394222/exploring-the-impact-of-living-with-dyslexia-the-perspectives-of-children-and-their-parents
#6
Suze Leitão, Peta Dzidic, Mary Claessen, Joanne Gordon, Kate Howard, Mandy Nayton, Mark E Boyes
PURPOSE: A small but growing body of literature indicates that children with dyslexia are at elevated risk of internalising and externalising mental health problems. However, little research addresses why this might be the case, particularly from the point of view of the children or their parents. This study therefore aimed to explore the lived experiences of children with dyslexia, and their parents. METHOD: Drawing on a phenomenological approach, 13 children with dyslexia and 21 parents were interviewed...
April 10, 2017: International Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/28393860/mycobacterium-llatzerense-a-waterborne-mycobacterium-that-resists-phagocytosis-by-acanthamoeba-castellanii
#7
Vincent Delafont, Ascel Samba-Louaka, Emmanuelle Cambau, Didier Bouchon, Laurent Moulin, Yann Héchard
Nontuberculous mycobacteria (NTM) are environmental bacteria increasingly associated to public health problems. In water systems, free-living amoebae (FLA) feed on bacteria by phagocytosis, but several bacteria, including many NTM, are resistant to this predation. Thus, FLA can be seen as a training ground for pathogenic bacteria. Mycobacterium llatzerense was previously described as frequently associated with FLA in a drinking water network. The present study aimed to characterize the interactions between M...
April 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28386390/acute-lymphoblastic-leukaemia-cells-produce-large-extracellular-vesicles-containing-organelles-and-an-active-cytoskeleton
#8
Suzanne M Johnson, Clare Dempsey, Catriona Parker, Aleksandr Mironov, Helen Bradley, Vaskar Saha
Extracellular vesicles have been described in non-paracrine cellular interactions in cancer. We report a similar phenomenon in B-cell precursor (BCP) acute lymphoblastic leukaemia (ALL). Using advanced microscopy and high throughput screening, we further characterise a subset of large vesicles (LEVs) identified in cell lines, murine models of human BCP-ALL and clinical samples. Primary ALL blasts and cell lines released heterogeneous anucleate vesicles <6 micron into extracellular fluids. Larger LEVs were enclosed in continuous membranes, contained intact organelles and demonstrated an organised cytoskeleton...
2017: Journal of Extracellular Vesicles
https://www.readbyqxmd.com/read/28384523/effectiveness-of-a-pragmatic-school-based-universal-intervention-targeting-student-resilience-protective-factors-in-reducing-mental-health-problems-in-adolescents
#9
Julia Dray, Jenny Bowman, Elizabeth Campbell, Megan Freund, Rebecca Hodder, Luke Wolfenden, Jody Richards, Catherine Leane, Sue Green, Christophe Lecathelinais, Christopher Oldmeadow, John Attia, Karen Gillham, John Wiggers
Worldwide, 10-20% of adolescents experience mental health problems. Strategies aimed at strengthening resilience protective factors provide a potential approach for reducing mental health problems in adolescents. This study evaluated the effectiveness of a universal, school-based intervention targeting resilience protective factors in reducing mental health problems in adolescents. A cluster randomised controlled trial was conducted in 20 intervention and 12 control secondary schools located in socio-economically disadvantaged areas of NSW, Australia...
April 3, 2017: Journal of Adolescence
https://www.readbyqxmd.com/read/28373745/payment-for-multiple-forest-benefits-alters-the-effect-of-tree-disease-on-optimal-forest-rotation-length
#10
Morag F Macpherson, Adam Kleczkowski, John R Healey, Nick Hanley
Forests deliver multiple benefits both to their owners and to wider society. However, a wave of forest pests and pathogens is threatening this worldwide. In this paper we examine the effect of disease on the optimal rotation length of a single-aged, single rotation forest when a payment for non-timber benefits, which is offered to private forest owners to partly internalise the social values of forest management, is included. Using a generalisable bioeconomic framework we show how this payment counteracts the negative economic effect of disease by increasing the optimal rotation length, and under some restrictive conditions, even makes it optimal to never harvest the forest...
April 2017: Ecological Economics: the Journal of the International Society for Ecological Economics
https://www.readbyqxmd.com/read/28373101/aptamer-delivery-of-sirna-radiopharmaceutics-and-chemotherapy-agents-in-cancer
#11
Carlos E B de Almeida, Lais Nascimento Alves, Enrique T Paulino, Januário Bispo Cabral-Neto, Sotiris Missailidis
Aptamers are oligonucleotide reagents with high affinity and specificity, which among other therapeutic and diagnostic applications have the capability of acting as delivery agents. Thus, aptamers are capable of carrying small molecules, nanoparticles, radiopharmaceuticals or fluorescent agents as well as nucleic acid therapeutics specifically to their target cells. In most cases, the molecules may possess interesting therapeutic properties, but their lack of specificity for a particular cell type, or ability to internalise in such a cell, hinders their clinical development, or cause unwanted side effects...
March 31, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28364141/long-term-neuropsychological-outcomes-of-childhood-onset-acute-disseminated-encephalomyelitis-adem-a-meta-analysis
#12
REVIEW
Karen L O Burton, Tracey A Williams, Sarah E Catchpoole, Ruth K Brunsdon
The long-term neurocognitive prognosis of childhood onset acute disseminated encephalomyelitis (ADEM) is unclear. This review and quantitative synthesis of the available literature examined whether there are long-term impacts of childhood ADEM on neurocognitive functioning. A search of online databases (MEDLINE, EMBASE, EBSCO CINAHL, PsycINFO and the Cochrane Database of Systematic Reviews) from their inception to October 2015 and reference lists identified 13 papers eligible for inclusion in the systematic review; seven of these were eligible for inclusion in meta-analyses...
March 31, 2017: Neuropsychology Review
https://www.readbyqxmd.com/read/28357372/bacterial-genotoxin-functions-as-immune-modulator-and-promotes-host-survival
#13
COMMENT
R Guidi, L Del Bell Belluz, T Frisan
Bacterial genotoxins are effectors that cause DNA damage in target cells. Many aspects of the biology of these toxins have been characterised in vitro, such as structure, cellular internalisation pathways and effects on the target cells. However, little is known about their function in vivo. Salmonella enterica serovar Typhi (S. Typhi) is a Gram-negative, intracellular bacterium that causes typhoid fever, a debilitating disease infecting more than 20 million people every year. S. Typhiproduce a genotoxin named typhoid toxin (TT), but its role in the contest of host infection is poorly characterized...
July 28, 2016: Microbial Cell
https://www.readbyqxmd.com/read/28356530/role-of-neuraminidase-in-influenza-a-h7n9-receptor-binding
#14
Donald J Benton, Stephen A Wharton, Stephen R Martin, John W McCauley
Influenza A(H7N9) viruses have caused a large number of zoonotic infections since their emergence in 2013. They remain a public health concern due to their repeated high levels of infection and perceived pandemic potential. A major factor that determines influenza A virus fitness and therefore transmissibility is the interaction of the surface glycoproteins haemagglutinin (HA) and neuraminidase (NA) with the cell surface receptor sialic acid. Typically, the HA is responsible for binding to the sialic acid to allow virus internalisation and the NA is a sialidase, responsible for cleaving sialic acid to aid virus spread and release...
March 29, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28344335/influenza-a-virus-hemagglutinin-and-neuraminidase-act-as-novel-motile-machinery
#15
Tatsuya Sakai, Shin I Nishimura, Tadasuke Naito, Mineki Saito
Influenza A virus (IAV) membrane proteins hemagglutinin (HA) and neuraminidase (NA) are determinants of virus infectivity, transmissibility, pathogenicity, host specificity, and major antigenicity. HA binds to a virus receptor, a sialoglycoprotein or sialoglycolipid, on the host cell and mediates virus attachment to the cell surface. The hydrolytic enzyme NA cleaves sialic acid from viral receptors and accelerates the release of progeny virus from host cells. In this study, we identified a novel function of HA and NA as machinery for viral motility...
March 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28341445/insulin-promotes-cell-migration-by-regulating-psa-ncam
#16
Hector J Monzo, Natacha Coppieters, Thomas I H Park, Birger V Dieriks, Richard L M Faull, Mike Dragunow, Maurice A Curtis
Cellular interactions with the extracellular environment are modulated by cell surface polysialic acid (PSA) carried by the neural cell adhesion molecule (NCAM). PSA-NCAM is involved in cellular processes such as differentiation, plasticity, and migration, and is elevated in Alzheimer's disease as well as in metastatic tumour cells. Our previous work demonstrated that insulin enhances the abundance of cell surface PSA by inhibiting PSA-NCAM endocytosis. In the present study we have identified a mechanism for insulin-dependent inhibition of PSA-NCAM turnover affecting cell migration...
March 21, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28337939/bidirectional-apical-basal-traffic-of-the-cation-independent-mannose-6-phosphate-receptor-in-brain-endothelial-cells
#17
Piotr Siupka, Maria Ns Hersom, Karin Lykke-Hartmann, Kasper B Johnsen, Louiza B Thomsen, Thomas L Andresen, Torben Moos, N Joan Abbott, Birger Brodin, Morten S Nielsen
Brain capillary endothelium mediates the exchange of nutrients between blood and brain parenchyma. This barrier function of the brain capillaries also limits passage of pharmaceuticals from blood to brain, which hinders treatment of several neurological disorders. Receptor-mediated transport has been suggested as a potential pharmaceutical delivery route across the brain endothelium, e.g. reports have shown that the transferrin receptor (TfR) facilitates transcytosis of TfR antibodies, but it is not known whether this recycling receptor itself traffics from apical to basal membrane in the process...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28333127/selective-intracellular-vaporisation-of-antibody-conjugated-phase-change-nano-droplets-in-vitro
#18
A Ishijima, K Minamihata, S Yamaguchi, S Yamahira, R Ichikawa, E Kobayashi, M Iijima, Y Shibasaki, T Azuma, T Nagamune, I Sakuma
While chemotherapy is a major mode of cancer therapeutics, its efficacy is limited by systemic toxicities and drug resistance. Recent advances in nanomedicine provide the opportunity to reduce systemic toxicities. However, drug resistance remains a major challenge in cancer treatment research. Here we developed a nanomedicine composed of a phase-change nano-droplet (PCND) and an anti-cancer antibody (9E5), proposing the concept of ultrasound cancer therapy with intracellular vaporisation. PCND is a liquid perfluorocarbon nanoparticle with a liquid-gas phase that is transformable upon exposure to ultrasound...
March 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28327657/dynasore-impairs-vegfr2-signalling-in-an-endocytosis-independent-manner
#19
Dimitris Basagiannis, Sofia Zografou, Katerina Galanopoulou, Savvas Christoforidis
VEGFR2 is a critical angiogenic receptor playing a key role in vascular homeostasis. Upon activation by VEGF, VEGFR2 becomes endocytosed. Internalisation of VEGFR2 is facilitated, in part, through clathrin mediated endocytosis (CME), the role of which in VEGFR2 function is debated. Here, we confirm the contribution of CME in VEGFR2 uptake. However, curiously, we find that different approaches of inhibition of CME exert contradictory effects on VEGF signalling; knockdown of clathrin, or of dynamin, or overexpression of dynamin K44A, do not affect VEGF-induced phosphorylation of ERK1/2, while dynasore causes strong inhibition...
March 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28314993/comparative-analysis-of-internalisation-haemolytic-cytotoxic-and-antibacterial-effect-of-membrane-active-cationic-peptides-aspects-of-experimental-setup
#20
Kata Horváti, Bernadett Bacsa, Tamás Mlinkó, Nóra Szabó, Ferenc Hudecz, Ferenc Zsila, Szilvia Bősze
Cationic peptides proved fundamental importance as pharmaceutical agents and/or drug carrier moieties functioning in cellular processes. The comparison of the in vitro activity of these peptides is an experimental challenge and a combination of different methods, such as cytotoxicity, internalisation rate, haemolytic and antibacterial effect, is necessary. At the same time, several issues need to be addressed as the assay conditions have a great influence on the measured biological effects and the experimental setup needs to be optimised...
March 17, 2017: Amino Acids
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