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Boram Lee, Louise J Keown, Gavin T L Brown
This study examined parenting styles and culturally-specific parenting practices of Korean immigrant mothers (N = 128) and fathers (N = 79) of children (ages 6-10) in New Zealand and the parenting predictors of child behaviour. Participants completed questionnaires on parenting styles and practices, and parental perceptions of child behaviour. Both parents indicated a high degree of devotion (Mo jeong) and involvement in care and education of their child with fathers were more likely than mothers to utilise shaming/love withdrawal and modesty encouragement...
October 18, 2016: International Journal of Psychology: Journal International de Psychologie
George Taylor-Walker, Savannah A Lynn, Eloise Keeling, Rosie Munday, David A Johnston, Anton Page, Jennifer A Scott, Srini Goverdhan, Andrew J Lotery, J Arjuna Ratnayaka
Age-related Macular Degeneration (AMD) is a common, irreversible blinding condition that leads to the loss of central vision. AMD has a complex aetiology with both genetic as well as environmental risks factors, and share many similarities with Alzheimer's disease. Recent findings have contributed significantly to unravelling its genetic architecture that is yet to be matched by molecular insights. Studies are made more challenging by observations that aged and AMD retinas accumulate the highly pathogenic Alzheimer's-related Amyloid beta (Aβ) group of peptides, for which there appears to be no clear genetic basis...
October 14, 2016: Experimental Eye Research
Sadhvi Nithiananthan, Aileen Crawford, Johnathan Cooper Knock, Daniel W Lambert, Simon A Whawell
Fibroblasts are the major cellular component of connective tissue and experience mechanical perturbations due to matrix remodelling and interstitial fluid movement. Transforming growth factor β1 (TGF-β1) can promote differentiation of fibroblasts in vitro to a contractile myofibroblastic phenotype characterised by the presence of α-smooth muscle actin (α-SMA) rich stress fibres. To study the role of mechanical stimulation in this process, we examined the response of primary human fibroblasts to physiological levels of fluid movement and its influence on fibroblast differentiation and responses to TGF-β1...
October 17, 2016: Journal of Cellular Biochemistry
Ghislain Djiokeng Paka, Charles Ramassamy
One major challenge in the field of nanotherapeutics is to increase the selective delivery of cargo to targeted cells. Using Poly Lactic-co-Glycolic Acid (PLGA), we recently highlighted the importance of polymer composition in the biological fate of the nanodrug delivery systems. However the route of internalisation of polymeric nanoparticles (NPs) is another key component to consider in the elaboration of modern and targeted devices. For that purpose, herein, we effectively synthesized and characterised glutathione- functionalized PLGA-nanoparticles (GSH-NPs) loaded with curcumin (GSH-NPs-Cur), using thiol-maleimide click reaction and determined their physicochemical properties...
October 15, 2016: Molecular Pharmaceutics
Niels Chr Hansen, Peter Vuust, Marcus Pearce
Musical expertise entails meticulous stylistic specialisation and enculturation. Even so, research on musical training effects has focused on generalised comparisons between musicians and non-musicians, and cross-cultural work addressing specialised expertise has traded cultural specificity and sensitivity for other methodological limitations. This study aimed to experimentally dissociate the effects of specialised stylistic training and general musical expertise on the perception of melodies. Non-musicians and professional musicians specialising in classical music or jazz listened to sampled renditions of saxophone solos improvised by Charlie Parker in the bebop style...
2016: PloS One
Inken Lorenzen, Juliane Lokau, Yvonne Korpys, Mirja Oldefest, Charlotte M Flynn, Ulrike Künzel, Christoph Garbers, Matthew Freeman, Joachim Grötzinger, Stefan Düsterhöft
An important, irreversible step in many signalling pathways is the shedding of membrane-anchored proteins. A Disintegrin And Metalloproteinase (ADAM) 17 is one of the major sheddases involved in a variety of physiological and pathophysiological processes including regeneration, differentiation, and cancer progression. This central role in signalling implies that ADAM17 activity has to be tightly regulated, including at the level of localisation. Most mature ADAM17 is localised intracellularly, with only a small amount at the cell surface...
October 12, 2016: Scientific Reports
Anna K Stalder, Dominik Lott, Daniel S Strasser, Hans G Cruz, Andreas Krause, Peter M A Groenen, Jasper Dingemanse
AIMS: The main objectives of these two Phase 1 studies were to investigate safety and tolerability as well as the pharmacokinetic/pharmacodynamic profile of the novel potent and selective FPR2/ALX agonist ACT-389949. A challenge model was used to assess the drug's anti-inflammatory potential with the aim of selecting a dosing regimen for future patient studies. METHODS: Two double-blind, randomized Phase 1 studies investigated safety, tolerability, pharmacokinetics, and pharmacodynamics of ACT-389949 at different doses and dosing regimens...
October 11, 2016: British Journal of Clinical Pharmacology
Xi Chen, Jiwei Cui, Yuan Ping, Tomoya Suma, Francesca Cavalieri, Quinn A Besford, George Chen, Julia A Braunger, Frank Caruso
We report polymer capsule-based probes for quantifying the pressure exerted by cells during capsule internalisation (Pin). Poly(methacrylic acid) (PMA) capsules with tuneable mechanical properties were fabricated through layer-by-layer assembly. The Pin was quantified by correlating the cell-induced deformation with the ex situ osmotically induced deformation of the polymer capsules. Ultimately, we found that human monocyte-derived macrophage THP-1 cells exerted up to approximately 360 kPa on the capsules during internalisation...
October 6, 2016: Nanoscale
Lia Ahonen, Rolf Loeber
BACKGROUND: Teen dating violence (TDV) is a common phenomenon of great public concern. TDV may lead to severe long-term consequences for victims and offenders, and even more so for females than for males. AIM: The aim of this paper is to investigate possible underlying factors for involvement in TDV either as a perpetrator or a victim. Social learning theory is commonly used to explain internalisation of parents' behaviour on children's behavioural expressions, but less so on parents' emotion regulation as a direct link to later TDV...
October 2016: Criminal Behaviour and Mental Health: CBMH
Karl Sydow, Heike Nikolenko, Dorothea Lorenz, Rainer H Müller, Margitta Dathe
Lipopeptide-based micelles and liposomes were found to differ in cell recognition and uptake mode into blood brain barrier (BBB) endothelial cells. Here we analyze the role of size and surface charge of micelles and liposomes composed of different lipopeptide sequences with respect to uptake into human brain capillary (HBMEC) and aortic (HAoEC) endothelial cells. Comparable to the dipalmitoylated apolipoprotein E-derived P2A2, lipopeptides of cationic poly-arginine (P2Rn), poly-lysine (P2Kn) and an anionic glutamic-acid sequence (P2En) self assemble into micelles (12-14 nm in diameter) with high surface charge density, and bind to small (SUVs, about 24 nm in diameter) and large (LUV, about 100 nm in diameter) liposomes at variable lipid to peptide ratios...
October 1, 2016: European Journal of Pharmaceutics and Biopharmaceutics
Lovisa Göstring, Sture Lindegren, Lars Gedda
The geldanamycin derivative 17-allylamino-17-demethoxygeldanamycin (17-AAG) is known to induce internalisation and degradation of the otherwise internalisation-resistant human epidermal growth factor receptor 2 (HER2) receptor. In the present study, 17-AAG was used to increase internalisation of the HER2-specific Affibody molecule ABY-025. The cellular redistribution of halogen-labelled (211)At-ABY-025 and radiometal-labelled (111)In-ABY-025 following treatment with 17-AAG was studied. 17-AAG treatment of SKOV-3 human ovarian carcinoma and SKBR-3 human breast carcinoma cells to some extent shifted the localisation of (111)In-ABY-025 from the cell surface to intracellular compartments in the two cell lines...
October 2016: Oncology Letters
Michaela Matthes, Ramón A Torres-Ruiz
Several observations suggest that the micronutrient boron (B) has a stabilizing role in the plasma membrane (PM), supporting functions in PM-linked (hormone) signalling processes. However, this role is poorly characterized. This study shows, that boronic acids, specific competitors of B, induce phenocopies of the Arabidopsis thaliana rootless pattern mutant monopteros At least in part, this is caused by phenylboronic acid (PBA)-induced internalisation of the membrane-localized auxin efflux carrier PINFORMED1 (PIN1) in the early embryo...
October 3, 2016: Development
Caroline A Flurey, Sarah Hewlett, Karen Rodham, Alan White, Robert Noddings, John R Kirwan
OBJECTIVE: To identify typologies of experiences and coping strategies of men with rheumatoid arthritis (RA). DESIGN: Q-methodology (a qualitative and quantitative approach to grouping people according to their subjective opinion). Men with RA sorted 64 statements relating to their experience of living with RA according to level of agreement across a normal distribution grid. Data were examined using Q-factor analysis. SETTING: Rheumatology outpatient departments in the UK...
October 3, 2016: BMJ Open
Karlie Rice, Ivanka Prichard, Marika Tiggemann, Amy Slater
Barbie doll ownership is high among girls in early primary school. It has been suggested that exposure to Barbie impacts negatively on body image. The present study sought to investigate the effect of exposure to Barbie on young girls' thin-ideal internalisation, body esteem, and body dissatisfaction. Participants were 160 girls (aged 5-8 years) from Adelaide, South Australia. They were randomly allocated one of three Barbie conditions (physical engagement, physical observation, print observation) or to a control toy...
September 30, 2016: Body Image
D Rigoli, R T Kane, V Mancini, A Thornton, M Licari, B Hands, F McIntyre, J Piek
Growing evidence has highlighted the importance of motor proficiency in relation to psychosocial outcomes including self-perceived competence in various domains, perceived social support, and emotional areas such as anxiety and depression. The Environmental Stress Hypothesis-elaborated (Cairney, Rigoli, & Piek, 2013) is a proposed theoretical framework for understanding these relationships and recent studies have begun examining parts of this model using child and adolescent populations. However, the extent to which the relationships between these areas exist, persist or change during early adulthood is currently unclear...
September 30, 2016: Human Movement Science
Irene Malkwitz, Angela Berndt, Runhui Zhang, Arwid Daugschies, Berit Bangoura
Toxoplasma (T.) gondii is able to infect various cell types in different hosts. The replication of this parasite within different peripheral mononuclear blood cell populations in chicken has not yet been fully understood. Aim of the present study was to investigate the impact of chicken erythrocytes and thrombocytes as potential host cells for T. gondii. Cultures of primary avian erythrocytes and thrombocytes were inoculated with tachyzoites of T. gondii type II strain ME49. Parasite replication was detected by a quantitative real-time PCR at different times postinoculation until 24 or 48 h, respectively, displaying long-term investigations for the chosen cultures...
October 3, 2016: Parasitology Research
Pedro M Costa, Maxime Bourgognon, Julie T-W Wang, Khuloud T Al-Jamal
Carbon nanotubes (CNTs) have long been regarded as promising carriers in biomedicine. Due to their high surface area and unique needle-like structure, CNTs are uniquely equipped to carry therapeutic molecules across biological membranes and, therefore, have been widely researched for use in theranostic applications. The attractive properties of the CNTs entice also their use in the brain environment. Cutting edge brain-specific therapies, capable of circumventing the physical and biochemical blockage of the blood-brain barrier, could be a precious tool to tackle brain disorders...
November 10, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
Clara Mockdece Neves, Juliana Fernandes Filgueiras Meireles, Pedro Henrique Berbert de Carvalho, Astrid Schubring, Natalie Barker-Ruchti, Maria Elisa Caputo Ferreira
Body dissatisfaction is prevalent in women's artistic gymnastics (WAG). Cross-sectional research points to social and individual risk factors, however it does not account for potential changes in body dissatisfaction during an athletic season. This study aimed to determine how gymnasts' body dissatisfaction, risk factors for eating disorders, media internalisation, perfectionism and mood state change during pre-competition, competition and post-competition seasons and to identify how these psychosocial indicators impact on body dissatisfaction during the athletic year...
October 3, 2016: Journal of Sports Sciences
E C McKenzie, L V Eyrich, M E Payton, S J Valberg
A previous report suggests a substantial incidence of exertional rhabdomyolysis (ER) in Arabian horses performing endurance racing. This study compared formalin histopathology and clinical and metabolic responses to a standardised field exercise test (SET) between Arabians with and without ER. Arabian horses with (n = 10; age 15.4 ± 5.6 years) and without (n = 9; 12.9 ± 6.1 years) prior ER were stall-rested for 24-48 h, after which paired ER and control horses were fitted with a telemetric ECG and performed a 47 min submaximal SET...
October 2016: Veterinary Journal
M L Taylor, C Gwinnett, L F Robinson, L C Woodall
Plastic waste is a distinctive indicator of the world-wide impact of anthropogenic activities. Both macro- and micro-plastics are found in the ocean, but as yet little is known about their ultimate fate and their impact on marine ecosystems. In this study we present the first evidence that microplastics are already becoming integrated into deep-water organisms. By examining organisms that live on the deep-sea floor we show that plastic microfibres are ingested and internalised by members of at least three major phyla with different feeding mechanisms...
September 30, 2016: Scientific Reports
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