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https://www.readbyqxmd.com/read/28637519/gender-associated-developmental-trajectories-of-sdq-dysregulation-profile-and-its-predictors-in-children
#1
B Kunze, B Wang, C Isensee, R Schlack, U Ravens-Sieberer, F Klasen, A Rothenberger, A Becker
BACKGROUND: Severe mood dysregulation is common in childhood and can be highly impairing. The Dysregulation Profile (DP) can be considered as a broader phenotype of emotional dysregulation, including affect, cognition and behaviour. Since mood dysregulation may persist, but differently in boys and girls, the gender associated course needs to be considered longitudinally to gain a better insight in order to support the children more adequately. This study is focusing on gender associated subgroup trajectories of the Strengths and Difficulties Questionnaire-Dysregulation Profile (SDQ-DP) in middle childhood (9-13 years of age) and includes the potential impact of clinical and psychosocial characteristics...
June 22, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28637475/uptake-of-label-free-graphene-oxide-by-caco-2-cells-is-dependent-on-the-cell-differentiation-status
#2
Melanie Kucki, Liliane Diener, Nils Bohmer, Cordula Hirsch, Harald F Krug, Vincenzo Palermo, Peter Wick
BACKGROUND: Understanding the interaction of graphene-related materials (GRM) with human cells is a key to the assessment of their potential risks for human health. There is a knowledge gap regarding the potential uptake of GRM by human intestinal cells after unintended ingestion. Therefore the aim of our study was to investigate the interaction of label-free graphene oxide (GO) with the intestinal cell line Caco-2 in vitro and to shed light on the influence of the cell phenotype given by the differentiation status on cellular uptake behaviour...
June 21, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28625171/the-association-between-adolescent-psychopathology-and-subsequent-physical-activity-in-young-adulthood-a-21-year-birth-cohort-study
#3
S Suetani, A Mamun, G M Williams, J M Najman, J J McGrath, J G Scott
BACKGROUND: The beneficial effects of physical activity (PA) for both physical and mental wellbeing are well established. Given that adolescence presents a critical developmental period during which life-long patterns of PA become established, the exploration of the longitudinal impact of adolescent psychopathology on adult PA status is of interest. METHODS: We analysed prospective data from 3663 young adults who participated in the Mater-University of Queensland Study of Pregnancy...
June 19, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28621485/the-conundrums-of-human-development-implications-for-the-study-of-child-and-adolescent-disorder
#4
EDITORIAL
Alice M Gregory
The conundrums inherent in the study of child and adolescent development are likely never far from the minds of the readers of JCPP. The complexity of development is flagged clearly in this issue. Included papers remind us that the link between associations (here maternal depression and child internalising problems) can change over short time periods. Even when the magnitude of associations stay consistent over time (here between the home environment and depression), there may be different aetiological processes underlying these links...
July 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28619032/the-role-of-intracellular-trafficking-of-cdse-zns-qds-on-their-consequent-toxicity-profile
#5
Bella B Manshian, Thomas F Martens, Karsten Kantner, Kevin Braeckmans, Stefaan C De Smedt, Jo Demeester, Gareth J S Jenkins, Wolfgang J Parak, Beatriz Pelaz, Shareen H Doak, Uwe Himmelreich, Stefaan J Soenen
BACKGROUND: Nanoparticle interactions with cellular membranes and the kinetics of their transport and localization are important determinants of their functionality and their biological consequences. Understanding these phenomena is fundamental for the translation of such NPs from in vitro to in vivo systems for bioimaging and medical applications. Two CdSe/ZnS quantum dots (QD) with differing surface functionality (NH2 or COOH moieties) were used here for investigating the intracellular uptake and transport kinetics of these QDs...
June 15, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28610653/prospective-cohort-study-of-childhood-behaviour-problems-and-adolescent-sexual-risk-taking-gender-matters
#6
S Rachel Skinner, Jennifer Marino, Susan L Rosenthal, Jeffrey Cannon, Dorota A Doherty, Martha Hickey
Background: Externalising (delinquent, aggressive) and internalising (anxious/depressed, withdrawn) behaviour problems are prevalent in childhood. Few studies have prospectively measured relationships between childhood behaviour problems and adolescent health risk behaviour, a major predictor of morbidity and mortality. This study sought to determine relationships, by gender, between childhood behaviour problems and adolescent risky sexual behaviours and substance use. Methods: In a population-based birth cohort [The Western Australian Pregnancy Cohort (Raine) Study], total, externalising and internalising behaviour problems (domain-specific T≥60) were calculated from parent-reported Child Behavior Checklist at ages 2, 5, 8, 10 and 14 years...
June 14, 2017: Sexual Health
https://www.readbyqxmd.com/read/28606391/tensions-in-relation-how-peer-support-is-experienced-and-received-in-a-hepatitis-c-treatment-intervention
#7
Oliver Bonnington, Magdalena Harris
BACKGROUND: Peer support and involvement is recognised as a vital component of hepatitis C (HCV) treatment provision for marginalised populations, such as people who inject drugs (PWID). Developments in HCV treatments enable increased provision in community settings - expanding the possibilities for meaningful peer involvement in HCV treatment plans. To date, HCV peer support has generally been viewed as a positive intervention, with little critical reflection on the ways social structures, policies, health and drug services and social identity impact on how peer support is experienced and received...
June 9, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28600500/using-nanobret-and-crispr-cas9-to-monitor-proximity-to-a-genome-edited-protein-in-real-time
#8
Carl W White, Hannah K Vanyai, Heng B See, Elizabeth K M Johnstone, Kevin D G Pfleger
Bioluminescence resonance energy transfer (BRET) has been a vital tool for understanding G protein-coupled receptor (GPCR) function. It has been used to investigate GPCR-protein and/or -ligand interactions as well as GPCR oligomerisation. However the utility of BRET is limited by the requirement that the fusion proteins, and in particular the donor, need to be exogenously expressed. To address this, we have used CRISPR/Cas9-mediated homology-directed repair to generate protein-Nanoluciferase (Nluc) fusions under endogenous promotion, thus allowing investigation of proximity between the genome-edited protein and an exogenously expressed protein by BRET...
June 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28598368/self-assembled-lipid-nanoparticles-for-oral-delivery-of-heparin-coated-iron-oxide-nanoparticles-for-theranostic-purposes
#9
Eleonora Truzzi, Chiara Bongio, Francesca Sacchetti, Eleonora Maretti, Monica Montanari, Valentina Iannuccelli, Elena Vismara, Eliana Leo
Recently, solid lipid nanoparticles (SLNs) have attracted increasing attention owing to their potential as an oral delivery system, promoting intestinal absorption in the lymphatic circulation which plays a role in disseminating metastatic cancer cells and infectious agents throughout the body. SLN features can be exploited for the oral delivery of theranostics. Therefore, the aim of this work was to design and characterise self-assembled lipid nanoparticles (SALNs) to encapsulate and stabilise iron oxide nanoparticles non-covalently coated with heparin (Fe@hepa) as a model of a theranostic tool...
June 9, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28585019/women-in-the-midluteal-phase-of-the-menstrual-cycle-have-difficulty-suppressing-the-processing-of-negative-emotional-stimuli-an-event-related-potential-study
#10
Bethany R Lusk, Andrea R Carr, Valerie A Ranson, Kim L Felmingham
Emotion regulation deficits have been implicated in anxiety and depressive disorders, and these internalising disorders are more prevalent in women than men. Few electrophysiological studies have investigated sex differences in emotional reactivity and emotion regulation controlling for menstrual phase. Event-related potentials (ERPs) were recorded from 28 early follicular women, 29 midluteal women, and 27 men who completed an emotion regulation task. A novel finding of increased N2 amplitude during suppression was found for midluteal women compared with men...
June 5, 2017: Cognitive, Affective & Behavioral Neuroscience
https://www.readbyqxmd.com/read/28579544/could-clinical-photochemical-internalisation-be-optimised-to-avoid-neuronal-toxicity
#11
Caitriona O'Rourke, Colin Hopper, Alexander J MacRobert, James B Phillips, Josephine H Woodhams
Photochemical Internalisation (PCI) is a novel drug delivery technology in which low dose photodynamic therapy (PDT) can selectively rupture endo/lysosomes by light activation of membrane-incorporated photosensitisers, facilitating intracellular drug release in the treatment of cancer. For PCI to be developed further, it is important to understand whether nerve damage is an impending side effect when treating cancers within or adjacent to nervous system tissue. Dorsal root ganglion (DRG) neurons and their associated satellite glia were subjected to PCI treatment in a 3D co-culture system following incubation with photosensitisers: meso-tetraphenylporphine (TPPS2a) or tetraphenylchlorin disulfonate (TPCS2a) and Bleomycin...
June 1, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28575998/cellular-internalisation-kinetics-and-cytotoxic-properties-of-statistically-designed-and-optimised-neo-geometric-copper-nanocrystals
#12
Karmani Murugan, Yahya E Choonara, Pradeep Kumar, Lisa C du Toit, Viness Pillay
This study aimed to highlight a statistic design to precisely engineer homogenous geometric copper nanoparticles (CuNPs) for enhanced intracellular drug delivery as a function of geometrical structure. CuNPs with a dual functionality comprising geometric attributes for enhanced cell uptake and exerting cytotoxic activity on proliferating cells were synthesized as a novel drug delivery system. This paper investigated the defined concentrations of two key surfactants used in the reaction to mutually control and manipulate nano-shape and optimisation of the geometric nanosystems...
September 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28566373/vimentin-modulates-infectious-internalisation-of-hpv16-pseudovirions
#13
Georgia Schäfer, Lisa M Graham, Dirk Lang, Melissa J Blumenthal, Martina Bergant Marušič, Arieh A Katz
Human papillomavirus (HPV) is the most common viral infection of the reproductive tract, with virtually all cases of cervical cancer being attributable to infection by oncogenic HPVs. However, the exact mechanism and receptors used by HPV to infect epithelial cells is controversial. The current entry model suggests that HPV initially attaches to heparan sulfate proteoglycans (HSPGs) at the cell surface, followed by conformational changes, cleavage by furin convertase and subsequent transfer of the virus to an as yet unidentified high-affinity receptor...
May 31, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28560609/addition-of-exogenous-sod1-aggregates-causes-tdp-43-mislocalisation-and-aggregation
#14
Rafaa Zeineddine, Natalie E Farrawell, Isabella A Lambert-Smith, Justin J Yerbury
ALS is characterised by a focal onset of motor neuron loss, followed by contiguous outward spreading of pathology throughout the nervous system, resulting in paralysis and death generally within a few years after diagnosis. The aberrant release and uptake of toxic proteins including SOD1 and TDP-43 and their subsequent propagation, accumulation and deposition in motor neurons may explain such a pattern of pathology. Previous work has suggested that the internalization of aggregates triggers stress granule formation...
May 30, 2017: Cell Stress & Chaperones
https://www.readbyqxmd.com/read/28558805/development-of-a-12-item-short-version-of-the-hiv-stigma-scale
#15
Maria Reinius, Lena Wettergren, Maria Wiklander, Veronica Svedhem, Anna Mia Ekström, Lars E Eriksson
BACKGROUND: Valid and reliable instruments for the measurement of enacted, anticipated and internalised stigma in people living with HIV are crucial for mapping trends in the prevalence of HIV-related stigma and tracking the effectiveness of stigma-reducing interventions. Although longer instruments exist, e.g., the commonly used 40-item HIV Stigma Scale by Berger et al., a shorter instrument would be preferable to facilitate the inclusion of HIV stigma in more and broader surveys. Therefore, the aim of this work was to develop a substantially shorter, but still valid, version of the HIV Stigma Scale...
May 30, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28544479/drinking-problems-mechanisms-of-macropinosome-formation-and-maturation
#16
REVIEW
Catherine M Buckley, Jason S King
Macropinocytosis is a mechanism for the non-specific bulk uptake and internalisation of extracellular fluid. This plays specific and distinct roles in diverse cell types such as macrophages, dendritic cells and neurons, by allowing cells to sample their environment, extract extracellular nutrients and regulate plasma membrane turnover. Macropinocytosis has recently been implicated in several diseases including cancer, neurodegenerative diseases and atherosclerosis. Uptake by macropinocytosis is also exploited by several intracellular pathogens to gain entry into host cells...
May 24, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28543619/the-company-you-keep-is-socialising-with-higher-status-people-bad-for-mental-health
#17
Min-Ah Lee, Ichiro Kawachi
Socialising with higher-status individuals can be hypothesised to exert opposing influences on the mental health of the ego. On the one hand, socialising with higher-status alters might enable individuals to access valuable resources. On the other hand, status-discrepant friendships could be detrimental to mental health by engendering feelings of unfairness. We sought to examine the impact of status-discrepant social relationships on depressive symptoms in the 2012 Korean General Social Survey (KGSS), a nationally representative sample...
May 24, 2017: Sociology of Health & Illness
https://www.readbyqxmd.com/read/28543538/clinical-and-histopathological-features-of-myofibrillar-myopathy-in-warmblood-horses
#18
S J Valberg, A M Nicholson, S S Lewis, R A Reardon, C J Finno
BACKGROUND: To report a novel exertional myopathy, myofibrillar myopathy (MFM), in Warmblood horses. OBJECTIVES: To 1) describe the distinctive clinical and myopathic features of MFM in Warmblood horses, 2) investigate the potential inheritance of MFM in a Warmblood family. STUDY DESIGN: Retrospective selection of MFM cases and prospective evaluation of a Warmblood family. METHODS: Retrospectively, muscle biopsies were selected from Warmblood horses diagnosed with MFM and clinical histories obtained (n = 10)...
May 22, 2017: Equine Veterinary Journal
https://www.readbyqxmd.com/read/28542473/stably-engineered-nanobubbles-and-ultrasound-an-effective-platform-for-enhanced-macromolecular-delivery-to-representative-cells-of-the-retina
#19
Sachin S Thakur, Micheal S Ward, Amirali Popat, Nicole B Flemming, Marie-Odile Parat, Nigel L Barnett, Harendra S Parekh
Herein we showcase the potential of ultrasound-responsive nanobubbles in enhancing macromolecular permeation through layers of the retina, ultimately leading to significant and direct intracellular delivery; this being effectively demonstrated across three relevant and distinct retinal cell lines. Stably engineered nanobubbles of a highly homogenous and echogenic nature were fully characterised using dynamic light scattering, B-scan ultrasound and transmission electron microscopy (TEM). The nanobubbles appeared as spherical liposome-like structures under TEM, accompanied by an opaque luminal core and darkened corona around their periphery, with both features indicative of efficient gas entrapment and adsorption, respectively...
2017: PloS One
https://www.readbyqxmd.com/read/28540609/mental-health-problems-in-austrian-adolescents-a-nationwide-two-stage-epidemiological-study-applying-dsm-5-criteria
#20
Gudrun Wagner, Michael Zeiler, Karin Waldherr, Julia Philipp, Stefanie Truttmann, Wolfgang Dür, Janet L Treasure, Andreas F K Karwautz
This is a nationwide epidemiological study using DSM-5 criteria to assess the prevalence of mental disorders in a large sample of Austrian adolescents between 10 and 18 years including hard-to-reach samples. A sample of 3615 adolescents from four cohorts (school grades 5, 7, 9, 11; age range 10-18 years) was recruited from 261 schools, samples of unemployed adolescents (n = 39) and adolescents from mental health institutions (n = 137) were added. The Youth Self-Report and SCOFF were used to screen for mental health problems...
May 24, 2017: European Child & Adolescent Psychiatry
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