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https://www.readbyqxmd.com/read/28073033/situating-violent-ideations-within-the-landscape-of-mental-health-associations-between-violent-ideations-and-dimensions-of-mental-health
#1
Aja Louise Murray, Manuel Eisner, Ingrid Obsuth, Denis Ribeaud
Violent ideations occur more frequently in individuals with mental health problems. They may be of interest in clinical contexts as possible indicators of dangerousness, as corollaries of mental health problems, as candidate treatment targets and as potentially playing a role in perpetuation or onset of symptoms. In spite of their relevance to mental health, some fundamental questions about their place within the broader landscape of mental health problems remain unanswered. To provide a basic characterisation of the relations between violent ideations and dimensions of mental health and provide a foundation for future research in this area we factor analysed a measure of violent ideations and an omnibus measure of mental health dimensions in a normative sample of 1306 youth (at age 17)...
January 3, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28068371/in-vitro-assessment-of-the-probiotic-potential-of-lactococcus-lactis-lmg-7930-against-ruminant-mastitis-causing-pathogens
#2
Federica Armas, Cristina Camperio, Cinzia Marianelli
Mastitis in dairy ruminants is considered to be the most expensive disease to farmers worldwide. Recently, the intramammary infusion of lactic acid bacteria has emerged as a potential new alternative to antibiotics for preventing and treating bovine mastitis. In this study we have investigated in vitro the probiotic potential of Lactococcus lactis LMG 7930, a food-grade and nisin-producing strain, against mastitis-causing pathogens. We have characterized its carbohydrate fermentation and antibiotic susceptibility profiles, cell surface properties and antimicrobial activity, as well as its capabilities to adhere to and inhibit the invasion of pathogens into the bovine mammary epithelial cell line BME-UV1d...
2017: PloS One
https://www.readbyqxmd.com/read/28059140/identification-and-functional-characterisation-of-5-ht4-receptor-in-sea-cucumber-apostichopus-japonicus-selenka
#3
Tianming Wang, Zhen Yang, Naiming Zhou, Lina Sun, Zhenming Lv, Changwen Wu
Serotonin (5-HT) is an important neurotransmitter and neuromodulator that controls a variety of sensory and motor functions through 5-HT receptors (5-HTRs). The 5-HT4R subfamily is linked to Gs proteins, which activate adenylyl cyclases (ACs), and is involved in many responses in peripheral organs. In this study, the 5-HT4R from Apostichopus japonicus (Aj5-HT4R) was identified and characterised. The cloned full-length Aj5-HT4R cDNA is 1,544 bp long and contains an open reading frame 1,011 bp in length encoding 336 amino acid proteins...
January 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28051856/enhanced-cellular-internalization-a-bactericidal-mechanism-more-relative-to-biogenic-nanoparticles-than-chemical-counterparts
#4
Madhuree Kumari, Shatrunajay Shukla, Shipra Pandey, Ved P Giri, Anil Bhatia, Tusha Tripathi, Poonam Kakkar, Chandra Shekhar Nautiyal, Aradhana Mishra
Biogenic synthesis of silver nanoparticles for enhanced antimicrobial activity has gained a lot of momentum making it an urgent need to search for a suitable bio-candidate which could be utilized for efficient capping and shaping of silver nanoparticles with enhanced bactericidal activity utilising its secondary metabolites. Current work illustrates the enhancement of antimicrobial efficacy of silver nanoparticles by reducing and modifying their surface with antimicrobial metabolites of cell free extract of Trichoderma viride (MTCC 5661) in comparison to citrate stabilized silver nanoparticles...
January 4, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28028402/academic-achievement-and-psychosocial-profile-of-egyptian-primary-school-children-in-south-sinai
#5
Zeinab M Monir, Ebtissam M Salah El-Din, Inas R El-Alameey, Gamal A Yamamah, Hala S Megahed, Samar M Salem, Tarek S Ibrahim
BACKGROUND: Population of South Sinai has suffered from negligence for many years. Solving educational problems of this population is the main concern nowadays. AIM: To assess academic achievement in primary school children in South Sinai in relation to intelligence and psychosocial profile. SUBJECTS AND METHODS: A descriptive cross-sectional survey was conducted on 407 Bedouin and urban students randomly selected from twelve public primary schools in six cities in South Sinai...
December 15, 2016: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28003220/recycling-of-apolipoprotein-a-after-plgrkt-mediated-endocytosis-of-lipoprotein-a
#6
Monika Sharma, Gregory M Redpath, Michael J Williams, Sally P McCormick
RATIONALE: Lipoprotein(a) [Lp(a)] is a low density lipoprotein (LDL)-like lipoprotein and important cardiovascular risk factor whose cognate receptor and intracellular fate remains unknown. OBJECTIVE: Our study aimed to determine the intracellular trafficking pathway for Lp(a) and the receptor responsible for its uptake in liver cells. METHODS AND RESULTS: Human hepatoma (HepG2) cells were treated with Lp(a) purified from human plasma and Lp(a) uptake studied using western blot analysis and intracellular localisation of Lp(a) by confocal microscopy...
December 21, 2016: Circulation Research
https://www.readbyqxmd.com/read/27998973/nectin-4-a-new-prognostic-biomarker-for-efficient-therapeutic-targeting-of-primary-and-metastatic-triple-negative-breast-cancer
#7
REVIEW
M M-Rabet, O Cabaud, E Josselin, P Finetti, R Castellano, A Farina, E Agavnian-Couquiaud, G Saviane, Y Collette, P Viens, A Gonçalves, C Ginestier, E Charafe-Jauffret, D Birnbaum, D Olive, F Bertucci, M Lopez
BACKGROUND: Triple-negative breast cancers (TNBCs) are associated with a poor prognosis. In contrast to other molecular subtypes, they have no identified specific target and chemotherapy remains the only available systemic treatment. The adhesion molecule nectin-4 represents a new potential therapeutic target in different cancer models. Here, we have tested the prognostic value of nectin-4 expression and assessed the therapeutic efficiency of an anti-nectin 4 antibody drug conjugate (ADC) on localised and metastatic TNBC in vitro and in vivo MATERIAL AND METHODS: : We analysed nectin-4/PVRL4 mRNA expression in 5,673 invasive breast cancers and searched for correlations with clinicopathological features including metastasis-free survival (MFS)...
December 20, 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/27998178/overlapping-hiv-and-sex-work-stigma-among-female-sex-workers-recruited-to-14-respondent-driven-sampling-surveys-across-zimbabwe-2013
#8
J R Hargreaves, J Busza, P Mushati, E Fearon, F M Cowan
HIV stigma can inhibit uptake of HIV testing and antiretroviral therapy as well as negatively affect mental health. Efforts to reduce discrimination against people living with HIV (LWH) have contributed to greater acceptance of the infection. Female sex workers (FSW) LWH may experience overlapping stigma due to both their work and HIV status, although this is poorly understood. We examined HIV and sex-work stigma experienced by FSW LWH in Zimbabwe. Using the SAPPH-IRe cluster-randomised trial baseline survey, we analysed the data from 1039 FSW self-reporting HIV...
December 21, 2016: AIDS Care
https://www.readbyqxmd.com/read/27990161/sex-hormone-binding-globulin-modifies-testosterone-action-and-metabolism-in-prostate-cancer-cells
#9
Huika Li, Thy Pham, Brett C McWhinney, Jacobus P Ungerer, Carel J Pretorius, Derek J Richard, Robin H Mortimer, Michael C d'Emden, Kerry Richard
Sex Hormone Binding Globulin (SHBG) is the major serum carrier of sex hormones. However, growing evidence suggests that SHBG is internalised and plays a role in regulating intracellular hormone action. This study was to determine whether SHBG plays a role in testosterone uptake, metabolism, and action in the androgen sensitive LNCaP prostate cancer cell line. Internalisation of SHBG and testosterone, the effects of SHBG on testosterone uptake, metabolism, regulation of androgen responsive genes, and cell growth were assessed...
2016: International Journal of Endocrinology
https://www.readbyqxmd.com/read/27989562/changing-shape-and-shaping-change-inducing-the-inner-ear
#10
REVIEW
Raj K Ladher
The inner ear arises from non-neural ectoderm as a result of instructions sent by surrounding tissues. These interactions progressively restrict the potential of the ectoderm, resulting in the formation of the otic placode, a disk of thickened ectoderm that will give rise to all of the inner ear derivatives and its neurons. While otic placode is a surface structure, the inner ear is internalised, embedded within the cranial mesenchyme. Here, the cellular and molecular interactions that restrict the lineage of non-neural ectoderm in its transition to otic placode are reviewed, and how these interactions impinge on the coordination of otic placodal cell shape that drive the dramatic morphogenesis of the placode, as it becomes the otocyst...
October 28, 2016: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/27974565/infectious-bursal-disease-virus-subverts-autophagic-vacuoles-to-promote-viral-maturation-and-release
#11
Yongqiang Wang, Yulu Duan, Chunyan Han, Shuai Yao, Xiaole Qi, Yulong Gao, Helena J Maier, Paul Britton, Lei Chen, Lizhou Zhang, Li Gao, Honglei Gao, Nan Shen, Jingfei Wang, Xiaomei Wang
: Autophagy functions as an intrinsic antiviral defence. However, some viruses can subvert or even enhance host autophagic machinery to increase viral replication and pathogenesis. The role of autophagy during Avibirnavirus infection, especially late stage infection, remains unclear. In this study, infectious bursal disease virus (IBDV) was used to investigate the role of autophagy in Avibirnavirus replication. We demonstrated IBDV induction of autophagy as a significant increase in puncta of LC3+ autophagosomes, endogenous levels of LC3-II, and ultrastructural characteristics typical of autophagosomes during the late stage of infection...
December 14, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27973323/predicting-receptive-vocabulary-change-from-childhood-to-adulthood-a-birth-cohort-study
#12
Rebecca Armstrong, James Scott, David Copland, Katie McMahon, Asaduzzaman Khan, Jake M Najman, Rosa Alati, Wendy Arnott
This study examined the parental and early childhood risk factors of different receptive vocabulary developmental profiles from childhood to adulthood. The sample (n=1914), comprised of monolingual English speaking participants, from the Mater University of Queensland Study of Pregnancy (MUSP). Receptive vocabulary was measured using the Peabody Picture Vocabulary Test-Revised (PPVT-R) at the 5 and 21-year follow ups. Four vocabulary profiles were evident: persistently typical, persistently impaired, later onset of difficulties, and resolved delays...
October 19, 2016: Journal of Communication Disorders
https://www.readbyqxmd.com/read/27942048/early-maltreatment-effects-on-adolescent-attention-control-to-non-emotional-and-emotional-distractors
#13
Paul Gray, Helen M Baker, Gaia Scerif, Jennifer Y F Lau
OBJECTIVE: Early maltreatment increases lifetime risk of psychopathology. Emerging models suggest that exposure to maltreatment leads to changes in cognitive processes associated with the processing of threat, including processes of selective attention. Existing data may be interpreted to suggest that maltreatment is associated with an automatic attentional engagement with threatening cues, or that maltreatment is associated with generally poorer attention control. Using a pair of attention tasks, this study sought to examine whether maltreatment was associated with threat-related interference on attention processing and if this could be explained by poorer attentional control capacity...
September 2016: Australian Journal of Psychology
https://www.readbyqxmd.com/read/27934839/internalisation-of-hepatitis-c-virus-core-protein-by-human-conjunctival-fibroblasts
#14
A R Rajalakshmy, J Malathi, H N Madhavan, S Bhaskar, G K Iyer
Recent studies indicate that hepatitis C virus (HCV) proteins can mediate innate immune response and inflammation in conjunctival fibroblasts which contributes to the pathology of dry eye condition associated with chronic HCV infection. The present study investigates the phagocytic potential of human conjunctival fibroblasts (HCFj) for HCV core protein. HCFj cells were incubated with HCV core antigen for different periods of time, and fluorescent micrographs were taken to observe protein internalisation. HCFj cells were capable of internalising HCV core antigen within 1 h; this gives an insight into another molecular mechanism which may contribute towards HCV-associated conjunctival inflammation...
October 2016: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27911717/extracellular-matrix-endocytosis-in-controlling-matrix-turnover-and-beyond-emerging-roles-in-cancer
#15
REVIEW
Elena Rainero
The extracellular matrix (ECM) is a network of secreted proteins that, beyond providing support for tissues and organs, is involved in the regulation of a variety of cell functions, including cell proliferation, polarity, migration and oncogenic transformation. ECM homeostasis is maintained through a tightly controlled balance between synthesis, deposition and degradation. While the role of metalloproteases in ECM degradation is widely recognised, the contribution of ECM internalisation and intracellular degradation to ECM maintenance has been mostly overlooked...
October 15, 2016: Biochemical Society Transactions
https://www.readbyqxmd.com/read/27909606/knowledge-levels-and-attitudes-of-people-living-in-the-city-centre-of-nev%C3%A5-ehir-on-organ-donation-and-transplantation
#16
Mehmet Akif Yazar, Mehmet Barış Açıkgöz
OBJECTIVE: The purpose of this descriptive study was to determine the knowledge levels and attitudes of people living in Nevşehir on organ donation (OD) and transplantation. METHODS: Data were collected using a questionnaire administered to 414 people residing in Nevşehir between February and May 2016. The primary and secondary endpoints of the present study were to determine the attitudes and knowledge levels of participants on OD and transplantation, respectively...
October 2016: Turkish Journal of Anaesthesiology and Reanimation
https://www.readbyqxmd.com/read/27893860/blocking-synthesis-of-the-variant-surface-glycoprotein-coat-in-trypanosoma-brucei-leads-to-an-increase-in-macrophage-phagocytosis-due-to-reduced-clearance-of-surface-coat-antibodies
#17
Jackie L Y Cheung, Nadina V Wand, Cher-Pheng Ooi, Sophie Ridewood, Richard J Wheeler, Gloria Rudenko
The extracellular bloodstream form parasite Trypanosoma brucei is supremely adapted to escape the host innate and adaptive immune system. Evasion is mediated through an antigenically variable Variant Surface Glycoprotein (VSG) coat, which is recycled at extraordinarily high rates. Blocking VSG synthesis triggers a precytokinesis arrest where stalled cells persist for days in vitro with superficially intact VSG coats, but are rapidly cleared within hours in mice. We therefore investigated the role of VSG synthesis in trypanosome phagocytosis by activated mouse macrophages...
November 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27886311/flexible-synthesis-of-cationic-peptide-porphyrin-derivatives-for-light-triggered-drug-delivery-and-photodynamic-therapy
#18
R Dondi, E Yaghini, K M Tewari, L Wang, F Giuntini, M Loizidou, A J MacRobert, I M Eggleston
Efficient syntheses of cell-penetrating peptide-porphyrin conjugates are described using a variety of bioconjugation chemistries. This provides a flexible means to convert essentially hydrophobic tetrapyrolle photosensitisers into amphiphilic derivatives which are well-suited for use in light-triggered drug delivery by photochemical internalisation (PCI) and targeted photodynamic therapy (PDT).
December 7, 2016: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/27876392/metallothionein-assisted-periplasmic-lead-sequestration-as-lead-sulfite-by-providencia-vermicola-strain-sj2a
#19
Jaya Sharma, Kashif Shamim, Santosh Kumar Dubey, Ram Murti Meena
Lead resistant Providencia vermicola strain SJ2A was isolated from the waste of a battery manufacturing industry which could tolerate upto 3.0mM lead nitrate in the minimal medium. Interestingly, this isolate showed presence of a plasmid borne metallothionein gene, bmtA that matched significantly (96%) with that of Pseudomonas aeruginosa. Scanning electron micrographs of bacterial cells exposed to lead revealed a unique alteration in the cell morphology from rods to long inter-connected filaments. On the other hand, electron dispersive X-ray spectroscopy (EDX) clearly indicated no significant lead adsorption therefore, we speculated intracellular sequestration in this bacterial strain...
February 1, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/27866898/optimizing-dose-enhancement-with-ta2o5-nanoparticles-for-synchrotron-microbeam-activated-radiation-therapy
#20
Elette Engels, Stéphanie Corde, Sally McKinnon, Sébastien Incerti, Konstantin Konstantinov, Anatoly Rosenfeld, Moeava Tehei, Michael Lerch, Susanna Guatelli
Microbeam Radiation Therapy (MRT) exploits tumour selectivity and normal tissue sparing with spatially fractionated kilovoltage X-ray microbeams through the dose volume effect. Experimental measurements with Ta2O5 nanoparticles (NPs) in 9L gliosarcoma treated with MRT at the Australian Synchrotron, increased the treatment efficiency. Ta2O5 NPs were observed to form shells around cell nuclei which may be the reason for their efficiency in MRT. In this article, our experimental observation of NP shell formation is the basis of a Geant4 radiation transport study to characterise dose enhancement by Ta2O5 NPs in MRT...
December 2016: Physica Medica: PM
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