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https://www.readbyqxmd.com/read/28195232/hematopoietic-pannexin-1-function-is-critical-for-neuropathic-pain
#1
Janelle L Weaver, Sanja Arandjelovic, Gregory Brown, Suresh K Mendu, Michael S Schappe, Monica W Buckley, Yu-Hsin Chiu, Shaofang Shu, Jin K Kim, Joyce Chung, Julia Krupa, Vesna Jevtovic-Todorovic, Bimal N Desai, Kodi S Ravichandran, Douglas A Bayliss
Neuropathic pain symptoms respond poorly to available therapeutics, with most treated patients reporting unrelieved pain and significant impairment in daily life. Here, we show that Pannexin 1 (Panx1) in hematopoietic cells is required for pain-like responses following nerve injury in mice, and a potential therapeutic target. Panx1 knockout mice (Panx1(-/-)) were protected from hypersensitivity in two sciatic nerve injury models. Bone marrow transplantation studies show that expression of functional Panx1 in hematopoietic cells is necessary for mechanical hypersensitivity following nerve injury...
February 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28192462/development-identification-and-validation-of-caps-marker-for-shell-trait-which-governs-dura-pisifera-and-tenera-fruit-forms-in-oil-palm-elaeis-guineensis-jacq
#2
B Kalyana Babu, R K Mathur, P Naveen Kumar, D Ramajayam, G Ravichandran, M V B Venu, S Sparjan Babu
The oil palm fruit forms (dura, pisifera and tenera) governed by the shell thickness gene (Sh) plays a major role in identification of fruit type and also influences palm oil yield. Identification of desired fruit type is a major asset to the breeders and oil palm workers for applications in breeding, seed certification and to reduce time, space and money spent on identification of fruit form. In the present study, we developed Sh gene specific primer pairs and bulk segregant analysis was done using 300 genomic and 8 genic SSR markers...
2017: PloS One
https://www.readbyqxmd.com/read/28144114/on-line-estimations-of-delivered-radiation-doses-in-three-dimensional-conformal-radiotherapy-treatments-of-carcinoma-uterine-cervix-patients-in-linear-accelerator
#3
Suman Kumar Putha, P U Saxena, S Banerjee, Challapalli Srinivas, B M Vadhiraja, Ramamoorthy Ravichandran, Mary Joan, K Dinesh Pai
Transmission of radiation fluence through patient's body has a correlation to the planned target dose. A method to estimate the delivered dose to target volumes was standardized using a beam level 0.6 cc ionization chamber (IC) positioned at electronic portal imaging device (EPID) plane from the measured transit signal (St) in patients with cancer of uterine cervix treated with three-dimensional conformal radiotherapy (3DCRT). The IC with buildup cap was mounted on linear accelerator EPID frame with fixed source to chamber distance of 146...
October 2016: Journal of Medical Physics
https://www.readbyqxmd.com/read/28134257/a-quantized-mechanism-for-activation-of-pannexin-channels
#4
Yu-Hsin Chiu, Xueyao Jin, Christopher B Medina, Susan A Leonhardt, Volker Kiessling, Brad C Bennett, Shaofang Shu, Lukas K Tamm, Mark Yeager, Kodi S Ravichandran, Douglas A Bayliss
Pannexin 1 (PANX1) subunits form oligomeric plasma membrane channels that mediate nucleotide release for purinergic signalling, which is involved in diverse physiological processes such as apoptosis, inflammation, blood pressure regulation, and cancer progression and metastasis. Here we explore the mechanistic basis for PANX1 activation by using wild type and engineered concatemeric channels. We find that PANX1 activation involves sequential stepwise sojourns through multiple discrete open states, each with unique channel gating and conductance properties that reflect contributions of the individual subunits of the hexamer...
January 30, 2017: Nature Communications
https://www.readbyqxmd.com/read/28067178/histone-deacetylase-inhibitors-for-the-treatment-of-colorectal-cancer-recent-progress-and-future-prospects
#5
Avineesh Singh, Preeti Patel, Vijay K Patel, Deepak K Jain, Ravichandran Veerasamy, Prabodh C Sharma, Harish Rajak
Colorectal cancer is a devastating disease with a dismal prognosis which is heavily hampered by delayed diagnosis. Surgical resection, radiation therapy and chemotherapy are the curative options. Due to few therapeutic treatments available i.e., mono and combination therapy and development of resistance towards drug response, novel and efficacious therapy is urgently needed. Histone deacetylase inhibitors (HDACIs) are emerging class of therapeutic agents having potential anticancer activity with minimal toxicity for different types of malignancies in preclinical studies...
January 9, 2017: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/27992822/thrombolytic-treatment-to-stroke-mimic-patients-via-telestroke
#6
Ganesh Asaithambi, Amy L Castle, Michael A Sperl, Jayashree Ravichandran, Aditi Gupta, Bridget M Ho, Sandra K Hanson
OBJECTIVE: The safety and outcomes of intravenous thrombolysis (IVT) to stroke patients via telestroke (TS) is similar to those presenting to stroke centers. Little is known on the accuracy of TS diagnosis among those receiving IVT. We sought to compare the rate of patients receiving IVT with diagnosis of ischemic stroke as opposed to stroke mimic (SM) in our TS network to those who presented to our comprehensive stroke center (CSC). MATERIALS AND METHODS: Consecutive patients receiving IVT between August 2014 and June 2015 were identified at our CSC and TS network...
February 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/27801785/novel-conopeptides-of-largely-unexplored-indo-pacific-conus-sp
#7
Eline K M Lebbe, Maarten G K Ghequire, Steve Peigneur, Bea G Mille, Prabha Devi, Samuthirapandian Ravichandran, Etienne Waelkens, Lisette D'Souza, René De Mot, Jan Tytgat
Cone snails are predatory creatures using venom as a weapon for prey capture and defense. Since this venom is neurotoxic, the venom gland is considered as an enormous collection of pharmacologically interesting compounds having a broad spectrum of targets. As such, cone snail peptides represent an interesting treasure for drug development. Here, we report five novel peptides isolated from the venom of Conus longurionis, Conus asiaticus and Conus australis. Lo6/7a and Lo6/7b were retrieved from C. longurionis and have a cysteine framework VI/VII...
October 27, 2016: Marine Drugs
https://www.readbyqxmd.com/read/27792666/ambipolar-transport-and-magneto-resistance-crossover-in-a-mott-insulator-sr2iro4
#8
J Ravichandran, C R Serrao, D K Efetov, D Yi, Y S Oh, S-W Cheong, R Ramesh, P Kim
Electric field effect (EFE) controlled magnetoelectric transport in thin films of undoped and La-doped Sr2IrO4 (SIO) is investigated using ionic liquid gating. The temperature dependent resistance measurements exhibit insulating behavior in chemically and EFE doped samples with the band filling up to 10%. The ambipolar transport across the Mott gap is demonstrated by EFE tuning of the channel resistance and chemical doping. We observe a crossover from high temperature negative to low temperature positive magnetoresistance around  ∼80-90 K, irrespective of the filling...
October 28, 2016: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/27760110/corrigendum-design-of-a-hyperstable-60-subunit-protein-icosahedron
#9
Yang Hsia, Jacob B Bale, Shane Gonen, Dan Shi, William Sheffler, Kimberly K Fong, Una Nattermann, Chunfu Xu, Po-Ssu Huang, Rashmi Ravichandran, Sue Yi, Trisha N Davis, Tamir Gonen, Neil P King, David Baker
No abstract text is available yet for this article.
December 1, 2016: Nature
https://www.readbyqxmd.com/read/27530008/aerobic-fitness-heart-rate-recovery-and-heart-rate-recovery-time-in-indian-school-children
#10
RANDOMIZED CONTROLLED TRIAL
Rajesh Jeniton Fernando, K Ravichandran, Mario Vaz
Data on aerobic fitness and heart rate recovery in children are limited. This study was done to evaluate the relation between them in Indian school going children. Three hundred children of 7 to 10.5 years were recruited and their aerobic fitness was predicted using modified Harvard's step test (VO₂max) and 20 meter shuttle test (VO₂peak). The heart rate was monitored for 12 minutes post modified Harvard's step test. The difference between the maximum and the 1st minute HR was noted as HRR1 and the time taken to reach the resting heart rate was also recorded...
October 2015: Indian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/27527120/in-vitro-cyclic-compressive-loads-potentiate-early-osteogenic-events-in-engineered-bone-tissue
#11
Akhilandeshwari Ravichandran, Jing Lim, Mark Seow Khoon Chong, Feng Wen, Yuchun Liu, Yaesshna T Pillay, Jerry K Y Chan, Swee-Hin Teoh
Application of dynamic mechanical loads on bone and bone explants has been reported to enhance osteogenesis and mineralization. To date, published studies have incorporated a range of cyclic strains on 3D scaffolds and platforms to demonstrate the effect of mechanical loading on osteogenesis. However, most of the loading parameters used in these studies do not emulate the in vivo loading conditions. In addition, the scaffolds/platforms are not representative of the native osteoinductive environment of bone tissue and hence may not be entirely accurate to study the in vivo mechanical loading...
August 16, 2016: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/27487787/pharmacophore-based-3d-qsar-virtual-screening-and-docking-studies-on-novel-series-of-hdac-inhibitors-with-thiophen-linker-as-anticancer-agents
#12
Preeti Patel, Avineesh Singh, Vijay K Patel, Deepak K Jain, Ravichandran Veerasamy, Harish Rajak
BACKGROUND: Histone deacetylase (HDAC) inhibitors can reactivate gene expression and inhibit the growth and survival of cancer cells. OBJECTIVE: To identify the important pharmacophoric features and correlate 3Dchemical structure with biological activity using 3D-QSAR and Pharmacophore modeling studies. METHOD: The pharmacophore hypotheses were developed using e-pharmacophore script and phase module. Pharmacophore hypothesis represents the 3D arrangement of molecular features necessary for activity...
2016: Combinatorial Chemistry & High Throughput Screening
https://www.readbyqxmd.com/read/27309817/design-of-a-hyperstable-60-subunit-protein-icosahedron
#13
Yang Hsia, Jacob B Bale, Shane Gonen, Dan Shi, William Sheffler, Kimberly K Fong, Una Nattermann, Chunfu Xu, Po-Ssu Huang, Rashmi Ravichandran, Sue Yi, Trisha N Davis, Tamir Gonen, Neil P King, David Baker
The icosahedron is the largest of the Platonic solids, and icosahedral protein structures are widely used in biological systems for packaging and transport. There has been considerable interest in repurposing such structures for applications ranging from targeted delivery to multivalent immunogen presentation. The ability to design proteins that self-assemble into precisely specified, highly ordered icosahedral structures would open the door to a new generation of protein containers with properties custom-tailored to specific applications...
July 7, 2016: Nature
https://www.readbyqxmd.com/read/27266708/higher-order-assemblies-of-oligomeric-cargo-receptor-complexes-form-the-membrane-scaffold-of-the-cvt-vesicle
#14
Chiara Bertipaglia, Sarah Schneider, Arjen J Jakobi, Abul K Tarafder, Yury S Bykov, Andrea Picco, Wanda Kukulski, Jan Kosinski, Wim Jh Hagen, Arvind C Ravichandran, Matthias Wilmanns, Marko Kaksonen, John Ag Briggs, Carsten Sachse
Selective autophagy is the mechanism by which large cargos are specifically sequestered for degradation. The structural details of cargo and receptor assembly giving rise to autophagic vesicles remain to be elucidated. We utilize the yeast cytoplasm-to-vacuole targeting (Cvt) pathway, a prototype of selective autophagy, together with a multi-scale analysis approach to study the molecular structure of Cvt vesicles. We report the oligomeric nature of the major Cvt cargo Ape1 with a combined 2.8 Å X-ray and negative stain EM structure, as well as the secondary cargo Ams1 with a 6...
July 2016: EMBO Reports
https://www.readbyqxmd.com/read/27111453/development-and-characterization-of-organic-electronic-scaffolds-for-bone-tissue-engineering
#15
Donata Iandolo, Akhilandeshwari Ravichandran, Xianjie Liu, Feng Wen, Jerry K Y Chan, Magnus Berggren, Swee-Hin Teoh, Daniel T Simon
Bones have been shown to exhibit piezoelectric properties, generating electrical potential upon mechanical deformation and responding to electrical stimulation with the generation of mechanical stress. Thus, the effects of electrical stimulation on bone tissue engineering have been extensively studied. However, in bone regeneration applications, only few studies have focused on the use of electroactive 3D biodegradable scaffolds at the interphase with stem cells. Here a method is described to combine the bone regeneration capabilities of 3D-printed macroporous medical grade polycaprolactone (PCL) scaffolds with the electrical and electrochemical capabilities of the conducting polymer poly(3,4-ethylenedioxythiophene) (PEDOT)...
June 2016: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/27090639/cystatin-e-m-suppresses-tumor-cell-growth-through-cytoplasmic-retention-of-nf-%C3%AE%C2%BAb
#16
Hendrick Soh, Natarajan Venkatesan, Mysore S Veena, Sandhiya Ravichandran, Alborz Zinabadi, Saroj K Basak, Kislay Parvatiyar, Meera Srivastava, Li-Jung Liang, David W Gjertson, Jorge Z Torres, Neda A Moatamed, Eri S Srivatsan
We and others have shown that the cystatin E/M gene is inactivated in primary human tumors, pointing to its role as a tumor suppressor gene. However, the molecular mechanism of tumor suppression is not yet understood. Using plasmid-directed cystatin E/M gene overexpression, a lentivirus-mediated tetracycline-inducible vector system, and human papillomavirus 16 (HPV 16) E6 and E7 gene-immortalized normal human epidermal keratinocytes, we demonstrated intracellular and non-cell-autonomous apoptotic growth inhibition of tumor cell lines and that growth inhibition is associated with cytoplasmic retention of NF-κB...
June 15, 2016: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/27087460/mayo-myriad-america-invents-act-and-bpcia-how-has-the-united-states-biopharmaceutical-market-been-affected
#17
Susan K Finston, Neil S Davey, Elina Davé, Varsha Ravichandran, Sonya R Davey, Raj S Davé
This paper discusses how the United States biopharmaceutical market has been affected by recent changes in patent law resulting from United States legislations (Biologics Price Competition and Innovation Act and the Leahy-Smith America Invents Act) and Supreme Court precedents (Mayo Collaborative Services v. Prometheus Laboratories, Inc. and Molecular Pathology v. Myriad Genetics). The authors interviewed eight key opinion leaders from the United States knowledgeable in biopharmaceuticals, including industry veterans, patent counsel, senior scientists and jurists...
May 2016: Pharmaceutical Patent Analyst
https://www.readbyqxmd.com/read/27063392/drug-design-strategies-for-the-discovery-of-novel-anticonvulsants-concerned-with-four-site-binding-pharmacophoric-model-studies
#18
Deepak K Jain, Avineesh Singh, Vijay K Patel, Ravichandran Veerasamy, Navneet Aggarwal, Harish Rajak
Anticonvulsant refers to a group of pharmaceuticals used in the treatment of epileptic seizures. The use of current antiepileptic drugs has been questioned due to the non-selectivity of the drugs and the undesirable side effects produced by them. This led to the search for antiepileptic compounds with more selectivity and lower toxicity. Semicarbazones have been developed as versatile anticonvulsant pharmacophore. It has displayed potent anticonvulsant effect in a wide variety of preclinical anticonvulsant models...
April 11, 2016: Central Nervous System Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/27037190/boosting-apoptotic-cell-clearance-by-colonic-epithelial-cells-attenuates-inflammation-in-vivo
#19
Chang Sup Lee, Kristen K Penberthy, Karen M Wheeler, Ignacio J Juncadella, Peter Vandenabeele, Jeffrey J Lysiak, Kodi S Ravichandran
Few apoptotic corpses are seen even in tissues with high cellular turnover, leading to the notion that the capacity for engulfment in vivo is vast. Whether corpse clearance can be enhanced in vivo for potential benefit is not known. In a colonic inflammation model, we noted that the expression of the phagocytic receptor Bai1 was progressively downmodulated. Consistent with this, BAI1-deficient mice had more pronounced colitis and lower survival, with many uncleared apoptotic corpses and inflammatory cytokines within the colonic epithelium...
April 19, 2016: Immunity
https://www.readbyqxmd.com/read/27026153/novel-pyrimidine-based-semicarbazones-confirmation-of-four-binding-site-pharmacophoric-model-hypothesis-for-antiepileptic-activity
#20
Harish Rajak, Deepak K Jain, Swati Singh, Avineesh Singh, Vijay K Patel, Ravichandran Veerasamy, Rajesh S Pawar
BACKGROUND: Epilepsy is a neurological disorder, characterized by seizures accompanied by loss or disturbance of consciousness affecting various physical and mental functions. Current anticonvulsant drugs are effective in controlling seizures in about 70% of cases, but their use is often limited by side effects like ataxia, megaloblastic anemia, hepatic failure. In search for a novel anticovulsant drug with better efficacy and lower toxicity, a series of novel pyrimidine based semicarbazone were designed and evaluated for antiepileptic activity...
March 30, 2016: Central Nervous System Agents in Medicinal Chemistry
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