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https://www.readbyqxmd.com/read/29745255/pannexin-1-channels-on-endothelial-cells-mediate-vascular-inflammation-during-lung-ischemia-reperfusion-injury
#1
Ashish K Sharma, Eric J Charles, Yunge Zhao, Adishesh K Narahari, Pranav K Baderdinni, Miranda E Good, Ulrike M Lorenz, Irving L Kron, Douglas A Bayliss, Kodi S Ravichandran, Brant E Isakson, Victor E Laubach
Ischemia-reperfusion injury (IRI), which involves inflammation, vascular permeability, and edema, remains a major challenge after lung transplantation. Pannexin 1 (Panx1) channels modulate cellular ATP release during inflammation. This study tests the hypothesis that endothelial Panx1 is a key mediator of vascular inflammation and edema after IR and that IRI can be blocked by Panx1 antagonism. A murine hilar ligation model of IRI was utilized whereby left lungs underwent 1 hour of ischemia and 2 hours of reperfusion...
May 10, 2018: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/29741882/identification-and-structure-activity-relationship-of-hdac6-zinc-finger-ubiquitin-binding-domain-inhibitors
#2
Renato Ferreira de Freitas, Rachel J Harding, Ivan Franzoni, Mani Ravichandran, Mandeep K Mann, Hui Ouyang, Mark Lautens, Vijayaratnam Santhakumar, Cheryl H Arrowsmith, Matthieu Schapira
HDAC6 plays a central role in the recruitment of protein aggregates for lysosomal degradation and is a promising target for combination therapy with proteasome inhibitors in multiple myeloma. Pharmacologically displacing ubiquitin from the zinc-finger ubiquitin-binding domain (ZnF-UBD) of HDAC6 is an underexplored alternative to catalytic inhibition. Here, we present the discovery of an HDAC6 ZnF-UBD-focused chemical series and its progression from virtual screening hits to low micromolar inhibitors. A carboxylate mimicking the C-terminal extremity of ubiquitin, and an extended aromatic system stacking with W1182 and R1155, are necessary for activity...
May 9, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29690020/redescription-of-parilia-alcocki-wood-mason-in-wood-mason-alcock-1891-decapoda-brachyura-leucosiidae-from-southeast-india
#3
M Prema, S Ravichandran, Peter K L Ng
Parilia alcocki Wood-Mason, in Wood-Mason Alcock, 1891, the type species of Parilia Wood-Mason, in Wood-Mason Alcock, 1891, described from the Bay of Bengal, is one of the largest known leucosioid crabs, reaching carapace widths of over 50 mm. It is, however, not well known and its male gonopods have never been figured. A series of specimens of this species obtained from a fishing port in Tamil Nadu, India, allows for a comprehensive re-description and illustrations of the species. Its distinguishing characters from congeners are discussed...
February 7, 2018: Zootaxa
https://www.readbyqxmd.com/read/29506128/prospective-evaluation-of-germline-alterations-in-patients-with-exocrine-pancreatic-neoplasms
#4
Maeve A Lowery, Winston Wong, Emmet J Jordan, Jonathan W Lee, Yelena Kemel, Joseph Vijai, Diana Mandelker, Ahmet Zehir, Marinela Capanu, Erin Salo-Mullen, Angela G Arnold, Kenneth H Yu, Anna M Varghese, David P Kelsen, Robin Brenner, Erica Kaufmann, Vignesh Ravichandran, Semanti Mukherjee, Michael F Berger, David M Hyman, David S Klimstra, Ghassan K Abou-Alfa, Catherine Tjan, Christina Covington, Hannah Maynard, Peter J Allen, Gokce Askan, Steven D Leach, Christine A Iacobuzio-Donahue, Mark E Robson, Kenneth Offit, Zsofia K Stadler, Eileen M O'Reilly
Background: Identification of pathogenic germline alterations (PGAs) has important clinical and therapeutic implications in pancreas cancer. We performed comprehensive germline testing (GT) in an unselected prospective cohort of patients with exocrine pancreatic neoplasms with genotype and phenotype association to facilitate identification of prognostic and/or predictive biomarkers and examine potential therapeutic implications. Methods: Six hundred fifteen unselected patients with exocrine pancreatic neoplasms were prospectively consented for somatic tumor and matched sample profiling for 410-468 genes...
February 28, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29458681/broad-neutralization-response-in-a-subset-of-hiv-1-subtype-c-infected-viraemic-non-progressors-from-southern-india
#5
Paneerselvam Nandagopal, Jayanta Bhattacharya, Aylur K Srikrishnan, Rajat Goyal, Chinnambedu Ravichandran Swathirajan, Shilpa Patil, Shanmugam Saravanan, Suprit Deshpande, Ramachandran Vignesh, Sunil Suhas Solomon, Nikhil Singla, Joyeeta Mukherjee, Kailapuri G Murugavel
Broadly neutralizing antibodies (bnAbs) have been considered to be potent therapeutic tools and potential vaccine candidates to enable protection against various clades of human immunodeficiency virus (HIV). The generation of bnAbs has been associated with enhanced exposure to antigen, high viral load and low CD4+ T cell counts, among other factors. However, only limited data are available on the generation of bnAbs in viraemic non-progressors that demonstrate moderate to high viraemia. Further, since HIV-1 subtype C viruses account for more than 50 % of global HIV infections, the identification of bnAbs with novel specificities is crucial to enable the development of potent tools to aid in HIV therapy and prevention...
February 5, 2018: Journal of General Virology
https://www.readbyqxmd.com/read/29454661/rethinking-phagocytes-clues-from-the-retina-and-testes
#6
REVIEW
Kristen K Penberthy, Jeffrey J Lysiak, Kodi S Ravichandran
Specialized phagocytes are a newly appreciated classification of phagocyte that currently encompasses Sertoli cells (SCs) of the testes and the retinal pigment epithelial cells (RPE) of the retina. While these cells support very different tissues, they have a striking degree of similarity both as phagocytes and in ways that go beyond cell clearance. The clearance of apoptotic germ cells, cell debris, and used photoreceptor outer segments are critical functions of these cells, and the unique nature of their clearance events make specialized phagocytes uniquely suited for studying the larger implications of cell clearance in vivo...
April 2018: Trends in Cell Biology
https://www.readbyqxmd.com/read/29430147/prosthetic-rehabilitation-in-neurosurgical-cranioplasty
#7
Thara Maria Joseph, R Ravichandran, K Harshakumar, S Lylajam
The defects of the skull cause mechanical vulnerability of the brain, esthetic disfigurement, and transmission of vibrations and pulsation of the brain. Subsequent cranioplasty may be required to compensate for the defect and to alleviate various signs and symptoms. When long-term outcome of biomaterial use in pediatric cases is limited, alloplastic cranioplasty in adults are supported by several large case series. This case report narrates cranioplasty using titanium alloplastic implant material.
January 2018: Journal of Indian Prosthodontic Society
https://www.readbyqxmd.com/read/29430135/a-comparative-evaluation-of-the-marginal-adaptation-of-a-thermoplastic-resin-a-light-cured-wax-and-an-inlay-casting-wax-on-stone-dies-an-in-vitro-study
#8
Reji P Gopalan, Vivek V Nair, K Harshakumar, R Ravichandran, S Lylajam, Prasanth Viswambaran
Background: Different pattern materials do not produce copings with satisfactory, marginal accuracy when used on stone dies at varying time intervals. Purpose: The purpose of this study was to evaluate and compare the vertical marginal accuracy of patterns formed from three materials, namely, thermoplastic resin, light cured wax and inlay casting wax at three-time intervals of 1, 12, and 24 h. Methodology: A master die (zirconia abutment mimicking a prepared permanent maxillary central incisor) and metal sleeve (direct metal laser sintering crown #11) were fabricated...
January 2018: Journal of Indian Prosthodontic Society
https://www.readbyqxmd.com/read/29364552/troubleshooting-electromagnetic-interference-in-a-patient-with-centrifugal-flow-left-ventricular-assist-device-and-subcutaneous-implantable-cardioverter-defibrillator
#9
Asim S Ahmed, Parin J Patel, Shiv Bagga, Jasen L Gilge, Thomas Schleeter, Baqir A Lakhani, Ashwin K Ravichandran, Steve Donnelley, Venu Allavatam, Eric N Prystowsky, Benzy J Padanilam
A 25-year-old man with severe nonischemic dilated cardiomyopathy underwent subcutaneous implantable cardioverter defibrillator (S-ICD) implant and subsequently underwent HeartWare ventricular assist device (HVAD) placement. Postoperative interrogation revealed both primary and secondary S-ICD vectors inappropriately regarded sinus rhythm as "noise," and the alternate vector significantly undersensed sinus rhythm. The S-ICD was reinterrogated using high-resolution capture to visually confirm EMI with a dominant frequency in both the primary and secondary vectors of 46...
March 2018: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/29314764/biomimetic-fetal-rotation-bioreactor-for-engineering-bone-tissues-effect-of-cyclic-strains-on-upregulation-of-osteogenic-gene-expression
#10
Akhilandeshwari Ravichandran, Feng Wen, Jing Lim, Mark Seow Khoon Chong, Jerry K Y Chan, Swee-Hin Teoh
Cells respond to physiological mechanical stresses especially during early fetal development. Adopting a biomimetic approach, it is necessary to develop bioreactor systems to explore the effects of physiologically relevant mechanical strains and shear stresses for functional tissue growth and development. This study introduces a multimodal bioreactor system that allows application of cyclic compressive strains on premature bone grafts that are cultured under biaxial rotation (chamber rotation about 2 axes) conditions for bone tissue engineering...
January 3, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29304844/the-uae-healthy-future-study-a-pilot-for-a-prospective-cohort-study-of-20-000-united-arab-emirates-nationals
#11
Abdishakur Abdulle, Abdullah Alnaeemi, Abdullah Aljunaibi, Abdulrahman Al Ali, Khaled Al Saedi, Eiman Al Zaabi, Naima Oumeziane, Marina Al Bastaki, Mohammed Al-Houqani, Fatma Al Maskari, Ayesha Al Dhaheri, Syed M Shah, Tom Loney, Mohamed El-Sadig, Abderrahim Oulhaj, Leila Abdel Wareth, Wael Al Mahmeed, Habiba Alsafar, Benjamin Hirsch, Fatme Al Anouti, Jamila Yaaqoub, Claire K Inman, Aisha Al Hamiz, Ayesha Al Hosani, Muna Haji, Teeb Alsharid, Thekra Al Zaabi, Fatima Al Maisary, Divya Galani, Tim Sprosen, Omar El Shahawy, Jiyoung Ahn, Tomas Kirchhoff, Ravichandran Ramasamy, Ann Marie Schmidt, Richard Hayes, Scott Sherman, Raghib Ali
BACKGROUND: The United Arab Emirates (UAE) is faced with a rapidly increasing burden of non-communicable diseases including obesity, diabetes, and cardiovascular disease. The UAE Healthy Future study is a prospective cohort designed to identify associations between risk factors and these diseases amongst Emiratis. The study will enroll 20,000 UAE nationals aged ≥18 years. Environmental and genetic risk factors will be characterized and participants will be followed for future disease events...
January 5, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29259282/analysis-of-killing-of-growing-cells-and-dormant-and-germinated-spores-of-bacillus-species-by-black-silicon-nanopillars
#12
Sonali Ghosh, Shanyuan Niu, Maya Yankova, Matthew Mecklenburg, Stephen M King, Jayakanth Ravichandran, Rajiv K Kalia, Aiichiro Nakano, Priya Vashishta, Peter Setlow
Black silicon (bSi) wafers with a high density of high-aspect ratio nanopillars have recently been suggested to have mechanical bactericidal activity. However, it remains unclear whether bSi with the nanopillars can kill only growing bacterial cells or also dormant spores that are harder to kill. We have reexamined the cidal activity of bSi on growing cells, dormant and germinated spores of B. subtilis, and dormant spores of several other Bacillus species by incubation on bSi wafers with and without nanopillars...
December 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29237722/pannexin-1-channels-as-an-unexpected-new-target-of-the-anti-hypertensive-drug-spironolactone
#13
Miranda E Good, Yu-Hsin Chiu, Ivan K H Poon, Christopher B Medina, Joshua T Butcher, Suresh K Mendu, Leon J DeLalio, Alexander W Lohman, Norbert Leitinger, Eugene Barrett, Ulrike M Lorenz, Bimal N Desai, Iris Z Jaffe, Douglas A Bayliss, Brant E Isakson, Kodi S Ravichandran
RATIONALE: Resistant hypertension is a major health concern with unknown cause. Spironolactone is an effective antihypertensive drug, especially for patients with resistant hypertension, and is considered by the World Health Organization as an essential medication. Although spironolactone can act at the mineralocorticoid receptor (MR; NR3C2), there is increasing evidence of MR-independent effects of spironolactone. OBJECTIVE: Here, we detail the unexpected discovery that Panx1 (pannexin 1) channels could be a relevant in vivo target of spironolactone...
February 16, 2018: Circulation Research
https://www.readbyqxmd.com/read/29210772/bleeding-complication-rates-are-higher-in-females-after-continuous-flow-left-ventricular-assist-device-implantation
#14
Zubin Yavar, Jennifer A Cowger, Sina L Moainie, Christopher T Salerno, Ashwin K Ravichandran
The aims of this analysis were to characterize the burden and timing of bleeding events in females versus males on left ventricular assist device (LVAD) support. A single-center retrospective review of 375 patients receiving continuous-flow LVADs was performed. Bleeding events included gastrointestinal, naso-oropharyngeal, gynecologic (GYN), intracranial hemorrhage (ICH), and mediastinal bleeding. Cox hazard ratios (HRs) [95% CI] and incident event rates for females versus males were calculated. Eighty-four females (22%) and 291 males (78%) received an LVAD...
November 27, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29204365/the-age-rage-axis-in-an-arab-population-the-united-arab-emirates-healthy-futures-uaehfs-pilot-study
#15
Claire K Inman, Abdullah Aljunaibi, Hyunwook Koh, Abdishakur Abdulle, Raghib Ali, Abdullah Alnaeemi, Eiman Al Zaabi, Naima Oumeziane, Marina Al Bastaki, Mohammed Al-Houqani, Fatma Al-Maskari, Ayesha Al Dhaheri, Syed M Shah, Laila Abdel Wareth, Wael Al Mahmeed, Habiba Alsafar, Fatme Al Anouti, Ayesha Al Hosani, Muna Haji, Divya Galani, Matthew J O'Connor, Jiyoung Ahn, Tomas Kirchhoff, Scott Sherman, Richard B Hayes, Huilin Li, Ravichandran Ramasamy, Ann Marie Schmidt
Aims: The transformation of the United Arab Emirates (UAE) from a semi-nomadic to a high income society has been accompanied by increasing rates of obesity and Type 2 diabetes mellitus. We examined if the AGE-RAGE (receptor for advanced glycation endproducts) axis is associated with obesity and diabetes mellitus in the pilot phase of the UAE Healthy Futures Study (UAEHFS). Methods: 517 Emirati subjects were enrolled and plasma/serum levels of AGE, carboxy methyl lysine (CML)-AGE, soluble (s)RAGE and endogenous secretory (es)RAGE were measured along with weight, height, waist and hip circumference (WC/HC), blood pressure, HbA1c, Vitamin D levels and routine chemistries...
December 2017: Journal of Clinical & Translational Endocrinology
https://www.readbyqxmd.com/read/29190082/pourbaix-diagram-proton-coupled-electron-transfer-and-decay-kinetics-of-a-protein-tryptophan-radical-comparing-the-redox-properties-of-w-32-%C3%A2-and-y-32-%C3%A2-generated-inside-the-structurally-characterized-%C3%AE-3-w-and-%C3%AE-3-y-proteins
#16
Starla D Glover, Robin Tyburski, Li Liang, Cecilia Tommos, Leif Hammarström
Protein-based "hole" hopping typically involves spatially arranged redox-active tryptophan or tyrosine residues. Thermodynamic information is scarce for this type of process. The well-structured α3 W model protein was studied by protein film square wave voltammetry and transient absorption spectroscopy to obtain a comprehensive thermodynamic and kinetic description of a buried tryptophan residue. A Pourbaix diagram, correlating thermodynamic potentials (E°') with pH, is reported for W32 in α3 W and compared to equivalent data recently presented for Y32 in α3 Y ( Ravichandran , K...
January 10, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29117042/impact-of-patient-distance-from-ventricular-assist-device-implanting-center-on-short-and-long-term-outcomes
#17
Ashwin K Ravichandran, Palak Shah, Ramesh Singh, Keith D Aaronson, Francis D Pagani, John Stulak, Shannon M Dunlay, Todd F Dardas, Nahush A Mokadam, Christopher T Salerno, Jennifer A Cowger
Highly specialized left ventricular assist device care is not readily available in many areas, potentially limiting access to therapy. This retrospective analysis examines the relationship of outcomes by patient distance from implanting left ventricular assist device center within the Mechanical Circulatory Support Research Network. Zip codes were used to calculate patient distance, with the primary outcome of interest being 3-year survival by distance from the surgical center. Secondary outcomes included 90-day survival and incident event rates for the following: gastrointestinal bleeding, infection, cerebral event, and pump thrombosis...
November 7, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29116131/context-dependent-compensation-among-phosphatidylserine-recognition-receptors
#18
Kristen K Penberthy, Claudia Rival, Laura S Shankman, Michael H Raymond, Jianye Zhang, Justin S A Perry, Chang Sup Lee, Claudia Z Han, Suna Onengut-Gumuscu, Krzysztof Palczewski, Jeffrey J Lysiak, Kodi S Ravichandran
Phagocytes express multiple phosphatidylserine (PtdSer) receptors that recognize apoptotic cells. It is unknown whether these receptors are interchangeable or if they play unique roles during cell clearance. Loss of the PtdSer receptor Mertk is associated with apoptotic corpse accumulation in the testes and degeneration of photoreceptors in the eye. Both phenotypes are linked to impaired phagocytosis by specialized phagocytes: Sertoli cells and the retinal pigmented epithelium (RPE). Here, we overexpressed the PtdSer receptor BAI1 in mice lacking MerTK (Mertk-/- Bai1Tg ) to evaluate PtdSer receptor compensation in vivo...
November 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29095736/outcomes-with-the-tandem-protek-duo-dual-lumen-percutaneous-right-ventricular-assist-device
#19
Ashwin K Ravichandran, David A Baran, Kelly Stelling, Jennifer A Cowger, Christopher T Salerno
Recently, a percutaneous right ventricular assist device (RVAD) called the TandemLife Protek Duo (TPD; TandemLife, Pittsburgh, PA) has been introduced. The Protek Duo (TPD) is a temporary RVAD placed via the right internal jugular vein, capable of providing up to 4.5 L of flow. We report a two-center experience using the TPD in 17 patients with right ventricular (RV) failure, 12 of whom were post-left ventricular assist device (LVAD) implantation.
October 31, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29064668/real-time-observation-of-exciton-phonon-coupling-dynamics-in-self-assembled-hybrid-perovskite-quantum-wells
#20
Limeng Ni, Uyen Huynh, Alexandre Cheminal, Tudor H Thomas, Ravichandran Shivanna, Ture F Hinrichsen, Shahab Ahmad, Aditya Sadhanala, Akshay Rao
Self-assembled hybrid perovskite quantum wells have attracted attention due to their tunable emission properties, ease of fabrication, and device integration. However, the dynamics of excitons in these materials, especially how they couple to phonons, remains an open question. Here, we investigate two widely used materials, namely, butylammonium lead iodide (CH3 (CH2 )3 NH3 )2 PbI4 and hexylammonium lead iodide (CH3 (CH2 )5 NH3 )2 PbI4 , both of which exhibit broad photoluminescence tails at room temperature...
November 28, 2017: ACS Nano
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