Roua Hassoun, Heidi Budde, Saltanat Zhazykbayeva, Melissa Herwig, Marcel Sieme, Simin Delalat, Nusratul Mostafi, Kamilla Gömöri, Melina Tangos, Muhammad Jarkas, Steffen Pabel, Stefanie Bruckmüller, Marina Skrygan, Mária Lódi, Kornelia Jaquet, Vasco Sequeira, Thilo Gambichler, Cris Dos Remedios, Árpád Kovács, Hans Georg Mannherz, Andreas Mügge, Samuel Sossalla, Nazha Hamdani
Hypertrophic cardiomyopathy (HCM) is a complex myocardial disorder with no well-established disease-modifying therapy so far. Our study aimed to investigate how autophagy, oxidative stress, inflammation, stress signalling pathways, and apoptosis are hallmark of HCM and their contribution to the cardiac dysfunction. Demembranated cardiomyocytes from patients with HCM display increased titin-based stiffness (Fpassive ), which was corrected upon antioxidant treatment. Titin as a main determinant of Fpassive was S-glutathionylated and highly ubiquitinated in HCM patients...
December 1, 2021: International Journal of Cardiology