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Fibromuscular dysplasia carotid

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https://www.readbyqxmd.com/read/27854110/association-between-carotid-artery-tortuosity-and-carotid-dissection-a-case-control-study
#1
Sarasa T Kim, Waleed Brinjikji, Vance T Lehman, Carrie M Carr, Patrick H Luetmer, Charlotte H Rydberg
BACKGROUND: Carotid artery dissections have long been associated with compromise of the structural integrity of the arterial wall from heritable connective-tissue disorders, hypertension, and trauma. However, an association between spontaneous internal carotid artery dissection and tortuous or redundant carotid anatomy has not been fully explored. METHODS: Patients with CTA confirmed spontaneous cervical internal carotid artery dissections were compared to a group of age and sex matched controls who also received CTA of the neck...
November 17, 2016: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/27827286/-hypertension-due-to-fibromuscular-dysplasia-look-for-additional-disease-sites
#2
M L Maas, J M Kroese, S J H Bredie, C T Postma, F E de Leeuw, L J Schultze Kool, N P Riksen
Fibromuscular dysplasia (FMD) is a non-inflammatory, non-atherosclerotic vasculopathy that can lead to arterial stenosis, occlusion, aneurysms, and dissection. FMD of the renal arteries can lead to renovascular hypertension. Percutaneous angioplasty of the renal arteries (PTRA) can lead to normalization of blood pressure in 45% of patients with renal artery stenosis caused by FMD, particularly in younger patients and patients with a short history of hypertension. A considerable number of the patients with renovascular FMD also have cervical FMD, which can lead to ischaemic or haemorrhagic stroke...
2016: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/27792790/phactr1-is-a-genetic-susceptibility-locus-for-fibromuscular-dysplasia-supporting-its-complex-genetic-pattern-of-inheritance
#3
Soto Romuald Kiando, Nathan R Tucker, Luis-Jaime Castro-Vega, Alexander Katz, Valentina D'Escamard, Cyrielle Tréard, Daniel Fraher, Juliette Albuisson, Daniella Kadian-Dodov, Zi Ye, Erin Austin, Min-Lee Yang, Kristina Hunker, Cristina Barlassina, Daniele Cusi, Pilar Galan, Jean-Philippe Empana, Xavier Jouven, Anne-Paule Gimenez-Roqueplo, Patrick Bruneval, Esther Soo Hyun Kim, Jeffrey W Olin, Heather L Gornik, Michel Azizi, Pierre-François Plouin, Patrick T Ellinor, Iftikhar J Kullo, David J Milan, Santhi K Ganesh, Pierre Boutouyrie, Jason C Kovacic, Xavier Jeunemaitre, Nabila Bouatia-Naji
Fibromuscular dysplasia (FMD) is a nonatherosclerotic vascular disease leading to stenosis, dissection and aneurysm affecting mainly the renal and cerebrovascular arteries. FMD is often an underdiagnosed cause of hypertension and stroke, has higher prevalence in females (~80%) but its pathophysiology is unclear. We analyzed ~26K common variants (MAF>0.05) generated by exome-chip arrays in 249 FMD patients and 689 controls. We replicated 13 loci (P<10-4) in 402 cases and 2,537 controls and confirmed an association between FMD and a variant in the phosphatase and actin regulator 1 gene (PHACTR1)...
October 2016: PLoS Genetics
https://www.readbyqxmd.com/read/27790125/a-case-of-turner-syndrome-with-multiple-embolic-infarcts
#4
Cindy W Yoon, Eungseok Lee, Byung-Nam Yoon, Hee-Kwon Park, Joung-Ho Rha
Only a few cases of Turner syndrome (TS) with ischemic stroke have been reported. Various arteriopathies of the cerebral arteries, including fibromuscular dysplasia, congenital hypoplasia, moyamoya syndrome, and premature atherosclerosis have been assumed to be the cause of ischemic stroke in TS. There has been no case report of a TS patient presenting with an embolic stroke pattern without any cerebral arteriopathy. A 28-year-old woman with TS was referred to our hospital because of abnormal brain magnetic resonance imaging (MRI) findings...
September 2016: Case Reports in Neurology
https://www.readbyqxmd.com/read/27781048/internal-carotid-artery-s-shaped-curve-as-a-marker-of-fibromuscular-dysplasia-in-dissection-related-acute-ischemic-stroke
#5
Diogo C Haussen, Ashutosh Jadhav, Leticia C Rebello, Samir Belagaje, Aaron Anderson, Tudor Jovin, Amin Aghaebrahim, Deepak Gulati, Bryan Wells, Michael Frankel, Raul G Nogueira
BACKGROUND AND PURPOSE: Craniocervical fibromuscular dysplasia (FMD) is associated with dissections and with S-shaped curves in the internal carotid artery (ICA). We evaluated the occurrence of S-curves in patients presenting with acute strokes due to ICA steno-occlusive dissections. METHODS: This was a retrospective review of the interventional databases of two academic tertiary-care institutions. The presence of ICA S-shaped curves, C-shaped curves, 360-degree loops, as well as classic FMD and atherosclerotic changes at the ICA bulb and curve/loop was determined...
September 2016: Interventional Neurology
https://www.readbyqxmd.com/read/27512536/endovascular-treatment-of-renal-artery-stenosis-due-to-fibromuscular-dysplasia-is-stent-implantation-underused-in-this-circumstance
#6
Efe Edem, Murat Necati Aksoy, Mustafa Türker Pabuccu, Ersan Tatlı
Fibromuscular dysplasia (FMD) is a nonatherosclerotic and noninflammatory arterial disease that commonly affects the renal and carotid arteries. The primary target in treating patients with renal artery FMD is the control of blood pressure in order to prevent end-organ damage, which can be caused by poorly controlled hypertension. Invasive endovascular treatment should be taken into consideration both when hypertension cannot be controlled with medication. According to current opinion, hypertension attributed to renal artery FMD is often successfully treated solely with percutaneous renal balloon angioplasty (PRBA), with no requirement for stent implantation under most circumstances...
April 2016: Heart Views: the Official Journal of the Gulf Heart Association
https://www.readbyqxmd.com/read/27508836/-op-7c-04-genetic-association-study-identifies-common-variation-in-phactr1-to-associate-with-fibromuscular-dysplasia
#7
S Kiando, N Tucker, L Castro-Vega, D Cusi, P Galan, Empana J-P, J Olin, H Gornik, P-F Plouin, I Kullo, D Milan, S Ganesh, P Boutouyrie, J Kovacic, X Jeunemaitre, N Bouatia-Naji
OBJECTIVE: Fibromuscular dysplasia (FMD) is a nonatherosclerotic vascular disease leading to stenosis, dissection and aneurysm affecting mainly the renal and cerebrovascular arteries. FMD has higher prevalence in females (80-90%) and predisposes to hypertension and stroke but its pathophysiology is unclear. DESIGN AND METHOD: We performed a multistage genetic association study (1,154 patients and 3,895 controls) from five case-control cohorts. We investigated the association between rs9349379 in the phosphatase and actin regulator 1 gene (PHACTR1) and carotid traits by echo-tracking in healthy volunteers, the expression of PHACTR1 by genotypes in human fibroblasts, protein staining pattern in human carotids, and vasculature development after Phactr1 knockdown in zebrafish...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27508830/-op-1c-05-the-polish-registry-for-fibromuscular-dysplasia-the-preliminary-report-on-distribution-of-vascular-bed-involvement-and-complications-in-patients-enrolled-in-arcadia-pol-study
#8
E Warchol-Celinska, K Hanus, P Talarowska, E Florczak, K Jozwik-Plebanek, M Januszewicz, I Michalowska, A Prejbisz, W Wojcik, H Janaszek-Sitkowska, M Makowiecka-Ciesla, L Stryczynski, M Protasiewicz, L Swiatlowski, A Niemirska, M Litwitn, T Przewlocki, M Szczerbo-Trojanowska, A Tykarski, A Januszewicz
OBJECTIVE: To present preliminary evaluation of vascular bed involvement and vascular complications in patients with fibromuscular dysplasia (FMD) enrolled to ARCADIA-POL registry. DESIGN AND METHOD: The first 84 patients (59F[70.2%], 25M[29.8%], mean age: 42.5 ± 14.8 years, range:18-72) with confirmed FMD in any vascular bed were enrolled in 2015 in ARCADIA-POL registry (instituted on the basis of as Polish-French collaboration). A standardized FMD data form was used for data collection...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27508805/-op-1c-04-structural-and-functional-arterial-abnormalities-in-fibromuscular-dysplasia-are-in-the-continuum-of-hypertension-an-imaging-and-biomechanical-study
#9
L Marais, P Boutouyrie, H Khettab, C Boulanger, A Lorthiroir, M Frank, R Niarra, J Renard, Y Chambon, X Jeunemaitre, M Zidi, P-F Plouin, S Laurent, M Azizi
OBJECTIVE: Fibromuscular dysplasia (FMD) is a non-atherosclerotic non-inflammatory arterial disease, which occurs mostly in middle-aged women and affects medium-sized arteries. We previously showed abnormalities within common carotid artery (CCA) wall, with the presence of triple signal (TS) at ultrasound suggesting the presence of supplementary layers. We aimed at coupling TS presence with microconstituents of the vessel wall, derived from fitting of the pressure-diameter curve. DESIGN AND METHOD: We included 50 non-smoking patients with multifocal FMD, 50 essential hypertensive (EH) patients and 50 healthy subjects (HS) matched for age, sex, ethnicity and BP (EH and FD)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27508731/-op-5a-04-evaluation-of-retinal-microperfusion-and-arteriolar-structure-in-patients-with-fibromuscular-dysplasia-the-preliminary-data-of-the-polish-registry-for-fibromuscular-dysplasia
#10
E Warchol-Celinska, M Gosk-Przybylek, J Harazny, E Binczyk, K Szymanek, K Hanus, K Jozwik-Plebanek, E Florczak, A Prejbisz, I Cendrowska-Demkow, P Dobrowolski, A Klisiewicz, I Kurkowska-Jastrzebska, B Blazejewska-Hyzorek, M Januszewicz, I Michalowska, J P Szaflik, R E Schmieder, J Szaflik, A Januszewicz
OBJECTIVE: To compare retinal microperfusion and arteriolal structure between patients with fibromuscular dysplasia (FMD) enrolled to the ARCADIA-POL registry and patients with essential hypertension (EHT). DESIGN AND METHOD: From the first 84 patients with confirmed FMD in any vascular bed enrolled in the ARCADIA-POL registry in 2015 (instituted on the basis of as Polish-French collaboration), we analyzed data regarding retinal microperfusion and arteriolar structure available from 70 patients (51F, 19 M, mean age: 41...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27504335/resistant-hypertension-due-to-fibromuscular-dysplasia-in-a-young-male-a-rare-case-report
#11
Hossein Vakili, Isa Khaheshi, Mehdi Memaryan, Roxana Sadeghi, Mohammadreza Naderian
Fibromuscular Dysplasia (FMD) is a sporadic non-atherosclerotic disease. FMD has been established in nearly every arterial bed. However, the most frequent arteries affected are the renal and carotid arteries. Disease presentation may vary broadly, depending upon the arterial bed complication and the severity of illness. Hypertension, particularly resistant type, headache and dizziness are the most common presentations. String of beads appearance in angiographic views due to post-stenotic aneurysms is the characteristic view...
June 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27492650/a-wide-necked-extracranial-internal-carotid-artery-saccular-aneurysm-with-ipsilateral-proximal-compression
#12
ChunXiang Jin, ZhenZhen Hu, Yu He
Extracranial internal carotid artery aneurysms (EICAA) are rare and can elicit various neurologic symptoms. Here, we present a case of a saccular EICAA compressing its proximal parent internal carotid artery (ICA). Ultrasonography demonstrated the proximal ICA stenosis and the "tardus-parvus" Doppler waveform downstream. The patient underwent aneurysmectomy and graft interposition. The histologic analysis highly supported an atypical fibromuscular dysplasia. Although this patient only showed a neck mass, the reduced ipsilateral cerebral blood supply was a potential cause for neurologic symptoms...
August 5, 2016: Journal of Clinical Ultrasound: JCU
https://www.readbyqxmd.com/read/27487739/mesenteric-arteriovenous-dysplasia-vasculopathy-is-distinct-from-fibromuscular-dysplasia
#13
Deepa T Patil, Juliana Kissiedu, E Rene Rodriguez, Erinn Downs-Kelly, Xiuli Liu, Lisa A Rybicki, Carmela D Tan
Fibromuscular dysplasia (FMD) is a noninflammatory, nonatherosclerotic vasculopathy that usually affects the carotid and renal arteries. We have observed FMD-like vascular changes in specimens resected for ischemia or Crohn's disease (CD). On the basis of a systematic clinicopathologic review of these 11 cases identified between 1982 and 2014, we describe a distinct mesenteric vasculopathy that involves both arteries and veins [mesenteric arteriovenous dysplasia/vasculopathy (MAVD/V)] and is characterized by (1) concentric/eccentric smooth muscle collarette around the tunica media of both the artery and the vein in ≥2 foci, (2) varying degrees of intimal and medial hyperplasia and adventitial fibrosis, and (3) lack of inflammation or thrombi...
October 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27386771/dissection-and-aneurysm-in-patients-with%C3%A2-fibromuscular-dysplasia-findings-from-the-u-s-registry-for-fmd
#14
Daniella Kadian-Dodov, Heather L Gornik, Xiaokui Gu, James Froehlich, J Michael Bacharach, Yung-Wei Chi, Bruce H Gray, Michael R Jaff, Esther S H Kim, Pamela Mace, Aditya Sharma, Eva Kline-Rogers, Christopher White, Jeffrey W Olin
BACKGROUND: Fibromuscular dysplasia (FMD) is a noninflammatory arterial disease that predominantly affects women. The arterial manifestations may include beading, stenosis, aneurysm, dissection, or tortuosity. OBJECTIVES: This study compared the frequency, location, and outcomes of FMD patients with aneurysm and/or dissection to those of patients without. METHODS: The U.S. Registry for FMD involves 12 clinical centers. This analysis included clinical history, diagnostic, and therapeutic procedure results for 921 FMD patients enrolled in the registry as of October 17, 2014...
July 12, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27384119/-a-case-of-fibromuscular-dysplasia-in-a-patient-with-various-main-trunk-dissections-in-the-head-and-neck-over-a-short-period
#15
Kazuhiro Ando, Osamu Sasaki, Masatoshi Watanabe, Takeo Nashimoto, Bumpei Kikuchi
We report a case of subarachnoid hemorrhage(SAH)from an intracranial vertebral artery(VA)dissection in a patient with fibromuscular dysplasia(FMD)who presented with headache. A 54-year-old woman complained of spontaneous occipital headache. The dilatation of the left VA was detected on magnetic resonance angiography(MRA). She was diagnosed with left VA dissection(headache onset type). After sudden onset of headache on the second day of hospitalization, her consciousness level, as defined by the Japan Coma Scale, was 300...
July 2016: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/27296003/-expression-of-matrix-metalloproteinases-and-their-inhibitors-in-the-internal-carotid-artery-wall-in-pathological-tortuosity
#16
E M Pal'tseva, V O Polyakova, S A Oskolkova, A V Abramyan, A G Ivanova, Yu S Krylova, A V Gavrilenko
UNLABELLED: The principal morphological sign of fibromuscular dysplasia in pathological tortuosity (PT) of the internal carotid artery (ICA) is the fragmentation of elastic fibers that are degraded by matrix metalloproteinases 2 and 9 (MMP-2, MMP-9). Nevertheless, the role of MMPs and their inhibitors in the pathogenesis of ICA PT remains completely unexplored. AIM: to investigate the expression of elastin-degrading MMPs and their inhibitors in the wall of the ICA in PT by immunohistochemistry and confocal laser scanning microscopy...
May 2016: Arkhiv Patologii
https://www.readbyqxmd.com/read/26978013/-the-structure-of-the-internal-carotid-artery-wall-in-pathological-tortuosity
#17
E M Paltseva, S A Oskolkova, V O Polyakova, Y U S Krylova, A G Ivanova, A V Abramyan, A V Gavrilenko
OBJECTIVE: to study a change in the content of main components of the internal carotid artery (ICA) wall in pathological tortuosity (PT) resulting from fibromuscular dysplasia, using immunohistochemistry and confocal laser scanning microscopy. MATERIAL AND METHODS: Immunohistochemical (IHC) analysis using antibodies to elastin, collagen types I and III, and smooth muscle actin was made. The levels of elastin and matrix metalloproteinase 9 (MMP-9) were determined by confocal laser scanning microscopy...
September 2015: Arkhiv Patologii
https://www.readbyqxmd.com/read/26968476/-fibromuscular-dysplasia-of-renal-arteries
#18
Pierre-François Plouin, Béatrice Fiquet, Guillaume Bobrie, Xavier Jeunemaître
Fibromuscular dysplasia is non-atherosclerotic, non-inflammatory disease of the medium caliber arteries causing segmental stenosis, and sometimes aneurysm and/or dissection. Renal involvement is either asymptomatic or revealed by hypertension, rarely acute complications (renal infarction/hemorrhage). Cross-sectional imaging or angiography differentiates multifocal fibromuscular dysplasia (pearl necklace appearance) and focal fibromuscular dysplasia (tubular stenosis). Several differential diagnoses are to be mentioned...
April 2016: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/26877297/co-43-genetic-study-identifies-common-variation-in-phactr1-to-associate-with-fibromuscular-dysplasia
#19
S Kiando, N Tucker, A Katz, C Tréard, V Desca-Mard, L Castro-Vega, C Barlasina, D Cusi, P Galan, J Empana, J Olin, H Gornik, P Plouin, I Kullo, D Milan, S Ganesh, P Boutouyrie, J Kovacic, X Jeunemaitre, N Bouatia-Naji
BACKGROUND: Fibromuscular dysplasia (FMD) is a nonatherosclerotic vascular disease leading to arterial stenosis, aneurysm and dissection, mainly in renal and carotid artery. FMD has higher prevalence in females (80-90%) and is associated with hypertension and stroke. The pathophysiology of FMD is unclear and a genetic origin is suspected. METHODS: We performed a genetic association study in European ancestry individuals. The discovery included 249 cases and 689 controls, in which we analyzed 25,606 common variants (MAF>0...
December 2015: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/26877282/co-29-carotid-artery-phenotyping-using-high-resolution-radiofrequency-based-echotracking-system-in-patients-with-multifocal-fibromuscular-dysplasia-across-sectional-study
#20
H Khettab, A Lorthioir, R Niarra, Y Chambon, X Jeunemaitre, P F Plouin, S Laurent, P Boutouyrie, M Azizi
BACKGROUND: Fibromuscular dysplasia (FD) is a rare idiopathic, segmental, non-atherosclerotic non-inflammatory vascular disease, which occurs mostly in middle-aged patients and affects medium-sized arteries (renal and carotid arteries). We previously showed that renal FD is associated with supernumerary echo interfaces (triple signal pattern) detectable on echotracking tracings of the carotid artery (CA) compared to healthy subjects (HS), but we did not study patients with essential hypertension (EH)...
December 2015: Annales de Cardiologie et D'angéiologie
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