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Ekkehard Grünig, Nicola Benjamin, Tobias J Lange, Ulrich Krueger, Hans Klose, Claus Neurohr, Heinrike Wilkens, Michael Halank, Hans-Jürgen Seyfarth, Matthias Held, Andrew Traube, Michelle Pernow, E Robert Grover, Benjamin Egenlauf, Felix Gerhardt, Thomas Viethen, Stephan Rosenkranz
BACKGROUND: Subcutaneous treprostinil has dose-dependent beneficial effects in patients with severe pulmonary arterial hypertension, but adverse effects like infusion site pain can lead to treatment discontinuation. OBJECTIVES: The objective of this study was to evaluate safety, tolerability and clinical effects of a rapid up-titration dosing regimen of subcutaneous treprostinil using proactive infusion site pain management. METHODS: Effects of rapid up-titration dosing regimen on tolerability and clinical parameters were evaluated in this 16-week, open-label multi-centre study...
October 27, 2016: Respiration; International Review of Thoracic Diseases
(no author information available yet)
Background Long-term treatment with supplemental oxygen has unknown efficacy in patients with stable chronic obstructive pulmonary disease (COPD) and resting or exercise-induced moderate desaturation. Methods We originally designed the trial to test whether long-term treatment with supplemental oxygen would result in a longer time to death than no use of supplemental oxygen among patients who had stable COPD with moderate resting desaturation (oxyhemoglobin saturation as measured by pulse oximetry [Spo2], 89 to 93%)...
October 27, 2016: New England Journal of Medicine
C D C Neves, A C R Lacerda, V K S Lage, L P Lima, R Tossige-Gomes, S F Fonseca, E Rocha-Vieira, M M Teixeira, V A Mendonça
Chronic exposure to cigarette smoke seems to be related to an increase of pro-inflammatory cytokines, oxidative stress and changes in muscular and physical performances of healthy smokers. However, these parameters have not yet been evaluated simultaneously in previous studies. The participants of this study were healthy males divided into two groups: smokers (n=20) and non-smokers (n=20). Inflammation was evaluated by measuring plasma levels of the cytokines IL-10, IL-6 e TNF-α, and of the soluble receptors sTNFR1 and sTNFR2...
October 24, 2016: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
Gabriel de Souza Prim, Francisco Assis Souza Santos, Milton Vieira, Victor Nassar
Individuals with transtibial amputations have difficulties in performing march and stay in balance, directly affecting their quality of life. The use of prostheses can enable the rehabilitation of the individual, but we question how effective are for certain tasks and how they can still improve. To evaluate the prosthesis for transtibial amputation, a comparative study was conducted with two groups: Amputee and NOT Amputees. With the help of Motion Capture technology was held measuring the angles of static balance, walking speed and scores in the execution of daily activities...
October 2016: Ciência & Saúde Coletiva
Tania Gallart-Aragón, Carolina Fernández-Lao, Eduardo Castro-Martín, Irene Cantarero-Villanueva, Antonio Cózar-Ibáñez, Manuel Arroyo-Morales
OBJECTIVE: Laparoscopic sleeve gastrectomy (LSG) has demonstrated high long-term effectiveness and major advantages over other techniques. The objective of this study was to analyze changes in physical fitness parameters in morbidly obese patients during 6 months after LSG. METHODOLOGY: We conducted a descriptive observational study with 6-month follow-up in 72 LSG patients, evaluating changes in body mass index (BMI), functional capacity (6-min walking test), hand grip strength (manual dynamometry), flexibility (fingertip-to-floor test), balance (Flamingo test), physical activity level (International Physical Activity Questionnaire, IPAQ), and perception of general physical fitness (International Fitness Scale [IFIS] questionnaire)...
October 25, 2016: Obesity Surgery
Lisa Schuster, Krzysztof Kubacki, Sharyn Rundle-Thiele
Increases in childhood obesity have coincided with declines in active transportation to school. This research builds on largely atheoretical extant literature examining factors that influence walk-to-school behavior through application of the theory of planned behavior (TPB). Understanding caregivers' decision for their child to walk to/from school is key to developing interventions to promote this cost-effective and accessible health behavior. The results from an online survey of 512 caregivers provide support for the TPB, highlighting the important role of subjective norms...
October 26, 2016: Health Marketing Quarterly
Michael Melin, Andreas Montelius, Lars Rydén, Adrian Gonon, Inger Hagerman, Eric Rullman
Enhanced external counterpulsation (EECP) is a non-invasive treatment in which leg cuff compressions increase diastolic aortic pressure and coronary perfusion. EECP is offered to patients with refractory angina pectoris and increases physical capacity. Benefits in heart failure patients have been noted, but EECP is still considered to be experimental and its effects must be confirmed. The mechanism of action is still unclear. The aim of this study was to evaluate the effect of EECP on skeletal muscle gene expression and physical performance in patients with severe heart failure...
October 26, 2016: Clinical Physiology and Functional Imaging
Winfried Ilg, Zofia Fleszar, Cornelia Schatton, Holger Hengel, Florian Harmuth, Peter Bauer, Dagmar Timmann, Martin Giese, Ludger Schöls, Matthis Synofzik
BACKGROUND: Movement changes in autosomal-dominant spinocerebellar ataxias are suggested to occur many years before clinical manifestation. Detecting and quantifying these changes in the preclinical phase offers a window for future treatment interventions and allows the clinician to decipher the earliest dysfunctions starting the evolution of spinocerebellar ataxia. We hypothesized that quantitative movement analysis of complex stance and gait tasks allows to (i) reveal movement changes already at early stages of the preclinical phase when clinical ataxia signs are still absent and to (ii) quantify motor progression in this phase...
October 26, 2016: Movement Disorders: Official Journal of the Movement Disorder Society
Eunjeong Park, Sunghoon I Lee, Hyo Suk Nam, Jordan H Garst, Alex Huang, Andrew Campion, Monica Arnell, Nima Ghalehsariand, Sangsoo Park, Hyuk-Jae Chang, Daniel C Lu, Majid Sarrafzadeh
BACKGROUND: Alcohol ingestion influences sensory-motor function and the overall well-being of individuals. Detecting alcohol-induced impairments in gait in daily life necessitates a continuous and unobtrusive gait monitoring system. OBJECTIVES: This paper introduces the development and use of a non-intrusive monitoring system to detect changes in gait induced by alcohol intoxication. METHODS: The proposed system employed a pair of sensorized smart shoes that are equipped with pressure sensors on the insole...
October 26, 2016: Methods of Information in Medicine
Kellie Toohey, Kate L Pumpa, Leonard Arnolda, Julie Cooke, Desmond Yip, Paul S Craft, Stuart Semple
PURPOSE: The aim of this study was to evaluate the effects of low-volume high-intensity interval training and continuous low to moderate intensity training on quality of life, functional capacity and cardiovascular disease risk factors in cancer survivors. METHODS: Cancer survivors within 24 months post-diagnosis were randomly assigned into the low-volume high-intensity interval training group (n = 8) or the continuous low to moderate intensity training group (n = 8) group for 36 sessions (12 weeks) of supervised exercise...
2016: PeerJ
Ukachukwu Okoroafor Abaraogu, Wisdom Onyedikachi Ugwa, Osita Nnodim, Elochukwu Fortune Ezenwankwo
BACKGROUND: The effects of backpack load on young adults' gait parameters have received little attention. This author group previously reported that with a backpack load within 15% body weight, young adults maintain their gait parameters at the expense of increased exertion during a 6-minute walk at self-selected normal walking speed. However, the effect of backpack strap pattern on gait parameters during faster walking or longer stride length has not been evaluated. OBJECTIVE: To determine the effect of different backpack strap patterns on gait parameters during 12 minute duration walk test in young adults at self-selected normal and fast walking speeds...
October 22, 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
A Godfrey, R Morris, A Hickey, S Del Din
Free-living ambulation with accelerometer-based devices is an attractive methodology to assess habitual behaviour within Parkinson's disease (PD). However, slowness of movement can contribute to difficulty in quantifying ambulatory/walking outcomes within this group by these devices. This study investigates the use of a commercial accelerometer device (activPAL(™)) in those with moderate PD to understand its proprietary software (inbuilt algorithm) limitations. The values provided by the proprietary software are evaluated in comparison to novel algorithms on the same raw data to examine limitations for use within this cohort...
October 22, 2016: Medical Engineering & Physics
Gregory Reychler, Justine Fabre, Amandine Lux, Gilles Caty, Thierry Pieters, Giuseppe Liistro
PURPOSE: The aim of this study was to evaluate the effect of different kinds of music on submaximal performance and exercise tolerance in healthy children by means of the 6-minute walking test (6MWT) and to explore the influence of gender. DESIGN: Cross-over study. METHOD: Ninety-seven children performed 6MWT in four conditions (without music, with their preferred music, with slow and with fast music). Distance, cardio-respiratory parameters, perceived exertion rate, and amount of dyspnea were measured...
October 25, 2016: Rehabilitation Nursing: the Official Journal of the Association of Rehabilitation Nurses
J Maxwell Donelan
We rely on predictions to rapidly select our walking gaits. New research suggests that the formation of these predictions is driven by the difference between the walk we expect and the walk we get.
October 24, 2016: Current Biology: CB
Julia Campbell, John J M Dwyer, Jason B Coe
Promoting dog walking among dog owners is consistent with One Health, which focuses on the mutual health benefits of the human-animal relationship for people and animals. In this study, we used intervention mapping (a framework to develop programs and resources for health promotion) to develop a clearer understanding of the determinants of dog walking to develop curricular and educational resources for promoting regular dog walking among dog owners. Twenty-six adult dog owners in Ontario participated in a semi-structured interview about dog walking in 2014...
October 25, 2016: Journal of Veterinary Medical Education
Mara A McAdams-DeMarco, Hao Ying, Israel Olorundare, Elizabeth A King, Christine Haugen, Brian Buta, Alden L Gross, Rita Kalyani, Niraj M Desai, Nabil N Dagher, Bonnie E Lonze, Robert A Montgomery, Karen Bandeen-Roche, Jeremy D Walston, Dorry L Segev
BACKGROUND: Frailty increases early hospital readmission and mortality risk among kidney transplant (KT) recipients. While frailty represents a high-risk state for this population, the correlates of frailty, the patterns of the 5 frailty components, and the risk associated with these patterns are unclear. METHODS: 663 KT recipients were enrolled in a cohort study of frailty in transplantation (12/2008-8/2015). Frailty, ADL/IADL disability, CESD depression, education, and HRQOL were measured...
October 25, 2016: Transplantation
Cristina Jácome, Alda Marques
PURPOSE: Pulmonary rehabilitation (PR) is effective in patients with moderate to severe chronic obstructive pulmonary disease (COPD). However, the effects of PR in patients with mild COPD have not yet been established. Thus, this study investigated the short- and long-term effects of PR in patients with mild COPD in comparison with patients with moderate to severe disease. METHODS: A total of 32 patients with mild (group 1) and 29 with moderate to severe (group 2) COPD completed the study...
November 2016: Journal of Cardiopulmonary Rehabilitation and Prevention
Marie Boller
No abstract text is available yet for this article.
November 2016: Academic Medicine: Journal of the Association of American Medical Colleges
Nataša Bizovičar, Zlatko Matjačić, Irena Stanonik, Nika Goljar
Regaining of the patient's ability to walk after stroke is an important goal of rehabilitation programmes. The ultimate goal of gait rehabilitation is to empower patients for overground walking. We have previously developed a prototype of a therapist-controlled mobile platform with compliant pelvis support mechanism that enables balance training during overground walking (device E-go). The aim of this pilot randomized controlled study was to explore the usefulness of the E-go in reducing the number of therapists needed during walking training, and to explore the effectiveness of the E-go on walking abilities in severely affected stroke patients...
October 24, 2016: International Journal of Rehabilitation Research. Revue Internationale de Recherches de Réadaptation
Aodhán Hickey, Eleanor Gunn, Lisa Alcock, Silvia Del Din, Alan Godfrey, Lynn Rochester, Brook Galna
Biomarkers are required to track disease progression and measure the effectiveness of interventions for people with spinocerebellar ataxia type-6 (SCA6). Gait is a potential biomarker that is sensitive to SCA6 which can be measured using wearable technology, reducing the need for expensive specialist facilities. However, algorithms used to calculate gait using data from wearables have not been validated in SCA6. This study sought to examine the validity of a single wearable for deriving 14 spatio-temporal gait characteristics in SCA6 and control cohorts...
October 25, 2016: Physiological Measurement
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