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https://www.readbyqxmd.com/read/28647597/hypoxic-postconditioning-improves-behavioural-deficits-at-6-weeks-following-hypoxic-ischemic-brain-injury-in-neonatal-rats
#1
Jonathan D Teo, Margaret J Morris, Nicole M Jones
Hypoxic-ischemic (HI) brain injury in newborns is associated with high morbidity and mortality, with many babies suffering neurological deficits. Recently, we showed that hypoxic postconditioning (PostC) immediately post injury can protect against HI up to one week in neonatal rats. Here, we aimed to examine whether long term functional deficits were also improved by PostC. Sprague-Dawley rats were assigned to control (C) or HI group on postnatal day 7 (P7). The HI group underwent unilateral carotid artery occlusion followed by hypoxia (7% oxygen, 3h)...
June 21, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28647467/reliability-and-measurement-error-of-the-osteoarthritis-research-society-international-recommended-performance-based-tests-of-physical-function-in-people-with-hip-and-knee-osteoarthritis
#2
Fiona Dobson, Rana S Hinman, Michelle Hall, Charlotte J Marshall, Tim Sayer, Clinton Anderson, Nicolas Newcomb, Paul W Stratford, Kim L Bennell
OBJECTIVE: To estimate the reliability and measurement error of performance-based tests of physical function recommended by the Osteoarthritis Research Society International in people with hip and/or knee osteoarthritis. DESIGN: Prospective repeated measures between independent raters within a session and within-rater over a week interval. Relative reliability was estimated for 51 people with hip and/or knee osteoarthritis (mean age 64.5 years, SD 6.21 years; 47% females; 36 (70%) primary knee OA) on the 30s Chair Stand Test (30sCST), 40m Fast Paced Walk Test (40mFPWT), 11-Stair Climb Test (11-step SCT), Timed Up and Go (TUG), Six Minute Walk Test (6MWT), 10m Fast Paced Walk Test (10mFPWT) and 20s Stair Climb Test (20sSCT) using intra-class correlation coefficients (ICC)...
June 21, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28647194/prediction-of-6-minute-walk-performance-in-patients-with-peripheral-artery-disease
#3
Xi Chen, Julie A Stoner, Polly S Montgomery, Ana I Casanegra, Federico Silva-Palacios, Sixia Chen, Amanda E Janitz, Andrew W Gardner
BACKGROUND: Peripheral artery disease (PAD) is a highly prevalent disease that impairs walking ability. Walking tests, such as the 6-minute walk test (6MWT) and 4-meter walk test, are commonly used to assess exercise endurance and ambulatory function over a short distance, respectively. The 6MWT performance is predictive of PAD severity and disease outcomes, but it is not feasible in many clinical settings because it requires a long walkway to serve as the test route and lengthens clinic visits...
June 21, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28647130/fever-induced-paroxysmal-weakness-and-encephalopathy-a-new-phenotype-of-atp1a3-mutation
#4
Sho T Yano, Kenneth Silver, Richard Young, Suzanne D DeBrosse, Roseànne S Ebel, Kathryn J Swoboda, Gyula Acsadi
BACKGROUND: We identified a group of patients with ATP1A3 mutations at residue 756 who display a new phenotype, distinct from alternating hemiplegia of childhood, rapid-onset dystonia-parkinsonism, and cerebellar ataxia, areflexia, pes cavus, optic atrophy, sensorineural hearing loss syndromes. METHODS: Four patients with c.2267G>A (R756H) mutations from two families and two patients with c.2267G>T (R756L) mutations from one family are described and compared with the previously reported patients with mutations resulting in R756H and R756C protein variants...
April 29, 2017: Pediatric Neurology
https://www.readbyqxmd.com/read/28647034/muscle-strength-and-control-characteristics-are-altered-by-peripheral-artery-disease
#5
Molly N Schieber, Ryan M Hasenkamp, Iraklis I Pipinos, Jason M Johanning, Nicholas Stergiou, Holly K DeSpiegelaere, Jung H Chien, Sara A Myers
OBJECTIVE: Peripheral artery disease (PAD), a common manifestation of atherosclerosis, is characterized by lower leg ischemia and myopathy in association with leg dysfunction. Patients with PAD have impaired gait from the first step they take with consistent defects in the movement around the ankle joint, especially in plantar flexion. Our goal was to develop muscle strength profiles to better understand the problems in motor control responsible for the walking impairment in patients with PAD...
July 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28646841/effect-of-extracorporeal-shock-wave-therapy-on-lower-limb-spasticity-in-stroke-patients
#6
Parisa Taheri, Babak Vahdatpour, Maryam Mellat, Fereshteh Ashtari, Mojtaba Akbari
BACKGROUND: This study aims to evaluate the effect of extracorporeal shock wave therapy (ESWT) on lower limb spasticity in stroke patients. METHODS: Twenty-eight eligible patients with ankle plantar flexor spasticity were randomly assigned to two groups. ESWT group received 1 session per week for 3 weeks of ESWT along with oral anti-spastic medications and stretching exercises. The control group received only oral anti-spastic medications and stretching exercises similar to ESWT group...
June 2017: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/28646454/the-oswestry-disability-index-confirmatory-factor-analysis-in-a-sample-of-35-263-verifies-a-one-factor-structure-but-practicality-issues-remain
#7
Charles Philip Gabel, Antonio Cuesta-Vargas, Meihua Qian, Rok Vengust, Ulrich Berlemann, Emin Aghayev, Markus Melloh
PURPOSE: To analyze the factor structure of the Oswestry Disability Index (ODI) in a large symptomatic low back pain (LBP) population using exploratory (EFA) and confirmatory factor analysis (CFA). METHODS: Analysis of pooled baseline ODI LBP patient data from the international Spine Tango registry of EUROSPINE, the Spine Society of Europe. The sample, with n = 35,263 (55.2% female; age 15-99, median 59 years), included 76.1% of patients with a degenerative disease, and 23...
June 23, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28646369/impacts-of-a-temporary-urban-pop-up-park-on-physical-activity-and-other-individual-and-community-level-outcomes
#8
Deborah Salvo, Jorge A Banda, Jylana L Sheats, Sandra J Winter, Daniela Lopes Dos Santos, Abby C King
Physical inactivity is a known risk factor for obesity and a number of chronic diseases. Modifying the physical features of neighborhoods to provide residents with equitable and convenient access to spaces for physical activity (PA) is a promising strategy for promoting PA. Public urban recreation spaces (e.g., parks) play an important role in promoting PA and are potentially an important neighborhood element for optimizing social capital and liveability in cities. Most studies examining the effects of park availability and use on PA have focused on traditional, permanent parks...
June 23, 2017: Journal of Urban Health: Bulletin of the New York Academy of Medicine
https://www.readbyqxmd.com/read/28646245/six-minute-walk-test-as-a-predictor-of-diagnosis-disease-severity-and-clinical-outcomes-in-scleroderma-associated-pulmonary-hypertension-the-dibosa-study
#9
Abhishek Gadre, Christian Ghattas, Xiaozhen Han, Xiaofeng Wang, Omar Minai, Kristin B Highland
BACKGROUND: Pulmonary hypertension (PH) is a common complication of scleroderma (SSc) and is a leading cause of morbidity and mortality. OBJECTIVES: To explore the utility of the 6MWT in the prediction of SSc-PH and to assess its prognostic implications. METHODS: A retrospective review of SSc patients from 2003 to 2013, with 6MWT and echocardiogram (n = 286), was conducted. Presence of PH was defined by right heart catheterization. Patients were randomized into development and validation cohorts...
June 23, 2017: Lung
https://www.readbyqxmd.com/read/28645969/protocol-for-the-residents-in-action-pilot-cluster-randomised-controlled-trial-riat-evaluating-a-behaviour-change-intervention-to-promote-walking-reduce-sitting-and-improve-mental-health-in-physically-inactive-older-adults-in-retirement-villages
#10
Cecilie Thøgersen-Ntoumani, Ashlene Wright, Eleanor Quested, Elissa Burton, Keith D Hill, Ester Cerin, Stuart J H Biddle, Nikos Ntoumanis
INTRODUCTION: Ageing is accompanied by increased risks of chronic disease, declined functioning and increased dependency. Physical activity is critical to retaining health and independence, but the majority of older people are insufficiently physically active to achieve these benefits and have high levels of sedentary (sitting) time. Activity programmes are often offered in retirement villages; however, their uptake is limited. Furthermore, although the physical environment in and around these villages can play an important role in decisions to be physically active, its role is often overlooked by research in these settings...
June 23, 2017: BMJ Open
https://www.readbyqxmd.com/read/28645948/the-relationship-between-bicycle-commuting-and-perceived-stress-a-cross-sectional-study
#11
Ione Avila-Palencia, Audrey de Nazelle, Tom Cole-Hunter, David Donaire-Gonzalez, Michael Jerrett, Daniel A Rodriguez, Mark J Nieuwenhuijsen
INTRODUCTION: Active commuting - walking and bicycling for travel to and/or from work or educational addresses - may facilitate daily, routine physical activity. Several studies have investigated the relationship between active commuting and commuting stress; however, there are no studies examining the relationship between solely bicycle commuting and perceived stress, or studies that account for environmental determinants of bicycle commuting and stress. The current study evaluated the relationship between bicycle commuting, among working or studying adults in a dense urban setting, and perceived stress...
June 23, 2017: BMJ Open
https://www.readbyqxmd.com/read/28645850/biomechanical-analysis-using-fea-and-experiments-of-a-standard-plate-method-versus-three-cable-methods-for-fixing-acetabular-fractures-with-simultaneous-tha
#12
Mina S R Aziz, Omar Dessouki, Saeid Samiezadeh, Habiba Bougherara, Emil H Schemitsch, Radovan Zdero
Acetabular fractures potentially account for up to half of all pelvic fractures, while pelvic fractures potentially account for over one-tenth of all human bone fractures. This is the first biomechanical study to assess acetabular fracture fixation using plates versus cables in the presence of a total hip arthroplasty, as done for the elderly. In Phase 1, finite element (FE) models compared a standard plate method versus 3 cable methods for repairing an acetabular fracture (type: anterior column plus posterior hemi-transverse) subjected to a physiological-type compressive load of 2207N representing 3 x body weight for a 75kg person during walking...
June 20, 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/28645768/robot-assisted-training-for-people-with-spinal-cord-injury-a-meta-analysis
#13
REVIEW
Eddy Yy Cheung, Thomas Kw Ng, Kevin Kk Yu, Rachel Lc Kwan, Gladys Ly Cheing
OBJECTIVE: To investigate the effects of robotic-assisted training on the recovery of people with spinal cord injury (SCI). DATA SOURCE: Randomized controlled trials (RCTs) or quasi-RCTs involving people with SCI that compared robotic-assisted upper limbs or lower limbs training to a control of other treatment approach or no treatment. We included studies involving people with complete or incomplete spinal cord injuries. STUDY SELECTION: We searched in Medline, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Cochrane Central Register of Controlled Trials (Cochrane Library) and Excerpta Medica dataBASE (EMBASE) to August, 2016...
June 20, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28645757/sympathetic-response-and-outcomes-following-renal-denervation-in-patients-with-chronic-heart-failure-12-month-outcomes-from-the-symplicity-hf-feasibility-study
#14
Ingrid Hopper, Edoardo Gronda, Uta C Hoppe, Bengt Rundqvist, Thomas H Marwick, Sharad Shetty, Christopher Hayward, Thomas Lambert, Dagmara Hering, Murray Esler, Markus Schlaich, Antony Walton, Flavio Airoldi, Mathias-Christoph Brandt, Sidney A Cohen, Pascalle Reiters, Henry Krum
BACKGROUND: Heart failure (HF) is associated with chronic sympathetic activation. Renal denervation (RDN) aims to reduce sympathetic activity by ablating the renal sympathetic nerves. We investigated the effect of RDN in patients with chronic HF and concurrent renal dysfunction, in a prospective, multicenter, single-arm feasibility study. METHODS AND RESULTS: Thirty-nine patients with chronic systolic HF (left ventricular ejection fraction [LVEF] <40%, New York Heart Association class II-III,) and renal impairment (estimated glomerular filtration rate [eGFR; assessed with Modification of Diet in Renal Disease equation] <75 mL/min/1...
June 20, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28645496/determining-the-best-percent-predicted-equation-for-estimated-vo2-peak-by-a-1-km-moderate-perceptually-regulated-treadmill-walk-to-predict-mortality-in-outpatients-with-cardiovascular-disease
#15
Giovanni Grazzi, Gianni Mazzoni, Jonathan Myers, Luciano Codecà, Giovanni Pasanisi, Simona Mandini, Massimo Piepoli, Stefano Volpato, Francesco Conconi, Giorgio Chiaranda
OBJECTIVES: To determine the prognostic ability of established percent-predicted equations of peak oxygen consumption (%PRED) estimated by a moderate submaximal walking test in a large cohort of outpatients with cardiovascular disease (CVD). DESIGN: Population-based prospective study. METHODS: A total of 1442 male patients aged 25-85 years at baseline, underwent a moderate perceptually-regulated (11-13 on the 6-20 Borg scale) treadmill walk (1k-TWT) for peak oxygen consumption estimation (VO2 peak)...
June 8, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28645458/pulmonary-3-he-magnetic-resonance-imaging-biomarkers-of-regional-airspace-enlargement-in-alpha-1-antitrypsin-deficiency
#16
Eric Lessard, Heather M Young, Anurag Bhalla, Damien Pike, Khadija Sheikh, David G McCormack, Alexei Ouriadov, Grace Parraga
RATIONALE AND OBJECTIVES: Thoracic x-ray computed tomography (CT) and hyperpolarized (3)He magnetic resonance imaging (MRI) provide quantitative measurements of airspace enlargement in patients with emphysema. For patients with panlobular emphysema due to alpha-1 antitrypsin deficiency (AATD), sensitive biomarkers of disease progression and response to therapy have been difficult to develop and exploit, especially those biomarkers that correlate with outcomes like quality of life. Here, our objective was to generate and compare CT and diffusion-weighted inhaled-gas MRI measurements of emphysema including apparent diffusion coefficient (ADC) and MRI-derived mean linear intercept (Lm) in patients with AATD, chronic obstructive pulmonary disease (COPD) ex-smokers, and elderly never-smokers...
June 20, 2017: Academic Radiology
https://www.readbyqxmd.com/read/28645253/a-case-report-of-thoracolumbar-paraspinal-myopathy-as-the-cause-of-camptocormia-in-a-patient-with-atypical-parkinsonism
#17
Yoon Kim, Ahro Kim, Aryun Kim, Beomseok Jeon
BACKGROUND: Camptocormia is severe flexion of the thoracolumbar spine, exaggerated during standing and walking but minimized in supine position. Even though camptocormia is a relatively common condition during the course of Parkinson's disease, there is ongoing controversy concerning its mechanisms. The most widely accepted and yet still disputed one is dystonia. However, based on myopathic changes observed in the paraspinal muscle biopsies of some PD patients with camptocormia, the attempt to attribute camptocormia to myopathy has continued...
June 23, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28645036/influence-of-surface-states-on-blinking-characteristics-of-single-colloidal-cdse-cds-zns-core-multishell-quantum-dot
#18
Hao Xu, Hjalmar Brismar, Ying Fu
We carefully characterized the fluorescence blinking of single colloidal CdSe-CdS/ZnS core-multishell quantum dots (QDs) with different surface modifications, including octadecylamine (ODA) coated QDs dispersed in chloroform, aqueous 3-mercaptopropionic acids (3MPA) coated QDs in HEPES solution treated by Ca(2+) ions and ethylene glycol tetraacetic acid (EGTA, Ca(2+) chelator), and aqueous 3MPA-QDs treated by glycerol. It was found that the on- and off-state probability density distributions displayed different rules...
June 16, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28644923/examining-transfer-effects-of-dual-task-training-protocols-for-a-complex-locomotor-task
#19
Timothy A Worden, Lori Ann Vallis
Training protocols designed to improve dual-task performance of an obstacle crossing and auditory Stroop task (OBS+Stroop) were tested. In Experiment  1 , following baseline collection of OBS+Stroop trials, proximally related walking training was performed, and participants were then retested on the OBS+Stroop test. After training, participants adopted a more cautious obstacle crossing strategy, indicating a potentially safer navigation strategy. Transfer effects from distally related training were then examined (Experiment  2 ); a computer game training paradigm was examined using the same testing protocol as Experiment  1 ...
June 23, 2017: Journal of Motor Behavior
https://www.readbyqxmd.com/read/28644833/quantifying-the-web-browser-ecosystem
#20
Sela Ferdman, Einat Minkov, Ron Bekkerman, David Gefen
Contrary to the assumption that web browsers are designed to support the user, an examination of a 900,000 distinct PCs shows that web browsers comprise a complex ecosystem with millions of addons collaborating and competing with each other. It is possible for addons to "sneak in" through third party installations or to get "kicked out" by their competitors without user involvement. This study examines that ecosystem quantitatively by constructing a large-scale graph with nodes corresponding to users, addons, and words (terms) that describe addon functionality...
2017: PloS One
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